Docoh
Loading...

EXEL Exelixis

Founded in 1994, Exelixis, Inc. is a commercially successful, oncology-focused biotechnology company that strives to accelerate the discovery, development and commercialization of new medicines for difficult-to-treat cancers. Following early work in model system genetics, it established a broad drug discovery and development platform that has served as the foundation for its continued efforts to bring new cancer therapies to patients in need. Its discovery efforts have resulted in four commercially available products, CABOMETYX® (cabozantinib), COMETRIQ® (cabozantinib), COTELLIC® (cobimetinib) and MINNEBRO® (esaxerenone), and it has entered into partnerships with leading pharmaceutical companies to bring these important medicines to patients worldwide. Supported by revenues from its marketed products and collaborations, it is committed to prudently reinvesting in its business to maximize the potential of its pipeline. It is supplementing its existing therapeutic assets with targeted business development activities and internal drug discovery - all to deliver the next generation of Exelixis medicines and help patients recover stronger and live longer. Exelixis is a member of the Standard & Poor's (S&P) MidCap 400 index, which measures the performance of profitable mid-sized companies. In November 2020, the company was named to Fortune's 100 Fastest-Growing Companies list for the first time, ranking 17th overall and the third-highest biopharmaceutical company.

Company profile

Ticker
EXEL
Exchange
CEO
Michael M. Morrissey
Employees
Incorporated
Location
Fiscal year end
Former names
EXELIXIS INC
SEC CIK
IRS number
43257395

EXEL stock data

(
)

Calendar

6 May 21
2 Aug 21
31 Dec 21
Quarter (USD)
Apr 21 Jan 21 Oct 20 Jul 20
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Annual (USD)
Jan 21 Jan 20 Dec 18 Dec 17
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS

Financial data from Exelixis earnings reports.

Cash burn rate (estimated) Burn method: Change in cash Burn method: Operating income/loss Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 419.92M 419.92M 419.92M 419.92M 419.92M 419.92M
Cash burn (monthly) (positive/no burn) (positive/no burn) 1.54M (positive/no burn) (positive/no burn) (positive/no burn)
Cash used (since last report) n/a n/a 6.19M n/a n/a n/a
Cash remaining n/a n/a 413.73M n/a n/a n/a
Runway (months of cash) n/a n/a 269.4 n/a n/a n/a

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
26 Jul 21 Gisela Schwab Common Stock Option exercise Aquire M No No 4.2 40,000 168K 689,078
26 Jul 21 Gisela Schwab Option Common Stock Option exercise Dispose M No No 4.2 40,000 168K 0
21 Jul 21 Gisela Schwab Common Stock Option exercise Aquire M No No 4.2 35,000 147K 649,078
21 Jul 21 Gisela Schwab Option Common Stock Option exercise Dispose M No No 4.2 35,000 147K 40,000
15 Jul 21 Lamb Peter Common Stock Sell Dispose S No Yes 17.47 60,000 1.05M 389,467
15 Jul 21 Lamb Peter Common Stock Option exercise Aquire M No No 1.9 60,000 114K 449,467
15 Jul 21 Lamb Peter Option Common Stock Option exercise Dispose M No No 1.9 60,000 114K 55,000
6 Jul 21 Charles Cohen Common Stock Option exercise Aquire M No No 6.3 40,000 252K 261,375
6 Jul 21 Charles Cohen Common Stock Option exercise Aquire M No No 3.13 40,000 125.2K 221,375
6 Jul 21 Charles Cohen Option Common Stock Option exercise Dispose M No No 6.3 40,000 252K 0

Data for the last complete 13F reporting period. To see the most recent changes to ownership, click the ownership history button above.

82.3% owned by funds/institutions
13F holders
Current Prev Q Change
Total holders 336 342 -1.8%
Opened positions 50 45 +11.1%
Closed positions 56 64 -12.5%
Increased positions 109 130 -16.2%
Reduced positions 117 112 +4.5%
13F shares
Current Prev Q Change
Total value 6.23B 5.6B +11.2%
Total shares 257.89M 260.16M -0.9%
Total puts 666.1K 1.26M -47.2%
Total calls 773K 698.7K +10.6%
Total put/call ratio 0.9 1.8 -52.2%
Largest owners
Shares Value Change
BLK Blackrock 32.11M $725.37M +2.3%
Vanguard 29.4M $664.15M +3.3%
TROW T. Rowe Price 20.73M $468.39M +17.9%
Renaissance Technologies 18.63M $420.92M -14.1%
FMR 15.16M $342.41M +18.9%
JPM JPMorgan Chase & Co. 11.36M $256.67M -2.6%
Meditor 11.28M $254.72M -10.6%
Farallon Capital Management 10.75M $242.84M -2.3%
STT State Street 9.24M $208.74M -9.6%
Pictet Asset Management 6.06M $136.99M -4.3%
Largest transactions
Shares Bought/sold Change
Citadel Advisors 3.66M +3.53M +2789.2%
TROW T. Rowe Price 20.73M +3.15M +17.9%
Renaissance Technologies 18.63M -3.05M -14.1%
Norges Bank 0 -3.03M EXIT
FMR 15.16M +2.41M +18.9%
Assenagon Asset Management 351.79K -1.86M -84.1%
Point72 Asset Management 1.69M -1.69M -50.0%
Meditor 11.28M -1.33M -10.6%
Sectoral Asset Management 490.06K -1.31M -72.8%
DB Deutsche Bank AG - Registered Shares 1.33M +1.16M +666.8%

Financial report summary

?
Risks
  • Our ability to grow our company is critically dependent upon the commercial success of CABOMETYX in its approved indications and the further clinical development, regulatory approval and commercial success of the cabozantinib franchise in additional indications.
  • Our ability to grow revenues from sales of CABOMETYX will depend upon the degree of market acceptance among physicians, patients, healthcare payers, and the medical community.
  • Our competitors may develop products, combination therapies and technologies that impair the relative value of our marketed products and any future product candidates.
  • If we are unable to maintain or increase our sales, marketing, market access and product distribution capabilities for our products, we may be unable to maximize product revenues, which could have a material adverse impact on our business, financial condition and results of operations.
  • If we are unable to obtain or maintain coverage and reimbursement for our products from third-party payers, our business will suffer.
  • Current healthcare laws and regulations in the U.S. and future legislative or regulatory reforms to the U.S. healthcare system may affect our ability to commercialize our marketed products profitably.
  • Pricing for pharmaceutical products in the U.S. has come under increasing attention and scrutiny by federal and state governments, legislative bodies and enforcement agencies. This may result in actions that have the effect of reducing our revenue or harming our business or reputation.
  • Lengthy regulatory pricing and reimbursement procedures and cost control initiatives imposed by governments outside the U.S. could delay the marketing of and/or result in downward pressure on the price of our approved products, resulting in a decrease in revenue.
  • Legislation and regulatory action designed to reduce barriers to the development, approval and adoption of generic drugs in the U.S., and the entrance of generic competitors, could limit the revenue we derive from our products, which could have a material adverse impact on our business, financial condition and results of operations.
  • We are subject to healthcare laws, regulations and enforcement; our failure to comply with those laws could have a material adverse impact on our business, financial condition and results of operations.
  • We are subject to laws and regulations relating to privacy, data protection and the collection and processing of personal data. Failure to maintain compliance with these regulations could create additional liabilities for us.
  • Clinical testing of cabozantinib for new indications, or of new product candidates, is a lengthy, costly, complex and uncertain process that may fail ultimately to demonstrate safety and efficacy data for those products sufficiently differentiated to compete in our highly competitive market environment.
  • The regulatory approval processes of the FDA and comparable foreign regulatory authorities are lengthy and uncertain and may not result in regulatory approvals for additional cabozantinib indications or our other product candidates, which could have a material adverse impact on our business, financial condition and results of operations.
  • We may be unable to expand our development pipeline, which could limit our growth and revenue potential.
  • Our profitability could be negatively impacted if expenses associated with our extensive clinical development, business development and commercialization activities, both for the cabozantinib franchise and our earlier-stage product candidates, grow more quickly than the revenues we generate.
  • If additional capital is not available to us when we need it, we may be unable to expand our product offerings and maintain business growth.
  • We rely on Ipsen and Takeda for the commercial success of CABOMETYX in its approved indications outside of the U.S., and are unable to control the amount or timing of resources expended by these collaboration partners in the commercialization of CABOMETYX in its approved indications outside of the U.S.
  • Our clinical, regulatory and commercial collaborations with major companies make us reliant on those companies for their continued performance and investments, which subjects us to a number of risks.
  • Our growth potential is dependent in part upon companies with which we have entered into research collaborations, in-licensing arrangements and similar business development relationships.
  • If third parties upon which we rely to perform clinical trials for cabozantinib in new indications or for new product candidates do not perform as contractually required or expected, we may not be able to obtain regulatory approval for or commercialize cabozantinib or other product candidates beyond currently approved indications.
  • We lack our own manufacturing and distribution capabilities necessary for us to produce materials required for certain preclinical activities and to produce and distribute our products for clinical development or for commercial sale, and our reliance on third parties for these services subjects us to various risks.
  • If third-party scientific advisors and contractors we rely on to assist with our drug discovery efforts do not perform as expected, the expansion of our product pipeline may be delayed.
  • Data breaches, cyber-attacks and other failures in our information technology operations and infrastructure could compromise our intellectual property or other sensitive information, damage our operations and cause significant harm to our business and reputation.
  • If we are unable to adequately protect our intellectual property, third parties may be able to use our technology, which could adversely affect our ability to compete in the market.
  • Litigation or third-party claims of intellectual property infringement could require us to spend substantial time and money and adversely affect our ability to develop and commercialize products.
  • If the COVID-19 pandemic is further prolonged or becomes more severe, our business operations and corresponding financial results could suffer, which could have a material adverse impact on our financial condition and prospects for growth.
  • If we are unable to manage our growth, there could be a material adverse impact on our business, financial condition and results of operations, and our prospects may be adversely affected.
  • The loss of key personnel or the inability to retain and, where necessary, attract additional personnel could impair our ability to operate and expand our operations.
  • We use hazardous chemicals and biological materials in our business. Any claims relating to improper handling, storage or disposal of these materials could be time consuming and costly.
  • We face potential product liability exposure far in excess of our limited insurance coverage.
  • Our stock price has been and may in the future be highly volatile.
  • Anti-takeover provisions in our charter documents and under Delaware law could make an acquisition of us, which may be beneficial to our stockholders, more difficult and may prevent or deter attempts by our stockholders to replace or remove our current management, which could cause the market price of our common stock to decline.
Management Discussion
  • During the first quarter of 2021, we continued to execute on our business objectives, generating significant revenues from operations and enabling us to continue to seek to maximize the clinical and commercial potential of our products and expand our product pipeline. Significant business updates and financial highlights for the quarter and subsequent to quarter-end include:
  • •In January 2021, the FDA approved the combination of CABOMETYX and OPDIVO as a first-line treatment of patients with advanced RCC, and we commenced the commercial launch of the combination upon such approval. The approval was based on positive results from the phase 3 pivotal trial, CheckMate -9ER, in which the combination met its primary endpoint of significantly improving PFS at final analysis, as well as the secondary endpoints of OS at a pre-specified interim analysis and ORR, versus sunitinib.
  • •In January 2021, we announced the initiation of a phase 1 clinical trial evaluating XL102, both as a single agent and in combination with other anti-cancer therapies for the treatment of inoperable, locally advanced or metastatic solid tumors.
Content analysis
?
Positive
Negative
Uncertain
Constraining
Legalese
Litigous
Readability
H.S. junior Avg
New words: Adagene, AKS, Answer, avelumab, Biden, Bio, brain, Breakthrough, Bristol, burdened, Carlo, Cayman, complicate, construction, CPRA, Darmstadt, declaratory, denominated, denying, disadvantage, doubling, drawn, EC, emerge, emergence, Euro, FASB, fewer, fixed, framework, Germany, guarantee, harbor, hedge, hedging, histology, identification, implicated, inflammation, iodine, KGaA, KGgA, library, masked, MER, Merck, metabolic, monoclonal, Monte, multicenter, NASDAQ, panel, papillary, PAPMET, peer, percent, percentile, Pfizer, pharmacy, plc, quickly, radioactive, rank, refractory, reliance, rest, revert, role, safe, SAFEbody, SAFEbodyTM, sarcomatoid, shareholder, short, simulation, Southwest, speculative, standby, strong, subgroup, subsidiary, SWOG, tenant, Teva, trend, TSR, UC, uptake, USA, vaccinated, workplace, WuXi
Removed: achieving, adapted, adequacy, adjust, adjustment, administering, administrable, adulterated, affecting, aging, Aid, aircraft, airport, alpha, altogether, amendment, amortized, annually, appeal, applied, applying, assessing, attack, attempting, authoritative, Bay, billed, biology, Brexit, brought, bundle, bundled, Cadillac, Casein, catastrophic, cautioned, Children, Circuit, circumstance, classification, clinic, clinically, closure, Code, collaborated, collected, commerce, communicate, communication, comparison, complement, comprehensive, conceal, conclude, conditioned, consistently, constraint, continuity, cooperation, counterparty, cumulative, cyber, danger, deemed, default, defaulted, demonstrated, detect, device, disaster, discounted, discounting, distinct, distributing, diversify, divided, earthquake, Education, educational, eliminating, encouraged, enterprise, entirety, espionage, estimated, exacerbating, EXAMINER, exclude, existence, explained, extend, Facebook, family, forecast, forecasted, Francisco, fraudulent, frequency, fundamental, Gastrointestinal, goodwill, grew, hacker, hamper, harder, hazard, identified, image, inappropriate, inception, incorrect, indefinitely, individual, insurer, interpretation, interstate, Invenra, invoiced, isolated, Judge, Kingdom, knowingly, led, left, licensee, light, literature, malpractice, mandate, meaningful, measuring, media, medicinal, misbranded, mix, motive, move, multispecific, natural, navigate, negotiating, nonpublic, nonrefundable, Northern, Notably, occasion, occurrence, oncologic, orally, outlook, pace, packaging, Parliament, pathway, people, permanently, pharmacology, physical, physician, power, precedent, predominant, preparing, presenting, President, progressing, prosecution, prospective, proximity, psychological, publicly, publish, published, quantitative, qui, radioiodine, ransomware, ratification, ratio, rational, reach, reached, reauthorized, recognizing, recover, recoverable, regimen, reimbursable, reinvesting, remanded, renew, repealed, request, requiring, resolved, resume, retrospectively, ruled, ruling, sabotage, San, selecting, separate, settlement, Simplifying, smaller, stage, StemSynergy, step, store, storing, Sunshine, supportable, Supreme, sustain, sustained, systemic, tam, tangible, taxable, teaching, terrorism, test, theft, transferred, transition, Trump, Twitter, typically, UK, unavailable, unbilled, unconstitutional, unexpected, unforeseeable, unit, unused, upheld, user, utilized, variation, violated, website, widespread, wrongfully

Patents

GRANT
Utility
Drug combinations to treat multiple myeloma
20 Jul 21
This invention relates to the combination of a C-Met inhibitor and a proteasome inhibitor to treat cancer, particularly multiple myeloma.
APP
Utility
Crystalline Solid Forms of N-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, Processes for Making, and Methods of Use
8 Jul 21
The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer.
APP
Utility
Crystalline Solid Forms of N-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, Processes for Making, and Methods of Use
1 Jul 21
The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer.
APP
Utility
Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds
3 Jun 21
Inventors: Jo Ann Wilson, Khalid Shah
APP
Utility
Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
3 Jun 21
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts.