UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

~~FORM 10-Q~~

(Mark One)

☒	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended ~~March 31,~~June 30, 2021

☐	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission file number 001-32587

ALTIMMUNE, INC.

~~ALTIMMUNE, INC.~~

(Exact Name of Registrant as Specified in its Charter)


Delaware		20-2726770
(State or Other Jurisdiction of Incorporation or Organization)		(I.R.S. Employer Identification No.)

910 Clopper RoadSuite 201S, Gaithersburg, Maryland		20878
(Address of Principal Executive Offices)		(Zip Code)

~~(240)~~ (240) 654-1450

(Registrant’s Telephone Number, Including Area Code)

Securities registered pursuant to Section 12(b) of the Act:


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common stock, par value $0.0001 per share	ALT	The NASDAQ Global Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒⌧ No ☐◻

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒⌧ No ☐◻

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.


Large accelerated filer	☐◻	Accelerated filer	☐◻
Non-accelerated filer	☒⌧	Smaller reporting company	☒⌧
		Emerging growth company	☐◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐◻

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒⌧

As of ~~May 14,~~August 6, 2021 there were ~~38,396,843~~39,705,884 shares of the registrant’s common stock, par value $0.0001 per share, outstanding.

Table of Contents

PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

ALTIMMUNE, INC.

CONSOLIDATED BALANCE SHEETS


	June 30,		December 31,
	2021		2020
	(unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	174,102,382	$	115,917,807
Restricted cash		34,174		34,174
Total cash, cash equivalents and restricted cash		174,136,556		115,951,981
Short-term investments		43,723,840		100,005,558
Accounts receivable		4,463,442		4,610,202
Tax refund receivable		6,887,981		7,762,793
Prepaid expenses and other current assets		9,413,070		1,926,675
Total current assets		238,624,889		230,257,209
Property and equipment, net		4,751,010		1,056,920
Intangible assets, net		12,956,112		12,823,846
Other assets		928,839		977,238
Total assets	$	257,260,850	$	245,115,213
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	1,421,192	$	612,293
Accrued expenses and other current liabilities		7,674,536		11,408,154
Total current liabilities		9,095,728		12,020,447
Contingent consideration		5,270,000		5,390,000
Other long-term liabilities		1,617,150		1,828,443
Total liabilities		15,982,878		19,238,890
Commitments and contingencies (Note 16)
Stockholders’ equity:
Common stock, $0.0001 par value; 200,000,000 shares authorized; 39,693,524 and 37,142,946 shares issued and outstanding at June 30, 2021 and December 31, 2020, respectively		3,956		3,697
Additional paid-in capital		482,083,670		417,337,742
Accumulated deficit		(235,771,414)		(186,420,599)
Accumulated other comprehensive loss, net		(5,038,240)		(5,044,517)
Total stockholders’ equity		241,277,972		225,876,323
Total liabilities and stockholders’ equity	$	257,260,850	$	245,115,213

March 31, 2021

December 31, 2020

(unaudited)

ASSETS

Current assets:

Cash and cash equivalents

$
149,932,387

$
115,917,807

Restricted cash

34,174

34,174

Total cash, cash equivalents and restricted cash

149,966,561

115,951,981

Short-term investments

76,574,768

100,005,558

Accounts receivable

4,801,428

4,610,202

Tax refund receivable

7,898,067

7,762,793

Prepaid expenses and other current assets

5,950,999

1,926,675

Total current assets

245,191,823

230,257,209

Property and equipment, net

5,198,052

1,056,920

Right of use asset

866,336

903,825

Intangible assets, net

12,879,247

12,823,846

Other assets

115,300

73,413

Total assets

$
264,250,758

$
245,115,213

LIABILITIES AND STOCKHOLDERS’ EQUITY

Current liabilities:

Accounts payable

$
418,243

$
612,293

Accrued expenses and other current liabilities

9,405,649

11,408,154

Total current liabilities

9,823,892

12,020,447

Contingent consideration

6,270,000

5,390,000

Other long-term liabilities

1,719,438

1,828,443

Total liabilities

17,813,330

19,238,890

Commitments and contingencies (Note 16)

Stockholders’ equity:

Common stock, $0.0001 par value; 200,000,000 shares authorized;
38,257,180 and 37,142,946 shares issued and outstanding at March 31, 2021 and December 31, 2020, respectively

3,810

3,697

Additional paid-in capital

462,417,706

417,337,742

Accumulated deficit

(210,944,707
)

(186,420,599
)
Accumulated other comprehensive loss, net

(5,039,381
)

(5,044,517
)
Total stockholders’ equity

246,437,428

225,876,323

Total liabilities and stockholders’ equity

$
264,250,758

$
245,115,213

The accompanying notes are an integral part of the unaudited consolidated financial statements.

Table of Contents

ALTIMMUNE, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

(unaudited)


	For the Three Months Ended				For the Six Months Ended
	June 30,				June 30,
	2021		2020		2021		2020
Revenues	$	137,623	$	721,636	$	975,139	$	2,934,330
Operating expenses:
Research and development		13,272,412		16,594,250		25,150,312		23,781,781
General and administrative		3,658,653		2,545,356		7,480,073		4,877,273
Impairment loss on construction-in-progress		8,070,000		—		8,070,000		—
Total operating expenses		25,001,065		19,139,606		40,700,385		28,659,054
Loss from operations		(24,863,442)		(18,417,970)		(39,725,246)		(25,724,724)
Other income (expense):
Interest expense		(22,226)		(3,308)		(33,897)		(5,193)
Interest income		32,863		81,458		75,362		233,027
Other income (expense), net		26,098		(5,878)		(7,034)		19,664
Total other income, net		36,735		72,272		34,431		247,498
Net loss before income tax benefit		(24,826,707)		(18,345,698)		(39,690,815)		(25,477,226)
Income tax benefit		0		1,578,782		0		4,824,661
Net loss		(24,826,707)		(16,766,916)		(39,690,815)		(20,652,565)
Other comprehensive income (loss) — unrealized gain (loss) on short-term investments		1,141		20,888		6,277		(11,547)
Comprehensive loss	$	(24,825,566)	$	(16,746,028)	$	(39,684,538)	$	(20,664,112)
Net loss per share, basic and diluted	$	(0.60)	$	(0.94)	$	(0.99)	$	(1.25)
Weighted-average common shares outstanding, basic and diluted		41,356,643		17,886,853		40,142,561		16,498,719

For the Three Months Ended
March 31,

2021

2020

Revenues

$
837,516

$
2,212,694

Operating expenses:

Research and development

11,877,900

7,187,531

General and administrative

3,821,420

2,331,917

Total operating expenses

15,699,320

9,519,448

Loss from operations

(14,861,804
)

(7,306,754
)
Other income (expense):

Interest expense

(11,671
)

(1,885
)
Interest income

42,499

151,569

Other (expense) income, net

(33,132
)

25,542

Total other (expense) income, net

(2,304
)

175,226

Net loss before income tax benefit

(14,864,108
)

(7,131,528
)
Income tax benefit

—

3,245,879

Net loss

(14,864,108
)

(3,885,649
)
Other comprehensive income (loss) – unrealized gain (loss) on investments

5,136

(32,435
)
Comprehensive loss

$
(14,858,972
)

$
(3,918,084
)
Net loss per share, basic and diluted

$
(0.38
)

$
(0.26
)
Weighted-average common shares outstanding, basic and diluted

38,914,990

15,110,585

The accompanying notes are an integral part of the unaudited consolidated financial statements.

Table of Contents

ALTIMMUNE, INC.

CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY

(unaudited)


								Accumulated
				Additional				Other		Total
	Common Stock			Paid-In		Accumulated		Comprehensive		Stockholders’
	Shares	Amount		Capital		Deficit		Loss		Equity
Balance at December 31, 2020	37,142,946	$	3,697	$	417,337,742	$	(186,420,599)	$	(5,044,517)	$	225,876,323
Stock-based compensation	—		—		1,218,351		—		—		1,218,351
Vesting of restricted stock awards including withholding, net	(6,349)		1		(92,507)		—		—		(92,506)
Issuance of common stock from Employee Stock Purchase Plan	8,733		1		106,000		—		—		106,001
Retirement of common stock in exchange for common stock warrant	(1,000,000)		(100)		(7,539,900)		(9,660,000)		—		(17,200,000)
Issuance of common stock warrant in exchange for retirement of common stock	—		—		17,200,000		—		—		17,200,000
Issuance of common stock in at the market offerings, net	2,110,800		211		34,178,020		—		—		34,178,231
Issuance of common stock upon cashless exercise of warrants	1,050		—		10,000		—		—		10,000
Unrealized gain on short-term investments	—		—		—		—		5,136		5,136
Net loss	—		—		—		(14,864,108)		—		(14,864,108)
Balance at March 31, 2021	38,257,180		3,810		462,417,706		(210,944,707)		(5,039,381)		246,437,428
Stock based compensation	—		—		1,484,829		—		—		1,484,829
Exercise of stock options	38,217		4		94,425		—		—		94,429
Vesting of restricted stock awards including withholding, net	(7,583)		1		(91,122)		—		—		(91,121)
Issuance of common stock in at the market offerings, net	1,405,710		141		18,177,832		—		—		18,177,973
Unrealized gain on short term investments	—		—		—		—		1,141		1,141
Net loss	—		—		—		(24,826,707)		—		(24,826,707)
Balance at June 30, 2021	39,693,524	$	3,956	$	482,083,670	$	(235,771,414)	$	(5,038,240)	$	241,277,972

Common Stock

Additional
Paid-In

Accumulated

Accumulated
Other
Comprehensive

Total
Stockholders’

Shares

Amount

Capital

Deficit

Loss

Equity

Balance at December 31, 2020

37,142,946

$
3,697

$
417,337,742

$
(186,420,599
)

$
(5,044,517
)

$
225,876,323

Stock-based compensation

—

—

1,218,351

—

—

1,218,351

Vesting of restricted stock awards including withholding, net

(6,349
)

1

(92,507
)

—

—

(92,506
)
Issuance of common stock from Employee Stock Purchase Plan

8,733

1

106,000

—

—

106,001

Retirement of common stock in exchange for common stock warrant

(1,000,000
)

(100
)

(7,539,900
)

(9,660,000
)

—

(17,200,000
)
Issuance of common stock warrant in exchange for retirement of common stock

—

—

17,200,000

—

—

17,200,000

Issuance of common stock in at the market offering, net

2,110,800

211

34,178,020

—

—

34,178,231

Issuance of common stock upon cashless exercise of warrants

1,050

—

10,000

—

—

10,000

Unrealized income on short-term investments

—

—

—

—

5,136

5,136

Net loss

—

—

—

(14,864,108
)

—

(14,864,108
)
Balance at March 31, 2021

38,257,180

$
3,810

$
462,417,706

$
(210,944,707
)

$
(5,039,381
)

$
246,437,428

Common Stock

Additional
Paid-In

Accumulated

Accumulated
Other
Comprehensive

Total
Stockholders’

Shares

Amount

Capital

Deficit

Loss

Equity

Balance at December 31, 2019

15,312,167

$
1,508

$
187,914,916

$
(137,376,122
)

$
(5,020,156
)

$
45,520,146

Stock-based compensation

—

—

214,921

—

—

214,921

Vesting of restricted stock awards including withholding, net

(5,974
)

1

(17,080
)

—

—

(17,079
)
Issuance of common stock from Employee Stock Purchase Plan

38,809

3

56,736

—

—

56,739

Issuance of common stock upon exercise of warrants

14,500

2

39,972

—

—

39,974

Unrealized loss on short-term investments

—

—

—

—

(32,435
)

(32,435
)
Net loss

—

—

—

(3,885,649
)

—

(3,885,649
)
Balance at March 31, 2020

15,359,502

$
1,514

$
188,209,465

$
(141,261,771
)

$
(5,052,591
)

$
41,896,617

The accompanying notes are an integral part of the unaudited consolidated financial statements.

Table of Contents

ALTIMMUNE, INC.

CONSOLIDATED STATEMENTS OF ~~CASH FLOWS~~CHANGES IN STOCKHOLDERS’ EQUITY

(unaudited)


								Accumulated
				Additional				Other		Total
	Common Stock			Paid-In		Accumulated		Comprehensive		Stockholders’
	Shares	Amount		Capital		Deficit		Loss		Equity
Balance at December 31, 2019	15,312,167	$	1,508	$	187,914,916	$	(137,376,122)	$	(5,020,156)	$	45,520,146
Stock-based compensation	—		—		214,921		—		—		214,921
Vesting of restricted stock awards including withholding, net	(5,974)		1		(17,080)		—		—		(17,079)
Issuance of common stock from Employee Stock Purchase Plan	38,809		3		56,736		—		—		56,739
Issuance of common stock upon exercise of warrants	14,500		2		39,972		—		—		39,974
Unrealized loss on short-term investments	—		—		—		—		(32,435)		(32,435)
Net loss	—		—		—		(3,885,649)		—		(3,885,649)
Balance at March 31, 2020	15,359,502		1,514		188,209,465		(141,261,771)		(5,052,591)		41,896,617
Stock based compensation	—		—		330,510		—		—		330,510
Exercise of stock options	13,935		1		36,174		—		—		36,175
Vesting of restricted stock awards including withholding, net	(5,974)		1		(46,390)		—		—		(46,389)
Issuance of common stock in at the market offerings, net	2,965,144		297		22,780,432		—		—		22,780,729
Issuance of common stock upon exercise of warrants	8,221,279		822		31,269,341		—		—		31,270,163
Unrealized gain on short term investments	—		—		—		—		20,888		20,888
Net loss	—		—		—		(16,766,916)		—		(16,766,916)
Balance at June 30, 2020	26,553,886	$	2,635	$	242,579,532	$	(158,028,687)	$	(5,031,703)	$	79,521,777

Three Months Ended March 31,

2021

2020

CASH FLOWS FROM OPERATING ACTIVITIES:

Net loss

$
(14,864,108
)

$
(3,885,649
)
Adjustments to reconcile net loss to net cash used in operating activities:

Change in fair value of contingent consideration liability

880,000

1,750,000

Stock-based compensation expense

1,218,351

214,921

Depreciation and amortization

74,298

73,356

Unrealized losses on foreign currency exchange

33,376

24,939

Changes in operating assets and liabilities:

Accounts receivable

(191,226
)

(973,557
)
Prepaid expenses and other current assets

(4,200,624
)

(214,893
)
Accounts payable

(194,050
)

911,397

Accrued expenses and other liabilities

(2,189,903
)

1,112,718

Tax refund receivable

(135,274
)

(3,360,633
)
Net cash used in operating activities

(19,569,160
)

(4,347,401
)
CASH FLOWS FROM INVESTING ACTIVITIES:

Proceeds from sales and maturities of short-term investments

30,912,000

13,700,000

Purchases of short-term investments

(7,476,074
)

(7,099,263
)
Purchases of property and equipment, net

(4,208,790
)

(18,131
)
Cash paid for internally developed patents

(62,041
)

(19,390
)
Net cash provided by investing activities

19,165,095

6,563,216

CASH FLOWS FROM FINANCING ACTIVITIES:

Payments of deferred offering costs

134,413

—

Proceeds from exercises of warrants

—

39,974

Proceeds from issuance of common stock in at the market offering, net

34,178,231

—

Proceeds from issuance of common stock from Employee Stock Purchase Plan

106,001

56,739

Net cash provided by financing activities

34,418,645

96,713

Net increase in cash and cash equivalents and restricted cash

34,014,580

2,312,528

Cash, cash equivalents and restricted cash at beginning of period

115,951,981

8,996,860

Cash, cash equivalents and restricted cash at end of period

$
149,966,561

$
11,309,388

SUPPLEMENTAL NON-CASH FINANCING ACTIVITIES:

Fair value of common stock retired in exchange for issuance of common stock warrant

$
17,200,000

$
—

The accompanying notes are an integral part of the unaudited consolidated financial statements.

Table of Contents

ALTIMMUNE, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(unaudited)


	Six Months Ended June 30,
	2021		2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$	(39,690,815)	$	(20,652,565)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value of contingent consideration liability		(120,000)		13,640,000
Impairment loss on construction-in-progress		8,070,000		—
Stock-based compensation expense		2,703,180		545,431
Depreciation and amortization		149,388		146,045
Unrealized losses (gains) on foreign currency exchange		10,108		(18,851)
Changes in operating assets and liabilities:
Accounts receivable		(93,672)		(160,920)
Prepaid expenses and other current assets		(7,155,593)		(343,337)
Accounts payable		808,899		176,985
Accrued expenses and other liabilities		(4,052,095)		26,761
Tax refund receivable		874,812		(4,877,851)
Net cash used in operating activities		(38,495,788)		(11,518,302)
CASH FLOWS FROM INVESTING ACTIVITIES:
Proceeds from sales and maturities of short-term investments		63,712,000		24,900,000
Purchases of short-term investments		(7,424,005)		(12,118,563)
Purchases of property and equipment, net		(11,900,198)		(40,601)
Cash paid for internally developed patents		(145,546)		(79,336)
Net cash provided by investing activities		44,242,251		12,661,500
CASH FLOWS FROM FINANCING ACTIVITIES:
Payments of deferred offering costs		(118,522)		(179,743)
Proceeds from exercises of warrants		—		31,310,137
Proceeds from issuance of common stock in at the market offerings, net		52,356,204		22,780,729
Proceeds from issuance of notes payable		—		632,000
Proceeds from issuance of common stock from Employee Stock Purchase Plan		106,001		56,739
Proceeds from exercises of stock options		94,429		36,175
Net cash provided by financing activities		52,438,112		54,636,037
Net increase in cash and cash equivalents and restricted cash		58,184,575		55,779,235
Cash, cash equivalents and restricted cash at beginning of period		115,951,981		8,996,860
Cash, cash equivalents and restricted cash at end of period	$	174,136,556	$	64,776,095

The accompanying notes are an integral part of the unaudited consolidated financial statements.

Table of Contents

ALTIMMUNE, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(unaudited)

1. Nature of Business and Basis of Presentation

Nature of Business

Altimmune, Inc., headquartered in Gaithersburg, Maryland, United States, together with its subsidiaries (collectively, the “Company” or ~~“Altimmune��~~“Altimmune”) is a clinical stage biopharmaceutical company incorporated under the laws of the State of Delaware.

The Company is focused on developing ~~intranasal vaccines, immune modulating therapies, and~~ treatments for obesity and liver ~~disease.~~diseases. The Company’s ~~diverse~~ pipeline includes next generation peptide therapeutics for obesity, NASH (ALT-801) and chronic hepatitis B (HepTcell); proprietary intranasal ~~vaccines for COVID-19 (AdCOVID), anthrax (NasoShield)~~vaccines; and ~~influenza (NasoVAX);~~ an intranasal immune modulating therapeutic for ~~COVID-19~~the coronavirus disease (“COVID 19”) (T-COVID)~~; and next generation peptide therapeutics for NASH (ALT-801) and chronic hepatitis B (HepTcell)~~. Since its inception, the Company has devoted substantially all of its efforts to business planning, research and development, recruiting management and technical staff, and raising capital, and has financed its operations through the issuance of common and preferred stock, long-term debt, and proceeds from research grants and government contracts. The Company has not generated any revenues from the sale of any products to date, and there is no assurance of any future revenues from product sales.

On June 29, 2021, the Company announced the discontinuation of the development program for the COVID-19 vaccine candidate, AdCOVID following the Company’s review of findings from the Phase 1 clinical trial, and in view of the highly competitive COVID-19 landscape. The Company is currently evaluating options for the future development of T-COVID as a result of enrollment challenges due to the effective rollout in the United States of authorized COVID-19 vaccines and decreasing incidence of the disease.

Basis of Presentation

The accompanying unaudited consolidated financial statements are prepared pursuant to the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”) regarding interim financial reporting. Accordingly, they do not include all of the information and disclosures required by accounting principles generally accepted in the United States (“U.S. GAAP”) for complete consolidated financial statements and should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2020 included in the Annual Report on Form 10-K which was filed with the SEC on February 25, 2021. In the opinion of management, the Company has prepared the accompanying unaudited consolidated financial statements on the same basis as the audited consolidated financial statements, and these consolidated financial statements include all adjustments, consisting only of normal recurring adjustments, necessary for a fair presentation of the results of the interim periods presented. The operating results for the interim periods presented are not necessarily indicative of the results expected for the full year 2021 or any future years or periods.

The accompanying unaudited consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All significant intercompany accounts and transactions have been eliminated in consolidation.

The accompanying unaudited consolidated financial statements have been prepared on the basis of continuity of operations, realization of assets, and the satisfaction of liabilities in the ordinary course of business. The financial statements do not include any adjustments relating to the recoverability and classification of recorded assets and liabilities that might be necessary should we be unable to continue as a going concern.

2. Summary of Significant Accounting Policies

During the ~~three~~six months ended ~~March 31,~~June 30, 2021, there have been no significant changes to the Company’s summary of significant accounting policies contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2020 as filed with the SEC, except for the recently adopted accounting standard for income taxes.

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Use of Estimates

The preparation of these financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The extent to which the COVID-19 pandemic may directly or indirectly impact the Company’s business, financial condition, and results of operations is highly uncertain and subject to change. The Company considered the potential impact of the COVID-19 pandemic on the Company’s estimates and assumptions and determined that there was not a material impact to the Company’s unaudited consolidated financial statements as of and for the three and six months ended ~~March 31,~~June 30, 2021. However, actual results could differ from those estimates and there may be changes to the Company’s estimates in future periods.

Recently Issued Accounting Pronouncements - Adopted

In December 2019, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2019-12, Income Taxes (Topic 740), Simplifying the Accounting for Income Taxes (“ASU No. 2019-12”). ASU 2019-12 amends the approaches and methodologies in accounting for income taxes during interim periods and makes changes to certain income tax classifications. The new standard allows exceptions to the use of the incremental approach for intra-period tax allocation, when there is a loss from continuing operations and income or a gain from other items, and to the general methodology for calculating income taxes in an interim period, when a year-to-date loss exceeds the anticipated loss for the year. The standard also requires franchise or similar taxes partially based on income to be reported as income tax and the effects of enacted changes in tax laws or rates to be included in the annual effective tax rate computation from the date of enactment. Lastly, in any future acquisition, the Company would be required to evaluate when the step-up in the tax basis of

goodwill is part of the business combination and when it should be considered a separate transaction. The Company adopted the standard as of January 1, 2021 and has evaluated the effects of this standard and determined that the adoption did not have a material impact on the Company’s consolidated financial statements.

3. Fair Value Measurements

The Company’s assets and liabilities measured at fair value on a recurring basis at ~~March 31,~~June 30, 2021 consisted of the following:

	Fair Value Measurement at March 31, 2021
	Total		Level 1		Level 2		Level 3

									Fair Value Measurement at June 30, 2021
									Total		Level 1		Level 2		Level 3
Assets:
Cash equivalents - money market funds	$	13,962,902	$	13,962,902	$	—	$	—	$	46,865,390	$	46,865,390	$	—	$	—
Short-term investments		76,574,768		—		76,574,768		—		43,723,840		—		43,723,840		—
Total		90,537,670		13,962,902		76,574,768		—		90,589,230		46,865,390		43,723,840		—
Liabilities:
Contingent consideration liability (see Note 8)		6,270,000		—		—		6,270,000		5,270,000		—		—		5,270,000
Total	$	6,270,000	$	—	$	—	$	6,270,000	$	5,270,000	$	—	$	—	$	5,270,000

The Company’s assets and liabilities measured at fair value on a recurring basis at December 31, 2020 consisted of the following:


	Fair Value Measurement at December 31, 2020
	Total		Level 1		Level 2		Level 3
Assets:
Cash equivalents - money market funds	$	90,389,473	$	90,389,473	$	—	$	—
Short-term investments		100,005,558		—		100,005,558		—
Total		190,395,031		90,389,473		100,005,558		—
Liabilities:
Contingent consideration liability (see Note 8)		5,390,000		—		—		5,390,000
Warrant liability		10,000		—		—		10,000
Total	$	5,400,000	$	—	$	—	$	5,400,000

Fair Value Measurement at December 31, 2020

Total

Level 1

Level 2

Level 3

Assets:

Cash equivalents - money market funds

$
90,389,473

$
90,389,473

$
—

$
—

Short-term investments

100,005,558

—

100,005,558

—

Total

190,395,031

90,389,473

100,005,558

—

Liabilities:

Contingent consideration liability (see Note 8)

5,390,000

—

—

5,390,000

Warrant liability

10,000

—

—

10,000

Total

$
5,400,000

$
—

$
—

$
5,400,000

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The warrant liability is included in Other long-term liabilities in the consolidated balance sheet at December 31, 2020. The warrant liability was valued using the Monte Carlo simulation valuation model with Level 3 inputs.

Short-term investments have been initially valued at the transaction price and subsequently valued, at the end of each reporting period, utilizing third party pricing services or other market observable data (Level 2). The pricing services utilize industry standard valuation models, including both income and market-based approaches and observable market inputs to determine value.

Short-term investments had quoted prices at ~~March 31,~~June 30, 2021 as shown below:


	June 30, 2021
			Unrealized Gain
	Amortized Cost		(Loss)		Market Value
United States treasury securities	$	8,005,129	$	431	$	8,005,560
Commercial paper and corporate debt securities		8,599,717		1,290		8,601,007
Asset backed securities		2,096,332		202		2,096,534
Certificate of deposit		25,020,739		—		25,020,739
Total	$	43,721,917	$	1,923	$	43,723,840

March 31, 2021

Amortized Cost

Unrealized Gain (Loss)

Market Value

United States treasury securities

$
16,029,965

$
2,995

$
16,032,960

Commercial paper and corporate debt securities

33,412,043

(1,935
)

33,410,108

Asset backed securities

2,111,239

(278
)

2,110,961

Certificate of deposit

25,020,739

—

25,020,739

Total

$
76,573,986

$
782

$
76,574,768

Short-term investments had quoted prices at December 31, 2020 as shown below:

	December 31, 2020
	Amortized Cost		Unrealized Gain (Loss)			Market Value

								December 31, 2020
										Unrealized Gain
								Amortized Cost		(Loss)		Market Value
United States treasury securities	$	20,052,757	$	1,843		$	20,054,600	$	20,052,757	$	1,843	$	20,054,600
Commercial paper and corporate debt securities		47,521,344		(5,440	)		47,515,904		47,521,344		(5,440)		47,515,904
Asset backed securities		7,414,619		(757	)		7,413,862		7,414,619		(757)		7,413,862
Certificate of deposit		25,021,192		—			25,021,192		25,021,192		—		25,021,192
Total	$	100,009,912	$	(4,354	)	$	100,005,558	$	100,009,912	$	(4,354)	$	100,005,558

The fair value of contingent payments classified as a liability is based on the regulatory milestones described in Note 8 and estimated using the Monte Carlo simulation valuation model with Level 3 inputs.

The assumptions used to estimate the fair value of contingent payments that are classified as a liability at ~~March 31,~~June 30, 2021 include the following significant unobservable inputs:


Unobservable input	Value or Range	Weighted Average
Expected volatility	94.6%	94.6%
Risk-free interest rate	0.07%	0.07%
Cost of capital	30%	30%
Discount for lack of marketability	11%‑15%	13%
Probability of payment	72%	72%
Projected year of payment	2022	2022

Unobservable input

Value or Range

Weighted Average

Expected volatility

117.4%

117.4%

Risk-free interest rate

0.09%

0.09%

Cost of capital

30%

30%

Discount for lack of marketability

16%-19%

18%

Probability of payment

63%

63%

Projected year of payment

2022

2022

If applicable, the Company will recognize transfers into and out of levels within the fair value hierarchy at the end of the reporting period in which the actual event or change in circumstance occurs. There were no0 transfers into and out of any of the levels of the fair value hierarchy as of ~~March 31,~~June 30, 2021 and December 31, 2020.

Separate disclosure is required for assets and liabilities measured at fair value on a recurring basis from those measured at fair value on a non-recurring basis. Assets recorded at fair value on a non-recurring basis, such as property and equipment and intangible assets are recognized at fair value when they are impaired. As of ~~March 31,~~June 30, 2021, the Company recorded a non-cash impairment charge to property and equipment, net on a non-recurring basis (see below). As of December 31, 2020, the Company had no0 significant assets or liabilities that were measured at fair value on a non-recurring basis.

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Property and Equipment, Net

During the three and six months ended June 30, 2021, the Company recorded a non-cash impairment charge of $8.1 million to property and equipment, net. The fair value of the impaired assets was $3.3 million at June 30, 2021. At June 30, 2021, the fair value of the assets related to construction-in-progress were primarily determined utilizing the cost approach, which determines the current replacement cost of the asset being appraised and then deducts for the loss in value caused by contractual restrictions on the asset, physical deterioration, functional obsolescence, and economic obsolescence the amount required to replace the asset as if new and adjusts to reflect usage. The fair value measurement is considered Level 3 measurements within the valuation hierarchy.

4. Property and Equipment, Net

Property and equipment, net consists of the following:

March 31, 2021

December 31, 2020

Furniture, fixtures and equipment

$
185,878

$
125,538

Laboratory equipment

1,041,752

959,585

Computers and telecommunications

250,516

220,316

Software

64,409

64,409

Leasehold improvements

1,415,608

1,285,883

Construction-in-progress

4,000,000

—

Property and equipment, at cost

6,958,163

2,655,731

Less: accumulated depreciation and amortization

(1,760,111
)

(1,598,811
)
Property and equipment, net

$
5,198,052

$
1,056,920


	June 30, 2021		December 31, 2020
Furniture, fixtures and equipment	$	190,117	$	125,538
Laboratory equipment		1,041,749		959,585
Computers and telecommunications		270,755		220,316
Software		94,409		64,409
Leasehold improvements		1,682,538		1,285,883
Construction-in-progress		3,300,000		—
Property and equipment, at cost		6,579,568		2,655,731
Less: accumulated depreciation and amortization		(1,828,558)		(1,598,811)
Property and equipment, net	$	4,751,010	$	1,056,920

As of ~~March 31,~~June 30, 2021, construction-in-progress primarily includes costs related to the procurement of long-lead equipment and build out of the suite associated with the ~~Company's~~Company’s manufacturing collaboration with Lonza Houston, Inc. (“Lonza”) ~~described~~for the manufacture of AdCOVID or other adenovirus-based vaccines. Under the agreement, the Company has committed approximately $23.0 million to Lonza to procure long-lead equipment and construct a dedicated manufacturing suite for clinical and commercial production of adenovirus-based vaccines. This work is expected to be completed by the end of 2021.

In June 2021, the Company announced the discontinuation of further development of AdCOVID following the Company’s review of findings from the Phase 1 clinical trial. Construction continues at Lonza, and the Company is currently assessing its strategic options with respect to the suite. The Company’s current expectation is that, more likely than not, the suite will be disposed of significantly before the end of its previously estimated useful life. As of June 30, 2021, the Company recorded $8.1 million of impairment loss on construction-in-progress in ~~Note 16.~~ the accompanying unaudited consolidated statements of operations and comprehensive loss, with $3.3 million remaining capitalized in the unaudited consolidated balance sheet, as it represents expected recoveries available to the Company under the construction contract.

Depreciation expense related to property and equipment was approximately ~~$67,658~~$68,450 and ~~$59,505,~~$60,664 for the three months ended ~~March 31,~~June 30, 2021 and 2020, respectively, and $136,108 and $120,169 for the six months ended June 30, 2021 and 2020, respectively.

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5. Intangible Assets

The Company’s intangible assets ~~consisted~~consists of the following:


	June 30, 2021
		Gross
	Estimated	Carrying		Accumulated		Net Book
	Useful Lives	Value		Amortization		Value
Internally developed patents	6–20 years	$	1,030,333	$	(493,188)	$	537,145
Acquired licenses	16–20 years		285,000		(285,000)		—
Total intangible assets subject to amortization			1,315,333		(778,188)		537,145
IPR&D assets	Indefinite		12,418,967		—		12,418,967
Total		$	13,734,300	$	(778,188)	$	12,956,112

	March 31, 2021
	Estimated Useful Lives	Gross Carrying Value		Accumulated Amortization			Net Book Value

									December 31, 2020
										Gross
									Estimated	Carrying		Accumulated		Net Book
									Useful Lives	Value		Amortization		Value
Internally developed patents	6-20 years	$	946,828	$	(486,548	)	$	460,280	6–10 years	$	884,787	$	(479,908)	$	404,879
Acquired licenses	16-20 years		285,000		(285,000	)		—	16–20 years		285,000		(285,000)		—
Total intangible assets subject to amortization			1,231,828		(771,548	)		460,280			1,169,787		(764,908)		404,879
IPR&D assets	Indefinite		12,418,967		—			12,418,967	Indefinite		12,418,967		—		12,418,967
Total		$	13,650,795	$	(771,548	)	$	12,879,247		$	13,588,754	$	(764,908)	$	12,823,846

December 31, 2020

Estimated
Useful Lives

Gross
Carrying
Value

Accumulated
Amortization

Net Book
Value

Internally developed patents

6-10 years

$
884,787

$
(479,908
)

$
404,879

Acquired licenses

16-20 years

285,000

(285,000
)

—

Total intangible assets subject to amortization

1,169,787

(764,908
)

404,879

IPR&D assets

Indefinite

12,418,967

—

12,418,967

Total

$
13,588,754

$
(764,908
)

$
12,823,846

Amortization expense of intangible assets was $6,640 and ~~$13,851~~$12,025 for the three months ended ~~March 31,~~June 30, 2021 and 2020, respectively, and $13,280 and $25,876 for the six months ended June 30, 2021 and 2020, respectively. As of ~~March 31,~~June 30, 2021, the weighted average amortization period remaining for intangible assets was ~~12.3~~12.2 years. Amortization expense was classified as research and development expenses in the accompanying unaudited consolidated statements of operations and comprehensive loss.

6. Operating Leases

The Company rents office and laboratory space in the United States. The Company also leases office equipment under a non-cancellable equipment lease through December 2022. Rent expense during the three and six months ended ~~March 31,~~June 30, 2021 under all of the Company’s operating leases was $123,734 and $253,872, respectively. Rent expense during the three and six months ended June 30, 2020 under all of the Company’s operating leases was ~~$130,138~~$86,295 and ~~$87,599,~~$173,894, respectively. Rent expense includes short-term leases and variable lease costs that are not included in the lease obligation.

Short-term leases are leases having a term of twelve months or less. The Company recognizes short-term leases on a straight-line basis and does not record a related lease asset or liability for such leases.

The office space leases provide for increases in future minimum annual rental payments as defined in the lease agreements. The office space lease also includes an option to renew the lease as of the end of the term. The Company has determined that the lease renewal option is not reasonably certain of being exercised.

The cash paid for operating lease liabilities for the three and six months ended ~~March 31,~~June 30, 2021 was $118,843 and $236,197, and for the three and six months ended June 30, 2020 was ~~$117,354~~$96,770 and ~~$95,714,~~$192,484, respectively.

Supplemental other information related to the operating leases balance sheet information ~~was~~is as follows:


	June 30, 2021			December 31, 2020
Operating lease obligations (see Note 7 and 9)	$	1,651,217		$	1,824,840
Operating lease right-of-use assets (included in "Other assets" in Balance Sheet)	$	827,273		$	903,825
Weighted-average remaining lease term (years)		3.8			4.3
Weighted-average discount rate		7.3	%		7.3	%

March 31, 2021

December 31, 2020

Operating lease obligations (see Note 7 and 9)

$
1,739,559

$
1,824,840

Operating lease right-of-use assets

$
866,336

$
903,825

Weighted-average remaining lease term (years)

4.1

4.3

Weighted-average discount rate

7.3
%

7.3
%

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7. Accrued Expenses

Accrued expenses and other current liabilities consist of the following:

	March 31, 2021		December 31, 2020

					June 30, 2021		December 31, 2020
Accrued professional services	$	612,212	$	1,350,194	$	489,836	$	1,350,194
Accrued payroll and employee benefits		1,182,658		2,351,599		1,661,708		2,351,599
Accrued interest		13,744		13,016		16,456		13,016
Accrued research and development		7,211,778		7,316,876		5,074,045		7,316,876
Lease obligation, current portion (see Note 6)		365,504		356,716		374,502		356,716
Deferred revenue		19,753		19,753		57,989		19,753
Total accrued expenses	$	9,405,649	$	11,408,154	$	7,674,536	$	11,408,154

8. Contingent Consideration

The Company entered into an Agreement and Plan of Merger and Reorganization, dated July 8, 2019, by and among the Company, Springfield Merger Sub, Inc., Springfield Merger Sub, LLC, Spitfire Pharma, Inc. and David Collier, as the Stockholder Representative (the “Spitfire Merger Agreement”) to acquire all of the equity interests of Spitfire Pharma, Inc. (“Spitfire”). Spitfire was a privately held, preclinical pharmaceutical company developing a novel dual GLP-1/glucagon receptor agonist for the treatment of non-alcoholic steatohepatitis.

The transaction closed on July 12, 2019. The Company issued 1,887,250 unregistered shares of its common stock (the “shares”) as upfront consideration to certain former securityholders of Spitfire (collectively, the “Spitfire Equityholders”), representing an amount equal to $5.0 million less working capital and transaction expense adjustment amounts as defined in the agreement.

The acquisition of Spitfire was accounted for as an asset acquisition instead of a business combination because substantially all of the fair value of the gross assets acquired was concentrated in a single identifiable asset or group of similar identifiable assets, and therefore, the asset was not considered a business. The Company expensed the acquired intellectual property as of the acquisition date as in-process research and development with no alternative future uses.

The Spitfire Merger Agreement also includes future contingent payments up to $88.0 million in cash and shares of the Company’s common stock as follows (each, a “Milestone Event”):

●

a one-time payment of $5.0 million (the “IND Milestone Consideration Amount”) within sixty days of the submission of an Investigational New Drug Application (“IND”) to the United States Food and Drug Administration (the “FDA”) or other applicable governmental authority in a foreign jurisdiction, which IND has not been rejected or placed on clinical hold by the FDA or such applicable foreign governmental authority within time specified in the Merger Agreement;

●

a one-time payment of $3.0 million (the “Phase 2 Milestone Consideration Amount” and together with the IND Milestone Consideration Amount, the “Regulatory Milestones”) within sixty days of the initiation of a Phase 2 clinical trial of a product candidate anywhere in the world; and

●

payments of up to $80.0 million upon the achievement of specified worldwide net sales (the “Sales Milestones”) of all products developed using the technology acquired in the License Agreement within ten years following the approval of a new drug application filed with the FDA.

The Regulatory Milestones will be payable in shares of the Company’s Common Stock, with the number of shares of the Company’s Common Stock to be issued in connection with each milestone amount, if any, are dependent on the share price at the time of achievement. The number of any shares issued in consideration for the IND Milestone Consideration Amount will be determined based on lower of (A) the average of the closing prices of our Common Stock

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as reported on the Nasdaq Global Market for the twenty (20) consecutive trading days prior to the IND Reference Date or (B) $2.95. The value of any shares issued in consideration for the Phase 2 Milestone Consideration Amount shall be determined based the lower of (A) on the average of the closing trading prices of our Common Stock as reported on the Nasdaq Global Market for the twenty (20) consecutive trading days immediately preceding the date of the occurrence of the Phase 2 Milestone Event or (B) $3.54.

The future contingent payments related to the Regulatory Milestones are stock-based payments accounted for under FASB Accounting Standards Codification Topic 480, Distinguishing Liabilities From Equity (“ASC 480”). Such stock-based payments are subject to a lock-up whereby 50% of the shares are released at 3 months and 50% are released at 6 months. The future contingent payments related to the Sales Milestones are predominately cash-based payments accounted for under FASB Accounting Standards Codification Topic 450, Contingencies. Accordingly, the Company will recognize the Sales Milestones when the contingency is resolved and the amount is paid or payable.

The Company estimates the future contingent consideration for the Regulatory Milestones based upon a Monte Carlo simulation valuation model that is risk adjusted based on the probability of achieving the milestones and a discount for lack of marketability. The Company remeasures the fair value of the contingent consideration at each reporting period. During the fourth quarter of 2020, the Company achieved the IND Milestone and paid the obligation in shares according to the calculation above. Below is a summary of the contingent consideration activity:

Three Months Ended March 31,

2021

2020

Beginning balance

$
5,390,000

$
2,750,000

Change in fair value

880,000

1,750,000

Ending balance

$
6,270,000

$
4,500,000


	Six Months Ended June 30,
	2021		2020
Beginning balance	$	5,390,000	$	2,750,000
Change in fair value		(120,000)		13,640,000
Ending balance	$	5,270,000	$	16,390,000

As of ~~March 31,~~June 30, 2021, the decrease in fair value was primarily attributable to a decrease in the closing share price of the Company’s common stock, partially offset by an increase in the probability of milestone achievement. As of June 30, 2020, the increase in fair value was primarily attributable to an increase in the closing share price of the Company’s common stock and in the probability of milestone achievement. ~~As of March 31, 2020, the increase in fair value was primarily due to an increase in the probability of milestone achievement.~~ Any changes in fair value have been recorded within research and development expense during the respective periods presented.

9. Other Long-Term Liabilities

The Company’s other long-term liabilities are summarized as follows:

	March 31, 2021		December 31, 2020

					June 30, 2021		December 31, 2020
Lease obligation, long-term portion (see Note 6)	$	1,374,055	$	1,468,124	$	1,276,715	$	1,468,124
Conditional economic incentive grants		250,000		250,000		250,000		250,000
Other		95,383		110,319		90,435		110,319
Total other long-term liabilities	$	1,719,438	$	1,828,443	$	1,617,150	$	1,828,443

10. Common Stock

Public Offering

On July 16, 2020, the Company offered and sold (i) 3,369,564 shares of common stock, at a price to the public of $23.00 per share, and (ii) pre-funded warrants of the Company to purchase 1,630,436 shares of common stock at an exercise price equal to $0.0001 per share (the “Pre-Funded Warrants”), at a price to the public of $22.9999 per share of common stock underlying the Pre-Funded Warrants (equal to the public offering price per share of Common Stock, minus the exercise price of each Pre-Funded Warrant). The Pre-Funded Warrants are exercisable at any time, provided that each Pre-Funded Warrant holder will be prohibited from exercising such Pre-Funded Warrants into shares of the Company’s common stock if, as a result of such exercise, the holder, together with its affiliates, would own more than 4.99% of the total number of shares of the Company’s common stock then issued and outstanding, which percentage may change at the

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holders’ election to any other number less than or equal to 19.99% upon 61 days’ notice to the Company. The gross proceeds of this offering were approximately $132.2 million, which includes the exercise in full of the underwriters’ option to purchase an additional 750,000 shares of common stock, before deducting underwriting discounts and commissions and offering expenses during the third quarter of 2020. The net proceeds of this offering were approximately $124.0 million, after deducting underwriting discounts and commissions and offering expenses payable by the Company.

The Company has assessed the Pre-Funded Warrants for appropriate equity or liability classification and determined that the Pre-Funded Warrants are freestanding instruments that do not meet the definition of a liability pursuant to ASC 480 and do not meet the definition of a derivative pursuant to FASB Accounting Standards Codification Topic 815, Derivatives and Hedging (“ASC 815”). The Pre-Funded Warrants are indexed to the Company’s common stock and meet all other conditions for equity classification under ASC 480 and ASC 815. Accordingly, the Pre-Funded Warrants are classified as equity and are accounted for as a component of additional paid-in capital at the time of issuance. As of ~~March 31,~~June 30, 2021, no0 Pre-Funded Warrants were exercised.

At-the-Market Offerings

On February 25, 2021, the Company entered into an Equity Distribution Agreement (the “2021 Agreement”) with Piper Sandler & Co., Evercore Group L.L.C., and B. Riley Securities, Inc., serving as sales agents (the “Sales Agents”) with respect to an at-the-market ~~offering~~offerings program under which the Company may offer and sell, from time to time at its sole discretion, shares of its common stock, par value $0.0001 per share (the “Common Stock”), having an aggregate offering price of up to $125.0 million (the “Shares”) through the Sale Agents (the “2021 Offering”). Any Shares offered and sold in the 2021 Offering will be issued pursuant to the Company’s Registration Statement on Form S-3 filed with the Securities and Exchange Commission (the “SEC”) on December 31, 2020, which was declared effective on January 11, 2021, the prospectus supplement relating to the 2021 Offering filed with the SEC on February 25, 2021 and any applicable additional prospectus supplements related to the 2021 Offering that form a part of the Registration Statement.

As of ~~March 31,~~June 30, 2021, the Company has sold ~~2,110,800~~3,516,510 shares of Common Stock under the 2021 Agreement resulting in approximately ~~$34.2~~$52.4 million in net proceeds, with ~~$89.7~~$70.9 million remaining available to be sold under the 2021 Agreement. As of ~~March 31,~~June 30, 2021, the Company recorded approximately $0.1 million of offering costs which offset the proceeds received from the shares sold through ~~March 31,~~June 30, 2021 and recognized approximately $0.1 million of deferred offering costs which will offset future proceeds received under the 2021 Agreement.

On March 27, 2020, the Company entered into an Equity Distribution Agreement (the “2020 Agreement”) with JMP Securities LLC, serving as placement agent (the “Placement Agent”) with respect to an at-the-market ~~offering~~offerings program under which the Company may offer and sell, from time to time at its sole discretion, shares of its common stock, par value $0.0001 per share (the “Common Stock”), having an aggregate offering price of up to $50.0 million (the “Shares”) through the Placement Agent (the “2020 Offering”). Any Shares offered and sold in the 2020 Offering were issued pursuant to the Company’s Registration Statement on Form S-3 filed with the SEC on April 4, 2019, which was declared effective on April 12, 2019, the prospectus supplement relating to the 2020 Offering filed with the SEC on March 27, 2020 and any applicable additional prospectus supplements related to the 2020 Offering that form a part of the Registration Statement. The aggregate market value of Shares eligible for sale in the 2020 Offering and under the 2020 Agreement were subject to the limitations of General Instruction I.B.6 of Form S-3, to the extent required under such instruction. The Company offered Shares having an aggregate offering price of $18.9 million pursuant to the prospectus supplement filed with the SEC on March 27, 2020. On June 1, 2020, the Company filed an amendment to the 2020 Agreement which amended the prospectus supplement dated March 27, 2020 to increase the aggregate offering price to $50.0 million.No As of June 30, 2020, the Company sold 2,965,144 shares of Common Stock under the amended 2020 Agreement resulting in $22.8 million in net proceeds. As of June 30, 2021, the 2020 Agreement was fully utilized and 0 Shares were sold under the 2020 Agreement during the three and six months ended ~~March 31, 2020. As of March 31, 2021, the 2020 Agreement was fully utilized and no Shares were sold under the 2020 Agreement during the three months ended March 31,~~June 30, 2021.

Exchange Agreement

On February 25, 2021, the Company entered into an exchange agreement (the “Exchange Agreement”) with an Investor and its affiliates (the “Exchanging Stockholders”), pursuant to which the Company exchanged an aggregate of 1,000,000 shares of the Company’s common stock, par value $0.0001 per share, owned by the Exchanging Stockholders

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for pre-funded warrants (the “Exchange Warrants”) to purchase an aggregate of 1,000,000 shares of common stock (subject to adjustment in the event of any stock dividends and splits, reverse stock split, recapitalization, reorganization or similar transaction, as described in the Exchange Warrants), with an exercise price of $0.0001 per share. The Exchange Warrants do not expire and are exercisable at any time except that the Exchange Warrants cannot be exercised by the Exchanging Stockholders if, after giving effect thereto, the Exchanging Stockholders would beneficially own more than 9.99% of the Company’s common stock, subject to certain exceptions. In accordance with FASB Accounting Standards Codification Topic 505, Equity, the

Company recorded the retirement of the common stock exchanged as a reduction of common shares outstanding and a corresponding debit to additional paid-in-capital and accumulated deficit at the fair value of the Exchange Warrants on the issuance date. The Exchange Warrants ~~are~~were classified as equity in accordance with ASC 480 and the fair value of the Exchange Warrants was recorded as a credit to additional paid-in-capital and is not subject to remeasurement. The Company determined that the fair value of the Exchange Warrants is substantially similar to the fair value of the retired shares on the issuance date due to the negligible exercise price for the Exchange Warrants. As of ~~March 31,~~June 30, 2021, ~~none~~NaN of the Exchange Warrants have been exercised.

11. Warrants

A summary of warrant activity during the ~~three~~six months ended ~~March 31,~~June 30, 2021 is as follows:


Warrants outstanding, December 31, 2020	1,777,611
Exchanges (see Note 10)	1,000,000
Exercises	~~(1,420~~	)	(1,420)
Warrants outstanding, ~~March 31,~~June 30, 2021	2,776,191

As of ~~March 31,~~June 30, 2021, all of the common stock warrants that were previously classified as a liability were exercised in full.

12. Stock-Based Compensation

Stock Options

The Company’s stock option awards generally vest over four years and typically have a contractual life of ten years. At ~~March 31,~~June 30, 2021, there was ~~$10.1~~$10.9 million of unrecognized compensation cost related to stock options, which is expected to be recognized over a weighted-average period of ~~2.9~~3.0 years. During the ~~three~~six months ended ~~March 31,~~June 30, 2021, the Company granted ~~669,000~~907,000 stock options with a weighted average exercise price of ~~$16.73~~$15.00 and per share weighted average grant date fair value of ~~$13.76.~~$12.35.

Information related to stock options outstanding at ~~March 31,~~June 30, 2021 is as follows:

	Number of Stock Options		Weighted- average Exercise Price		Weighted- average Remaining Contractual Term (Years)		Aggregate Intrinsic Value

												Weighted-Average
										Weighted-		Remaining
									Number of	Average		Contractual Term	Aggregate Intrinsic
									Stock Options	Exercise Price		(Years)	Value
Outstanding		2,293,367	$	8.11		6.0	$	16,651,695	2,492,949	$	8.31	5.96	$	17,162,458
Exercisable		773,781	$	5.35		5.8	$	7,855,753	863,736	$	5.36	5.79	$	8,464,765
Unvested		1,519,586	$	9.51		6.0	$	8,795,942	1,629,213	$	9.87	6.05	$	8,697,693

Restricted Stock

At ~~March 31,~~June 30, 2021, the Company had unvested restricted stock of ~~134,545~~114,363 shares with total unrecognized compensation expense of ~~$0.5~~$0.4 million, which the Company expects to recognize over a weighted average period of approximately ~~1.7~~1.4 years. During the ~~three~~six months ended ~~March 31,~~June 30, 2021, the Company released ~~20,181~~40,363 shares of common stock from restriction as a result of the vesting of restricted stock.

~~In February~~14

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During the six months ended June 30, 2021, the Company granted ~~181,279~~196,279 shares of restricted stock units which vest over four years. At ~~March 31,~~June 30, 2021, the Company had unvested restricted stock units of ~~196,279~~211,279 shares with total unrecognized compensation expense of ~~$2.8~~$2.7 million, which the Company expects to recognize over a weighted average period of approximately ~~3.8~~3.6 years.

2019 Employee Stock Purchase Plan

Under the Employee Stock Purchase Plan, employees purchased 8,733 shares for $0.1 million during the ~~three~~six months ended ~~March 31,~~June 30, 2021. During the three and six months ended ~~March 31,~~June 30, 2021, the Company recognized compensation expense of $0.1 ~~million.~~million and $0.2 million, respectively.

Stock-based Compensation Expense

Stock-based compensation expense is classified in the unaudited consolidated statements of operations and comprehensive loss for the three and six months ended ~~March 31,~~June 30, 2021 and 2020 as follows:


	For the Three Months Ended				For the Six Months Ended
	June 30,				June 30,
	2021		2020		2021		2020
Research and development	$	440,340	$	77,939	$	761,678	$	106,939
General and administrative		1,044,489		252,571		1,941,502		438,492
Total	$	1,484,829	$	330,510	$	2,703,180	$	545,431

For the Three Months Ended
March 31,

2021

2020

Research and development

$
321,338

$
29,000

General and administrative

897,013

185,921

Total

$
1,218,351

$
214,921

13. U.S. Government Contracts and Grants

In June 2020, the Company was awarded $4.7 million from the U.S. Army Medical Research & Development Command (“USAMRDC”) to fund our Phase 1/2 clinical trial of T-COVID. The competitive award was granted by USAMRDC in collaboration with the Medical Technology Enterprise Consortium (“MTEC”), a 501(c)(3) biomedical technology consortium working in partnership with the Department of Defense (“DoD”). Under the contract, MTEC will pay the Company a firm fixed fee based upon the achievement of certain milestones for conduct and completion of a Phase 1/2 study and research and development work on the replication-deficient adenovirus 5 (“RD-Ad5”) vector vaccine platform. For the ~~three~~six months ended ~~March 31,~~June 30, 2021, the Company has recognized approximately $0.5 million of grant revenue under the contract.

In July 2016, the Company signed a five-year contract with BARDA. The contract, as amended, has a total value of up to $133.7 million and is used to fund clinical development of NasoShield. Under the contract, BARDA pays the Company a fixed fee and reimburses certain costs for the research and development of an Ad5-vectored, protective antigen-based intranasal anthrax vaccine through cGMP manufacture and conduct of a Phase 1 clinical trial dose ranging assessment of safety and immunogenicity. The contract consists of an initial base performance period providing approximately $27.8 million in funding for the period July 2016 through ~~June~~September 2021. BARDA has seven options to extend the contract to fund certain continued development and manufacturing activities for the anthrax vaccine, including Phase 2 clinical studies. Each option, if exercised by BARDA, would provide additional funding ranging from approximately $1.1 million to $34.4 million for a three-year period beginning in 2021. For the three and six months ended ~~March 31,~~June 30, 2021, ~~and 2020,~~ the Company has recognized approximately ~~$0.2~~$0.1 million and ~~$1.6~~$0.3 million, respectively, of grant revenue under the current BARDA contract. For the three and six months ended June 30, 2020, the Company recognized approximately $0.5 million and $2.1 million, respectively, of grant revenue under the current BARDA contract.

14. Income Taxes

Due to a full valuation allowance, the Company did not record an income tax benefit for the ~~three~~six months ended ~~March 31,~~June 30, 2021.

With respect to the prior year, on March 27, 2020, President Donald Trump signed into law the Coronavirus Aid, Relief, and Economic Security Act (the “CARES Act”). The CARES Act provided both stimulus measures and a number

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of tax provisions, including: temporary changes regarding the utilization and carry back of net operating losses, temporary changes to the prior and future limitations on interest deductions, technical corrections from prior tax legislation for tax depreciation of qualified improvement property, and certain refundable employee retention credits. As of ~~March 31,~~June 30, 2020, the Company recognized a total tax benefit of ~~$3.2~~$4.8 million related to the carry back of losses back to obtain a refund of its 2016 tax liability.

15. Net Loss Per Share

Because the Company has reported a net loss attributable to common stockholders for all periods presented, basic and diluted net loss per share attributable to common stockholders are the same for all periods presented.

Basic net loss per share attributable to common stockholders is computed by dividing the net loss attributable to common stockholders by the weighted average numbers of shares of common stock outstanding for the period. Basic shares outstanding includes the weighted average effect of the Company’s outstanding pre-funded warrants, the exercise of which requires little or no consideration for the delivery of shares of common stock.

Diluted net loss per share is calculated by adjusting weighted average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period. As such, all unvested restricted stock, common stock warrants, and stock options have been excluded from the computation of diluted weighted average shares outstanding because such securities would have an anti-dilutive impact for all periods presented.

Potential common shares issuable upon conversion, vesting or exercise of unvested restricted stock, common stock warrants, and stock options that are excluded from the computation of diluted weighted-average shares outstanding, as they are anti-dilutive, are as follows:


	For the Three and Six	For the Three and Six
	Months Ended	Months Ended
	June 30, 2021	June 30, 2020
Common stock warrants	145,755	2,150,285
Common stock options	2,506,846	1,527,978
Restricted stock	325,642	304,686

For the Three Months Ended
March 31,

2021

2020

Common stock warrants

145,755

10,370,206

Common stock options

2,307,264

1,423,612

Restricted stock

330,824

215,413

16. Commitments and Contingencies

Spitfire Acquisition

As disclosed in Note 8, the Company is obligated to make payments of up to $80.0 million upon the achievement of specified worldwide net sales of all products developed using the technology acquired from Spitfire Pharma Inc. within ten years following the approval of a new drug application filed with the FDA.

~~PER.C6 License Agreement Expansion~~

On April 2, 2020, the Company entered into Amendment No. 3 to the Second Restated License Agreement (the “Amendment”), by and between the Company and Janssen Vaccines & Prevention B.V. (formerly known as Crucell Holland B.V.) (as amended by Amendment No. 1 to Second Restated License Agreement and Amendment No. 2 to Second Restated License Agreement, together with the Amendment, the “License Agreement”). Pursuant to the Amendment, the field of licenses granted to the Company for the use of the PER.C6 cell line under the License Agreement is expanded to cover COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), in addition to the existing licenses related to Bacillus anthracis and influenza virus. All capitalized terms not defined herein shall have the meanings assigned to them in the Amendment or the License Agreement, as applicable.

Pursuant to the Amendment, the Company agreed to pay certain additional development-based milestone payments through approval of licensed products by the FDA for the treatment or prevention of COVID-19, up to an aggregate amount of $1.2 million. The Company also agreed to pay royalty payments as a percentage of net sales of products to a royalty stacking reduction and minimum annual royalty payments, until the expiration of the term of the License Agreement, as amended. As of March 31, 2021, no payments were made under the License Agreement.

Lonza Manufacturing Agreement

In March 2021, the Company expanded its manufacturing collaboration with Lonza in connection with the Manufacturing Agreement entered into in November 2020 for the manufacture of AdCOVID. Under the expanded agreement, the Company has committed approximately $23.0 million to Lonza to procure long-lead equipment and construct a dedicated manufacturing suite for clinical and commercial production of AdCOVID. ~~This work is expected to be completed during the fourth quarter of 2021.~~ As of ~~March 31,~~June 30, 2021, the Company ~~capitalized approximately $4.0 million~~decided to ~~construction-in-progress related to the equipment purchase and build out of the suite under the expanded agreement.~~

~~Summit Biosciences Development and Manufacturing Agreement~~

~~In March 2021, the Company entered into a~~discontinue further development ~~and manufacturing agreement with Summit Biosciences, Inc. (“Summit”) to manufacture a metered nasal spray presentation~~ of AdCOVID. ~~Under the agreement, the Company has committed approximately $6.7 million~~Refer to ~~Summit~~Note 4 for the clinical manufacturing of AdCOVID multidose nasal spray. This work is expected to be completed by the end of 2021. As of March 31, 2021, the Company recorded approximately $1.4 million to prepaid expenses under the agreement.further details.

Litigation

In December 2019, a complaint was filed by Dr. De-Chu Christopher Tang (“Plaintiff”) against the Company, which the Company removed to the United States District Court for the Eastern District of Texas. The Plaintiff amended the complaint in February 2020 to include Vipin K. Garg and David J. Drutz as defendants, in addition to the Company (Dr. Garg, Dr. Drutz, and the Company are collectively referred to as “Defendants”). On November 6, 2020, Defendants filed a motion for summary judgment on the basis of lack of personal jurisdiction, insufficient service of process, and failure to state a claim. The court ruled on that motion on March 25, 2021, which dismissed the case on the basis of lack of personal jurisdiction. As the outcome of this legal proceeding is certain at this time, the Company has not accrued any liability associated with this action.

The Company is a party in various ~~other contractual~~contracts and subject to disputes, litigation, and potential claims arising in the ordinary course of business, none of which are currently reasonably possible or probable of material loss.

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Item 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion and analysis of our financial condition and results of operations should be read together with our consolidated financial statements and related notes appearing elsewhere in this ~~quarterly report~~Quarterly Report on Form 10-Q and our consolidated financial statements and related notes for the year ended December 31, 2020 included in our ~~annual report~~Annual Report on Form 10-K, which was filed with the Securities and Exchange Commission on February 25, 2021.

This ~~quarterly report~~Quarterly Report on Form 10-Q contains forward-looking statements that involve substantial risks and uncertainties. The words “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “may,” “will,” “should,” “could,” “target,” “strategy,” “intend,” “project,” “guidance,” “likely,” “usually,” “potential,” or the negative of these words or variations of such words, similar expressions, or comparable terminology are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. There are a number of important risks and uncertainties that could cause our actual results to differ materially from those indicated by forward-looking statements. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. We have included important factors in the cautionary statements included in this ~~quarterly report~~Quarterly Report on Form 10-Q, particularly in the section entitled “Risk Factors” in Part II, Item 1A, that could cause actual results or events to differ materially from the forward-looking statements that we make. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments that we may make.

We have based the forward-looking statements included in this ~~quarterly report~~Quarterly Report on Form 10-Q on information available to us on the date of this quarterly report, and we assume no obligation to update any such forward-looking statements, other than as required by law. Although we undertake no obligation to revise or update any forward-looking statements, whether as a result of new information, future events or otherwise, you are advised to consult any additional disclosures that we may make directly to you or through reports that we, in the future, may file with the SEC, including ~~annual reports~~Annual Reports on Form 10-K, ~~quarterly reports~~Quarterly Reports on Form 10-Q and ~~current reports~~Current Reports on Form 8-K.

Overview

Altimmune, Inc. is a clinical stage biopharmaceutical company focused on developing ~~intranasal vaccines, immune modulating therapies and~~ treatments for obesity and liver ~~disease.~~diseases. Our ~~diverse~~ pipeline includes next generation peptide therapeutics for obesity, NASH (ALT-801) and chronic hepatitis B (HepTcell); proprietary intranasal ~~vaccines for COVID-19 (AdCOVID), anthrax (NasoShield)~~vaccines; and ~~influenza (NasoVAX);~~ an intranasal immune modulating therapeutic for the coronavirus disease (“COVID-19”) (T-COVID). In June 2021, we announced the discontinuation of further development of our COVID-19 ~~(T-COVID);~~vaccine candidate, AdCOVID following our review of findings from the Phase 1 clinical trial, and ~~next generation peptide therapeutics~~in view of the highly competitive COVID-19 landscape. In the study, AdCOVID was generally well tolerated, but the immunogenicity data demonstrated lower than expected immune responses for ~~non-alcoholic steatohepatitis (“NASH”) (ALT-801) and chronic hepatitis B (HepTcell).~~each of the immune parameters tested.

Impact of COVID-19

We are closely monitoring how the spread of ~~the coronavirus disease (“COVID-19”)~~COVID-19 is affecting our employees, business, preclinical studies and clinical trials. ~~In response~~We recently reopened our executive office to allow certain employees to return to the ~~COVID-19 pandemic, we have closed our executive offices~~office based on a phased approach that is intended to comply with ~~certain employees continuing their~~federal and state guidelines, with a focus on employee safety and optimal work ~~outside of our offices and travel for all employees has been restricted. Essential laboratory staff continue to work onsite with enhanced safety measures.~~environment. We are continuing our regular interactions with the FDA and other regulatory agencies and, based on current information, we do not anticipate COVID-19 to materially affect our regulatory timelines for ~~NasoShield, T-COVID, AdCOVID, ALT-801 and HepTcell.~~our ongoing clinical trials.

Although operations have not been materially affected by the COVID-19 pandemic as of and for the three and six months ended ~~March 31,~~June 30, 2021, at this time, however, there is significant uncertainty relating to the trajectory of the pandemic and the impact of related responses, and disruptions caused by the COVID-19 pandemic may result in difficulties or delays in initiating, enrolling, conducting or completing our planned and ongoing trials and the incurrence of unforeseen costs as a result of disruptions in clinical supply or preclinical study or clinical trial delays. The impact of COVID-19 on our future results will largely depend on future developments, which are highly uncertain and cannot be predicted with confidence, such as the ultimate geographic spread of the disease, the duration of the pandemic, travel restrictions and

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social distancing in the United States and other countries, business closures or business disruptions, the ultimate impact on financial markets and the global economy, and the effectiveness of actions taken in the United States and other countries to contain and treat the disease. In addition, a recurrence of COVID-19 cases could cause other widespread or more severe impacts depending on where infection rates are highest. We continue to monitor developments as we deal with the disruptions and uncertainties relating to the COVID-19 pandemic. See “Risk Factors— Our business, results of operations and financial condition may be adversely affected by the widespread outbreak of an illness or any other communicable disease, or any other public health crisis, including the ongoing coronavirus disease (COVID-19) pandemic.”Factors” in Part II, Item 1A of this Quarterly Report on Form ~~10-Q.~~10-Q and “Item 1A. Risk Factors” of our Annual Report on Form 10-K for the year ended December 31, 2020.

U.S. Government Contracts and Grants

completion of a Phase 1/2 study and research and development work on the replication-deficient adenovirus 5 (“RD-Ad5”) vector vaccine platform. For the ~~three~~six months ended ~~March 31,~~June 30, 2021, we have recognized approximately $0.5 million of grant revenue under the contract.

In July 2016, we signed a five-year contract with Biomedical Advanced Research and Development Authority (“BARDA”). The contract, as amended, has a total value of up to $133.7 million and is used to fund clinical development of NasoShield. Under the contract, BARDA pays us a fixed fee and reimburses certain costs for the research and development of an Ad5-vectored, protective antigen-based intranasal anthrax vaccine through cGMP manufacture and conduct of a Phase 1 clinical trial dose ranging assessment of safety and immunogenicity. The contract consists of an initial base performance period providing approximately $27.8 million in funding for the period July 2016 through ~~December 2020.~~September 2021. BARDA has seven options to extend the contract to fund certain continued development and manufacturing activities for the anthrax vaccine, including Phase 2 clinical trials. Each option, if exercised by BARDA, would provide additional funding ranging from approximately $1.1 million to $34.4 million for a three-year period beginning January 2021. For the three and six months ended ~~March 31,~~June 30, 2021, ~~and 2020,~~ we have recognized approximately ~~$0.2~~$0.1 million and ~~$1.6~~$0.3 million, respectively, of grant revenue under the current BARDA contract. For the three and six months ended June 30, 2020, we recognized approximately $0.5 million and $2.1 million, respectively, of grant revenue under the current BARDA contract.

Critical Accounting Policies and Significant Judgment and Estimates

Management’s Discussion and Analysis of Financial Condition and Results of Operations is based upon our unaudited consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the U.S. and the rules and regulations of the SEC for interim financial reporting. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues, expenses, and the disclosure of contingent liabilities in our consolidated financial statements. We base our estimates and judgments on historical experience, knowledge of current conditions, and expectations of what could occur in the future given available information.

There have been no changes in our critical accounting policies and significant judgment and estimates as disclosed in our ~~annual report~~Annual Report on Form 10-K for the year ended December 31, 2020 except for recently adopted accounting standards (See Note 2 to the consolidated financial statements appearing in Item 1 of this report). For more information regarding our critical accounting policies, we encourage you to read the discussion contained in Item 7 under the heading “Critical Accounting Policies and Significant Judgments and Estimates” and Note 2 “Summary of Significant Accounting Policies” included in the notes to the consolidated financial statements contained in our ~~annual report~~Annual Report on Form 10-K for the year ended December 31, 2020.

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Results of Operations

Comparison of the three months ended ~~March 31,~~June 30, 2021 and 2020:


	For the Three Months Ended
	June 30,
	2021		2020		Increase (Decrease)
Revenue	$	137,623	$	721,636	$	(584,013)	(81)	%
Operating expenses:
Research and development		13,272,412		16,594,250		(3,321,838)	(20)	%
General and administrative		3,658,653		2,545,356		1,113,297	44	%
Impairment loss on construction-in-progress		8,070,000		—		8,070,000	100	%
Total operating expenses		25,001,065		19,139,606		5,861,459	124	%
Loss from operations		(24,863,442)		(18,417,970)		(6,445,472)	(35)	%
Other income (expense):
Interest expense		(22,226)		(3,308)		(18,918)	(572)	%
Interest income		32,863		81,458		(48,595)	(60)	%
Other income (expense), net		26,098		(5,878)		31,976	544	%
Total other income, net		36,735		72,272		(35,537)	(49)	%
Net loss before income tax benefit		(24,826,707)		(18,345,698)		(6,481,009)	(35)	%
Income tax benefit		—		1,578,782		(1,578,782)	(100)	%
Net loss	$	(24,826,707)	$	(16,766,916)	$	(8,059,791)	(48)	%

Comparison of the six months ended June 30, 2021 and 2020:

	For the Three Months Ended March 31,
	2021			2020			Increase (Decrease)

													For the Six Months Ended
													June 30,
													2021		2020		Increase (Decrease)
Revenue	$	837,516		$	2,212,694		$	(1,375,178	)	(62	)	%	$	975,139	$	2,934,330	$	(1,959,191)	(67)	%
Operating expenses:
Research and development		11,877,900			7,187,531			4,690,369		65				25,150,312		23,781,781		1,368,531	6	%
General and administrative		3,821,420			2,331,917			1,489,503		64				7,480,073		4,877,273		2,602,800	53	%
Impairment loss on construction-in-progress														8,070,000		—		8,070,000	100	%
Total operating expenses		15,699,320			9,519,448			6,179,872		65				40,700,385		28,659,054		12,041,331	42	%
Loss from operations		(14,861,804	)		(7,306,754	)		(7,555,050	)	(103	)			(39,725,246)		(25,724,724)		(14,000,522)	(54)	%
Other income (expense):
Interest expense		(11,671	)		(1,885	)		(9,786	)	(519	)			(33,897)		(5,193)		(28,704)	(553)	%
Interest income		42,499			151,569			(109,070	)	(72	)			75,362		233,027		(157,665)	(68)	%
Other (expense) income, net		(33,132	)		25,542			(58,674	)	230				(7,034)		19,664		(26,698)	(136)	%
Total other (expense) income, net		(2,304	)		175,226			(177,530	)	(101	)
Total other income, net														34,431		247,498		(213,067)	(86)	%
Net loss before income tax benefit		(14,864,108	)		(7,131,528	)		(7,732,580	)	(108	)			(39,690,815)		(25,477,226)		(14,213,589)	(56)	%
Income tax benefit		—			3,245,879			(3,245,879	)	(100	)			—		4,824,661		(4,824,661)	(100)	%
Net loss	$	(14,864,108	)	$	(3,885,649	)	$	(10,978,459	)	(283	)	%	$	(39,690,815)	$	(20,652,565)	$	(19,038,250)	(92)	%

Revenue

Revenue consists primarily of research grants in the United States from MTEC for our T-COVID product candidate and BARDA for our NasoShield vaccine product candidate. These grants consist of firm fixed fee contracts based on milestones and cost reimbursement contracts, with a fixed fee based on either costs incurred or milestones met.

Revenue decreased by ~~$1.4~~$0.6 million, or ~~62%~~81%, for the three months ended ~~March 31,~~June 30, 2021, as compared to the same period in 2020. The decrease was primarily the result of a decrease in BARDA revenue due to timing of clinical trials and development activities on the NasoShield program.

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Revenue decreased by $2.0 million, or 67%, for the six months ended June 30, 2021, as compared to the same period in 2020. The decrease was primarily the result of:

~~a decrease of $2.0 million in BARDA revenue due to timing of clinical trials and development activities on the NasoShield program; and~~

~~an increase of $0.5 million in MTEC revenue attributable to a clinical trial and development work on the T-COVID program.~~

●

a decrease of $2.4 million in BARDA revenue due to timing of clinical trials, development activities and settlement of indirect rates on the NasoShield program; and

●

an increase of $0.5 million in MTEC revenue attributable to a clinical trial and development work on the T-COVID program.

Research and development expenses

Research and development operating expense ~~increased~~decreased by ~~$4.7~~$3.3 million, or ~~65%~~20%, for the three months ended ~~March 31,~~June 30, 2021, as compared to the same period in 2020. The decrease was primarily the result of:

●

a decrease of $13.0 million due primarily to a decrease in the fair value of contingent consideration liability with respect to the acquisition of ALT-801 and development activities for ALT-801;

●

an increase of $7.7 million due primarily to development activities for the COVID-19 program, AdCOVID (discontinued at the end of June 2021); and

●

an increase of $2.0 million in other pre-clinical and clinical projects and non-project specific research and development costs.

Research and development operating expense increased by $1.4 million, or 6%, for the six months ended June 30, 2021, as compared to the same period in 2020. The increase was primarily the result of:

●

an increase of $13.1 million due to development activities for the COVID-19 programs, which include AdCOVID (discontinued at the end of June 2021) and T-COVID;

●

an increase of $2.8 million in other pre-clinical and clinical projects and non-project specific research and development costs; and

●

a decrease of $14.5 million due primarily to a decrease in the fair value of contingent consideration liability with respect to the acquisition of ALT-801 and development activities for ALT-801.

~~an increase of $5.4 million due to development activities for the COVID-19 programs, which include AdCOVID and T-COVID; and~~

~~a decrease of $1.5 million due primarily to a decrease in the fair value of contingent consideration liability with respect to the acquisition of ALT-801 and development activities for ALT-801.~~

General and administrative expenses

General and administrative expense increased by ~~$1.5~~$1.1 million, or ~~64%~~44%, for the three months ended ~~March 31,~~June 30, 2021, and by $2.6 million, or 53%, for the six months ended June 30, 2021, as compared to the same period in 2020 due primarily to an increase in stock compensation expense and other labor related costs.

Impairment loss on construction-in-process

Impairment loss on construction-in-process reported during the three and six months ended June 30, 2021 represented a non-cash impairment charge recorded for assets that were previously capitalized in connection with the discontinuation of AdCOVID.

Total other ~~(expense)~~ income, net

Total other ~~(expense)~~ income, net decreased by less than $0.1 million and $0.2 million during the three and six months ended ~~March 31,~~June 30, 2021, respectively, as compared to the same period in 2020. The ~~decrease is~~net decreases are primarily due to changes in interest income.

Income tax benefit

Income tax benefit decreased by ~~$3.2~~$1.6 million and $4.8 million during the three and six months ended ~~March 31,~~June 30, 2021, respectively, as compared to the same period in 2020. In both 2020 and 2021, we had a valuation allowance against

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all of our deferred tax assets, but in 2020 a benefit was recognized related to a net operating loss carryback refund claim pursuant to the Coronavirus Aid, Relief, and Economic Security Act.

Liquidity and Capital Resources

Overview

Our primary sources of cash during the ~~three~~six months ended ~~March 31,~~June 30, 2021 were from sales of equity, maturities of short-term investments and cash receipts of ~~revenue from our BARDA and MTEC contracts.~~income tax refunds. Our cash, cash equivalents, restricted cash and short-term investments were ~~$226.5~~$217.9 million at ~~March 31,~~June 30, 2021. We believe, based on the operating cash requirements and capital expenditures expected for 2021 and 2022, our cash on hand and short-term investments at ~~March 31,~~June 30, 2021, together with expected ~~revenue~~collections from our government sponsored contracts and tax refunds, are sufficient to fund operations for at least a twelve-month period from the issuance date of our ~~March 31,~~June 30, 2021 consolidated financial statements.

We have not generated any revenues from the sale of any products to date, and there is no assurance of any future revenues from product sales. Our sources of revenue have consisted of grant revenues under our arrangements with BARDA for the development of NasoShield, MTEC for a clinical trial and development work on T-COVID, and to a lesser degree from other licensing arrangements. We have incurred significant losses since we commenced operations. As of ~~March 31,~~June 30, 2021, we had accumulated losses of ~~$210.9~~$235.8 million since our inception. In addition, we have not generated positive cash flows from operations. We have had to rely on a variety of financing sources, including the issuance of debt and equity securities. As capital resources are consumed to fund our research and development activities, we may not have sufficient capital to fund our plan of operations. In order to address our capital needs, including our planned clinical trials, we must continue to actively pursue additional equity or debt financing, government funding, and monetization of our existing programs through partnership arrangements or sales to third parties.

In June 2020, we were awarded $4.7 million from the U.S. Army Medical Research & Development Command (“USAMRDC”) to fund our Phase 1/2 clinical trial of T-COVID. The competitive award was granted by USAMRDC in collaboration with the Medical Technology Enterprise Consortium (“MTEC”), a 501(c)(3) biomedical technology consortium working in partnership with the Department of Defense (“DoD”). Under the contract, MTEC pays us a firm fixed fee based upon the achievement of certain milestones for conduct and completion of a Phase 1/2 study and research and development work on the replication-deficient adenovirus 5 (“RD-Ad5”) vector vaccine platform. Through ~~March 31,~~June 30, 2021, we have collected approximately ~~$1.6~~$1.1 million in cash under the contract.

In July 2016, we signed a five-year contract with BARDA. The contract, as amended, has a total value of up to $133.7 million and is used to fund clinical development of NasoShield. Under the contract, BARDA pays us a fixed fee and reimburses certain costs for the research and development of an Ad5-vectored, protective antigen-based intranasal anthrax vaccine through cGMP manufacture and conduct of a Phase 1 clinical trial dose ranging assessment of safety and immunogenicity. The contract consists of an initial base performance period providing approximately $27.8 million in funding for the period July 2016 through ~~December 2020.~~September 2021. BARDA has seven options to extend the contract to fund certain continued development and manufacturing activities for the anthrax vaccine, including Phase 2 clinical trials. Each option, if exercised by BARDA, would provide additional funding ranging from approximately $1.1 million to $34.4 million for a three-year period beginning January 2021. Through ~~March 31,~~June 30, 2021, we have collected approximately ~~$24.9~~$25.5 million in cash under the current BARDA contract.

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Cash Flows

The following table provides information regarding our cash flows for the ~~three~~six months ended ~~March 31,~~June 30, 2021 and 2020:

	Three Months Ended March 31,
	2021			2020
Net cash provided by (used in):

							Six Months Ended June 30,
							2021		2020
Net cash (used in) provided by:
Operating activities	$	(19,569,160	)	$	(4,347,401	)	$	(38,495,788)	$	(11,518,302)
Investing activities		19,165,095			6,563,216			44,242,251		12,661,500
Financing activities		34,418,645			96,713			52,438,112		54,636,037
Net increase in cash and cash equivalents and restricted cash	$	34,014,580		$	2,312,528		$	58,184,575	$	55,779,235

Operating Activities

Net cash used in operating activities was ~~$19.6~~$38.5 million for the ~~three~~six months ended ~~March 31,~~June 30, 2021 compared to ~~$4.3~~$11.5 million during the ~~three~~six months ended ~~March 31,~~June 30, 2020. Our sources of cash provided by operations during the ~~three~~six months ended ~~March 31,~~June 30, 2021 were primarily cash receipts of income tax refunds and revenue generated by our BARDA and MTEC contracts. The primary uses of cash from our operating activities include payments for labor and labor-related costs, professional fees, research and development costs associated with our clinical trials, and other general corporate expenditures. The increase in cash used in operations of ~~$15.2~~$27.0 million year over year is due to an increase in net loss as adjusted for non-cash items of ~~$10.8~~$22.5 million and changes in working capital accounts of $4.4 million.

Investing Activities

Net cash provided by investing activities was ~~$19.2~~$44.2 million for the ~~three~~six months ended ~~March 31,~~June 30, 2021 compared to ~~$6.6~~$12.7 million during the ~~three~~six months ended ~~March 31,~~June 30, 2020. The net cash provided by investing activities during the ~~three~~six months ended ~~March 31,~~June 30, 2021 was primarily due to net proceeds from short-term investment activity, partially offset by purchases of property and equipment. The net cash provided by investing activities during the ~~three~~six months ended ~~March 31,~~June 30, 2020 was primarily due to net proceeds from short-term investment activity.

Financing Activities

Net cash provided by financing activities during the ~~three~~six months ended ~~March 31,~~June 30, 2021 was ~~$34.4~~$52.4 million compared to ~~$0.1~~$54.6 million for the ~~three~~six months ended ~~March 31,~~June 30, 2020. The net cash provided by financing activities during the ~~three~~six months ended ~~March 31,~~June 30, 2021 was primarily the result of the receipt of ~~$34.2~~$52.4 million in proceeds from the issuance of common stock from our at-the-market ~~offering program and $0.1 million in proceeds from the~~ ~~issuance of common stock from our Employee Stock Purchase Plan~~.offerings program. The net cash provided by financing activities during the ~~three~~six months ended ~~March 31,~~June 30, 2020 was primarily the result of $31.3 million in proceeds from the exercise of warrants and $22.8 million in proceeds from the issuance of common stock from our ~~Employee Stock Purchase Plan and exercise of warrants.~~at-the-market offerings program.

Financing

Public Offering

On July 16, 2020, we offered and sold (i) 3,369,564 shares of our common stock, at a price to the public of $23.00 per share, and (ii) pre-funded warrants to purchase 1,630,436 shares of our common stock at an exercise price equal to $0.0001 per share (the “Pre-Funded Warrants”), at a price to the public of $22.9999 per share of common stock underlying the Pre-Funded Warrants (equal to the public offering price per share of Common Stock, minus the exercise price of each Pre-Funded Warrant). The Pre-Funded Warrants are exercisable at any time, provided that each Pre-Funded Warrant holder will be prohibited from exercising such Pre-Funded Warrants into shares of our common stock if, as a result of such exercise, the holder, together with its affiliates, would own more than 4.99% of the total number of shares of our common stock then issued and outstanding, which percentage may change at the holders’ election to any other number less than or equal to 19.99% upon 61 days’ notice to us. The gross proceeds of this offering were approximately $132.2 million, which includes the exercise in full of the underwriters’ option to purchase an additional 750,000 shares of common stock, before

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deducting underwriting discounts and commissions and offering expenses during the third quarter of 2020. The net proceeds of this offering were approximately $124.0 million, after deducting underwriting discounts and commissions and offering expenses payable by the Company.

At-the-Market Offerings

On February 25, 2021, we entered into an Equity Distribution Agreement (the “2021 Agreement”) with Piper Sandler & Co., Evercore Group L.L.C., and B. Riley Securities, Inc., serving as sales agents (the “Sales Agents”) with respect to an at-the-market ~~offering~~offerings program under which we may offer and sell, from time to time at its sole discretion, shares of our common stock, par value $0.0001 per share (the “Common Stock”), having an aggregate offering price of up to $125.0 million (the “Shares”) through the Sale Agents (the “2021 Offering”). As of ~~March 31,~~June 30, 2021, we sold ~~2,110,800~~3,516,510 shares of Common Stock under the 2021 Agreement resulting in approximately ~~$34.2~~$52.4 million in net proceeds, with ~~$89.7~~$70.9 million remaining available to be sold under the 2021 Agreement.

On March 27, 2020, we entered into an Equity Distribution Agreement (the “2020 Agreement”) with JMP Securities LLC, serving as placement agent (the “Placement Agent”) with respect to an at-the-market ~~offering~~offerings program under which we may offer and sell, from time to time at our sole discretion, shares of our common stock, par value $0.0001 per share (the “Common Stock”), having an aggregate offering price of up to $50.0 million (the “Shares”) through the Placement Agent (the “2020 Offering”). We offered Shares having an aggregate offering price of

~~$18.9~~ $18.9 million pursuant to the prospectus supplement filed with the SEC on March 27, 2020. On June 1, 2020, we filed an amendment to the 2020 Agreement which amended the prospectus supplement dated March 27, 2020 to increase the aggregate offering price to $50.0 million. As of ~~March~~June 30, 2021, the 2020 Agreement was fully utilized.

Current Resources

We have financed our operations to date principally through our equity offerings and proceeds from issuances of our preferred stock, common stock, and warrants. At ~~March 31,~~June 30, 2021,, we had ~~$150.0~~$174.1 million of cash, cash equivalents and restricted cash and ~~$76.6~~$43.7 million of short-term investments. Accordingly, management believes that the Company has sufficient capital to fund its plan of operations for at least a twelve-month period from the issuance date of our ~~March 31,~~June 30, 2021 financial statements. However, in order to address our capital needs in the long-term, including our planned clinical trials, we must continue to actively pursue additional equity or debt financing, government funding, and monetization of our existing programs through partnership arrangements or sales to third parties.

Off-Balance Sheet Arrangements

As of ~~March 31,~~June 30, 2021, we did not have any relationships with unconsolidated entities or financial partnerships, such as entities often referred to as “special purpose” entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes.

Item 3. Quantitative and Qualitative Disclosures about Market Risk

As a “smaller reporting company” as defined by Item 10 of Regulation S-K, we are not required to provide the information required by this Item.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and principal financial officer, evaluated the effectiveness of our disclosure controls and procedures pursuant to Rule 13a-15 under the Securities Exchange Act of 1934, as amended (“the “Exchange Act”) as of the end of the period covered by this Quarterly Report on Form 10-Q.

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Based on this evaluation, our principal executive officer and principal financial officer concluded that, as of ~~March 31,~~June 30, 2021, our disclosure controls and procedures were effective to provide reasonable assurance that information we are required to disclose in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.

Changes in Internal Control Over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rule 13a-15(f) and Rule 15d-15(f) under the Exchange Act) during the quarter ended ~~March 31,~~June 30, 2021 identified in connection with the evaluation thereof by our management, including the Chief Executive Officer and Chief Financial Officer, that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

PART II. OTHER INFORMATION

~~OTHER INFORMATION~~

Item 1. Legal Proceedings

In December 2019, a complaint was filed by Dr. De-Chu Christopher Tang (“Plaintiff”) against us in the United States District Court for the Eastern District of Texas. The Plaintiff amended the complaint in February 2020 to include Vipin K. Garg and David J. Drutz as defendants, in addition to the Company (Dr. Garg, Dr. Drutz, and the Company are collectively referred to as “Defendants”). See Note 16 to the consolidated financial statements appearing in Item 1 of this report for further details.None.

Item 1A. Risk Factors

There have been no material changes from the risk factors disclosed in our Annual Report on Form 10-K filed with the SEC on February 25, 2021.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

On February 25, 2021, we entered into an exchange agreement (the “Exchange Agreement”) with entities affiliated with Venrock Healthcare Capital Partners III, L.P. (the “Exchanging Stockholders”), pursuant to which we exchanged an aggregate of 1,000,000 shares of our common stock, par value $0.0001 per share, (the “Common Stock”) owned by the Exchanging Stockholders for pre-funded warrants (the “Exchange Warrants”) to purchase an aggregate of 1,000,000 shares of Common Stock (subject to adjustment in the event of stock splits, recapitalizations and other similar events affecting common stock), with an exercise price of $0.0001 per share. The Exchange Warrants are exercisable at any time, except that the Exchange Warrants will not be exercised by the Exchanging Stockholders if, upon giving effect or immediately prior thereto, the Exchanging Stockholders would beneficially own more than 9.99% of the total number of issued and outstanding Common Stock, which percentage may change at the holders’ election to any other number less than or equal to 19.99% upon 61 days’ notice to us. The holders of the Exchange Warrants will not have the right to vote on any matter except to the extent required by Delaware law. The Exchange Warrants were issued in reliance of Section 3(a)(9) of the Securities Act of 1933, as amended.Not applicable.

Item 3. Default upon Senior Securities

None.

Item 4. Mine Safety Disclosures

Not applicable.

Item 5. Other Information

None.

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Item 6.Exhibits


	Exhibit Index

Exhibit No.	Description

10.1 §	Amendment No. 7 Contract Award issued by the Biomedical Advanced Research and Development Authority of the United Sates Department of Health and Human Services, dated June 29, 2021

~~4.1~~31.1 †	~~Form of Pre-funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Form 8-K, filed on February 25, 2021)~~

~~10.1~~	~~Amendment No. 6 tothe Second Restated License Agreement, effective as of January 22, 2021, between Janssen Vaccines & Prevention B.V. (formerly Crucell Holland B.V.) and Altimmune, Inc.~~

~~10.2~~ §	~~Statement of Work, dated March 9, 2021, by and between Altimmune, Inc. and Lonza Houston Inc.~~

~~31.1~~ †	Certification of Principal Executive Officer Pursuant to SEC Rule 13a-14(a)/15d-14(a)

31.2 †	Certification of Principal Financial Officer Pursuant to SEC Rule 13a-14(a)/15d-14(a)

32.1 †	Certification Pursuant to Section 1350 of Chapter 63 of Title 18 of the United States Code

32.2 †	Certification Pursuant to Section 1350 of Chapter 63 of Title 18 of the United States Code

101.INS	Inline XBRL Instance Document	(the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document)

101.SCH	Inline XBRL Taxonomy Extension Schema Document

101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document

101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document

101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document

104	Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)

†

This certification will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section. Such certification will not be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, except to the extent specifically incorporated by reference into such filing.

§	Certain portions of this exhibit have been omitted pursuant to a request for confidential treatment.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused the report to be signed on its behalf by the undersigned, thereunto duly authorized.


	ALTIMMUNE, INC.

Dated: ~~May 17,~~August 10, 2021	By:	/s/ Vipin K. Garg
	Name:	Vipin K. Garg
	Title:	President and Chief Executive Officer (Principal Executive Officer)

Dated: ~~May 17,~~August 10, 2021	By:	/s/ Will Brown
	Name:	Will Brown
	Title:	Chief Financial Officer (Principal Financial and Accounting Officer)


		Page

PART I. FINANCIAL INFORMATION

Item 1.	Financial Statements	1

	Consolidated Balance Sheets as of ~~March 31,~~June 30, 2021 (unaudited) and December 31, 2020	1

	Consolidated Statements of Operations and Comprehensive Loss for the three and six months ended ~~March 31,~~June 30, 2021 and ~~2019~~2020 (unaudited)	2

	Consolidated Statements of Changes in Stockholders’ Equity for the three and six months ended ~~March 31,~~June 30, 2021 and 2020 (unaudited)	3

	Consolidated Statements of Cash Flows for the ~~three~~six months ended ~~March 31,~~June 30, 2021 and 2020 (unaudited)	45

	Notes to Consolidated Financial Statements (unaudited)	56

Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	1417

Item 3.	Quantitative and Qualitative Disclosures about Market Risk	1823

Item 4.	Controls and Procedures	1823


PART II. OTHER INFORMATION

Item 1.	Legal Proceedings	1924

Item 1A.	Risk Factors	1924

Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	1924

Item 3.	Defaults Upon Senior Securities	1924

Item 4.	Mine Safety Disclosures	1924

Item 5.	Other Information	1924

Item 6.	Exhibits	2025

	Signatures	2126

	March 31, 2021			December 31, 2020
	(unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	149,932,387		$	115,917,807
Restricted cash		34,174			34,174
Total cash, cash equivalents and restricted cash		149,966,561			115,951,981
Short-term investments		76,574,768			100,005,558
Accounts receivable		4,801,428			4,610,202
Tax refund receivable		7,898,067			7,762,793
Prepaid expenses and other current assets		5,950,999			1,926,675
Total current assets		245,191,823			230,257,209
Property and equipment, net		5,198,052			1,056,920
Right of use asset		866,336			903,825
Intangible assets, net		12,879,247			12,823,846
Other assets		115,300			73,413
Total assets	$	264,250,758		$	245,115,213
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	418,243		$	612,293
Accrued expenses and other current liabilities		9,405,649			11,408,154
Total current liabilities		9,823,892			12,020,447
Contingent consideration		6,270,000			5,390,000
Other long-term liabilities		1,719,438			1,828,443
Total liabilities		17,813,330			19,238,890
Commitments and contingencies (Note 16)
Stockholders’ equity:
Common stock, $0.0001 par value; 200,000,000 shares authorized; 38,257,180 and 37,142,946 shares issued and outstanding at March 31, 2021 and December 31, 2020, respectively		3,810			3,697
Additional paid-in capital		462,417,706			417,337,742
Accumulated deficit		(210,944,707	)		(186,420,599	)
Accumulated other comprehensive loss, net		(5,039,381	)		(5,044,517	)
Total stockholders’ equity		246,437,428			225,876,323
Total liabilities and stockholders’ equity	$	264,250,758		$	245,115,213

	Common Stock						Additional Paid-In			Accumulated			Accumulated Other Comprehensive			Total Stockholders’
	Shares			Amount			Capital			Deficit			Loss			Equity
Balance at December 31, 2020		37,142,946		$	3,697		$	417,337,742		$	(186,420,599	)	$	(5,044,517	)	$	225,876,323
Stock-based compensation		—			—			1,218,351			—			—			1,218,351
Vesting of restricted stock awards including withholding, net		(6,349	)		1			(92,507	)		—			—			(92,506	)
Issuance of common stock from Employee Stock Purchase Plan		8,733			1			106,000			—			—			106,001
Retirement of common stock in exchange for common stock warrant		(1,000,000	)		(100	)		(7,539,900	)		(9,660,000	)		—			(17,200,000	)
Issuance of common stock warrant in exchange for retirement of common stock		—			—			17,200,000			—			—			17,200,000
Issuance of common stock in at the market offering, net		2,110,800			211			34,178,020			—			—			34,178,231
Issuance of common stock upon cashless exercise of warrants		1,050			—			10,000			—			—			10,000
Unrealized income on short-term investments		—			—			—			—			5,136			5,136
Net loss		—			—			—			(14,864,108	)		—			(14,864,108	)
Balance at March 31, 2021		38,257,180		$	3,810		$	462,417,706		$	(210,944,707	)	$	(5,039,381	)	$	246,437,428

Unobservable input	Value or Range	Weighted Average
Expected volatility	117.4%	117.4%
Risk-free interest rate	0.09%	0.09%
Cost of capital	30%	30%
Discount for lack of marketability	16%-19%	18%
Probability of payment	63%	63%
Projected year of payment	2022	2022