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BMRN Biomarin Pharmaceutical Inc. - Registered Shares

BioMarin Pharmaceutical, Inc. is a biotechnology company, which engages in the development and commercialization of therapies for people with serious and life-threatening rare diseases and medical conditions. Its pipeline include Vosoritide (BMN 111) for Achondroplasia and Valoctocogene Roxaparvovec (BMN 270) for Hemophilia A. The company was founded by John C. Klock, Christopher M. Starr and Grant W. Denison on March 21, 1997 and is headquartered in San Rafael, CA.

Company profile

Ticker
BMRN
Exchange
Website
CEO
Jean-Jacques Bienaime
Employees
Incorporated
Location
Fiscal year end
SEC CIK
IRS number
680397820

BMRN stock data

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Press releases

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Calendar

26 Feb 21
13 Apr 21
31 Dec 21
Quarter (USD)
Dec 20 Sep 20 Jun 20 Mar 20
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Annual (USD)
Dec 20 Dec 19 Dec 18 Dec 17
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS

Financial data from company earnings reports.

Cash burn rate (estimated) Burn method: Change in cash Burn method: Operating income/loss Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 649.16M 649.16M 649.16M 649.16M 649.16M 649.16M
Cash burn (monthly) 122.17M (positive/no burn) 14.95M 3.61M 4.46M (positive/no burn)
Cash used (since last report) 422.38M n/a 51.67M 12.49M 15.42M n/a
Cash remaining 226.77M n/a 597.48M 636.66M 633.73M n/a
Runway (months of cash) 1.9 n/a 40.0 176.2 142.1 n/a

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
8 Apr 21 Jeffrey Robert Ajer Common Stock Sell Dispose S No Yes 78.81 1,537 121.13K 58,250
1 Apr 21 Mueller Brian Common Stock Sell Dispose S No Yes 76.3 5,692 434.3K 31,016
30 Mar 21 Jeffrey Robert Ajer Common Stock Sell Dispose S No Yes 74.79 1,652 123.55K 59,787
24 Mar 21 Jeffrey Robert Ajer Common Stock Sell Dispose S No Yes 76.3 1,181 90.11K 61,439
22 Mar 21 Jeffrey Robert Ajer Common Stock Payment of exercise Dispose F No No 78.52 1,513 118.8K 62,620

Data for the last complete 13F reporting period. To see the most recent changes to ownership, click the ownership history button above.

99.9% owned by funds/institutions
13F holders
Current Prev Q Change
Total holders 521 484 +7.6%
Opened positions 93 62 +50.0%
Closed positions 56 94 -40.4%
Increased positions 186 182 +2.2%
Reduced positions 168 178 -5.6%
13F shares
Current Prev Q Change
Total value 21.2B 13.43B +57.8%
Total shares 181.58M 176.59M +2.8%
Total puts 2.45M 1.71M +43.8%
Total calls 3.14M 1.88M +67.3%
Total put/call ratio 0.8 0.9 -14.0%
Largest owners
Shares Value Change
Capital Research Global Investors 22.08M $1.94B +0.1%
Primecap Management 18.15M $1.59B -0.2%
Vanguard 16.37M $1.44B +0.2%
BLK Blackrock 14.71M $1.29B +0.5%
Dodge & Cox 9.8M $859.09M +26.9%
Baker Bros. Advisors 7.59M $665.51M 0.0%
Clearbridge Advisors 6.02M $528.11M -2.4%
JHG Janus Henderson 5.69M $498.68M +9.1%
STT State Street 4.96M $434.92M +1.4%
AMP Ameriprise Financial 4.36M $382.2M +45.0%
Largest transactions
Shares Bought/sold Change
Dodge & Cox 9.8M +2.08M +26.9%
Norges Bank 1.45M +1.45M NEW
AMP Ameriprise Financial 4.36M +1.35M +45.0%
Parnassus Investments 1.52M +1.33M +712.0%
Avidity Partners Management 992.9K +992.9K NEW
Carillon Tower Advisers 1.09M +814.74K +295.6%
Natixis 1.42M +799.21K +128.3%
JPM JPMorgan Chase & Co. 2.48M -737.79K -22.9%
FMR 79.59K -588.55K -88.1%
Marshall Wace North America 404.69K -588.17K -59.2%

Financial report summary

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Risks
  • The COVID-19 pandemic could materially adversely affect our business, results of operations, and financial condition.
  • Because the target patient populations for our products are small, we must achieve significant market share and maintain high per-patient prices for our products to achieve profitability.
  • If we fail to obtain and maintain an adequate level of coverage and reimbursement for our products by third-party payers, the sales of our products would be adversely affected or there may be no commercially viable markets for our products.
  • If we fail to compete successfully with respect to product sales, we may be unable to generate sufficient sales to recover our expenses related to the development of a product program or to justify continued marketing of a product and our revenue could be adversely affected.
  • Changes in methods of treatment of disease could reduce demand for our products and adversely affect revenues.
  • If we fail to develop new products and product candidates or compete successfully with respect to acquisitions, joint ventures, licenses or other collaboration opportunities, our ability to continue to expand our product pipeline and our growth and development would be impaired.
  • The sale of generic versions of Kuvan by generic manufacturers has adversely affected and may continue to adversely affect our revenue and results of operations.
  • If we do not achieve our projected development goals in the timeframes we announce and expect, the commercialization of our product candidates may be delayed and the credibility of our management may be adversely affected and, as a result, our stock price may decline.
  • If we fail to obtain regulatory approval to commercially market and sell our product candidates, or if approval of our product candidates is delayed, we will be unable to generate revenue from the sale of these product candidates, our potential for generating positive cash flow will be diminished, and the capital necessary to fund our operations will increase.
  • Any product for which we have obtained regulatory approval, or for which we obtain approval in the future, is subject to, or will be subject to, extensive ongoing regulatory requirements by the FDA, the EMA and other comparable international regulatory authorities, and if we fail to comply with regulatory requirements or if we experience unanticipated problems with our products, we may be subject to penalties, we will be unable to generate revenue from the sale of such products, our potential for generating positive cash flow will be diminished, and the capital necessary to fund our operations will be increased.
  • To obtain regulatory approval to market our products, preclinical studies and costly and lengthy clinical trials are required and the results of the studies and trials are highly uncertain. Likewise, preliminary, initial or interim data from clinical trials should be considered carefully and with caution because the final data may be materially different from the preliminary, initial or interim data, particularly as more patient data become available.
  • Government price controls or other changes in pricing regulation could restrict the amount that we are able to charge for our current and future products, which would adversely affect our revenue and results of operations.
  • Government healthcare reform could increase our costs and adversely affect our revenue and results of operations.
  • If we fail to obtain or maintain orphan drug exclusivity for some of our products, our competitors may obtain approval to sell the same drugs to treat the same conditions and our revenues will be reduced.
  • We may face competition from biosimilars approved through an abbreviated regulatory pathway.
  • Changes in funding for the FDA, the EMA and other government agencies or government shutdowns could hinder the ability of such agencies to hire and retain key leadership and other personnel or otherwise prevent those agencies from performing normal functions on which the operation of our business may rely, which could negatively impact our business.
  • Our valoctocogene roxaparvovec program is based on a gene therapy approach, which, as a novel technology, presents additional development and treatment risks in relation to our other, more traditional drug development programs.
  • As compared to our other, more traditional products, our gene therapy product candidate valoctocogene roxaparvovec, if approved, may present additional problems with respect to the pricing, coverage, and reimbursement and acceptance of the product candidate.
  • We have implemented a data access plan for valoctocogene roxaparvovec, which restricts our management’s review of emerging data from these trials. Without access to ongoing data, management does not have the ability to adjust the trials based on such emerging data, which could adversely impact the ultimate outcome of these trials.
  • If we continue to incur operating losses or are unable to sustain positive cash flows for a period longer than anticipated, we may be unable to continue our operations at planned levels and be forced to reduce our operations.
  • If we fail to obtain the capital necessary to fund our operations, our financial results and financial condition will be adversely affected and we will have to delay or terminate some or all of our product development programs.
  • We have incurred substantial indebtedness that may decrease our business flexibility, access to capital, and/or increase our borrowing costs, which may adversely affect our operations and financial results.
  • In addition, our ability to refinance our indebtedness will depend on the capital markets and our financial condition at such time.
  • If we fail to comply with manufacturing regulations, our financial results and financial condition will be adversely affected.
  • If we are unable to successfully develop and maintain manufacturing processes for our product candidates to produce sufficient quantities at acceptable costs, we may be unable to support a clinical trial or be forced to terminate a program, or if we are unable to produce sufficient quantities of our products at acceptable costs, we may be unable to meet commercial demand, lose potential revenue, have reduced margins or be forced to terminate a program.
  • Supply interruptions may disrupt our inventory levels and the availability of our products and product candidates and cause delays in obtaining regulatory approval for our product candidates, or harm our business by reducing our revenues.
  • If our Manufacturing, Marketing and Sales Agreement with Genzyme were terminated, we could be prevented from continuing to commercialize Aldurazyme or our ability to successfully commercialize Aldurazyme would be delayed or diminished.
  • We conduct a significant amount of our sales and operations outside of the U.S., which subjects us to additional business risks that could adversely affect our revenue and results of operations.
  • A significant portion of our international sales are made based on special access programs, and changes to these programs could adversely affect our product sales and revenue in these countries.
  • U.S. export control and economic sanctions may adversely affect our business, financial condition and operating results. Moreover, compliance with such regulatory requirements may increase our costs and negatively impact our ability to sell our products and collect cash from customers.
  • Failure to comply with applicable anti-corruption legislation could result in fines, criminal penalties and materially adversely affect our business, financial condition and results of operations.
  • Our international operations pose currency risks, which may adversely affect our operating results and net income.
  • We face credit risks from government-owned or sponsored customers outside of the U.S. that may adversely affect our results of operations.
  • If we are unable to protect our intellectual property, we may not be able to compete effectively or preserve our market shares.
  • Competitors and other third parties may have developed intellectual property that could limit our ability to market and commercialize our products and product candidates, if approved.
  • Our stock price may be volatile, and an investment in our stock could suffer a decline in value.
  • Conversion of the Notes will dilute the ownership interest of existing stockholders, including holders who had previously converted their Notes, or may otherwise depress the price of our common stock.
  • Anti-takeover provisions in our charter documents and under Delaware law may make an acquisition of us, which may be beneficial to our stockholders, more difficult.
  • The fundamental change repurchase feature of the Notes may delay or prevent an otherwise beneficial attempt to take us over.
  • Our amended and restated bylaws designate the Court of Chancery of the State of Delaware and the federal district courts of the U.S. as the exclusive forums for the adjudication of certain disputes, which could limit our stockholders’ ability to obtain a favorable judicial forum for disputes with us or our directors, officers, or employees.
  • We depend upon our key personnel and our ability to attract and retain employees.
  • Our success depends on our ability to manage our growth.
  • Changes in tax laws or regulations that are applied adversely to us or our customers may have a material adverse effect on our business and financial condition.
  • If we are found in violation of healthcare laws or privacy and data protection laws, we may be required to pay penalties, be subjected to scrutiny by regulators or governmental entities, or be suspended from participation in government healthcare programs, which may adversely affect our business, financial condition and results of operations.
  • If product liability lawsuits are successfully brought against us, we may incur substantial liabilities.
  • We rely significantly on information technology systems and any failure, inadequacy, interruption or security lapse of that technology, including any cybersecurity incidents, could harm our ability to operate our business effectively and have a material adverse effect on our business, reputation, financial condition, and results of operations.
  • If a natural disaster, terrorist or criminal activity or other unforeseen event caused significant damage to our facilities or those of our third-party manufacturers and suppliers or significantly disrupted our operations or those of our third-party manufacturers and suppliers, we may be unable to meet demand for our products and lose potential revenue, have reduced margins, or be forced to terminate a program.
  • Our business is affected by macroeconomic conditions.
Management Discussion
  • Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations
  • We are a global biotechnology company that develops and commercializes innovative therapies for people with serious and life-threatening rare diseases and medical conditions. We select product candidates for diseases and conditions that represent a significant unmet medical need, have well-understood biology and provide an opportunity to be first-to-market or offer a significant benefit over existing products.
  • Our portfolio consists of several commercial products and multiple clinical and preclinical product candidates for the treatment of various diseases. A summary of our commercial products, as of December 31, 2020, is provided below:
Content analysis
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Positive
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H.S. sophomore Avg
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Patents

APP
Utility
Lysosomal Targeting Peptides and Uses Thereof
11 Mar 21
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology.
GRANT
Utility
Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
2 Mar 21
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
GRANT
Utility
Glucosylceramide synthase inhibitors for the treatment of diseases
23 Feb 21
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
APP
Utility
Methods of Diagnosing a Disease and Methods of Monitoring Treatment of a Disease by Quantifying a Non-reducing End Glycan Residual Compound and Comparing to a Second Biomarker
28 Jan 21
Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
APP
Utility
Detection of Oligosaccharides
21 Jan 21
Provided herein are processes for detecting oligosaccharides in a biological sample.