APTO Aptose Biosciences

Aptose Biosciences is a clinical-stage biotechnology company committed to developing personalized therapies addressing unmet medical needs in oncology, with an initial focus on hematology. The Company's small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities. The Company has two clinical-stage investigational products for hematologic malignancies: CG-806, an oral, first-in-classmutation-agnostic FLT3/BTK kinase inhibitor, is in a Phase 1 trial in patients with relapsed or refractory B cell malignancies, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and non-Hodgkin lymphoma (NHL), who have failed or are intolerant to standard therapies, and is in a separate Phase 1 trial in patients with relapsed or refractory acute myeloid leukemia (AML); APTO-253, the only known clinical stage agent that directly targets the MYC oncogene and suppresses its expression, is in a Phase 1b clinical trial for the treatment of patients with relapsed or refractory AML or high risk myelodysplastic syndrome (MDS).

Company profile

William Rice
Fiscal year end
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APTO stock data


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4 May 21
2 Aug 21
31 Dec 21
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Financial data from company earnings reports.

Cash burn rate (estimated) Burn method: Change in cash Burn method: Operating income/loss Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 87.08M 87.08M 87.08M 87.08M 87.08M 87.08M
Cash burn (monthly) 10.1M (positive/no burn) 5.42M 5.02M 3.46M 3.01M
Cash used (since last report) 41.28M n/a 22.13M 20.49M 14.13M 12.31M
Cash remaining 45.8M n/a 64.95M 66.59M 72.95M 74.77M
Runway (months of cash) 4.5 n/a 12.0 13.3 21.1 24.8

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
2 Jul 21 Rice William G. Common shares Buy Aquire P No No 3.2886 6,081 20K 303,604
22 Jun 21 Whitehead Warren Common Shares Sell Dispose S No No 3.24 9,600 31.1K 15,000
21 Jun 21 Whitehead Warren Common Shares Sell Dispose S No No 3.35 15,400 51.59K 24,600
4 Jan 21 Ashe Carol Gail Director Stock Option Common Shares Grant Aquire A No No 4.37 50,000 218.5K 50,000
4 Jan 21 Rafael Bejar Employee Stock Option Common Shares Grant Aquire A No No 4.37 343,000 1.5M 343,000
4 Jan 21 Burger Denis R Director Stock Option Common Shares Grant Aquire A No No 4.37 50,000 218.5K 50,000

Data for the last complete 13F reporting period. To see the most recent changes to ownership, click the ownership history button above.

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Financial report summary

Viracta Therapeutics
Management Discussion
  • Net loss of $55.2 million for the year ended December 31, 2020 increased by approximately $28.9 million as compared with $26.3 million for the year ended December 31, 2019, primarily as a result of an increase of $19.1 million in stock-based compensation in the current period, a combined increase in program costs and related labor costs of approximately $9.8 million on our luxeptinib development program and higher cash-based general and administrative expenses of approximately $549 thousand. These expenses were partially offset by lower costs of $545 thousand on our APTO-253 development programs.
  • R&D expenses increased by $12.5 million to $29.3 million for the year ended December 31, 2020 as compared with $16.8 million for the comparative period in 2019. Changes to the components of our R&D expenses presented in the table above are primarily as a result of the following activities:
  • General and administrative expenses for the year ended December 31, 2020 were approximately $26.5 million as compared with $10.0 million for the comparative period in 2019, an increase of approximately $16.5 million. The increase was primarily as a result of the following:
Content analysis
H.S. sophomore Avg
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