Denali Therapeutics is a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases. Denali pursues new treatments by rigorously assessing genetically validated targets, engineering delivery across the BBB and guiding development through biomarkers that demonstrate target and pathway engagement. Denali is based in South San Francisco.

Company profile
Ticker
DNLI
Exchange
Website
CEO
Ryan Watts
Employees
Incorporated
Location
Fiscal year end
Industry (SIC)
AMGEN • Gilead Sciences • Biogen • Qiagen • Moderna • BioNTech SE • Sana Biotechnology • Ginkgo Bioworks • Bio-Techne • Allogene Therapeutics ...
SEC CIK
Corporate docs
Subsidiaries
Denali BBB Holding Limited • Denali Therapeutics CH GmbH ...
DNLI stock data
News

Stocks That Hit 52-Week Lows On Friday
6 May 22
Denali Therapeutics Q1 EPS $(0.53) Up From $(0.58) YoY, Sales $42.10M Up From $7.92M YoY
5 May 22
Denali Announces Partner Sanofi Has Commenced Dosing In Phase 2 Study Of SAR443820; Denali To Receive $40M Milestone Payment
2 May 22
Stocks That Hit 52-Week Lows On Thursday
28 Apr 22
Stocks That Hit 52-Week Lows On Wednesday
27 Apr 22
Press releases
Denali Therapeutics Reports First Quarter 2022 Financial Results and Business Highlights
5 May 22
Tessera Therapeutics Announces Over $300M Series C Financing to Advance its GENE WRITING Platform
19 Apr 22
Flagship Pioneering Bolsters Executive Team with Appointment of Michelle C. Werner as CEO-Partner and CEO of Alltrna
11 Apr 22
R&D Efforts for Alzheimer's Therapies on the Rise with over 120 Drugs in Development
31 Mar 22
Denali Therapeutics Appoints Alexander Schuth as Chief Operating and Financial Officer as Steve Krognes Transitions to Denali Board of Directors
15 Mar 22
Calendar
4 May 22
20 May 22
31 Dec 22
Financial summary
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Cash burn rate (est.) | Burn method: Change in cash | Burn method: Operating income | Burn method: FCF (opex + capex) | Last Q | Avg 4Q | Last Q | Avg 4Q | Last Q | Avg 4Q |
---|---|---|---|---|---|---|
Cash on hand (at last report) | 106.45M | 106.45M | 106.45M | 106.45M | 106.45M | 106.45M |
Cash burn (monthly) | 62.84M | 27.53M | 22.17M | 24.25M | 24.04M | 19.44M |
Cash used (since last report) | 104.12M | 45.62M | 36.73M | 40.18M | 39.83M | 32.21M |
Cash remaining | 2.33M | 60.84M | 69.73M | 66.27M | 66.63M | 74.25M |
Runway (months of cash) | 0.0 | 2.2 | 3.1 | 2.7 | 2.8 | 3.8 |
Recent insider trades
Date | Owner | Security | Transaction | Code | Indirect | 10b5-1 | $Price | #Shares | $Value | #Remaining |
---|---|---|---|---|---|---|---|---|---|---|
23 Mar 22 | Tessier-Lavigne Marc | Common Stock | Sell | Dispose S | No | No | 34.14 | 11,598 | 395.96K | 2,024,370 |
23 Mar 22 | Tessier-Lavigne Marc | Common Stock | Sell | Dispose S | No | No | 33.4 | 8,402 | 280.63K | 2,035,968 |
11 Feb 22 | Ho Carole | Common Stock | Sell | Dispose S | Yes | No | 34.71 | 2,918 | 101.28K | 170,663 |
11 Feb 22 | Schuth Alexander O. | Common Stock | Sell | Dispose S | Yes | No | 34.68 | 2,803 | 97.21K | 465,047 |
11 Feb 22 | Krognes Steve E. | Common Stock | Sell | Dispose S | No | No | 34.69 | 2,560 | 88.81K | 120,221 |
11 Feb 22 | Watts Ryan J. | Common Stock | Sell | Dispose S | Yes | No | 34.72 | 9,491 | 329.53K | 2,129,648 |
Institutional ownership, Q1 2022
97.5% owned by funds/institutions
13F holders | Current |
---|---|
Total holders | 181 |
Opened positions | 18 |
Closed positions | 50 |
Increased positions | 62 |
Reduced positions | 66 |
13F shares | Current |
---|---|
Total value | 4.35B |
Total shares | 119.85M |
Total puts | 49.9K |
Total calls | 25K |
Total put/call ratio | 2.0 |
Largest owners | Shares | Value |
---|---|---|
Baillie Gifford & Co | 14.98M | $481.92M |
BIIB Biogen | 13.31M | $477.44M |
ARCH Venture Fund VIII | 10.67M | $893.61M |
BLK Blackrock | 8.19M | $263.34M |
Vanguard | 8.11M | $260.96M |
Douglas K Bratton | 7.71M | $0 |
Crestline Management | 7.46M | $240.01M |
Temasek | 5.37M | $172.74M |
TROW T. Rowe Price | 4.92M | $158.39M |
STT State Street | 3.83M | $123.11M |
Financial report summary
?Competition
Biogen • Astrazeneca • Roche • Shire • Cytokinetics • Sanofi • Abbvie • Prothena • Mallinckrodt • Acumen PharmaceuticalsRisks
- Risks Related to Our Business, Financial Condition and Capital Requirements
- We are in the early stages of clinical drug development and have a very limited operating history and no products approved for commercial sale, which may make it difficult to evaluate our current business and predict our future success and viability.
- We have incurred significant net losses since our inception and anticipate that we will continue to incur net losses for the foreseeable future.
- Drug development is a highly uncertain undertaking and involves a substantial degree of risk. We have never generated any revenue from product sales, and we may never generate product revenue or be profitable.
- If we fail to obtain additional financing, we may be unable to complete the development and, if approved, commercialization of our product candidates.
- Due to the significant resources required for the development of our programs, and depending on our ability to access capital, we must prioritize development of certain product candidates. Moreover, we may expend our limited resources on programs that do not yield a successful product candidate and fail to capitalize on product candidates or indications that may be more profitable or for which there is a greater likelihood of success.
- A pandemic, epidemic or outbreak of an infectious disease, such as COVID-19, or the perception of its effects, may materially and adversely affect our business, operations and financial condition.
- The continued impact of the COVID-19 pandemic may materially and adversely affect our business, operations and financial condition.
- Risks Related to the Discovery, Development and Commercialization of Our Product Candidates
- Research and development of biopharmaceutical products is inherently risky. We are heavily dependent on the successful development of our BBB platform technology and the programs currently in our pipeline, which are in the early stages of preclinical and clinical development. We cannot give any assurance that any of our product candidates will receive regulatory, including marketing, approval, which is necessary before they can be commercialized.
- We may not be successful in our efforts to continue to create a pipeline of product candidates or to develop commercially successful products. If we fail to successfully identify and develop additional product candidates, our commercial opportunity may be limited.
- We have concentrated a substantial portion of our research and development efforts on the treatment of neurodegenerative diseases, a field that has seen limited success in drug development. Further, our product candidates are based on new approaches and novel technology, which makes it difficult to predict the time and cost of product candidate development and subsequently obtaining regulatory approval.
- We may encounter substantial delays in our clinical trials, or may not be able to conduct or complete our clinical trials on the timelines we expect, if at all.
- We may encounter difficulties enrolling and/or retaining patients in our clinical trials, and our clinical development activities could thereby be delayed or otherwise adversely affected.
- Our clinical trials may reveal significant adverse events, toxicities, or other side effects and may fail to demonstrate substantial evidence of the safety and efficacy or potency of our product candidates, which would prevent, delay or limit the scope of regulatory approval and commercialization.
- Interim, topline and preliminary data from our clinical trials that we announce or publish from time to time may change as more patient data become available, and are subject to audit and verification procedures that could result in material changes in the final data.
- We face significant competition in an environment of rapid technological and scientific change, and there is a possibility that our competitors may achieve regulatory approval before us or develop therapies that are safer, more advanced or more effective than ours, which may negatively impact our ability to successfully market or commercialize any product candidates we may develop and ultimately harm our financial condition.
- The manufacture of our product candidates, particularly those that utilize our BBB platform technology, is complex and we may encounter difficulties in production. If we or any of our third-party manufacturers encounter such difficulties, or fail to meet rigorously enforced regulatory standards, our ability to provide supply of our product candidates for clinical trials or our products for patients, if approved, could be delayed or stopped, or we may be unable to maintain a commercially viable cost structure.
- If, in the future, we are unable to establish sales and marketing capabilities or enter into agreements with third parties to sell and market any product candidates we may develop, we may not be successful in commercializing those product candidates if and when they are approved.
- Even if any product candidates we develop receive marketing approval, they may fail to achieve the degree of market acceptance by physicians, patients, healthcare payors, and others in the medical community necessary for commercial success.
- Even if we are able to commercialize any product candidates, such products may become subject to unfavorable pricing regulations, third-party reimbursement practices, or healthcare reform initiatives, which would harm our business.
- If any of our small molecule product candidates obtain regulatory approval, additional competitors could enter the market with generic versions of such drugs, which may result in a material decline in sales of affected products.
- Our biologic, or large molecule, product candidates for which we intend to seek approval may face competition sooner than anticipated.
- If product liability lawsuits are brought against us, we may incur substantial liabilities and may be required to limit commercialization of our product candidates.
- Risks Related to Regulatory Approval and Other Legal Compliance Matters
- The regulatory approval processes of the FDA, EMA and comparable foreign regulatory authorities are lengthy, time consuming, and inherently unpredictable. If we are ultimately unable to obtain regulatory approval for our product candidates, we will be unable to generate product revenue and our business will be substantially harmed.
- Our product candidates may cause undesirable side effects or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences.
- We currently conduct clinical trials for our product candidates outside the United States, and may in the future conduct clinical trials outside of the United States, and the FDA, EMA and applicable foreign regulatory authorities may not accept data from such trials.
- Obtaining and maintaining regulatory approval of our product candidates in one jurisdiction does not mean that we will be successful in obtaining regulatory approval of our product candidates in other jurisdictions.
- Even if we obtain regulatory approval for a product candidate, our products will remain subject to extensive regulatory scrutiny.
- We have received orphan drug designation from the FDA for DNL310, and plan to seek orphan drug designation for additional product candidates, but we may be unable to obtain such designations or to maintain the benefits associated with orphan drug status, including market exclusivity, which may cause our revenue, if any, to be reduced.
- Our employees, independent contractors, consultants, commercial partners and vendors may engage in misconduct or other improper activities, including noncompliance with regulatory standards and requirements.
- If we fail to comply with healthcare laws, we could face substantial penalties and our business, operations and financial conditions could be adversely affected.
- Our business is subject to complex and evolving U.S. and foreign laws and regulations, information security policies and contractual obligations relating to privacy and data protection, including the use, processing, and cross-border transfer of personal information. These laws and regulations are subject to change and uncertain interpretation, and could result in claims, changes to our business practices, or monetary penalties, and otherwise may harm our business.
- If we or any contract manufacturers and suppliers we engage fail to comply with environmental, health, and safety laws and regulations, we could become subject to fines or penalties or incur costs that could have a material adverse effect on the success of our business.
- Our business activities may be subject to the Foreign Corrupt Practices Act and similar anti-bribery and anti-corruption laws, as well as U.S. and certain foreign export controls, trade sanctions, and import laws and regulations.
- Inadequate funding for the FDA, the SEC and other government agencies could hinder their ability to hire and retain key leadership and other personnel, prevent new products and services from being developed or commercialized in a timely manner or otherwise prevent those agencies from performing normal business functions on which the operation of our business may rely, which could negatively impact our business.
- Risks Related to Our Reliance on Third Parties
- We expect to depend on collaborations with third parties for the research, development and commercialization of certain of the product candidates we may develop. If any such collaborations are not successful, we may not be able to realize the market potential of those product candidates.
- We expect to rely on third parties to conduct our clinical trials and some aspects of our research and preclinical testing, and those third parties may not perform satisfactorily, including failing to meet deadlines for the completion of such trials, research, or testing.
- We currently contract with third parties for the manufacture of the significant majority of the materials for our research programs, preclinical studies and clinical trials and expect to continue to do so for commercialization of some or all product candidates that we may develop. This reliance on third parties may increase the risk that we will not have sufficient quantities of such materials, product candidates, or any medicines that we may develop and commercialize, or that such supply will not be available to us at an acceptable cost, which could delay, prevent, or impair our development or commercialization efforts.
- We depend on third-party suppliers for key raw materials used in our manufacturing processes, and the loss of these third-party suppliers or their inability to supply us with adequate raw materials could harm our business.
- If we are unable to obtain and maintain patent protection for any product candidates we develop or for our BBB platform technology, our competitors could develop and commercialize products or technology similar or identical to ours, and our ability to successfully commercialize any product candidates we may develop, and our technology may be adversely affected.
- If any of our owned or in-licensed patent applications do not issue as patents in any jurisdiction, we may not be able to compete effectively.
- If the scope of any patent protection we obtain is not sufficiently broad, or if we lose any of our patent protection, our ability to prevent our competitors from commercializing similar or identical technology and product candidates would be adversely affected.
- Our rights to develop and commercialize our BBB platform technology and product candidates are subject, in part, to the terms and conditions of licenses granted to us by others or licenses granted by us to others.
- If we fail to comply with our obligations in the agreements under which we license intellectual property rights from third parties or otherwise experience disruptions to our business relationships with our licensors, we could lose license rights that are important to our business.
- We may not be able to protect our intellectual property and proprietary rights throughout the world.
- Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment, and other requirements imposed by government patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.
- Changes in U.S. patent law could diminish the value of patents in general, thereby impairing our ability to protect our products.
- Issued patents covering our BBB platform technology, product candidates and other technologies could be found invalid or unenforceable if challenged in court or before administrative bodies in the United States or abroad.
- If we do not obtain patent term extension and data exclusivity for any product candidates we may develop, our business may be materially harmed.
- We may be subject to claims challenging the inventorship of our patents and other intellectual property.
- If we are unable to protect the confidentiality of our trade secrets, our business and competitive position would be harmed.
- We may not be successful in obtaining, through acquisitions, in-licenses or otherwise, necessary rights to our BBB platform technology, product candidates or other technologies.
- We may be subject to claims that our employees, consultants, or advisors have wrongfully used or disclosed alleged trade secrets of their current or former employers or claims asserting ownership of what we regard as our own intellectual property.
- Third-party claims of intellectual property infringement, misappropriation or other violation against us, our licensors or our collaborators may prevent or delay the development and commercialization of our BBB platform technology, product candidates and other technologies.
- We may become involved in lawsuits to protect or enforce our patents and other intellectual property rights, which could be expensive, time consuming, and unsuccessful.
- If our trademarks and trade names are not adequately protected, then we may not be able to build name recognition in our markets of interest and our business may be adversely affected.
- Intellectual property rights do not necessarily address all potential threats.
- We are highly dependent on our key personnel, and if we are not successful in attracting, motivating and retaining highly qualified personnel, we may not be able to successfully implement our business strategy.
- We will need to grow the size and capabilities of our organization, and we may experience difficulties in managing this growth.
- We have engaged in and may in the future engage in acquisitions or strategic partnerships, which may increase our capital requirements, dilute our stockholders, cause us to incur debt or assume contingent liabilities, and subject us to other risks.
- Business disruptions could seriously harm our future revenue and financial condition and increase our costs and expenses.
- Our business is subject to economic, political, regulatory and other risks associated with international operations.
- Our ability to use our net operating loss carryforwards and certain other tax attributes may be limited.
- We may be subject to adverse legislative or regulatory tax changes that could negatively impact our financial condition.
- The market price of our common stock has been and may continue to be volatile, which could result in substantial losses for investors.
- If securities analysts do not publish research or reports about our business or if they publish negative evaluations of our stock, the price of our stock and trading volume could decline.
- Sales of substantial amounts of our common stock in the public markets, or the perception that such sales might occur, could cause the market price of our common stock to decline significantly, even if our business is doing well.
- Raising additional capital may cause dilution to our existing stockholders, restrict our operations or require us to relinquish rights to our technologies or product candidates.
- Our principal stockholders and management own a significant percentage of our stock and will be able to exercise significant influence over matters subject to stockholder approval.
- If we are unable to maintain effective internal controls, our business, financial position and results of operations and growth prospects could be adversely affected.
- Our disclosure controls and procedures may not prevent or detect all errors or acts of fraud.
- We have not paid and do not expect to pay any dividends for the foreseeable future. Any return on investment may be limited to the value of our common stock. Investors may never obtain a return on their investment.
- Delaware law and provisions in our charter documents might discourage, delay, or prevent a change in control of our company or changes in our management and, therefore, depress the trading price of our common stock.
- Our amended and restated certificate of incorporation provides that the Court of Chancery of the State of Delaware and the federal district courts of the United States of America will be the exclusive forums for substantially all disputes between us and our stockholders, which could limit our stockholders’ ability to obtain a favorable judicial forum for disputes with us or our directors, officers, or employees.
Management Discussion
- *Percentage is not meaningful.
- Collaboration revenue. Collaboration revenue was $42.1 million and $7.9 million for the three months ended March 31, 2022 and 2021, respectively. The increase in collaboration revenue of $34.2 million for the three months ended March 31, 2022 compared to the three months ended March 31, 2021 was primarily due to an increase in revenue from our collaborations with Takeda and Biogen of $32.9 million and $1.3 million, respectively. Takeda revenue for the three months ended March 31, 2022 is composed of $27.9 million recognized due to the performance obligation satisfaction associated with termination of the Tau program, and $12.0 million related to the milestone earned for approval of the CTA for TAK-594/DNL593 (PTV:PGRN).
- Research and development expenses. Research and development expenses were $86.1 million and $60.2 million for the three months ended March 31, 2022 and 2021, respectively.
Content analysis
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H.S. junior Avg
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New words:
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Removed:
ASU, cerebrospinal, cohort, concept, declining, eliminating, FASB, filling, function, GAG, Gaucher, GLP, heading, IIIB, intraperiod, joined, leukodystrophy, metachromatic, MLD, monkey, Parkinsonism, Pompe, positive, Pronouncement, proof, prospectively, rat, retained, shelter, simplify, Simplifying, thought, twelve, Virtual
Financial reports
Current reports
8-K
Denali Therapeutics Reports First Quarter 2022 Financial Results and Business Highlights
5 May 22
8-K
Denali Therapeutics Appoints Alexander Schuth as Chief Operating and Financial
16 Mar 22
8-K
Entry into a Material Definitive Agreement
28 Feb 22
8-K
Denali Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Business Highlights
28 Feb 22
8-K
Regulation FD Disclosure
14 Feb 22
8-K
Other Events
10 Feb 22
8-K
Denali Therapeutics Announces Appointment of Erik Harris to Board of Directors
7 Feb 22
8-K
Denali Therapeutics Announces Progression and Expansion of Broad Therapeutic Portfolio for Neurodegeneration and Expected Key Milestones in 2022
10 Jan 22
8-K
Regulation FD Disclosure
17 Nov 21
8-K
Denali Therapeutics Reports Third Quarter 2021 Financial Results and Business Highlights
4 Nov 21
Registration and prospectus
S-3ASR
Automatic shelf registration
28 Feb 22
S-8
Registration of securities for employees
28 Feb 22
S-8
Registration of securities for employees
26 Feb 21
S-8
Registration of securities for employees
27 Feb 20
424B5
Prospectus supplement for primary offering
29 Jan 20
424B5
Prospectus supplement for primary offering
27 Jan 20
S-3ASR
Automatic shelf registration
13 Mar 19
S-8
Registration of securities for employees
12 Mar 19
424B4
Prospectus supplement with pricing info
7 Dec 17
S-8
Registration of securities for employees
7 Dec 17
Proxies
DEFA14A
Additional proxy soliciting materials
19 Apr 22
DEFA14A
Additional proxy soliciting materials
22 Apr 21
DEFA14A
Additional proxy soliciting materials
22 Apr 20
DEFA14A
Additional proxy soliciting materials
18 Apr 19
DEFA14A
Additional proxy soliciting materials
26 Apr 18
DEF 14A
Definitive proxy
26 Apr 18
Other
UPLOAD
Letter from SEC
6 Oct 19
CORRESP
Correspondence with SEC
10 Sep 19
UPLOAD
Letter from SEC
15 Aug 19
CORRESP
Correspondence with SEC
15 Jul 19
UPLOAD
Letter from SEC
1 Jul 19
CT ORDER
Confidential treatment order
25 Mar 19
CT ORDER
Confidential treatment order
21 Feb 19
CT ORDER
Confidential treatment order
19 Nov 18
CT ORDER
Confidential treatment order
16 Jul 18
CT ORDER
Confidential treatment order
7 Dec 17
Ownership
4
Denali Therapeutics / Marc Tessier-Lavigne ownership change
25 Mar 22
5
Denali Therapeutics / Marc Tessier-Lavigne ownership change
17 Feb 22
4
Denali Therapeutics / Ryan J. Watts ownership change
15 Feb 22
4
Denali Therapeutics / Steve E. Krognes ownership change
15 Feb 22
4
Denali Therapeutics / Alexander O. Schuth ownership change
15 Feb 22
4
Denali Therapeutics / Carole Ho ownership change
15 Feb 22
3/A
Denali Therapeutics / Erik Harris ownership change
14 Feb 22
SC 13G/A
Denali Therapeutics / BRATTON DOUGLAS K ownership change
14 Feb 22
SC 13G/A
Denali Therapeutics / PRICE T ROWE ASSOCIATES ownership change
13 Feb 22
4
Denali Therapeutics / Steve E. Krognes ownership change
11 Feb 22
Patents
Utility
Compounds, Compositions, and Methods
5 May 22
The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
Utility
Compound, Compositions, and Methods
21 Apr 22
Compounds having activity as LRRK2 inhibitors are disclosed.
Utility
ANTI-TREM2 Antibodies and Methods of Use Thereof
21 Apr 22
In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided.
Utility
Compounds, compositions and methods
19 Apr 22
The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
Utility
ANTI-TREM2 Antibodies and Methods of Use Thereof
10 Mar 22
In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided.
Reddit threads
Daily Discussion Thread - May 6th, 2022
6 May 22
Daily Discussion Thread - May 2nd, 2022
2 May 22
Daily Discussion Thread - April 29th, 2022
29 Apr 22
Daily Discussion Thread - February 24th, 2022
24 Feb 22
Daily Discussion Thread - February 23rd, 2022
23 Feb 22
Daily Discussion Thread - February 22nd, 2022
22 Feb 22
Daily Discussion Thread - February 21st, 2022
21 Feb 22
Breakouts and Breakdowns Scanner Thread for January 27th, 2022
27 Jan 22
Breakouts and Breakdowns Scanner Thread for January 26th, 2022
26 Jan 22
Breakouts and Breakdowns Scanner Thread for January 25th, 2022
25 Jan 22