UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q


(Mark One)
☒			QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the Quarterly Period Ended ~~June~~September 30, 2020


☐			TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-35060

PACIRA BIOSCIENCES, INC.

(Exact Name of Registrant as Specified in its Charter)


Delaware						51-0619477
(State or Other Jurisdiction of Incorporation or Organization)						(I.R.S. Employer Identification No.)

5 Sylvan Way, Suite 300

Parsippany, New Jersey, 07054

(Address and Zip Code of Principal Executive Offices)

(973) 254-3560

(Registrant’s Telephone Number, Including Area Code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading symbol

Name of each exchange on which registered

Common Stock, par value $0.001 per share

PCRX

Nasdaq Global Select Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes ☐ No

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files.) ☒ Yes ☐ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company”, and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

☒

Accelerated filer

☐

Non-accelerated filer

☐

Smaller reporting company

☐

Emerging growth company

☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ☐ Yes ☒ No

As of ~~August 2,~~October 25, 2020, ~~42,742,176~~43,443,699 shares of the registrant’s common stock, $0.001 par value per share, were outstanding.

Table of Contents

PACIRA BIOSCIENCES, INC.

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTER ENDED ~~JUNE~~SEPTEMBER 30, 2020

TABLE OF CONTENTS

Page #

PART I. FINANCIAL INFORMATION

Item 1.

Financial Statements (Unaudited)

Condensed Consolidated Balance Sheets

Condensed Consolidated Statements of Operations

Condensed Consolidated Statements of Comprehensive Income ~~(Loss~~(Loss))

Condensed Consolidated Statements of Stockholders’ Equity

Condensed Consolidated Statements of Cash Flows

Condensed Notes to Consolidated Financial Statements

1011

Item 2.

Management’s Discussion and Analysis of Financial Condition and Results of Operations

2731

Item 3.

Quantitative and Qualitative Disclosures About Market Risk

4145

Item 4.

Controls and Procedures

4246

PART II. OTHER INFORMATION

Unregistered Sales of Equity Securities and Use of Proceeds

4448

Item 3.

Defaults Upon Senior Securities

4448

Item 4.

Mine Safety Disclosures

PART I — FINANCIAL INFORMATION

Item 1. FINANCIAL STATEMENTS (Unaudited)

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands, except share and per share amounts)

(Unaudited)


ASSETS	ASSETS	June 30, 2020		December 31, 2019		ASSETS	September 30, 2020		December 31, 2019
Current assets:	Current assets:					Current assets:
Cash and cash equivalents	Cash and cash equivalents	$	78,552	$	78,228	Cash and cash equivalents	$	125,244	$	78,228
Short-term investments	Short-term investments	248,240		213,722		Short-term investments	406,881		213,722
Accounts receivable, net	Accounts receivable, net	44,013		47,530		Accounts receivable, net	46,143		47,530
Inventories, net	Inventories, net	66,690		58,296		Inventories, net	68,542		58,296
Prepaid expenses and other current assets	Prepaid expenses and other current assets	18,328		10,781		Prepaid expenses and other current assets	11,710		10,781
Total current assets	Total current assets	455,823		408,557		Total current assets	658,520		408,557
Long-term investments	Long-term investments	8,261		64,798		Long-term investments	44,062		64,798
Fixed assets, net	Fixed assets, net	113,297		104,681		Fixed assets, net	125,527		104,681
Right-of-use assets, net	Right-of-use assets, net	77,799		38,124		Right-of-use assets, net	76,047		38,124
Goodwill	Goodwill	99,547		99,547		Goodwill	99,547		99,547
Intangible assets, net	Intangible assets, net	100,454		104,387		Intangible assets, net	98,487		104,387
Deferred tax assets						Deferred tax assets	104,122		0
Equity investment and other assets	Equity investment and other assets	10,930		10,971		Equity investment and other assets	13,957		10,971
Total assets	Total assets	$	866,111	$	831,065	Total assets	$	1,220,269	$	831,065

LIABILITIES AND STOCKHOLDERS’ EQUITY	LIABILITIES AND STOCKHOLDERS’ EQUITY					LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:	Current liabilities:					Current liabilities:
Accounts payable	Accounts payable	$	9,160	$	12,799	Accounts payable	$	13,008	$	12,799
Accrued expenses	Accrued expenses	47,684		70,427		Accrued expenses	60,403		70,427
Lease liabilities	Lease liabilities	7,620		4,935		Lease liabilities	7,455		4,935

Contingent consideration	Contingent consideration	4,504		18,179		Contingent consideration	5,406		18,179
Income taxes payable	Income taxes payable	1,615		1,333		Income taxes payable	0		1,333
Total current liabilities	Total current liabilities	70,583		107,673		Total current liabilities	86,272		107,673
Convertible senior notes	Convertible senior notes	314,182		306,045		Convertible senior notes	456,464		306,045
Lease liabilities	Lease liabilities	73,888		40,938		Lease liabilities	72,448		40,938
Contingent consideration	Contingent consideration	16,326		19,963		Contingent consideration	16,176		19,963
Other liabilities	Other liabilities	2,984		1,502		Other liabilities	4,219		1,502
Total liabilities	Total liabilities	477,963		476,121		Total liabilities	635,579		476,121
Commitments and contingencies (Note 16)	Commitments and contingencies (Note 16)					Commitments and contingencies (Note 16)
Stockholders’ equity:	Stockholders’ equity:					Stockholders’ equity:
Preferred stock, par value $0.001; 5,000,000 shares authorized; NaN issued and outstanding at June 30, 2020 and December 31, 2019		—		—
Common stock, par value $0.001; 250,000,000 shares authorized; 42,608,257 shares issued and outstanding at June 30, 2020; 41,908,148 shares issued and outstanding at December 31, 2019		43		42
Preferred stock, par value $0.001; 5,000,000 shares authorized; NaN issued and outstanding at September 30, 2020 and December 31, 2019						Preferred stock, par value $0.001; 5,000,000 shares authorized; NaN issued and outstanding at September 30, 2020 and December 31, 2019	0		0
Common stock, par value $0.001; 250,000,000 shares authorized; 43,312,638 shares issued and outstanding at September 30, 2020; 41,908,148 shares issued and outstanding at December 31, 2019						Common stock, par value $0.001; 250,000,000 shares authorized; 43,312,638 shares issued and outstanding at September 30, 2020; 41,908,148 shares issued and outstanding at December 31, 2019	43		42
Additional paid-in capital	Additional paid-in capital	785,124		753,978		Additional paid-in capital	852,190		753,978
Accumulated deficit	Accumulated deficit	(398,509)		(399,398)		Accumulated deficit	(268,390)		(399,398)
Accumulated other comprehensive income	Accumulated other comprehensive income	1,490		322		Accumulated other comprehensive income	847		322
Total stockholders’ equity	Total stockholders’ equity	388,148		354,944		Total stockholders’ equity	584,690		354,944
Total liabilities and stockholders’ equity	Total liabilities and stockholders’ equity	$	866,111	$	831,065	Total liabilities and stockholders’ equity	$	1,220,269	$	831,065

See accompanying condensed notes to consolidated financial statements.

Table of Contents

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)

(Unaudited)


		Three Months Ended June 30,						Six Months Ended June 30,							Three Months Ended September 30,				Nine Months Ended September 30,
		2020		2019		2020		2019			2020		2019		2020		2019
Revenues:	Revenues:									Revenues:
Net product sales	Net product sales	$	75,216	$	101,824	$	179,961	$	192,730	Net product sales	$	116,889	$	104,350	$	296,850	$	297,080

Royalty revenue	Royalty revenue	289		780		1,228		1,187		Royalty revenue	595		335		1,823		1,522
Total revenues	Total revenues	75,505		102,604		181,189		193,917		Total revenues	117,484		104,685		298,673		298,602
Operating expenses:	Operating expenses:									Operating expenses:
Cost of goods sold	Cost of goods sold	22,305		25,201		52,037		52,505		Cost of goods sold	29,993		22,304		82,031		74,809
Research and development	Research and development	13,620		17,827		29,440		32,210		Research and development	14,651		20,255		44,090		52,466
Selling, general and administrative	Selling, general and administrative	43,342		49,126		88,122		96,431		Selling, general and administrative	52,561		50,128		140,683		146,559
Amortization of acquired intangible assets	Amortization of acquired intangible assets	1,967		1,770		3,933		1,770		Amortization of acquired intangible assets	1,967		1,967		5,900		3,736
Acquisition-related charges (gains) and product discontinuation, net	Acquisition-related charges (gains) and product discontinuation, net	1,418		3,405		(2,290)		4,647		Acquisition-related charges (gains) and product discontinuation, net	692		7,618		(1,599)		12,266
Total operating expenses	Total operating expenses	82,652		97,329		171,242		187,563		Total operating expenses	99,864		102,272		271,105		289,836
Income (loss) from operations		(7,147)		5,275		9,947		6,354
Income from operations										Income from operations	17,620		2,413		27,568		8,766
Other (expense) income:	Other (expense) income:									Other (expense) income:
Interest income	Interest income	1,323		1,817		2,911		3,973		Interest income	1,025		1,736		3,936		5,709
Interest expense	Interest expense	(5,456)		(5,878)		(11,477)		(11,691)		Interest expense	(7,132)		(5,940)		(18,609)		(17,631)

Loss on early extinguishment of debt										Loss on early extinguishment of debt	(8,071)		0		(8,071)		0
Other, net	Other, net	3,969		(87)		(136)		(26)		Other, net	2,708		(4,025)		2,571		(4,051)
Total other expense, net	Total other expense, net	(164)		(4,148)		(8,702)		(7,744)		Total other expense, net	(11,470)		(8,229)		(20,173)		(15,973)
Income (loss) before income taxes	Income (loss) before income taxes	(7,311)		1,127		1,245		(1,390)		Income (loss) before income taxes	6,150		(5,816)		7,395		(7,207)
Income tax benefit (expense)	Income tax benefit (expense)	42		1,603		(356)		1,349		Income tax benefit (expense)	123,969		(271)		123,613		1,079
Net income (loss)	Net income (loss)	$	(7,269)	$	2,730	$	889	$	(41)	Net income (loss)	$	130,119	$	(6,087)	$	131,008	$	(6,128)

Net income (loss) per share:	Net income (loss) per share:									Net income (loss) per share:
Basic net income (loss) per common share	Basic net income (loss) per common share	$	(0.17)	$	0.07	$	0.02	$	(0.00)	Basic net income (loss) per common share	$	3.03	$	(0.15)	$	3.09	$	(0.15)
Diluted net income (loss) per common share	Diluted net income (loss) per common share	$	(0.17)	$	0.06	$	0.02	$	(0.00)	Diluted net income (loss) per common share	$	2.94	$	(0.15)	$	3.02	$	(0.15)
Weighted average common shares outstanding:	Weighted average common shares outstanding:									Weighted average common shares outstanding:
Basic	Basic	42,221		41,384		42,126		41,312		Basic	42,928		41,645		42,393		41,423
Diluted	Diluted	42,221		42,345		42,861		41,312		Diluted	44,275		41,645		43,333		41,423

See accompanying condensed notes to consolidated financial statements.

Table of Contents

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)

(In thousands)

(Unaudited)

Three Months Ended
June 30, Six Months Ended
June 30,
2020 2019 2020 2019
Net income (loss) $ (7,269) $ 2,730 $ 889 $ (41)
Other comprehensive income:
Net unrealized gain on investments 2,536 318 1,168 780
Total other comprehensive income 2,536 318 1,168 780
Comprehensive income (loss) $ (4,733) $ 3,048 $ 2,057 $ 739


	Three Months Ended September 30,				Nine Months Ended September 30,
	2020		2019		2020		2019
Net income (loss)	$	130,119	$	(6,087)	$	131,008	$	(6,128)
Other comprehensive income (loss):
Net unrealized gain (loss) on investments	(643)		(53)		525		727
Total other comprehensive income (loss)	(643)		(53)		525		727
Comprehensive income (loss)	$	129,476	$	(6,140)	$	131,533	$	(5,401)

See accompanying condensed notes to consolidated financial statements.

Table of Contents

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

FOR THE THREE MONTHS ENDED ~~JUNE~~SEPTEMBER 30, 2020 AND 2019

(In thousands)

(Unaudited)


		Common Stock					Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)					Common Stock							Additional Paid-In Capital			Accumulated Deficit				Accumulated Other Comprehensive Income (Loss)
		Shares	Amount												Total			Shares			Amount				Additional Paid-In Capital			Accumulated Deficit				Accumulated Other Comprehensive Income (Loss)				Total
Balance at March 31, 2020		42,117	$	42	$	766,280	$	(391,240)	$	(1,046)	$	374,036
Balance at June 30, 2020													Balance at June 30, 2020	42,608		$	43		$	785,124			$	(398,509)				$	1,490			$	388,148

Exercise of stock options	Exercise of stock options	220	1		8,201		—		—		8,202		Exercise of stock options	703		0			24,582				—			—				24,582
Vested restricted stock units	Vested restricted stock units	234	—		—		—		—		—		Vested restricted stock units	2		—			—				—			—				0
Shares issued under employee stock purchase plan		37	—		1,421		—		—		1,421

Stock-based compensation													Stock-based compensation	—		—			10,954				—			—				10,954

Retirement of equity component of 2022 convertible senior notes (Note 9)													Retirement of equity component of 2022 convertible senior notes (Note 9)	—		—			(33,089)				—			—				(33,089)
Equity component of 2025 convertible senior notes issued, net of deferred taxes of $20,450 (Note 9)													Equity component of 2025 convertible senior notes issued, net of deferred taxes of $20,450 (Note 9)	—		—			64,619				—			—				64,619
Net unrealized loss on investments													Net unrealized loss on investments	—		—			—				—			(643)				(643)
Net income													Net income	—		—			—				130,119			—				130,119
Balance at September 30, 2020													Balance at September 30, 2020	43,313		$	43		$	852,190			$	(268,390)		$	847			$	584,690

														Common Stock					Additional Paid-In Capital				Accumulated Deficit			Accumulated Other Comprehensive Income (Loss)
														Shares		Amount									Total
Balance at June 30, 2019													Balance at June 30, 2019	41,606		$	42				$	729,531				$	(388,423)			$	500			$	341,650

Exercise of stock options													Exercise of stock options	92		—			1,408				—			—				1,408
Vested restricted stock units													Vested restricted stock units	2		—			—				—			—				0

Stock-based compensation	Stock-based compensation	—	—		9,222		—		—		9,222		Stock-based compensation	—		—			9,244				—			—				9,244

Net unrealized gain on investments		—	—		—		—		2,536		2,536
Net unrealized loss on investments													Net unrealized loss on investments	—		—			—				—			(53)				(53)
Net loss	Net loss	—	—		—		(7,269)		—		(7,269)		Net loss	—		—			—				(6,087)			—				(6,087)
Balance at June 30, 2020		42,608	$	43	$	785,124	$	(398,509)	$	1,490	$	388,148

		Common Stock					Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)
		Shares	Amount												Total
Balance at March 31, 2019		41,289	$	41	$	718,449	$	(391,153)	$	182	$	327,519

Exercise of stock options		97	—		2,029		—		—		2,029
Vested restricted stock units		184	1		—		—		—		1
Shares issued under employee stock purchase plan		36	—		1,270		—		—		1,270
Stock-based compensation		—	—		7,783		—		—		7,783

Net unrealized gain on investments		—	—		—		—		318		318
Net income		—	—		—		2,730		—		2,730
Balance at June 30, 2019		41,606	$	42	$	729,531	$	(388,423)	$	500	$	341,650
Balance at September 30, 2019													Balance at September 30, 2019	41,700		$	42		$	740,183			$	(394,510)		$	447			$	346,162

See accompanying condensed notes to consolidated financial statements.

Table of Contents

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

FOR THE ~~SIX~~NINE MONTHS ENDED ~~JUNE~~SEPTEMBER 30, 2020 AND 2019

(In thousands)

(Unaudited)


		Common Stock						Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)					Common Stock						Additional Paid-In Capital			Accumulated Deficit			Accumulated Other Comprehensive Income (Loss)
		Shares	Amount													Total			Shares			Amount			Additional Paid-In Capital			Accumulated Deficit			Accumulated Other Comprehensive Income (Loss)	Total
Balance at December 31, 2019	Balance at December 31, 2019	41,908	$	42		$	753,978	$	(399,398)	$	322	$	354,944	Balance at December 31, 2019	41,908		$	42		$	753,978		$	(399,398)		$	322		$	354,944

Exercise of stock options	Exercise of stock options	427	1			11,655		—		—		11,656		Exercise of stock options	1,130		1			36,237			—			—			36,238
Vested restricted stock units	Vested restricted stock units	236	—			—		—		—		—		Vested restricted stock units	238		—			—			—			—			0
Shares issued under employee stock purchase plan	Shares issued under employee stock purchase plan	37	—		—	1,421		—		—		1,421		Shares issued under employee stock purchase plan	37		—			1,421			—			—			1,421
Stock-based compensation	Stock-based compensation	—	—			18,070		—		—		18,070		Stock-based compensation	—		—			29,024			—			—			29,024

Retirement of equity component of 2022 convertible senior notes (Note 9)														Retirement of equity component of 2022 convertible senior notes (Note 9)	—		—			(33,089)			—			—			(33,089)
Equity component of 2025 convertible senior notes issued, net of deferred taxes of $20,450 (Note 9)														Equity component of 2025 convertible senior notes issued, net of deferred taxes of $20,450 (Note 9)	—		—			64,619			—			—			64,619
Net unrealized gain on investments	Net unrealized gain on investments	—	—			—		—		1,168		1,168		Net unrealized gain on investments	—		—			—			—			525			525
Net income	Net income	—	—			—		889		—		889		Net income	—		—			—			131,008			—			131,008
Balance at June 30, 2020		42,608	$	43		$	785,124	$	(398,509)	$	1,490	$	388,148
Balance at September 30, 2020														Balance at September 30, 2020	43,313		$	43		$	852,190		$	(268,390)		$	847		$	584,690


		Common Stock					Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)					Common Stock						Additional Paid-In Capital			Accumulated Deficit			Accumulated Other Comprehensive Income (Loss)
		Shares	Amount												Total			Shares			Amount			Additional Paid-In Capital			Accumulated Deficit			Accumulated Other Comprehensive Income (Loss)	Total
Balance at December 31, 2018	Balance at December 31, 2018	41,223	$	41	$	709,691	$	(388,226)	$	(280)	$	321,226	Balance at December 31, 2018	41,223		$	41		$	709,691		$	(388,226)		$	(280)		$	321,226
Cumulative effect adjustment of the adoption of Accounting Standards Update 2016-02 (Note 2)	Cumulative effect adjustment of the adoption of Accounting Standards Update 2016-02 (Note 2)	—	—		—		(156)		—		(156)		Cumulative effect adjustment of the adoption of Accounting Standards Update 2016-02 (Note 2)	—		—			—			(156)			—			(156)
Exercise of stock options	Exercise of stock options	159	—		3,586		—		—		3,586		Exercise of stock options	251		1			4,994			—			—			4,995
Vested restricted stock units	Vested restricted stock units	188	1		—		—		—		1		Vested restricted stock units	190		0			—			—			—			0
Shares issued under employee stock purchase plan	Shares issued under employee stock purchase plan	36	—		1,270		—		—		1,270		Shares issued under employee stock purchase plan	36		—			1,270			—			—			1,270
Stock-based compensation	Stock-based compensation	—	—		15,217		—		—		15,217		Stock-based compensation	—		—			24,461			—			—			24,461

Retirement of equity component of 2019 convertible senior notes	Retirement of equity component of 2019 convertible senior notes	—	—		(233)		—		—		(233)		Retirement of equity component of 2019 convertible senior notes	—		—			(233)			—			—			(233)

Net unrealized gain on investments	Net unrealized gain on investments	—	—		—		—		780		780		Net unrealized gain on investments	—		—			—			—			727			727
Net loss	Net loss	—	—		—		(41)		—		(41)		Net loss	—		—			—			(6,128)			—			(6,128)
Balance at June 30, 2019		41,606	$	42	$	729,531	$	(388,423)	$	500	$	341,650
Balance at September 30, 2019													Balance at September 30, 2019	41,700		$	42		$	740,183		$	(394,510)		$	447		$	346,162

See accompanying condensed notes to consolidated financial statements.

Table of Contents

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)


		Six Months Ended June 30,							Nine Months Ended September 30,
		2020		2019			2020		2019
Operating activities:	Operating activities:					Operating activities:
Net income (loss)	Net income (loss)	$	889	$	(41)	Net income (loss)	$	131,008	$	(6,128)
Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities:
Adjustments to reconcile net income (loss) to net cash provided by operating activities:						Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Reversal of deferred tax valuation allowance						Reversal of deferred tax valuation allowance	(124,572)		0
Depreciation of fixed assets and amortization of intangible assets	Depreciation of fixed assets and amortization of intangible assets	9,810		8,881		Depreciation of fixed assets and amortization of intangible assets	14,847		14,486
Amortization of debt issuance costs	Amortization of debt issuance costs	883		844		Amortization of debt issuance costs	1,512		1,273
Amortization of debt discount	Amortization of debt discount	7,254		6,749		Amortization of debt discount	12,684		10,216

Loss on early extinguishment of debt						Loss on early extinguishment of debt	8,071		0
Loss on disposal and impairment of fixed assets	Loss on disposal and impairment of fixed assets	22		157		Loss on disposal and impairment of fixed assets	22		998
Stock-based compensation	Stock-based compensation	18,070		15,217		Stock-based compensation	29,024		24,461
Changes in contingent consideration		(2,312)		—
Gain on investment		(8)		—
Changes in contingent consideration (after MyoScience, Inc. acquisition)						Changes in contingent consideration (after MyoScience, Inc. acquisition)	(1,560)		7,327
(Gain) loss on investment and other non-operating income, net						(Gain) loss on investment and other non-operating income, net	(2,779)		3,957
Changes in operating assets and liabilities (net of MyoScience, Inc. acquisition):	Changes in operating assets and liabilities (net of MyoScience, Inc. acquisition):					Changes in operating assets and liabilities (net of MyoScience, Inc. acquisition):
Accounts receivable, net	Accounts receivable, net	3,517		(2,141)		Accounts receivable, net	1,386		(3,567)
Inventories, net	Inventories, net	(8,394)		(2,519)		Inventories, net	(10,246)		(9,967)
Prepaid expenses and other assets	Prepaid expenses and other assets	(1,701)		(1,163)		Prepaid expenses and other assets	(382)		(2,451)
Accounts payable	Accounts payable	(3,517)		(1,321)		Accounts payable	(1,117)		829
Accrued expenses and income taxes payable	Accrued expenses and income taxes payable	(21,468)		1,844		Accrued expenses and income taxes payable	(16,454)		4,004
Other liabilities	Other liabilities	(3,052)		(245)		Other liabilities	(1,670)		(822)
Payment of contingent consideration to MyoScience, Inc. securityholders	Payment of contingent consideration to MyoScience, Inc. securityholders	(9,409)		—		Payment of contingent consideration to MyoScience, Inc. securityholders	(9,409)		0
Net cash (used in) provided by operating activities		(9,416)		26,262
Net cash provided by operating activities						Net cash provided by operating activities	30,365		44,616
Investing activities:	Investing activities:					Investing activities:
Acquisition of MyoScience, Inc. (net of cash acquired)	Acquisition of MyoScience, Inc. (net of cash acquired)	—		(118,683)		Acquisition of MyoScience, Inc. (net of cash acquired)	0		(118,683)
Purchases of fixed assets	Purchases of fixed assets	(15,630)		(4,070)		Purchases of fixed assets	(23,393)		(5,662)
Purchases of investments	Purchases of investments	(72,263)		(141,960)		Purchases of investments	(326,664)		(220,091)
Sales of investments	Sales of investments	95,450		163,017		Sales of investments	154,767		248,365

Equity Investment		—		(1,622)
Net cash provided by (used in) investing activities		7,557		(103,318)
Equity investment						Equity investment	0		(1,622)
Net cash used in investing activities						Net cash used in investing activities	(195,290)		(97,693)
Financing activities:	Financing activities:					Financing activities:
Proceeds from exercises of stock options	Proceeds from exercises of stock options	6,353		3,568		Proceeds from exercises of stock options	35,980		4,991
Proceeds from shares issued under employee stock purchase plan	Proceeds from shares issued under employee stock purchase plan	1,421		1,270		Proceeds from shares issued under employee stock purchase plan	1,421		1,270

Proceeds from debt component of the 2025 convertible senior notes						Proceeds from debt component of the 2025 convertible senior notes	314,708		0
Proceeds from equity component of the 2025 convertible senior notes						Proceeds from equity component of the 2025 convertible senior notes	87,792		0
Repayment of 2019 convertible senior notes	Repayment of 2019 convertible senior notes	—		(338)		Repayment of 2019 convertible senior notes	0		(338)
Conversion premium on 2019 convertible senior notes		—		(233)

Payment of contingent consideration to MyoScience, Inc securityholders		(5,591)		—
Repayment of 2022 convertible senior notes						Repayment of 2022 convertible senior notes	(176,793)		0
Retirement of equity component of the 2022 convertible senior notes						Retirement of equity component of the 2022 convertible senior notes	(33,089)		0
Conversion premium on the 2019 convertible senior notes						Conversion premium on the 2019 convertible senior notes	0		(233)
Payment of debt issuance and financing costs						Payment of debt issuance and financing costs	(12,487)		0
Payment of contingent consideration to MyoScience, Inc. securityholders						Payment of contingent consideration to MyoScience, Inc. securityholders	(5,591)		0
Net cash provided by financing activities	Net cash provided by financing activities	2,183		4,267		Net cash provided by financing activities	211,941		5,690
Net increase (decrease) in cash and cash equivalents	Net increase (decrease) in cash and cash equivalents	324		(72,789)		Net increase (decrease) in cash and cash equivalents	47,016		(47,387)
Cash and cash equivalents, beginning of period	Cash and cash equivalents, beginning of period	78,228		132,526		Cash and cash equivalents, beginning of period	78,228		132,526
Cash and cash equivalents, end of period	Cash and cash equivalents, end of period	$	78,552	$	59,737	Cash and cash equivalents, end of period	$	125,244	$	85,139
Supplemental cash flow information:
Cash paid for interest		$	4,097	$	4,102
Cash paid for income taxes, net of refunds		$	80	$	490
Non-cash investing and financing activities:

Net increase in contingent consideration liabilities		$	—	$	28,470
Net decrease in accrued fixed assets		$	(1,115)	$	(682)

See accompanying condensed notes to consolidated financial statements.						See accompanying condensed notes to consolidated financial statements.

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PACIRA BIOSCIENCES, INC. CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED) (In thousands) (Unaudited)
	Nine Months Ended September 30,
	2020		2019
Supplemental cash flow information:
Cash paid for interest	$	5,305	$	4,102
Cash paid for income taxes, net of refunds	$	2,329	$	702
Non-cash investing and financing activities:



Net increase in contingent consideration liabilities	$	0	$	28,470
Net increase in accrued fixed assets	$	6,423	$	1,663

See accompanying condensed notes to consolidated financial statements.

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PACIRA BIOSCIENCES, INC.

CONDENSED NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

NOTE 1—DESCRIPTION OF BUSINESS

Pacira BioSciences, Inc. and its subsidiaries (collectively, the “Company” or “Pacira”) is athe leading provider of non-opioid pain management ~~and regenerative health~~ solutions to advance and improve outcomes for health care practitioners and their patients. The Company’s long-acting, local analgesic, EXPAREL^® (bupivacaine liposome injectable suspension), was commercially launched in the United States in April 2012. EXPAREL utilizes DepoFoam^®, a unique and proprietary delivery technology that encapsulates drugs without altering their molecular structure, and releases them over a desired period of time. In April 2019, the Company added iovera°^® to its commercial offering with the acquisition of MyoScience, Inc., or MyoScience. The iovera° system is a handheld cryoanalgesia device used to deliver a precise, controlled application of cold temperature to only targeted nerves.

Pacira is subject to risks common to companies in similar industries and stages, including, but not limited to, competition from larger companies, reliance on revenue from 2 products, reliance on a limited number of manufacturing sites, new technological innovations, dependence on key personnel, reliance on third-party service providers and sole source suppliers, protection of proprietary technology, compliance with government regulations and risks related to cybersecurity. For information on the Company’s risks related to the ongoing worldwide novel coronavirus (COVID-19) pandemic, see Part II, Item 1A. “Risk Factors”, included in this Quarterly Report on Form 10-Q.

The Company is managed and operated as a single business focused on the ~~discovery,~~ development, manufacture, marketing, distribution and sale of non-opioid pain management and regenerative health solutions. The Company is managed by a single management team, and consistent with its organizational structure, the Chief Executive Officer and Chairman manages and allocates resources at a consolidated level. Accordingly, the Company views its business as 1 reportable segment to evaluate performance, allocate resources, set operational targets and forecast its future financial results.

Novel Coronavirus (COVID-19) Pandemic

During ~~the second quarter of~~ 2020, the Company’s net product sales were negatively impacted by the global pandemic caused by a novel strain of coronavirus (COVID-19), which mandated significant postponement or suspension in the scheduling of elective surgical procedures resulting from public health guidance and government directives. Elective surgery restrictions began to lift on a state-by-state basis in April 2020; however, the Company does not know ~~how long other states will mandate stay at home orders,~~ how long it will take the surgical community to return to normal operations or if states will return to placing restrictions on elective surgical procedures. The Company’s manufacturing sites are operational and have implemented new safety protocols and guidelines as recommended by federal, state and local governments. To date, there have been no material impacts to the Company’s supply chain. The situation remains dynamic and subject to rapid and possibly material changes. Additional negative impacts may also arise from the COVID-19 pandemic that the Company is unable to foresee. The nature and extent of such impacts will depend on future developments, which are highly uncertain and cannot be predicted.

NOTE 2—SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation and Principles of Consolidation

These interim condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America, or GAAP, and in accordance with the rules and regulations of the United States Securities and Exchange Commission (SEC), for interim reporting. Pursuant to these rules and regulations, certain information and footnote disclosures normally included in complete annual financial statements have been condensed or omitted. Therefore, these interim condensed consolidated financial statements should be read in conjunction with the audited annual consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2019.

The condensed consolidated financial statements at ~~June~~September 30, 2020, and for the three and ~~six-month~~nine-month periods ended ~~June~~September 30, 2020 and 2019, are unaudited, but include all adjustments (consisting of only normal recurring adjustments) which, in the opinion of management, are necessary to present fairly the financial information set forth herein in accordance with GAAP. The condensed consolidated balance sheet at December 31, 2019 is derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2019. The condensed consolidated financial statements as presented reflect certain reclassifications from previously issued financial ~~statements to conform to the~~

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statements to conform to the current year presentation. The accounts of wholly-owned subsidiaries are included in the condensed consolidated financial statements. Intercompany accounts and transactions have been eliminated in consolidation.

The results of operations for these interim periods are not necessarily indicative of results that may be expected for any other interim periods or for the full year.

Concentration of Major Customers

The Company sells EXPAREL through a drop-ship program under which orders are processed through wholesalers (including AmerisourceBergen Health Corporation, Cardinal Health, Inc. and McKesson Drug Company), but shipments of the product are sent directly to individual accounts, such as hospitals, ambulatory surgery centers and individual doctors. The Company also sells EXPAREL directly to ambulatory surgery centers and physicians. The Company sells its bupivacaine liposome injectable suspension for veterinary use to a third-party licensee and sells iovera° directly to end users. The table below includes the percentage of revenues comprised by the Company’s 3 largest wholesalers in each period presented:


		Three Months Ended June 30,			Six Months Ended June 30,				Three Months Ended September 30,		Nine Months Ended September 30,
		2020	2019	2020	2019		2020	2019	2020	2019
Largest wholesaler	Largest wholesaler	32%	32%	31%	34%	Largest wholesaler	31%	34%	31%	34%
Second largest wholesaler	Second largest wholesaler	30%	29%	31%	29%	Second largest wholesaler	30%	29%	31%	29%
Third largest wholesaler	Third largest wholesaler	24%	26%	25%	26%	Third largest wholesaler	25%	27%	25%	26%
Total	Total	86%	87%	87%	89%	Total	86%	90%	87%	89%

Recently Adopted Accounting Pronouncements

In February 2016, the Financial Accounting Standards Board, or FASB, issued Accounting Standards Update, or ASU, 2016-02, Leases (Topic 842), which was adopted by the Company on January 1, 2019 using the effective date method. ~~At adoption, the~~The Company recorded $36.5 million of lease liabilities and $27.6 million of right-of-use, or ROU, assets as of January 1, 2019, the difference representing previously recorded lease-related assets and liabilities. There was a cumulative-effect adjustment to retained earnings of $0.2 million upon adoption.

In June 2016, the FASB issued ASU 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments, which requires entities to measure all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions and reasonable and supportable forecasts. The Company now includes forward-looking information to better form its credit loss estimates. This update also required enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity’s portfolio. This standard became effective for the Company beginning January 1, ~~2020. There~~2020 and there were 0 credit losses recognized upon ~~adoption at January 1, 2020.~~adoption.

In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework. The update added the following disclosures: (i) changes in unrealized gains and losses for the period included in other comprehensive income (loss) for recurring Level 3 fair value measurements held at the end of the reporting period and (ii) the range and weighted average of significant unobservable inputs used to develop Level 3 fair value measurements. The standard became effective for the Company beginning January 1, 2020 and the Company has applied these new disclosure requirements in its condensed consolidated financial statements as of and for the three and ~~six~~nine months ended ~~June~~September 30, 2020.

In August 2018, the FASB issued ASU 2018-15, Intangibles—Goodwill and Other Internal-Use Software (Subtopic 350-40): Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That is a Service Contract, which aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software. The update provides guidance to determine which implementation costs to capitalize as they relate to the service contract and which costs to expense. Any expense related to the capitalized implementation costs should be recorded in the same financial statement line item in the consolidated statements of operations as the fees associated with the hosting element of the arrangement, and the payments for capitalized implementation costs should be classified in the same manner as payments made for fees associated with the hosting element in the consolidated statements of cash flows. This standard became effective for the Company beginning January 1, 2020. The amendments are to be applied prospectively to all implementation costs incurred

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after the date of adoption. The Company did not incur any implementation costs in a hosting arrangement during the three and ~~six~~nine months ended ~~June~~September 30, 2020.

Recent Accounting Pronouncements Not Adopted as of ~~June~~September 30, 2020

In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740), Simplifying the Accounting for Income Taxes, which amends the approaches and methodologies in accounting for income taxes during interim periods and makes changes to certain income tax classifications. The new standard allows certain exceptions, including an exception to the use of the incremental approach for intra-period tax ~~allocation,~~allocations, when there is a loss from continuing operations and income or a gain from other items, and to the general methodology for calculating income taxes in an interim period, when a year-to-date loss exceeds the anticipated loss for the year. The standard also requires franchise or similar taxes partially based on income to be reported as income tax and to reflect the effects of enacted changes in tax laws or rates in the annual effective tax rate computation from the date of enactment. Lastly, in any future acquisition, the Company would be required to evaluate when the step-up in the tax basis of goodwill is part of the business combination and when it should be considered a separate transaction. The standard will be effective for the Company beginning January 1, 2021, with early adoption of the amendments permitted. The Company is evaluating the impact from the adoption of ASU 2019-12 on its consolidated financial statements.

In August 2020, the FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40), which limits the number of convertible instruments that require separate accounting to (i) those with embedded conversion features that are not clearly and closely related to the debt, that meet the definition of a derivative, and that do not qualify for the scope exception from derivative accounting and (ii) convertible debt instruments issued with substantial premiums for which the premiums are recorded as paid-in capital. In addition, the new guidance requires diluted EPS calculations to be prepared using the if-converted method, instead of the treasury stock method. The guidance must be applied in fiscal years beginning after December 15, 2021, including interim periods within those fiscal years, with early adoption permitted no earlier than for fiscal years beginning after December 15, 2020. The Company has the option to adopt the new guidance using a modified retrospective method of transition, which would then be applied to transactions outstanding at the time of adoption, or the full retrospective method. The Company is evaluating the impact from the adoption of ASU 2020-06 on its consolidated financial statements.

NOTE 3—REVENUE

Revenue from Contracts with Customers

The Company’s sources of revenue include (i) sales of EXPAREL in the U.S.; (ii) sales of iovera° in the U.S.; (iii) sales of, and royalties on, its bupivacaine liposome injectable suspension for veterinary use in the U.S. and (iv) license fees and milestone payments. The Company does not consider revenue from sources other than sales of EXPAREL to be material sources of its consolidated revenue. As such, the following disclosure only relates to revenue associated with net EXPAREL product sales.

Net Product Sales

The Company sells EXPAREL through a drop-ship program under which orders are processed through wholesalers based on orders of the product placed by end-users, namely hospitals, ambulatory surgery centers and healthcare provider offices. EXPAREL is delivered directly to the end-user without the wholesaler ever taking physical possession of the product. Product revenue is recognized when control of the promised goods are transferred to the customers, in an amount that reflects the consideration the Company expects to be entitled to in exchange for transferring those goods. EXPAREL revenue is recorded at the time the product is delivered to the end-user.

Revenues from sales of products are recorded net of returns allowances, prompt payment discounts, wholesaler service fees, volume rebates and chargebacks. These reserves are based on estimates of the amounts earned or to be claimed on the related sales. These amounts are treated as variable consideration, estimated and recognized as a reduction of the transaction price at the time of the sale, using the most likely amount method for the gross to net adjustments, except for returns, which is based on the expected value method. The Company includes these estimated amounts in the transaction price to the extent it is probable that a significant reversal of cumulative revenue recognized for such transaction will not occur, or when the uncertainty associated with the variable consideration is resolved. The calculation of some of these items requires management to make estimates based on sales data, historical return data, contracts and other related information that may become known in the future. The adequacy of these provisions is reviewed on a quarterly basis.

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Accounts Receivable

The majority of accounts receivable arise from product sales and represent amounts due from wholesalers, hospitals, ambulatory surgery centers and doctors. Payment terms generally range from zero to 37 days from the date of the transaction, and accordingly, there is no significant financing component.

Performance Obligations

A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account in Accounting Standards Codification (ASC) 606. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied.

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At contract inception, the Company assesses the goods promised in its contracts with customers and identifies a performance obligation for each promise to transfer to the customer a good that is distinct. When identifying individual performance obligations, the Company considers all goods promised in the contract regardless of whether explicitly stated in the customer contract or implied by customary business practices. The Company’s contracts with customers require it to transfer an individual distinct product, which represents a single performance obligation. The Company’s performance obligation with respect to its product sales is satisfied at a point in time, which transfers control upon delivery of EXPAREL to its customers. The Company considers control to have transferred upon delivery because the customer has legal title to the asset, physical possession of the asset has been transferred, the customer has significant risks and rewards of ownership of the asset and the Company has a present right to payment at that time.

Disaggregated Revenue

The following table represents disaggregated net product sales in the periods presented as follows (in thousands):


		Three Months Ended June 30,						Six Months Ended June 30,							Three Months Ended September 30,				Nine Months Ended September 30,
		2020		2019		2020		2019			2020		2019		2020		2019
Net product sales:	Net product sales:									Net product sales:
EXPAREL / bupivacaine liposome injectable suspension	EXPAREL / bupivacaine liposome injectable suspension	$	73,821	$	99,789	$	176,296	$	190,695	EXPAREL / bupivacaine liposome injectable suspension	$	114,163	$	101,711	$	290,459	$	292,406
iovera°	iovera°	1,395		2,035		3,665		2,035		iovera°	2,726		2,639		6,391		4,674
Total net product sales	Total net product sales	$	75,216	$	101,824	$	179,961	$	192,730	Total net product sales	$	116,889	$	104,350	$	296,850	$	297,080

NOTE 4—MYOSCIENCE ACQUISITION

On April 9, 2019, the Company acquired MyoScience (the “MyoScience Acquisition”), a privately-held medical device company, pursuant to the terms of an Agreement and Plan of Merger, under which MyoScience became a wholly-owned subsidiary of the Company and was renamed Pacira CryoTech, Inc. The total consideration was $147.5 million, which included a net cash payment of $119.0 million and the fair value of contingent consideration in the amount of $28.5 million. The contingent consideration consisted of contingent milestone payments up to an aggregate of $100.0 million upon the achievement of certain regulatory and commercial milestones, of which $58.0 million are available as of ~~June~~September 30, 2020. The Company’s obligation to make milestone payments is limited to those milestones achieved through December 31, 2023, and are to be paid within 60 days of the end of the fiscal quarter of achievement. During the ~~six~~nine months ended ~~June~~September 30, 2020, the Company made $15.0 million of cash payments for the achievement of two regulatory milestones. See Note 10, Financial Instruments, for information on the measurement and amounts recognized onin the Company’s condensed consolidated ~~balance sheets~~financial statements for contingent consideration. See Note 16, Commitments and Contingencies, for information on a dispute regarding the achievement of certain milestone payments.

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Unaudited Pro Forma Summary of Operations

The following table shows the unaudited pro forma summary of operations for the ~~three and six~~nine months ended ~~June~~September 30, 2019 as if the MyoScience Acquisition had occurred on January 1, 2019. This pro forma information does not purport to represent what the Company’s actual results would have been and is not indicative of what such results would be expected for any future period (in thousands, except per share amounts):

Three Months Ended June 30, 2019 Six Months Ended
June 30, 2019
Total revenues $ 102,913 $ 196,366
Net income (loss) $ 4,234 $ (4,742)
Pro forma basic and diluted net income (loss) loss per share $ 0.10 $ (0.11)


	Nine Months Ended September 30, 2019
Total revenues	$	301,051
Net loss	$	(10,633)
Pro forma basic and diluted net loss per share	$	(0.26)

The unaudited pro forma financial information was prepared using the acquisition method of accounting and was based on the historical financial information of the Company and MyoScience. The summary pro forma financial information primarily reflects the following pro forma adjustments:

•Removal of the acquisition-related transaction fees and costs, including certain stock-based compensation and other compensation expenses related to the acquisition;

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•Removal of the income tax benefit resulting from the Company decreasing its existing valuation allowance;

•Removal of ~~MyoScience's~~MyoScience’s loss on extinguishment of debt and warrant expense;

•Removal of MyoScience’s interest expense;

•Adjustments to the Company’s interest income for the cash used to acquire MyoScience; and

•The addition of amortization expense on the acquired developed technology and customer relationship intangible assets.

NOTE 5—INVENTORIES

The components of inventories, net are as follows (in thousands):


		June 30,		December 31,			September 30,		December 31,
		2020		2019			2020		2019
Raw materials	Raw materials	$	23,894	$	20,019	Raw materials	$	27,614	$	20,019
Work-in-process	Work-in-process	9,699		14,407		Work-in-process	12,080		14,407
Finished goods	Finished goods	33,097		23,870		Finished goods	28,848		23,870
Total	Total	$	66,690	$	58,296	Total	$	68,542	$	58,296

In December 2019, the Company’s contract manufacturer experienced a media fill failure, ~~which is~~as part of ~~the~~its routine aseptic manufacturing requalification program, and an investigation was completed in April 2020. Based on the results of the investigation, the Company determined that no inventory reserves are required related to the media fill failure, and that all inventory in question has been determined to be sellable. The Company resumed production on this manufacturing line in May 2020.

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NOTE 6—FIXED ASSETS

Fixed assets, net, summarized by major category, consist of the following (in thousands):


		June 30,		December 31,			September 30,		December 31,
		2020		2019			2020		2019
Machinery and equipment	Machinery and equipment	$	74,436	$	70,078	Machinery and equipment	$	75,489	$	70,078
Leasehold improvements	Leasehold improvements	60,856		60,441		Leasehold improvements	60,915		60,441
Computer equipment and software	Computer equipment and software	10,608		8,942		Computer equipment and software	11,178		8,942
Office furniture and equipment	Office furniture and equipment	2,003		1,882		Office furniture and equipment	2,242		1,882
Construction in progress	Construction in progress	46,611		38,778		Construction in progress	59,990		38,778
Total	Total	194,514		180,121		Total	209,814		180,121
Less: accumulated depreciation	Less: accumulated depreciation	(81,217)		(75,440)		Less: accumulated depreciation	(84,287)		(75,440)
Fixed assets, net	Fixed assets, net	$	113,297	$	104,681	Fixed assets, net	$	125,527	$	104,681

For the three months ended ~~June~~September 30, 2020 and 2019, depreciation expense was ~~$3.0~~$3.1 million and ~~$3.5~~$3.6 million, respectively. For the three months ended ~~June~~September 30, 2020 and 2019, there was $0.7 million and 0less than $0.1 million of capitalized interest on the construction of manufacturing sites, respectively.

For the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019, depreciation expense was ~~$5.9~~$8.9 million and ~~$7.1~~$10.7 million, respectively. For the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019, there was ~~$0.8~~$1.5 million and 0less than $0.1 million of capitalized interest on the construction of manufacturing sites, respectively.

At ~~June~~September 30, 2020 and December 31, 2019, total fixed assets, net, includes leasehold improvements and manufacturing process equipment located in Europe in the amount of ~~$65.4~~$66.8 million and $64.8 million, respectively.

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During the ~~six~~nine months ended ~~June~~September 30, 2020, the Company established an asset retirement obligation of $0.2 million related to a new building lease which contains manufacturing, research and development and office space at its Science Center Campus in San Diego, California.

NOTE 7—LEASES

The Company leases all of its facilities, including its EXPAREL manufacturing facility in San Diego, California and its iovera° manufacturing facility in Fremont, California. These leases have remaining terms up to ~~10.2~~9.9 years, some of which provide renewal options at the then-current market value. The Company also has a lease with Thermo Fisher Scientific Pharma Services, or Thermo Fisher (formerly Patheon UK Limited), for the use of their manufacturing facility in Swindon, England, which is embedded in agreements the Company has with Thermo Fisher. A portion of the associated monthly base fees has been allocated to the lease component based on a relative fair value basis.

The operating lease costs for the facilities include lease and non-lease components, such as common area maintenance and other common operating expenses, along with executory costs such as insurance and real estate taxes. Total operating lease costs are as follows (in thousands):


		Three Months Ended						Six Months Ended							Three Months Ended				Nine Months Ended
		June 30,						June 30,							September 30,				September 30,
Operating Lease Costs	Operating Lease Costs	2020		2019		2020		2019		Operating Lease Costs	2020		2019		2020		2019
Fixed lease costs	Fixed lease costs	$	2,422	$	1,516	$	3,986	$	2,959	Fixed lease costs	$	3,099	$	1,585	$	7,085	$	4,544
Variable lease costs	Variable lease costs	601		449		1,049		829		Variable lease costs	611		403		1,661		1,233
Total	Total	$	3,023	$	1,965	$	5,035	$	3,788	Total	$	3,710	$	1,988	$	8,746	$	5,777

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Supplemental cash flow information related to operating leases is as follows (in thousands):

Six Months Ended
June 30,
2020 2019
Cash paid for operating lease liabilities $ 8,503 $ 3,121
Right-of-use assets recorded in exchange for lease obligations $ 42,101 $ 38,419


	Nine Months Ended
	September 30,
	2020		2019
Cash paid for lease ROU assets and liabilities	$	11,251	$	5,247
ROU assets recorded in exchange for lease obligations	$	42,101	$	38,419

The Company has elected to net the amortization of the ROU asset and the reduction of the lease liability principal in accrued expenses in the condensed consolidated statement of cash flows.

The Company has measured its operating lease liabilities at an estimated discount rate in which it could borrow on a collateralized basis over the remaining term for each operating lease. The weighted average remaining lease term and the weighted average discount rate are summarized as follows:


						~~June~~September 30, 2020
Weighted average remaining lease term						~~9.55~~9.39 years
Weighted average discount rate						6.88%

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Maturities of the Company’s operating lease liabilities are as follows (in thousands):


Year	Year	Aggregate Minimum Payments Due		Year	Aggregate Minimum Payments Due
2020 (remaining six months)		$	7,497
2020 (remaining three months)				2020 (remaining three months)	$	4,501
2021	2021	10,745		2021	10,745
2022	2022	10,423		2022	10,423
2023	2023	10,697		2023	10,697
2024	2024	10,980		2024	10,980
2025 through 2030	2025 through 2030	62,072		2025 through 2030	62,072
Total lease payments	Total lease payments	112,414		Total lease payments	109,418

Less: imputed interest	Less: imputed interest	(30,906)		Less: imputed interest	(29,515)
Total operating lease liabilities	Total operating lease liabilities	$	81,508	Total operating lease liabilities	$	79,903

NOTE 8—GOODWILL AND INTANGIBLE ASSETS

Goodwill

There was no0 change in the carrying value of the Company’s goodwill during the three and ~~six~~nine months ended ~~June~~September 30, 2020. The balance at both September 30, 2020 and December 31, 2019 ~~and June 30, 2020~~ was $99.5 million.

Skyepharma Acquisition

In March 2007, the Company acquired from SkyePharma Holding, Inc. (now a subsidiary of Vectura Group plc), or Skyepharma, its California operating subsidiary named Pacira Pharmaceuticals, Inc. (the “Skyepharma Acquisition”). The Skyepharma Acquisition was accounted for under Statement of Financial Accounting Standards 141, Accounting for Business Combinations, which was the effective GAAP standard at the Skyepharma Acquisition date. As of ~~June~~September 30, 2020, the Company has recorded $62.0 million of goodwill related to the Skyepharma Acquisition.

In connection with the Skyepharma Acquisition, the Company agreed to percentage and milestone payments for DepoBupivacaine products, including EXPAREL. The milestone payments are as follows:

(i) $10.0 million upon the first commercial sale in the United States (met April 2012);

(ii) $4.0 million upon the first commercial sale in the United Kingdom, France, Germany, Italy or Spain;

(iii) $8.0 million when annual net sales collected reach $100.0 million (met September 2014);

(iv) $8.0 million when annual net sales collected reach $250.0 million (met June 2016); and

(v) $32.0 million when annual net sales collected reach $500.0 million.

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The two unmet milestone payments totaling $36.0 million are the only remaining obligations to Skyepharma. Any remaining milestone payments will be treated as additional costs of the Skyepharma Acquisition and, therefore, recorded as goodwill if and when each contingency is resolved. For purposes of meeting future potential milestone payments, annual net sales are measured on a rolling quarterly basis.

MyoScience Acquisition

In connection with the MyoScience Acquisition, the Company recorded goodwill totaling $37.5 million. The Company subsequently made a tax election that allows the acquired goodwill and intangible assets to be tax deductible.

Intangible Assets

MyoScience Acquisition

Intangible assets, net, consist of the developed technology and customer relationships that were acquired in the MyoScience Acquisition and are summarized as follows (in thousands):

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June 30, 2020		Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Estimated Useful Life
September 30, 2020									September 30, 2020	Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Estimated Useful Life
Developed technology	Developed technology	$	110,000	$	(9,625)	$	100,375	14 years	Developed technology	$	110,000	$	(11,590)	$	98,410	14 years
Customer relationships	Customer relationships	90		(11)		79		10 years	Customer relationships	90		(13)		77		10 years
Total intangible assets	Total intangible assets	$	110,090	$	(9,636)	$	100,454		Total intangible assets	$	110,090	$	(11,603)	$	98,487


December 31, 2019	Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Estimated Useful Life
Developed technology	$	110,000	$	(5,696)	$	104,304	14 years
Customer relationships	90		(7)		83		10 years
Total intangible assets	$	110,090	$	(5,703)	$	104,387

Amortization expense on intangible assets for the three and ~~six~~nine months ended ~~June~~September 30, 2020 was $2.0 million and ~~$3.9~~$5.9 million, respectively. There was ~~$1.8~~$2.0 million and $3.7 million of amortization expense on intangible assets for ~~both~~ the three and ~~six~~nine months ended ~~June~~September 30, ~~2019.~~2019, respectively.

Assuming no changes in the gross carrying amount of these intangible assets, amortization expense on intangible assets will be ~~$3.9~~$2.0 million for the remaining ~~six~~three months of 2020 and the future amortization expense on intangible assets will be $7.9 million annually through 2032 and $2.2 million in 2033.

NOTE 9—DEBT

Convertible Senior Notes Due 2025

On July 10, 2020, the Company completed a private placement of $402.5 million in aggregate principal amount of ~~0.75%~~its 0.750% convertible senior notes due 2025, or 2025 Notes, and entered into an indenture, or 2025 Indenture, with respect to the 2025 Notes. The 2025 Notes accrue interest at a fixed rate of ~~0.75%~~0.750% per year, payable semiannually in arrears on February 1^st and August 1^st of each year, beginning on February 1, 2021. The 2025 Notes mature on August 1, 2025.

The ~~Company used part~~total debt composition of the 2025 Notes is as follows (in thousands):


	September 30,		December 31,
	2020		2019
0.750% convertible senior notes due 2025	$	402,500	$	0
Deferred financing costs	(9,373)		0
Discount on debt	(84,346)		0
Total debt, net of debt discount and deferred financing costs	$	308,781	$	0

The net proceeds from the issuance of the 2025 Notes were approximately $390.0 million, after deducting commissions and the offering expenses by the Company. A portion of the net proceeds from the 2025 Notes were used by the Company to

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repurchase $185.0 million in aggregate principal amount of ~~the~~its outstanding 2.375% convertible senior notes due 2022 ~~Notes~~ in privately-negotiated transactions for ~~an aggregate~~a total of ~~approximately~~ $211.1 million inof cash (including accrued interest).

Holders may convert the 2025 Notes at any time prior to the close of business on the business day immediately preceding February 3, 2025, only under the following circumstances:

(i) during any calendar quarter commencing after the calendar quarter ending on September 30, 2020 (and only during such calendar quarter), if the last reported sale price of the Company’s common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;

(ii) during the five business day period immediately after any five consecutive trading day period (the ‘‘measurement period’’) in which the trading price (as defined in the 2025 Indenture) per $1,000 principal amount of notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day;

(iii) upon the occurrence of specified corporate events, including a merger or a sale of all or substantially all of the Company’s assets; or

(iv) if the Company calls the 2025 Notes for redemption, until the close of business on the business day immediately preceding the redemption date.

During the quarter ended September 30, 2020, none of these conditions for conversion were met.

On or after February 3, 2025, until the close of business on the second scheduled trading day immediately preceding August 1, 2025, holders may convert their 2025 Notes at any time.

Upon conversion, holders will receive the principal amount of their 2025 Notes and any excess conversion value, calculated based on the per share volume-weighted average price for each of the 40 consecutive trading days during the observation period (as more fully described in the 2025 Indenture). For ~~more~~both the principal and excess conversion value, holders may receive cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s option. The initial conversion rate for the 2025 Notes is 13.9324 shares of common stock per $1,000 principal amount, which is equivalent to an initial conversion price of $71.78 per share of the Company’s common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. The initial conversion price of the 2025 Notes represents a premium of approximately 32.5% to the closing sale price of $54.17 per share of the Company’s common stock on the Nasdaq Global Select Market on July 7, 2020, the date that the Company priced the private offering of the 2025 Notes.

As of September 30, 2020, the 2025 Notes had a market price of $1,096 per $1,000 principal amount. In the event of conversion, holders would forgo all future interest payments, any unpaid accrued interest and the possibility of further stock price appreciation. Upon the receipt of conversion requests, the settlement of the 2025 Notes will be paid pursuant to the terms of the 2025 Indenture. In the event that all of the 2025 Notes are converted, the Company would be required to repay the $402.5 million in principal value and any conversion premium in any combination of cash and shares of its common stock (at the Company’s option).

Prior to August 1, 2023, the Company may not redeem the 2025 Notes. On or after August 1, 2023 (but, in the case of a redemption of less than all of the outstanding 2025 Notes, no later than the 40th scheduled trading day immediately before the maturity date), the Company may redeem for cash all or part of the 2025 Notes if the last reported sale price (as defined in the 2025 Indenture) of the Company’s common stock has been at least 130% of the conversion price then in effect for (i) each of at least 20 trading days (whether or not consecutive) during any 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related notice of redemption and (ii) the trading day immediately before the date the Company sends such notice. The redemption price will equal the sum of (i) 100% of the principal amount of the 2025 Notes being redeemed, plus (ii) accrued and unpaid interest, including additional interest, if any, to, but excluding, the redemption date. In addition, calling the 2025 Notes for redemption will constitute a “make-whole fundamental change ” (as defined in the 2025 Indenture) and will, in certain circumstances, increase the conversion rate applicable to the conversion of such notes if it is converted in connection with the redemption. No sinking fund is provided for the 2025 Notes.

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100% of the principal amount of the 2025 Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. In addition, if a ‘‘make-whole fundamental change’’ (as defined in the 2025 Indenture) occurs prior to August 1, 2025, the Company will, in certain circumstances, increase the conversion rate for a holder who elects to convert its notes in connection with the make-whole fundamental change.

The 2025 Notes are the Company’s general unsecured obligations that rank senior in right of payment to all of its indebtedness that is expressly subordinated in right of payment to the 2025 Notes, and equal in right of payment to the Company’s unsecured indebtedness. The 2025 Notes are also effectively junior in right of payment to any of the Company’s secured indebtedness to the extent of the value of the assets securing such indebtedness, and are structurally subordinated to any debt or other liabilities (including trade payables) of the Company’s subsidiaries.

While the 2025 Notes are currently classified on the Company��s consolidated balance sheet at September 30, 2020 as long-term debt, the future convertibility and resulting balance sheet classification of this liability is monitored at each quarterly reporting date and is analyzed dependent upon market prices of the Company’s common stock during the prescribed measurement periods. In the event that the holders of the 2025 Notes have the election to convert the 2025 Notes at any time during the prescribed measurement period, the 2025 Notes would then be considered a current obligation and classified as such.

Under ASC 470-20, Debt with Conversion and Other Options, an entity must separately account for the liability and equity components of convertible debt instruments (such as the 2025 Notes) that may be settled entirely or partially in cash upon conversion in a manner that reflects the issuer’s economic interest cost. The liability component of the instrument is valued in a manner that reflects the market interest rate for a similar nonconvertible instrument at the date of issuance. The initial carrying value of the liability component of $314.7 million was calculated using a 5.78% assumed borrowing rate. The equity component of $87.8 million, representing the conversion option, was determined by deducting the fair value of the liability component from the par value of the 2025 Notes and is recorded in additional paid-in capital on the consolidated balance sheet at the issuance date. The equity component is treated as a discount on the liability component of the 2025 Notes, which is amortized over the five-year term of the 2025 Notes using the effective interest rate method. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. A deferred tax liability was recognized in the amount of $20.5 million, with the offsetting amount recorded in additional paid-in capital. See Note 14, Income Taxes, for information regarding the Company's deferred taxes.

The Company allocated the total transaction costs of approximately $12.5 million related to the issuance of the 2025 Notes to the liability and equity components of the 2025 Notes based on their relative values. Transaction costs attributable to the liability component are amortized to interest expense over the five-year term of the 2025 Notes, and transaction costs attributable to the equity component totaling $2.7 million are netted with the equity component in stockholders’ equity.

The 2025 Notes do not contain any financial or operating covenants or any restrictions on the payment of dividends, the issuance of other indebtedness or the issuance or repurchase of securities by the Company. The 2025 Indenture contains customary events of default with respect to the 2025 Notes, including that upon certain events of default, 100% of the principal and accrued and unpaid interest on the 2025 Notes ~~see Note 17,~~ ~~Subsequent Events~~.will automatically become due and payable.

Convertible Senior Notes Due 2022

On March 13, 2017, the Company completed a private placement of $345.0 million in aggregate principal amount of 2.375% convertible senior notes due 2022, or 2022 Notes, and entered into an indenture, or 2022 Indenture, with respect to the 2022 Notes. The 2022 Notes accrue interest at a fixed rate of 2.375% per year, payable semiannually in arrears on April 1^st and October 1^st of each year. The 2022 Notes mature on April 1, 2022. As discussed above, in July 2020, the Company used part of the net proceeds from the issuance of the 2025 Notes to repurchase $185.0 million aggregate principal amount of the 2022 Notes in privately-negotiated transactions for an aggregate of $211.1 million in cash (including accrued interest). The partial repurchase of the 2022 Notes resulted in an $8.1 million loss on early extinguishment of debt.

The total debt composition of the 2022 Notes is as follows (in thousands):


		June 30,		December 31,			September 30,		December 31,
		2020		2019			2020		2019
2.375% convertible senior notes due 2022	2.375% convertible senior notes due 2022	$	345,000	$	345,000	2.375% convertible senior notes due 2022	$	160,000	$	345,000
Deferred financing costs	Deferred financing costs	(3,260)		(4,143)		Deferred financing costs	(1,299)		(4,143)
Discount on debt	Discount on debt	(27,558)		(34,812)		Discount on debt	(11,018)		(34,812)
Total debt, net of debt discount and deferred financing costs	Total debt, net of debt discount and deferred financing costs	$	314,182	$	306,045	Total debt, net of debt discount and deferred financing costs	$	147,683	$	306,045

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Holders may convert their 2022 Notes prior to October 1, 2021 only if certain circumstances are met, including if during the previous calendar quarter, the last reported sales price of the Company’s common stock was greater than or equal to 130% of the conversion price then applicable for at least 20 out of the last 30 consecutive trading days of the quarter. During the quarter ended ~~June~~September 30, 2020, this condition for conversion was not met.

On or after October 1, 2021, until the close of business on the second scheduled trading day immediately preceding April 1, 2022, holders may convert their 2022 Notes at any time.

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Upon conversion, holders will receive the principal amount of their 2022 Notes and any excess conversion value, calculated based on the per share volume-weighted average price for each of the 40 consecutive trading days during the observation period (as more fully described in the 2022 Indenture). For both the principal and excess conversion value, holders may receive cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s option. The initial conversion rate for the 2022 Notes is 14.9491 shares of common stock per $1,000 principal amount, which is equivalent to an initial conversion price of $66.89 per share of the Company’s common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. The initial conversion price of the 2022 Notes represents a premium of approximately 37.5% to the closing sale price of $48.65 per share of the Company’s common stock on the Nasdaq Global Select Market on March 7, 2017, the date that the Company priced the private offering of the 2022 Notes.

As of ~~June~~September 30, 2020, the 2022 Notes had a market price of ~~$1,096~~$1,149 per $1,000 principal amount. In the event of conversion, holders would forgo all future interest payments, any unpaid accrued interest and the possibility of stock price appreciation. Upon the receipt of conversion requests, the settlement of the 2022 Notes will be paid pursuant to the terms of the 2022 Indenture. In the event that all of the 2022 Notes are settled, the Company would be required to repay the ~~$345.0~~remaining $160.0 million in principal value ~~($160.0 million following the July 2020 repurchase of $185.0 million aggregate principal of 2022 Notes discussed above and in Note 17,~~ a~~Subsequent Events) and~~nd any conversion premium in any combination of cash and shares of its common stock (at the Company’s option).

As of April 1, 2020, the Company may redeem for cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s option, all or part of the 2022 Notes if the last reported sale price (as defined in the 2022 Indenture) of the Company’s common stock has been at least 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading-day period ending within five trading days prior to the date on which the Company provides notice of redemption. This condition was not met during the quarter ended ~~June~~September 30, 2020. The redemption price will equal the sum of (i) 100% of the principal amount of the 2022 Notes being redeemed, plus (ii) accrued and unpaid interest, including additional interest, if any, to, but excluding, the redemption date. In addition, calling the 2022 Notes for redemption will constitute a “make whole fundamental change” (as defined in the 2022 Indenture) and will, in certain circumstances, increase the conversion rate applicable to the conversion of such notes if it is converted in connection with the redemption. No sinking fund is provided for the 2022 Notes.

While the 2022 Notes are currently classified on the Company’s consolidated balance sheet at ~~June~~September 30, 2020 as long-term debt, the future convertibility and resulting balance sheet classification of this liability is monitored at each quarterly reporting date and is analyzed dependent upon market prices of the Company’s common stock during the prescribed measurement periods. In the event that the holders of the 2022 Notes have the right to convert the 2022 Notes at any time during the prescribed measurement period, the 2022 Notes would then be considered a current obligation and classified as such.

Interest Expense

The following table sets forth the total interest expense recognized in the periods presented (dollar amounts in thousands):

Three Months Ended
June 30, Six Months Ended
June 30,
2020 2019 2020 2019
Contractual interest expense $ 2,048 $ 2,049 $ 4,097 $ 4,098
Amortization of debt issuance costs 444 424 883 844
Amortization of debt discount 3,660 3,405 7,254 6,749
Capitalized interest and other (Note 6) (696) — (757) —
Total $ 5,456 $ 5,878 $ 11,477 $ 11,691
Effective interest rate on convertible senior notes 7.81 % 7.81 % 7.81 % 7.81 %


	Three Months Ended September 30,						Nine Months Ended September 30,
	2020			2019			2020			2019
Contractual interest expense	$	1,764		$	2,048		$	5,861		$	6,146
Amortization of debt issuance costs	629			429			1,512			1,273
Amortization of debt discount	5,430			3,467			12,684			10,216
Capitalized interest and other (Note 6)	(691)			(4)			(1,448)			(4)
Total	$	7,132		$	5,940		$	18,609		$	17,631

Effective interest rate on convertible senior notes	6.78		%	7.81		%	7.35		%	7.81		%

1720

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NOTE 10—FINANCIAL INSTRUMENTS

Fair Value Measurements

Fair value is defined as the price that would be received to sell an asset or be paid to transfer a liability in the principal or most advantageous market in an orderly transaction. To increase consistency and comparability in fair value measurements, the FASB established a three-level hierarchy which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The three levels of fair value measurements are:

•Level 1—Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.

•Level 2—Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.

•Level 3—Unobservable inputs that are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.

The carrying value of financial instruments including cash and cash equivalents, accounts receivable and accounts payable approximate their respective fair values due to the short-term nature of these items. The fair value of the Company’s equity investment is calculated utilizing market quotations from a major American stock exchange (Level 1). The fair value of the Company’s convertible senior notes are calculated utilizing market quotations from an over-the-counter trading market for these notes (Level 2). The fair value of the Company’s acquisition-related contingent consideration is reported at fair value on a recurring basis (Level 3). The carrying values and fair values of the Company’s financial assets and liabilities at ~~June~~September 30, 2020 are as follows (in thousands):


		Carrying Value			Fair Value Measurements Using																Carrying Value				Fair Value Measurements Using
							Level 1			Level 2			Level 3			Carrying Value			Level 1				Level 2				Level 3
Financial Assets:	Financial Assets:												Financial Assets:
Equity investment ⁽³⁾	Equity investment ⁽³⁾	$	10,032		$	10,032		$	—		$	—	Equity investment (3)	$	12,803				$	12,803			$	0			$	0
Financial Liabilities:	Financial Liabilities:												Financial Liabilities:

2.375% convertible senior notes due 2022 ⁽¹⁾	2.375% convertible senior notes due 2022 ⁽¹⁾	$	314,182	⁽²⁾	$	—		$	378,206		$	—	2.375% convertible senior notes due 2022 (1)	$	147,683	(2)	$	0			$	183,800			$	0
0.750% convertible senior notes due 2025 (1)													0.750% convertible senior notes due 2025 (1)	$	308,781	(2)	$	0			$	441,241			$	0
Acquisition-related contingent consideration ⁽³⁾	Acquisition-related contingent consideration ⁽³⁾	$	20,830		$	—		$	—		$	20,830	Acquisition-related contingent consideration (3)	$	21,582		$	0			$	0			$	21,582

(1) The closing price of the Company’s common stock as reported on the Nasdaq Global Select Market was ~~$52.47~~$60.12 per share on ~~June~~September 30, 2020 compared to a conversion price of $66.89 per ~~share.~~share for the 2022 Notes and $71.78 per share for the 2025 Notes. Therefore, at ~~June~~September 30, 2020, the conversion price was above the stock price. The maximum conversion premium that could have been due on the 2022 Notes and 2025 Notes at ~~June~~September 30, 2020 was approximately ~~5.2~~2.4 million and 5.6 million shares, respectively, of the Company’s common ~~stock, which subsequently became 2.4 million shares after the July 2020 redemption of $185 million of aggregate principal 2022 Notes (see Note 17,~~ ~~Subsequent Events, for more information).~~stock. These figures assume no increases in the conversion rate for certain corporate events.

(2) Reported at historical cost.

(3) Reported at fair value on a recurring basis.

Certain assets and liabilities are measured at fair value on a non-recurring basis, including assets and liabilities acquired in a business combination and long-lived assets, which would be recognized at fair value if deemed impaired or if reclassified as assets held for sale. The fair value in these instances would be determined using Level 3 inputs.

Financial Liabilities Measured at Fair Value on a Recurring Basis

The Company has recognized contingent consideration related to the MyoScience Acquisition in the amount of ~~$20.8~~$21.6 million as of ~~June~~September 30, 2020. Refer to Note 4, MyoScience Acquisition and Note 15, Acquisition-Related ~~(Gains)~~ Charges and Product Discontinuation, Net, for more information.

The Company’s contingent consideration obligations are recorded at their estimated fair values and are revalued each reporting period if and until the related contingencies are resolved. The Company has, in the three and nine month periods ended September 30, 2020, recognized $0.8 million of charges and $1.6 million of gains, respectively, related to contingent consideration as a result of revisions to ~~its forecasted revenues (principally due to~~ the ~~impact~~probabilities of ~~the COVID-19 pandemic), for the three and six month periods ended June 30, 2020, recognized $1.6 million of charges and $2.3 million of gains related to contingent consideration, respectively,~~regulatory milestones being met, which have been included in acquisition-related charges (gains) in the condensed consolidated statements of operations. The Company has measured the fair value of its contingent consideration using a probability-weighted discounted cash flow approach that is based on unobservable

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inputs and a Monte Carlo simulation. These inputs include, as applicable, estimated probabilities and the timing of achieving specified commercial and regulatory milestones, estimated forecasts of revenue and costs and discount rates

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used to calculate the present value of estimated future payments. Significant changes may increase or decrease the probabilities of achieving the related commercial and regulatory events, shorten or lengthen the time required to achieve such events, or increase or decrease estimated forecasts. At ~~June~~September 30, 2020, the weighted average discount rate was ~~5.96%~~6.09% and the weighted average probability of success for regulatory milestones was ~~22.4%~~25.2%. There were 0$7.3 million in changes in the fair value of contingent consideration in the three and ~~six~~nine months ended ~~June~~September 30, 2019.

The following table includes the key assumptions used in the valuation of the Company’s contingent consideration:


Assumption						Ranges Utilized as of ~~June~~September 30, 2020
Discount rates						~~5.94%~~6.04% to ~~6.03%~~6.15%
Probabilities of payment for regulatory milestones						3% to 100%
Projected years of payment for regulatory and commercial milestones						~~2020~~2021 to 2023

The maximum remaining potential payments related to the contingent consideration from the MyoScience Acquisition are $58.0 ~~million.~~million as of September 30, 2020.

The change in the Company’s contingent consideration recorded at fair value using Level 3 measurements is as follows (in thousands):


	Contingent Consideration Fair Value
Balance at December 31, 2019	$	38,142

Fair value adjustments and accretion	~~(2,312)~~(1,560)
Payments made	(15,000)
Balance at ~~June~~September 30, 2020	$	~~20,830~~21,582

Investments

Short-term investments consist of asset-backed securities collateralized by credit card receivables, investment grade commercial paper and corporate bonds with maturities greater than three months, but less than one year. Long-term investments consist of asset-backed securities collateralized by credit card receivables and corporate bonds with maturities greater than one year but less than ~~two~~three years. Net unrealized gains and losses (excluding credit losses, if any) from the Company’s short-term and long-term investments are reported in other comprehensive income (loss). At ~~June~~September 30, 2020, all of the Company’s short-term and long-term investments are classified as ~~available for sale~~available-for-sale investments and are determined to be Level 2 instruments, which are measured at fair value using standard industry models with observable inputs. The fair value of the commercial paper is measured based on a standard industry model that uses the three-month U.S. Treasury bill rate as an observable input. The fair value of the asset-backed securities and corporate bonds is principally measured or corroborated by trade data for identical issues in which related trading activity is not sufficiently frequent to be considered a Level 1 input or that of comparable securities. At the time of purchase, all short-term and long-term investments had an “A” or better rating by Standard & Poor’s.

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The following summarizes the Company’s investments at ~~June~~September 30, 2020 and December 31, 2019 (in thousands):

June 30, 2020 Investments Cost Gross
Unrealized
Gains Gross
Unrealized
Losses Fair Value
(Level 2)
Short-term:
   Asset-backed securities $ 61,567 $ 471 $ — $ 62,038
   Commercial paper 15,472 22 — 15,494
   Corporate bonds 169,767 941 — 170,708
      Subtotal 246,806 1,434 — 248,240
Long-term:
   Corporate bonds 8,205 56 — 8,261
      Subtotal 8,205 56 — 8,261
         Total $ 255,011 $ 1,490 $ — $ 256,501

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September 30, 2020 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)
Short-term:
Asset-backed securities	$	57,729	$	259	$	0	$	57,988
Commercial paper	137,298		41		0		137,339
Corporate bonds	158,368		550		(6)		158,912
U.S. Treasury notes	52,642		2		(2)		52,642
Subtotal	406,037		852		(8)		406,881
Long-term:


U.S. Treasury notes	44,059		6		(3)		44,062
Subtotal	44,059		6		(3)		44,062
Total	$	450,096	$	858	$	(11)	$	450,943


December 31, 2019 Investments	December 31, 2019 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)		December 31, 2019 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)
Short-term:	Short-term:									Short-term:
Asset-backed securities	Asset-backed securities	$	43,166	$	54	$	—	$	43,220	Asset-backed securities	$	43,166	$	54	$	0	$	43,220
Commercial paper	Commercial paper	32,250		20		—		32,270		Commercial paper	32,250		20		0		32,270
Corporate bonds	Corporate bonds	138,012		225		(5)		138,232		Corporate bonds	138,012		225		(5)		138,232
Subtotal	Subtotal	213,428		299		(5)		213,722		Subtotal	213,428		299		(5)		213,722
Long-term:	Long-term:									Long-term:
Asset-backed securities	Asset-backed securities	28,064		10		(15)		28,059		Asset-backed securities	28,064		10		(15)		28,059
Corporate bonds	Corporate bonds	36,706		37		(4)		36,739		Corporate bonds	36,706		37		(4)		36,739
Subtotal	Subtotal	64,770		47		(19)		64,798		Subtotal	64,770		47		(19)		64,798
Total	Total	$	278,198	$	346	$	(24)	$	278,520	Total	$	278,198	$	346	$	(24)	$	278,520

At ~~June~~September 30, 2020, there were no investments held for sale that were materially less than their amortized cost.

The Company elects to recognize its interest receivable separate from its ~~available for sale~~available-for-sale investments. At ~~June~~September 30, 2020 and December 31, 2019, the interest receivable recognized in prepaid expenses and other current assets was ~~$1.7~~$1.6 million and $1.4 million, respectively.

Equity Investment

At ~~both June~~September 30, 2020 and December 31, 2019, the Company held an equity investment in TELA Bio, Inc., or TELA Bio, in its condensed consolidated balance sheets in the amount of $12.8 million and $10.0 ~~million.~~million, respectively. The Company records its investment in TELA Bio at fair value based on a quoted market price based on Level 1 inputs, which resulted in an unrealized gain in the amount of ~~$4.0~~$2.8 million during both the three and nine months ended ~~June~~September 30, 2020, ~~and an unrealized gain of less than $0.1 million~~which are recorded in other, net income (expense) in the ~~six months ended June 30, 2020. The fair values at both June 30, 2020 and December 31, 2019 were based on Level 1 inputs.~~condensed consolidated statements of operations.

Credit Risk

Financial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash and cash equivalents, short-term investments, long-term investments and accounts receivable. The Company maintains its cash and cash equivalents with high-credit quality financial institutions. Such amounts may exceed federally-insured limits.

As of ~~June~~September 30, 2020, ~~three~~3 wholesalers each accounted for over 10% of the Company’s accounts receivable, at 33%, ~~30%~~28% and ~~26%~~27%. At December 31, 2019, ~~three~~3 wholesalers each accounted for over 10% of the Company’s accounts receivable, at 37%, 29% and 26%. For additional information regarding the Company’s wholesalers, see Note 2, Summary of Significant Accounting Policies. EXPAREL revenues are primarily derived from major wholesalers and pharmaceutical companies that generally have significant cash resources. The Company performs ongoing credit evaluations of its customers as

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warranted and generally does not require collateral. Allowances for credit losses on the Company’s accounts receivable are maintained based on historical payment patterns, current and estimated future economic conditions, aging of accounts receivable and its write-off history. As of ~~June~~September 30, 2020 and December 31, 2019, the Company did 0t deem any allowances for credit losses on its accounts receivable necessary.

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NOTE 11—STOCK PLANS

Stock-Based Compensation

The Company recognized stock-based compensation expense in the periods presented as follows (in thousands):


		Three Months Ended June 30,						Six Months Ended June 30,							Three Months Ended September 30,				Nine Months Ended September 30,
		2020		2019		2020		2019			2020		2019		2020		2019
Cost of goods sold	Cost of goods sold	$	1,284	$	1,156	$	2,503	$	2,247	Cost of goods sold	$	1,546	$	1,243	$	4,050	$	3,490
Research and development	Research and development	1,357		1,257		2,544		2,475		Research and development	1,401		1,297		3,944		3,772
Selling, general and administrative	Selling, general and administrative	6,581		5,370		13,023		10,495		Selling, general and administrative	8,007		6,704		21,030		17,199
Total	Total	$	9,222	$	7,783	$	18,070	$	15,217	Total	$	10,954	$	9,244	$	29,024	$	24,461

Stock-based compensation from:	Stock-based compensation from:									Stock-based compensation from:
Stock options	Stock options	$	6,388	$	5,378	$	12,614	$	10,499	Stock options	$	7,181	$	6,418	$	19,795	$	16,917
Restricted stock units	Restricted stock units	2,636		2,204		5,037		4,311		Restricted stock units	3,552		2,639		8,589		6,950
Employee stock purchase plan	Employee stock purchase plan	198		201		419		407		Employee stock purchase plan	221		187		640		594
Total	Total	$	9,222	$	7,783	$	18,070	$	15,217	Total	$	10,954	$	9,244	$	29,024	$	24,461

Equity Awards

The following tables contain information about the Company’s stock option and restricted stock unit, or RSU, activity for the ~~six~~nine months ended ~~June~~September 30, 2020:


Stock Options	Stock Options	Number of Options	Weighted Average Exercise Price (Per Share)		Stock Options	Number of Options	Weighted Average Exercise Price (Per Share)
Outstanding at December 31, 2019	Outstanding at December 31, 2019	6,706,378	$	42.80	Outstanding at December 31, 2019	6,706,378	$	42.80
Granted	Granted	1,346,703	46.72		Granted	1,470,003	47.27
Exercised	Exercised	(427,606)	27.26		Exercised	(1,129,762)	32.08
Forfeited	Forfeited	(150,954)	41.93		Forfeited	(403,467)	41.90
Expired	Expired	(31,982)	61.24		Expired	(44,177)	61.63
Outstanding at June 30, 2020		7,442,539	44.34
Outstanding at September 30, 2020					Outstanding at September 30, 2020	6,598,975	45.56


Restricted Stock Units	Restricted Stock Units	Number of Units	Weighted Average Grant Date Fair Value (Per Share)		Restricted Stock Units	Number of Units	Weighted Average Grant Date Fair Value (Per Share)
Unvested at December 31, 2019	Unvested at December 31, 2019	631,141	$	41.87	Unvested at December 31, 2019	631,141	$	41.87
Granted	Granted	564,326	47.35		Granted	631,526	48.18
Vested	Vested	(235,835)	41.91		Vested	(238,060)	41.91
Forfeited	Forfeited	(32,059)	42.72		Forfeited	(88,308)	43.93
Unvested at June 30, 2020		927,573	45.16
Unvested at September 30, 2020					Unvested at September 30, 2020	936,299	45.92

The weighted average fair value of stock options granted during the ~~six~~nine months ended ~~June~~September 30, 2020 ~~was $22.05~~ was $22.30 per share. The fair values of stock options granted were estimated using the Black-Scholes option valuation model with the following weighted average assumptions:

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Black-Scholes Weighted Average Assumption						~~Six~~Nine Months Ended ~~June~~September 30, 2020
Expected dividend yield						NaN
Risk-free interest rate						~~0.57%~~0.55%
Expected volatility						53.48%
Expected term of options						5.36 years

Employee Stock Purchase Plan

The Company’s 2014 Employee Stock Purchase Plan, or ESPP, features 2 six-month offering periods per year, running from January 1to June 30 and July 1 to December 31. Under the ESPP, employees may elect to contribute after-tax earnings to purchase shares at 85% of the closing fair market value of the Company’s common stock on either the offering date or the purchase date, whichever is less. During the ~~six~~nine months ended ~~June~~September 30, 2020, 36,668 shares were purchased and issued through the ESPP.

NOTE 12—STOCKHOLDERS’ EQUITY

Accumulated Other Comprehensive Income (Loss)

The following table illustrates the changes in the balances of the Company’s accumulated other comprehensive income (loss) for the periods presented (in thousands):


		Six Months Ended June 30,							Nine Months Ended September 30,
Net unrealized gains (losses) from available for sale investments:		2020		2019
Net unrealized gains (losses) from available-for-sale investments:						Net unrealized gains (losses) from available-for-sale investments:	2020		2019
Balance at beginning of period	Balance at beginning of period	$	322	$	(280)	Balance at beginning of period	$	322	$	(280)
Other comprehensive income before reclassifications	Other comprehensive income before reclassifications	1,168		780		Other comprehensive income before reclassifications	525		727
Amounts reclassified from accumulated other comprehensive income (loss)	Amounts reclassified from accumulated other comprehensive income (loss)	—		—		Amounts reclassified from accumulated other comprehensive income (loss)	0		0
Balance at end of period	Balance at end of period	$	1,490	$	500	Balance at end of period	$	847	$	447

NOTE 13—NET INCOME (LOSS) PER SHARE

Basic net income (loss) per share is calculated by dividing the net income (loss) attributable to common shares by the weighted average number of common shares outstanding during the period. Diluted net income (loss) per common share is calculated by dividing the net income (loss) attributable to common shares by the weighted average number of common shares outstanding plus dilutive potential common shares outstanding during the period.

Potential common shares include the shares of common stock issuable upon the exercise of outstanding stock options, the vesting of RSUs, the purchase of shares from the ESPP (using the treasury stock method) and the conversion of the excess conversion value on the 2022 Notes and 2025 Notes. As discussed in Note 9, Debt, the Company has the option to pay cash for the aggregate principal amount due upon the conversion of its 2022 Notes and 2025 Notes. Since it is the Company’s intent to settle the principal amount of its 2022 Notes and 2025 Notes in cash, the potentially dilutive effect of such notes on net income (loss) per share is computed under the treasury stock method.

Potential common shares are ~~excluded~~excluded from the diluted net income (loss) per share computation to the extent they would be antidilutive. Because the Company reported a net loss for the three and nine months ended ~~June 30, 2020 and the six months ended June~~September 30, 2019, no potentially dilutive securities have been included in the computation of diluted net loss per share for those periods.

The following table sets forth the computation of basic and diluted net ~~loss~~income (loss) per share for the three and ~~six months~~nine months ended ~~June~~September 30, 2020 and 2019 (in thousands, except per share amounts):

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		Three Months Ended June 30,									Six Months Ended June 30,									Three Months Ended September 30,						Nine Months Ended September 30,
				2020			2019			2020			2019			2020			2019			2020			2019
Numerator:	Numerator:												Numerator:
Net income (loss)	Net income (loss)	$	(7,269)		$	2,730		$	889		$	(41)	Net income (loss)	$	130,119		$	(6,087)		$	131,008		$	(6,128)

Denominator:	Denominator:												Denominator:
Weighted average common shares outstanding—basic	Weighted average common shares outstanding—basic	42,221			41,384			42,126			41,312		Weighted average common shares outstanding—basic	42,928			41,645			42,393			41,423
Computation of diluted securities:	Computation of diluted securities:												Computation of diluted securities:
Dilutive effect of stock options	Dilutive effect of stock options	—			810			567			—		Dilutive effect of stock options	1,086			0			740			0
Dilutive effect of RSUs	Dilutive effect of RSUs	—			148			168			—		Dilutive effect of RSUs	261			0			200			0

Dilutive effect of ESPP purchase options		—			3			—			—

Weighted average common shares outstanding—diluted	Weighted average common shares outstanding—diluted	42,221			42,345			42,861			41,312		Weighted average common shares outstanding—diluted	44,275			41,645			43,333			41,423
Net income (loss) per share:	Net income (loss) per share:												Net income (loss) per share:
Basic net income (loss) per common share	Basic net income (loss) per common share	$	(0.17)		$	0.07		$	0.02		$	(0.00)	Basic net income (loss) per common share	$	3.03		$	(0.15)		$	3.09		$	(0.15)
Diluted net income (loss) per common share	Diluted net income (loss) per common share	$	(0.17)		$	0.06		$	0.02		$	(0.00)	Diluted net income (loss) per common share	$	2.94		$	(0.15)		$	3.02		$	(0.15)

The following outstanding stock options, RSUs and ESPP purchase options are antidilutive in the periods presented (in thousands):


		Three Months Ended June 30,			Six Months Ended June 30,				Three Months Ended September 30,		Nine Months Ended September 30,
		2020	2019	2020	2019		2020	2019	2020	2019
Weighted average number of stock options	Weighted average number of stock options	6,804	4,426	5,327	5,932	Weighted average number of stock options	3,585	5,443	4,746	4,816
Weighted average number of RSUs	Weighted average number of RSUs	681	190	186	570	Weighted average number of RSUs	5	266	126	154

Weighted average ESPP purchase options	Weighted average ESPP purchase options	37	—	20	36	Weighted average ESPP purchase options	25	33	22	23

Total	Total	7,522	4,616	5,533	6,538	Total	3,615	5,742	4,894	4,993

NOTE 14—INCOME TAXES

Income (loss) before income taxes and total income tax (benefit) expense is as follows (in thousands):


		Three Months Ended June 30,						Six Months Ended June 30,							Three Months Ended September 30,				Nine Months Ended September 30,
		2020		2019		2020		2019			2020		2019		2020		2019
Income (loss) before income taxes:	Income (loss) before income taxes:									Income (loss) before income taxes:
Domestic	Domestic	$	(6,645)	$	3,760	$	6,400	$	5,580	Domestic	$	8,175	$	(3,205)	$	10,154	$	(2,183)
Foreign	Foreign	(666)		(2,633)		(5,155)		(6,970)		Foreign	(2,025)		(2,611)		(2,759)		(5,024)
Total income (loss) before income taxes	Total income (loss) before income taxes	$	(7,311)	$	1,127	$	1,245	$	(1,390)	Total income (loss) before income taxes	$	6,150	$	(5,816)	$	7,395	$	(7,207)

Current taxes:										Current taxes:
Federal										Federal	$	0	$	0	$	0	$	0
State										State	603		271		959		749

Total current taxes										Total current taxes	$	603	$	271	$	959	$	749
Deferred taxes:										Deferred taxes:
Federal										Federal	$	(104,389)	$	0	$	(104,389)	$	(1,828)
State										State	(20,183)		0		(20,183)		0

Total deferred taxes										Total deferred taxes	$	(124,572)	$	0	$	(124,572)	$	(1,828)

Total income tax (benefit) expense										Total income tax (benefit) expense	$	(123,969)	$	271	$	(123,613)	$	(1,079)

For the three months ended ~~June~~September 30, 2020 and 2019, the Company recorded an income tax benefit of ~~less than $0.1~~$124.0 million and ~~$1.6~~income tax expense of $0.3 million, respectively. For the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019, the Company recorded ~~income tax expense of $0.4 million and~~ an income tax benefit of ~~$1.3~~$123.6 million and $1.1 million, respectively. ~~The~~During the three months ended September 30,

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2020, the Company recorded a $124.6 million income tax ~~provisions recorded for 2020 and 2019 reflect current state income taxes.~~benefit relating to the release of a valuation allowance on its net deferred assets. The income tax benefit for the ~~three and six~~nine months ended ~~June~~September 30, 2019 is primarily related to the MyoScience Acquisition and a $1.8 million reduction in the Company’s valuation allowance on its deferred tax assets due to the acquisition. ~~Due~~

Deferred taxes reflect the tax effects of the differences between the amounts recorded as assets and liabilities for financial reporting purposes and the comparable amounts recorded for income tax purposes. A full valuation allowance had been recorded against the Company’s net deferred tax balance as of December 31, 2019 because at that time it was more likely than not that its net deferred tax assets would not be realizable. At each reporting date, the Company considers new evidence, both positive and negative, that could affect its view of the future realization of deferred tax assets. As of September 30, 2020, in part because in the current year the Company achieved three years of cumulative pretax income in the U.S. federal and state tax jurisdictions, and based on its most recent forecasts, the Company determined that there is sufficient positive evidence to conclude that it is more likely than not that additional deferred taxes of $124.6 million are realizable and, therefore, reduced the valuation allowance accordingly.

During the nine months ended September 30, 2020, the Company established a deferred tax liability of $20.5 million with an offset to additional paid-in capital resulting from the conversion feature of the 2025 Notes. The initial difference between the book value of convertible debt issued with a beneficial conversion feature and its tax basis is a temporary difference.

The significant components of the Company’s deferred tax assets and liabilities at September 30, 2020 and December 31, 2019 are as follows (in thousands):


	September 30,		December 31,
	2020		2019
Deferred tax assets:
Net operating loss carryforwards	$	66,262	$	68,921
Federal and state credits	17,197		16,895
Depreciation and amortization	16,203		15,778
Accruals and reserves	8,043		8,767

Stock based compensation	22,315		23,187
Inventory	1,671		1,646
Other	1,257		2,022
Total deferred tax assets	132,948		137,216
Deferred tax liabilities:
Discount on convertible senior notes	(22,215)		(8,125)
Deferred tax assets, net of deferred tax liabilities	110,733		129,091
Less: valuation allowance	(6,611)		(129,091)
Net deferred tax assets	$	104,122	$	0

As of September 30, 2020, the Company’s deferred tax assets were primarily the result of U.S. net operating losses, or ~~NOLs, carried forward, and the repeal~~NOLs. As of ~~the corporate minimum tax, no current federal income tax expense was recorded for~~September 30, 2020, or 2019. The utilization of the Company’s NOLs has not resulted in any deferred federal tax expense because there was a full valuation allowance recorded with respect to the NOLs. However, if the Company’s results of operations continue to improve, the Company ~~may be required~~had federal, state, and foreign NOL carry forwards of approximately $255.7 million, $182.3 million, and $5.8 million, respectively. All federal carry forward losses were generated prior to ~~reverse some or all of the valuation allowance on its deferred tax assets~~2018 and will expire in ~~the second half of 2020.~~2025 through 2037. The state carry forwards will expire at various dates beginning in 2025. The foreign NOLs have an indefinite expiration.

Utilization of NOLs may be subject to a substantial limitation pursuant to Section 382 of the Internal Revenue Code, or IRC, of 1986, as amended, or Section 382, as well as similar state statutes in the event of an ownership change. Such ownership changes have occurred in the past and could occur again in the future. Under Section 382 of the IRC, if a corporation undergoes an “ownership change” generally defined as a greater than 50% change (by value) in its equity ownership over a three-year period, the corporation’s ability to use its pre-change NOLs and other pre-change tax attributes (such as research and development tax credits) to offset its post-change income may be limited. The Company may experience ownership changes in the future as a result of shifts in its stock ownership, some of which are outside the Company’s control. Ownership changes in future periods may place additional limits on the Company’s ability to utilize its net operating loss and tax credit carry forwards. In addition, at the state level, there may be periods during which the use of NOLs is suspended or otherwise limited, which could accelerate or permanently increase state taxes owed.

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NOTE 15—ACQUISITION–RELATED CHARGES (GAINS) ~~CHARGES~~ AND PRODUCT DISCONTINUATION, NET

MyoScience Acquisition

The Company recognized ~~acquisition-related~~ charges ~~related to the MyoScience Acquisition in the amount~~ of ~~$1.6~~$0.8 million and ~~acquisition-related~~ gains of ~~$2.2~~$1.4 million in the three and ~~six~~nine months ended ~~June~~September 30, 2020, ~~respectively. The majority of these charges and gains represented~~respectively, primarily related to changes in the fair value of contingent ~~consideration. In these~~consideration from the MyoScience Acquisition. There were $7.3 million in charges for the fair value of contingent consideration in the three and ~~six month periods, there were~~nine months ended September 30, 2019. In addition, the Company also recognized charges of ~~less than $0.1~~$0.2 million and ~~$0.1 million, respectively, for legal, accounting and other related costs. The Company recognized acquisition-related charges of $3.4 million and $4.6~~$4.8 million in the three and ~~six~~nine months ended ~~June~~September 30, 2019, respectively, related to separation costs, asset write-downs and other restructuring charges. ~~There were 0 changes in the value of contingent consideration in the three and six months ended June 30, 2019.~~ See Note 10, Financial Instruments, for information regarding the methods and key assumptions used in the fair value measurements of contingent consideration.

DepoCyt(e) Discontinuation

The Company recorded gains related to its DepoCyt(e) discontinuation activities of ~~$0.2~~less than $0.1 million and ~~$0.1~~$0.2 million in the three and ~~six~~nine month periods ended ~~June~~September 30, 2020, respectively. The Company recorded costs for its DepoCyt(e) discontinuation activities of $0.1 million in both the three and ~~six~~nine month periods ended ~~June~~September 30, 2019. The Company ceased all production of DepoCyt(e) as of June 30, 2017. Cash payments for the DepoCyt(e) manufacturing facility ~~are expected to be~~were substantially finalized in the third quarter of 2020.

Summary of Acquisition-Related Restructuring Activities and DepoCyt(e) Discontinuation Costs

The Company’s acquisition-related restructuring and DepoCyt(e) discontinuation costs as of ~~June~~September 30, 2020 are summarized below (in thousands):


		Severance and Related Costs		Asset Retirement Obligations, Other Restructuring and Discontinuation Costs		Total			Severance and Related Costs		Asset Retirement Obligations, Other Restructuring and Discontinuation Costs		Total
Balance at December 31, 2019	Balance at December 31, 2019	$	81	$	558	$	639	Balance at December 31, 2019	$	81	$	558	$	639
Charges incurred	Charges incurred	—		21		21		Charges incurred	0		(39)		(39)
Cash payments made	Cash payments made	(81)		(449)		(530)		Cash payments made	(81)		(500)		(581)
Balance at June 30, 2020		$	—	$	130	$	130
Balance at September 30, 2020								Balance at September 30, 2020	$	0	$	19	$	19

NOTE 16—COMMITMENTS AND CONTINGENCIES

From time to time, the Company has been and may again become involved in legal proceedings arising in the ordinary course of its business, including those related to patents, product liability and government investigations. ~~The~~Except as described below, the Company is not presently a party to any legal proceedings that it believes to be material, and is not aware of any pending or threatened litigation against the Company which it believes could have a material adverse effect on its business, operating results, financial condition or cash flows.

MyoScience Milestone Litigation

In August 2020, the Company and its subsidiary, Pacira CryoTech, Inc. (“Pacira CryoTech”), filed a lawsuit in the Court of Chancery of the State of Delaware against Fortis Advisors LLC (“Fortis”), solely in its capacity as representative for the former securityholders of MyoScience, and certain other defendants, seeking declaratory judgment with respect to certain terms of the merger agreement for the MyoScience Acquisition (the “Merger Agreement”), specifically related to the achievement of certain milestone payments under the Merger Agreement. In addition, the Company and Pacira CryoTech sought general, special and compensatory damages against the other defendants related to breach of fiduciary duties in connection with the purported achievement of milestone payments under the Merger Agreement, and breach of the Merger Agreement and certain other agreements with the defendants. In October 2020, Fortis filed an answer and counterclaim against the Company and Pacira CryoTech seeking to recover certain milestone payments under the Merger Agreement totaling $40.0 million, and attorneys’ fees. The Company believes that the counterclaim from Fortis is without merit and intends to vigorously defend against all claims. The Company is unable to predict the outcome of this action at this time.

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Department of Justice Inquiry Settlement

In April 2015, the Company received a subpoena from the U.S. Department of Justice, U.S. Attorney’s Office for the District of New Jersey pertaining to marketing and promotional practices related to EXPAREL. In July 2020, the Company formally entered into settlement agreements that resolved all outstanding investigations and claims by the United States Department of Justice, the United States Department of Health and Human Services, various States Attorneys’ General and a private plaintiff. This agreement concludes a five-year investigation related to the sale and marketing of EXPAREL. Under the various settlement agreements, the Company paid a global settlement of $3.5 million, which was previously recorded in acquisition-related charges, product discontinuation and other in the consolidated financial statements for the year ended December 31, 2019. The Company expressly denies all allegations and contentions and has admitted no wrongdoing in connection with the settlement agreements. The Company has been given assurances that this concludes the investigation that originated from the U.S. Department of Justice subpoena in April 2015.

NOTE 17—COMMERCIAL PARTNERS

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~~NOTE 17—SUBSEQUENT EVENTS~~

~~Convertible Senior Notes Due 2025~~

On July 10, 2020, the Company completed a private placement of $402.5 million in aggregate principal amount of its 2025 Notes and entered into the 2025 Indenture with respect to the 2025 Notes. The 2025 Notes accrue interest at a fixed rate of 0.75% per year, payable semiannually in arrears on February 1^st ~~and August 1~~^st of each year, beginning on February 1, 2021. The 2025 Notes mature on August 1, 2025. The net proceeds from the issuance of the 2025 Notes were approximately $389.9 million, after deducting commissions and the estimated offering expenses payable by the Company. A portion of the net proceeds from the 2025 Notes were used by the Company to repurchase $185.0 million of its then-outstanding 2022 Notes in privately-negotiated transactions for a total of $211.1 million of cash (including accrued interest). For more information, see Note 9, ~~Debt~~.

~~Holders may convert the 2025 Notes at any time prior to the close of business on the business day immediately preceding February 3, 2025, only under the following circumstances:~~

(i) during any calendar quarter commencing after the calendar quarter ending on September 30, 2020 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;

~~(ii) during the~~ ~~five~~ ~~business day period immediately after any~~ ~~five~~ consecutive trading day period (the ‘‘measurement period’’) in which the trading price (as defined in the 2025 Indenture) per $1,000 principal amount of notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day;

~~(iii) upon the occurrence of specified corporate events, including a merger or a sale of all or substantially all of the Company’s assets; or~~

~~(iv) if the Company calls the 2025 Notes for redemption, until the close of business on the business day immediately preceding the redemption date.~~

~~On or after February 3, 2025, until the close of business on the second scheduled trading day immediately preceding August 1, 2025, holders may convert their 2025 Notes at any time.~~

Upon conversion, holders will receive the principal amount of their 2025 Notes and any excess conversion value, calculated based on the per share volume-weighted average price for each of the 40 consecutive trading days during the observation period (as more fully described in the 2025 Indenture). For both the principal and excess conversion value, holders may receive cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s option. The initial conversion rate for the 2025 Notes is 13.9324 shares of common stock per $1,000 principal amount, which is equivalent to an initial conversion price of $71.78 per share of the Company’s common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. The initial conversion price of the 2025 Notes represents a premium of approximately 32.5% to the closing sale price of $54.17 per share of the Company’s common stock on the Nasdaq Global Select Market on July 7, 2020, the date that the Company priced the private offering of the 2025 Notes.

~~Prior to August 1, 2023, the Company may not redeem the 2025 Notes. On or after August 1, 2023 (but, in the case of a redemption of less than all of the outstanding 2025 Notes, no later than the 40~~^th scheduled trading day immediately before the maturity date), the Company may redeem for cash all or part of the 2025 Notes if the last reported sale price (as defined in the 2025 Indenture) of the Company’s common stock has been at least 130% of the conversion price then in effect for (i) each of at least 20 trading days (whether or not consecutive) during any 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related notice of redemption and (ii) the trading day immediately before the date the Company sends such notice. The redemption price will equal the sum of (i) 100% of the principal amount of the 2025 Notes being redeemed, plus (ii) accrued and unpaid interest, including additional interest, if any, to, but excluding, the redemption date. In addition, calling the 2025 Notes for redemption will constitute a “make-whole fundamental change ” (as defined in the 2025 Indenture) and will, in certain circumstances, increase the conversion rate applicable to the conversion of such notes if it is converted in connection with the redemption. No sinking fund is provided for the 2025 Notes.

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If the Company undergoes a fundamental change, as defined in the 2025 Indenture, subject to certain conditions, holders of the 2025 Notes may require the Company to repurchase for cash all or part of their 2025 Notes at a repurchase price equal to 100% of the principal amount of the 2025 Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. In addition, if a ‘‘make-whole fundamental change’’ (as defined in the 2025 Indenture) occurs prior to August 1, 2025, the Company will, in certain circumstances, increase the conversion rate for a holder who elects to convert its notes in connection with the make-whole fundamental change.

~~Termination of Agreement with~~ DePuy Synthes Sales, Inc.

In July 2020, the Company announced the termination of the Co-Promotion Agreement, dated January 24, 2017 between the Company and DePuy Synthes Sales Inc. to jointly market and promote the use of EXPAREL for orthopedic procedures in the United States. The Company currently estimates termination-related costs or payments to be up to $12.0 million, which will be recorded in selling, general and administrative ~~expenses.~~

expenses over the remaining contract service period.

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Item 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Management’s Discussion and Analysis of Financial Condition and Results of Operations is based upon our condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States of America (GAAP) and in accordance with the rules and regulations of the United States Securities and Exchange Commission, or SEC.

This Quarterly Report on Form 10-Q and certain other communications made by us contain forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, including statements about our growth and future operating results ~~discovery~~ and trends, development of products, strategic alliances and intellectual property. For this purpose, any statement that is not a statement of historical fact should be considered a forward-looking statement. We often use the words “believe,” “anticipate,” “plan,” “estimate,” “expect,” “intend,” “may,” “will,” “would,” “could,” “can” and similar expressions to help identify forward-looking statements. We cannot assure you that our estimates, assumptions and expectations will prove to have been correct. These forward-looking statements include, among others, statements about: the impact of the COVID-19 pandemic on elective surgeries, our manufacturing and supply chain, ~~and~~ global and U.S. economic ~~conditions; the impact of the COVID-19 pandemic on~~conditions, and our business, including our revenues, financial condition and results of operations; the cost and timing of an early termination payment to DePuy Synthes Sales, Inc., or DePuy Synthes; the success of our sales and manufacturing efforts in support of the commercialization of EXPAREL^®(bupivacaine liposome injectable suspension); the rate and degree of market acceptance of EXPAREL; the size and growth of the potential markets for EXPAREL and our ability to serve those markets; our plans to expand the use of EXPAREL to additional indications and opportunities, and the timing and success of any related clinical trials for EXPAREL; our ability to realize the anticipated benefits and synergies from the acquisition of MyoScience, Inc., or MyoScience; the success of our sales and manufacturing efforts in support of the commercialization of iovera°^®; the rate and degree of market acceptance of iovera°; the size and growth of the potential markets for iovera° and our ability to serve those markets; our plans to expand the use of iovera° to additional indications and opportunities, and the timing and success of any related clinical trials for iovera°; the related timing and success of United States Food and Drug Administration, or FDA, supplemental New Drug Applications, or sNDAs; ~~the Company’s~~our plans to evaluate, develop and pursue additional DepoFoam^®-based product candidates; the approval of the commercialization of our products in other jurisdictions; clinical trials in support of an existing or potential DepoFoam-based product; our commercialization and marketing capabilities and our ability to successfully construct an additional EXPAREL manufacturing suite in Swindon, ~~England~~England; the outcome of any litigation; the recoverability of our deferred tax assets and assumptions associated with contingent consideration payments. Important factors could cause our actual results to differ materially from those indicated or implied by forward-looking statements. We undertake no intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, and readers should not rely on the forward-looking statements as representing our views as of any date subsequent to the date of the filing of this Quarterly Report on Form 10-Q.

These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by these statements. These factors include items mentioned herein and the matters discussed and referenced in Part I-Item 1A. “Risk Factors” included in our Annual Report on Form 10-K for the year ended December 31, 2019 and in other reports as filed with the SEC, including this Quarterly Report on Form 10-Q.

Unless the context requires otherwise, references to “Pacira,” “we,” the “Company,” “us” and “our” in this Quarterly Report on Form 10-Q refer to Pacira BioSciences, Inc. and its subsidiaries. In addition, references in this Quarterly Report on Form 10-Q to DepoCyt(e) mean DepoCyt^® when discussed in the context of the United States, or U.S., and Canada and DepoCyte^® when discussed in the context of the European Union, or E.U.

Overview

Pacira is athe leading provider of non-opioid pain management options to advance and improve outcomes for healthcare practitioners and their patients. Our long-acting, local analgesic EXPAREL^® (bupivacaine liposome injectable suspension) was commercially launched in April 2012. EXPAREL utilizes DepoFoam^®, a unique and proprietary delivery technology that encapsulates drugs without altering their molecular structure and releases them over a desired period of time. EXPAREL is currently indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. Since its initial approval in 2011 for single-dose infiltration, more than seven million patients have been treated with EXPAREL. We drop-ship EXPAREL directly to the end-user based on orders placed to wholesalers or directly to us, and there is no product held by wholesalers. In April 2019, we acquired iovera°^®,

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a handheld cryoanalgesia device used to deliver a precise, controlled application of cold temperature only to targeted nerves.

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We sell iovera° directly to end users. The iovera° system is highly complementary to EXPAREL as a non-opioid therapy that alleviates pain by disrupting pain signals being transmitted to the brain from the site of injury or surgery.

We expect to continue to pursue the expanded use of EXPAREL and iovera° in additional procedures; progress our earlier-stage product candidate pipeline; advance regulatory activities for EXPAREL, iovera° and other product candidates; invest in sales and marketing resources for EXPAREL and iovera°; expand and enhance our manufacturing capacity for EXPAREL and iovera°; invest in products, businesses and technologies and support legal matters.

Novel Coronavirus (COVID-19) Pandemic

During the second quarter of 2020, our net product sales were negatively impacted by the global pandemic caused by a novel strain of coronavirus (COVID-19), which mandated significant postponement or suspension in the scheduling of elective surgical procedures resulting from public health guidance and government directives. Elective surgery restrictions began to lift on a state-by-state basis in April 2020; however, we do not know how long ~~other states will mandate stay at home orders or how long~~ it will take the surgical community to return to normal ~~operations.~~operations, or if restrictions on elective surgeries will recur. Our manufacturing sites are operational and have implemented new safety protocols and guidelines as recommended by federal, state and local governments. Our Fremont, California facility, where we manufacture iovera°, was closed for three weeks in March 2020 to implement safety protocols and guidelines, and resumed normal operations in April 2020. To date, there have been no material impacts to our supply chain. With the reopening of many states, the ability of our sales representatives to renew their in-person engagement efforts, in conjunction with remote efforts, has occurred across all sites of care, with more focus on physician offices and ambulatory surgical centers. Our offices have re-opened on a voluntary basis with strict safety and hygiene guidelines ~~implemented; however~~implemented, and we continue to ~~encourage~~support remote working ~~wherever possible.~~as appropriate.

The situation remains dynamic and is subject to rapid and possibly material changes. It is not clear what the potential effects may be to our business going forward, including the impact on our revenues, results of operations or financial condition, particularly if these pandemic conditions persist or exacerbate over an extended period of time, including if ~~and when~~ states ~~will~~ return to placing restrictions on elective surgical procedures. Additional negative impacts may also arise from the COVID-19 pandemic that we are unable to foresee. The nature and extent of such impacts will depend on future developments, which are highly uncertain and cannot be predicted. We have also taken advantage of some of the provisions of the Coronavirus Aid, Relief and Economic Security (CARES) Act, mainly by deferring the payment of certain employer payroll taxes. For more information, see “Liquidity and Capital Resources” below.

We will continue to actively monitor the situation and implement measures recommended by federal, state or local authorities, or that we determine are in the best interests of our patients, employees, partners, suppliers, shareholders and stakeholders. For a description of risks facing the Company that relate to the COVID-19 pandemic or any other future pandemic, epidemic or outbreak of contagious disease, see Item 1A. “Risk Factors” below.

Recent Highlights

• In August 2020, we announced that the FDA has accepted the submission of our sNDA seeking expansion of the EXPAREL label to include single-dose infiltration to provide postsurgical analgesia in children aged six and over. The expected action date by the FDA under the Prescription Drug User Fee Act, or PDUFA, is March 22, 2021.

• In July 2020, we completed a private placement of $402.5 million in aggregate principal amount of ~~0.75%~~0.750% convertible senior notes due 2025, or 2025 Notes. We used part of the net proceeds from the issuance of the 2025 Notes to repurchase $185.0 million in aggregate principal amount of our 2.375% convertible senior notes due 2022, or 2022 Notes, in privately-negotiated transactions for an aggregate of approximately $211.1 million in cash (including accrued interest). For more information, see Note ~~17,~~9, ~~Subsequent Events~~Debt, to our condensed consolidated financial statements included herein and “Liquidity and Capital Resources” below.

• In ~~July~~September 2020, we announced that the European Medicines Agency’s, or EMA, Committee for Medicinal Products for Human Use, or CHMP, adopted a positive opinion recommending marketing authorization for EXPAREL for postsurgical analgesia. The European Commission will review the CHMP opinion and is expected to adopt a final decision in November 2020. The decision will be applicable to all 27 E.U. member states plus the United Kingdom, Iceland, Norway and Liechtenstein.

•In October 2020, we announced the ~~termination~~grand opening of the ~~Co-Promotion Agreement, dated January 24, 2017 between us~~Pacira Innovation and ~~DePuy Synthes~~Training center at Tampa (the “PITT”). Designed to ~~jointly market~~advance clinician understanding of the latest local, regional and ~~promote~~field block approaches for managing pain, the ~~use of EXPAREL~~PITT will provide training for ~~orthopedic procedures in the United States. We currently estimate termination-related costs~~anesthesiologists and surgeons working to reduce or ~~payments~~eliminate patient exposure to ~~be up to $12.0 million, which will be recorded in selling, general and administrative expenses. For more information, see Note 17,~~ ~~Subsequent Events, to our condensed consolidated financial statements included herein.~~

opioids.

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EXPAREL

EXPAREL is currently indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. Safety and efficacy have not been established in other nerve blocks.

~~Due to the COVID-19 pandemic, our clinical trial activities, including those described below, have experienced delays due to the postponement or suspension of elective surgical procedures.~~

Phase 4 Trials

We are expanding the clinical evidence for EXPAREL through Phase 4 clinical trials across several surgical specialties.

We have completed two successful studies of EXPAREL in patients undergoing Cesarean section, or C-section. The first study compared an EXPAREL transversus abdominis plane, or TAP, block to a bupivacaine TAP block.

This was a multicenter, randomized, double-blind study across 13 clinical sites in the United States, in patients undergoing elective C-section and receiving spinal anesthesia and a multimodal analgesic regimen. Patients were randomized (1:1) to receive EXPAREL 266 mg plus bupivacaine HCl 50 mg or bupivacaine HCl 50 mg alone administered via TAP field block after delivery. ~~Effectiveness~~Efficacy was evaluated in a pre-specified modified intent-to-treat (mITT) population which met the study criteria regarding proper administration of TAP and multimodal regimen (N=136). Key findings include:

•Significant reduction in total opioid consumption with EXPAREL plus bupivacaine HCl versus bupivacaine HCl

•52% reduction through 72 hours, the primary endpoint of the study (least squares mean [LSM] standard error [SE], 15.5 [6.67] vs 32.0 [6.25] mg, respectively; p=0.012)

•49% reduction at one week (LSM [SE], 23.3 [9.75] vs 45.8 [9.13] mg, respectively; p=0.018)

•41% reduction of opioid consumption at two weeks, although results did not reach statistical significance (LSM [SE], 28.2 [11.20] vs 47.8 [10.49] mg, respectively; p=0.054)

•Significantly higher percentage of opioid-spared patients with EXPAREL versus bupivacaine HCl, defined as patients who took no more than one oxycodone 10 mg tablet (or equivalent) with no opioid-related side effects through 72 hours

•The percentage of opioid-spared patients was 2.2 times higher in the EXPAREL group vs bupivacaine HCl group (54% vs 25%, respectively; p=0.001)

These data were published in the peer reviewed journal, Anesthesia and Analgesia, in August 2020.

In January 2020, we reported positive topline results from a second C-section study (known as “CHOICE”). The study achieved its primary endpoint with a statistically significant reduction in total postsurgical opioid consumption while maintaining pain scores through 72 hours (p≤0.001). EXPAREL demonstrated statistical significance for the key secondary endpoint of a reduction in the incidence and severity of itching for 72 hours after surgery (p≤0.05). The Phase 4, multicenter, randomized, active-controlled study across 18 clinical sites in the United States, enrolled 167 patients undergoing elective C-section. Patients were randomized (1:1:1) to receive either 150 mcg morphine spinal anesthesia plus a standard of care postoperative pain regimen, 50 mcg morphine spinal anesthesia plus EXPAREL TAP field block or morphine-free spinal anesthesia plus EXPAREL TAP block. Patients in the EXPAREL arms received a protocol-defined postoperative pain management regimen comprised of ketorolac, acetaminophen and ibuprofen. All patients could receive opioid rescue pain medicine upon request for breakthrough pain. The study achieved its primary endpoint with a statistically significant reduction in total postsurgical opioid consumption while maintaining pain scores through 72 hours (p≤0.001). EXPAREL demonstrated statistical significance for the key secondary endpoint of a reduction in the incidence and severity of itching for 72 hours after surgery (p≤0.05). Full study results will be submitted for publication in the peer-reviewed medical literature later this year.

We recently discontinued enrollment in our Phase 4 study in spine surgeries (known as “FUSION”). This multicenter, prospective, active-controlled, real world study compared EXPAREL in multimodal regimens to the standard of care for postsurgical pain management in patients undergoing lumbar posterior spine surgeries. While the use of EXPAREL continues to significantly expand in spinal procedures, medical practice is rapidly evolving with regional approaches becoming more widespread and procedures shifting to the 23-hour stay environment. Given this changing treatment landscape, we closed enrollment early as the protocol was becoming less feasible and less reflective of current practice. The data from approximately 65 FUSION study subjects will be analyzed with the intent to create either a future study or registry for this patient population.

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In surgical settings where we are seeing positive outcomes for EXPAREL as part of an enhanced recovery after surgery, or ERAS, protocol (such as colorectal, breast reconstruction and hip fracture procedures), we are investing in training around the protocol and collecting real-world data on the standard-of-care without EXPAREL compared to an EXPAREL-based ERAS protocol. Our Phase 4 strategy also supports clinician education on procedure-specific best-practice care for improved patient outcomes and customer satisfaction within our approved indications.

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~~Phase 3~~ Label Expansion ~~Trials~~

Pediatrics

In December 2019, we reported positive topline results from our Phase 3 registration study (known as “PLAY”) of EXPAREL administered as a single-dose infiltration in pediatric patients undergoing spinal or cardiac surgeries. Overall findings were consistent with the pharmacokinetic and safety profiles for adult patients with no safety concerns identified at a dose of 4 mg/kg. Based on the positive data from the PLAY study, we submitted an sNDA to the FDA seeking expansion of the EXPAREL label to include single-dose infiltration to provide postsurgical analgesia in children aged six and over. The sNDA has ~~been filed with the FDA with~~ a ~~PDUFA~~Prescription Drug User Fee Act (PDUFA) action date of March 22, 2021.

The PLAY study enrolled 98 patients to evaluate the pharmacokinetics and safety of EXPAREL for two patient groups: patients aged 12 to less than 17 years and patients aged 6 to less than 12 years. In agreement with the FDA, the primary and secondary objectives of the PLAY study were to evaluate the pharmacokinetics and safety of EXPAREL, respectively. The full study results will be submitted for publication in the peer-reviewed medical literature.

We are also working with the FDA to finalize a regulatory pathway to expand the EXPAREL label to include EXPAREL administered as a nerve block in the pediatric setting.

Nerve Block in Lower Extremity Surgery

We are initiating a Phase 3 study for nerve block in lower extremity surgeries (known as “STRIDE”) that is comparing EXPAREL nerve blocks in lower extremity surgeries to bupivacaine nerve blocks in lower extremity surgeries in patients undergoing foot and ankle surgeries. We have been working closely with the FDA on the design of this study to maximize the chances of supporting an sNDA submission seeking label expansion to include nerve blocks in lower extremity surgeries should the study hit its primary endpoints. We believe the addition of this indication is significant as anesthesia-driven regional approaches using nerve and field blocks continue to expand as institutional protocols.

Global Expansion

We have defined a global expansion strategy for EXPAREL that we believe provides us with the opportunity to increase our revenue and leverage our fixed cost infrastructure. ~~We have prioritized Europe, Canada and China.~~ In ~~Europe, we have secured~~September 2020, the EMA’s CHMP adopted a positive opinion recommending marketing authorization for ~~our Pediatric Investigation Plan (PIP)~~EXPAREL for postsurgical analgesia.The CHMP is a scientific committee of the EMA that reviews medical product applications on their scientific and clinical merit. The CHMP recommended granting EXPAREL marketing authorization with the following indication: EXPAREL is indicated as a brachial plexus block or femoral nerve block for treatment of post-operative pain in ~~June 2019 our Marketing Authorization Application, or MAA, was validated by~~adults, and as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds in adults. The European Commission will review the ~~European Medicines Agency, or EMA.~~CHMP opinion and is expected to adopt a final decision in November 2020. The ~~MAA is currently in late-stage review as we work towards~~decision will be applicable to all 27 E.U. ~~approval.~~member states plus the United Kingdom, Iceland, Norway and Liechtenstein. In Canada, which is a concentrated market driven by four provinces, Health Canada has validated our New Drug ~~Submission.~~Submission and we are currently in labeling discussions. We do not intend to pursue a commercial partnership to commercialize EXPAREL in Europe or Canada. In China, we have an agreement with Nuance Biotech Co. Ltd., a China-based specialty pharmaceutical company, for the development and commercialization of EXPAREL. We have completed a pharmacokinetic study requested by the National Medical Products Administration, or NMPA, in China, and we are planning to meet with the NMPA to finalize our regulatory path forward. There is no assurance that we will receive approval from the European Commission, Health Canada, the NMPA or any other jurisdiction.

iovera°

The iovera° System

The iovera° system is highly complementary to EXPAREL as a non-opioid therapy that ~~delivers~~produces cryoanalgesia via a handheld device ~~to alleviate pain~~ by disrupting pain signals ~~being~~ transmitted to the brain from the site of injury or ~~surgery. Initially, we will focus on two broad patient care opportunities.~~surgery and alleviates pain. The iovera° system is 510(k) cleared in the U.S., has a CE mark in the E.U. and is cleared for marketing in Canada for the blocking of pain, pain relief and symptoms associated with osteoarthritis of the knee as well as general surgical use.

Our commercial strategy for iovera° focuses on two broad market segments. First, iovera° and EXPAREL for opioid-sparing pain management for the total knee arthroplasty, or TKA, patient, with iovera° being administered before surgery and

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EXPAREL administered during surgery. ~~Later this year, we expect to begin enrollment in~~We are enrolling patients into our PREPARE study that will evaluate iovera° and EXPAREL for TKA. As many as 30 percent of presurgical patients with end-stage knee osteoarthritis use prescription opioids.

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With iovera°, our goal is to provide patients with several months of non-opioid pain control to allow them to prepare for surgery with an appropriate regimen. We also believe that EXPAREL for surgical pain control and EXPAREL plus iovera° for postsurgical pain control could support rapid functional recovery.

The second target market is iovera° for osteoarthritis patients who have failed conservative treatments, such as non-steroidal anti-inflammatory drugs or viscosupplementation, and are seeking drug-free, opioid-free, surgery-free pain management for several months. We are targeting patients who are seeking an active lifestyle, as well as patients who desire to delay surgery for personal or medical reasons.

Osteoarthritis of the Knee

There is a growing body of clinical data demonstrating success with the iovera° treatment for osteoarthritis of the knee. There are 14 million individuals in the U.S. who have symptomatic knee osteoarthritis, and nearly two million are under the age of 45. Surgical intervention is typically a last resort for patients suffering from osteoarthritis of the knee. In one study, the majority of the patients suffering from osteoarthritis of the knee experienced pain relief beyond 150 days after being treated with iovera°.

Preliminary findings demonstrated reductions in opioids, including:

•The daily morphine equivalent was significantly lower at 72 hours (p<0.05), 6 weeks (p<0.05) and 12 weeks (p<0.05), with an overall 35 percent reduction in daily morphine equivalents across the 12-week postoperative period in the iovera° treatment group.

•Patients who were administered iovera° were far less likely to take opioids six weeks after surgery. The number of patients taking opioids six weeks after TKA in the control group was three times the number of patients taking opioids in the cryoanalgesia group (14% vs. 44%, p<0.01).

•Patients in the iovera° group demonstrated a statistically significant reduction in pain scores from their baseline pain scores at 72 hours (p<0.05) and at 12 weeks (p<0.05).

We believe these data validate iovera° as a clinically meaningful non-opioid alternative for patients undergoing TKA, and that iovera° offers the opportunity to provide patients with non-opioid pain control well in advance of any necessary surgical intervention through a number of key product attributes:

•iovera° is safe and effective with immediate pain relief that can last for ~~several~~ months as the nerve regenerates over time;

•iovera° is repeatable;

•The iovera° technology does not risk damage to the surrounding tissue;

•iovera° is a convenient handheld device with a single-use procedure-specific smart tip; and

•iovera° can be delivered precisely using ultrasound guidance or an anatomical landmark.

We believe the combination of iovera° and EXPAREL will become the preferred procedural solution that will empower patients and their healthcare providers to take control of the patients’ osteoarthritis journey, while minimizing the need for opioids. We will be investing in key clinical studies to demonstrate the synergy of iovera° and EXPAREL to manage pain while reducing or eliminating opioids.

Product Pipeline

Given the proven safety, flexibility and customizability of our DepoFoam platform for acute, sub-acute and chronic pain applications, we have additional DepoFoam-based products in preclinical development. Following data readouts from ~~animal~~preclinical and ~~other~~ feasibility studies for these candidates, we have prioritized two programs for clinical development: (i) the intrathecal delivery of a DepoFoam-based analgesic for acute and chronic pain and (ii) DepoDexmedetomidine, a sedative-analgesic for end-of-life pain and painful conditions in the elderly.

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We plan to invest in clinical initiatives to broaden the scope of iovera° applications and improve its functionality for current and future end users. This will be accomplished through enhancements across the product line, which is comprised of single-use disposable units as well as non-disposable handheld devices.

In parallel, our business development team continues to pursue innovative acquisition targets that align with our strategy and are complementary to EXPAREL and iovera° by thoughtfully pursuing adjacent opportunities that are of great interest to the surgical and anesthesia audiences we are already calling on today. Our goal is to build a portfolio of customer-focused non-opioid and regenerative health solutions to improve patients’ journeys along the neural pain pathway.

Results of Operations

Comparison of the Three and ~~Six~~Nine Months Ended ~~June~~September 30, 2020 and 2019

Revenues

Net product sales consist of sales of EXPAREL in the U.S., our bupivacaine liposome injectable suspension to Aratana Therapeutics, Inc., or Aratana, for veterinary use in the U.S. and sales of iovera° in the U.S. Licensing, milestone and royalty revenues are from our collaborative licensing agreements.

The following table provides information regarding our revenues during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,					% Increase / (Decrease)			Six Months Ended June 30,								% Increase / (Decrease)		Three Months Ended September 30,						% Increase / (Decrease)				Nine Months Ended September 30,				% Increase / (Decrease)
																								Three Months Ended September 30,									Nine Months Ended September 30,		% Increase / (Decrease)
		2020		2019					2020			2019				% Increase / (Decrease)	2020			2019		% Increase / (Decrease)								2019		% Increase / (Decrease)
Net product sales:	Net product sales:													Net product sales:
EXPAREL	EXPAREL	$	73,046	$	98,868	(26)%	$	174,315		$	189,482		(8)%	EXPAREL	$		$		101,456		12%				$	290,938			(1)%
Bupivacaine liposome injectable suspension	Bupivacaine liposome injectable suspension	775		921		(16)%	1,981			1,213			63%	Bupivacaine liposome injectable suspension	449		255			76%				2,430				1,468			66%
Total EXPAREL / bupivacaine liposome injectable suspension net product sales	Total EXPAREL / bupivacaine liposome injectable suspension net product sales	73,821		99,789		(26)%	176,296			190,695			(8)%	Total EXPAREL / bupivacaine liposome injectable suspension net product sales	114,163		101,711			12%				290,459				292,406			(1)%
iovera°	iovera°	1,395		2,035		(31)%	3,665			2,035			80%	iovera°	2,726		2,639			3%		6,391				4,674				37%
Total net product sales	Total net product sales	75,216		101,824		(26)%	179,961			192,730			(7)%	Total net product sales	116,889		104,350			12%		296,850				297,080				(0)%

Royalty revenue	Royalty revenue	289		780		(63)%	1,228			1,187			3%	Royalty revenue	595		335			78%		1,823				1,522				20%
Total revenues	Total revenues	$	75,505	$	102,604	(26)%	$	181,189		$	193,917		(7)%	Total revenues	$	117,484	$	104,685		12%		$	298,673			$	298,602			0%

EXPAREL revenue grew 12% in the three months ended September 30, 2020 versus 2019, primarily due to an increase in sales volume of 13% and a 3% increase in gross selling price per unit, partially offset by the sales mix of EXPAREL vial sizes. The ~~26% and 8% decreases~~1% decrease in net product sales of EXPAREL in the ~~three and six~~nine months ended ~~June~~September 30, 2020 versus 2019 ~~respectively,~~ was primarily due to the significant postponement or suspension ~~in the scheduling~~ of elective surgical procedures resulting from public health guidance and government directives due to the COVID-19 pandemic, beginning in mid-March 2020. For the three and six months ended June 30, 2020, there were decreases of 29% and 12%, respectively, in gross unit volume combined with changes in the sales mix of EXPAREL vial sizes. These decreases were partially offset by an increase in gross selling price per unit. The demand for EXPAREL has generally continued to increase as a result of ambulatory surgical centers and anesthesiologists broadening the use of long-acting EXPAREL regional approaches as a foundation of multimodal opioid-minimization strategies that enable shifting inpatient procedures to 23-hour sites of care.

As part of the acquisition of MyoScience (the “MyoScience Acquisition”), we acquired the iovera° system and began recognizing net product sales in April 2019. Net product sales ~~decreased 31%~~increased 3% and 37% in the three ~~months~~ and ~~increased 80% in the six~~nine months ended ~~June~~September 30, 2020 versus 2019, ~~respectively, due to the impact of the COVID-19 pandemic and~~respectively. The increase in nine month revenue largely reflects the timing of the ~~acquisition~~MyoScience Acquisition in 2019. The increase in three month revenue was impacted by the COVID-19 pandemic. Thus far, we have seen the greatest iovera° demand as pain relief for patients in advance of TKA procedures and in chronic pain management, particularly for people with mild to severe osteoarthritis of the knee.

Any ~~continued~~renewed government suspension of or ~~renewed governmental suspension of~~patient or clinical decisions to delay elective surgeries would impact our future sales of EXPAREL and iovera°~~, as would patient or clinical decisions~~ during the ongoing COVID-19 pandemic.

Royalty revenue reflects the royalties earned on sales to Aratana. Royalty revenue ~~decreased 63%~~increased 78% and 20% in the three ~~months~~ and ~~increased 3% in the six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively, as a result of the timing of orders placed by Aratana.

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The following tables provide a summary of activity with respect to our sales related allowances and accruals related to EXPAREL for the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019 (in thousands):


June 30, 2020		Returns Allowances		Prompt Payment Discounts		Wholesaler Service Fees		Volume Rebates and Chargebacks		Total
September 30, 2020												September 30, 2020	Returns Allowances		Prompt Payment Discounts		Wholesaler Service Fees		Volume Rebates and Chargebacks		Total
Balance at December 31, 2019	Balance at December 31, 2019	$	540	$	962	$	1,486	$	1,816	$	4,804	Balance at December 31, 2019	$	540	$	962	$	1,486	$	1,816	$	4,804
Provision	Provision	334		3,609		2,759		4,640		11,342		Provision	561		5,947		4,519		7,409		18,436
Payments / Adjustments	Payments / Adjustments	(142)		(3,704)		(3,398)		(4,868)		(12,112)		Payments / Adjustments	(230)		(5,997)		(5,029)		(7,736)		(18,992)
Balance at June 30, 2020		$	732	$	867	$	847	$	1,588	$	4,034
Balance at September 30, 2020												Balance at September 30, 2020	$	871	$	912	$	976	$	1,489	$	4,248


June 30, 2019		Returns Allowances		Prompt Payment Discounts		Wholesaler Service Fees		Volume Rebates and Chargebacks		Total
September 30, 2019												September 30, 2019	Returns Allowances		Prompt Payment Discounts		Wholesaler Service Fees		Volume Rebates and Chargebacks		Total
Balance at December 31, 2018	Balance at December 31, 2018	$	344	$	779	$	1,167	$	1,010	$	3,300	Balance at December 31, 2018	$	344	$	779	$	1,167	$	1,010	$	3,300
Provision	Provision	363		3,905		2,989		4,645		11,902		Provision	558		6,009		4,602		7,593		18,762
Payments / Adjustments	Payments / Adjustments	(191)		(3,877)		(3,177)		(4,274)		(11,519)		Payments / Adjustments	(400)		(5,922)		(4,768)		(7,167)		(18,257)
Balance at June 30, 2019		$	516	$	807	$	979	$	1,381	$	3,683
Balance at September 30, 2019												Balance at September 30, 2019	$	502	$	866	$	1,001	$	1,436	$	3,805

Total reductions to gross product sales from sales-related allowances and accruals were ~~$11.3~~$18.4 million and ~~$11.9~~$18.8 million, or ~~5.9%~~5.8% and ~~5.8%~~5.9% of gross product sales, for the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019, respectively. The overall ~~increase~~decrease in sales-related allowances and accruals as a percentage of gross product sales was directly related to ~~an increase~~a slight decrease in ~~discounting driven by higher sales volume from customers with discount contracts.~~discounting.

Cost of Goods Sold

Cost of goods sold primarily relates to the costs to produce, package and deliver our products to customers. These expenses include labor, raw materials, manufacturing overhead and occupancy costs, depreciation of facilities, royalty payments, quality control and engineering.

The following table provides information regarding our cost of goods sold and gross margin during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)				Six Months Ended June 30,									% Increase / (Decrease)			Three Months Ended September 30,					% Increase / (Decrease)			Nine Months Ended September 30,				% Increase / (Decrease)
																												Three Months Ended September 30,								Nine Months Ended September 30,		% Increase / (Decrease)
		2020			2019							2020				2019				% Increase / (Decrease)	2020				2019		% Increase / (Decrease)						2019		% Increase / (Decrease)
Cost of goods sold	Cost of goods sold	$	22,305		$	25,201		(11)%	$	52,037			$	52,505			(1)%	Cost of goods sold	$		$			22,304		34%					$	74,809		10%
Gross margin	Gross margin	70		%	75		%		71		%		73		%			Gross margin	74		79		%					75	%

Gross margin decreased five percentage points in the three months ended ~~June~~September 30, 2020 versus 2019. Of the decrease, the most significant changes were two percentage points ~~related~~due to ~~inventory write-offs, two~~higher cost of product sold, one percent percentage ~~points were the result of~~point due to unplanned downtime at our custom manufacturing suite in Swindon, England (under our partnership with Thermo Fisher Scientific Pharma Services, or Thermo Fisher), and one percentage point ~~was~~ due to ~~lower gross margin on iovera°.~~a planned shutdown at the company’s Science Center Campus in San Diego, California in order to prepare our manufacturing suite for a new EXPAREL capacity expansion.

Gross margin decreased two percentage points in the ~~six~~nine months ended ~~June~~September 30, 2020 versus ~~2019. There was a two percentage point decrease due to inventory write-offs and a two percentage point decrease~~2019 as a result of unplanned downtime at our custom manufacturing suite in Swindon, England (under our partnership with Thermo Fisher)~~, which were partially offset by a two percentage point increase due to lower cost of product sold for EXPAREL produced at the Swindon site.~~.

Despite shelter-in-place and other restrictive orders to combat the COVID-19 pandemic in California and England, there were no interruptions to our EXPAREL operations at either the Science Center Campus or Swindon manufacturing sites as a result of the COVID-19 pandemic as the production of EXPAREL is considered essential. Our Fremont, California facility, where we manufacture iovera°, was closed for three weeks in March 2020 to implement safety protocols and guidelines related to the COVID-19 pandemic. The Fremont facility resumed normal operations in April 2020.

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Research and Development Expenses

Research and development expenses primarily consist of costs related to clinical trials and related outside services, product development and other research and development costs, including Phase 4 trials that we are conducting to generate new data for EXPAREL and stock-based compensation expense. Clinical and preclinical development expenses include costs for clinical personnel, clinical trials performed by third-parties, toxicology studies, materials and supplies, database management and other third-party fees. Product development and manufacturing capacity expansion expenses include development costs for our products, which include personnel, equipment, materials and contractor costs for process development and product candidates, development costs related to significant scale-ups of our manufacturing capacity and facility costs for our research space. Regulatory and other expenses include regulatory activities related to unapproved products and indications, medical information expenses and related personnel. Stock-based compensation expense relates to the costs of stock option grants, awards of restricted stock units, or RSUs, and our employee stock purchase plan, or ESPP.

The following table provides a breakout of our research and development expenses during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)				Six Months Ended June 30,										% Increase / (Decrease)			Three Months Ended September 30,						% Increase / (Decrease)					Nine Months Ended September 30,				% Increase / (Decrease)
																															Three Months Ended September 30,									Nine Months Ended September 30,		% Increase / (Decrease)
		2020			2019							2020				2019				% Increase / (Decrease)		2020				2019		% Increase / (Decrease)									2019		% Increase / (Decrease)
Clinical and preclinical development	Clinical and preclinical development	$	4,363		$	7,669		(43)%	$	10,648			$	13,193			(19)%	Clinical and preclinical development	$			$			9,762		(45)%								$	22,956		(30)%
Product development and manufacturing capacity expansion	Product development and manufacturing capacity expansion	6,084			6,812			(11)%	12,688				13,213				(4)%	Product development and manufacturing capacity expansion	5,629			7,782				(28)%					20,996				(13)%
Regulatory and other	Regulatory and other	1,816			2,089			(13)%	3,560				3,329				7%	Regulatory and other	2,252			1,414				59%					5,813				4,742			23%
Stock-based compensation	Stock-based compensation	1,357			1,257			8%	2,544				2,475				3%	Stock-based compensation	1,401			1,297				8%		3,944				3,772					5%
Total research and development expense	Total research and development expense	$	13,620		$	17,827		(24)%	$	29,440			$	32,210			(9)%	Total research and development expense	$	14,651		$	20,255			(28)%		$	44,090			$	52,466				(16)%
% of total revenues	% of total revenues	18		%	17		%		16		%		17		%			% of total revenues	12		%	19		%				15		%		18		%

Total research and development expense decreased ~~24%~~28% and 9%16% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively.

~~The 43% and 19% decreases in clinical~~Clinical and preclinical development expense decreased 45% in the three ~~and six~~ months ended ~~June~~September 30, 2020 versus 2019 ~~respectively, is~~ due to the completion of our Phase 3 pediatric (“PLAY”) clinical trial, our ~~two~~ Phase 4 C-Section ~~trials~~(“CHOICE”) trial and our ~~pediatric~~nerve block pilot pharmacokinetic study. In addition, ~~due to the COVID-19 pandemic, enrollment in our spine (“FUSION”) trial was suspended. Subsequently,~~ we made the strategic decision to conclude enrollment in the ~~FUSION~~spine (“FUSION”) study early due to protocol feasibility given the rapid evolution of medical practice for spinal procedures. The data from approximately 65 FUSION study subjects will be analyzed with the intent to create either a future study or registry for this patient population. These decreases were partially offset by ~~our pectoral field block clinical trial in breast augmentation, as well as~~ startup activities related to ~~both~~our iovera° and EXPAREL (“PREPARE”) trial, our lower extremity nerve block (“STRIDE”) clinical trial and a Phase 1 intrathecal clinical trial to evaluate the safety and pharmacokinetics of EXPAREL administered via a single intrathecal injection. The decrease of 30% in the nine months ended September 30, 2020 versus 2019 also included the completion of our pediatric pharmacokinetic study, partially offset by our pectoral field block clinical trial in breast augmentation.

Product development and manufacturing capacity expansion expense decreased ~~11%~~28% and 4%13% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively. These decreases are mainly due to our progress in constructing the significant scale-up of our manufacturing capacity at the Thermo Fisher site in Swindon, England as the project advances from the development phase to the registration phase.

Regulatory and other expense ~~decreased 13%~~increased 59% and 23% in the three and nine months ended ~~June~~September 30, 2020 versus 2019, respectively, due to start-up activities related to ~~our European Marketing Authorization Application, or MAA, for EXPAREL in 2019.~~an iovera° clinical data registry. For the ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, these expenditures ~~increased 7% due to increased~~included increases in publications of EXPAREL and iovera° abstracts.

Stock-based compensation increased by 8% and 3%5% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively, primarily due to accelerated stock compensation expense that occurred in the third quarter of 2020 and an increase in the number of equity awards granted.

Selling, General and Administrative Expenses

Sales and marketing expenses primarily consist of compensation and benefits for our sales force and personnel that support our sales, marketing, medical and scientific affairs operations, commission payments to our marketing partners for the

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promotion and sale of EXPAREL and iovera°, expenses related to communicating the health outcome benefits of EXPAREL and educational programs for our customers. General and administrative expenses consist of compensation and benefits for

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legal, finance, regulatory activities related to approved products and indications, compliance, information technology, human resources, business development, executive management and other supporting personnel. It also includes professional fees for legal, audit, tax and consulting services. Stock-based compensation expense relates to the costs of stock option grants, RSU awards and our ESPP.

The following table provides information regarding our selling, general and administrative expenses during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)				Six Months Ended June 30,										% Increase / (Decrease)			Three Months Ended September 30,						% Increase / (Decrease)					Nine Months Ended September 30,				% Increase / (Decrease)
																															Three Months Ended September 30,									Nine Months Ended September 30,		% Increase / (Decrease)
		2020			2019							2020				2019				% Increase / (Decrease)		2020				2019		% Increase / (Decrease)									2019		% Increase / (Decrease)
Sales and marketing	Sales and marketing	$	25,356		$	32,312		(22)%	$	53,268			$	63,869			(17)%	Sales and marketing	$			$			31,913		4%								$	95,782		(10)%
General and administrative	General and administrative	11,405			11,444			0%	21,831				22,067				(1)%	General and administrative	11,339			11,511				(1)%					33,578				(1)%
Stock-based compensation	Stock-based compensation	6,581			5,370			23%	13,023				10,495				24%	Stock-based compensation	8,007			6,704				19%					21,030				17,199			22%
Total selling, general and administrative expense	Total selling, general and administrative expense	$	43,342		$	49,126		(12)%	$	88,122			$	96,431			(9)%	Total selling, general and administrative expense	$	52,561		$	50,128			5%		$	140,683			$	146,559				(4)%
% of total revenues	% of total revenues	57		%	48		%		49		%		50		%			% of total revenues	45		%	48		%				47		%		49		%

Total selling, general and administrative expenses increased 5% and decreased ~~12% and 9%~~4% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively.

Sales and marketing expenses increased 4% and decreased ~~22% and 17%~~10% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively. The 4% increase was driven by a termination fee related to our co-promotion agreement with DePuy Synthes and higher compensation due to an expanded sales force, and was partially offset by lower sales commissions, outside services and travel and entertainment. The 10% decrease was primarily driven by a decline in sales commissions, ~~related to our co-promotion agreement with DePuy Synthes as a result of the suspension of elective surgeries due to the COVID-19 pandemic. Marketing~~reduced marketing spend ~~decreased~~ due to the cancellations of in person meetings, medical conferences, travel and higher utilization of lower cost virtual meetings due to the COVID-19 pandemic. These were partially offset by the termination fee to DePuy Synthes, and higher ~~Sales~~sales and ~~Marketing~~marketing compensation due to ~~increased headcount.~~an expanded sales force. We are continuing our marketing investment in ~~EXPAREL—including~~EXPAREL, which includes educational initiatives and programs related to the impact of opioids and postsurgical pain management and our national advocacy campaign designed to educate patients about non-opioid treatment options. We ~~are also nearing completion~~recently launched the Pacira Innovation and Training center at Tampa (the “PITT”) in Tampa, Florida. This approximately 10,000 square-foot facility will support a full range of educational events to advance clinician understanding of the ~~build-out of a 20,000 square foot innovation~~latest local, regional and ~~training center in Tampa, Florida, which will allow~~field block approaches for ~~interactive customer training—hands-on and/~~managing pain and reducing or ~~virtually—related~~eliminating exposure to ~~both infiltration technique and best practice regional approaches to improve patient care.~~opioids. Additionally, we have continued investing in marketing initiatives and customer outreach for iovera°.

In the near-term, we expect that sales and marketing expenditures will continue to be impacted by the COVID-19 pandemic and its resultant effects on elective surgeries, sales commissions, cancellations of in-person industry conferences and the suspension of non-essential employee travel. These potential reductions in expenditures could be partially offset by athe termination ~~fee related to~~of our Co-Promotion Agreement with DePuy ~~Synthes. For more information, see Note 17,~~ ~~Subsequent Events~~,Synthes to ~~our condensed consolidated financial statements included herein.~~jointly market and promote the use of EXPAREL for orthopedic procedures in the United States. We currently estimate termination-related costs or payments to be up to $12.0 million, which will be recorded in selling, general and administrative expenses over the remaining contract service period.

General and administrative expenses ~~were flat~~decreased slightly for both the three and nine months ended ~~June 30, 2020 versus 2019 and decreased 1% in the six months ended June~~September 30, 2020 versus 2019. The ~~decrease was~~decreases were primarily due to lower legal expenditures related to our U.S. Department of Justice subpoena received in April 2015, which was partially offset by expenditures to support the expansion of the business following the MyoScience Acquisition.

Stock-based compensation increased ~~23%~~19% and ~~24%~~22% in the three and ~~six~~nine months ended ~~June~~September 30, 2020 versus 2019, respectively, primarily due to an increase in personnel and the number of equity grants awarded.

Amortization of Acquired Intangible Assets

The following table provides a summary of the amortization of acquired intangible assets during the periods indicated, including percent changes (dollar amounts in thousands):

Three Months Ended
June 30, % Increase / (Decrease) Six Months Ended
June 30, % Increase / (Decrease)
2020 2019 2020 2019
Amortization of acquired intangible assets $ 1,967 $ 1,770 11% $ 3,933 $ 1,770 100% +

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	Three Months Ended September 30,				% Increase / (Decrease)	Nine Months Ended September 30,				% Increase / (Decrease)

	2020		2019			2020		2019
Amortization of acquired intangible assets	$	1,967	$	1,967	—%	$	5,900	$	3,736	58%

As part of the MyoScience Acquisition, we acquired intangible assets consisting of developed technology and customer relationships, with estimated useful lives of 14 and 10 years, respectively. Amortization began in the second quarter of 2019 on

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a straight-line basis. For more information, see Note 8, Goodwill and Intangible Assets, to our condensed consolidated financial statements included herein.

Acquisition-Related Charges (Gains) and Product Discontinuation, Net

The following table provides a summary of the costs related to the MyoScience Acquisition and our DepoCyt(e) discontinuation activities during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,					% Increase / (Decrease)			Six Months Ended June 30,								% Increase / (Decrease)		Three Months Ended September 30,					% Increase / (Decrease)			Nine Months Ended September 30,				% Increase / (Decrease)
																							Three Months Ended September 30,								Nine Months Ended September 30,		% Increase / (Decrease)
		2020		2019					2020			2019				% Increase / (Decrease)	2020			2019		% Increase / (Decrease)						2019		% Increase / (Decrease)
Acquisition-related charges (gains)	Acquisition-related charges (gains)	$	1,577	$	3,357	(53)%	$	(2,162)		$	4,570		N/A	Acquisition-related charges (gains)	$		$		7,571		(90)%					$	12,142		N/A
Product discontinuation charges (gains)	Product discontinuation charges (gains)	(159)		48		N/A	(128)			77			N/A	Product discontinuation charges (gains)	(60)		47			N/A			124			N/A

Total acquisition-related charges (gains) and product discontinuation, net	Total acquisition-related charges (gains) and product discontinuation, net	$	1,418	$	3,405	(58)%	$	(2,290)		$	4,647		N/A	Total acquisition-related charges (gains) and product discontinuation, net	$	692	$	7,618		(91)%			$	(1,599)		$	12,266		N/A

As part of the MyoScience Acquisition, we recognized ~~acquisition-related~~ charges in the amount of ~~$1.6~~$0.8 million and ~~acquisition-related~~ gains of ~~$2.2~~$1.4 million in the three and ~~six~~nine months ended ~~June~~September 30, 2020, ~~respectively. The majority of these charges and gains represented~~respectively, primarily related to changes in the fair value of contingent consideration. ~~In these~~There were $7.3 million in fair value adjustments related to contingent consideration in the three and ~~six month periods, there were~~nine months ended September 30, 2019. We also recognized charges of ~~less than $0.1~~$0.2 million and ~~$0.1 million, respectively, for legal, accounting and other related costs. We recognized acquisition-related charges of $3.4 million and $4.6~~$4.8 million in the three and ~~six~~nine months ended ~~June~~September 30, 2019, respectively, related to separation costs, asset write-downs and other restructuring charges. ~~There were no changes in the value of contingent consideration in the three and six months ended June 30, 2019.~~ See Note 10, Financial Instruments, to our condensed consolidated financial statements included herein, for information regarding the methods and key assumptions used in the fair value measurements of contingent consideration.

In the three and ~~six~~nine months ended ~~June~~September 30, 2020, we recorded gains of ~~$0.2~~$0.1 million and ~~$0.1~~$0.2 million, respectively, related to asset retirement obligations and exiting the former DepoCyt(e) production facility. We recorded charges of less than $0.1 million and $0.1 million in ~~both of~~ the three and ~~six~~nine month periods ended ~~June~~September 30, 2019, respectively, for contract and exit costs related to the discontinuation of DepoCyt(e).

Other Income (Expense)

The following table provides information regarding other (expense) income during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,					% Increase / (Decrease)			Six Months Ended June 30,								% Increase / (Decrease)		Three Months Ended September 30,					% Increase / (Decrease)				Nine Months Ended September 30,				% Increase / (Decrease)
																								Three Months Ended September 30,								Nine Months Ended September 30,		% Increase / (Decrease)
		2020		2019					2020			2019				% Increase / (Decrease)	2020			2019		% Increase / (Decrease)							2019		% Increase / (Decrease)
Interest income	Interest income	$	1,323	$	1,817	(27)%	$	2,911		$	3,973		(27)%	Interest income	$		$		1,736		(41)%						$	5,709		(31)%
Interest expense	Interest expense	(5,456)		(5,878)		(7)%	(11,477)			(11,691)			(2)%	Interest expense	(7,132)		(5,940)			20%				(17,631)			6%

Loss on early extinguishment of debt														Loss on early extinguishment of debt	(8,071)		—			N/A				(8,071)			—			N/A
Other, net	Other, net	3,969		(87)		N/A	(136)			(26)			100% +	Other, net	2,708		(4,025)			N/A		2,571			(4,051)				N/A
Total other expense, net	Total other expense, net	$	(164)	$	(4,148)	(96)%	$	(8,702)		$	(7,744)		12%	Total other expense, net	$	(11,470)	$	(8,229)		39%		$	(20,173)		$	(15,973)			26%

Total other expense, net ~~decreased~~increased by ~~96%~~39% and 26% in the three and nine months ended ~~June~~September 30, 2020 versus 2019, respectively, primarily due to an $8.1 million loss on early extinguishment of debt incurred in conjunction with the retirement of $185.0 million aggregate principal of our 2022 Notes in July 2020. In addition, the three and nine months ended September 30, 2020 included a ~~$4.0~~$2.8 million unrealized gain on our equity investment in TELA Bio, Inc., or TELA Bio. The three and nine months ended September 30, 2019 included a $5.4 million unrealized loss in the TELA Bio investment due to

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the ~~fluctuations~~investment having been deemed to be impaired when an offer was made to sell shares in ~~market value as of June 30, 2020.~~ TELA Bio for an amount less than our carrying amount. TELA Bio has since completed an initial public offering.

There was ~~also~~ a reduction in interest income in both the three and nine months ended September 30, 2020 versus 2019, respectively, due to a decline in interest ~~rates that was partially offset by a reduction~~rates. The increase in interest expense in both respective periods was due to ~~increased capitalized interest related to a new EXPAREL capacity expansion project at our Science Center Campus.~~

~~Total other expense, net increased by 12%~~the issuance of $402.5 million of aggregate principal 2025 Notes in ~~the six months ended June 30, 2020 versus 2019, primarily due to a $1.1 million reduction in interest income due to a decline in interest rates.~~July 2020.

Income Tax (Benefit) Expense

The following table provides information regarding our income tax (benefit) expense during the periods indicated, including percent changes (dollar amounts in thousands):

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		Three Months Ended June 30,							% Increase / (Decrease)				Six Months Ended June 30,									% Increase / (Decrease)			Three Months Ended September 30,					% Increase / (Decrease)			Nine Months Ended September 30,				% Increase / (Decrease)
																												Three Months Ended September 30,								Nine Months Ended September 30,		% Increase / (Decrease)
		2020			2019							2020				2019				% Increase / (Decrease)	2020				2019		% Increase / (Decrease)						2019		% Increase / (Decrease)
Income tax (benefit) expense	Income tax (benefit) expense	$	(42)		$	(1,603)		(97)	$	356			$	(1,349)			N/A	Income tax (benefit) expense	$		$			271		N/A					$	(1,079)		100% +
Effective tax rate	Effective tax rate	(1)		%	(142)		%		29		%		97		%			Effective tax rate	(100)% +		(5)		%					15	%

For the three months ended ~~June~~September 30, 2020 and 2019, we recorded an income tax benefit of ~~less than $0.1~~$124.0 million and ~~$1.6~~income tax expense of $0.3 million, respectively. For the ~~six~~nine months ended ~~June~~September 30, 2020 and 2019, we recorded ~~income tax expense of $0.4 million and~~ an income tax benefit of ~~$1.3~~$123.6 million and $1.1 million, respectively. The tax provisions recorded for 2020 and 2019 reflect current state income taxes. The income tax benefit for the three and six months ended June 30, 2019 is primarily related to the MyoScience Acquisition and a $1.8 million reduction in ourA full valuation allowance onhad been recorded against our net deferred tax balance as of December 31, 2019 because at that time it was more likely than not that our net deferred tax assets ~~due to the acquisition. Due to net operating losses, or NOLs, carried forward,~~would not be realizable. At each reporting date, we consider new evidence, both positive and ~~the repeal~~negative, that could affect our view of the ~~corporate minimum~~future realization of deferred tax noassets. As of September 30, 2020, in part because in the current year we achieved three years of cumulative pretax income in the U.S. federal ~~income~~and state tax ~~expense was recorded for 2020 or 2019. The utilization~~jurisdictions and based on our most recent forecasts, we determined that there is sufficient positive evidence to conclude that it is more likely than not that additional deferred taxes of ~~our NOLs has not resulted in any deferred federal tax expense because there was a full valuation allowance recorded with respect to the NOLs. However, if our results of operations continue to improve,~~$124.6 million are realizable and, therefore, we ~~may be required to reverse some or all of~~reduced the valuation allowance onaccordingly. For more information, see Note 14, Income Taxes, to our ~~deferred tax assets in the second half of 2020.~~condensed consolidated financial statements included herein.

Liquidity and Capital Resources

Since our inception in December 2006, we have devoted most of our cash resources to manufacturing, research and development and selling, general and administrative activities related to the development and commercialization of EXPAREL. In addition, we acquired iovera° as part of the MyoScience Acquisition in April 2019. We are highly dependent on the commercial success of EXPAREL, which we launched in April 2012. We have financed our operations primarily with cash generated from product sales, the proceeds from the sale of equity and debt securities, borrowings under prior debt facilities and collaborative licensing and milestone revenue. As of ~~June~~September 30, 2020, we had an accumulated deficit of ~~$398.5~~$268.4 million, cash and cash equivalents, short-term and long-term investments of ~~$335.1~~$576.2 million and working capital of ~~$385.2~~$572.2 million. The net cash proceeds from the July 2020 issuance of $402.5 million aggregate principal of the 2025 Notes was ~~$178.8~~$178.9 million, after deducting fees and ~~estimated~~ offering expenses of ~~$12.6~~$12.5 million and using $211.1 million (including accrued interest) to retire $185.0 million in aggregate principal of our existing 2022 Notes. For more information, see Note ~~17,~~9, ~~Subsequent Events~~Debt, to our condensed consolidated financial statements included herein.

As discussed above, we anticipate that the COVID-19 pandemic will continue to result in a reduction of certain commercial and clinical expenditures which would offset some of the revenue declines caused by the COVID-19 pandemic. We currently expect that our cash, short-term and long-term investments on hand will be adequate to cover any potential short-term liquidity needs, ~~(especially considering the issuance of the 2025 Notes in July 2020),~~ and that we would be able to access other sources of financing should the need arise.

On March 27, 2020, the Coronavirus Aid, Relief and Economic Security (CARES) Act was signed into law in response to the COVID-19 pandemic. The CARES Act, among other things, allows for certain measures to increase liquidity for businesses such as the deferral of employer payroll taxes, a tax credit for retaining employees and other provisions. We ~~are continuing to evaluate the overall impact of the CARES Act on our business. We~~ currently expect to benefit from the provision to defer the payment of certain employer payroll taxes of approximately ~~$3.8~~$3.3 million for calendar year 2020, of which ~~$1.2~~$2.2 million has been deferred as of ~~June~~September 30, 2020. ~~Half~~One-half of these deferrals are due at each of December 31, 2021 and December 31, ~~2022, respectively.~~2022.

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Summary of Cash Flows

The following table summarizes our cash flows from operating, investing and financing activities for the periods indicated (in thousands):

Six Months Ended
June 30,
Condensed Consolidated Statement of Cash Flows Data: 2020 2019
Net cash provided by (used in):
Operating activities $ (9,416) $ 26,262
Investing activities 7,557 (103,318)
Financing activities 2,183 4,267
Net increase (decrease) in cash and cash equivalents $ 324 $ (72,789)

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	Nine Months Ended September 30,
Condensed Consolidated Statements of Cash Flows Data:	2020		2019
Net cash provided by (used in):
Operating activities	$	30,365	$	44,616
Investing activities	(195,290)		(97,693)
Financing activities	211,941		5,690
Net increase (decrease) in cash and cash equivalents	$	47,016	$	(47,387)

Operating Activities

During the ~~six~~nine months ended ~~June~~September 30, 2020, net cash ~~used in operating activities was $9.4 million, compared to $26.3 million~~ provided by operating activities was $30.4 million, compared to $44.6 million during the ~~six~~nine months ended ~~June~~September 30, 2019. The decrease of ~~$35.7~~$14.3 million was primarily attributable to ~~an 8% decrease in net product sales of EXPAREL caused by the COVID-19 pandemic and~~ contingent consideration payments made to MyoScience securityholders—$9.4 million of which was classified as an operating outflow with the remaining $5.6 million classified as a financing outflow. There was also a 1% decrease in net product sales of EXPAREL caused by the COVID-19 pandemic. This decrease also included additional expenditures related to growing a team of account managers focused on the outpatient market for EXPAREL as well as marketing initiatives and customer outreach for iovera°.

Investing Activities

During the ~~six~~nine months ended ~~June~~September 30, 2020, net cash ~~provided by~~used in investing activities was ~~$7.6~~$195.3 million, which reflected ~~$23.2~~$171.9 million of short-term and long-term investment ~~maturities~~purchases (net of ~~purchases)~~maturities) and purchases of fixed assets of ~~$15.6~~$23.4 million. Major fixed asset purchases included equipment for a new EXPAREL capacity expansion project at our Science Center Campus and continuing expenditures for expanding our EXPAREL manufacturing capacity in Swindon, England in partnership with Thermo Fisher.

During the ~~six~~nine months ended ~~June~~September 30, 2019, net cash used in investing activities was ~~$103.3~~$97.7 million, which reflected cash used to fund the MyoScience Acquisition of $118.7 million (net of $1.3 million of cash acquired), purchases of fixed assets of ~~$4.1~~$5.7 million, and an additional $1.6 million investment in TELA Bio, ~~Inc.,~~ partially offset by ~~$21.1~~$28.3 million of short-term and long-term investment maturities (net of purchases). Major fixed asset purchases included continuing expenditures for expanding our EXPAREL manufacturing capacity in Swindon, England ~~in partnership with Thermo Fisher,~~ and facility upgrades at our Science Center ~~Campus.~~Campus in San Diego, California.

Financing Activities

During the ~~six~~nine months ended ~~June~~September 30, 2020, net cash provided by financing activities was ~~$2.2~~$211.9 million, which consisted of gross proceeds from the issuance of the 2025 Notes of $402.5 million, the exercise of stock options of $36.0 million and $1.4 million from the issuance of shares through our ESPP. In conjunction with the issuance of the 2025 Notes, we paid $12.5 million in financing costs and retired $185.0 million in aggregate principal amount of our 2022 Notes in privately-negotiated transactions for a total of $211.1 million of cash (including $1.2 million of accrued interest classified as an operating outflow). We also made $5.6 million of contingent consideration payments to MyoScience securityholders.

During the nine months ended September 30, 2019, net cash provided by financing activities was $5.7 million, which consisted of proceeds from the exercise of stock options of ~~$6.4 million and $1.4 million from the issuance of shares through our ESPP, partially offset by $5.6 million of contingent consideration payments made to MyoScience securityholders.~~

~~During the six months ended June 30, 2019, net cash provided by financing activities was $4.3 million, which consisted of proceeds from the exercise of stock options of $3.6~~$5.0 million and $1.3 million from the issuance of shares through our ESPP, partially offset by $0.6 million of payments made to retire our 3.25% convertible senior notes due 2019.

2025 Convertible Senior Notes

On July 10, 2020, we completed a private placement of $402.5 million in aggregate principal amount of our 2025 Notes and entered into an indenture, or 2025 Indenture, with respect to the 2025 Notes. The 2025 Notes accrue interest at a fixed rate of ~~0.75%~~0.750% per annum, payable in arrears on February 1 and August 1 of each year, beginning on February 1, 2021. The 2025 Notes mature on August 1, 2025. At September 30, 2020, the outstanding principal on the 2025 Notes was $402.5 million.

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On or after February 3, 2025, until the close of business on the second scheduled trading day immediately preceding August 1, 2025, holders may convert their 2025 Notes at any time. Upon conversion, holders will receive the principal amount of their 2025 Notes and any excess conversion value. For both the principal and excess conversion value, holders may receive cash, shares of our common stock or a combination of cash and shares of our common stock, at our option. The initial conversion rate for the 2025 Notes is 13.9324 shares of common stock per $1,000 principal amount, which is equivalent to an initial conversion price of approximately $71.78 per share of our common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest.

Prior to the close of business on the business day immediately preceding February 3, 2025, holders may convert the 2025 Notes under certain circumstances, including if during any given calendar quarter, our stock price closes at or above 130% of the conversion price then applicable during a period of at least 20 out of the last 30 consecutive trading days of the previous quarter.

While the 2025 Notes are currently classified on our consolidated balance sheet at September 30, 2020 as long-term debt, the future convertibility and resulting balance sheet classification of this liability will be monitored at each quarterly reporting date and will be analyzed dependent upon market prices of our common stock during the prescribed measurement periods. In the event that the holders of the 2025 Notes have the right to convert the 2025 Notes at any time during the prescribed measurement period, the 2025 Notes would then be considered a current obligation and classified as such.

On or after August 1, 2023, we may redeem for cash, shares of our common stock or a combination of cash and shares of our common stock, at our option, all or part of the 2025 Notes if the last reported sale price (as defined in the 2025 Indenture) of our common stock has been at least 130% of the conversion price then in effect for at least 20 trading days (whether or not

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consecutive) during any 30 consecutive trading-day period ending within five trading days prior to the date on which we provide notice of redemption. This condition was not met during the quarter ended September 30, 2020.

See Note ~~17,~~9, ~~Subsequent Events~~Debt, to our condensed consolidated financial statements included herein for further discussion of the 2025 Notes.

2022 Convertible Senior Notes

On March 13, 2017, we completed a private placement of $345.0 million in aggregate principal amount of our 2022 Notes, and entered into an indenture, or 2022 Indenture, with respect to the 2022 Notes. The 2022 Notes accrue interest at a fixed rate of 2.375% per annum, payable semiannually in arrears on April 1 and October 1 of each year. The 2022 Notes mature on April 1, 2022. At ~~June~~September 30, 2020, the outstanding principal on the 2022 Notes was ~~$345.0~~$160.0 million. In July 2020, we used part of the net proceeds from the issuance of the 2025 Notes discussed above to repurchase $185.0 million aggregate principal of the 2022 Notes in privately-negotiated transactions for an aggregate of approximately $211.1 million in cash, including accrued ~~interest, reducing the current outstanding principal on the 2022 Notes to $160.0 million.~~interest.

On or after October 1, 2021, until the close of business on the second scheduled trading day immediately preceding April 1, 2022, holders may convert their 2022 Notes at any time. Upon conversion, holders will receive the principal amount of their 2022 Notes and any excess conversion value. For both the principal and excess conversion value, holders may receive cash, shares of our common stock or a combination of cash and shares of our common stock, at our option. The initial conversion rate for the 2022 Notes is 14.9491 shares of common stock per $1,000 principal amount, which is equivalent to an initial conversion price of approximately $66.89 per share of our common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest.

Prior to the close of business on the business day immediately preceding October 1, 2021, holders may convert the 2022 Notes under certain circumstances, including if during any given calendar quarter, our stock price closes at or above 130% of the conversion price then applicable during a period of at least 20 out of the last 30 consecutive trading days of the previous quarter.

While the 2022 Notes are currently classified on our consolidated balance sheet at ~~June~~September 30, 2020 as long-term debt, the future convertibility and resulting balance sheet classification of this liability will be monitored at each quarterly reporting date and will be analyzed dependent upon market prices of our common stock during the prescribed measurement periods. In the event that the holders of the 2022 Notes have the right to convert the 2022 Notes at any time during the prescribed measurement period, the 2022 Notes would then be considered a current obligation and classified as such.

As of April 1, 2020, we may redeem for cash, shares of our common stock or a combination of cash and shares of our common stock, at our option, all or part of the 2022 Notes if the last reported sale price (as defined in the 2022 Indenture) of

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our common stock has been at least 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading-day period ending within five trading days prior to the date on which we provide notice of redemption. This condition was not met during the quarter ended ~~June~~September 30, 2020.

See Note 9, Debt, to our condensed consolidated financial statements included herein for further discussion of the 2022 Notes.

Future Capital Requirements

We believe that our existing cash and cash equivalents, short-term and long-term investments and cash received from product sales will be sufficient to enable us to fund our operating expenses, capital expenditure requirements, payment of the principal on any conversions of our 2022 Notes and 2025 Notes, and to service our indebtedness through at least ~~August 6,~~October 29, 2021. Our future use of operating cash and capital requirements will depend on many forward-looking factors, including, but not limited to, the following:

•the impact of the COVID-19 pandemic, including the amounts and delays of suspended surgical procedures, clinical trials and general economic conditions;

•our ability to successfully continue to expand the commercialization of EXPAREL, including outside of the U.S.;

•the costs of expanding the commercialization of iovera°, including outside of the U.S.;

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•the cost and timing of expanding our manufacturing facilities for EXPAREL and other product candidates, including the construction of an additional manufacturing suite at Thermo Fisher’s facility in Swindon, England and an EXPAREL capacity expansion project at our Science Center ~~Campus;~~Campus in San Diego, California;

•the cost and timing of potential remaining milestone payments to MyoScience security holders, which could be up to an aggregate of $58.0 million if certain regulatory and commercial milestones are met;

•the cost and timing of potential milestone payments to Skyepharma, which could be up to an aggregate of $36.0 million if certain milestones pertaining to net sales of DepoBupivacaine products, including EXPAREL, are met, or upon the first commercial sale in the United Kingdom, France, Germany, Italy or Spain;

•the cost and timing of an early termination payment to DePuy Synthes, which we currently estimate to be up to $12.0 million;

•the timing of and extent to which the holders of our 2022 Notes and 2025 Notes elect to convert their notes;

•costs related to legal and regulatory issues;

•the costs of performing additional clinical trials for EXPAREL, including the pediatric trials required by the FDA as a condition of approval;

•the costs of performing additional clinical trials for iovera°;

•the costs for the development and commercialization of other product candidates; and

•the extent to which we acquire or invest in products, businesses and technologies.

We may require additional debt or equity financing to meet our future operating and capital requirements. We have no committed external sources of funds, and additional equity or debt financing may not be available on acceptable terms, if at all. In particular, capital market disruptions or negative economic conditions, especially in light of the COVID-19 pandemic, may hinder our access to capital.

Off-Balance Sheet Arrangements

We do not have any material off-balance sheet arrangements as of ~~June~~September 30, 2020, nor do we have any relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities.

Critical Accounting Policies and Use of Estimates

See Note 2, Summary of Significant Accounting Policies, to our condensed consolidated financial statements included herein for a discussion of recently issued accounting pronouncements and their impact or future potential impact on our

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financial results, if determinable. For a description of critical accounting policies that affect our significant judgments and estimates used in the preparation of our consolidated financial statements, refer to our most recent Annual Report on Form 10-K for the year ended December 31, 2019.

Income Taxes

Through June 30, 2020, we had established a valuation allowance to reduce our deferred tax assets to amounts expected to be realized. The primary basis for the valuation allowance had been our historical losses. However, in in the current year, we achieved three years of cumulative pretax income in the U.S. federal and state tax jurisdictions. We have been demonstrating strong earnings from our core business, after taking into account any unusual, non-recurring items not expected to occur in future periods. Based on our most recent forecasts, we expect these improvements to continue into future periods. We have also considered the timing in which existing temporary differences will reverse in future periods. Based on the positive evidence of projections of future taxable income and forecasts of future pre-tax book income, we have concluded it is more likely than not that we will realize the future benefits of our U.S. deferred tax assets. As a result, we recorded an income tax benefit of $124.6 million due to the reversal of our valuation allowance relating to our U.S. federal net deferred tax assets during the third quarter of 2020. For more information, see Note 14, Income Taxes, to our condensed consolidated financial statements included herein.

Contractual Obligations

Other than the issuance of $402.5 million of aggregate principal of our 2025 Notes and concurrent repurchase of $185.0 million aggregate principal of our 2022 Notes in July 2020 discussed above, there have been no material changes in our contractual obligations relating to our indebtedness, lease obligations and purchase obligations from those reported in our Annual Report on Form 10-K for the year ended December 31, 2019. For more information on our contractual obligations and commercial commitments, see Part II, Item 7 in our Annual Report on Form 10-K for the year ended December 31, 2019.

Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

The primary objective of our cash equivalents and investment activities is to preserve principal while at the same time maximizing the income that we receive from our investments without significantly increasing risk. We invest in corporate bonds, commercial paper, ~~and~~ asset-backed securities and U.S. Treasury notes, which are reported at fair value. These securities are subject to interest rate risk and credit risk. This means that a change in prevailing interest rates may cause the principal amount of the investment to fluctuate. For example, if we hold a security that was issued with a fixed interest rate at the then-prevailing rate and the interest rate later rises, we expect that the fair value of our investment will decline. A hypothetical 100 basis point increase in

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interest rates would have reduced the fair value of our available-for-sale securities at ~~June~~September 30, 2020 by approximately ~~$1.1~~$2.1 million.

We have an equity investment in the common stock of TELA Bio (traded on the Nasdaq Global Select Market under the ticker symbol “TELA”). Changes in the stock price of TELA Bio will affect the value of our investment, and we could incur realized or unrealized losses on all or a part of the value of this investment. At ~~June~~September 30, 2020, the value of our investment in TELA Bio was ~~$10.0~~$12.8 million, and a hypothetical 10% decrease in the market price of TELA Bio stock would have caused a decrease in our carrying amount by ~~$1.0~~$1.3 million. See Note 10, Financial Instruments, to our condensed consolidated financial statements included herein for additional information on our investment in TELA Bio.

In July 2020, we issued $402.5 million in aggregate principal amount of our 2025 Notes, which mature in August 2025. Holders may convert their 2025 Notes prior to maturity under certain circumstances. Upon conversion, holders will receive the principal amount of the 2025 Notes and any excess conversion value in cash, shares of our common stock or a combination of cash and shares, at our option. The fair value of the 2025 Notes is impacted by both the fair value of our common stock and interest rate fluctuations. As of September 30, 2020, the estimated fair value of the 2025 Notes was $1,096 per $1,000 principal amount. See Note ~~17,~~9, ~~Subsequent Events~~Debt, to our condensed consolidated financial statements included herein for further discussion of the 2025 Notes. The 2025 Notes bear interest at a fixed rate. At September 30, 2020, all $402.5 million of principal remains outstanding on the 2025 Notes.

In March 2017, we issued $345.0 million in aggregate principal amount of our 2022 Notes, which mature in April 2022. In July 2020, we used part of the net proceeds from the issuance of the 2025 Notes discussed above to repurchase $185.0 million aggregate principal of the 2022 Notes in privately-negotiated transactions for an aggregate of approximately $211.1 million in cash, including accrued interest. Holders may convert their 2022 Notes prior to maturity under certain circumstances. Upon conversion, holders will receive the principal amount of the 2022 Notes and any excess conversion value in cash, shares of our common stock or a combination of cash and shares, at our option. The fair value of the 2022 Notes is impacted by both the fair value of our common stock and interest rate fluctuations. The 2022 Notes bear interest at a fixed rate. As

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of September 30, 2020, the estimated fair value of the 2022 Notes was ~~$1,096~~$1,149 per $1,000 principal amount. See Note 9, Debt, to our condensed consolidated financial statements included herein for further discussion of the 2022 Notes. At ~~June~~September 30, 2020, ~~all $345.0~~$160.0 million of principal ~~remained~~remains outstanding on ~~the 2022 Notes, which was subsequently reduced to $160.0 million after the July 2020 repurchase of $185.0 million aggregate principal of~~ the 2022 Notes.

Additionally, our accounts receivable are primarily concentrated with three large wholesalers of pharmaceutical products. In the event of non-performance or non-payment, there may be a material adverse impact on our financial condition, results of operations or net cash flow.

Item 4. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

As required by Rule 13a-15(b) under the Exchange Act, our management, including our Chief Executive Officer and Chairman and our Chief Financial Officer, conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this report. As defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, disclosure controls and procedures are controls and other procedures which are designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is accumulated and communicated to our management, including our Chief Executive Officer and Chairman and our Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

Based on that evaluation, our Chief Executive Officer and Chairman and our Chief Financial Officer concluded that our disclosure controls and procedures were effective as of ~~June~~September 30, 2020.

Changes in Internal Control over Financial Reporting

During the quarter ended ~~June~~September 30, 2020, our management has integrated internal controls for the acquired MyoScience business into our existing controls. Other than the controls enhanced or implemented to integrate the MyoScience business, there have been no changes in our internal control over financial reporting that occurred during the quarter ended ~~June~~September 30, 2020 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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Inherent Limitations on Effectiveness of Controls

Our management, including the Chief Executive Officer and Chairman and our Chief Financial Officer, does not expect that our disclosure controls or our internal control over financial reporting will prevent or detect all errors and all fraud. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. The design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Further, because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, within our company have been detected. These inherent limitations include the realities that judgments in decision-making can be faulty and that breakdowns can occur because of simple error or mistake. Controls can also be circumvented by the individual acts of some persons, by collusion of two or more people or by management override of the controls. The design of any system of controls is based in part on certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Projections of any evaluation of controls effectiveness to future periods are subject to risks. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with policies or procedures.

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PART II — OTHER INFORMATION

Item 1. LEGAL PROCEEDINGS

From time to time, we have been and may again become involved in legal proceedings arising in the ordinary course of our business. WeExcept as described below, we are not presently a party to any litigation or legal proceedings that we believe to be material and we are not aware of any pending or threatened litigation against us that we believe could have a material adverse effect on our business, operating results, financial condition or cash flows.

MyoScience Milestone Litigation

In August 2020, we and our subsidiary, Pacira CryoTech, Inc. (“Pacira CryoTech”), filed a lawsuit in the Court of Chancery of the State of Delaware against Fortis Advisors LLC (“Fortis”), solely in its capacity as representative for the former securityholders of MyoScience, and certain other defendants, seeking declaratory judgment with respect to certain terms of the merger agreement for the MyoScience Acquisition (the “Merger Agreement”), specifically related to the achievement of certain milestone payments under the Merger Agreement. In addition, we and Pacira CryoTech sought general, special and compensatory damages against the other defendants related to breach of fiduciary duties in connection with the purported achievement of milestone payments under the Merger Agreement, and breach of the Merger Agreement and certain other agreements with the defendants. In October 2020, Fortis filed an answer and counterclaim against us and Pacira CryoTech seeking to recover certain milestone payments under the Merger Agreement totaling $40.0 million, and attorneys’ fees. We believe that the counterclaim from Fortis is without merit and intend to vigorously defend against all claims. We are unable to predict the outcome of this action at this time.

Department of Justice Inquiry Settlement

In April 2015, we received a subpoena from the U.S. Department of Justice, U.S. Attorney’s Office for the District of New Jersey pertaining to marketing and promotional practices related to EXPAREL. In July 2020, we formally entered into settlement agreements that resolved all outstanding investigations and claims by the U.S. Department of Justice, the United States Department of Health and Human Services, various States Attorneys’ General and a private plaintiff. This agreement concludes a five-year investigation related to the sale and marketing of EXPAREL. Under the various settlement agreements, we paid a global settlement of $3.5 million, which was previously recorded in acquisition-related charges, product discontinuation and other in the consolidated financial statements for the year ended December 31, 2019. We expressly deny all allegations and contentions and have admitted no wrongdoing in connection with the settlement agreements. We have been given assurances that this concludes the investigation that originated from the U.S. Department of Justice subpoena in April 2015.

Item 1A. RISK FACTORS

You should carefully consider the factors discussed in Part I, Item 1A. “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2019, which could materially affect our business, financial condition, cash flows or future results. Except as set forth below, there have been no material changes in our risk factors included in our Annual Report on Form 10-K for the year ended December 31, 2019. The risks described in our Annual Report on Form 10-K for the year ended December 31, 2019 and those set forth below are not the only risks facing our company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition or future results.

A pandemic, epidemic or outbreak of a contagious disease (such as the novel coronavirus (COVID-19) pandemic), or fear of such an event, could have a material adverse effect on our business, operating results and financial condition.

A pandemic, epidemic or outbreak of an infectious disease, including the current COVID-19 pandemic, or other public health crisis, could have a material adverse effect on our business, financial condition and operations, including but not limited to our revenue and cash flows, including potential decreases in sales, manufacturing issues, supply issues and delays in payments by our customers. For example, as a result of the COVID-19 pandemic, elective surgeries were suspended in many jurisdictions, and while elective surgery restrictions have lifted in most states beginning in April of 2020, we do not know if, and how, future restrictions may affect the surgical communities’ return to, or redefining of, normal operations, whether due to governmental restrictions, institutional, patient or clinical decisions or general economic conditions. A prolonged suspension of

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elective surgeries by governmental restrictions or action would cause net sales of our products to decrease, including if and when states resume shutdowns or restrict elective surgical procedures again. In addition, due to health concerns from the

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COVID-19 pandemic or negative economic conditions, patients and clinicians could cancel or defer elective procedures or otherwise avoid medical treatment, which would result in reduced patient volumes and revenues, which could potentially continue over an extended period of time.

Business disruptions could include disruptions or restrictions to our workforce, including the ability of our sales teams to interact with our customers and healthcare professionals to educate them on the benefits of our products and perform typical sales activities. For example, the ongoing COVID-19 pandemic had significantly impacted the ability of our sales representatives to access customers and healthcare professionals through personal interactions within the healthcare setting, including hospitals and ambulatory surgical centers. With the reopening of many states, the ability of our sales representatives to renew their in-person engagement efforts, in conjunction with remote efforts, has occurred across all sites of care, with more focus on physician offices and ambulatory surgical centers. However, we are unable to predict if such in-person engagement will continue as the pandemic persists. In addition, any temporary closures of our manufacturing facilities or the facilities of our suppliers and contract manufacturers (and the resulting impact on production or our products) or the workforce at such facilities, could cause delays in the shipment or production of our products. We may also face delays if our suppliers have to extend our lead times for raw materials and/or are not able to supply us with adequate quantities needed for production. If our customers experience disruptions to their businesses and cash flows, we could experience delays or difficulties with the collection of our accounts receivable. Any sustained impacts and business disruptions to our facilities or workforce, our customers, our suppliers, or our contract manufacturers would likely adversely impact our cash flows, sales and operating results.

Ultimately, the extent to which COVID-19 or other public health crises could continue to impact our business is difficult to predict and will depend on many factors beyond our control, including the speed of contagion, the development and implementation of effective preventative measures and possible treatments, the scope of governmental and other restrictions on elective surgeries, travel and other activity through quarantines/social distancing and other measures, public reactions to these factors and more.

The extent to which COVID-19 impacts our business, revenues and results of operations will depend on future developments, which are highly uncertain, constantly changing and cannot be predicted. This includes new information that may emerge concerning the severity of COVID-19, the spread and proliferation of COVID-19 around the world, the duration of the outbreak and the actions taken to contain COVID-19 or treat its impact, among others.

Item 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

Item 3. DEFAULTS UPON SENIOR SECURITIES

None.

Item 4. MINE SAFETY DISCLOSURES

Not applicable.

Item 5. OTHER INFORMATION

Not applicable.

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Item 6. EXHIBITS

The exhibits listed below are filed or furnished as part of this report.


Exhibit Number						Description
~~10.1~~4.1						~~Pacira BioSciences, Inc. Deferred Compensation Plan.~~Indenture, dated as of July 10, 2020, by and between the Company and Wells Fargo Bank, National Association.(1)†

4.2						Form of Global 0.750% Convertible Senior Note due 2025.(1)

31.1						Certification of Chief Executive Officer and Chairman pursuant to Rule 13a-14(a) and 15d-14(a), as amended.*

31.2						Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as amended.*

32.1						Certification of Chief Executive Officer and Chairman and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.**

101						The following materials from the Quarterly Report on Form 10-Q of Pacira BioSciences, Inc. for the quarter ended ~~June~~September 30, 2020, formatted in iXBRL (Inline eXtensible Business Reporting Language): (i) the Condensed Consolidated Balance Sheets; (ii) the Condensed Consolidated Statements of Operations; (iii) the Condensed Consolidated Statements of Comprehensive Income (Loss); (iv) the Condensed Consolidated Statements of Stockholders’ Equity; (v) the Condensed Consolidated Statements of Cash Flows; and (vi) the Condensed Notes to Consolidated Financial Statements.*

104						Cover Page Interactive Data File (Formatted as Inline XBRL and contained in Exhibit 101).

* Filed herewith.

** Furnished herewith.

~~† Denotes management contract or compensatory plan or arrangement~~

(1) Incorporated by reference ~~to Exhibit 10.1~~ to the Registrant’s Current Report on Form 8-K, filed on ~~June 11, 2020.~~July 10, 2020

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.


		PACIRA BIOSCIENCES, INC. (REGISTRANT)

Dated:	~~August 6,~~October 29, 2020	/s/ DAVID STACK
		David Stack
		Chief Executive Officer and Chairman
		(Principal Executive Officer)

Dated:	~~August 6,~~October 29, 2020	/s/ CHARLES A. REINHART, III
		Charles A. Reinhart, III
		Chief Financial Officer
		(Principal Financial Officer)

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	Three Months Ended June 30, 2019		Six Months Ended June 30, 2019
Total revenues	$	102,913	$	196,366
Net income (loss)	$	4,234	$	(4,742)
Pro forma basic and diluted net income (loss) loss per share	$	0.10	$	(0.11)


June 30, 2020 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)
Short-term:
Asset-backed securities	$	61,567	$	471	$	—	$	62,038
Commercial paper	15,472		22		—		15,494
Corporate bonds	169,767		941		—		170,708
Subtotal	246,806		1,434		—		248,240
Long-term:

Corporate bonds	8,205		56		—		8,261
Subtotal	8,205		56		—		8,261
Total	$	255,011	$	1,490	$	—	$	256,501


	Six Months Ended June 30,
Condensed Consolidated Statement of Cash Flows Data:	2020		2019
Net cash provided by (used in):
Operating activities	$	(9,416)	$	26,262
Investing activities	7,557		(103,318)
Financing activities	2,183		4,267
Net increase (decrease) in cash and cash equivalents	$	324	$	(72,789)