UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

FORM 10-K/A

(Amendment No. 1)

 

xxANNUAL REPORT UNDERPURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the fiscal year ended December 31, 20152023

 

¨¨TRANSITION REPORT UNDERPURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the transition period from ______to _______

Commission File Number: 001-35737

 

NORTHWEST BIOTHERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

 

Delaware

Delaware

94-3306718
(State or Other Jurisdiction of Incorporation or Organization)

 

94-3306718

(I.R.S. Employer Identification No.)

 

4800 Montgomery Lane, Suite 800, Bethesda, MD20814

(Address of principal executive offices) (Zip Code)

 

(240) (240) 497-9024

(Registrant'sRegistrant’s telephone number)

N/A

(Former Name, Former Address and Former Fiscal Year, if changed since last report)number, including area code)

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each classclass:Trading Symbol(s):Name of each exchange on which registeredregistered:
Common Stock, $0.001 par value $0.001 per shareNWBOThe NASDAQ Capital Market
Warrants to purchase Common StockThe NASDAQ Capital MarketOTCQB

 

Securities registered pursuant to sectionSection 12(g) of the Act:None

 

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ¨Nox

 

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ¨Nox

 

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 (the "Exchange Act"“Exchange Act”) during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yesx  No ¨

 

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). YesxNo ¨

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant's knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. ¨

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company, or an emerging growth company. See definitions of "large“large accelerated filer," "accelerated” “accelerated filer,"” “smaller reporting company” and "smaller reporting company"“emerging growth company” in Rule 12b-2 of the Exchange Act. (Check one):

 

Large accelerated filer¨xAccelerated filerx¨
Non-accelerated filerNon- accelerated filer ¨Smaller reporting company¨
  (Do not check if a smaller reporting company)Emerging growth company¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. x

If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ¨

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). ¨

 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨Nox

 

The aggregate market value of the voting and non-voting common equity held by non-affiliates of the registrant was $244,870,374approximately $617,219,000 on June 30, 2015.2023.

 

As of April 29, 2016,1, 2024, the registrant had 101,740,4401,195,357,817 shares of common stock outstanding.

 

DOCUMENTS INCORPORATED BY REFERENCE

 

None.

 

 

 

 

EXPLANATORY NOTE

On March 5, 2024, Northwest Biotherapeutics, Inc. (the “Company”) filed its Annual Report on Form 10-K for the fiscal year ended December 31, 2023 (the “Original Form 10-K”). This Amendment No. 1 (the “Amendment”) amends Part III, Items 10 through 14 of the Original Form 10-K to include information previously omitted from the Original Form 10-K in reliance on General Instruction G(3) to Form 10-K. General Instruction G(3) to Form 10-K provides that registrants may incorporate by reference certain information from a definitive proxy statement that involves the election of directors if such definitive proxy statement is filed with the Securities and Exchange Commission within 120 days after the end of the fiscal year, or, if such statement is not filed by 120 days after the end of the fiscal year, then by amendment of the annual report. Accordingly, Part III of the Original Form 10-K is hereby amended as set forth below.

In addition, as required by Rule 12b-15 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), new certifications by our principal executive officer and principal financial officer are filed as exhibits to this Amendment under Item 15 of Part IV hereof, which has been restated in its entirety.

Except as stated herein, this Amendment does not reflect events occurring after the filing of the Original Form 10-K with the Securities and Exchange Commission on March 5, 2024 and no attempt has been made in this Amendment to modify or update other disclosures as presented in the Original Form 10-K.


NORTHWEST BIOTHERAPEUTICS, INC.

FORM 10-K

TABLE OF CONTENTS

Explanatory NotePART III i
 
PART II
Item 9B.10.Other Information1
PART III
Item 10.Directors, Executive Officers and Corporate Governance24
Item 11.Executive Compensation4
Item 11.Executive Compensation8
Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters716
Item 13.Certain Relationships and Related Transactions, and Director Independence818
Item 14.Principal Accountant Fees and Services820
​ ​
PART IV
Item 15.Exhibits and Financial Statement Schedules20
   
PART IV 
Item 15.SIGNATURESExhibits and Financial Statement Schedules239

 


In this Amendment No. 1 to the registrant’s Annual Report on Form 10-K/A, unless the context otherwise requires, “Northwest Biotherapeutics,” the “Company,” “we,” “us,” “our” and similar names refer to Northwest Biotherapeutics, Inc. DCVax® is a registered trademark of the Company.

EXPLANATORY NOTE

We are filing this Amendment No. 1 on Form 10-K/A (this “Amendment”) to our annual report on Form 10-K for the fiscal year ended December 31, 2015 (the “Original Filing” or “Form 10-K”), which was originally filed with the Securities and Exchange Commission (the “SEC”) on March 16, 2016, solely to set forth information required by Items 10, 11, 12, 13 and 14 of Part III of Form 10-K, because a definitive proxy statement containing such information will not be filed within 120 days after the end of the fiscal year covered by the Original Filing. This Amendment amends and restates in its entirety Item 9B of Part II, Items 10, 11, 12, 13 and 14 of Part III and Item 15 of Part IV of the Original Filing. Except as expressly set forth herein, this Amendment does not reflect events occurring after the date of the Original Filing or modify or update any of the other disclosures contained therein in any way other than as required to reflect the amendments discussed above. Accordingly, this Amendment should be read in conjunction with the Original Filing and our other filings with the SEC.

i

PART II

Item 9B. Other Information.

On January 25, 2016, the Board of Directors of the Company appointed Susan B. Bayh and Ambassador J. Cofer Black to serve as members of the Board of Directors as Class I Directors.  There are no arrangements or understandings between Ms. Bayh, Ambassador Black or any other person pursuant to which Ms. Bayh or Ambassador Black were appointed as Class I Directors.  There are no transactions to which the Company is a party and in which either Ms. Bayh or Ambassador Black has a material interest that are required to be disclosed under Item 404(a) of Regulation S-K. The new director appointees will be compensated for their respective service on the Board of Directors in accordance with the Company’s director compensation policy and will be reimbursed for reasonable expenses incurred in connection with their respective service on the Board of Directors.

Please see Item 10 under Part III of this Amendment for a brief summary of the business experience of Ms. Bayh and Ambassador Black.

1

PART III

 

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

 

Directors

Our current directors are identified below.

Name

Age

Position

Linda F. Powers6068Class III Director, Chairperson, President and Chief Executive Officer, Chief Financial and PresidentAccounting Officer
J. Cofer Black74Class I Director
Dr. Alton L. Boynton7179Class I Director, Chief Scientific Officer and Secretary
Robert A. Farmer76
Pat Sarma79Class II Director
Dr. Navid Malik4755Class III Director
Jerry Jasinowski73Class II Director
Susan B. Bayh56Class I Director
J. Cofer Black66Class I Director

 

Director Biographies

 

Linda F. Powers.Ms. Powers has served as the Chairperson of our Board of Directors since her appointment on May 17, 2007, and Chief Executive Officer and President since June 8, 2011.2011 and Chief Financial and Accounting Officer since June 8, 2020. Ms. Powers served as a managing director of Toucan Capital Fund II from 2001 to 2010, and Toucan Capital Fund III thereafter.from 2010 to 2018. She also has over 1516 years’ experience in corporate finance and restructurings, mergers and acquisitions, joint ventures and intellectual property licensing. Ms. Powers is a Board memberhas served on the Maryland Stem Cell Research Commission since its establishment in 2006, and served as the Chair for its first two years of operations. Ms. Powers previously served on the boards of the Rosalind Franklin Society, M2GEN (an affiliate of Moffitt Cancer Center), the Chinese Biopharmaceutical Association, and the Rosalind Franklin Society. She was the Chair of the Maryland Stem Cell Research Commission for the first two years of the state’s stem cell funding program, and has served an additional four years on the Commission. Ms. Powers served for several years on a Steering Committee of the National Academy of Sciences evaluating government research funding, and has been appointed to threeseveral Governors’ commissions created to determine how to buildon the respective states’development of biotech and other high-techtechnology industries. For more than six years, Ms. Powers taught an annual internal course at the National Institutes of Health for the bench scientists and technology transfer personnel on the development and commercialization of medical products. Ms. Powers serves on the boards of several private biotechnology companies. Ms. Powers holds a B.A. from Princeton University, where she graduated magna cum laude and Phi Beta Kappa. She also earned a J.D., magna cum laude, from Harvard Law School. We believe Ms. Powers’ background and experience make her well qualified to serve as a Director.

 

J. Cofer Black. Ambassador Black was appointed to the Board of Directors in January 2016. Ambassador Black is an internationally renowned U.S. government leader and expert in cybersecurity, counterterrorism and national security. In addition to serving on company and bank boards, he presently serves as an independent consultant. Between 2009 and 2016, he served as Vice President for Global Operations at Blackbird Raytheon Technologies, a division of Raytheon Company, a NYSE-listed security company. From 2004 until 2008, he provided strategic guidance and business development as Vice Chairman of Blackwater Worldwide and as Chairman of Total Intelligence Solutions. During 2002 – 2005, he was appointed by the President of the United States to serve as the Ambassador, Coordinator for Counterterrorism, reporting directly to the Secretary of State for developing, coordinating and implementing American counterterrorism policy. Prior to his role as Ambassador, he served a 28-year career in the Central Intelligence Agency, reaching Senior Intelligence Service (SIS-4) level as Director, Counterterrorist Center (D/CTC), where he managed 1,300 professional personnel and an annual operational budget of more than one billion dollars. Ambassador Black is experienced representing the United States at the Head of State level, managing media as a diplomatic spokesperson and in public speaking as keynote speaker both as a senior U.S. Government official and business leader. Ambassador Black has received numerous awards and recognitions throughout his career, including the Distinguished Intelligence Medal (the CIA’s highest award for achievement). Ambassador Black received a B.A. in International Affairs from the University of Southern California in 1973 and an M.A. in International Affairs from the University of Southern California in 1974. We believe Ambassador Black’s background and experience in business management and information technology make him well qualified to serve as a Director.


Alton L. Boynton, Ph.D.Dr. Boynton co-founded our Company, has served as our Chief Scientific Officer and a Director since our inception in 1998, was appointed our Chief Operating Officer in August 2001, was appointed President in May 2003, and served as Chief Executive Officer from June 2007 to June 2011. Prior to founding our Company, Dr. Boynton headed the Molecular Oncology research lab at the Pacific Northwest Research Foundation (the original foundation of Bill Hutchinson, from which the Fred Hutchinson Cancer Center was spun off). Dr. Boynton also served as Director of the Department of Molecular Medicine of Northwest Hospital from 1995 to 2003 where he coordinated the establishment of a program centered on carcinogenesis. Prior to joining Northwest Hospital, Dr. Boynton was Associate Director of the Cancer Research Center of Hawaii, The University of Hawaii, where he also held the positions of Director of Molecular Oncology of the Cancer Research Center and Professor of Genetics and Molecular Biology. Dr. Boynton received his Ph.D. in Radiation Biology from the University of Iowa in 1972. We believe Dr. Boynton’s background and experience make him well qualified to serve as a Director.

 

Robert A. FarmerPat Sarma. . Mr. FarmerSarma was appointed to the Board of Directors in December 2009.March 2024. Mr. Farmer servedSarma brings decades of experience as the national treasurer of four presidential campaigns, including those for John Kerry, Bill Clinton, Michael Dukakisa business executive and John Glenn. In these roles he led fundraising of over $800 million. He served under Ron Brown as treasurera venture capital investor. One of the Democratic National Committee,companies he founded and servedbuilt was American Megatrends Inc. (AMI), which developed hardware, software and firmware components of PC-based systems. AMI developed the AMIBIOS firmware program for eightIBM-PC compatibility. The BIOS (Basic Input Output System) is the heart of PC-compatibility and all application programs access the BIOS in reading from or writing to peripheral units such as drives, keyboards, mouse, etc. AMI also developed, among other software, the AMI RAID Controller and Management software that was the fastest performer in the industry during the 1990’s and early 2000’s. Mr. Sarma’s interests in AMI were acquired in 2001, and thereafter he became a venture capital investor in the private equity markets. He was an owner for a number of years as treasurer of the Democratic Governors Association. President Clinton appointedN.J. Devils team in the National Hockey League, and has invested in a diverse range of industries including medical and environmental companies. Mr. Farmer asSarma received a Master’s Degree in Industrial Engineering and Operations Research from Georgia Tech and a Bachelor’s Degree in Mechanical Engineering from the United States Consul General to Bermuda, where he served from 1994 to 1999. Mr. Farmer also had a successful career as an entrepreneur, including building his own publishing company, which he sold in 1983. Mr. Farmer currently serves on the boardsUniversity of directors of International Data Group, Dale Carnegie Associates, Sober Steering Sensors, LLC, Charlesbridge Publishing, and Haute Living. Mr. Farmer is a graduate of Dartmouth College and Harvard Law School.Madras. We believe that Mr. Farmer’sSarma’s background and experience as well as his service on other boards of directors, make him well qualified to serve as a Director.director.

 

Dr. Navid Malik. Dr. Malik was appointed to the Board of Directors in April 2012. Dr. Malik is currently Head of Research and an Executive Director at The Life Sciences Division, a UK Investment Bank (since 2018). From January 2012 to December 2015, Dr. Malik was previously the Head of Life Sciences Research at Cenkos Securities Plc. in the U.K., an institutional stockbroking securities firm. Dr. Malik is currently the Head of Life Sciences Research at Cenkos Securities Plc. in the U.K., an independent specialist institutional securities firm. From September 2011 through January 2012, Dr. Malik was the Head of Life Sciences Research at Sanlam (Merchant Securities), a global financial services firm. Dr. Malik was Partner and Head of Life Sciences at Matrix Investment Banking Division, Matrix Group, a financial services firm in London, from December 2008 through September 2011. Dr. Malik was a Senior Pharmaceuticals and Biotechnology Analyst at Wimmer Financial LLP from September 2008 through December 2008, and was the Senior Life Sciences Analyst at Collins Stewart Plc from January 2005 through September 2008. In 2011, Dr. Malik was awarded two StarMine Awards (awarded each year by Thomson Reuters and the Financial Times): Number One Stock Picker in the European Pharmaceutical Sector, and Number Two Stock Picker in the U.K. and Ireland Healthcare Sector. Dr. Malik holds a Ph.D. in Drug Delivery within Pharmaceutical Sciences, as well as degrees in Biomedical Sciences Research (M.Sc.) and Biochemistry and Physiology (B.Sc., joint honors). Dr. Malik also holds an MBA in finance from the City University Business School, London. We believe that Dr. Malik’s extensive experience in the life sciences fields and investment banking sector make him well qualified to serve as a Director.

 

2

5

 

 

Jerry Jasinowski. Mr. Jasinowski was appointed to the Board of Directors in April 2012. Mr. Jasinowski retired in 2007. Mr. Jasinowski currently serves on the Boards of Procurian and the Washington Tennis and Education Foundation and has held directorships in several other companies since 1990. From 2004 through 2007, Mr. Jasinowski served as the President of the Manufacturing Institute, an organization dedicated to improving and expanding manufacturing in the United States, of which he was a founder. Mr. Jasinowski was also the President and CEO of the National Association of Manufacturers, a trade association with 13,000 corporate members from 1990 to 2004. Mr. Jasinowski holds an A.B. in Economics from Indiana University and an M.A. in Economics from Columbia University. We believe that Mr. Jasinowski’s extensive experience across a wide range of manufacturing, technology, and financial firms, including Fortune 1000 and Fortune 500 companies, make him well qualified to serve as a Director.EXECUTIVE OFFICERS

 

Susan B. Bayh. Ms. Bayh was appointed to

The following table sets forth information regarding the Board of Directors in January 2016. Ms. Bayh brings 25 years of experience related to the pharmaceutical and biotech industries, including in immunotherapies for cancer. Ms. Bayh previously served as in-house counsel for Eli Lilly’s Pharmaceutical Division, and currently holds directorships at the following companies: Emmis Communications, Inc., a NASDAQ-listed radio and media company (1994-present) and Dendreon Corp., a NASDAQ-listed company focusing on prostate cancer (2003-present). Further, Ms. Bayh previously held directorships during the past five years at the following companies: Anthem Inc. (previously known as Wellpoint, Inc.), a NYSE-listed health insurance company (1998-2013); Curis, Inc., a NASDAQ-listed biotech company focusing on oncology (2000-2013); and Dyax, Inc., a NASDAQ-listed biotech company focused on hereditary angioedema (2003-2012). Ms. Bayh currently serves as a member of the Dean’s Council of Indiana University School of Public and Environmental Affairs, and is a guest lecturer on corporate governance issues at the Wharton School at the University of Pennsylvania. From 1994 until 2001, Ms. Bayh served as US Commissioner on behalf of the U.S. State Department to the International Joint Commission between the United States and Canada. Ms. Bayh also served as First Lady of Indiana from 1988-1996 during her husband’s (Evan Bayh) term as Governor of Indiana, and was involved in various philanthropic efforts including the Indiana Literacy Foundation. Ms. Bayh is licensed to practice law in the State of Indiana and the District of Columbia. She received a B.S. from the University of California at Berkeley in 1981 and a J.D. from the University of Southern California Law School in 1984. We believe Ms. Bayh’s background and experience make her well qualified to serve as a Director.

J. Cofer Black. Ambassador Black was appointed to the Board of Directors in January 2016. Ambassador Black is an internationally renowned U.S. government leader and expert in cybersecurity, counterterrorism and national security. Since 2009, he has served as Vice President for Global Operations at Blackbird Raytheon Technologies, a division of Raytheon Company, a NYSE-listed security company. From 2004 until 2008, he provided strategic guidance and business development as Vice Chairman of Blackwater Worldwide and as Chairman of Total Intelligence Solutions. During 2002–2005, he was appointed by the President of the United States to serve as the Ambassador, Coordinator for Counterterrorism, reporting directly to the Secretary of State for developing, coordinating and implementing American counterterrorism policy. Prior to his role as Ambassador, he served a 28-year career in the Central Intelligence Agency, reaching Senior Intelligence Service (SIS-4) level as Director, Counterterrorist Center (D/CTC), where he managed 1,300 professional personnel and an annual operational budget of more than one billion dollars. Ambassador Black is experienced representing the United States at the Head of State level, managing media as a diplomatic spokesperson and in public speaking as keynote speaker both as a senior U.S. Government official and business leader. Ambassador Black has received numerous awards and recognitions throughout his career, including the Distinguished Intelligence Medal (the CIA’s highest award for achievement). Ambassador Black received a B.A. in International Affairs from the University of Southern California in 1973 and a M.A. in International Affairs for the University of Southern California in 1974. We believe Ambassador Black’s background and experience make him well qualified to serve as a Director.

Executive Officers

OurCompany’s current executive officers are identified below.officers.

 

Name Age Position
Linda F. Powers 6068 Class III Director, Chairperson, President and Chief Executive Officer, Chief Financial and PresidentAccounting Officer
Alton L. Boynton, Ph.D. 7179 Class I Director, Chief Scientific Officer and Secretary
Leslie J. Goldman 7179 Senior Vice President, Business DevelopmentGeneral Counsel
Marnix L. Bosch, Ph.D. 5765 Chief Technical Officer

 

Linda F. Powers. Please see “Director Biographies”Director Biographies above.

 

Alton L. Boynton, Ph.D.Please see “Director Biographies”Director Biographies above.

 

Leslie J. Goldmanjoined us in June 2011, and serves as Senior Vice President Business Development in June 2011.and General Counsel. In this capacity, Mr. Goldman has responsibility for legal matters, investor relations and financing activities. Prior to joining us, Mr. Goldman was a partner at the law firm of Skadden, Arps for over 30 years, specializing in a wide array of advanced technologies and their commercialization. Mr. Goldman also serves as an advisor to a number of other technology companies. In addition, for eight years, Mr. Goldman served as Chairman of the Board of a group of TV stations in four mid-size cities across the country. Mr. Goldman received a B.A. from the University of Michigan in 1967 and a J.D. from the University of Michigan in 1970.

 

Marnix L. Bosch, Ph.D. joined us in 2000, and has been servingserves as our Chief Technical Officer for a number of years.Officer. In this capacity, heDr. Bosch plays a key role in the preparation and submission of our regulatory applications, as well as ongoing development of our product lines, and ongoing development and/or acquisition of new technologies. Dr. Bosch led the process of designing the protocols, and managed the successful preparation and submission of our Investigational New Drug (IND) applications for FDA approval to conduct clinical trials for prostate cancer, brain cancer, ovarian cancer and multiple other cancers. He also led the processes for other regulatory submissions in both the U.S. and abroad (including the successful applications for orphan drug status in both the U.S. and Europe for DCVax-L for brain cancer). He spearheaded the development of our manufacturing and quality control processes, and is working with Cognate BioServices, Inc. on next-generation further development of these processes. Prior to joining us in 2000, Dr. Bosch worked at the Dutch National Institutes of Health (RIVM) as head of the Department of Molecular Biology, as well as in academia as a professor of Pathobiology. He has authored more than 40 peer-reviewed research publications in immunology and virology, and is an inventor on several patent applications on dendritic cell product manufacturing.

 

Corporate Governance

6

CODE OF CONDUCT

 

Director IndependenceWe have an established Code of Conduct applicable to all Board members, executive officers, employees and contractors. Our Code of Conduct is posted on our website at www.nwbio.com.

 

CORPORATE GOVERNANCE

Our Board

There are no material changes to the procedures by which security holders may recommend nominees to the Company’s board of Directors has undertaken a review of the independence of our directors and has determined that a majority of the Board consists of members who are currently “independent” as that term is defined within the meaning of Section 5605(a)(2) of the NASDAQ Marketplace Rules. The Board of Directors considers Messrs. Farmer, Malik and Jasinowski, Ambassador Black and Ms. Bayh to be independent.

directors.

 

Audit Committee

 

The Audit Committee has responsibility for recommending the appointment of our independent accountants, supervising our finance function (which includes, among other matters, our investment activities), reviewing our internal accounting control policies and procedures, and providing the Board such additional information and materials as it may deem necessary to make the Board aware of significant financial matters which require the attention of the Board. The Audit Committee discusses the financial statements with management, approves filings made with the SEC and maintains the necessary discussions with the Company’s independent accountants. The Audit Committee acts under a written charter.charter, which is posted on our website at www.nwbio.com/board-committee-charters/.

 

The Audit Committee currently consists of Messrs. Farmer,Dr. Malik and Jasinowski.Mr. Sarma. Our Board of Directors has determined that Mr. Sarma, the Chairman of the Audit Committee, qualifies as an “audit committee financial expert” as defined by the SEC. Our Board has undertaken a reviewdetermined that each member of the independence of our directors and has determined that Messrs. Farmer, Malik and Jasinowski are independentAudit Committee is “independent” within the meaning of Section 5605(a)(2) of the NASDAQ MarketplaceNasdaq Stock Market Rules as well as pursuant to the additional test for independence for audit committee members imposed by SEC regulation and Section 5605(c)(2)(A) of the NASDAQ MarketplaceNasdaq Stock Market Rules. The Audit Committee is established in accordance with Section 3(a)(58)(A) of the Exchange Act.

3

Compensation Committee

The Compensation Committee is responsible for determining the overall compensation levels of our executive officers and administering our equity compensation plans. The Board has adopted a written charter for the Compensation Committee and its current members are Messrs. Farmer, Malik and Jasinowski. The Compensation Committee does not delegate its authority pursuant to its written charter. The Board has determined that all of the members are “independent” under the current listing standards of NASDAQ.

Nominations Committee

The Nominations Committee is responsible for assisting the Board of Directors in, among other things, effecting Board organization, membership and function, including: identifying qualified Board nominees; and effecting the organization, membership and function of Board committees, including composition and recommendation of qualified candidates. The Nominations Committee shall identify and evaluate the qualifications of all candidates for nomination for election as directors. Potential nominees are identified by the Board of Directors based on the criteria, skills and qualifications that have been recognized by the Nominations Committee. While our nomination policy does not prescribe specific diversity standards, the Nominations Committee and its independent members seek to identify nominees that have a variety of perspectives, professional experience, education, difference in viewpoints and skills, and personal qualities that will result in a well-rounded Board of Directors.

The Nominations Committee currently consists of Messrs. Farmer, Malik and Jasinowski. The Board of Directors has determined that all of the members are “independent” under the current listing standards of NASDAQ. The Board of Directors has adopted a written charter setting forth the authority and responsibilities of the Nominations Committee.

Information Regarding Meetings of the Board and Committees

The business of our Company is under the general oversight of our Board, as provided by the laws of Delaware and our bylaws. During the fiscal year ended December 31, 2015, the Board met more than 20 times and also conducted business by written consent. The Audit Committee met more than 4 times. Each person who was a director during 2015 attended at least 75% of the Board meetings. We do not have a formal written policy with respect to Board members’ attendance at our annual meeting of stockholders. Three of our directors attended the 2015 annual meeting.

Code of Business Conduct and Ethics

We have adopted a formal Code of Business Conduct and Ethics applicable to all Board members, executive officers and employees. A copy of our Code of Business Conduct and Ethics will be provided free of charge upon request to Secretary, Northwest Biotherapeutics, Inc., 4800 Montgomery Lane, Suite 800, Bethesda, Maryland, 20814.

Section 16(a) Beneficial Ownership Reporting Compliance

Section 16(a) of the Exchange Act requires our directors, executive officers and persons who own more than 10% of our stock, or Reporting Persons, to file with the SEC initial reports of ownership and changes in ownership of our stock. Reporting Persons are required by SEC regulations to furnish us with copies of all Section 16(a) reports they file. To our knowledge, based solely on our review of the copies of such reports received, we believe that during our fiscal year ended December 31, 2015 all Reporting Persons timely complied with all applicable filing requirements. Cognate BioServices, Inc., an affiliate of the Company, did not timely file certain Form 4 filings in connection with its acquisition or disposition of our securities.

ITEM 11.EXECUTIVE COMPENSATION

 

Compensation Discussion and Analysis

ExecutiveOverview

This Compensation Discussion and Analysis describes the compensation program for the Company’s principal executive and principal financial officer, and our three most highly compensated executive officers other than our principal executive and financial officer who were serving as executive officers as of December 31, 2023. We refer to these individuals as our “named executive officers” or “NEOs.”

For purposes of this executive compensation discussion, the names and positions of our named executive officers for the 2023 fiscal year were:

Linda F. Powers, President and Chief Executive Officer, Chief Financial and Accounting Officer;

Leslie Goldman, Senior Vice President and General Counsel;

Marnix L. Bosch, Ph.D., Chief Technical Officer; and

Alton L. Boynton, Ph.D., Chief Scientific Officer and Secretary.

Philosophy and Objectives

 

Our success is highly dependent on our ability to attract, retain and incentivize executive officers who possess the skills, competencies and passion that are necessary to achieve progress in the Company's clinical programs and progress toward eventual commercialization, as well as to contend with ongoing challenges to the Company's progress. To this end, our compensation program has been developed with the following overarching principles in mind:

the pay of our NEOs should balance incentivizing performance, ensuring retention and building stockholder value and should be linked to the NEO's roles and contributions to the Company's progress.
the pay of our NEOs should retain and incentivize individual NEOs to perform multiple senior executive roles each, at least until such time as the Company's progress and resources enable expansion of the management team.

our executive compensation program should enable us to recruit, develop, motivate and retain top talent. This is especially critical in a rapidly evolving field such as immuno-oncology, which requires highly specialized knowledge and experience and for which the talent pool is highly competitive.

Periodically, management makes recommendations to the Compensation Committee and the Compensation Committee reviews the objectives and components of our executive compensation program to assess whether they continue to meet these essential goals. The Company’sCompensation Committee Chairman also maintains regular contact with the NEOs to ensure that he not only gets a detailed view of the performance and milestones achieved by the NEOs and the Company, but also so that he has the ability to personally assess and make available to the Committee a detailed summary of performance of the NEOs and employees of the Company for the applicable review period.

To establish compensation philosophyparameters for our named executive officers, our Compensation Committee evaluates each element of compensation separately and the total compensation for each named executive officer, as well as the compensation levels at similarly situated companies - other oncology biotech companies who are at a comparable stage of company development as the Company, taking account of the stage of the other companies' clinical programs and whether they have any products approved or on the market. Based on the reviews and analyses to date, our Compensation Committee determined that our process for determining executive compensation is appropriate to assure that the Company’s compensation and benefits policies attract, and to retain and incentivize, the key employees necessary to support the Company’s growth and success, both operationally and strategically, and to motivate the executives to achieve short- and long-term goals with the ultimate objective of creating sustainable improvements in stockholder value. This principle guides the design and administration of compensation and benefits programs for the Company’s Named Executive Officers, othersenior executives, and the general workforce.

is aligned with stockholder interests.

 

Risk Management and Mitigation

4

 

In reviewing our compensation structure in 2023, the Compensation Committee also considered whether our compensation policies and practices could affect our risk profile and whether such compensation policies and practices could potentially encourage excessive risk taking by our employees.

Elements of 2023 Compensation

Our 2023 executive compensation program consisted of one primary element—base salary.

The Company anticipates that bonuses will also be awarded to the NEOs in respect of performance during 2023, since the Company believes that 2023 was a year of exceptional progress, including completion and submission to the UK regulatory authority of the Company's first application for commercial approval of its DCVax®-L immunotherapy, significant progress in the development and optimization of its Flaskworks manufacturing system, approval of a commercial manufacturing license for the Company's Sawston, UK GMP facility, expansion of the Company's intellectual property portfolio, and achievement of other major milestones and progress as described in the Management Discussion and Analysis in the Company's Annual Report on Form 10-K.

In several prior years, the Company has determined annual bonuses on a delayed basis when additional time was needed for adequate review and determination. Also in multiple prior years, even after executive bonuses have been determined, awarded and reported in the Company's filings, the payment of such bonuses has been delayed (in some instances for multiple years) based on resource considerations. For 2023, the review and determination will be conducted on a delayed basis.


Base Salary

 

Base Salary. All full time Named Executive Officers are paid a base salary.salary is the fixed portion of an executive’s annual compensation. Base salaries for our executivesNEOs are established based on the individual’s scope of their responsibilities, professional qualifications, academic backgroundexperience, contributions to the Company's progress, and market factors. The Compensation Committee typically reviews base salaries on an annual basis. The Committee reviews the other elementsbase salary of our CEO in executive session and recommends her base salary to the non-executive members of the executive’s compensation, including equity-based compensation. Base salaries are reviewed at least annually, and may be increased to align salaries with market levels after taking into account the subjective evaluation previously described.

Bonuses. All full time Named Executive Officers are eligibleBoard for bonuses from time to time, on a case by case basis,approval, based on Company and/or individual performance considerations and/or on retention considerations.

Equity Incentive Compensation. We believe that long-term performance is achieved through an ownership culture participated in by our Named Executive Officers through the use of stock-based awards. The Company maintains an incentive compensation plan for such awards. No awards have been granted recently under the plan, but such awards are expected to be made in due course. The Board of Directors does not have a pre-determined formula for deciding the equity awards to be made.

Determination of Compensation

The Company’s executive compensation program for the Named Executive Officers is administered by the Board of Directors’ Compensation Committee. Ascriteria described above, the Compensation Committee consists of three independent directors, all of whom have considerableexperience in executive compensation issues and management development. As also described above, the Compensation Committee operates under a written charter adopted by the Board of Directors.above.

 

The Compensation Committee continuesdoes not use a formulaic approach when setting an executive officer’s base salary. However, taking into account the recommendations of our CEO, the Compensation Committee's assessment includes factors such as the following when determining (or, in the case of the CEO, recommending to examinethe Board) individual base salary levels:

the nature and responsibility of the executive’s position,

where applicable, the executive's performance of multiple roles that would typically be held by separate executives (with separate compensation) at other companies,

competitive considerations for retaining and incentivizing the executive, and

the executive’s expertise, tenure, responsibilities and performance.

Our Compensation Committee held a series of meetings to review NEOs' compensation and refine our compensation philosophy, objectives and strategy throughout the fiscal year.determine 2023 base salaries for NEOs. The Compensation Committee’s guiding principleCommittee considered information about pay practices at a substantial number of other oncology biotech companies at a similar stage of development as Northwest Biotherapeutics (late stage clinical trials, with no products approved or on the market yet), which was gathered by management and provided to the Committee. The Committee considered each NEO's roles (including performance of multiple roles) and contributions as well as the Company's strong progress. The Committee also took account of the NEOs' compensation history, including that base salaries have been the same for three years, in 2020, 2021 and 2022, and that payment of performance based bonuses has tended to be substantially delayed. The Committee also considered management's recommendations for increases in 2023 base salaries. The Committee conducted these assessments internally and did not engage an external compensation consultant. The Committee deliberated without management present.

In light of the above considerations, the Committee determined that raises in the NEO base salaries recommended by management were appropriate for 2023, as set forth in the Summary Compensation Table below. The Committee recommended that the Board approve these raises in base salaries. The Committee noted that bonuses would be addressed separately at another time.

The Board met and considered the factors described above, without management present, and approved the raises in base salaries recommended by the Compensation Committee for Ms. Powers, Mr. Goldman, Dr. Bosch and Dr. Boynton.

Annual Bonus Awards

The Company anticipates making performance based bonus awards in respect of performance during 2023, based on the exceptional milestones and Company progress achieved during the year, as described above, but has not yet determined the bonuses.

Our NEOs are eligible to receive an annual bonus taking into account their individual performance and the performance of the Company. The Company determines Annual Bonus Awards based upon progress achieved in the Company’s programs (including clinical development, manufacturing, intellectual property and finances) and progress toward potential eventual commercialization, as well as the individual’s roles and contributions toward the progress.

Equity Awards

The Company did not make any equity compensation awards to the NEOs in 2023. The Company has made no equity awards in the four years since option awards were last granted in 2020. Overall, the Company has only made equity awards to its key executive officers twice in the 13 years since 2011 (once in 2017 or 2018*, and once in 2020), except for Dr. Boynton, the Company's Chief Scientific Officer, to whom the Company has only made equity awards three times in these 13 years (2017, 2018 and 2020).

However, the equity pool reserved for employees and directors established under the Company's Equity Compensation Plan remains in place. The equity pool includes 20% of the Company's securities, some of which have been issued to employees and directors and some of which remain available in the pool.

Additional information regarding the stock options granted to NEOs four years ago, in 2020, is set forth below in the “Summary Compensation Table” and the “Outstanding Equity Awards at 2023 Fiscal-Year End” table.

Other Compensation Plans

401(k) Plan. The NEOs are eligible to participate in employee benefit plans and programs, including long-term disability, to the same extent as the Company’s other full-time employees, subject to the terms and eligibility requirements of those plans. The NEOs also participate in our 401(k) plan, subject to limits imposed by the Internal Revenue Code, to the same extent as the Company’s other full-time employees.

Other Benefits. We do not maintain any defined benefit pension plans or any nonqualified deferred compensation plans.

Limited Perquisites. Perquisites or other personal benefits are not a significant component of the compensation to our NEOs. We provide limited perquisites to our NEOs, such as coverage of phone and internet costs.

* Dr. Bosch received an option award in 2017 but not 2018. Ms. Powers and Mr. Goldman received an option award in 2018 but not 2017. Only Dr. Boynton, the Company's Chief Scientific Officer, received an option award in both 2017 and 2018.


Employment Agreements. The Company entered into employment agreements with each of Ms. Powers, Mr. Goldman Dr. Bosch and Dr. Boynton in 2011. The 2011 agreements have expired. The Company entered into a new employment agreement with Dr. Bosch, which is currently in effect. The Company plans to enter into new employment agreements with Ms. Powers, Mr. Goldman and Dr. Boynton in due course.

Process for Setting Executive Compensation

Compensation Committee Review

Our Compensation Committee reviews the elements of our NEOs’ total compensation during the year, to evaluate whether each element is providing appropriate compensation to retain and incentivize the executive, and to be competitive. In making compensation decisions, the Committee relies on its own judgment after considering similarly situated companies, and also considers the factors listed above in connection with base salary determinations and the following factors:

the executive's scope of responsibilities, including whether the executive is performing multiple senior executive roles;

the executive’s leadership, management and technical expertise, growth potential, and position in our reporting structure;

overall Company and individual performance;

retention needs and competitive considerations; and

the recommendations of our CEO (except with respect to her own compensation).

Each year, the Compensation Committee expects to evaluate all elements of executive officer compensation, after reviewing the prior year’s results and the achievement of Company operational and financial objectives. The purpose of this annual evaluation is to assure thatdetermine whether any changes in an officer’s compensation may be appropriate. The CEO does not participate in the Company’s compensation and benefits policies attract and retainCommittee’s deliberations regarding her own compensation. At the key employees necessary to supportCommittee’s request, the Company’s growth and success, both operationally and strategically, and to motivate the executives to achieve short- and long-term goalsCEO may review with the ultimate objectiveCommittee the performance of creating sustainable improvements in stockholder value. This principle guides the designother executive officers. Our Compensation Committee gives substantial weight to the CEO’s evaluations and administration of compensationrecommendations because she is particularly able to assess the other executive officers’ performance and benefits programscontributions.

Independent Compensation Consultant

The evaluations and analyses for the 2023 base salaries for the Company’s Named Executive Officers, other executivesNEOs were done internally, and the general workforce.not by a compensation consultant.  

 

Director Compensation Committee Report

The compensation committee has reviewed and discussed the compensation discussion and analysis included in this Annual Report on Form 10-K/A with management and, based on such review and discussions, the compensation committee recommended to our board of directors that the compensation discussion and analysis be included in the Company’s Annual Report on Form 10-K/A for filing with the SEC.

The foregoing report has been furnished by the Compensation Committee.
Dr. Navid Malik (Chairperson)
Pat Sarma


Summary Compensation Table

 

The following table sets forth certain information concerning compensation paid to or accrued to our non-executive directors for the year ended December 31, 2015.

Name Year  

Fees Earned or

Paid in Cash

($)

  

All Other

Compensation

($)

  

Total

($)

 
Robert A. Farmer  2015  $150,000  $-  $150,000 
Dr. Navid Malik  2015  $150,000  $-  $150,000 
Jerry Jasinowski  2015  $150,000  $-  $150,000 

Executive Compensation

Summary Compensation Table

The following table sets forth certain information concerning compensation paid or accrued to our executive officers, referred to as our Named Executive Officers, during the years ended December 31, 2015, 20142023, 2022 and 2013.

2021.

 

Name and Principal Position Year 

Salary

($)

  

Bonus

(S)

  

Option Awards

($)

  

Total

($)

 
               
Linda F. Powers 2015 $500,000  $-  $-  $500,000 
Chairperson, President 2014 $500,000  $-  $-  $500,000 
& Chief Executive Officer 2013 $360,000  $-  $-  $360,000 
                   
Alton L. Boynton, Ph.D. 2015 $325,000  $-  $-  $325,000 
Chief Scientific Officer and 2014 $325,000  $-  $-  $325,000 
Secretary 2013 $295,685  $-  $-  $295,685 
                   
Leslie Goldman 2015 $375,000  $-  $-  $375,000 
Senior Vice President, 2014 $375,000  $50,000  $-  $425,000 
Business Development 2013 $348,000  $-  $-  $348,000 
                   
Marnix L. Bosch, Ph.D. 2015 $375,000  $-  $-  $375,000 
Chief Technical Officer 2014 $375,000  $50,000  $-  $425,000 
  2013 $325,181  $-  $-  $325,181 
Name and Principal Position Year  Salary
($)
  Bonus
($)(1)
  Option
Awards
  Total
($)
 
Linda F. Powers (2) 2023   925,000         925,000 
Chairperson, President and Chief Executive Officer, Chief Financial and Accounting Officer 2022
2021
   700,000
700,000
   400,000
300,000
   
   1,100,000
1,000,000
 
              
Leslie Goldman (3) 2023   725,000         725,000 
Senior Vice President, General Counsel 2022   525,000   300,000      825,000 
  2021   525,000   200,000      725,000 
                    
Marnix L. Bosch, Ph.D.(4) 2023   453,600         453,600 
Chief Technical Officer 2022   397,500   200,000      597,500 
  2021   442,500   125,000      567,500 
                    
Alton L. Boynton, Ph.D. (5) 2023   375,000         375,000 
Chief Scientific Officer and Secretary 2022   350,000   100,000      450,000 
  2021   350,000   75,000      425,000 

 

(1)5The Company plans to award performance bonuses for executives for 2023, in light of the major milestones met and progress made in 2023, but the bonuses have not yet been determined.

Grants of Plan-Based Awards

 

(2)The bonuses in 2022 and 2021 were for Ms. Powers’ performance during 2022 and 2021, respectively, which were approved in 2023 and 2022, respectively. The 2021 bonus was paid in March 2023. The 2022 bonus was paid in December 2023.

(3)The bonuses in 2022 and 2021 were for Mr. Goldman’s performance during 2022 and 2021, respectively, which were approved in 2023 and 2022, respectively. The 2021 bonus was paid in March 2023. The 2022 bonus was partially paid as of December 31, 2023.

(4)Dr. Bosch was relocated to our subsidiary in Netherlands effective August 1, 2019. His current annual salary is 420,000 euros, which is equivalent to approximately $454,000. Dr. Bosch’s compensation is paid in Euros and therefore varies based on the exchange rate. The compensation amounts paid to Dr. Bosch presented in the table above are determined by multiplying the amount of euros paid by the average exchange rate of $1.08 per euro for fiscal 2023, of $1.06 per euro for fiscal 2022, and of $1.18 per euro for fiscal 2021.

The Company has an equity compensation planbonuses in 2022 and 2021 were for employees, directorsDr. Bosch’s performance during 2022 and others, the Amended2021, respectively, which were approved in 2023 and Restated 2007 Stock Plan, which2022, respectively. The 2021 bonus was approved by shareholders at the Company’s 2013 Annual Meeting of Stockholders, and amended and restated a prior equity compensation plan.paid in March 2023. The Company2022 bonus has not issued any recent awards under the amended plan, but such awards are expected to be made in due course.

been paid.

 

(5)The bonuses in 2022 and 2021 were for Dr. Boynton’s performance during 2022 and 2021, respectively, which were approved in 2023 and 2022, respectively. The 2021 bonus was paid in March 2023. The 2022 bonus has not been paid.


Outstanding Equity Awards at Fiscal Year-End

 

The following table shows outstanding stock option awards classified as exercisable and un-exercisable as of December 31, 2015.2023:

 

  Option Awards  Stock Awards 
Name Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
  Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
  Equity
Incentive
Plan
Awards:
Number of
Securities
Underlying
Unexercised
Unearned
Options (#)
  Option
Exercise
Price
($)
  Option
Expiration
Date
 Number
of
Shares
or
Units
of
Stock
That
Have
Not
Vested
(#)
  Market
Value
of
Shares
or
Units
of
Stock
That
Have
Not
Vested
($)
  Equity
Incentive
Plan
Awards:
Number
of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested
(#)
  Equity
Incentive
Plan
Awards:
Market
or Payout
Value of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested
($)
 
Linda F. Powers  592,500(1)  296,250      10.56  6/21/2018            
Chief Executive Officer and President                                  
                                   
Alton Boynton  93,750(2)  55,000      10.56  6/21/2018            
Chief Scientific Officer and Secretary  126(5)        21.60  2/18/2016            
   89,428(6)        8.80  8/20/2022            
                                   
Leslie Goldman  93,535(3)  46,875      10.56  6/21/2018            
Senior Vice President, Business Development                                  
                                   
Marnix Bosch  93,846(4)  73,750      10.56  6/21/2018            
Chief Technical Officer  209(7)        21.60  2/18/2016            
   338(7)        28.80  12/1/2016            
   31,770(8)  21,355      11.20  6/23/2022            
   15,625(9)        8.80  8/20/2022            
Name Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable (1)
  Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
  Option
Exercise
Price
($)
  Option
Expiration
Date
 
Linda F. Powers  39,200,000(2)   -  $0.23   5/28/2028 

Chairperson, President and Chief Executive Officer, Chief Financial and Accounting Officer

  10,770,429(3)         -  $0.35   7/2/2030 
  32,558,724(3)   -  $0.35   12/1/2030 
  11,789,879(4)   -  $0.55   9/2/2030 
                 
Leslie J. Goldman  24,500,000(5)   -  $0.23   5/28/2028 
Senior Vice President, General Counsel  6,731,518(6)   -  $0.35   7/2/2030 
   21,822,937(6)   -  $0.35   12/1/2030 
   5,894,939(7)   -  $0.55   9/2/2030 
                 
Marnix L. Bosch, Ph.D.  7,740,182(8)   -  $0.25   6/13/2027 
Chief Technical Officer  10,798,729(9)   -  $0.35   7/2/2030 
   16,630,726(10)   -  $0.35   12/1/2030 
                 
Alton L. Boynton, Ph.D.  2,967,065(11)   -  $0.23   8/31/2028 
Chief Scientific Officer and Secretary  3,096,498(12)   -  $0.35   7/2/2030 
   15,697,693(13)   -  $0.35   12/1/2030 

 

(1)In conjunctionMs. Powers and Mr. Goldman are subject to a voluntary blocking agreement under which they cannot exercise any options, warrants or other derivative securities unless they provide the Company at least 61 days’ advance notice.

(2)On May 28, 2018, we granted 39,200,000 stock options to Ms. Powers for service during part of 2018 and a number of preceding years. The options are exercisable at a price of $0.23 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements in 2021, Ms. Powers entered into a voluntary blocking agreement on an ongoing rolling basis with the employment agreementCompany under which Ms. Powers cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Ms. Powers provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(3)On July 2, 2020, we granted 10,770,429 stock options to Ms. Powers for service during several years. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021 Ms. Powers entered into between us anda voluntary blocking agreement with the Company under which Ms. Powers on June 8, 2011,cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Ms. Powers provides the Company at least 61 days’ advance notice. As a result, such options, warrants and in recognitionother derivative securities are not considered “beneficially owned” within the meaning of Ms. Powers’ service to our Company while servingSection 13(d) of the Securities Exchange Act of 1934, as Chair during the preceding four years,amended.


On July 2, 2020, we granted 32,558,724 stock options to Ms. Powers for service during several years. These options were subject to certain vesting requirements which have been fulfilled. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021, Ms. Powers entered into a voluntary blocking agreement on an ongoing rolling basis with the Company under which Ms. Powers cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Ms. Powers provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(4)On September 2, 2020, we granted 11,789,879 stock options to Ms. Powers for service during several years. The options are exercisable at a price of $0.55 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021, Ms. Powers entered into a voluntary blocking agreement on an optionongoing rolling basis with the Company under which Ms. Powers cannot exercise or convert any options, warrants or other derivative securities, as applicable, to purchase 870,637acquire shares of ourthe Company’s common stock, with an exerciseunless Ms. Powers provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(5)On May 28, 2018, we granted 24,500,000 stock options to Mr. Goldman for service during part of 2018 and a number of preceding years. The options are exercisable at a price of $10.56$0.23 per share. One-thirdshare, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021, Mr. Goldman entered into a voluntary blocking agreement on an ongoing rolling basis with the Company under which Mr. Goldman cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Mr. Goldman provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(6)On July 2, 2020, we granted 6,731,518 stock options to Mr. Goldman for service during several years. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021 Mr. Goldman entered into a voluntary blocking agreement on an ongoing rolling basis with the Company under which Mr. Goldman cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Mr. Goldman provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.
On July 2, 2020, we granted 21,822,937 stock options to Mr. Goldman for service during several years. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021 Mr. Goldman entered into a voluntary blocking agreement on an ongoing rolling basis with the Company under which Mr. Goldman cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Mr. Goldman provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

On January 14, 2021, Mr. Goldman assigned 20,000,000 options that were granted on July 2, 2020 to The Goldman NWBIO GRAT Trust for no consideration. On April 28, 2022, Sue Goldman, Trustee of The Goldman NWBIO GRAT Trust transferred 12,709,287 options to Mr. Goldman in satisfaction of the first annuity amount due to Mr. Goldman. As of December 31, 2023, 7,290,713 options were remaining in The Goldman NWBIO GRAT Trust.


(7)On September 2, 2020, we granted 5,894,939 stock options to Mr. Goldman for service during several years. The options are exercisable at a price of $0.55 per share, and have a 10-year exercise period. Following entry into previous securities suspension agreements, in 2021 Mr. Goldman entered into a voluntary blocking agreement on an ongoing rolling basis with the Company under which Mr. Goldman cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, unless Mr. Goldman provides the Company at least 61 days’ advance notice. As a result, such derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(8)On June 13, 2017, we awarded 7,940,182 options to Dr. Bosch under the 2007 Stock Plan for service during several years. The options are exercisable at a price of $0.25 per share, and had a 5-year exercise period. On January 14, 2018, we extended the exercise period of the options from 5-year to 10-year. In 2021, Dr. Bosch entered into a securities suspension agreement with the Company that (i) suspended the exercisability of the vested options and (ii) made no changes to the other terms of such securities. The suspension continued on a monthly basis since then, with respect to 20,429,456 options, until it expired on January 12, 2023. Dr. Bosch received no consideration for entry into such arrangement.

On March 29, 2023, Dr. Bosch cashless exercised 200,000 options.

(9)On July 2, 2020, we granted 10,798,729 stock options to Dr. Bosch for service during several years. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. These options were fully vested upon grant. Dr. Bosch entered into a securities suspension agreement with the Company that (i) suspended the exercisability of the vested options and (ii) made no changes to the other terms of such securities. The suspension agreement expired on January 12, 2023. Dr. Bosch received no consideration for entry into such arrangement.

(10)On July 2, 2020, we granted 16,630,726 stock options to Dr. Bosch for service during several years. The options are exercisable at a price of $0.35 per share, and have a 10-year exercise period. Dr. Bosch entered into a securities suspension agreement with the Company that (i) suspended the exercisability of 13,165,992 of the vested options and (ii) made no changes to the other terms of such securities. The suspension agreement expired on January 12, 2023. Dr. Bosch received no consideration for entry into such arrangement.

(11)On August 31, 2018, we granted 2,967,065 stock options to Dr. Boynton for service during several years. The options are exercisable at a price of  $0.23 per share, and have a 10-year exercise period. 50% of the options vested on the grant date, and upon vesting became subject to50% vested over a lock-up which extended to the earlier of 18 months or our reaching the primary endpoint of our GBM brain cancer clinical trial. One-third of the options vested24-month period in equal monthly portions overinstallments thereafter. Dr. Boynton entered into a securities suspension agreement with the termCompany that (i) suspended the exercisability of the employment agreement. The remaining one-third will vest in portions tied to material milestones in multiple programs, ifvested options and (ii) made no changes to the extent those milestonesother terms of such securities. The suspension agreement expired on January 12, 2023. Dr. Boynton received no consideration for entry into such arrangement.

(12)On July 2, 2020, we granted 3,096,498 stock options to Dr. Boynton for service during 2018, 2019 and 2020. The options are achieved, or may vest in the Board’s discretion.
 (2)In conjunctionexercisable at a price of $0.35 per share, and have a 10-year exercise period. These options were fully vested upon grant. Dr. Boynton entered into a securities suspension agreement with the employmentCompany that (i) suspended the exercisability of the vested options and (ii) made no changes to the other terms of such securities. The suspension agreement entered into between us andexpired on January 12, 2023. Dr. Boynton on June 8, 2011,received no consideration for entry into such arrangement.

On April 4, 2023, Dr. Boynton assigned all 3,096,498 of these options to his relatives for no consideration.

(13)On July 2, 2020, we issuedgranted 15,697,693 stock options to Dr. Boynton an option to purchase 145,162 shares of our stock with an exercisefor service during 2018, 2019 and 2020. The options are exercisable at a price of $10.56$0.35 per share. 86,035share, and have a 10-year exercise period. 50% of these options vested on the grant date. 7,500 options vested in equal monthly portions over the term of the employment agreement. The remaining 51,627 options will vest in portions tied to material milestones in multiple programs, if and to the extent those milestones are achieved, or may vest in the Board’s discretion.
 (3)In conjunction with the employment agreement entered into between us and Mr. Goldman on June 8, 2011, we issued Mr. Goldman an option to purchase 137,750 shares of our stock with an exercise price of $10.56 per share. One-third of the optionswere vested on the grant date, with the remainder vesting in monthly installments over one year. Dr. Boynton entered into a securities suspension agreement with the Company that (i) suspended the exercisability of the vested options and upon vesting became subject to a lock-up which extended(ii) made no changes to the earlierother terms of 18 months or our reachingsuch securities. The suspension agreement expired on January 12, 2023. Dr. Boynton received no consideration for entry into such arrangement.

On July 27, 2022, Dr. Boynton assigned 3,000,000 options to his relatives for no consideration. On December 6, 2022, Dr. Boynton assigned 9,000,000 options to his relatives for no consideration. On April 4, 2023, Dr. Boynton assigned the remaining 3,697,693 options to his relatives for no consideration.


Option Exercises and Stock Vested

The following table shows stock option awards exercised by our Named Executive Officers during the year ended December 31, 2023. No Named Executive Officers vested in any stock awards.

   Option Awards 
Name  Gross Number of Shares
Acquired on Exercise (#)
   Value Realized on
Exercise ($)
 
Linda F. Powers  -   - 
         
Leslie J. Goldman  -   - 
         
Marnix L. Bosch, Ph.D.  200,000  $74,000(1) 
         
Alton L. Boynton, Ph.D.  -   - 

(1)The value realized upon the primary endpointexercise of our GBM brain cancer clinical trial. One-third vested in equal monthly portions overa stock option is calculated by multiplying (i) the termnumber of the employment agreement. The remaining one-third will vest in portions tied to material milestones in multiple programs, if and to the extent those milestones are achieved, or may vest in the Board’s discretion.
 (4)In conjunction with the employment agreement entered into between us and Dr. Bosch on June 8, 2011, we issued Dr. Bosch an option to purchase 145,473 shares of our common stock with anto which the exercise of the option related, by (ii) the difference between the per-share closing price of our common stock on the date the stock option was exercised and the per-share exercise price of $10.56 per share. 51,971 options vested on the grant date. 7,500 options vested in equal monthly portions overoptions. Represents the term of the employment agreement. The remaining 51,627 options will vest in portions tiedgross value realized prior to material milestones in multiple programs, if and to the extent those milestones are achieved, or may vest in the Board’s discretion.
 (5)These options were granted under the 1999 Plan, the 2001 Plan and under Dr. Boynton’s previous employment agreement. Each of these option grants vests over a four-year period, subject to acceleration in the case of certain events. One-fourth of each option grant vests on the first anniversary of the grant date and the remaining three-fourths of each grant vests in equal monthly installments over the remaining three year vesting period.
 (6)This option was granted under the 2007 Stock Option Plan. The options were granted August 21, 2009 and vested over a one year period and are exercisable over a 10 year period from issuance at a price of $8.80 per share.
 (7)These options were granted under the 1999 Plan and the 2001 Plan. Each of these option grants vested over a four-year period. One-fourth of each option grant vested on the first anniversary of the grant date and the remaining three-fourths of each grant vested in equal monthly installments over the remaining three year vesting period.
 (8)These options were granted under the 2007 Stock Option Plan. 1,250 options vested each month until May 31, 2013.  In addition, 6,250 options vest upon each of Swiss Approval, full Enrollment in Phase II Glioblastoma Multiforme clinical study and FDA approval of NDA.
 (9)This option was granted under the 2007 Stock Option Plan. This option grant vested over the balance of 2009 with 7,813 vesting on the grant date and the remainder vesting on December 31, 2009.any applicable tax withholding.

 

6

Pension BenefitsPotential Payments on Termination or Change in Control

 

Our Named Executive Officers received no benefits in fiscal 2015 from the Company under defined pension or defined contribution plans.

Non-Qualified Deferred Compensation

Our Named Executive Officers received no benefits in fiscal 2015 from the Company under non-qualified deferred compensation plans.

Employment Agreements

The Company entereddoes not currently have any arrangements that would trigger payments upon termination of a NEO or upon a change in control of the Company. However, the Company plans to enter into employment agreements with its Named Executive OfficersMs. Powers, Mr. Goldman and Dr. Boynton in 2011. Those agreements have expireddue course, which may contain such arrangements.

CEO Pay Ratio Disclosure

We are providing the following information about the relationship of the annual total compensation of our employees and the Company intendsannual total compensation of our CEO. Based on the information for fiscal year 2023, we reasonably estimate that the ratio of our CEO’s annual total compensation to enter into new employment agreementsthe annual total compensation of our median employee was 6.4:1. Our pay ratio estimate has been calculated in a manner consistent with its executives.

Item 402(u) of Regulation S-K using the data and assumptions summarized below.

 

We identified our median compensation employee by examining total compensation paid for fiscal year 2023 to all individuals, excluding Ms. Powers, who were employed by us on December 31, 2023, the last day of our fiscal year, based on payroll records. No assumptions, adjustments or estimates were made in respect of total compensation, except that we annualized the compensation of any employee that was not employed with us for all of fiscal year 2023. We excluded independent contractors who are engaged full time by us. We also excluded independent contractors retained on an as-needed basis, whose compensation is determined by an unaffiliated third party, and who are therefore are not considered our employees for purposes of the pay ratio calculation.

Once we identified our median employee, we calculated such employee’s annual total compensation for 2023 in accordance with the requirements of Item 402(c)(2)(x) of Regulation S-K, resulting in that employee’s annual total compensation of $145,000. The median employee’s annual total compensation includes annualized base salary, annualized bonus during the fiscal year ended December 31, 2023.


With respect to the CEO, we used the amount reported as total compensation in the Summary Compensation Table. Any estimates and assumptions used to calculate total annual compensation are described in footnotes to the Summary Compensation Table.

Compensation Committee Interlocks and Insider Participation

None of our officers currently serves, or in the past year has served, as a member of the compensation committee of any entity that has one or more officers serving on our board of directors.

DIRECTOR COMPENSATION

The following table sets forth certain information concerning compensation paid or accrued to our non-executive directors during the year ended December 31, 2023.

Name(2)

 Year  Fees
Earned or
Paid in Cash ($)
  Option
Awards($)
  Total
($)
 
Dr. Navid Malik  2023   150,000      150,000 
                 
Jerry Jasinowski  2023   150,000      150,000 
                 
J. Cofer Black  2023   150,000      150,000 

The non-executive independent directors were compensated on a monthly basis $12,500 ($150,000 annually) for their consistent availability on short notice, participation in the frequent meetings of the board of directors, leadership of at least one board committee, participation on multiple committees of the Board, commitment to corporate governance initiatives, and frequent consultations with management on operational matters. The Company owed Mr. Jasinowski $275,000 as of December 31, 2023.

Ms. Powers and Dr. Boynton are executives of the Company and do not receive separate compensation for their services as a director.

ITEM 12.SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERSMATTERS-EQUITY COMPENSATION PLAN INFORMATION

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

 

The following table presents information regarding the beneficial ownership of our common stock as of April 29, 2016,1, 2024 by:

 

·each person, or group of affiliated persons, who is known by us to beneficially own beneficiallymore than 5% or more of any class of our equity securities;

·our directors and nominees for director;

·each of our named executive officers,Named Executive Officers, as defined in Item 402(a)(3) of Regulation S-K; and

·our directors and executive officers as a group.

 

In order to determineShares of Common Stock beneficially owned and the respective percentages of beneficial ownership of Common Stock assume the exercise of all options, warrants and other securities convertible into common stock beneficially owned by a givensuch person as set forth in the table below, the fully diluted shares,or entity currently exercisable or exercisable within 60 days of April 1, 2024, and we assume no exercise of any options, warrants and warrants heldother securities by theany other person are deemed held by that person and counted in addition to their issued and outstanding shares. However, for all other persons, only the actual issued and outstanding shares they hold are counted.or entity. Shares issuable pursuant to the exercise of stock options and warrants exercisable withinon or prior to the date 60 days ofafter April 29, 2016,1, 2024 are deemed outstanding and held by the holder of such options or warrants in addition to all issued and outstanding shares held by such person, for computing the percentage of outstanding common stock beneficially owned by such person, but are not deemed outstanding for computing the percentage of outstanding common stock beneficially owned by any other person.

 


Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the persons and the entities named in the table have sole voting and investment power with respect to all shares of common stock that they beneficially own, subject to applicable community property laws, if any. The table below is based upon the information supplied by our executive officers, directors and principal stockholderstransfer agent, Computershare Trust Company, N.A., the Company’s records and from Schedules 13D and 13G filed with the SEC.

 

Except as otherwise noted, the address of the individuals in the following table is c/o Northwest Biotherapeutics, Inc., 4800 Montgomery Lane, Suite 800, Bethesda, MD 20814.

 

Name and Address of Beneficial Owner 

Number of Shares

Beneficially Owned

  Percentage(1) 
       
Officers and Directors        
Alton L. Boynton, Ph.D.(2)  195,367   *%
Marnix L. Bosch, Ph.D., M.B.A.(3)  151,381   *%
Linda F. Powers(4)  50,129,904   42.10%
Robert A. Farmer(5)  174,139   *%
Leslie Goldman(6)  504,285   *%
Dr. Navid Malik  10,000   *%
Jerry Jasinowski(7)  134,573   *%
All executive officers and directors as a group (7 persons)  51,299,649   42.81%
         
5% Security Holders        
         

Cognate BioServices, Inc.(8)

4600 East Shelby Drive,

Suite 108, Memphis, TN

  40,640,966   35.59%
         

Woodford Investment Management LLP(9)

9400 Garsington Road

Oxford OX4 2NH, UK

  25,915,937   25.47%
Name of Beneficial Owner Number of Shares Beneficially Owned  

Percentage (1)

 
Directors and Officers:        
Alton L. Boynton, Ph.D.  2,979,254   *%
Marnix L. Bosch, Ph.D., M.B.A.  35,298,794   2.9%
Linda F. Powers(2)  29,411,759   2.5%
Leslie J. Goldman(3)  172,742   *%
Dr. Navid Malik  24,007,288   2.0%
Pat Sarma  12,535,165   1.0%
J. Cofer Black  6,484,433   *%
All executive officers and directors as a group (seven persons)  110,889,435   8.8%

 

7

* Lees than 1%

 

*Less than 1%.
(1)

Percentage represents beneficial ownership percentage of common stock calculated in accordance with SEC rules and does not equate to voting percentages. Based upon 101,740,4401,195,357,817 shares of common stockCommon Stock issued and outstanding as of April 29, 2016.1, 2024. Beneficial ownership is determined in accordance with the rules of the SEC. In computing the number of shares of common stock beneficially owned and the percentage of ownership of such person, we deemed to be outstanding all shares of Common Stock subject to options and warrants currently exercisable or convertible, or exercisable or convertible within 60 days of April 1, 2024, and we also deemed no shares of Common Stock to be outstanding pursuant to warrants or options held by any other person. However, we did not deem such shares outstanding for the purpose of computing the percentage ownership of any other person.

(2)Consists of (i) 12,189 shares held by Dr. Boynton and (ii) 183,178 shares of common stock underlying options that are currently exercisable.
(3)Consists of (i) 9,802 shares held by Dr. Bosch and (ii) 141,579 shares of common stock underlying options that are currently exercisable.
(4)Consists of (i) 1,572,200 shares held by Ms. Powers; (ii) 592,500 shares of common stock underlying currently exercisable options held by Ms. Powers; (iii) 804,14529,411,759 shares of common stock held by Toucan Capital Fund III, L.P.; (iv) 1.732,246Ms. Powers. Ms. Powers also holds 56,992,773 warrants (the majority acquired from a third party and the rest acquired in past years, as previously reported, from the Company in connection with loans by Ms. Powers to the Company when such loans were needed to help enable the Company to survive). Ms. Powers holds 39,200,000 options awarded in 2018 for service during part of that year and a number of preceding years, and 55,119,032 options awarded in 2020 for service during several years. In 2021, Ms. Powers entered into a voluntary blocking agreement with the Company pursuant to which Ms. Powers cannot exercise or convert any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, underlying currently exercisableunless Ms. Powers provides the Company at least 61 calendar days’ advance notice. As a result, such options, warrants held by Toucan Capital; (v) 2,211,784and other derivative securities are not considered “beneficially owned” within the meaning of Section 13(d) of the Securities Exchange Act of 1934, as amended.

(3)Consists of 172,742 shares of common stock held by Toucan Partners, LLC; (vi) 1,505,739 shares of common stock underlying currently exercisableMr. Goldman. Mr. Goldman also holds 643,043 warrants held by Toucan Partners; (vii) 12,645,996 shares of common stock underlying warrants held by Cognate Bioservices, Inc.; and (viii) 28,200,732 shares of common stock held by Cognate Bioservices, Inc. Ms. Powers has voting and dispositive power overacquired in past years, as previously reported, from the securities owned by the Toucan entities and Cognate Bioservices, Inc.
(5)Consists of (i) 135,417 shares held by Mr. Farmer and (ii) 38,722 shares of common stock underlying currently exercisable warrants.
(6)Consists of (i) 172,742 shares heldCompany in connection with loans by Mr. Goldman (ii) 238,008to the Company when such loans were needed to help the Company to survive. Mr. Goldman holds 24,500,000 options awarded in 2018 for service during part of that year and a number of preceding years, and 34,449,394 options awarded in 2020 for service during several years. In 2021, Mr. Goldman entered into a voluntary blocking agreement with the Company under which Mr. Goldman cannot exercise or convert of any options, warrants or other derivative securities, as applicable, to acquire shares of the Company’s common stock, underlying currently exercisableunless Mr. Goldman provides the Company at least 61 calendar days’ advance notice. As a result, such options, warrants and (iii) 93,535 sharesother derivative securities are not considered “beneficially owned” within the meaning of common stock underlying currently exercisable options.Section 13(d) of the Securities Exchange Act of 1934, as amended.
(7)Consists of (i) 79,317 shares held by Mr. Jasinowski and (ii) 55,256 shares of common stock underlying currently exercisable warrants.
(8)Consists of (i) 28,200,732 shares of common stock and (ii) 12,440,234 shares of common stock underlying currently exercisable warrants. Linda Powers holds the voting and dispositive power over the shares held by Cognate BioServices, Inc.
(9)Upon information and belief, Neil Woodford holds the voting and dispositive power over the shares held by Woodford Investment Management LLP


EQUITY COMPENSATION PLAN INFORMATION

On May 29, 2020, the Board of Directors of the Company approved a new equity compensation plan (the “Plan”). The Company’s prior plan was adopted in 2007, was updated in amended and restated plans that were approved by shareholders in 2012 and 2013, and expired in 2017 (the “Prior Plan”).

The Plan is substantially similar to the Prior Plan. The Plan has a 10-year life, and allows for awards to employees, directors and consultants of the Company, as did the Prior Plan. The Plan allows for any type of equity security to be awarded, as did the Prior Plan. The awards and their terms (including vesting) will be determined by the Board and applicable Committees, as was the case under the Prior Plan. The Plan establishes a pool of potential equity compensation equal to twenty percent of the outstanding securities of the Company, which is on an evergreen basis as under the Prior Plan.

On February 25, 2022, the Company amended its existing Equity Compensation Plan, which was adopted in 2020 as previously reported.  The amendment provides that the possible forms of awards under the Plan include awards paid in cash or awards paid in a combination of cash and equity, in addition to the existing provisions for awards made in any form of equity.  The amendment also clarifies that a delegation of authority from the Board to a Committee may be either a general delegation or a delegation for a specific occasion.

 

ITEM 13.CERTAIN RELATIONSHIPS, RELATED TRANSACTIONS AND DIRECTOR INDEPENDENCE

 

Cognate BioServicesCERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

 

Advent BioServices, Ltd.

Advent BioServices, Ltd. (“Advent”) is a related party based in the U.K. and owned by Toucan Holdings, which is controlled by our Chairperson and Chief Executive Officer, Linda F. Powers. Advent was previously the U.K. branch of Cognate until it was spun off from Cognate in late 2016. Since then, Advent has operated independently of Cognate, providing manufacturing and related services for production of DCVax-L products.

The Company had three operational programs with Advent: (a) an ongoing development and Cognate BioServices,manufacturing program at the GMP facility in London, (b) an affiliateongoing development and manufacturing program at the Sawston GMP facility, and (c) a one-time program for specialized work, organized into ten sets of one-time milestones, which were substantially completed as of December 31, 2023, for the following:

·Qualifying for and obtaining three required licenses for the Sawston facility: a license from the Human Tissue Authority to collect and process human cells and tissues, a license from the MHRA for manufacturing for clinical trials and compassionate use cases, and a license from the MHRA for commercial manufacturing.
·Six workstreams relating to product matters required for an application for regulatory approval of DCVax-L, including Comparability, Stability, Potency, Product Profile, Mechanism of Action and Fill/Finish.
·Drafting and submission of key portions of the first application for product approval (MAA).

Each of the Company, entered intothree operational programs is covered by a DCVax-Lseparate contract. The ongoing manufacturing in the London facility is covered by a Manufacturing Services Agreement a DCVax-Direct Manufacturing Services Agreement,(“MSA”) entered into on May 14, 2018. The development and manufacturing program at the Sawston facility is covered by an Ancillary Services Agreement and a Manufacturing Expansionentered into on November 18, 2019. The specialized work associated with the ten sets of one-time milestones is covered by an SOW 6 entered into under the Ancillary Services Agreement each effective as of January 17, 2014,April 1, 2022 and those agreements followedamended on September 26, 2022 and superseded ManufacturingSeptember 26, 2023. The 2023 amendment extended the SOW 6 service period for about six months, through March 31, 2024.


The Ancillary Services Agreements in 2011Agreement establishes a structure under which the Company and 2007. Those agreementsAdvent negotiate and agree upon the scope and terms for Statements of Work (“SOWs”) for facility development activities and compassionate use program activities. After an SOW is agreed and approved by the Company, Advent will proceed with, or continue, the applicable services and will invoice the Company pursuant to the SOW. Since both the facility development and the Company’s paymentscompassionate use program involve pioneering and uncertainties in most aspects, the invoicing under the Ancillary Services Agreement is on the basis of costs incurred plus fifteen percent. The SOWs may involve ongoing activities or specialized one-time projects and related one-time milestone payments. The Ancillary Services Agreement was to end in July 2023, but the Company extended the term by 12 months to July 2024 with no other changes.

SOW 6 provides for ongoing baseline costs for manufacturing at the Sawston facility and one-time milestone incentives for (a) regulatory approval of each of the three licenses required for the Sawston facility, (b) successful completion of each of the six workstreams and (c) completion of drafting key portions of applications for product approval. The milestone incentives are a combination of cash and stock, issuancesand are not paid until the milestone is achieved and earned.

During the year ended December 31, 2023, the Company paid an aggregate of $5.0 million in cash, of which $1.0 million was related to Cognate,two milestones that were completed and fully expensed in 2022, but was unpaid as wellof December 31, 2022, $4.0 million was payment for four completed one-time milestones (MAA workstream for Mechanism of Action, obtaining a commercial manufacturing license from the MHRA in March 2023 and completion of drafting key portions of the first application for commercial approval and submitting the application to MHRA for product approval). The Company issued 4.5 million common shares as vesting, lock-upa result of completion of the two one-time milestones (obtaining a commercial manufacturing license from the MHRA and other restrictions oncompletion of drafting and submitting the MAA application for approval in the U.K.) at fair value of $3.2 million, of which $0.6 million was recognized during the year ended December 31, 2023 and $2.6 million had already been recognized (but not paid) in 2022.

As of December 31, 2023, $0.5 million was unpaid and 1.5 million common shares accounts payablewere pending to Cognate, and loans made by Cognatebe issued in regard to the Company, are described in Note 9completed milestone (submission of the financial statements included in the Original Filing. Such footnote also describes the settlement of a short swing profit claim by Cognate.application to MHRA for product approval).

 

Review, approval or ratification of transactions with related personsRelated-Party Transaction Approval Policy

 

With respect to reviewing and approving related-party transactions, the Board reviews related-party transactions for potential conflicts of interests or other improprieties as well as for reasonableness. Under SEC rules, related-party transactions are those transactions to which we are or may be a party in which the amount involved exceeds the lesser of $120,000 or one percent of the average of our total assets at year-end for the last two completed fiscal years, and in which any of our directors or executive officers or any other related person had or will have a direct or indirect material interest, excluding, among other things, compensation arrangements with respect to employment or board membership. Any transactions with officers,any person who is, or at any time since the beginning of the Company’s fiscal year was, a director or executive officer or a nominee to become a director of the Company, any person who is known to be the beneficial owner of more than 5% of any class of the Company’s voting securities, any immediate family member or person sharing the household of any of the foregoing persons, any firm, corporation or other entity in which any of the foregoing persons is a partner or principal, is subject to approval or ratification in accordance with the procedures of the Company’s Related-Party Transaction Policy.

Conflicts Committee

The Conflicts Committee of the Board reviews and decides whether to approve all related-party matters and transactions in light of potential conflicts of interests and reasonableness, as described in the Corporate Governance Matters section above. The Conflicts Committee’s review and approval of any series of similar related-party transactions (such as a series of transactions governed by a single contract) can suffice to satisfy this policy with respect to each transaction in the series.

DIRECTOR INDEPENDENCE

Our Board of Directors has undertaken a review of the independence of our directors or 5% stockholders are on market-based terms, and are approved byhas determined that a majority of ourthe Board consists of members who are currently “independent” as that term is defined within the meaning of Section 5605(a)(2) of the Nasdaq Stock Market Rules. The Board of Directors has determined each of Messrs.  Malik and Sarma, and Ambassador Black to be independent. In addition, Jerry Jasinowski, who retired as a director on March 8, 2024, was independent and disinterested directors.during his service on the Board of Directors in 2023.


ITEM 14.PRINCIPAL ACCOUNTANT FEES AND SERVICES

 

PRINCIPAL ACCOUNTANT FEES AND SERVICES

Fees Paid to Marcum LLPIndependent Public Accountants

 

Marcum LLP was engaged in 2013 andCherry Bekaert has served as our independent public accounting firm for the fiscal years ended December 31, 20152020, 2021, 2022 and 2014.2023 and was engaged to serve in such capacity for 2024.

8

 

Audit Fees

 

The aggregate fees billed and unbilled offor the fiscal yearyears ended December 31, 2015 and 20142023 for professional services rendered by MarcumCherry Bekaeart for the audit of our annual financial statements for 2023, an independent audit of the Company’s internal controls for 2023, and the review of our financial statements included in our quarterly reports on Form 10-Q and consultations and consents were approximately $538,000 and $536,000, respectively.for 2023 was $614,000.

The aggregate fees billed in connection with the fiscal year ended December 31, 2022 for professional services rendered by Cherry Bekaert for the audit of our annual financial statement for 2022, including the review of the financial statement information included in our Quarterly Reports on Form 10-Q during 2022, was $550,000.

 

Audit-Related Fees

 

There were no fees billed in the fiscal yearyears ended December 31, 20152023 and 20142022 for assurance and related services rendered by MarcumCherry Bekaert related to the performance of the audit or review of our financial statements.

 

Tax and Other FeesNon-Audit Professional Services

 

There were no fees billed in the fiscal yearyears ended December 31, 20152023 and 20142022 for professional services rendered by MarcumCherry Bekaert for tax related services or other non-audit professional services fees.

 

Policy on Audit Committee Pre-Approval of Audit and Permissible Non-Audit Services

 

Consistent with SEC policies and guidelines regarding audit independence, the Audit Committee is responsible for the pre-approval of all audit and permissible non-audit services provided by our principal accountants on a case-by-case basis. Our Audit Committee has established a policy regarding approval of all audit and permissible non-audit services provided by our principal accountants. Our Audit Committee pre-approves these services by category and service. Our Audit Committee pre-approved all of the services provided by our principal accountants during the fiscal years ended December 31, 2015, 20142023 and 2013.2022.

PART IV

 

ITEM 15.EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

 

The Exhibits listed below are identified by numbers corresponding to the Exhibit Table of Item 601 of Regulation S-K. The Exhibits designated by an asterisk (*) are management contracts or compensatory plans or arrangements required to be filed pursuant to Item 15.

 


EXHIBIT INDEX

 

Exhibit


Number

 Description
3.1 Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to exhibitExhibit 3.1 filed with the Registrant’s Amendment No. 1 to the Registration Statement on Form S-1(File No. 333-134320) on July 17, 2006).
3.2 Third Amended and Restated Bylaws of the Company (incorporated by reference to exhibitExhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on June 22, 2007).
3.3 Amendment to Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to exhibitExhibit 3.2 filed with the Registrant’s Current Report on Form 8-K on June 22, 2007).
3.5 Amendment to Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to exhibitExhibit 3.1 filed with the Registrant’s Quarterly Report on Form 10-Q on May 21, 2012).
3.6 Amendment to Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to exhibitExhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on September 26, 2012).
3.73.61 Amendment to Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on January 13, 2023).
3.7Amendment to Third Amended and Restated Bylaws of the Company (incorporated by reference to exhibitExhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on December 11, 2012).
4.13.8 Amended and Restated Certificate of Designations of Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on December 21, 2017).
3.9Amended and Restated Certificate of Designations of Series B Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on January 4, 2018).
3.91Certificate of Elimination of the Series A Convertible Preferred Stock and Series B Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on July 26, 2022).
3.92Certificate of Designations of Series C Convertible Preferred Stock (incorporated by reference to Exhibit 3.2 filed with the Registrant’s Current Report on Form 8-K on July 26, 2022).
4.1Description of Securities
4.2Form of common stock certificate (incorporated by reference to exhibitExhibit 4.1 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001).
4.24.3 Form of Warrant Agency Agreement by and between Northwest Biopharmaceuticals, Inc. and Computershare Trust Company, N.A. and Form of Warrant Certificate (incorporated by reference to Exhibit 4.2 filed with the Registrant’s Form S-1 on December 4, 2012).
10.410.49 Form of Loan Agreement and 10% Convertible, Promissory Note between the Company and Toucan Partners, LLC (incorporated by reference to exhibit 10.4 filed with the Registrant’s Form 10-K on April 17, 2007)
10.5Second Amended and Restated Investor Rights Agreement dated June 22, 2007 between the Company and Toucan Capital Fund II, LLP (incorporated by reference to exhibit 10.3 filed with the Registrant’s Current Report on Form 8-K on June 22, 2007)
10.6Warrant to purchase securities of the Company dated July 26, 2005 issued to Toucan Capital Fund II, L.P (incorporated by reference to exhibit 10.3 filed with the Registrant’s Current Report on Form 8-K on August 1, 2005)
10.7Warrant to purchase securities of the Company dated September 7, 2005 issued to Toucan Capital Fund II, L.P (incorporated by reference to exhibit 10.3 filed with the Registrant’s Current Report on Form 8-K on September 9, 2005)
10.8Amended Form of Warrant to purchase securities of the Company dated November 14, 2005 and April 17, 2006, as amended April 14, 2007, issued to Toucan Partners, LLC (incorporated by reference to exhibit 10.21 filed with the Registrant’s Form 10-K on April 17, 2007)
10.9Form of Warrant to purchase securities of the Company dated April 14, 2007 issued to Toucan Partners, LLC (incorporated by reference to exhibit 10.22 filed with the Registrant’s Form 10-K on April 17, 2007)
10.10Loan Agreement and 10% Convertible Promissory Note in the principal amount of $100,000 between the Company and Toucan Partners, LLC, dated April 27, 2007 (incorporated by reference to exhibit 10.1 filed with the Registrant’s Current Report on Form 8-K on May 3, 2007)
10.11Warrant to purchase securities of the Company issued to Toucan Partners, LLC, dated April 27, 2007 (incorporated by reference to exhibit 10.2 filed with the Registrant’s Current Report on Form 8-K on May 3, 2007)
10.12Form of Toucan Partners Loan Agreement and 10% Convertible Note, dated as of June 1, 2007 (incorporated by reference to exhibit 10.1 filed with the Registrant’s Current Report on Form 8-K on June 7, 2007)
10.13Form of Toucan Partners Warrant, dated as of June 1, 2007 (incorporated by reference to exhibit 10.2 filed with the Registrant’s Current Report on Form 8-K on June 7, 2007)
10.14Amended and Restated Warrant to purchase Series A Preferred Stock issued to Toucan Capital Fund II, L.P., dated as of June 1, 2007 (incorporated by reference to exhibit 10.3 filed with the Registrant’s Current Report on Form 8-K on June 7, 2007)
10.15Warrant to purchase Series A-1 Preferred Stock issued to Toucan Capital Fund II, L.P., dated as of June 1, 2007 (incorporated by reference to exhibit 10.4 filed with the Registrant’s Current Report on Form 8-K on June 7, 2007)
10.16Warrant to purchase Series A-1 Preferred Stock issued to Toucan Capital Fund II, L.P., dated as of June 1, 2007 (incorporated by reference to exhibit 10.5 filed with the Registrant’s Current Report on Form 8-K on June 7, 2007)
10.17Northwest Biotherapeutics, Inc. $225,000 Demand Note dated June 13, 2007 (incorporated by reference to exhibit 10.1 filed with the Registrant’s Current Report on Form 8-K on June 18, 2007)
10.18Conversion Agreement dated June 15, 2007 and effective June 22, 2007 between the Company and Toucan Capital Fund II, LLP (incorporated by reference to exhibit 10.1filed with the Registrant’s Current Report on Form 8-K on June 22, 2007)
10.19*Services Agreement between Cognate BioServices, Inc. and Northwest Biotherapeutics dated April 1, 2011 (incorporated by reference to exhibit 10.19 filed with the Registrant’s Registration Statement on Form S-1 (Registration No. 333-182470 on June 29, 2012)

9

Exhibit

Number

Description
10.201998 Stock Option Plan (incorporated by reference to exhibit 10.15 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001)
10.211999 Executive Stock Option Plan (incorporated by reference to exhibit 10.16 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001)
10.222001 Stock Option Plan (incorporated by reference to exhibit 10.17 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001)
10.232001 Nonemployee Director Stock Incentive Plan (incorporated by reference to exhibit 10.18 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001)
10.24EmployeeE Common Stock Purchase Plan (incorporated by reference to exhibit 10.19 filed with the Registrant’s Amendment No. 3 to the Registration Statement on Form S-1 (Registration No. 333-67350) on November 14, 2001)
10.25Form of Stock Option Agreement under the 2007 Stock Option Plan (incorporated by reference to exhibit 10.2 filed with the Registrant’s Registration Statement on Form S-8 on November 21, 2007)
10.26Loan Agreement and Promissory Note, dated May 6, 2008 between the Company and Al Rajhi Holdings WLL (incorporated by reference to exhibit 4.5 filed with the Registrant’s Current Report on Form 8-K on May 15, 2008)
10.27Loan Agreement and Promissory Note, dated August 19, 2008 between the Company and Toucan Partners LLC (incorporated by reference to exhibit 10.1 filed with the Registrant’s Quarterly Report on Form 10-Q on August 19, 2008)
10.28Loan Agreement and Promissory Note, dated October 1, 2008 between the Company and SDS Capital Group SPC, Ltd (incorporated by reference to exhibit 10.2 filed with the Registrant’s Quarterly Report on Form 10-Q on November 19, 2008)
10.29Warrant dated October 1, 2008, between the Company and SDS Capital Group SPC, Ltd (incorporated by reference to exhibit 10.3 filed with the Registrant’s Quarterly Report on Form 10-Q on November 19, 2008)
10.30Loan Agreement and Promissory Note, dated October 21, 2008, between the Company and SDS Capital Group SPC, Ltd (incorporated by reference to exhibit 10.4 filed with the Registrant’s Quarterly Report on Form 10-Q on November 19, 2008)
10.31Form of Loan Agreement and Promissory Note, between the Company and a Group of Private Investors (incorporated by reference to exhibit 10.5 filed with the Registrant’s Quarterly Report on Form 10-Q on November 19, 2008)
10.32Form of Warrant, between the Company and SDS Capital Group SPC. Ltd and a Group of Private Investors (incorporated by reference to exhibit 10.6 filed with the Registrant’s Quarterly Report on Form 10-Q on November 19, 2008)
10.33Loan Agreement and Promissory Note, dated December 22, 2008, between the Company and Toucan Partners LLC (incorporated by reference to exhibit 10.62 filed with the Registrant’s Form 10-K on April 15, 2009)
10.34Form of Warrant, dated December 22, 2008, between the Company and Toucan Partners LLC (incorporated by reference to exhibit 10.63 filed with the Registrant’s Form 10-K on April 15, 2009)
10.35Form of Securities Purchase Agreement, by and among the Company and Al Rajhi Holdings (incorporated by reference to exhibit 10.64 filed with the Registrant’s Form 10-K on April 15, 2009)
10.36Securities Purchase Agreement, by and among the Company and a Group of Equity Investors (incorporated by reference to exhibit 10.65 filed with the Registrant’s Form 10-K on April 15, 2009)
10.37Form of Warrant, between the Company and a Group of Equity Investors (incorporated by reference to exhibit 10.66 filed with the Registrant’s Form 10-K on April 15, 2009)
10.38Form of Loan Agreement and Promissory Note, dated March 27 2009, between the Company and a Group of Private Lenders (incorporated by reference to exhibit 10.67 filed with the Registrant’s Form 10-K on April 15, 2009)
10.39Amended and Restated Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (incorporated by reference to Schedule 14A filed on December 3, 2013)
10.40DC Vax ®-L Manufacturing and Services Agreement between the Company and Cognate BioServices, Inc. dated January 17, 2014 (incorporated by reference to Exhibit 10.40 filed with the Company’s Quarterly Report on Form 10-Q on May 15, 2014).
10.41DC Vax ®-L Direct Manufacturing and Services Agreement between the Company and Cognate BioServices, Inc. dated January 17, 2014 (incorporated by reference to Exhibit 10.41 filed with the Company’s Quarterly Report on Form 10-Q on May 15, 2014).
10.42Ancillary Services Agreement between the Company and Cognate BioServices, Inc. dated January 17, 2014 (incorporated by reference to Exhibit 10.42 filed with the Company’s Quarterly Report on Form 10-Q on May 15, 2014).
10.43Manufacturing Expansion Service Agreement between the Company and Cognate BioServices, Inc. dated January 17, 2014 (incorporated by reference to Exhibit 10.43 filed with the Company’s Quarterly Report on Form 10-Q on May 15, 2014).
10.44Form of Warrant between the Company and H.C. Wainwright & Co., LLC dated April 9, 2014 (incorporated by reference to Exhibit 4.1 filed with the Company’s Quarterly Report on Form 10-Q on May 15, 2014).

10

Exhibit

Number

Description
10.45Securities Purchase Agreement between the Company and certain investors dated April 9, 2014 (incorporated by reference to Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on April 14, 2014)
10.46Placement Agreement between the Company and H.C. Wainwright & Co., LLC (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K8-K/A on April 14, 2014)September 19, 2016).
10.4710.50 Form of PurchaseRegistration Rights Agreement for 5.00% Convertible Senior Notes between the Company and certain investors dated August 13, 201422, 2016 (incorporated by reference as Exhibit 1.110.3 filed with the Company’s Current Report on Form 8-K8-K/A on AugustSeptember 19, 2014.)2016).
10.4810.64 Form of Indenture between the Company and The Bank of New York Mellon, as Trustee,Warrant Repricing Letter Agreement dated August 19, 2014 (incorporated7, 2017 by reference as Exhibit 4.1 filed with the Company’s Current Report on Form 8-K on August 25, 2014.)
10.49Pledge and Escrow between the CompanyNorthwest Biotherapeutics, Inc. and The Bank of New York Mellon, as Trustee, dated August 19, 2014a certain institutional investor (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on August 25, 2014.)7, 2017).
10.5010.65 Form of Series A Common Stock Purchase Warrant between the Company and certain investors (incorporated by reference as Exhibit 4.110.2 filed with the Company’s Current Report on Form 8-K on October 10, 2014.)August 7, 2017).
10.5110.66 StockForm of Securities Purchase Amendment and Issuance Agreement, dated October 6, 2014September 20, 2017, by and between Northwest Biotherapeutics, Inc. and certain institutional investors (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on October 10, 2014.)September 22, 2017).
10.5210.67 Amendment to Engagement Letter between the Company H.C. Wainwright & Co., LLC dated October 6, 2014Form of Class A Common Stock Purchase Warrant (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on October 10, 2014.)September 22, 2017).
10.5310.70 SecuritiesForm of Class D-1 Common Stock Purchase Agreement dated December 22, 2015 by and between Northwest Biotherapeutics, Inc. and certain purchasersWarrant (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on December 29, 2015.)7, 2017).
10.5410.72 Form of Warrant between the Company and certain investors (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on December 29, 2015).
10.55EngagementSubscription Agreement dated November 16, 2015, by and between Northwest Biotherapeutics, Inc. and H.C. Wainwright & Co., as placement agent purchasers (incorporated by reference as Exhibit 10.3 filed with the Company’s Current Report on Form 8-K on December 29, 2015)7, 2017).
10.5510.73 Settlement and Amendment to Engagement Agreement (2016 Obligations Agreement), dated as of December 22, 2015,31, 2017, by and between Northwest Biotherapeutics, Inc. and H.C. WainwrightCognate BioServices, Inc. 
10.74Settlement and Amendment Agreement (2017 Obligations Agreement), dated as of December 31, 2017, by and between Northwest Biotherapeutics, Inc. and Cognate BioServices, Inc.

21

10.75Note and Loan Agreement, dated as of March 14, 2018, by and between Northwest Biotherapeutics, Inc. and Linda F. Powers.
10.76Note and Loan Agreement, dated as of March 19, 2018, by and between Northwest Biotherapeutics, Inc. and Linda F. Powers.
10.78Form of Loan Agreement, dated as of November 7, 2018, by and between Northwest Biotherapeutics, Inc. and a Group of Private Lenders.
10.79Contract Relating to Sale of Spicers, Sawston, Cambridge, dated as of December 5, 2018, by and between Aracaris Capital Limited and Huawei Technologies Research & Co.,Development (UK) Limited.
10.80Lease Relating to Vision Centre, Sawston, Cambridge, by and between Aracaris Capital Limited and Aracaris Limited, dated as placement agentof December 14, 2018.
10.81Equity Compensation Plan, dated May 29, 2020.
10.82Note and Loan Agreement, dated August 14, 2021, by and between Northwest Biotherapeutics, Inc. and Iliad Research and Trading L.P.
10.83Agreement to acquire Flaskworks, L.L.C, August 28, 2020.
10.84Change in Registrant’s Accountants (incorporated by reference as Exhibit 10.416.1 filed with the Company’s Current Report on Form 8-K on December 29, 2015)January 26, 2021).
10.5610.85 Form of Securities PurchaseLoan Agreement, dated February 29, 2016March 1, 2021, by and between Northwest Biotherapeutics, Inc. and certain purchasers (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on March 3, 2016).Streeterville Capital, L.L.C.
10.5710.86 Form of Warrant between the Company and certain investors (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on March 3, 2016).
10.58EngagementLoan Agreement, dated February 29, 2016,November 22, 2021, by and between Northwest Biotherapeutics, Inc. and H.C. Wainwright & Co., LLC, as placement agentStreeterville Capital, L.L.C (incorporated by reference asto Exhibit 10.310.86 filed with the Company’s Current Report on Form 8-K on March 3, 2016).
21.1Subsidiaries of the Registrant(incorporated by reference as Exhibit 21.1 filed with the Company’sRegistrant’s Annual Report on Form 10-K,10 - K on March 1, 2022).
10.87Sub-lease Agreement, dated December 31, 2021, by and between Aracaris Ltd. and Northwest Biotherapeutics, Inc. (collectively the “Sub-Lessor”) and Advent BioServices, Ltd. (the “Sub-Lessee”).
10.88Loan Agreement, dated September 26, 2022, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C (incorporated by reference to Exhibit 10.88 filed with the CommissionRegistrant’s Annual Report on March 16, 2016)Form 10 - K on February 28, 2023).
31.110.89 Loan Agreement, dated March 2, 2023, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.
10.90Loan Agreement, dated November 10, 2023, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.
21.1Subsidiaries of the Registrant.
23.1Independent Registered Public Accounting Firm’s Consent.
31.1Certification of the Principal Executive and Principal Financial and Accounting Officer pursuant to Section 302 of the Sarbanes Oxley Act of 20022002.
32.1 Certification of the Principal Executive and Principal Financial and Accounting Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 20022002.

101.INS Inline XBRL Instance Document (incorporated by reference as Exhibit 101.INS filed with the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Document.
101.SCH Inline XBRL Schema Document (incorporated by reference as Exhibit 101.SCH filed with the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Document.
101.CAL Inline XBRL Calculation Linkbase Document (incorporated by reference as Exhibit 101.CAL filed with the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Document.
101.DEF Inline XBRL Definition Linkbase Document (incorporated by reference as Exhibit 101.DEF filed with the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Document.
101.LAB Inline XBRL Label Linkbase Document (incorporated by reference as Exhibit 101.LAB filed with the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Document.
101.PRE Inline XBRL Presentation Linkbase Document(incorporated by reference as Exhibit 101.PRE filed withDocument.
104Cover Page Interactive Data File (Embedded within the Company’s Annual Report on Form 10-K, filed with the Commission on March 16, 2016).Inline XBRL document and included in Exhibit)

 

*

Confidential information in this exhibit has been omitted and filed separately with the SEC pursuant to a confidential treatment request.

 

11

ITEM 16. FORM 10-K SUMMARY

 

None.

SIGNATURES

 

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Annual Report on Form 10-KAmendment to be signed on its behalf by the undersigned, thereunto duly authorized.

 

NORTHWEST BIOTHERAPEUTICS, INC.

(Registrant)

Date: April 29, 20162024By:/s/ Linda F. Powers
Linda F. Powers,

President and Chief Executive Officer and President (Principal

Principal Executive Officer and

Principal Financial and Accounting Officer)Officer

 

Pursuant to the requirements of the Securities Exchange Act of 1934, this Annual Report on Form 10-K has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.

SignatureTitleDate
/s/ Linda F. PowersChief Executive Officer and President (PrincipalApril 29, 2016
Linda F. PowersExecutive Officer and Principal Financial
and Accounting Officer)
/s/ Alton L. BoyntonDirectorApril 29, 2016
Alton L. Boynton
/s/ Robert A. FarmerDirectorApril 29, 2016
Robert A. Farmer
/s/ Navid MalikDirectorApril 29, 2016
Dr. Navid Malik
/s/ Jerry JasinowskiDirectorApril 29, 2016
Jerry Jasinowski
/s/ Susan B. BayhDirectorApril 29, 2016
Susan B. Bayh
/s/ J. Cofer BlackDirectorApril 29, 2016
J. Cofer Black