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Ocular Therapeutix (OCUL)

Ocular Therapeutix, Inc. is a biopharmaceutical company focused on the formulation, development, and commercialization of innovative therapies for diseases and conditions of the eye using its proprietary bioresorbable hydrogel-based formulation technology. Ocular Therapeutix's first commercial drug product, DEXTENZA (dexamethasone ophthalmic insert) 0.4 mg for intracanalicular use, is FDA-approved for the treatment of ocular inflammation and pain following ophthalmic surgery. Ocular Therapeutix has also submitted a Supplemental NDA for DEXTENZA to include the treatment of ocular itching associated with allergic conjunctivitis as an additional approved indication. Ocular Therapeutix's earlier stage development assets currently in Phase 1 clinical trials include OTX-TKI (axitinib intravitreal implant) for the treatment of wet AMD and other retinal diseases and OTX-TIC (travoprost intracameral implant) for the reduction of intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. Ocular Therapeutix is currently evaluating each of OTX-CSI (cyclosporine intracanalicular insert) for the chronic treatment of dry eye disease and OTX-DED (dexamethasone intracanalicular insert) for the short-term treatment of the signs and symptoms of dry eye disease in Phase 2 clinical trials. Also, in collaboration with Regeneron, OTX-AFS (aflibercept suprachoroidal injection) is in pre-clinical development as an extended-delivery formulation of aflibercept for the treatment of retinal diseases. Ocular Therapeutix's first product, ReSure® Sealant is an FDA-approved device to prevent wound leaks in corneal incisions following cataract surgery.

Company profile

Ticker
OCUL
Exchange
Website
CEO
Antony Mattessich
Employees
Incorporated
Location
Fiscal year end
Former names
I-THERAPEUTIX INC
SEC CIK
Subsidiaries
Ocular Therapeutix Europe B.V. • Ocular Therapeutix Securities Corp. ...

OCUL stock data

Analyst ratings and price targets

Last 3 months

Investment data

Data from SEC filings
Securities sold
Number of investors

Calendar

9 May 22
26 Jun 22
31 Dec 22
Quarter (USD) Mar 22 Dec 21 Sep 21 Jun 21
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Annual (USD) Dec 21 Dec 20 Dec 19 Dec 18
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Cash burn rate (est.) Burn method: Change in cash Burn method: Operating income Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 147.18M 147.18M 147.18M 147.18M 147.18M 147.18M
Cash burn (monthly) 6.25M 5.33M 5.94M 6.3M 6.2M 5.57M
Cash used (since last report) 17.93M 15.29M 17.06M 18.09M 17.79M 15.97M
Cash remaining 129.25M 131.89M 130.12M 129.09M 129.39M 131.21M
Runway (months of cash) 20.7 24.7 21.9 20.5 20.9 23.6

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
16 Jun 22 Hong Seung Suh Common Stock Grant Acquire A No No 0 8,933 0 8,933
16 Jun 22 Hong Seung Suh Stock Option Common Stock Grant Acquire A No No 3.43 26,800 91.92K 26,800
16 Jun 22 Heier Jeffrey S. Common Stock Grant Acquire A No No 0 8,933 0 47,933
16 Jun 22 Heier Jeffrey S. Stock Option Common Stock Grant Acquire A No No 3.43 26,800 91.92K 26,800
16 Jun 22 Lindstrom Richard L MD Common Stock Grant Acquire A No No 0 8,933 0 108,402
16 Jun 22 Lindstrom Richard L MD Stock Option Common Stock Grant Acquire A No No 3.43 26,800 91.92K 26,800
16 Jun 22 Warden Charles M Common Stock Grant Acquire A No No 0 8,933 0 48,464
16 Jun 22 Warden Charles M Stock Option Common Stock Grant Acquire A No No 3.43 26,800 91.92K 26,800
16 Jun 22 Williams Leslie J. Common Stock Grant Acquire A No No 0 8,933 0 13,433
16 Jun 22 Williams Leslie J. Stock Option Common Stock Grant Acquire A No No 3.43 26,800 91.92K 26,800
56.9% owned by funds/institutions
13F holders Current Prev Q Change
Total holders 128 139 -7.9%
Opened positions 14 27 -48.1%
Closed positions 25 28 -10.7%
Increased positions 44 51 -13.7%
Reduced positions 42 42
13F shares Current Prev Q Change
Total value 240.84M 1.57B -84.7%
Total shares 43.64M 41.43M +5.3%
Total puts 167.4K 279.4K -40.1%
Total calls 153.4K 306.7K -50.0%
Total put/call ratio 1.1 0.9 +19.8%
Largest owners Shares Value Change
Opaleye Management 5.97M $29.58M 0.0%
Summer Road 5.94M $29.43M +3.1%
BLK Blackrock 5.07M $25.09M -1.0%
Vanguard 4.2M $20.77M +2.9%
Deltec Asset Management 2.08M $10.28M -0.9%
STT State Street 1.7M $8.44M -1.5%
Citadel Advisors 1.69M $8.38M +10.5%
Geode Capital Management 1.36M $6.75M +3.5%
Emerald Advisers 1.29M $6.4M +22.1%
Emerald Mutual Fund Advisers Trust 1.09M $5.41M +9.6%
Largest transactions Shares Bought/sold Change
FHI Federated Hermes 622.28K +622.28K NEW
Millennium Management 735.73K +443.54K +151.8%
Renaissance Technologies 510.81K +430.71K +537.7%
Los Angeles Capital Management & Equity Research 350.29K +350.29K NEW
Ubs Oconnor 300K +300K NEW
Emerald Advisers 1.29M +234.18K +22.1%
BMO Bank of Montreal 210.94K +210.94K NEW
Endurant Capital Management 923.96K +206.82K +28.8%
MS Morgan Stanley 221.66K -200.71K -47.5%
Summer Road 5.94M +180K +3.1%

Financial report summary

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Management Discussion
  • We are a biopharmaceutical company focused on the formulation, development, and commercialization of innovative therapies for diseases and conditions of the eye using our proprietary bioresorbable hydrogel-based formulation technology. Core to our strategy is (i) to continue to build upon our experience commercializing ophthalmology products that can be administered primarily in the surgical and/or office settings and (ii) to continue to develop a clinical pipeline of innovative ophthalmology products that address large areas of unmet need.
  • We currently have two FDA-approved products in commercialization in the United States: DEXTENZA, an intracanalicular insert for the treatment of both post-surgical ocular inflammation and pain and ocular itching associated with allergic conjunctivitis, and ReSure Sealant, an ophthalmic device designed to prevent wound leaks in corneal incisions following cataract surgery. We also have product candidates in preclinical and clinical development designed to utilize our proprietary, bioresorbable hydrogel technology to treat retinal diseases including wet age-related macular degeneration, or wet AMD; glaucoma and ocular hypertension; and ocular surface diseases and conditions including dry eye disease.
  • We incorporate therapeutic agents that have previously received regulatory approval from the U.S. Food and Drug Administration, or FDA, including small molecules and proteins, into our proprietary bioresorbable hydrogel-based formulation technology in our internal drug development activities, with the goal of providing local programmed release to tailor the duration and amount of drug to be delivered to the eye. We believe that our local programmed-release drug delivery technology has the potential to treat conditions and diseases of both the front and the back of the eye and can be administered through a range of different modalities including intravitreal implants, suprachoroidal implants, intracameral implants and intracanalicular inserts.

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Patents

Utility
Ocular Insert Containing a Glucocorticoid
16 Jun 22
In certain embodiments, the invention relates to a sustained release biodegradable intracanalicular insert containing a glucocorticoid dispersed in a hydrogel for the treatment of dry eye disease.
Utility
Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
17 May 22
Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Utility
Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
5 Apr 22
Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Utility
Sustained Release Biodegradable Intracanalicular Inserts Comprising a Hydrogel and Cyclosporine
24 Mar 22
Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Utility
Sustained Release Biodegradable Intracanalicular Inserts Comprising a Hydrogel and Cyclosporine
24 Mar 22
Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.