UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 20-F



£	REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934



S	ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, ~~2011~~2012



£	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to



£	SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report

Commission File Number 0-28564

QIAGEN N.V.

(Exact name of Registrant as specified in its charter)

n/a

(Translation of Registrant’s name in English)

The Netherlands

(Jurisdiction of incorporation or organization)

Spoorstraat 50

5911 KJ Venlo

The Netherlands

011-31-77-320-8400

(Address of principal executive offices)

Roland Sackers, Tel: ~~(240) 686-7700,~~011-31-77-320-8400, Fax: ~~(240) 686-7772~~011-31-77-320-8409

QIAGEN N.V., ~~19300 Germantown Rd., Germantown, Maryland 20874~~Spoorstraat 50, 5911 KJ Venlo, The Netherlands

(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)

Securities registered or to be registered pursuant to Section 12(b) of the Act:



Title of class: Common Shares, par value EUR 0.01 per share		Name of each exchange on which registered: NASDAQ Stock Market LLC

Securities registered or to be registered pursuant to Section 12(g) of the Act:

None

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act:

None

The number of outstanding Common Shares as of December 31, ~~2011~~2012 was ~~234,220,808.~~234,543,793.

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. ý Yes ¨ No

If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. ¨ Yes ý No

Note—Checking the box above will not relieve any registrant required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 from their obligations under those Sections.

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ý Yes ¨ No

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). ý Yes ¨ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer ý Accelerated filer ¨ Non-accelerated filer ¨

Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:



ý	U.S. GAAP
¨	International Financial Reporting Standards as issued by the International Accounting Standards Board
¨	Other

If “Other” has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow:



¨	Item 17
¨	Item 18

If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ¨ Yes ý No

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Unless the context otherwise requires, references herein to “we,” “us,” “our,” the “Company” or to “QIAGEN” are to QIAGEN N.V. and its consolidated subsidiaries.

EXCHANGE RATES

QIAGEN publishes its financial statements in U.S. dollars. In this Annual Report on Form 20-F, references to “dollars” or “$” are to U.S. dollars, and references to “EUR” or the “euro” are to the European Monetary Union euro. Except as otherwise stated herein, all monetary amounts in this Annual Report on Form 20-F have been presented in U.S. dollars.

The exchange rate used for the euro was obtained from the European Central Bank and is based on a regular daily concentration procedure between central banks across Europe and worldwide, which normally takes place at 2:15 P.M. Central European Time. This rate at March ~~26, 2012,~~1, 2013, was ~~$1.3276~~$1.3000 per ~~EUR 1.~~€1.

For information regarding the effects of currency fluctuations on our results, see Item 5 “Operating and Financial Review and Prospects.”

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TABLE OF CONTENTS



	PART I
		Page
Item 1.	Identity of Directors, Senior Management and Advisors	4
Item 2.	Offer Statistics and Expected Timetable	4
Item 3.	Key Information	4
Item 4.	Information on the Company	1819
Item 4A.	Unresolved Staff Comments	3032
Item 5.	Operating and Financial Review and Prospects	3032
Item 6.	Directors, Senior Management and Employees	4144
Item 7.	Major Shareholders and Related Party Transactions	5154
Item 8.	Financial Information	5255
Item 9.	The Offer and Listing	5255
Item 10.	Additional Information	5457
Item 11.	Quantitative and Qualitative Disclosures about Market Risk	6770
Item 12.	Description of Securities Other than Equity Securities	6871

	PART II

Item 13.	Defaults, Dividend Arrearages and Delinquencies	6972
Item 14.	Material Modifications to the Rights of Security Holders and Use of Proceeds	6972
Item 15.	Controls and Procedures	6972
Item 16A.	Audit Committee Financial Expert	7073
Item 16B.	Code of Ethics	7073
Item 16C.	Principal Accountant Fees and Services	7073
Item 16D.	Exemptions from the Listing Standards for Audit Committees	7073
Item 16E.	Purchases of Equity Securities by the Issuer and Affiliated Purchasers	7073
Item 16F.	Change in Registrant’s Certifying Accountant	7174
Item 16G.	Corporate Governance	7174
Item 16H.	Mine Safety Disclosure	7276
	PART III

Item 17.	Financial Statements	7377
Item 18.	Financial Statements	7377
Item 19.	Exhibits	7377
	Signatures	7579

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PART I


Item 1.	Identity of Directors, Senior Management and Advisors

Not applicable.


Item 2.	Offer Statistics and Expected Timetable

Not applicable.


Item 3.	Key Information

QIAGEN N.V. is registered under its commercial and legal name with the trade register (kamer van koophandel) of the Dutch region Limburg Noord under file number 12036979. QIAGEN N.V. is a public limited liability company (naamloze vennootschap) under Dutch law as a holding company.

The selected consolidated financial data below should be read in conjunction with “Operating and Financial Review and Prospects” and the Consolidated Financial Statements, including the notes and other financial information included in this Annual Report on Form 20-F. The selected financial data below is derived from the consolidated statements of income for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010 and the consolidated balance sheets at December 31, ~~2011~~2012 and ~~2010~~2011 of QIAGEN that have been audited by an independent registered public accounting firm, and are included in this Annual Report. The selected data from the consolidated statements of income presented for the years ended December 31, ~~2008~~2009 and ~~2007,~~2008, and the consolidated balance sheets as of December 31, 2010, 2009 ~~2008~~ and ~~2007,~~2008, is derived from audited consolidated financial statements not included in this Annual Report. The 2010, 2009 and 2008 amounts for working capital, total assets and total long-term liabilities, including current portion, have been adjusted to correctly reflect deferred taxes as current or non-current and to net deferred tax positions within the same tax jurisdictions. These balance sheet reclassifications had no effect on total equity at December 31, 2010, 2009 and 2008.

Selected Financial Data

The information below should be read in conjunction with the Consolidated Financial Statements (and accompanying notes) and ~~“Operating~~"Operating and Financial Review and Prospects.”"

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	Years ended December 31,															Years ended December 31,
	2011			2010			2009			2008			2007			2012			2011			2010			2009			2008
Consolidated Statement of Income Data: (amounts in thousands, except per share data)
Net sales	$	1,169,747		$	1,087,431		$	1,009,825		$	892,975		$	649,774		$	1,254,456		$	1,169,747		$	1,087,431		$	1,009,825		$	892,975
Cost of sales	419,938			371,869			342,752			293,285			216,227			430,432			419,938			371,869			342,752			293,285
Gross profit	749,809			715,562			667,073			599,690			433,547			824,024			749,809			715,562			667,073			599,690
Operating Expenses:
Research and development	130,636			126,040			107,900			97,331			64,935			122,476			130,636			126,040			107,900			97,331
Sales and marketing	307,332			267,484			244,814			227,408			164,690			343,549			307,332			267,484			244,814			227,408
General and administrative, integration and other	185,507			110,009			115,933			113,936			87,178			152,068			185,507			110,009			115,933			113,936
Acquisition-related intangible amortization	26,746			23,492			18,221			14,368			7,711			36,117			26,746			23,492			18,221			14,368
Purchased in-process research and development	—			—			—			985			25,900			—			—			—			—			985
Total operating expenses	650,221			527,025			486,868			454,028			350,414			654,210			650,221			527,025			486,868			454,028
Income from operations	99,588			188,537			180,205			145,662			83,133			169,814			99,588			188,537			180,205			145,662
Other expense	(3,376		)	(15,416		)	(7,875		)	(26,376		)	(7,407		)	(24,661		)	(3,376		)	(15,416		)	(7,875		)	(26,376		)
Income before provision for income taxes	96,212			173,121			172,330			119,286			75,726			145,153			96,212			173,121			172,330			119,286
Provision for income taxes	1,263			28,810			34,563			29,762			25,555			15,616			1,263			28,810			34,563			29,762
Net income	$	94,949		$	144,311		$	137,767		$	89,524		$	50,171		$	129,537		$	94,949		$	144,311		$	137,767		$	89,524
Net (loss) income attributable to noncontrolling interest	(1,089		)	—			—			491			49
Net income (loss) attributable to noncontrolling interest																31			(1,089		)	—			—			491
Net income attributable to QIAGEN N.V.	$	96,038		$	144,311		$	137,767		$	89,033		$	50,122		$	129,506		$	96,038		$	144,311		$	137,767		$	89,033
Basic net income per common share attributable to the owners of QIAGEN N.V. (1)	$	0.41		$	0.62		$	0.67		$	0.45		$	0.30		$	0.55		$	0.41		$	0.62		$	0.67		$	0.45
Diluted net income per common share attributable to the owners of QIAGEN N.V. (1)	$	0.40		$	0.60		$	0.64		$	0.44		$	0.28		$	0.54		$	0.40		$	0.60		$	0.64		$	0.44
Weighted-average common shares outstanding
Basic	233,850			232,635			206,928			196,804			168,457			235,582			233,850			232,635			206,928			196,804
Diluted	239,064			240,483			213,612			204,259			175,959			240,746			239,064			240,483			213,612			204,259

____________________


(1)	See Note 319 of the “Notes to Consolidated Financial Statements” for the computation of the weighted average number of Common Shares.



	As of December 31,
	2012		2011		2010		2009		2008
Consolidated Balance Sheet Data: (amounts in thousands)
Cash and cash equivalents	$	394,037	$	221,133	$	828,407	$	825,557	$	333,313
Working capital⁽¹⁾	$	725,752	$	293,753	$	1,003,489	$	972,183	$	446,117
Total assets	$	4,087,631	$	3,729,685	$	3,878,478	$	3,769,219	$	2,810,789
Total long-term liabilities, including current portion	$	1,101,550	$	725,874	$	1,118,932	$	1,171,065	$	1,128,301
Total equity	$	2,724,363	$	2,557,798	$	2,476,353	$	2,291,169	$	1,453,844
Common shares, par value	$	2,769	$	2,739	$	2,724	$	2,711	$	2,212
Common shares outstanding	236,487		234,221		233,115		232,074		197,839

_________________

(1) Working capital is current assets less current liabilities.

Risk Factors

Risk Management

Our risk management approach embodies the key elements of a sound risk management system including (1) active board and senior management involvement; (2) adequate policies and procedures; (3) adequate risk management, monitoring

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and information systems; and (4) comprehensive internal controls.

The Company is managed by a Managing Board and an independent Supervisory Board appointed by the General Meeting of Shareholders. One of the Managing Board's responsibilities is the oversight of the Company's risk management system. The Managing Board has developed and implemented strategies, controls and mitigation measures to identify current and developing risks as part of our risk management system. Risk management policies and procedures and embodied in our corporate governance, code of ethics and financial reporting controls and procedures. A variety of functional experts evaluate these business risks, attempting to mitigate and manage these risks on an ongoing basis.

Identified risks are subdivided into three types:

A base business risk one is specific to us or our industry and that threatens our current and existing business;

A business growth risk is a risk specific to us or our industry that threatens our future business growth; and

An underlying business risk, which comprises risks that are not specific to us or our industry but apply to a larger number of public companies.

All identified risks are evaluated based on their likelihood of occurring and their potential impact (estimated in monetary terms) in disrupting our progress in achieving our business objectives. The overall risk management goal is to identify risks that could significantly threaten our success and to allow management on a timely basis the opportunity to successfully mitigate such risks. The results of the risk assessment and any updates are reported to the Audit Committee on a regular basis. Each quarter a detailed risk reporting update is provided to the Audit Committee for specific risks which have been newly identified or have changed since the last assessment. On a semi-annual basis the overall risk inventory is updated for all risks that are categorized as either a base business risk or a risk to business growth. A detail review of all underlying business risks is done every year. At least once a year, the Supervisory Board discusses the corporate strategy and business risks as well as the results of an assessment by the Managing Board and the Audit Committee on the structure and operations of the internal risk management and control systems, including any significant changes.

Our corporate governance structure is based on a strong framework of the responsibilities of our Managing and Supervisory Boards (discussed in more detail in Item 10 of this Annual Report) and the function of the Audit Committee of the Supervisory Board (discussed in more detail in Item 6 of this Annual Report). We maintain an adequate internal control over financial reporting to ensure the integrity of financial reporting as described further in Item 15 of this Annual Report. Additionally, we maintain a Compliance Committee under the leadership of the Chief Financial Officer, who is also a member of the Managing Board. The Compliance Committee consists of senior executives from various functional areas who are responsible to ensure compliance with legal and regulatory requirements in addition to overseeing the communication of corporate policies, including our Code of Ethics as described further in Item 16B of this Annual Report.

As of December 31,
2011 2010 2009 2008 2007
Consolidated Balance Sheet Data:
(amounts in thousands)

Cash and cash equivalents $ 221,133
$ 828,407
$ 825,557
$ 333,313
$ 347,320
Working capital (1) $ 266,775
$ 976,181
$ 957,940
$ 441,180
$ 482,215
Total assets $ 3,756,453
$ 3,913,995
$ 3,796,464
$ 2,885,323
$ 2,775,174
Total long-term liabilities, including current portion $ 722,621
$ 1,125,070
$ 1,183,182
$ 1,197,088
$ 1,220,084
Total equity $ 2,557,798
$ 2,476,353
$ 2,291,169
$ 1,453,844
$ 1,391,575
Common shares, par value $ 2,739
$ 2,724
$ 2,711
$ 2,212
$ 2,175
Common shares outstanding 234,221
233,115
232,074
197,839
195,335



Risk Types
Base Business Risk	• Identification and monitoring of competitive threats to the business • Monitoring complexity of product portfolio • Monitoring dependence on key customers for single product groups • Dependence on individual production sites or suppliers • Evaluating purchasing initiatives, price controls and changes to reimbursements • Monitoring of production risks, including contamination prevention, high-quality product assurance • Ensuring ability to defend against intellectual property infringements and maintain competitive advantage after expiration
Business Growth Risk	• Managing development and success of key R&D projects • Managing successful integration of acquisitions to achieve anticipated benefits
Underlying Business Risk	• Financial Risks including Economic risk and fluctuations in currency exchange rates • Financial Reporting Risk including monitoring multi-jurisdiction tax compliance • Evaluating possible asset impairment events • Compliance and Legal risks including safety in operations and environmental hazard risks, compliance with various regulatory bodies and pending regulatory product approvals • Risks of FCPA or anti-trust concerns arising from a network of subsidiaries and distributors in foreign countries

~~_________________~~

~~(1) Working capital is current assets less current liabilities.~~

~~Risk Factors~~

~~Note Regarding Forward-Looking Statements and Risk Factors~~

~~Our future operating results may be affected by various risk factors, many of which~~The risks described below are ~~beyond our control. Certain statements included~~listed in ~~this Annual Report and~~ the documents incorporated herein by reference may be forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended, including statements regarding potential future net sales, gross profit, net income and liquidity. These statements can be identified by the use of forward-looking terminology such as “believe,” “hope,” “plan,” “intend,” “seek,” “may,” “will,” “could,” “should,” “would,” “expect,” “anticipate,” “estimate,” “continue” or other similar words. Reference is made in particular to the descriptionorder of our ~~plans and objectives for future operations, assumptions underlying such plans and objectives, and other forward-looking statements. Such statements are based on management’s~~ current ~~expectations and are subject to a number~~view of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. We caution investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors. Factors which could cause such results to differ materially from those described in the forward-looking statements include those set forth intheir expected significance. Describing the risk factors ~~below. As~~in order of significance does not imply that a ~~result,~~lower listed risk factor may not have a material adverse impact our ~~future success involves a high degree~~results of risk. When considering forward-looking statements, you should keep in mind that the risk factors could cause our actual results to differ significantly from those contained in any forward-looking statement.

~~Risks Related to the Growth of Our Business~~operations, liquidity or capital resources.

An inability to manage our growth, manage the expansion of our operations, or successfully integrate acquired

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businesses could adversely affect our business.

Our business has grown rapidly, with total net sales increasing to ~~nearly~~ $~~1.2~~1.25 billion in ~~2011~~2012 from $~~893.0 million~~1.01 billion in ~~2008.~~2009. We have made several acquisitions in recent years, including AmniSure in 2012 and Cellestis Ltd. ~~in August 2011~~ and ~~purchased a majority of~~ Ipsogen S.A. ~~shares~~ in ~~July~~ 2011. Other acquisitions include SABiosciences and DxS Ltd. in 2009; Corbett Life Science Pty. Ltd., or Corbett, in 2008; and Digene Corporation, or Digene, in 2007. We intend to identify and acquire other businesses in the future that support our strategy to build on our global leadership position in Sample & Assay ~~technologies.~~Technologies. The successful integration of acquired businesses requires a significant effort and expense across all operational areas.

We have also made significant investments to expand our business operations. In January 2009, we purchased land adjacent to our facility in Germany and in August 2009 began a major expansion project to create additional facilities for research and development as well as to expand production capacity. This expansion project was ~~substantially~~ completed ~~by the end of 2011.~~in early 2012. In addition, we began a project in June 2010 to expand our facility in Germantown, Maryland, for research, production and administrative space, and this project is expected to continue into 2014. These expansion projects increase our fixed costs, resulting in higher operational costs in the ~~future~~short term that will negatively impact our gross profit and operating income until we fully utilize the additional capacity of these planned facilities. We also continue to upgrade our operating and financial systems and expand the geographic presence of our operations, which has resulted in the reallocation of existing resources or the hiring of new employees as well as increased responsibilities for both existing and new management personnel. The rapid expansion of our business and the addition of new personnel may place a strain on our management and operational systems.

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Our future operating results will depend on the ability of our management to continue to implement and improve our research, product development, manufacturing, sales and marketing and customer support programs, enhance our operational and financial control systems, expand, train and manage our employee base, integrate acquired businesses, and effectively address new issues related to our growth as they arise. There can be no assurance that we will be able to manage our recent or any future expansion or acquisitions successfully, and any inability to do so could have a material adverse effect on our results of operations.

Our acquisitions expose us to new risks, and we may not achieve the anticipated benefits of acquisitions of technologies and businesses.

During the past several years, we have acquired and integrated a number of companies through which we have gained access to new technologies, products and businesses that complement our internally developed product lines. In the future, we expect to acquire additional technologies, products or businesses to expand our operations. Acquisitions expose us to new operating and other risks, including risks associated with the:

assimilation of new products, technologies, operations, sites and personnel;

application for and achievement of regulatory approvals or other clearances;

diversion of resources from our existing products, business and technologies;

generation of sales to offset associated acquisition costs;

implementation and maintenance of uniform standards and effective controls and procedures;

maintenance of relationships with employees and customers and integration of new management personnel;

issuance of dilutive equity securities;

incurrence or assumption of debt;

amortization or impairment of acquired intangible assets or potential businesses; and

exposure to liabilities of and claims against acquired entities.

Our failure to address the above risks successfully in the future may prevent us from achieving the anticipated benefits from any acquisition in a reasonable time frame, or at all.

Our continued growth is dependent on the development and success of new products.

Rapid technological change and frequent new product introductions are typical in the markets we serve. Our ~~future~~ success will depend in part on continuous, timely development and introduction of new products that address evolving market requirements. We believe successful new product introductions provide a significant competitive advantage because customers make an investment of time in selecting and learning to use a new product and are reluctant to switch thereafter. To the extent that we fail to introduce new and innovative products, or such products suffer significant delays in development or are not accepted in the market, we may lose market share to our competitors, which will be difficult or impossible to regain. An inability to successfully develop and introduce new products, for technological or other reasons, could reduce our growth rate or otherwise

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have an adverse effect on our business. In the past, we have experienced delays in the development and introduction of products, including regulatory approvals, and we may experience delays in the future.

As a result, we cannot assure you that we will keep pace with the rapid rate of change in our markets or that our new products will adequately meet the requirements of the marketplace, achieve market acceptance or regulatory approval or compete successfully with competitive technologies. Some of the factors affecting market acceptance of new products include:

availability, quality and price relative to competitive products;

the timing of introduction of the new product relative to competitive products;

opinions of the new product’s utility;

citation of the new product in published research;

regulatory trends and approvals; and

general trends in life sciences research, applied markets and molecular diagnostics.

The expenses or losses associated with unsuccessful product development activities or lack of market acceptance of our new products could materially adversely affect our business, financial condition and results of operations.

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Important new product programs underway include our modular medium-throughput QIAsymphony automation platform, our next generation sequencing platform and our high-throughput QIAensemble automation platform and related Sample & Assay Technologies.

The speed and level of adoption of our QIAsymphony platform will affect sales of instrumentation but also of sample and assay kits designed to run on this system. In 2011 we exceeded our goal of reaching an installed based of 550 QIAsymphony systems, driven by the global rollout of QIAsymphony RGQ, our complete sample-to-result platform that was launched in late 2010. We have established a target of more than 750 QIAsymphony systems installed by year-end 2012. The rollout of QIAsymphony is intended to drive the dissemination and increasing sales of sample and assay kits that run on this platform, and we are seeking regulatory approvals for a number of these new products. In turn, the availability and regulatory approval of more tests to run on QIAsymphony, especially molecular assays for specific diseases or companion diagnostics paired with new drugs, will influence the value of the instruments to prospective buyers. The risk of slower adoption of QIAsymphony or the complete QIAsymphony RGQ system could significantly affect sales of products designed to run on these platforms.

The launch of the QIAensemble Decapper in late 2011, similarly, is an automation platform that affects sales of our test kits, primarily to high-throughput laboratories that run our HPV test to screen women for risk of cervical cancer. The level of acceptance of this instrument in the marketplace, and the development of future enhancements for the QIAensemble system, could significantly affect sales of products designed to run in the high-throughput setting.

Global economic conditions could adversely affect our business, results of operations and financial condition.

Our results of operations could be materially affected by adverse general conditions in the global economy and global financial markets. In times of economic hardship or high unemployment, patients may decide to forego or delay routine tests, in particular ~~for~~ our HPV test used to screen women for risk of cervical cancer. Changes in the availability or reimbursement of our molecular diagnostic testing products by insurance providers and healthcare maintenance organizations could also have a significant adverse impact on our results of operations.

Access to financing in the global financial markets has also been adversely affected for many businesses during the recent challenging economic times and public debt crisis. The uncertainty surrounding the resolution of the economic and sovereign debt crisis in Europe continues to have a negative impact on financial markets and economic conditions more generally. Our customers may face internal financing pressures that adversely impact spending decisions, the ability to purchase our products or that lead to a delay in collection of receivables and thus negatively impact our cash flow. A severe or prolonged economic downturn could result in a variety of risks to our business that would adversely impact our results of operations, including the reduction or delay in planned improvements to healthcare systems in various countries, the reduction of funding for life sciences research, and intensified efforts by governments and healthcare payors regarding cost-containment efforts.

Our results of operations could also be negatively impacted by automatic U.S. government spending cuts ("sequestration") that may take effect in 2013. These conditions may add uncertainty to the timing and budget for investment decisions by our customers, particularly, researchers, universities, government laboratories and private foundations whose funding is dependent upon grants from government agencies, such as the National Institutes of Health and similar bodies.

As is the case for many businesses, we face the following risks in regard to financial markets:

severely limited access to financing over an extended period of time, which may limit our ability to fund our growth strategy and could result in delays to capital expenditures, acquisitions or research and development projects;

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failures of currently solvent financial institutions, which may cause losses from our short-term cash investments or our hedging transactions due to a counterparty’s inability to fulfill its payment obligations;

inability to refinance existing debt at competitive rates, reasonable terms or sufficient amounts; and

increased volatility or adverse movements in foreign currency exchange rates.

Our concentration of a significant portion of revenues in products related to HPV testing increases our dependence on that product group's success, our reliance on relationships with a relatively small number of customers particularly in the United States, and our reliance on a diversification strategy to increase sales in other product areas.

Contributions in ~~2011~~2012 from ~~global~~ sales in the United States of our HPV test products represent approximately ~~20%~~13% of our total net ~~sales, of which approximately 15% were in the United States.~~sales. While the ultimate decision to order this test is made by physicians in consultation with their patients, in the U.S. the test analysis is generally performed by reference laboratories, who in turn are the customers of QIAGEN in terms of ordering tests and related equipment. At present, a limited number of reference laboratories in the U.S. account for the majority of HPV test sales. In times of economic hardship or high unemployment patients may decide to forego or delay routine ~~tests, as was the case during the second half of 2010 and during much of 2011 in the U.S.~~tests. Further, the cost of HPV testing in the U.S. is reimbursed to reference laboratories by insurance providers and health maintenance organizations. If these insurance plans decide to limit the availability of payments for our test to their members, it could have a significant adverse impact on our results of operations. Growth in other areas through diversification and new product launches has reduced the proportion of total net sales coming from HPV tests in the U.S., but if we fail to further

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diversify, we could be at risk that under-performance of the HPV line or loss of a customer could materially affect results of operations.

Our sales of HPV products will be affected by the level of acceptance of HPV screening by physicians and laboratories.

Sales of our HPV-related Molecular Diagnostics products depend upon our ability to develop greater acceptance by physicians and laboratories of the clinical benefits of HPV screening as a necessary part of the standard of care for screening women for risk of cervical cancer, either alone or in conjunction with cytology-based tests (Pap ~~smears)~~tests). This applies to the U.S. as well as Europe and other markets around the world. Pap tests have been the principal means of cervical cancer screening since the 1940s. Our HPV test is supported by extensive clinical data showing its significant benefits in better identifying women at risk for cervical cancer than a Pap test alone, and prevailing standards of care in the U.S. now ~~recommend~~include HPV tests in conjunction with Pap tests. In the U.S. approximately ~~45%~~half of cervical cancer screening includes co-testing of molecular HPV tests along with Pap smears. These standards are also being adopted in other countries around the world. However, technological advances designed to improve quality control over sample collection and preservation, as well as to reduce the susceptibility of Pap tests to human error, may increase physician reliance on the Pap test and solidify its market position as the most widely used screening test.

HPV testing applies a new molecular-based approach that is different from the cytology-based approach (reviewing cells under a microscope) of the Pap test. Significant resources are required to educate physicians and laboratories about the patient benefits that can result from using HPV test products in addition to the Pap test, and to assist laboratory customers in learning how to use our HPV test products. The addition of our HPV test products to the Pap test for primary screening in the United States may be seen by some customers as adding unnecessary expense to traditional cervical cancer screening. As a result, our ability to continue to grow revenues from HPV testing in the U.S. and around the world depends on providing information on the proven benefits of using our molecular technologies to identify women at risk for cervical cancer

We may encounter delays in receipt, or limits in the amount, of reimbursement approvals and public health funding, which will impact our ability to grow revenues in the healthcare market.

Third-party payors are often reluctant to reimburse healthcare providers for the use of medical tests that involve new technologies or provide novel diagnostic information. In addition, third-party payors are increasingly limiting reimbursement coverage for medical diagnostic products and, in many instances, are exerting pressure on diagnostic product suppliers to reduce their prices. Since each third-party payor often makes reimbursement decisions on an individual patient basis, obtaining such approvals is a time-consuming and costly process that requires us to provide scientific and clinical data supporting the clinical benefits of each of our products. As a result, there can be no assurance that reimbursement approvals will be obtained. This process can delay the broad market introduction of new products, and could have a negative effect on our results of operations. As a result, third-party reimbursement may not be consistent or financially adequate to cover the cost of our products. This could limit our ability to sell our products or cause us to reduce prices, which would adversely affect our results of operations.

Reduction in research and development budgets and government funding may result in reduced sales.

Our customers include researchers at pharmaceutical and biotechnology companies, academic institutions, and government and private laboratories. Fluctuations in the research and development budgets of these organizations could have a significant adverse effect on demand for our products. Research and development budgets are affected by changes in available

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resources, the mergers of pharmaceutical and biotechnology companies, changes in spending priorities and institutional budgetary policies. Our results of operations could be adversely affected by any significant decrease in expenditures for life sciences research and development by pharmaceutical and biotechnology companies, academic institutions, and government and private laboratories. In addition, short-term changes in administrative, regulatory or purchasing-related procedures can create uncertainties or other impediments that can have an adverse impact on our results of operations.

In recent years, the pharmaceutical and biotechnology industries have undergone substantial restructuring and consolidation. Additional mergers or consolidation within the pharmaceutical and biotechnology industries could cause us to lose existing customers and potential future customers, which could have a material adverse impact on our results of operations.

Approximately 25% of our sales are generated from demand for our products used in the Academia customer class by researchers at universities, government laboratories and private foundations, and whose funding is dependent upon grants from government agencies, such as the U.S. National Institutes of Health (NIH). Although the level of research funding has been increasing in recent years, we cannot assure you that this trend will continue given federal and state budget constraints. Government funding of research and development is subject to the political process, which is inherently unpredictable. Future sales may be adversely affected if our customers delay purchases as a result of uncertainties regarding the approval of government or industrial budget proposals. Also, government proposals to reduce or eliminate budgetary deficits have

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sometimes included reduced allocations to the NIH and government agencies in other countries that fund life sciences research and development activities. A reduction in government funding for the NIH or government research agencies in other countries could have a serious adverse impact on our results of operations.

Competition could reduce our sales.

We face various competitive factors against greater adoption of our products, in particular the use of “home-brew” or lab-developed methods, where widely available reagents and other chemicals are used in a non-standardized manner to perform sample and assay processing. We are also aware that a significant number of laboratory organizations and ~~competitor companies~~competitors are developing and using their own internally developed molecular ~~assay~~ tests. Some competitor companies may seek regulatory approvals from the U.S. Food and Drug Administration (FDA) or similar non-U.S. regulatory authorities and bring to the market alternative products that could limit the use of our products. The success of our business depends in part on the continued conversion of current users of “home brew” methods to our standardized Sample & Assay Technologies and products. There can be no assurance, however, as to the continued conversion of these potential customers.

We have experienced, and expect to continue to experience, increasing competition from companies that provide competitive pre-analytical solutions and also other products used by our customers. The markets for some of our products are very competitive and price sensitive. Other product suppliers may have significant advantages in terms of financial, operational, sales and marketing resources as well as experience in research and development. These companies may have developed, or could develop in the future, new technologies that compete with our products or even render our products obsolete. The development of products offering superior technology or a more cost-effective alternative to our products could have a material adverse effect on our results of operations.

We believe that customers in the market for pre-analytical ~~solutions and~~sample technologies as well as for assay technologies display a significant ~~amount of~~ loyalty to their initial supplier of a particular product, in particular given the time and expense required by customers to properly ~~implement~~integrate these products into their operations. As a result, it may be difficult to convert customers who have purchased products from competitors, and our competitive position may suffer if we are unable to be the first to develop and supply new products.

~~Risks Related to the Development, Manufacture and Distribution of Our Products~~

The time and expense needed to obtain regulatory approval and respond to changes in regulatory requirements could adversely affect our ability to commercially distribute our products and generate sales.

We and our customers operate in a highly regulated environment characterized by continuous changes in the governing regulatory framework, particularly for product approvals. Genetic research activities and products commonly referred to as “genetically engineered” (such as certain food and therapeutic products) are subject to extensive governmental regulation in most developed countries, especially in the major markets for pharmaceutical and diagnostic products such as the European Union, the U.S. and Japan. In recent years, several highly publicized scientific events (most notably in genomic research and “cloning”) have prompted intense public debates on the ethical, philosophical and religious implications of an unlimited expansion in genetic research and the use of products emerging from this research. As a result of this debate, some key countries may increase existing regulatory barriers, which could adversely affect demand for our products and prevent us from fulfilling our growth expectations. Furthermore, there can be no assurance that any future changes of applicable regulations will not require further expenditures or an alteration, suspension or liquidation of our operations in certain areas, or even in their

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entirety.

Changes in the existing regulations or adoption of new requirements or policies could adversely affect our ability to sell our approved products or to seek approvals for new products in other countries around the world. ~~Future sales~~Sales of certain products now in development may be dependent upon us successfully conducting pre-clinical studies, clinical trials and other tasks required to gain regulatory approvals. These trials could be subject to extensive regulation by governmental authorities in the U.S., particularly the FDA, and regulatory agencies in other countries. These trials involve substantial uncertainties and could impact customer demand for our products.

In addition, certain products, especially those intended for use in in vitro diagnostics applications, require regulatory approvals in various countries. For example, since the European Union Directive 98/79/EC on in vitro diagnostic medical devices, or EU-IvD-D, went into effect in 2003, all products and kits used for in vitro diagnostic applications must be compliant with this directive. In addition to high-risk products such as HIV testing systems (list A of Annex II of the directive) or blood glucose testing systems (list B of Annex II of the directive), nucleic acid purification products, which are used in diagnostic workflows, are affected by this regulatory framework. The major goals of this directive are to standardize diagnostic procedures within the European Union, to increase reliability of diagnostic analysis and to enhance patient safety. If we fail to obtain any

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required clearance or approvals, it could significantly damage our business in these markets.

Additionally, we may be required to incur significant costs to comply with laws and regulations in the future, and changes or additions to existing laws or regulations may have a material adverse effect upon our business, financial condition and results of operations.

Several of our key products and programs are medical devices subject to extensive regulation by the FDA under the ~~Federal~~U.S. Food, Drug and Cosmetic Act. We plan to apply for FDA clearance or approval of additional products in the future as medical devices. Regulatory agencies in other countries also have medical device approval regulations that are becoming more extensive. These regulations govern most commercial activities associated with medical devices, including indications for the use of these products as well as other aspects that include product development, testing, manufacturing, labeling, storage, recordkeeping, advertising and promotion. Compliance with these regulations is expensive and time-consuming. Our HPV products were the first to obtain regulatory approval in the U.S. and in many European countries for clinical use in screening women for cervical cancer, which adds to our marketing expenses and increases the degree of regulatory review and oversight. The expense of submitting regulatory approval applications in multiple countries, as compared to our available resources, will impact the decisions we make about entering new markets.

Each medical device that we wish to distribute commercially in the U.S. will likely require us to seek either 510(k) clearance or approval of a pre-market approval application (PMA) from the FDA prior to marketing the device for in-vitro diagnostic use. Clinical trials related to our regulatory submissions take years to complete and represent a significant expense. The 510(k) clearance pathway usually takes from three to twelve months, but can take longer. The PMA pathway is more costly, lengthy and uncertain, and can take from one to three years, or longer. For example, it took more than four years to receive pre-market approval from the FDA for our HPV test product for use as a test for the presence of HPV in women with equivocal Pap test results and pre-market approval for the use of our HPV test as a primary adjunctive cervical cancer screening test to be performed in combination with the Pap test for women age 30 and older. The uncertain time period required for regulatory review increases our costs to develop new products and increases the risk that we will not succeed in introducing or selling new products in the U.S.

Our cleared or approved devices, including our diagnostic tests and related equipment, are subject to numerous post-approval requirements. We are subject to inspection and marketing surveillance by the FDA to determine our compliance with regulatory requirements. If the FDA determines that we have failed to comply, it can institute a wide variety of enforcement actions, ranging from warning letters to more severe sanctions such as fines, injunctions and civil penalties, recalls or seizures of our products, operating restrictions, partial suspension or total shutdown of production, denial of our requests for 510(k) clearance or pre-market approval of product candidates, withdrawal of 510(k) clearance or pre-market approval already granted and criminal prosecution. Any enforcement action by the FDA may affect our ability to commercially distribute these products in the U.S.

Some of our products are sold for research purposes in the U.S. We do not promote these products for clinical diagnostic use, and they are labeled “For Research Use Only” (RUO) or “for molecular biology applications”. If the FDA were to disagree with our designation of a product, we could be forced to stop selling the product until appropriate regulatory clearance or approval has been obtained. Further, some of our products are used in ~~“Laboratory Developed~~“Laboratory-Developed Tests” ~~(LDT)~~(LDTs), where laboratories use our materials for assays manufactured, validated and performed in house. We do not promote these products for clinical diagnostic use. ~~If the FDA were to stop the practice of LDTs, sales of our products in the U.S. could be adversely affected.~~

Further, the FDA has announced its intention to begin regulating lab-developed tests ~~(LDTs)~~ in a phased-in approach, but details of proposed regulations have not yet emerged. LDTs represent the majority of molecular tests currently in use in terms of volume, and our automation systems - particularly the QIAsymphony platform - are designed to accommodate the automation and validation of these tests. On the other hand, laboratories creating LDTs may use some of our materials in their tests. We do not promote these products for clinical diagnostic use, but if the FDA were to stop the use of LDTs or significantly limit their area of application, sales of some of our products in the U.S. could be adversely affected. The flexibility to handle LDTs is an advantage for these instruments. On the consumables side, LDTs can be competitors to our own commercially approved tests. We are pursuing a strategy of developing new content for our platforms partly by seeking regulatory approvals for new assays

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in Molecular Diagnostics, as well as approvals for these tests to run on QIAGEN instruments. We believe standardized tests that pass regulatory scrutiny may be attractive not only to reference laboratories and healthcare providers, but also to translational researchers in Pharma and Academia using molecular assays to develop and study products they expect to commercialize. On the other hand, laboratories creating LDTs may use some of our materials in their tests. We do not promote these products for clinical diagnostic use, but if the FDA were to stop the use of LDTs, sales of some of our products in the U.S. could be adversely affected. At this point the ultimate impact of potential new FDA policies on ~~lab-developed tests~~LDTs is ~~uncertain~~uncertain.

We depend on suppliers for materials used to manufacture our products, and if shipments from these suppliers are delayed or interrupted, we may be unable to manufacture our products.

We buy materials to create our products from a number of suppliers and are not dependent on any one supplier or group of suppliers for our business as a whole. However, key components of certain products, including certain instrumentation

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components and chemicals, are available only from a single source. If supplies from these vendors are delayed or interrupted for any reason, we may not be able to obtain these materials timely or in sufficient quantities or qualities in order to produce certain products, and this could have an adverse impact on our results of operations.

We rely on collaborative commercial relationships to develop some of our products.

Our long-term business strategy involves entering into strategic alliances as well as marketing and distribution arrangements with academic, corporate and other partners relating to the development, commercialization, marketing and distribution of certain of our existing and potential products. We may be unable to continue to negotiate these collaborative arrangements on acceptable terms, and these relationships also may not be scientifically or commercially successful. In addition, we may be unable to maintain these relationships, and our collaborative partners may pursue or develop competing products or technologies, either on their own or in collaboration with others.

For example, our Personalized Healthcare business includes projects with pharmaceutical and biotechnology companies to co-develop companion diagnostics paired with drugs that those companies either market currently or are developing for future use. The success of these co-development programs, including regulatory approvals for the companion diagnostics, depends upon the continued commitment of our ~~Pharma~~ partners to development of those drugs, the outcome of clinical trials for the drugs and diagnostics, and regulatory approvals of the paired diagnostic tests and drugs. In addition, the future level of sales for companion diagnostics that we bring to market depends, in some measure, on the commercial success of the relevant drugs. More companion diagnostics would be sold in combination with a widely prescribed drug than a drug with limited use. Hence, the future success of these diagnostics depends on our Pharma partners' actions and commercial success.

Some of our customers are requiring us to change our sales arrangements to lower their costs, and this may limit our pricing flexibility and harm our business.

Some of our customers have developed purchasing initiatives to reduce the number of vendors from which they purchase products to lower their supply costs. In some cases, these customers have established agreements with large distributors, which include discounts and direct involvement in the distributor’s purchasing process. These activities may force us to supply large distributors with our products at discounts in order to continue providing products to some customers. For similar reasons, many larger customers, including the U.S. government, have requested, and may request in the future, special pricing arrangements, which can include blanket purchase agreements. These agreements may limit our pricing flexibility, which could harm our business and affect our results of operations. For a limited number of customers, and at the customer’s request, we have conducted sales transactions through third-party online intermediaries to whom we are required to pay commissions. If sales grow through these intermediaries, it could have an adverse impact on our results of operations, particularly a negative impact on our gross profit.

We heavily rely on air cargo carriers and other overnight logistics services, and shipping delays or interruptions could harm our business.

Our customers in the scientific research markets typically only keep a modest inventory of our products on hand, and consequently require overnight delivery of purchases. As a result, we heavily rely on air cargo carriers and logistic suppliers. If overnight services are suspended or delayed, and other delivery carriers and logistic suppliers cannot provide satisfactory services, customers may suspend a significant amount of their work. The lack of adequate delivery alternatives would have a serious adverse impact on our results of operations.

~~Risks Related to Our Operations~~

Our success depends on the continued employment of our key personnel, any of whom we may lose at any time.

Our senior management consists ~~of an Executive Committee comprised~~ of the Managing Directors and our most senior executives responsible for core functions, and led by Mr. Peer Schatz, our Chief Executive Officer. The loss of Mr. Schatz ~~or any of our Managing Directors~~ could have a material adverse effect on our operations. Further, although we have not experienced any difficulties attracting or retaining key management and scientific staff, our ability to recruit and retain qualified, skilled employees will continue to be critical to our success. Given the intense competition for experienced scientists among pharmaceutical and biotechnology companies as well as academic and other research institutions, there can be no assurance that we will be able to attract and retain employees critical to our success on acceptable terms. Initiatives to expand QIAGEN will also require additional employees, including management with

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expertise in areas such as manufacturing and marketing, and the development of existing managers to lead a growing organization. The failure to recruit new employees, or develop existing employees, could have a material adverse impact on our results of operations.

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Our ability to accurately forecast our results during each quarter may be negatively impacted by the fact that a substantial percentage of our sales may be recorded in the final weeks or days of the quarter.

The markets we serve are typically characterized by a high percentage of purchase orders being received in the final few weeks or even days of each quarter. Although this varies from quarter to quarter, many customers make a large portion of their purchase decisions late in each quarter, in particular since it is during this period that they receive new information on both their budgets and requirements. As a result, even late in each quarter, we cannot predict with certainty whether our sales forecasts for the quarter will be achieved.

Historically, we have been able to rely on the overall pattern of customer purchase orders during prior periods to project with reasonable accuracy our anticipated sales for the current or coming quarters. However, if customer purchasing trends during a quarter vary from historical patterns as may occur with changes in market conditions, our quarterly financial results could deviate significantly from our projections. As a result, our sales forecasts for any given quarter may prove not to have been accurate. We also may not have sufficient, timely information to confirm or revise our sales projections for a specific quarter. If we fail to achieve our forecasted sales for a particular quarter, the value of our Common Shares could be adversely affected.

Changes in tax laws or their application could adversely affect our results of operations.

~~The integrated nature of our worldwide operations enables us to reduce the effective tax rate on our earnings since a portion of our earnings are taxed at more favorable rates in some jurisdictions.~~ Changes in tax laws or their application with respect to matters such as changes in ~~tax-rates,~~tax rates, transfer pricing and income allocation, utilization of tax loss carry forwards, intercompany dividends, controlled corporations, and limitations on tax relief allowed on the interest on intercompany debt, and changes to tax credit mechanisms, could increase our effective tax rate and adversely affect our results of operations.

~~The~~ Additionally, changes in other laws, such as the U.S. health care reform ~~law could affect our business, profitability and stock price.~~

~~Comprehensive healthcare reform~~ legislation that was signed into law in the U.S. in ~~2010. Although we cannot fully predict the many ways in which this healthcare reform might affect our business, the law imposes a 2.3%~~2010, may subject us to additional excise tax on certain transactions, including many sales of medical devices, which we expect will include the U.S. sales of our assays and instruments.This tax will apply to U.S. sales of all taxable medical devices occurring after December 31, 2012.taxes. The increased tax burden as a result of changes in law may adversely affect our results of operations.

We have a significant amount of debt that may adversely affect our financial condition.

We have a significant amount of debt ~~which creates significant~~and debt service obligations. A high level of indebtedness increases the risk that we may default on our debt obligations. We cannot assure you that we will be able to generate sufficient cash flow to pay the interest on our debt or that future working capital, borrowings or equity financing will be available to repay or refinance our debt. If we are unable to generate sufficient cash flow to pay the interest on our debt, we may have to delay or curtail our research and development programs. The level of our indebtedness could, among other things:

make it difficult for us to make required payments on our debt;

make it difficult for us to obtain any financing in the future necessary for working capital, capital expenditures, debt service requirements or other purposes;

limit our flexibility in planning for, or reacting to, changes in our business and the industry in which we compete; and

make us more vulnerable in the event of a downturn in our business.

Our business may require substantial additional capital, which we may not be able to obtain on terms acceptable to us, if at all.

Our future capital requirements and level of expenses will depend upon numerous factors, including the costs associated with:

marketing, sales and customer support efforts;

research and development activities;

expansion of our facilities;

consummation of possible future acquisitions of technologies, products or businesses;

demand for our products and services; and

repayment or refinancing of debt.

We currently anticipate that our short-term capital requirements will be satisfied by cash flow from our operations. As of

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December 31, ~~2011~~2012, we had ~~short-term debt of~~ ~~$142.3 million~~ ~~due and paid in January 2012 and~~ outstanding long-term loan facilities of approximately $~~447.6~~847.0 million, of which $~~1.6~~0.9 million iswas current and due in ~~2012.~~2013. Furthermore, as of December 31, ~~2011~~2012, we ~~have~~had capital lease obligations, including the current portion, of $~~23.5~~19.9 million, that expire in various years through 2018. We may need to refinance all or part of these liabilities before or at

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their contractual maturities.

We currently do not foresee that this will happen, but if at some point in time our existing resources should be insufficient to fund our activities, we may need to raise funds through public or private debt or equity financings. The funds for the refinancing of existing liabilities or for the ongoing funding of our business may not be available or, if available, not on terms acceptable to us. If adequate funds are not available, we may be required to reduce or delay expenditures for research and development, production, marketing, capital expenditures and/or acquisitions, which could have a material adverse effect on our business and results of operations. To the extent that additional capital is raised through the sale of equity or convertible securities, the issuance of any securities could result in dilution to our shareholders.

An impairment of goodwill and intangible assets could reduce our earnings.

At December 31, ~~2011~~2012, our consolidated balance sheet reflected approximately $~~1.7~~1.8 billion of goodwill and approximately $~~819.5~~853.9 million of intangible assets. Goodwill is recorded when the purchase price of a business exceeds the fair ~~market~~ value of the tangible and separately measurable intangible net assets. U.S. generally accepted accounting principles (U.S. GAAP) requires us to test goodwill for impairment on an annual basis or when events or circumstances occur indicating that goodwill might be impaired. Long-lived assets, such as intangible assets with finite useful lives, are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. The impairment review often cannot be done at the level of the individual asset and it must instead be applied to a group of assets. For the purpose of our annual goodwill impairment testing based on the current circumstances of how we manage our business, this group of assets is the Company as a whole. If we determine that any of our goodwill or intangible assets were impaired, we will be required to take an immediate charge to earnings and our results of operations could be adversely affected.

Exchange rate fluctuations may adversely affect our business and operating results.

Since we currently market our products throughout the world, a significant portion of our business is conducted in currencies other than the U.S. dollar, our reporting currency. As a result, fluctuations in value, relative to the U.S. dollar, of the currencies in which we conduct our business have caused and will continue to cause foreign currency transaction gains and losses. Foreign currency transaction gains and losses arising from normal business operations are charged against earnings in the period when incurred. We economically hedge a portion of the anticipated cash flow that we expect to exchange into other currencies, subject to our short-term financing needs. Due to the number of currencies involved, the variability of currency exposures and the potential volatility of currency exchange rates, we cannot predict the effects of future exchange rate fluctuations. While we may engage in foreign exchange hedging transactions to manage our foreign currency exposure, there can be no assurance that our hedging strategy will adequately protect our operating results from the effects of future exchange rate fluctuations.

Our strategic equity investments may result in losses.

We have made, and may continue to make, strategic investments in ~~complementary~~ businesses as opportunities arise. We periodically review the carrying value of these investments for impairment, considering factors that include the most recent stock transactions, book values from the most recent financial statements, and forecasts and expectations of the investee. The results of these valuations may fluctuate due to market conditions and other conditions over which we have no control.

Estimating the fair value of non-marketable equity investments in life science companies is inherently subjective. If actual events differ from our assumptions and other than temporary unfavorable fluctuations in the valuations of the investments are indicated, we could be required to write-down the investment. This could result in future charges on our earnings that could materially adversely affect our results of operations. It is uncertain whether or not we will realize any long-term benefits from these strategic investments.

Risk of price controls is a threat to our profitability.

The ability of many of our customers to successfully market their products depends in part on the extent to which reimbursement for the costs of these products is available from governmental health administrations, private health insurers and other organizations. Governmental and other third-party payors are increasingly seeking to contain healthcare costs and to reduce the price of medical products and services. As a result, the biotechnology, diagnostics and pharmaceutical industries are exposed to the potential risk of price controls by these entities. If there are not adequate reimbursement levels, our business and results of operations could be adversely affected.

~~Risks Related to Our Global Operations~~

Doing business internationally creates certain risks for our business.

Our business involves operations in several countries outside of the U.S. Our consumable manufacturing facilities are located in Germany, China, France, the United Kingdom and the U.S., and our instrumentation facilities are located in

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Switzerland. We source raw materials and subcomponents to manufacture our products from different countries. We have established sales subsidiaries in numerous countries including the U.S., Germany, Japan, the United Kingdom, France, Switzerland, Australia, Canada, the Netherlands, Sweden, Italy, Hong Kong, Singapore, Turkey, South Korea, Taiwan, Malaysia, China, Spain, Brazil, Mexico, Russia and India. In addition, our products are sold through independent distributors serving more than 40 other countries. Conducting and launching operations on an international scale requires close coordination of activities across multiple jurisdictions and time zones and consumes significant management resources. We have invested heavily in computerized information systems in order to manage more efficiently the widely dispersed components of our operations. If we fail to coordinate and manage these activities effectively, our business and results of operations will be adversely affected.

Our operations are subject to other risks inherent in international business activities, such as general economic conditions in the countries in which we operate, longer accounts receivable payment cycles in certain countries, overlap of different tax structures, unexpected changes in regulatory requirements,

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and compliance with a variety of foreign laws and ~~regulations, and longer accounts receivable payment cycles in certain countries.~~regulations. Other risks associated with international operations include import and export licensing requirements, trade restrictions, exchange controls and changes in tariff and freight rates, as may occur as a result of rising energy costs. As a result of these conditions, an inability to successfully manage our international operations could have a material adverse impact on our business and results of operations.

Our business in countries with a history of corruption and transactions with foreign governments increase the risks associated with our international activities.

Based on our international operations, we are subject to the U.S. Foreign Corrupt Practices Act, or the FCPA, the U.K. Bribery Act and other laws that prohibit improper payments or offers of payments to foreign governments and their officials and political parties by business entities for the purpose of obtaining or retaining business. We have operations, agreements with third parties and make sales in countries known to experience corruption. Further international expansion may involve increased exposure to such practices. Our activities in these countries create the risk of unauthorized payments or offers of payments by one of our employees, consultants, sales agents or distributors that could be in violation of various laws, including the FCPA, even though these parties are not always subject to our control. It is our policy to implement safeguards to discourage these practices by our employees and distributors. However, our existing safeguards and any future improvements may not prove to be effective, and our employees, consultants, sales agents or distributors may engage in conduct for which we might be held responsible. Violations of the FCPA and other laws may result in criminal or civil sanctions, which could be severe, and we may be subject to other liabilities, which could negatively affect our business, results of operations and financial condition.

~~Exchange rate fluctuations may adversely affect our business and operating results.~~

Since we currently market our products throughout the world, a significant portion of our business is conducted in currencies other than the U.S. dollar, our reporting currency. As a result, fluctuations in value, relative to the U.S. dollar, of the currencies in which we conduct our business have caused and will continue to cause foreign currency transaction gains and losses. Foreign currency transaction gains and losses arising from normal business operations are charged against earnings in the period when incurred. We hedge a portion of the anticipated cash flow that we expect to exchange into other currencies, subject to our short-term financing needs. Due to the number of currencies involved, the variability of currency exposures and the potential volatility of currency exchange rates, we cannot predict the effects of future exchange rate fluctuations. While we may engage in foreign exchange hedging transactions to manage our foreign currency exposure, there can be no assurance that our hedging strategy will adequately protect our operating results from the effects of future exchange rate fluctuations.

We have made investments in and are expanding our business into emerging markets and regions, which exposes us to ~~new~~ risks.

~~We have recently expanded our business into~~Our top seven emerging markets ~~in Asia,~~are Brazil, Russia, India, China, South ~~America~~Korea, Mexico and ~~Africa,~~Turkey and we expect to continue to focus on expanding our business in these or other fast-growing markets. In addition to the currency and international operation risks described above, our international operations are subject to a variety of risks that include those arising out of the economy, political outlook and language and cultural barriers in countries where we have operations or do business. In many of these emerging markets, we may be faced with several risks that are more significant than in other countries in which we have a history of doing business. These risks include economies that may be dependent on only a few products and are therefore subject to significant fluctuations, weak legal systems which may affect our ability to enforce contractual rights, exchange controls, unstable governments, and privatization or other government actions affecting the flow of goods and currency. In conducting our business, we move products from one country to another and may provide services in one country from a subsidiary located in another country. Accordingly, we are vulnerable to abrupt changes in customs and tax regimes that could have significant negative impacts on our results of operations.

Our global operations may be affected by actions of governments, global or regional economic developments, weather or transportation delays, natural disasters or other force majeure events (collectively, unforeseen events) which may negatively impact our suppliers, our customers or us.

Our business involves operations around the world. Our consumable manufacturing facilities are located in Germany, China, France, the United Kingdom and the U.S., and our instrumentation facilities are located in Switzerland. We have established sales subsidiaries in numerous countries and our products are sold through independent distributors serving more than 40 additional countries. Our facilities may be harmed by unforeseen events, and in the event we or our customers are affected by a disaster, we may experience delays or reductions in sales or production, or increased costs, or may be required to identify alternate suppliers or rely on third-party manufacturers.

Our instrumentation manufacturing processes are dependent upon certain components provided by third-party suppliers

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located in Japan, which experienced a severe earthquake followed by a tsunami in March 2011. ~~As a result, to~~To the extent that

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our suppliers are impacted by ~~an event,~~a natural disaster or other disruption, we may experience periods of reduced ~~instrumentation~~ production. Any unexpected interruptions in our ~~instrumentation~~ production capabilities may lead to delayed or lost sales and may adversely affect our results of operations for the affected period.

In addition, to the extent we temporarily shutdown any facility following such an unforeseen event, we may experience disruptions in our ability to ship products to customers or otherwise operate our business as a result of the unforeseen event. While our global operations give us the ability to ship product from alternative sites, we may not be able to do so because our customers’ facilities are shutdown or the local logistics infrastructure is not functioning, and our sales will suffer.

Damage to our property due to unforeseen events and the disruption of our business from casualties may be covered by insurance, but this insurance may not be sufficient to cover all of our potential losses and such insurance may not continue to be available to us on acceptable terms, or at all. In addition, we may incur incremental costs following an unforeseen event which will reduce profits and adversely affect our results of operations.

~~Risks Related to our Intellectual Property~~

We depend on patents and proprietary rights that may fail to protect our business.

Our success depends to a large extent on our ability to develop proprietary products and technologies and to establish and protect our patent and trademark rights in these products and technologies. As of December 31, ~~2011~~2012, we owned ~~186~~193 issued patents in the United States, ~~136~~143 issued patents in Germany and ~~740~~767 issued patents in other major industrialized countries. In addition, at December 31, ~~2011~~2012, we had ~~1,045~~972 pending patent applications, and we intend to file applications for additional patents as our products and technologies are developed. The patent positions of technology-based companies ~~including our Company,~~ involve complex legal and factual questions and may be uncertain, and the laws governing the scope of patent coverage and the periods of enforceability of patent protection are subject to change. In addition, patent applications in the United States are maintained in secrecy until patents issue, and publication of discoveries in the scientific or patent literature tends to lag behind actual discoveries by several months. Therefore, no assurance can be given that patents will issue from any patent applications that we own or license or if patents do issue, that the claims allowed will be sufficiently broad to protect our technology. In addition, no assurance can be given that any issued patents that we own or license will not be challenged, invalidated or circumvented, or that the rights granted thereunder will provide us competitive advantages. Further, as issued patents expire, we may lose some competitive advantage as others develop competing products and as a result, we may lose revenue.

A significant portion of HPV-related intellectual property is in the public domain, while additional HPV-related intellectual property is subject to our patents some of which will begin to expire in the next few years or are licensed to us on a non-exclusive basis. As a result, other companies have developed or may develop HPV detection tests.

Certain of our products incorporate patents and technologies that are licensed from third parties and for certain products, these in-licensed patents together with other patents provide us with a competitive advantage. These licenses impose various commercialization, sublicensing and other obligations on us. Our failure to comply with these requirements could result in the conversion of the applicable license from being exclusive to non-exclusive or, in some cases, termination of the license, and as a result, we may lose some competitive advantage and experience a loss of revenue.

We also rely on trade secrets and proprietary know-how, which we seek to protect through confidentiality agreements with our employees and consultants. There can be no assurance that any confidentiality agreements that we have with our employees, consultants, outside scientific collaborators and sponsored researchers and other advisors will provide meaningful protection for our trade secrets or adequate remedies in the event of unauthorized use or disclosure of such information. There also can be no assurance that our trade secrets will not otherwise become known or be independently developed by competitors.

We currently engage in, and may continue to engage in, collaborations with academic researchers and institutions. There can be no assurance that under the terms of such collaborations, third parties will not acquire rights in certain inventions developed during the course of these collaborations.

We are subject to risks associated with patent litigation.

The biotechnology industry has been characterized by extensive litigation regarding patents and other intellectual property rights. We are aware that patents have been applied for and/or issued to third parties claiming technologies for the sample and assay technologies that are closely related to those we use. From time to time, we receive inquiries requesting confirmation that we do not infringe patents of third parties. We endeavor to follow developments in this field, and we do not believe that our technologies or products infringe any proprietary rights of third parties. However, there can be no assurance that third parties will not challenge our activities and, if so challenged, that we will prevail. In addition, the patent and

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proprietary rights of others could require that we alter our products or processes, pay licensing fees or cease certain activities, and there can be no assurance that we will be able to license any technologies that we may require on acceptable terms. In

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addition, litigation, including proceedings that may be declared by the U.S. Patent and Trademark Office or the International Trade Commission, may be necessary to respond to any assertions of infringement, enforce our patent rights and/or determine the scope and validity of our proprietary rights or those of third parties. Litigation could involve substantial cost, and there can be no assurance that we would prevail in any proceedings.

~~Risks Related to Product Liability Issues~~

Our business exposes us to potential product liability.

The marketing and sale of our products and services for certain applications entail a potential risk of product liability. Although we are not currently subject to any material product liability claims, product liability claims may be brought against us in the future. Further, there can be no assurance that our products will not be included in unethical, illegal or inappropriate research or applications, which may in turn put us at risk of litigation. We carry product liability insurance coverage, which is limited in scope and ~~amount, but that we believe is currently appropriate for us.~~amount. There can be no assurance ~~however,~~ that we will be able to maintain this insurance at a reasonable cost and on reasonable terms, or that this insurance will be adequate to protect us against any or all potential claims or losses.

We are subject to various laws and regulations generally applicable to businesses in the different jurisdictions in which we operate, including laws and regulations applicable to the handling and disposal of hazardous substances. ~~Although we believe that our procedures for the handling and disposal of hazardous materials comply with the standards prescribed by applicable regulations, the~~The risk of accidental contamination or injury from these materials cannot be completely eliminated. In the event of such an accident, we could be held liable for any damages that result, and any such liability could have a material adverse impact on us.

~~Risks Related to Our Common Shares~~

Our operating results may vary significantly from period to period and this may affect the market price of our Common Shares.

Our operating results may vary significantly from quarter to quarter, and also from year to year, since they are dependent upon a broad range of factors that include demand for our products, the level and timing of customer research budgets and commercialization efforts, the timing of government funding budgets of our customers, the timing of our research and development activities and related regulatory approvals, the impact of sales and marketing expenses, the introduction of new products by us or our competitors, competitive market conditions, exchange rate fluctuations and general economic conditions. Our expense levels are based in part on our expectations as to future sales trends. As a result, sales and earnings may vary significantly from quarter to quarter or from year to year, and actual sales and earnings results in any one period will not necessarily be indicative of results to be anticipated in subsequent periods. Our results may also fail to meet or exceed the expectations of securities analysts or investors, which could cause a decline in the market price of our Common Shares.

Our holding company structure makes us dependent on the operations of our subsidiaries.

QIAGEN N.V. is incorporated under Dutch law as a public limited liability company (naamloze vennootschap), and is organized as a holding company. Currently, the material assets are the outstanding shares of the QIAGEN subsidiaries, intercompany receivables and other financial assets such as cash and short-term investments. As a result, QIAGEN N.V. is dependent upon payments, dividends and distributions from the subsidiaries for funds to pay operating and other expenses as well as to pay future cash dividends or distributions, if any, to holders of our Common Shares. Dividends or distributions by subsidiaries in a currency other than the U.S. dollar may result in a loss upon a subsequent conversion into U.S. dollars.

U.S. civil liabilities may not be enforceable against us.

We are incorporated under Dutch law, and substantial portions of our assets are located outside of the U.S. In addition, certain members of our Managing and Supervisory Boards and our officers reside outside the U.S. As a result, it may be difficult for investors to effect service of process within the U.S. upon us or such other persons, or to enforce outside the U.S. any judgments obtained against such persons in U.S. courts, in any action, including actions predicated upon the civil liability provisions of U.S. securities laws.

In addition, it may be difficult for investors to enforce, in original actions brought in courts in jurisdictions located outside the U.S., rights predicated upon the U.S. securities laws. There is no treaty between the U.S. and the Netherlands for the mutual recognition and enforcement of judgments (other than arbitration awards) in civil and commercial matters. As a result, a final judgment for the payment of money rendered by any federal or state court in the U.S. based on civil liability, whether or

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not predicated solely upon the federal securities laws, would not be directly enforceable in the Netherlands. However, if the party in whose favor such final judgment is rendered brings a new suit in a competent court in the Netherlands, such party may submit to the Dutch court the final judgment which has been rendered in the U.S. If the Dutch court finds that the jurisdiction of the federal or state court in the U.S. has been based on grounds that are internationally acceptable and that proper legal procedures have been observed, the Dutch court will, in principle, give binding effect to the final judgment which has been rendered in the U.S. unless such judgment contravenes Dutch principles of public policy. Based on the foregoing, there can be no assurance that U.S. investors will be able to enforce against us, members of our Managing or Supervisory Boards, or officers who are residents of the Netherlands or countries other than the U.S. any judgments obtained in U.S. courts in civil and commercial matters, including judgments under the federal securities laws. In addition, there is doubt as to whether a Dutch court would impose civil liability on us, the members of our Managing or Supervisory Boards, or our officers in an original

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action predicated solely upon the federal securities laws of the U.S. brought in a court of competent jurisdiction in the Netherlands against us or such members or officers, respectively.

Our Common Shares may have a volatile public trading price.

The market price of our Common Shares since our initial public offering in September 1996 has increased significantly and been highly volatile. In the last two years, the price of our Common Shares has ranged from a high of ~~$24.00~~$22.20 to a low of $12.47 on NASDAQ, and a high of ~~EUR 17.87~~€15.25 to a low of ~~EUR 9.07~~€9.07 on the Frankfurt Stock Exchange. In addition to overall stock market fluctuations, factors that may have a significant impact on the price of our Common Shares include:

announcements of technological innovations or the introduction of new products by us or our competitors;

developments in our relationships with collaborative partners;

quarterly variations in our operating results or those of our peer companies;

changes in government regulations, tax laws or patent laws;

developments in patent or other intellectual property rights;

developments in government spending budgets for life sciences-related research;

general market conditions relating to the diagnostics, applied testing, pharmaceutical and biotechnology industries; and

impact from foreign exchange rates.

The stock market has from time to time experienced extreme price and trading volume fluctuations that have particularly affected the market for technology-based companies. These fluctuations have not necessarily been related to the operating performance of these companies. These broad market fluctuations may adversely affect the market price of our Common Shares.

Holders of our Common Shares should not expect to receive dividend income.

We have not paid cash dividends since our inception and do not anticipate paying any cash dividends on our Common Shares for the foreseeable future. Although we do not anticipate paying any cash dividends, the distribution of any cash dividends in a currency other than the U.S. dollar will be subject to the risk of foreign currency transaction losses. Investors should not invest in our Common Shares if they are seeking dividend income; the only return that may be realized through investing in our Common Shares would be through an appreciation in the share price.

Shareholders who are United States residents could be subject to unfavorable tax treatment.

We may be classified as a “passive foreign investment company,” or a PFIC, for U.S. federal income tax purposes if certain tests are met. Our treatment as a PFIC could result in a reduction in the after-tax return to holders of Common Shares and would likely cause a reduction in the value of these shares. If we were determined to be a PFIC for U.S. federal income tax purposes, highly complex rules would apply to our U.S. shareholders. We would be considered a PFIC with respect to a U.S. shareholder if for any taxable year in which the U.S. shareholder held the Common Shares, either (i) 75% or more of our gross income for the taxable year is passive income; or (ii) the average value of our assets (during the taxable year) which produce or are held for the production of passive income is at least 50% of the average value of all assets for such year. Based on our income, assets and activities, we do not believe that we were a PFIC for U.S. federal income tax purposes for our taxable year ended December 31, ~~2011~~2012, and do not expect to be a PFIC for the current taxable year or any future taxable year. No assurances can be made, however, that the Internal Revenue Service will not challenge this position or that we will not subsequently become a PFIC. In countries outside the U.S., other or similar tax regimes may apply and result in unfavorable tax treatment for any dividends received.

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Future sales and issuances of our Common Shares could adversely affect our stock price.

Any future sale or issuance of a substantial number of our Common Shares in the public market, or any perception that a sale may occur, could adversely affect the market price of our Common Shares. Under Dutch law, a company can issue shares up to its authorized share capital provided for in its Articles of Association. Pursuant to our Articles of Association, our authorized share capital amounts to EUR 9.0 million, which is divided into 410.0 million common shares, 40.0 million financing preference shares and 450.0 million preference shares, with all shares having a EUR 0.01 par value. As of December 31, ~~2011~~2012, a total of approximately ~~234.2~~236.5 million Common Shares were outstanding along with approximately ~~12.2~~12.3 million additional shares reserved for issuance upon exercise or release of outstanding stock options and awards, of which ~~5.5~~4.3 million were vested. A total of approximately ~~22.2~~19.9 million Common Shares are reserved and available for issuances under our stock plans as of December 31, ~~2011~~2012, including the shares subject to outstanding stock options and awards. The majority of our

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outstanding Common Shares are free for sale, except shares held by our affiliates, which are subject to certain limitations on resale. Additionally, holders of notes issued by QIAGEN Finance (Luxembourg) S.A. and QIAGEN Euro Finance (Luxembourg) S.A. are entitled to convert their notes into approximately 26.5 million Common Shares, subject to adjustments in certain cases.

Provisions of our Articles of Association and Dutch law and an option we have granted may make it difficult to replace or remove management and may inhibit or delay a takeover.

Our Articles of Association, or Articles, provide that our shareholders may only suspend or dismiss our Managing Directors and Supervisory Directors against their wishes with a vote of two-thirds of the votes cast if such votes represent more than 50% of our issued share capital. If the proposal was made by the joint meeting of the Supervisory Board and the Managing Board, a simple majority is sufficient. The Articles also provide that if the members of our Supervisory Board and our Managing Board have been nominated by the joint meeting of the Supervisory Board and Managing Board, shareholders may only overrule this nomination with a vote of two-thirds of the votes cast if such votes represent more than 50% of our issued share capital.

Certain other provisions of our Articles allow us, under certain circumstances, to prevent a third party from obtaining a majority of the voting control of our Common Shares through the issuance of Preference Shares. Pursuant to our Articles and the resolution adopted by our General Meeting of Shareholders, ~~on October 11, 2007,~~ our Supervisory Board is entitled to issue Preference Shares in case of an intended takeover of our company by (i) any person who alone or with one or more other persons, directly or indirectly, have acquired or given notice of an intent to acquire (beneficial) ownership of an equity stake which in aggregate equals 20% or more of our share capital then outstanding or (ii) an “adverse person” as determined by the Supervisory Board. If the Supervisory Board opposes an intended takeover and authorizes the issuance of Preference Shares, the bidder may withdraw its bid or enter into negotiations with the Managing Board and/or Supervisory Board and agree on a higher bid price for our Shares.

In 2004, we granted an option to the Stichting Preferente Aandelen QIAGEN, or the Foundation (Stichting), subject to the conditions described in the paragraph above, which allows the Foundation to acquire Preference Shares from us. The option enables the Foundation to acquire such number of Preference Shares as equals the number of our outstanding Common Shares at the time of the relevant exercise of the option, less one Preference Share. When exercising the option and exercising its voting rights on these Preference Shares, the Foundation must act in our interest and the interests of our stakeholders. The purpose of the Foundation option is to prevent or delay a change of control that would not be in the best interests of us and our stakeholders. An important restriction on the Foundation’s ability to prevent or delay a change of control is that a public offer must be announced by a third party before it can issue (preference or other) protective shares that would enable the Foundation to exercise rights to 30% or more of the voting rights without an obligation to make a mandatory offer for all shares held by the remaining shareholders. In addition, the holding period for these shares by the Foundation is restricted to two years, and this protective stake must fall below the 30% voting rights threshold before the two-year period ends.

Note Regarding Forward-Looking Statements and Risk Factors

Our future operating results may be affected by various risk factors, many of which are beyond our control. Certain statements included in this Annual Report and the documents incorporated herein by reference may be forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended, including statements regarding potential future net sales, gross profit, net income and liquidity. These statements can be identified by the use of forward-looking terminology such as “believe,” “hope,” “plan,” “intend,” “seek,” “may,” “will,” “could,” “should,” “would,” “expect,” “anticipate,” “estimate,” “continue” or other similar words. Reference is made in particular to the description of our plans and objectives for future operations, assumptions underlying such plans and objectives, and other forward-looking statements. Such statements are based on management’s current expectations and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. We caution investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors. Factors which could cause such results to differ materially from those described in the forward-looking statements include those set forth in the risk factors below. As a result, our future success involves a high degree of risk. When considering forward-looking statements, you should keep in mind that the risk factors could cause our actual results to differ significantly from those contained in any forward-looking statement.

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Item 4.	Information on the Company

Description of our business

Company overview

QIAGEN is the world's leading provider of innovative Sample & Assay ~~Technologies. Our~~Technologies, based on independent market studies of United States and European market shares for our products and technologies. Our automated systems ~~are playing a pivotal role in the biology revolution by empowering~~and consumable products empower customers to transform raw biological samples into valuable molecular information. ~~QIAGEN~~Sample technologies ~~allow healthcare providers~~are used to ~~detect disease~~isolate DNA (deoxyribonucleic acid), RNA (ribonucleic acid) and ~~make treatment decisions, scientists~~proteins from any biological sample, such as blood or tissue. Assay technologies are then used to ~~explore~~amplify, enrich and provide results for analysis of biomolecules, such as the ~~secrets~~DNA of ~~life, pharmaceutical companies to develop new drugs, and other professionals to apply advanced tools for~~ a ~~diverse range~~virus or a mutation of ~~needs that include human identification, veterinary medicine and food safety.~~ a gene.

Our mission is to make improvements in life possible by enabling our customers to achieve outstanding success and breakthroughs in Molecular

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Diagnostics, Applied Testing, Pharma and Academia.

Biological samples contain millions of molecules, but only a small portion of this material is typically of interest for specific medical or other applications. Sample technologies are used to collect biological materials and stabilize, extract and purify the molecule of interest. Assay technologies are then used to amplify and enrich this small amount of isolated material to make it readable and ready for interpretation. Sample & Assay Technologies operate in a highly synchronized manner.

QIAGEN began operations in 1986 by introducing to the emerging biotechnology sector a novel method that standardized and dramatically accelerated the extraction and purification of nucleic acids-biological molecules such as DNA ~~(deoxyribonucleic acid)~~ and RNA ~~(ribonucleic acid)~~ that are essential for life as carriers of genetic information. Since the introduction of that first ready-to-use kit, QIAGEN has expanded to become the global leader with a broad offering of molecular technologies, including related automated systems.

Our products are used in virtually all areas of science focused on advancing knowledge about the molecular basis of life. QIAGEN has become a trusted partner by enabling ~~researchers~~customers to obtain exciting insights with products that are considered standards for quality and reliability. More than one billion biological samples are estimated to already have been prepared or analyzed using QIAGEN technologies in laboratories around the world. Net sales of ~~$1.2~~$1.25 billion in ~~2011~~2012 were composed of consumable kits and other revenues (87% of sales) and automated systems and instruments (13% of sales).

QIAGEN has leveraged its leadership position in Sample & Assay Technologies to build a strong global position in Molecular ~~Diagnostics.~~Diagnostics, now our largest customer class, accounting for 49% of net sales in 2012. The commercial applications of molecular technologies are transforming healthcare by providing highly specific genetic information to guide prevention and treatment strategies. Molecular Diagnostics accounted for 47% of net sales in 2011. Our products also are increasingly used in Applied Testing, which are areas of molecular testing not related to human healthcare or research that include human identification and forensics, food and water safety, and veterinary testing.

With a focus on innovation, QIAGEN ~~now~~ markets more than 500 core products that are distributed in thousands of variations and combinations. Innovative products are continually being introduced to address new market opportunities or extend the life of existing product lines. We have made a number of strategic acquisitions to enhance our technology and product offerings. We have funded our growth through internally generated funds as well as through debt offerings and private and public sales of equity securities. QIAGEN shares are listed on the NASDAQ exchange under the ticker symbol “QGEN” and on the Frankfurt Prime Standard as “QIA.”

The company is registered under its commercial and legal name QIAGEN N.V. with the trade register (kamer van koophandel) of the Dutch region Limburg Noord under file number 12036979. QIAGEN N.V. is a public limited liability company (naamloze vennootschap) under Dutch law as a holding company. Our principal executive office is located at Spoorstraat 50, 5911 KJ Venlo, The Netherlands, and our telephone number is +31-77-320-8400.

As a holding company, QIAGEN conducts business through subsidiaries located throughout the ~~world, including the Americas, Europe, China, Japan, Australia, India and other major markets.~~world. Further information about QIAGEN can be found at www.qiagen.com. By referring to our website, we do not incorporate the website or any portion of the website by reference into this Annual Report.

Recent Developments

QIAGEN achieved a number of recent strategic milestones in the development of our ~~business in 2011:~~business:

In January, QIAGEN began direct sales through a subsidiary in India, a strategic market with 1.2 billion people and rapidly growing healthcare and R&D sectors. The new presence in India is a milestone in QIAGEN's strategy to expand our footprint in emerging, high-growth regions.

In May, we updated our strategy for ongoing development of the QIAensemble suite of next-generation automation platforms, including the QIAensemble Decapper, the industry's first automated device to unseal liquid cytology sample vials, one of the most burdensome steps in laboratory workflow. The Decapper was launched in December 2011. The future QIAensemble suite is planned to incorporate proven core components from the QIAsymphony platform, enhancing compatibility and allowing migration of tests between the two platforms.

In July, QIAGEN purchased 62% of the shares of Ipsogen S.A., a publicly listed French company that is a global leader in molecular profiling for leukemia and other blood cancers. We initiated a public tender offer for the remaining shares in October and held an 89% stake by year-end. QIAGEN intends to fully acquire Ipsogen. The relationship provides access to a broad range of assays covering 15 biomarkers used worldwide for the diagnosis, prognosis and monitoring of patients with various blood cancers. Many of these assays have the potential to be used as companion diagnostics to guide treatment decisions. Almost all of Ipsogen's assays have been developed for use on QIAGEN's

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~~Rotor-Gene Q real-time PCR system, which will enable smooth transfer onto the QIAsymphony RGQ platform.~~

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In ~~August,~~May 2012, we ~~fully~~ acquired ~~Cellestis Ltd., a publicly listed Australian company that has developed and begun to commercialize QuantiFERON~~AmniSure International LLC, including the AmniSure^® assay for determining whether a pregnant woman is suffering rupture of fetal membranes (ROM), a ~~patent-protected “pre-molecular” technology capable~~widespread cause of ~~providing information on diseases far earlier than possible with~~premature delivery and neonatal complications. This product, approved in the U.S. and many other ~~diagnostic methods. Cellestis~~markets, is expected to be catalytic for our Point of Need portfolio and beneficial to our presence in women's health. AmniSure provided a new growth driver for QIAGEN in 2012 as we integrated this Point of Need product into our commercial operations.

In June 2012, we unveiled an initiative to enter the next-generation sequencing (NGS) market by creating an innovative sample-to-result NGS workflow designed to enable the routine use of this breakthrough technology in areas such as clinical research and molecular diagnostics. Adoption of NGS beyond life science research has been hampered by workflow challenges related in part to the larger number of samples processed in clinical settings.

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Our highly automated NGS offering will integrate a range of QIAGEN consumable and automation solutions, as well as components accessed through partnerships or acquired, including our acquisition of Intelligent Bio-Systems, Inc. in early 2012. Development of our unique GeneReader NGS benchtop sequencer, addressing many challenges for customers in clinical research and diagnostics, is on track. In late 2012 and early 2013, QIAGEN has launched 15 NGS products, all “universal” or compatible with any NGS platform, to enhance pre-analytical sample preparation, DNA library preparation and detection of targeted cancer genes. We plan to begin placing QIAGEN NGS workflows with selected customer groups during 2013.

•

A landmark addition of test content was achieved in July 2012 when we received U.S. regulatory ~~approvals and product launches in major markets~~approval for ~~QuantiFERON~~our therascreen^®~~-TB Gold In-Tube,~~ KRAS RGQ PCR Kit, which provides guidance on the use of Erbitux^® (cetuximab) as a ~~leading test for latent tuberculosis (TB), a non-symptomatic infection that affects~~treatment in patients with metastatic colorectal cancer. Leading U.S. laboratories covering approximately ~~one-third~~half of the ~~world's population. We believe QuantiFERON-TB Gold has significant untapped market potential as~~current KRAS testing volumes in the U.S. adopted the therascreen^® KRAS test by year end. The first therascreen^®companion diagnostic approved by the Food and Drug Administration (FDA) marked a ~~preventive screening test~~milestone in global expansion of our Personalized Healthcare franchise, building on success in Europe and Japan, where we offer a range of companion diagnostics. In January 2012, for example, our therascreen^® EGFR Mutation Detection Kit RGQ was approved in Japan to ~~protect vulnerable populations from development~~guide treatment of ~~active TB disease.~~cancers targeted by certain anticancer drugs. In late 2012, the therascreen^® EGFR RGQ PCR Kit was submitted to the FDA to guide treatment with afatinib, an investigational oncology compound developed by Boehringer Ingelheim that was granted FDA priority review status in January 2013.

In August, QIAGEN began direct sales in Taiwan, a rapidly growing, dynamic market that adds momentum to our expansion in Asia, especially in serving the active academic research and pharmaceutical drug development sectors in Taiwan.

•

Our QIAsymphony platform achieved several milestones as placements exceeded the target of 750 by year-end 2012. In July 2012, one of the modules in the QIAsymphony family, the Rotor-Gene Q MDx real-time PCR cycler, received U.S. regulatory approval for use with our KRAS companion diagnostic kit, following approval earlier in the year to run our influenza A/B test kits. Also in July, the QIAsymphony RGQ platform received validation from an independent food safety group, the AOAC Research Institute, to run our mericon^® Salmonella spp. kit in an automated workflow from food sample to final result. In 2012, China's State Food and Drug Administration (SFDA) approved QIAsymphony SP for automated sample preparation and QIAsymphony AS for assay setup workflows. With the 2010 SFDA clearance of the Rotor-Gene Q real-time PCR thermocycler, QIAGEN now offers customers in China the full QIAsymphony RGQ modular system.

Also in August, we entered into a partnership with Pfizer Inc. for development of a companion diagnostic based on QIAGEN's proprietary KRAS assay technology, which reliably detects mutations of the KRAS gene, for use in guiding treatment with an investigational Pfizer compound in global clinical development for non-small cell lung cancer (NSCLC).

In September 2012, our emerging Point of Need franchise reached a milestone with the first regulatory approval in healthcare for the ESEQuant Lateral Flow System, a portable platform that QIAGEN ~~entered into~~acquired in 2010 and is developing for multiple applications. Under an agreement with Lepu Medical Technology (Beijing) Co., Ltd., a ~~partnership~~leading medical device company in China, the ESEQuant instrument will be deployed in emergency rooms to provide rapid results from Lepu's tests for cardiac markers - diagnosing acute myocardial infarction (heart attack) without sending samples out to a laboratory.

In October 2012, we announced a collaboration with Bayer HealthCare for development and commercialization of companion diagnostics paired with novel Bayer drugs, initially to enhance the treatment of various solid tumors. The assays under development will be designed to run on our QIAsymphony family of automated instruments. In addition to the Bayer collaboration, we have a significant number of projects under way to co-develop and market companion diagnostics with leading pharmaceutical and biotech companies.

In November 2012, we announced China's SFDA approved QIAGEN's careHPV Test and instrument platform, the first molecular diagnostic for human papillomavirus, or HPV, designed for low-resource clinical settings, such as areas lacking electricity, water or modern laboratories. Following product availability for careHPV in China in January 2013, we expect to introduce it in India and other emerging markets as approvals are received. In March 2012, we expanded access to our digene HPV Test across China through a co-marketing agreement with KingMed Diagnostics, China's largest independent laboratory network. The digene HPV Test was first registered in China in 2000 and is widely available in many of the country's top-tier hospitals and private labs. The KingMed agreement extends access to smaller hospitals, with KingMed functioning as a centralized laboratory.

In January 2013, we announced three agreements to add biomarkers to our development pipeline for new companion diagnostics to guide treatment decisions in diseases such as rheumatoid arthritis, lung cancer and colorectal cancer. Most of the assays will be designed to run on the QIAsymphony RGQ automation system, as well as our NGS workflow currently in development.

In February 2013, we announced a master collaboration agreement with Eli Lilly and Company for the development ~~manufacturing~~ and commercialization of companion diagnostics for pairing with Lilly investigational and approved

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medicines across all therapeutic areas. The agreement creates a ~~companion diagnostic~~framework for ~~an early stage investigational compound known as a Janus kinase 2 (JAK2) inhibitor.~~expanding QIAGEN and Lilly's ~~proposed drug targets the JAK2 gene, which has been shown~~existing collaboration to ~~play a role in myeloproliferative neoplasms, a variety~~development of ~~blood cancers. We gained exclusive access to the JAK2 biomarker being used in developing the companion diagnostic through our agreement with Ipsogen.~~

In November, QIAGEN began implementing a project to enhance productivity and free up resources for reallocation to strategic initiatives to drive growth and innovation. Initial actions focused on eliminating organizational layers, overlapping structures and duplication between global, regional and local activities. As part of this project, R&D activities will focus more tightly on high-growth areas in all customer classes. QIAGEN also plans to optimize capacity utilization at selected sites and capture savings from shared service functions. As part of this project, QIAGEN reduced its worldwide workforce by approximately 8-10% at the end of 2011 and in early 2012. Annual pre-tax cost savings of approximately $50 million are expected in 2012, with the majority to be reinvested in strategic initiatives.additional potential products.

Our Products

QIAGEN holds leadership positions in a wide range of customer classes for Sample & Assay Technologies. We offer more than 500 core consumable products (known as “kits”) as well as a number of instrument solutions to fully automate the processing of almost all QIAGEN products used for sample preparation and subsequent analysis. The terms “Sample” and “Assay” Technologies define two phases of the process of unlocking valuable molecular information from raw biological materials, predominantly in digital form:

Sample Technologies: QIAGEN has developed and advanced a broad range of technologies to extract and purify molecules of interest from biological samples such as blood, bone, tissue, etc. QIAGEN technologies ensure that a biological sample is consistently processed in a highly reproducible, standardized method with the highest level of quality before entering subsequent analysis with assay technologies.

Assay Technologies: Building on its leadership in sample technologies, QIAGEN has developed assay technologies that enable the analysis of various kinds of molecules from virtually any biological sample. Assay technologies make information contained in isolated molecules visible and available for interpretation. Assays are tailor-made to address the specific demands of various research areas and commercial applications. ~~Laboratory Developed~~Laboratory-Developed Test (LDT) assays enable the customer to target molecules of interest for detection using reagents in the kit on platforms such as polymerase chain reaction (PCR). Commercially approved assays are preconfigured by QIAGEN to test for specific targets such as genetic mutations, gene expression levels, influenza, human papillomavirus (HPV), tuberculosis (TB), hepatitis and herpes viruses, or human immunodeficiency virus (HIV).

These technologies provide two main categories of revenue streams for QIAGEN:

Revenues from consumables and related sales:

Consumable products, typically sample preparation or test kits and related sales, account for approximately 85-90% of our net sales. To maximize customer convenience and reduce user error, these kits contain all necessary reagents and buffers, and a manual including protocols and relevant background information. Each kit is sufficient to support a number of applications, varying from one to more than 1,000 tests.

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Major applications for QIAGEN consumable products are plasmid DNA purification, RNA purification and stabilization; genomic and viral nucleic acid purification; nucleic acid transfection; ~~polymerase chain reaction (PCR)~~PCR amplification; reverse transcription; DNA cleanup after PCR and sequencing; DNA cloning and protein purification. Our validated PCR assays enable detection of viral or bacterial pathogens and parasites in humans and animals, as well as pharmacogenomic testing and genotyping.

Our largest-selling product is the digene HC2 HPV Test, a signal-amplified test regarded as the “gold standard” in testing for high-risk strains of ~~the human papillomavirus (HPV),~~HPV, the primary cause of cervical cancer in women.

Related revenues include royalties, milestone payments from co-development agreements with pharmaceutical companies for companion diagnostics, payments from technology licenses and patent sales. We also have revenue from custom services, such as whole genome amplification services, DNA sequencing, and non-cGMP DNA production on a contract basis.

Automation ~~systems~~platforms and instruments:

Our instrumentation systems automate the use of Sample & Assay Technologies into efficient solutions for a broad range of laboratory needs. These ~~systems,~~platforms, which account for approximately ~~10% to 15%~~10-15% of net sales, enable customers to perform reliable and reproducible nucleic acid sample preparation, assay setup, target detection and other laboratory tasks.

QIAGEN offers automated ~~systems~~platforms for all phases of testing, from sample to result. Among them:

~~QIAsymphony~~ ~~is an innovative, easy-to-use modular system offering~~

QIAsymphony is an innovative, easy-to-use modular system that is making laboratory workflows more efficient and helping to disseminate standardized, regulator-approved diagnostics. The platform offers many features of interest to laboratories, such as continuous loading, random access, and the ability to process an almost unlimited range of sample types. QIAsymphony received the Association for Laboratory Automation's New Product Award (NPA) following its introduction in 2008. In late 2010, we launched

Table of ~~sample types. QIAsymphony received the Association for Laboratory Automation's New Product Award (NPA) following its introduction in 2008. In late 2010, we launched~~ Contents

QIAsymphony RGQ, an integrated system that has started a new era of integrated workflow consolidation and laboratory automation, covering all steps from initial sample processing to ~~the~~ final result. QIAsymphony RGQ gives customers access to a broad menu of commercially available assays while also allowing them to run their own PCR-based ~~laboratory-developed tests (LDTs),~~LDTs, which account for more than half of the volume of tests performed in many molecular diagnostic laboratories. In ~~2011,~~2012, the installed base of QIAsymphony systems increased to more than 750 instruments worldwide, up from more than 550 ~~instruments worldwide.~~at year-end 2011.


	Rotor-Gene Q, the world's first rotary real-time PCR cycler system, uses real-time PCR reactions to make specific sequences of DNA and RNA visible through amplification and quantifiable through real-time measurement. This system enhances QIAGEN's options to offer sample and assay technology solutions spanning from sample to result, and is an integral part of the QIAsymphony RGQ system.

QIAensemble is a mid- to high-throughput automation platform for rapid turnaround of higher volumes of tests used for preventive screening, particularly for pathogens such as HPV. QIAGEN is developing automation upgrades to QIAensemble based on the current Rapid Capture System, as well as next-generation capabilities and expanded test menus. In late 2011 we launched QIAensemble Decapper, the first instrument to automate the handling of liquid-based cytology and other liquid samples in clinical laboratories - saving money and time by eliminating a series of tedious steps.

PyroMark is a high-resolution detection platform based upon Pyrosequencing technology that allows for the real-time analysis and quantification of genetic mutations and DNA methylation patterns down to the single base pair level. This enables users to identify even previously unknown mutations or variations in targeted DNA regions. This technology also can be employed in multiplex analysis for genetic and pathogen detection. Pyrosequencing plays a pivotal role in epigenetic research and also can be of great value to diagnostic laboratories running personalized healthcare and profiling assays.


	QIAcube, a sample processing instrument incorporating novel and proprietary technologies, allows users to fully automate the use of almost all of our products originally designed for manual processing of samples. The QIAcube received the NPA honor ~~from the Association for Laboratory Automation~~ in 2007.


	QIAxcel, designed to take the place of traditional slab-gel analysis, can replace tedious and time-consuming methods of nucleic acid separation in low- to high-throughput laboratories. QIAxcel is characterized by unprecedented sensitivity and time to results for analysis of DNA fragments and RNA.

ESE-Quant Tube Scanners are portable, battery-operated optical measurement devices based on technology developed by ESE GmbH, a company we acquired in 2010. These UV and fluorescence detection systems enable point of need testing in healthcare and applied testing markets. The ESE technology permits low-throughput molecular testing in physician practices, emergency rooms, remote field areas, and other settings where a laboratory infrastructure is not accessible and fast turnaround is required.

Customers

From the early days of the biotechnology revolution, we believed that Sample & Assay Technologies for nucleic acids would play an increasingly important role in cutting-edge biology-and that major new commercial uses would develop for information extracted from DNA and RNA. WeSince 1986, we have been supplying customers ~~since 1986~~ with innovative proprietary

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products for the analysis of nucleic acids.

We sell our products, sample and assay kits known as consumables and automated instrumentation platforms using those technologies, to four major customer classes:

~~We focus on four customer classes for our products:~~

Molecular Diagnostics~~-enabling hospitals, physicians~~-healthcare providers supporting many aspects of patient care including prevention, profiling of diseases, personalized healthcare and ~~other providers to save lives and fight disease. The commercial use~~point of ~~these technologies in human healthcare has grown to provide approximately half of QIAGEN net sales.~~need testing

Applied Testing~~-unlocking the potential of~~-government or industry customers using molecular ~~information~~technologies in ~~testing~~ fields ~~not related to human healthcare,~~ such as forensics, veterinary diagnostics and food safety testing

Pharma-drug discovery, translational medicine and ~~water testing, veterinary medicine, environmental testing and biosecurity.~~

~~Pharma-supporting gene-based drug discovery and~~clinical development byefforts of pharmaceutical and biotechnology companies ~~as well as the manufacturing and quality control of biological medicines.~~

Academia~~-providing tools for~~-researchers exploring the secrets of life ~~sciences research, including academic institutions and governmental laboratories,~~ such as the ~~National Institutes~~mechanisms and pathways of ~~Health (NIH)~~diseases, and in ~~the U.S. and major research-based universities and institutes around the world.~~some cases translating that research into drug targets or commercial applications

Molecular Diagnostics

The ability of advanced diagnostic technologies to unlock molecular information from patients is changing the practice of medicine, while creating a significant and growing market for nucleic acid sample preparation and assay technology products. In recent years, the advent of ~~polymerase chain reaction (PCR)~~PCR and other amplification technologies has ~~made the prospect of~~brought nucleic acid-based diagnostics ~~feasible.~~into routine

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use in healthcare around the world.

This new generation of molecular diagnostics can be used to identify microorganisms, cancer cells, bacteria and viruses by searching for their specific nucleic acid ~~sequences-or~~sequences or to characterize previously unknown DNA sequences related to human diseases. Commercial applications for molecular diagnostics are multiplying as researchers identify new biological markers for disease and develop novel technologies for detection and analysis of those diagnostic clues from the human body.

The molecular diagnostics market, with sales estimated by industry experts at approximately $3$5 billion in ~~2011~~2013 is still a small part of the global in vitro diagnostics market, but it is the fastest growing segment at a projected compound annual growth rate of ~~approximately~~ 10%. or more. Market penetration is still low in the U.S., other developed countries and emerging markets. However, given the advantages of precise genetic information over traditional tests, QIAGEN expects the molecular diagnostics market to provide significant growth opportunities over the long term.

Growth in the Molecular Diagnostics customer class is built upon four strategies for fighting disease, and QIAGEN is targeting each of these fields with a range of dedicated products and tailored marketing:

Prevention-using advanced technologies to screen non-symptomatic patients as a preventive strategy, such as testing women for HPV to protect from cervical cancer or screening patients for latent ~~tuberculosis (TB)~~TB infection to guard against active TB disease.

Profiling-screening symptomatic patients to profile the precise type of disease, for example testing patients with flu-like symptoms to confirm or rule out dangerous strains such as the influenza type A (H1N1) swine flu.

Personalized Healthcare-determining which patients are most likely to respond positively to particular therapies, such as landmark QIAGEN tests for testing the mutation status of genes such as KRAS, EGFR, BRAF and others that influence the effectiveness and safety profile of novel medicines for treatment of various cancers.

Point of Need-enabling on-site diagnosis in physician practices, emergency rooms, remote field areas, and other settings where a laboratory infrastructure is not accessible and fast turnaround is required.

We offer one of the broadest portfolios of molecular technologies for human healthcare. Success in Molecular Diagnostics depends on the ability to analyze purified nucleic acid samples from a variety of ~~samples,~~sources, including blood, tissue, body fluids and stool, ~~and~~ on automated systems that can handle hundreds of samples concurrently. Other key factors are the range of assays targeting various diseases and biomarkers, convenience and ease of laboratory workflow, versatility, reliability and standardization of the nucleic acid processing and detection procedures.

One of the largest prevention markets is screening for HPV, a viral infection that is the primary cause of cervical cancer, which kills about 270,000 women a ~~year.~~year worldwide. We are the global ~~market~~ leader in HPV screening ~~technologies.~~technologies, with our market-leading “gold standard” digene HC2 HPV Test and our emerging careHPV Test for use in low-resource regions of the world. In the United States, we sell our HPV products primarily for two FDA-approved indications: adjunctive primary screening with a Pap test for women age 30 and older, and follow-up testing of inconsistent Pap test results in women of any age. In Europe and the rest of the world, HPV testing is in varying stages of adoption. We are working closely with public health authorities and researchers on an increasing number of clinical trials and policy initiatives aimed at expanding the use of HPV testing for prevention or follow-up to treatment of cervical cancer.

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~~Following QIAGEN's 2011 acquisition of Cellestis Ltd., with its~~The early-warning QuantiFERON^®-TB Gold ~~product to detect~~test, which detects latent TB infection ~~we expect to drive the growth of this highly accurate screening test~~ as a strategy for the prevention of ~~active~~ TB disease in vulnerable ~~populations.~~

populations, has become an important growth driver following QIAGEN's 2011 acquisition of the product with its developer, the Australian firm Cellestis Ltd. Approximately one-third of the world's population is infected with the tuberculosis bacterium but suffers no symptoms, a condition known as latent TB. However, about 5% to 10% of those patients at some point will develop active tuberculosis, a potentially life-threatening contagious disease that typical spreads from one active patient to 10 to 20 other people. ~~Sales of QuantiFERON~~^®~~-TB Gold were approximately $55 million in 2011, and the~~The potential global market for latent TB detection is estimated at up to $1 billion.

In Profiling, we offer an extensive range of Sample & Assay Technologies for use in the diagnosis of patients for various infectious diseases, including HIV, hepatitis and influenza. We are expanding this portfolio of assays and ~~intends~~intend to gain regulatory approvals for these products in various geographic regions in the coming ~~years, particularly~~years. In 2012, our assay for detection of Influenza A/B, the ~~U.S.~~artus Infl A/B RG RT-PCR Kit, was approved by the FDA, to run on the Rotor-Gene Q MDx platform. A key element of ~~this~~our global content expansion will be the use of these assay technologies on QIAsymphony RGQ.

In Personalized Healthcare, we ~~enter into collaborative arrangements~~offer companion diagnostics to guide the selection of medicines in treating cancer and other diseases based on a broad portfolio of more than 30 biomarkers. In July 2012, QIAGEN achieved a milestone in Personalized Healthcare with FDA approval of the therascreen^® KRAS RGQ PCR Kit for use in patients with metastatic colorectal cancer. The U.S. rollout of therascreen KRAS builds on a strong global leadership position including Japan, where

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regulators approved the therascreen KRAS and EGFR kits in 2011, and Europe, where QIAGEN offers 10 CE-marked assays for personalized healthcare applications. QIAGEN has more than 15 projects under way to co-develop and market companion diagnostics with leading pharmaceutical and ~~biotech companies for the co-development of companion diagnostics for personalized healthcare.~~biotechnology companies. We have ~~research~~collaborative projects with high-profile companies such as Amgen, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb/ImClone, Eli Lilly, Pfizer and ~~Pfizer. Acquisitions~~Sanofi. Ongoing acquisitions of biomarkers and other technologies contribute to our expanding co-development relationships. For example, shortly after our acquisition of a majority interest in Ipsogen in 2011, we entered an agreement with Eli Lilly to co-develop a companion diagnostic for a Lilly compound for certain blood cancers targeting the Janus kinase 2 (JAK2) gene, based on our exclusive access to the JAK2 biomarker through Ipsogen. The first companion diagnostics are already being marketed in Europe and other markets, and we made regulatory submissions in 2011 for two companion diagnostics to be used with colorectal cancer drugs in the U.S. A key element of the global expansion in ~~this area~~Personalized Healthcare is the ability of labs to efficiently use these assay technologies on QIAsymphony RGQ.

We market a range of automation systems designed for low-, medium-, and high-throughput nucleic acid sample preparation and handling tasks in laboratories performing molecular diagnostics. The flagship platform is QIAsymphony, based on its unique characteristics. Nucleic acid samples purified on our instruments are ready for use in the demanding and sensitive downstream assays performed in molecular diagnostic applications. We offer closed and open assay technologies. Open assay technologies contain PCR reagents to identify molecules of choice. Closed assays, diagnostics with predefined targets, include multiplexing and other pathogen or genetic mutation detection assays such as tests for HIV, tuberculosis, influenza or hepatitis. We market assays directly to end customers via our sales channels, and selected assays through major diagnostic partners with complementary customer groups. In addition, we intend to enter into partnerships or other agreements with companies to broaden the distribution of our products.

Applied Testing

~~Demand~~

Use of molecular technologies is growing in more and more areas of life as industry and government organizations apply standardized sample preparation and assay solutions to diverse needs. Applied ~~Testing-our~~Testing is our term for ~~the use of molecular technologies~~applications outside of human healthcare and research ~~applications. Industry and government organizations use standardized sample preparation and assay solutions for~~- such as human identification and forensics, food and water safety, and veterinary testing. The value of genetic “fingerprinting” has been shown infor criminal investigations ~~involving DNA analysis,~~or clarification of paternity or ancestry, public policy compliance for food safety and genetically modified organisms (GMOs), and containment of diseases in commercial livestock. Molecular testing can be performed by well-trained researchers in fully equipped laboratories, and increasingly also by less-trained personnel provided with easy-to-use, reproducible and standardized methods for point of need testing. Our manual DNA and RNA purification methods and the automated solutions on QIAsymphony, QIAcube, EZ1 Advanced, BioRobot EZ1 and other products, as well as our amplification enzymes and quantitative assays, address the needs in these markets.

Pharma

QIAGEN is a significant supplier for pharmaceutical and biotechnology companies. Drug discovery and ~~development~~translational research efforts increasingly employ genomic information, both to guide research in diseases and to differentiate the patient populations most likely to respond to particular ~~therapies. Approximately~~therapies in clinical settings. We estimate that about half of QIAGEN sales in this customer class support research, while the remaining half of sales support clinical development processes, including the stratification of patient populations based on genetic information. QIAGEN's GeneGlobe online portal (www.geneglobe.com) offers scientists an industry-leading source of information with searchable data on 60,000 genomic technologies for disease pathways, including annotations and references, to guide research and to enable ordering from this ~~very~~ broad portfolio of assays.

As new drugs are commercialized, testing technologies developed in parallel with those therapies can move from Pharma

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R&D into the ~~molecular diagnostics~~healthcare market as companion diagnostics, which ~~would be~~are marketed ~~within the~~in our Molecular Diagnostics customer class. Healthcare professionals ~~then can~~use companion diagnostics to customize treatment by testing for specific genetic biomarkers that help to determine the safety and efficacy profiles of drugs in individual patients, achieving the best possible therapeutic results and avoiding unnecessary treatments. In the coming years, we expect a wave of newly discovered biomarkers and companion diagnostics to transform the treatment of an increasing number of diseases.

In addition to the broad portfolio of molecular technologies, QIAGEN brings to the Pharma market a full infrastructure for co-development programs, intellectual property on platforms and content, extensive regulatory experience, global reach in our sales channels, and independence as a company focusing exclusively on these types of technologies.

Academia

QIAGEN provides Sample & Assay Technologies to leading research institutions around the world. Many academic laboratories continue to utilize manual, labor intensive methods for nucleic acid separation and purification. Recognizing the opportunity to replace traditional methods with reliable, fast, highly reproducible, and high-quality nucleic acid extraction and purification technologies, QIAGEN has concentrated product development and marketing efforts on the research markets in industry and Academia.

~~The~~

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As academic institutions increasingly embrace translational research, bridging from discoveries to practical applications in medicine, the academic market also supports our presence in the Molecular Diagnostics and Pharma customer classes. Research in university settings often helps in the development of specific technologies for targeted biomolecules, and academic research also can result in scientific publications that validate the usefulness of QIAGEN technologies for specific applications.

Global Presence by Geographic Market

QIAGEN currently markets products in more than 100 countries. The following table shows total revenue by geographic market for the past three years (net sales are attributed to countries based on the location of the subsidiary making the sale, as certain subsidiaries have international distribution):


(in thousands)	2011		2010		2009		2012		2011		2010
Net Sales
Americas:
United States	$	466,502	$	472,682	$	446,151	$	518,130	$	466,502	$	472,682
Other Americas	55,137		50,912		47,995		42,921		55,137		50,912
Total Americas	521,639		523,594		494,146		561,051		521,639		523,594
Europe	444,441		398,029		363,949		459,321		444,441		398,029
Asia Pacific and Rest of World	203,667		165,808		151,730		234,084		203,667		165,808
Total	$	1,169,747	$	1,087,431	$	1,009,825	$	1,254,456	$	1,169,747	$	1,087,431

Expansion into high-potential geographic markets is a core priority. ~~The~~Our top seven emerging markets (Brazil, Russia, India, China, South Korea, Mexico and Turkey) represented ~~12%~~more than 10% of net sales in ~~2011.~~2012. We have built a presence in China with approximately 350 employees, ~~making it~~which represents our third-largest geographic market in terms of sales. In 2012, we added subsidiaries in Russia and Poland. In 2011, new subsidiaries were created in India and Taiwan, further expanding our presence in Asia.

~~See Note 21 to our consolidated financial statements included in “Item 18. Financial Statements” for additional information on operations by geographic region.~~

Strategic Initiatives

~~QIAGEN believes~~We believe the relevant global market for molecular diagnostics and life science research products totals approximately $70 billion. Among the fundamental growth drivers in the ~~current~~ business environment are ongoing breakthroughs and insights into molecular biology, new technologies to analyze molecular information, improvements in the quality of healthcare and reductions in cost ~~of healthcare~~ using diagnostics, increasing demands for quality, and revenue streams made possible through consumable products.

We have grown substantially in recent years with a flexible strategy that includes developing innovative new products, partnering, and acquiring companies or technologies to complement our portfolio.

QIAGEN ~~has established these~~is pursuing four strategic ~~initiatives:~~initiatives that aim to:

Drive platform success. We develop innovative instruments that enable our customers to efficiently perform molecular testing in a wide range of applications. Expanding the installed base of our instruments, particularly the QIAsymphony automation platform, also leads to growing sales of our consumable test kits.

Add content. We continually bring new tests to market across all customer classes, meeting urgent market needs in the diagnosis of disease, life science research and other applications. In molecular diagnostics we focus on standardized tests approved by regulatory agencies for routine use in healthcare. Expanding the menu of tests available for efficient workflow on our instruments also enhances the value of our platforms to laboratories.

Broaden geographic presence. We systematically establish and expand our presence in attractive markets around the world, especially high-growth emerging markets. We help developing countries bring state-of-the-art capabilities into their healthcare and research infrastructures. We also develop molecular technologies to meet specific needs in medicine or other applications for emerging markets such as China.

Grow efficiently and effectively. We pursue sustained growth and improved profitability through operational improvements and a culture that encourages focus, accountability and entrepreneurial decision-making. Our R&D, regional marketing and sales teams are integrated into the Molecular Diagnostics and Life Sciences business areas to connect our innovation and commercial activities directly with growing markets.

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~~Drive platform success, particularly for QIAsymphony and QIAensemble systems~~

~~Add content by bringing new tests to market across all customer classes~~

~~Broaden geographic presence, especially in high-growth emerging markets~~

~~Grow efficiently and effectively with sustained growth and improved profitability~~

Research and Development

~~QIAGEN invests more in research and development, which totaled $130.6 million in 2011, or 11% of sales, than most companies in our industry.~~ We are committed to expanding ~~QIAGEN's~~our global leadership in Sample & Assay ~~Technologies as rapid advances in molecular biology open up new and useful applications.~~

Technologies. Our strategy for managing innovation focuses on addressing the most significant unmet medical and scientific needs. We target our resources to develop the most promising technologies for use by our customers in Molecular Diagnostics, Applied Testing, Pharma and Academia -– and to meet the needs of healthcare professionals and scientists in key geographic markets.

Innovation at QIAGEN follows parallel paths:

Creating new systems for automation of ~~workflows-platforms~~workflows – platforms for laboratories, hospitals and other users of these novel molecular technologies.

Expanding our broad portfolio of “content”~~-in~~ – in particular, novel assays to detect and characterize molecular structures and biomarkers for disease or genetic identification.

~~More than~~Our research and development investments are among the highest compared to other companies in our industry. Approximately 700 employees in research and development work in eight centers of excellence on four continents. Our comprehensive intellectual property portfolio spans more than 1,000 granted patents and more than ~~1,000~~900 pending applications.

Innovations in instrumentation are strengthening our leadership in the automation of ~~these technologies,~~laboratories, driving dissemination of molecular technologies in healthcare and other fields, and generating increased demand for ~~QIAGEN~~our consumable products. We continue to extend our modular, medium-throughput QIAsymphony platform, enabling hospitals and other customers to adopt or greatly expand their use of molecular diagnostics. QIAsymphony RGQ, designed to allow fully integrated processing from initial sample to final result, has expanded the QIAsymphony installed base since the launch of the fully integrated system in late 2010. We plan to integrate modules in the future for specialized needs such as ~~pyrosequencing.~~next-generation sequencing. In late 2011, we ~~updated development plans for~~launched the QIAensemble ~~system,~~Decapper, the first instrument that automates the tedious process of handling liquid clinical sample vials, enhancing our high-throughput QIAensemble platform. In 2012, we announced an initiative to develop a ~~high-throughput~~new platform ~~based on~~for NGS with the ~~same core technologies~~workflow characteristics needed to expand NGS from its current focus in life science research into widespread use in healthcare and clinical research. We plan a phased market entry of ~~QIAsymphony, including plans to enable migration of QIAGEN assays between the two platforms.~~this platform in 2013.

~~QIAGEN is~~We are commercializing a deep pipeline of content: molecular assays for preventive screening and diagnostic profiling of diseases, tests for important biomarkers to guide personalized cancer therapies, and assays for a broad range of other targets. The rollout of QIAsymphony RGQ is accompanied by an extensive development program involving assays for Molecular Diagnostics and other customer classes. ~~Regulatory~~U.S. regulatory submissions ~~planned for~~made in 2012 include a companion ~~diagnostics~~diagnostic for a new cancer ~~drugs~~drug targeting EGFR (epidermal growth factor receptor) and our pre-molecular assay for cytomegalovirus infection (CMV) in ~~the U.S. and the BRAF gene in the European Union and molecular and pre-molecular assays for the infectious disease CMV (cytomegalovirus).~~transplant patients. In Applied Testing, QIAGEN continues to develop new content for human identification, food safety and veterinary diagnostics. We are also expanding our extensive portfolio of products for disease pathway research by Pharma and Academic customers. In addition, we are developing assays for specific applications in key markets such as China and Japan. The total combined addressable markets for ~~QIAGEN's~~our current assay development portfolio ~~total more than~~approach $1 billion in potential annual sales.

In addition, ~~QIAGEN has invested~~we are investing in co-development of companion diagnostics for personalized healthcare through projects with pharmaceutical and biotech companies. ~~We have created a center of excellence in companion diagnostics in Manchester, U.K.~~ These programs typically begin with development of targeted assays to assist our customers in the clinical development of new drugs by identifying patient populations most likely to respond favorably to specific therapies. The collaborations have potential to develop into companion diagnostics marketed commercially along with the new drugs.

Sales and Marketing

We market our products in more than 100 countries throughout the world. We have established subsidiaries in markets we believe have the greatest sales potential in the Americas, Europe, Australia and Asia. We have established a network of experienced ~~marketing~~ personnel ~~and employ a field sales force of more than 1,500 people,~~ who sell ~~QIAGEN~~our products and provide direct support to customers. A significant number of marketing and sales staff members are experienced scientists with academic degrees in molecular biology or related areas. In addition, business managers oversee relationships with key accounts to ensure that ~~QIAGEN~~we are is serving their needs on the commercial side, such as procurement systems, financing arrangements, data on the costs and value of our systems, and collaborations among organizations. We also have specialized independent distributors and importers in many markets.

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Our marketing strategy focuses on providing high-quality products that offer customers unique value, coupled with commitment to technical excellence and customer service. We have developed a range of marketing tools to provide customers with direct access to technical support and to inform them of new product offerings, as well as to enhance ~~QIAGEN's~~our reputation for technical excellence, high-quality products and commitment to customer service. One such tool is our technical service hotline, which allows existing or potential customers to discuss a wide range of technical questions regarding our products and related molecular biology procedures, via phone or e-mail, with Ph.D. and M.Sc. scientists in our technical service group. Frequent

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communication with customers enables us to identify market needs, gain early insight into new developments and business opportunities, and address them with new products.

~~QIAGEN's~~Our GeneGlobe online portal (www.geneglobe.com) has become a valuable outreach to life science researchers in Pharma and Academia by providing an industry-leading resource on disease pathways, biomarkers and genomic information. GeneGlobe provides searchable, annotated data on 60,000 pathway and gene-related technologies, with links to order products related to each avenue of investigation.

We also distribute several publications, including our catalog, to existing and potential customers worldwide, providing new product information, product updates, and articles by customers and by our scientists about existing and new applications. Our website (www.qiagen.com) contains a full online product catalog and ordering system, as well as a host of support tools, scientific design tools and other resources. We have full Japanese and Chinese language versions of our website, and some information is available on our site in French, German and Korean to support these markets. Information contained on our website, or accessed through it, is not part of this Annual Report. In addition, ~~QIAGEN holds~~we hold numerous scientific seminars to present technical information at leading clinical, academic and industrial research institutes worldwide. We conduct direct marketing campaigns to announce new products or offer special promotions, and we offer personalized electronic newsletters with useful information for molecular biology applications.

In addition to keeping customers informed of new product offerings, we offer an inventory consignment program. The QIAcabinet is a storage cabinet owned by ~~the company~~us and placed in customer laboratories at their request. Stocked with ~~QIAGEN~~our products, the QIAcabinet offers customers the convenience of immediate access, reducing reorder procedures and shipping costs. We monitor cabinet inventory and bill the customers at regular intervals as products are used. QIAcabinet increases our visibility in the laboratory and helps maintain our competitive position, while reducing distribution costs.

Seasonality

Our business does not experience significant, predictable seasonality. Historically, a significant portion of our sales have been to researchers, universities, government laboratories and private foundations whose funding is dependent upon grants from government agencies, such as the National Institutes of Health and similar bodies. To the extent that our customers experience increases, decreases or delays in funding arrangements and budget approvals, and to the extent that any of our customers' activities are slowed, such as during times of higher unemployment, vacation periods or delays in the approval of government budgets, including the U.S. federal government's budget, we may experience fluctuations in sales volumes during the year or delays from one period to the next in the recognition of sales.

Intellectual Property, Proprietary Rights and Licenses

We have made and expect to continue to make investments in intellectual property. In ~~2011,~~2012, our purchases of intangible assets totaled ~~$34.6 million.~~$26.1 million. While we do not depend solely on any individual patent or technology, we are significantly dependent in the aggregate on technology that we own or license. Therefore, we consider protection of proprietary technologies and products one of the major keys to our business success. We rely on a combination of patents, licenses and trademarks to establish and protect proprietary rights. As of December 31, ~~2011,~~2012, we owned ~~186~~193 issued patents in the United States, ~~136~~143 issued patents in Germany and ~~740~~767 issued patents in other major industrialized countries. We have over ~~1,000~~972 pending patent applications. Our policy is to file patent applications in Western Europe, the United States and Japan. U.S. patents have a term of 17 years from the date of issue (for patents issued from applications submitted prior to June 8, 1995), or 20 years from the date of filing (in the case of patents issued from applications submitted on or after June 8, 1995). Patents in most other countries have a term of 20 years from the date of filing the patent application. We intend to aggressively prosecute and enforce patents and to otherwise protect our proprietary technologies. We also rely on trade secrets, know-how, continuing technological innovation and licensing opportunities to develop and maintain our competitive position.

Our practice is to require employees, consultants, outside scientific collaborators, sponsored researchers and other advisers to execute confidentiality agreements upon commencement of their relationships with us. These agreements provide that all confidential information developed by or made known to the individual during the course of the relationship is to be kept confidential and not disclosed to third parties, subject to a right to publish certain information in scientific literature in certain circumstances and to other specific exceptions. In the case of our employees, the agreements provide that all inventions

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conceived by individuals in the course of their employment will be our exclusive property.

See “Risk Factors” included in Item 3 above for details regarding risks related to our reliance on patents and proprietary rights.

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Competition

WeIn the Academic and Pharmaceutical markets, we believe our primary competition in sample technology products involves traditional separation and purification methods, such as phenol extraction, cesium chloride density gradient centrifugation, and precipitation. These methods utilize widely available reagents and other chemicals supplied by companies such as Sigma-Aldrich Corp. and Roche Diagnostics GmbH (Applied Sciences Division). We compete with these methods through our innovative technologies and products, which offer a comprehensive solution for nucleic acid collection, pre-treatment, separation and purification needs and provide significant advantages in speed, reliability, convenience, reproducibility and ease of use.

We also experience competition in various markets from other companies providing sample preparation products in kit form and assay solutions. These competitors include, but are not limited to, Promega Corp., EMD Millipore ~~Corp.,~~or Merck Millipore, and Macherey-Nagel GmbH for nucleic acid separation and purification; Life Technologies Corp. and Promega Corp. for assay solutions and for transfection reagents; and Sigma-Aldrich Corp. and Fisher Scientific for protein fractionation products. We believe our proprietary technologies and products offer significant advantages over competitors' products with regard to purity, speed, reliability and ease-of-use.

The medical diagnostics and biotechnology industries are subject to intense competition. In our HPV franchise within our molecular diagnostics customer class, we face competition from well-established diagnostic technologies, such as cytology, and from emerging HPV testing approaches, such as signal amplified testing, research-based PCR, other indicators of disease and other traditional testing methods developed by laboratories. Our competitors include companies such as Roche Diagnostics GmbH and ~~Gen-Probe, Inc., whose HPV tests were approved in the U.S. during the second half of 2011, as well as~~ Hologic, Inc., which ~~has~~have been marketing FDA-approved HPV testing products in the U.S. in recent years. We expect competition to intensify, but ~~QIAGEN's~~our leading position in the HPV market is supported by our marketing efforts and the data supporting our ~~“gold standard”~~ digene HPV Test. We believe we have a competitive advantage driven by the fact that ~~more than 80~~close to 90 million of these tests have been distributed worldwide as well as a multitude of clinical trials encompassing more than one million women. These clinical trial results, many of which have been published in peer-reviewed journals such as the New England Journal of Medicine, have validated that our HPV test products, used alone or in conjunction with the Pap test, demonstrate high clinical sensitivity and high negative predictive value for diagnosis of cervical disease and cancer. In addition to the industry-leading clinical performance of our assay, ~~considering~~our automation systems offer other competitive benefits, for the high-volume ~~needs of the~~ HPV testing market, ~~QIAGEN has another competitive benefit in terms of its offering for HPV testing automation systems,~~ including performance and reliability, ease of use, standardization, cost, proprietary position and regulatory approvals. ~~In 2011, multiyear contracts were concluded with~~The QIAensemble Decapper, a unique instrument that automates time-consuming manual steps for handling liquid sample vials, was added for the U.S. market in late 2011. A number of major U.S. customers for HPV screening ~~products. Also~~products operate under multiyear contracts with us, in ~~late 2011, QIAGEN launched the QIAensemble Decapper in the U.S.,~~ which ~~automates several manual processing steps.~~we provide competitive pricing and other benefits.

~~The medical diagnostics and biotechnology industries are subject to intense competition.~~ Some of our other products within our molecular diagnostics customer class, such as tests for Chlamydia, Gonorrhea, hepatitis B virus, herpes simplex virus and ~~cytomegalovirus,~~CMV, compete against existing screening, monitoring and diagnostic technologies, including tissue culture and antigen-based diagnostic methodologies. Our competitors for gene-based diagnostic probes include Roche Diagnostics, Abbott, Siemens and ~~Gen-Probe.~~Hologic. We believe the primary competitive factors in the market for gene-based probe diagnostics and other screening devices are clinical validation, performance and reliability, ease of use, standardization, cost, proprietary position, competitors' market shares, access to distribution channels, regulatory approvals and availability of reimbursement.

We do not believe our competitors have the same comprehensive approach to Sample & Assay Technologies as ~~QIAGEN~~we do or the ability to provide the broad range of technologies and depth of products and services that we offer. With our complete range of manual and fully automated solutions, we believe we offer the value of standardization of procedures and, therefore, more reliable results. We also believe our integrated strategic approach gives us a competitive advantage. The quality of sample ~~preparation-a field~~preparation-an area in which we have a unique market and leadership position-is a key prerequisite for reliable molecular assay solutions, which increasingly are being applied in emerging markets such as Molecular Diagnostics and Applied Testing.

Current and potential competitors may be in the process of seeking FDA or foreign regulatory approvals for their respective products. ~~QIAGEN's~~Our continued future success will depend in large part on our ability to maintain our technological advantage over competing products, expand our market presence and preserve customer loyalty. There can be no assurance that we will be able to compete effectively in the future or that development by others will not render our technologies or products non-competitive.

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Suppliers

As part of our quality assessment procedures, we periodically evaluate the performance of our raw material and component suppliers, potential new alternative sources of such materials and components, and the risks and benefits of reliance on our existing suppliers. We buy materials for our products from many suppliers, and are not dependent on any one supplier or group of suppliers for our business as a whole. Raw materials generally include chemicals, raw separation media, biologics,

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plastics and packaging. Raw materials are generally readily available at competitive, stable prices from a number of suppliers. Certain raw materials are produced under our specifications, so we closely monitor stock levels to maintain adequate supplies. We believe we maintain inventories ~~of raw materials~~ at a sufficient level to ensure reasonable customer service levels and to guard against normal volatility in availability.

Government Regulations

We are not subject to direct regulation other than regulation generally applicable to businesses pursuant to various laws and regulations in effect in the different jurisdictions in which we operate, including laws and regulations applicable to environmental matters, such as the handling and disposal of hazardous wastes.

Our research and development activities involve the controlled use of small amounts of hazardous materials, chemicals and radioactive compounds. Although we believe that our safety procedures for handling and disposing of such materials comply with the standards prescribed by applicable regulations, such as the United States Occupational Safety and Health Administration's, or OSHA, Hazard Communication and Occupational Exposure to Hazardous Chemicals in Laboratories standards, the risk of accidental contamination or injury from these materials cannot be completely eliminated. In the event of such an accident, we could be held liable for any damages that result, and any such liability could have a material adverse effect on us.

We also comply with the OSHA Bloodborne Pathogens standard and the Center for Disease Control/National Institutes of Health Biosafety in Microbiological and Biomedical Laboratories standards for the handling of biological materials and comply with the United States Department of Transportation and International Air Transport Association regulations for the shipping of our kits which contain materials classified as hazardous. There are other federal, state and local laws and regulations applicable to our business, including those of the United States Environmental Protection Agency and the Maryland Department of the Environment. However, we do not expect that compliance with governmental regulations to which we are subject will have a material effect on our capital expenditures, earnings or competitive positions.

International sales of in vitro diagnostic (IVD) and other medical devices are subject to the regulatory requirements of each country or defined economic region, such as the European Union. The regulatory review process varies from country to country and many countries also impose product standards, packaging requirements, labeling requirements and import restrictions on devices.

In the United States, IVDs are regulated by the FDA as medical devices. Medical devices are classified into one of three classes on the basis of the controls deemed by the FDA to be necessary to reasonably ensure their safety and effectiveness. Class I devices are subject to general controls, including labeling, premarket notification and adherence to FDA's quality system regulations, which are device-specific good manufacturing practices. Class II devices are subject to general controls and special controls, including performance standards and postmarket surveillance. Class III devices are subject to most of the previously identified requirements as well as to premarket approval. Class I devices are exempt from premarket submissions to the FDA; most Class II devices require the submission of a 510(k) premarket notification to the FDA; and Class III devices require submission of a premarket approval application, or PMA. Most in vitro diagnostic kits are regulated as Class I or Class II devices and are either exempt from premarket notification or require a 510(k) submission.

A 510(k) notification must demonstrate that a medical device is substantially equivalent to another legally marketed device, termed a “predicate device,” that is legally marketed in the United States and for which a PMA was not required. A device is substantially equivalent to a predicate device if it has the same intended use and technological characteristics as the predicate, or has the same intended use but different technological characteristics, where the information submitted to the FDA does not raise new questions of safety and effectiveness and demonstrates that the device is at least as safe and effective as the legally marketed device. Most 510(k)s do not require clinical data for clearance, but a minority will. The FDA is supposed to issue a decision letter within 90 days of receipt of the 510(k) if it has no additional questions or send a first action letter requesting additional information within 75 days. Requests for additional data, including clinical data, will increase the time necessary to review the notice. If the FDA does not agree that the new device is substantially equivalent to the predicate device, the new medical device is automatically classified as a Class III device for which a PMA will be required. However, the sponsor may petition the FDA to make a risk-based determination that the device does not pose the type of risk associated with Class III devices and down-classify the device to Class I or Class II.

Class III devices, such as our HC2 HPV test, require the submission and approval of a PMA prior to product sale. The PMA process is more complex, costly and time consuming than the 510(k) process. A PMA must be supported by more detailed

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and comprehensive scientific evidence, including clinical data, to demonstrate the safety and efficacy of the medical device for its intended purpose. If the device is determined to present a “significant risk,” the sponsor may not begin a clinical trial until it submits an investigational device exemption, or IDE, to the FDA and obtains approval from the FDA to begin the trial. After the PMA is submitted, the FDA has 45 days to make a threshold determination that the PMA is sufficiently complete to permit

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a substantive review. If the PMA is complete, the FDA will file the PMA. The FDA is subject to a performance goal review time for a PMA of 180 days from the date of filing, although in practice this review time is longer. Questions from the FDA, requests for additional data and referrals to advisory committees may delay the process considerably. The total process may take several years, and the FDA may also request additional clinical data as a condition of approval or after the PMA is approved. Product changes after approval typically require a supplemental submission with FDA review cycles ranging from 30 to 180 days.

Any products manufactured or distributed pursuant to FDA clearances or approvals are subject to pervasive and continuing regulation by the FDA, including recordkeeping requirements, reporting of adverse experiences with the use of the device, and restrictions on advertising and promotion. Device manufacturers are required to register their establishments and list their devices with the FDA and are subject to periodic inspections by the FDA and certain state agencies. Noncompliance with applicable FDA requirements can result in, among other things, warning letters, fines, injunctions, civil penalties, recalls or seizures of products, total or partial suspension of production, refusal of the FDA to grant 510(k) or PMA approval for devices, withdrawal of 510(k) clearances and/or PMA approvals, or criminal prosecution.

Some of our test kits are sold for research use only in the United States. We do not promote these tests for clinical diagnostic use, and they are labeled “For Research Use Only” or RUO, as permitted by FDA regulations.

Receipt and maintenance of regulatory authorization to market and sell our products is vital to future success. In addition to seeking regulatory authorizations for our products, we work with other companies to seek regulatory clearance or approval for use of their products to provide the specimens necessary to perform our diagnostic tests. The time, money and resources required for new product clearances or approvals by the FDA and foreign authorities is unpredictable, and the necessary approvals or clearances may not be granted on a timely basis or at all. Delays or failure to receive such approvals or clearances could have a material adverse effect on our business, financial condition and results of operations.

The Physician Payment Sunshine Act, or Sunshine Act, which was enacted as part of the Affordable Care Act, or ACA, requires applicable manufacturers of drugs, devices, biologicals, or medical supplies covered under Medicare, Medicaid or the Children's Health Insurance Program, to report annually to the Secretary of the Department of Health and Human Services payments or other transfers of value made by that entity, or by a third party as directed by that entity, to physicians and teaching hospitals, or to third parties on behalf of physicians or teaching hospitals, during the course of the preceding calendar year. The Final Rule implementing the Sunshine Act, published on February 8, 2013, requires data collection on payments to begin on August 1, 2013. The first annual report, comprised of data collected from August 1, 2013 to December 31, 2013, is due March 31, 2014. Failure to comply with the reporting requirements can result in significant civil monetary penalties ranging from $1,000 to $10,000 for each payment or other transfer of value that is not reported (up to a maximum per annual report of $150,000) and from $10,000 to $100,000 for each knowing failure to report (up to a maximum per annual report of $1 million). We will be required to collect data on these payments and report such payments.

Recent U.S. legislation has been enacted to improve transparency and accountability concerning the sourcing of conflict minerals” from mines located in the conflict zones of the Democratic Republic of Congo (DRC) and its adjoining countries. The term conflict minerals currently encompasses tantalum, tin, tungsten (or their ores) and gold. Certain of our instrumentation product components which we purchase from third party suppliers do contain gold. This U.S. legislation requires manufacturers, such as us, to investigate our supply chain and disclose if there is any use of conflict minerals originating in the DRC or adjoining countries. We are currently evaluating the potential impact of, and developing an implementation strategy for, this legislation.

Organizational Structure

QIAGEN N.V. is the holding company for more than 50 consolidated subsidiaries, ~~the majority~~many of which have the primary function of ~~the distribution of~~distributing our products and services on a regional basis. Certain subsidiaries also have research and development or production activities. A listing of our significant subsidiaries and their jurisdictions of incorporation is included in Exhibit 8.1 to this Annual Report.

Description of Property

~~QIAGEN's~~Our production and manufacturing facilities for consumable products are located in Germany, the United States, China, France, and the United Kingdom. Our instrument production facilities are located in Switzerland. In recent years, we have made investments in automated and interchangeable production equipment to increase our production capacity and improve efficiency. Our production and manufacturing operations are highly integrated and benefit from sophisticated inventory control. Production management personnel are highly qualified, and many have advanced degrees in engineering, business and science. We also have installed and continue to expand production-planning systems that are included in our integrated information and control system based on the SAP R/3 business software package from SAP AG. Worldwide, we use SAP software to integrate

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most of our operating subsidiaries. Capital expenditures for property, plant and equipment totaled ~~$86.8~~$102.0 million ~~$79.7~~, $86.8 million and ~~$52.2~~$79.7 million for 2012, 2011 ~~2010~~ and ~~2009,~~2010, respectively.

~~QIAGEN has~~We have an established quality system, including standard manufacturing and documentation procedures, intended to ensure that products are produced and tested in accordance with the FDA's Quality System Regulations, which impose current Good Manufacturing Practice (cGMP) requirements. For cGMP production, special areas were built in our facilities in Hilden, Germany, and Germantown and Gaithersburg, Maryland. These facilities operate in accordance with cGMP requirements.

The consumable products manufactured at QIAGEN GmbH in Germany, and QIAGEN Sciences, Inc. and QIAGEN Gaithersburg, Inc., both in Maryland, are produced under ISO 9001: 2000, ISO 13485:2003 for Medical Devices, and ISO 13485:2003 CMDCAS, and the EC Directive 98/79/EC for medical devices. QIAGEN Instruments AG in Switzerland, which produces the majority of our instrumentation product line, is also ISO 9001: 2000 and 13485:2003 certified. Our certifications form part of our ongoing commitment to provide our customers high-quality, state-of-the-art Sample & Assay Technologies and to the development of our Total Quality Management system.

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Our facilities in Hilden, Germany, currently occupy a total of approximately 755,000 square feet, some of which is leased pursuant to separate contracts, the last of which expires in 2018. Our production capacity is increased through our manufacturing and research facilities in the United States. QIAGEN Sciences, ~~Inc.~~LLC owns a 27-acre site in Germantown, Maryland. The ~~200,000~~285,000 square foot Germantown facility consists of several buildings in a campus-like arrangement and is intended to accommodate over ~~250~~500 employees. There is room for future expansion of up to ~~200,000~~300,000 square feet of facility space. We lease a facility in Gaithersburg, Maryland, comprising a total of 150,000 square feet and 40,000 square feet in Frederick, Maryland for manufacturing, warehousing, distribution and research operations.

In 2009, we purchased additional land adjacent to our facility in Hilden, Germany, for EUR 2.5 million (approximately $3.2 million) and began construction to further expand our facilities for research and development and production. In 2010, we began construction on expansion of our research, production and administrative space in Germantown, Maryland. While the construction in Germany is complete, the U.S. expansion projects are expected to continue into ~~2014,~~2013, with both projects estimated at a total cost of approximately $94.0 million, of which ~~$54.1~~$86.4 million had been incurred as of December 31, ~~2011.~~2012. We anticipate being able to fund these expansions with cash generated by operating activities.

Other subsidiaries throughout the world lease smaller amounts of space. Our corporate headquarters are located in leased office space in Venlo, The Netherlands.

We believe our existing and planned production and distribution facilities can support anticipated production needs for the next 36 months. Our production and manufacturing operations are subject to various federal, state, and local laws and regulations including environmental regulations. We do not believe we have any material issues relating to these laws and regulations.


Item 4A.	Unresolved Staff Comments

Not applicable.


Item 5.	Operating and Financial Review and Prospects

This section contains a number of forward-looking statements. These statements are based on current management expectations, and actual results may differ materially. Among the factors that could cause actual results to differ from management’s expectations are those described in “Risk Factors” ~~above,~~ and “Forward-looking and Cautionary Statements” ~~below.~~

~~Forward-looking and Cautionary Statements~~

This report contains forward-looking statements that are subject to risks and uncertainties. These statements can be identified by the use of forward-looking terminology, such as “believe,” “hope,” “plan,” “intend,” “seek,” “may,” “will,” “could,” “should,” “would,” “expect,” “anticipate,” “estimate,” “continue” or other similar words. Such statements are based on management’s current expectations and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. We caution investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors, including, but not limited to, the following: risks associated with our expansion of operations, including the acquisition of new businesses; variability in our operating results from quarter to quarter; management of growth, international operations, and dependence on key personnel; intense competition; technological change; our ability to develop and protect proprietary products and technologies and to enter into and maintain collaborative commercial relationships; our future capital requirements; general economic conditions and capital market fluctuations; and uncertainties as to the extent of future government regulation of our business. As a result, our future success involves a high degree of risk. For further information, refer to the more specific risks and uncertainties discussed under the caption “Risk Factors” in Item 3 ~~and throughout~~of this Annual Report.

Results of Operations

Overview

~~QIAGEN is~~We are the world's leading provider of innovative Sample & Assay Technologies, based on independent market studies of United States and European market shares for our products and technologies. Our automated systems and consumable products empower customers to transform raw biological samples into valuable molecular information. Sample technologies are used to isolate DNA, RNA and proteins from any biological sample, such as blood or tissue. Assay technologies are then used to amplify, enrich and provide results for analysis of biomolecules, such as the DNA of a virus or a mutation of a gene.

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We sell our products, sample and assay kits known as consumables and automated instrumentation systems using those technologies, to four major customer classes:

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Molecular Diagnostics-healthcare providers supporting many aspects of patient care including prevention, profiling of diseases, personalized healthcare and point of need testing

Applied Testing~~-customers~~- government or industry customers using molecular technologies in fields such as forensics, veterinary diagnostics and food safety testing

Pharma-drug discovery and development efforts of pharmaceutical and biotechnology companies

Academia-researchers exploring the secrets of life such as the mechanisms and pathways of diseases, and in some cases translating that research into drug targets or commercial applications

~~QIAGEN markets~~We market products in more than 100 countries throughout the world. We have established subsidiaries in markets we believe have the greatest sales potential, including countries throughout Europe, Asia, the Americas and Australia. We also work with specialized independent distributors and importers. As of December 31, ~~2011,~~2012, we employed approximately ~~3,900~~4,000 people in more than 35 locations worldwide.

In ~~2011~~2012, operating income on a consolidated basis was ~~$99.6~~$169.8 million, a 71% increase from $99.6 million in 2011, which in turn was a 47% decline compared from $188.5 million in 2010~~, which in turn was a 5% increase compared from~~ ~~$180.2~~ ~~million in~~ ~~2009~~. The 2011 decline was due to the impact of a restructuring-related charge in the fourth quarter of ~~2011 as well as charges related to the acquisitions of Cellestis and Ipsogen.~~2011.

We have delivered five-year compound annual growth rates of approximately ~~20%~~14% in net sales and 6%21% in net income through ~~2011~~2012, as reported under U.S. GAAP. We have funded our growth through internally generated funds, debt, and private and public sales of equity securities.

Recent Acquisitions

~~QIAGEN has~~We have made a number of strategic acquisitions since ~~2009,~~2010, expanding our technology and product offerings as well as extending our geographic presence. These transactions include:

In June 2012, we unveiled an initiative to enter the NGS market, including our early 2012 acquisition of Intelligent Bio-Systems, Inc., which added important expertise and innovative technologies in this emerging field. Our NGS initiative aims to expand next-generation sequencing technologies from the current focus on life science research into routine use in clinical research and molecular diagnostics. The expected sample-to-result workflows will incorporate a next-generation benchtop sequencer, our QIAcube and QIAsymphony automation platforms, leading sample preparation solutions, specialized gene panels and GeneGlobe (www.geneglobe.com) portfolio of more than 60,000 well-defined and characterized molecular assays. New bioinformatics, including NGS solutions from a new collaboration with SAP AG, will handle clinical data produced in next-generation sequencing. Our new NGS platform is expected to be phased into the market in 2013.


•	In May 2012, we acquired AmniSure International LLC, including the AmniSure^® assay for determining whether a pregnant woman is suffering rupture of fetal membranes (ROM), a widespread cause of premature delivery and neonatal complications. This product, which is approved in the U.S. and many other markets, is expected to be catalytic for our Point of Need portfolio.

•

In August 2011, we acquired Cellestis Ltd., ~~a publicly listed~~an Australian company that ~~develops and provides in-vitro diagnostics and life science research products based on its~~created the proprietary “pre-molecular” QuantiFERON^® technology. The technology provides information on the activity of the cell-mediated functions of the immune system from whole blood samples. By tapping into the body’s memory system, this approach allows detection of diseases much earlier than other diagnostic methods, such as PCR. Withearly-warning QuantiFERON^®,-TB Gold test, which detects latent tuberculosis (TB) infection as a strategy for the prevention of active TB disease in vulnerable populations, has become an important growth driver in 2012. Also in 2012, we ~~are adding a “pre-molecular” technology that is complementary to our DNA-based molecular testing franchise.~~submitted the QuantiFERON^® ~~is a trademark of Cellestis, Ltd.~~-CMV test to the FDA for use in diagnosing cytomegalovirus (CMV).

In July 2011, we ~~entered into binding agreements with a group of major shareholders of Ipsogen S.A. and~~ purchased a majority of the ~~Ipsogen shares.~~shares of Ipsogen S.A., a publicly listed French company that is a global leader in molecular profiling and personalized healthcare diagnostics for a broad range of blood cancers. ~~In October 2011, we initiated~~Through a public tender offer for the remaining ~~shares. By year-end 2011,~~shares, we had acquired 89% of the shares of ~~Ipsogen. QIAGEN intends~~Ipsogen by year-end 2012. We intend to fully acquire Ipsogen through future public offers. Effective January 1, 2013, Ipsogen was renamed QIAGEN Marseille and its sales and distribution networks were integrated with our commercial operations.

In January 2010, we acquired ESE GmbH, now QIAGEN Lake Constance GmbH, a German developer and manufacturer of portable, battery-operated, “ultra-fast time to result” multiplex UV and fluorescence optical measurement devices. ESE’s systems for point of need testing in healthcare and applied testing enable low-throughput molecular testing in physician practices, emergency rooms, remote field areas, and other settings where a laboratory infrastructure is not accessible and fast turnaround is required.

In December 2009, we acquired SABiosciences Corporation, a U.S. company that holds a leading position in the design and commercialization of disease- and pathway-focused real-time PCR-based assay panels (PCR Arrays), which are widely utilized in biomedical research and in development of new drugs and diagnostics.

In September 2009, we acquired DxS Ltd, now QIAGEN Manchester, a pioneer in development and marketing of companion diagnostics that enable physicians to predict patient responses in order to make cancer therapies more effective. Headquartered in the U.K., QIAGEN Manchester, Ltd brings a portfolio of molecular diagnostic assays and related intellectual property, as well as a deep pipeline of companion diagnostic partnerships in oncology with leading pharmaceutical companies. The acquisition has given QIAGEN a leading position in personalized healthcare and strengthen our overall strategic position in Molecular Diagnostics.

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Our financial results include the contributions of our recent acquisitions from the date of acquisition, as well as costs related to the acquisitions and integrations of the acquired companies, such as the relocation and closure of certain facilities.

~~Other Changes~~

~~During 2010, we~~We determined that ~~QIAGEN operates~~we operate as one business segment in accordance with ASC Topic 280, Segment Reporting. Our ~~decision-making process has evolved as a result of continued growth, restructuring and streamlining of the organization, and revised internal budgeting and reporting approaches. Our~~ chief operating decision maker (CODM) ~~now~~ makes decisions on business operations and resource allocation based on evaluations of the QIAGEN Group as a whole. With revenues derived from our entire product and service offerings, it is not practicable to provide a detail of revenues for each group of similar products and services or for each customer group, as full discrete financial information is not available. Considering the acquisitions made during ~~2011,~~2012, we determined that we still operate as one business segment. However, we do provide certain revenue information by customer class to allow better insight into our operations. This information is estimated using certain assumptions to allocate revenue among the customer classes.

Year Ended December 31, 2012, Compared to 2011

Net Sales

In ~~March 2010,~~2012, net sales increased 7% to $1.25 billion compared to $1.17 billion in 2011. This increase in net sales was driven by business expansion in all customer classes - particularly Molecular Diagnostics and Applied Testing - and all geographic regions. Contributions from the acquisitions of Ipsogen (until July 2012), Cellestis (until August 2012) and AmniSure (acquired in May 2012) provided six percentage points of total growth, and the rest of our portfolio provided four percentage points. Currency movements had a negative impact of three percentage points on reported sales growth. In 2012, consumable and related revenues, which represent approximately 87% of total sales, increased 7% as compared to 2011. Sales of instrumentation products, which represent 13% of net sales, increased 7% in 2012. Instrument sales benefited during 2012 from demand for a broad range of QIAGEN instruments. We exceeded our 2012 goal for more than 200 new placements of the QIAsymphony automation platform, reaching an installed base of more than 750 platforms. Approximately 70% of total QIAsymphony placements as of the end of 2012 have been with Molecular Diagnostics customers, primarily through reagent rental agreements where revenues are recognized over a multiyear period. Demand also has been strong among Applied Testing customers.

The Asia-Pacific / Japan region (+14% growth, 19% of sales) grew at a robust pace in 2012 on improving demand in China, Japan and our top emerging markets which include India and Korea. Results in the Europe / Middle East / Africa region (+2% growth, 33% of sales) advanced on higher sales in northern European countries and growth in all customer classes. The Americas (+8% growth, 47% of sales) rose on higher contributions from Molecular Diagnostics and Applied Testing, more than offsetting lower HPV sales in the region.

In Molecular Diagnostics, which represents approximately 49% of net sales, we achieved an increase of 13% of net sales in 2012 compared to 2011. Healthcare-related sales advanced in 2012, driven by new products and solid demand for instruments, particularly the QIAsymphony automation platform. In Prevention, the QuantiFERON-TB test (acquired with Cellestis in 2011) achieved growth in 2012 on initiatives in the U.S. ~~President signed~~and Europe to drive greater use of this new test for latent tuberculosis (TB). Full-year 2012 sales of products used in HPV testing performed in line with expectations, as steady volumes in the ~~Patient Protection~~U.S. were more than offset by pricing pressure from the implementation of multiyear customer agreements. Personalized Healthcare delivered ongoing strong growth on global demand for the therascreen portfolio of companion diagnostic kits - particularly the KRAS test launched in mid-2012 after FDA approval for use in metastatic colorectal cancer patients - as well as higher revenues from co-development projects with pharmaceutical companies. In Point of Need, the AmniSure assay for premature rupture of fetal membranes in pregnant women provided important contributions after its acquisition in May 2012.

In Applied Testing, which represents approximately 8% of net sales, we achieved 19% growth in 2012 compared to 2011, primarily on strong demand for consumables used in in human identification / forensics, veterinary medicine and ~~Affordable Care Act~~food safety. Instrument sales also advanced in 2012, particularly following the early 2012 launch of assays for use on the QIAsymphony automation platform.

In Pharma, which represents approximately 19% of net sales, we experienced 3% growth in 2012 compared to 2011, led by a demand for products used in oncology research as well as the GeneGlobe portfolio. Also contributing to the growth was ongoing expansion of Certal products used on QIAsymphony for quality control in biopharmaceutical processing. However, growth rates were slower in the second half of 2012 as restructuring activities at some pharmaceutical companies impacted results.

In Academia, which represents approximately 24% of net sales, we experienced a 2% decline in 2012 compared to 2011 primarily due to currency movements. Concerns about future U.S. and European government funding for life sciences research prompted very cautious spending patterns among some customers in the U.S. and Europe in the fourth quarter of 2012. Funding

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uncertainties in these regions are expected to continue in 2013.

Gross Profit

Gross profit was $824.0 million, or 66% of net sales, in 2012, compared to $749.8 million, or 64% of net sales, in 2011. Generally, our consumable sample and assay products have a ~~reconciliation bill that amended~~higher gross margin than our instrumentation products and service arrangements. Fluctuations in the ~~Health Care~~sales levels of these products and ~~Education Reconciliation Act~~services can result in fluctuations in gross margin between periods. An increase in milestone payments from companion diagnostic co-development arrangements in 2011 negatively affected the 2011 margin since the gross margin on these services is significantly below the margin on product sales. Gross margin in 2011 also was negatively impacted by costs related to the relocation of ~~2010 (collectively,~~production facilities, including moving into newly constructed production space in Hilden, Germany; costs incurred following the ~~“Acts”). As~~Japanese earthquake and other natural disasters; and costs related to the restructuring announced late in 2011.

Amortization expense related to developed technology and patent and license rights acquired in a business combination is included in cost of sales. The amortization expense on acquisition-related intangibles within cost of sales increased to $78.5 million in 2012 from $70.2 million in 2011, as a result of an increase in intangibles acquired in recent business combinations. We expect our acquisition-related intangible amortization to continue to increase as a result of acquisitions.

During 2012, a total of $3.1 million was expensed to acquisition and restructuring-related cost of sales. These costs included costs related to the ~~Acts,~~relocation of production facilities as well as the write-up of acquired inventory to fair market value as a result of business combinations. In accordance with purchase accounting rules, acquired inventory was written up to fair market value and subsequently expensed as the inventory was sold. Additionally, we recorded reversals of $6.7 million related to changes in the fair value of contingent consideration and $4.6 million related to acquired contingent liabilities.

During 2011, a total of $9.6 million was expensed to acquisition and restructuring-related cost of sales. These costs included costs related to the relocation of production facilities as well as the write-up of acquired inventory to fair market value as a result of business combinations.

Research and Development

Research and development expenses decreased by 6% to $122.5 million (10% of net sales) in 2012, compared to $130.6 million (11% of net sales) in 2011. The decline was partially due to a refocusing of our portfolio of development projects in early 2012. Research and development expense was also positively affected by $5.8 million of currency exchange impact in 2012. As we continue to discover, develop and acquire new products and technologies, we expect to incur additional expenses related to facilities, licenses and employees engaged in research and development efforts. Additionally, research and development costs are expected to increase as a result of seeking regulatory approvals, including U.S. FDA Pre-Market Approval (PMA), U.S. FDA 510(k) clearance and EU CE approval of certain assays or instruments. We have a strong commitment to innovation and expect to continue to make investments in our research and development efforts.

Sales and Marketing

Sales and marketing expenses increased 12% to $343.5 million (27% of net sales) in 2012 from $307.3 million (26% of net sales) in 2011. The increase in sales and marketing expenses reflects the acquisitions in 2012 along with increased sales and marketing investments to globalize the acquired Cellestis and Ipsogen product portfolios. The increase was partially offset by $10.2 million of favorable currency exchange impact in 2012. Sales and marketing expenses are primarily associated with personnel, commissions, advertising, trade shows, publications, freight and logistics expenses and other promotional expenses. In addition, the sales and marketing expenses include the costs of maintaining separate sales organizations addressing customers in Molecular Diagnostics, Applied Testing, Pharma and Academia. We anticipate that sales and marketing costs will continue to increase along with new product introductions and growth in sales of our products, but we expect sales and marketing costs will grow at a slower rate than our overall revenue growth over the long term.

Starting January 1, 2013, the United States began imposing a 2.3% excise tax ~~will be imposed~~ on the sale, including leases, of any ~~taxable medical devices by the manufacturer, producer or importer of such devices. A~~ “taxable medical ~~device”~~device,” that is any FDA-regulated device intended for human ~~use. The excise~~use, under the U.S. healthcare reform laws enacted in 2010. Based on our estimate of product revenue that is expected to be subject to the regulations, we currently expect that imposition of the tax will ~~apply~~cost up to ~~U.S. sales~~$6.0 million annually in 2013 and will be recorded as a selling expense.

General and Administrative, Restructuring, Integration and Other

General and administrative, business integration, restructuring and related costs decreased by 18% to $152.1 million (12% of ~~all taxable medical devices occurring after December 31, 2012. While~~net sales) in 2012 from $185.5 million (16% of net sales) in 2011. The net decrease is due primarily to the restructuring measures that started in late 2011 to streamline the organization. We expensed $41.0 million and $69.4 million in 2012 and 2011, respectively, to general and administrative restructuring costs related to internal restructuring of subsidiaries,

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including severance and retention costs. The restructuring costs primarily relate to a project we began in late 2011 to enhance productivity by streamlining the organization and freeing up resources for reallocation to strategic initiatives to help drive growth and innovation, strengthen our industry leadership position and improve longer-term profitability. This project was focused to eliminate organizational layers and overlapping structures, actions that will enhance our processes, speed and productivity. Additionally, general and administrative, integration and related costs decreased by $6.2 million due to currency impact in 2012, compared to the same period of 2011. During 2012, we incurred acquisition costs of approximately $4.5 million, primarily in connection with the acquisitions of AmniSure and Intelligent Biosystems. In connection with the integration of the acquired companies, we aim to improve efficiency in general and administrative operations. As we further integrate the acquired companies and pursue other opportunities to gain efficiencies, we expect to continue to ~~evaluate the potential impact at the present~~incur additional business integration and restructuring costs in 2013. Over time, we ~~expect~~believe the integration and restructuring activities will reduce general and administrative expenses as we improve efficiency in general and administrative operations.

Acquisition-Related Intangible Amortization

Amortization expense related to developed technology and patent and license rights acquired in a ~~net positive impact from~~business combination is included in cost of sales. Amortization of trademarks and customer base acquired in a business combination is recorded in operating expense under the ~~Acts effective 2013 due~~caption “acquisition-related intangible amortization.” Amortization expenses of intangible assets not acquired in a business combination are recorded within cost of sales, research and development, or sales and marketing line items based on the use of the asset.

During 2012, amortization expense on acquisition-related intangibles within operating expense increased to ~~the expected~~$36.1 million, compared to $26.7 million in 2011. The increase in ~~net sales resulting from increased healthcare coverage, which will be~~expense is the result of an increase in amortized intangibles acquired in our recent business combinations. We expect acquisition-related intangible amortization to continue to increase as a result of our acquisitions.

Other Income (Expense)

Other expense was $24.7 million in 2012, compared to $3.4 million in 2011. The increase in total other expense in 2012 was primarily the result of higher foreign currency losses and decreased interest income partially offset by lower interest expense and higher income from equity method investees.

For the ~~excise tax.~~year ended December 31, 2012, interest income decreased to $2.4 million from $6.1 million in 2011. The decrease in interest income was primarily due to lower short-term investment balances during the first half of 2012.

Interest expense decreased to $23.5 million in 2012, compared to $25.4 million in 2011. Interest costs primarily relate to debt, discussed in Note 15 in the accompanying notes to the consolidated financial statements. The decrease in interest expense is primarily due to a lower average outstanding debt balance following repayments of $469.9 million in 2011.

For the year ended December 31, 2012, foreign currency losses of $7.2 million were realized compared to a gain of $12.4 million in 2011. The currency gain in 2011 includes a favorable currency fluctuation in related to the funding of the Cellestis acquisition.

Provision for Income Taxes

In 2012 and 2011, our effective tax rates were 11% and 1%, respectively. Our operating subsidiaries are exposed to effective tax rates ranging from zero up to more than 40%. Fluctuations in the distribution of pre-tax income among our operating subsidiaries can lead to fluctuations of the effective tax rate in the consolidated financial statements. Our effective tax rate in 2012 reflects the impacts of business and financing restructurings implemented during 2011 and 2012. The effective tax rate for 2011 includes the effect of restructuring costs related to our transformation project, including impairments that lowered the mix of earnings in our higher taxing jurisdictions.

Year Ended December 31, 2011, Compared to 2010

Net Sales

In 2011, net sales increased 8% to $1,169.7 million compared to $1,087.4 million in 2010. This increase in net sales reflected a positive impact of 4% from foreign exchange rates, an organic sales increase of 2% and sales from our recently acquired businesses of 2%. In 2011, consumable and related revenues, which represent approximately 87% of total sales, increased 8% as compared to 2010. Sales of instrumentation products, which represent 13% of net sales, increased 5% in 2011. QIAsymphony placements contributed to growth in cash sales and to growing pro-rata contributions under multiyear reagent rental agreements implemented since the launch of the full QIAsymphony RGQ system in late 2010.

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In Molecular Diagnostics, which represents approximately 47% of net sales, we achieved an increase of 9% in 2011 compared to 2010. In 2011, healthcare-related sales advanced based on the global rollout of the QIAsymphony automation platform and increasing use of our companion diagnostics portfolio in Europe and other markets outside the U.S. Personalized Healthcare revenues also benefited from milestone payments for co-development projects with pharmaceutical companies. Global HPV (human papillomavirus) test sales were slightly lower in 2011, due mainly to the decline in U.S. sales linked to reduced demand for tests amid ongoing challenging economic conditions. Net sales in 2011 also included first-time contributions from Cellestis and Ipsogen, both of which were acquired in the second half of 2011.

In Applied Testing, which represents approximately 7% of net sales, we achieved 4% growth in 2011 compared to 2010, primarily as a result of higher instrumentation sales. Consumable sales of human identification and forensics products increased, benefitting from new European standards. Applied Testing also saw contributions from new veterinary testing and food safety products.

In Pharma, which represents approximately 20% of net sales, we experienced 7% growth in 2011 compared to 2010, led by a demand for products used in oncology research as well as the GeneGlobe portfolio. Also contributing to the growth was ongoing expansion of Certal products used on QIAsymphony for quality control in biopharmaceutical processing.

In Academia, which represents approximately 26% of net sales, we experienced 7% growth in 2011 compared to 2010, reflecting increased sales in consumable and instrumentation products following the success of targeted growth initiatives, primarily in Europe and Asia/Pacific. The Americas delivered flat sales amid ongoing budget uncertainty and cautious spending.

A significant portion of our revenues is denominated in euros and currencies other than the United States dollar. Changes in currency exchange rates can affect net sales, potentially to a significant degree. Net sales were positively impacted by $33.9 million in currency exchange movements for 2011 as compared to 2010.

Gross Profit

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Gross profit was $749.8 million, or 64% of net sales, in 2011, compared to $715.6 million, or 66% of net sales, in 2010. The decline in gross margin was due to several factors. Generally, our consumable sample and assay products have a higher gross margin than our instrumentation products and service arrangements. Fluctuations in the sales levels of these products and services can result in fluctuations in gross margin between periods. An increase in milestone payments from companion diagnostic co-development arrangements in 2011 negatively affected the margin since the gross margin on these services is significantly below the margin on product sales. In addition, the QuantiFERON TB product acquired with the Cellestis acquisition in 2011 carries a lower gross margin. Gross margin also was negatively impacted by 2011 costs related to the relocation of production facilities, including moving into newly constructed production space in Hilden, Germany. Additionally, gross margin in 2011 reflects costs incurred following the Japanese earthquake and other natural disasters in the first half of 2011, as well as costs related to the restructuring announced late in 2011.

Amortization expense related to developed technology and patent and license rights acquired in a business combination is included in cost of sales. The amortization expense on acquisition-related intangibles within cost of sales increased to $70.2 million in 2011 from $61.8 million in 2010, as a result of an increase in intangibles acquired in recent business combinations. We expect our acquisition-related intangible amortization to continue to increase as a result of acquisitions.

In addition, during 2011, a total of $9.6 million was expensed to acquisition and restructuring-related cost of sales in connection with the relocation of production facilities as well as the write-up of acquired inventory to fair market value as a result of business combinations. In accordance with purchase accounting rules, acquired inventory was written up to fair market value and subsequently expensed as the inventory was sold. In 2010, this expense was $1.3 million.

Research and Development

Research and development expenses increased by 4% to $130.6 million (11% of net sales) in 2011, compared to $126.0 million (12% of net sales) in 2010. The increase in research and development expense was positively affected by $5.5 million of currency exchange impact in 2011. Our business combinations, along with the acquisition of new technologies, have resulted in an increase in research and development costs. As we continue to discover, develop and acquire new products and technologies, we expect to incur additional expenses related to facilities, licenses and employees engaged in research and development efforts. Additionally, research and development costs are expected to increase as a result of seeking regulatory approvals, including U.S. FDA Pre-Market Approval (PMA), U.S. FDA 510(k) clearance and EU CE approval of certain assays or instruments. We have a strong commitment to innovation and expect to continue to make investments in our research and development efforts.

Sales and Marketing

Sales and marketing expenses increased 15% to $307.3 million (26% of net sales) in 2011 from $267.5 million (25% of net sales) in 2010. The increase in sales and marketing expenses reflects the acquisitions in 2011 along with increased sales and marketing investments to globalize the newly acquired Cellestis and Ipsogen product portfolios, as well as our investment in new sales subsidiaries in India and Taiwan. The increase also includes $11.3 million of currency exchange impact in 2011.

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Sales and marketing expenses are primarily associated with personnel, commissions, advertising, trade shows, publications, freight and logistics expenses and other promotional expenses. In addition, the sales and marketing expenses include the costs of maintaining separate sales organizations addressing customers in Molecular Diagnostics, Applied Testing, Pharma and Academia. We anticipate that sales and marketing costs will continue to increase along with new product introductions and growth in sales of our products, but we expect sales and marketing costs will grow at a relatively slower rate than our overall revenue growth over the long term.

General and Administrative, Integration and Other

General and administrative, business integration, restructuring and related costs increased by 69% to $185.5 million (16% of net sales) in 2011 from $110.0 million (10% of net sales) in 2010. The net increase iswas due primarily to $72.4 million in restructuring costs in 2011 related to internal restructuring of subsidiaries, including severance and retention costs, plus increased costs in connection with our 2011 acquisitions, partially offset by operational efficiencies. The restructuring costs primarily relate to a project we began in late 2011 to enhance productivity by streamlining the organization and freeing up resources for reallocation to strategic initiatives to help drive growth and innovation, strengthen our industry leadership position and improve longer-term profitability. This project aims to eliminate organizational layers and overlapping structures, actions that will enhance our processes, speed and productivity. Additionally, general and administrative, integration and related costs increased by $3.8 million due to currency impact in 2011, compared to the same period of 2010. During 2011, we incurred acquisition costs of approximately $13.9 million, primarily in connection with the acquisitions of Cellestis and Ipsogen. We have continued to incur integration costs for businesses acquired, totaling approximately $6.2 million in 2011, compared to $10.1 million in 2010. In connection with the integration of the acquired companies, we aim to improve efficiency in general and administrative operations. As we further integrate the acquired companies and pursue other opportunities to gain

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efficiencies, we expect to continue to incur additional business integration and restructuring costs in 2012. Over time, we believe the integration and restructuring activities will reduce general and administrative expenses as we improve efficiency in general and administrative operations.

Acquisition-Related Intangible Amortization

Amortization expense related to developed technology and patent and license rights acquired in a business combination is included in cost of sales. Amortization of trademarks, customer base and noncompete agreements acquired in a business combination is recorded in operating expense under the caption “acquisition-related intangible amortization.” Amortization expenses of intangible assets not acquired in a business combination are recorded within cost of sales, research and development, or sales and marketing line items based on the use of the asset.

During 2011, amortization expense on acquisition-related intangibles within operating expense increased to $26.7 million, compared to $23.5 million in 2010. The increase in expense iswas the result of an increase in amortized intangibles acquired in our recent business combinations. ~~We expect acquisition-related intangible amortization to continue to increase as a result of our acquisitions.~~

Other Income (Expense)

Other expense was $3.4 million in 2011, compared to $15.4 million in 2010. The decrease in total other expense in 2011 was primarily the result of increased interest income, lower interest expense and higher foreign currency gains, partially offset by lower income from equity method investees.

Interest expense decreased to $25.4 million in 2011, compared to $27.8 million in 2010. Interest costs primarily relate to long-term debt, discussed in Note 1615 in the accompanying notes to the consolidated financial statements. The decrease in interest expense is primarily due to a lower outstanding debt balance following repayments of $469.9 million in 2011.

For the year ended December 31, 2011, interest income increased to $6.1 million from $4.5 million in 2010. The increase in interest income was primarily due to higher short-term investments during the first half of 2011.

For the year ended December 31, 2011, gains on foreign currency transactions increased to $12.4 million from $2.6 million in 2010, primarily as a result of favorable currency fluctuations while funding the Cellestis acquisition.

Provision for Income Taxes

In 2011 and 2010, our effective tax rates were ~~1.3%~~1% and 17%, respectively. Our operating subsidiaries are exposed to effective tax rates ranging from zero up to more than 40%. Fluctuations in the distribution of pre-tax income among our operating subsidiaries can lead to fluctuations of the effective tax rate in the consolidated financial statements. The effective rate for 2011 was impacted by restructuring charges, including impairments, that lowered the mix of earnings in our higher taxing jurisdictions. In addition, we realized a full-year benefit of the tax planning implemented in 2010, as well as a partial benefit recognized from additional tax planning where implementation began late in 2011.

~~Year Ended December 31, 2010, Compared to 2009~~

~~Net Sales~~

~~In 2010, net sales increased 8% to~~ ~~$1,087.4 million~~ ~~compared to~~ ~~$1,009.8 million~~ in 2009. The increase in net sales includes organic growth (4%) and sales from our recently acquired businesses (4%). Our 2010 and 2009 net sales include the results of operations for, as well as the effects of the acquisitions of DxS Ltd, acquired in September 2009, and SABiosciences, acquired in December 2009.

The increase in sales was the result of growth for consumable products, which represented approximately 86% of total sales and included product, service, and license and technology sales including revenues from nonmonetary exchanges; and for instrumentation products, which represented approximately 14% of total sales. Sales of sample and assay technologies, which include consumables and instrumentation, experienced growth rates of 8% and 7%, respectively, in 2010 compared to 2009.

The net sales growth was spread across all customer classes. In Molecular Diagnostics, which represents approximately 47% of our net sales, we achieved 8% growth in 2010 compared to 2009. In 2010, we experienced lower growth in sales volumes of Molecular Diagnostics assays than in periods prior to 2010 as a result of decreasing patient visits to healthcare providers. In Applied Testing, which represents approximately 6% of our net sales, we achieved 15% growth in 2010 compared to 2009. In Pharma, which represents approximately 21% of our net sales, we experienced 6% growth in 2010 compared to 2009. In Academia, which represents approximately 26% of our net sales, we experienced 8% growth in 2010 compared to

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2009, in part due to increased purchases using stimulus funding as provided for under the American Recovery and Reinvestment Act (stimulus). In 2009, we experienced higher sales volumes of certain swine flu-related products, which were not repeated in 2010, significantly impacting growth rates in Molecular Diagnostics and Academia.

We expect further growth building upon the introduction of new consumable products and instrumentation, including the QIAensemble and QIAsymphony platforms. We continually introduce new products to extend the life of our existing product lines as well as to address new market opportunities. In 2010, we launched 86 new products in the area of sample and assay technologies.

A significant portion of our revenues is denominated in euros and currencies other than the United States dollar. Changes in currency exchange rates can affect net sales, potentially to a significant degree. Net sales were positively impacted by $0.2 million in currency exchange effects for 2010 as compared to 2009.

~~Gross Profit~~

Gross profit was $715.6 million, or 66% of net sales, in 2010, compared to $667.1 million, or 66% of net sales, in 2009. The dollar increase in 2010 compared to 2009 is attributable to the increase in net sales. Our consumable sample and assay products have a higher gross margin than our instrumentation products, and fluctuations in the sales levels of these products can result in fluctuations in gross margin between periods.

In addition, during 2010, a total of $1.3 million was expensed to acquisition-related cost of sales in connection with the write-off of inventories made obsolete following an acquisition as well as the write-up of acquired inventory to fair market value as a result of business combinations. In 2009, this expense was $7.4 million. In accordance with purchase accounting rules, acquired inventory was written up to fair market value and subsequently expensed as the inventory was sold. Additionally, in 2009, we recognized a charge of $2.5 million to cost of sales related to the impairment of developed technology, which was triggered by the acquisition of DxS and the discontinuation of certain products.

~~Research and Development~~

Research and development expenses increased 17% to $126.0 million (12% of net sales) in 2010, compared to $107.9 million (11% of net sales) in 2009. Our business combinations, along with the acquisition of new technologies, resulted in an increase in research and development costs. As we continue to discover, develop and acquire new products and technologies, we expect to incur additional expenses related to facilities, licenses and employees engaged in research and development efforts. Additionally, research and development costs are expected to increase as a result of seeking regulatory approvals, including U.S. FDA Pre-Market Approval (PMA), U.S. FDA 510(k) clearance and EU CE approval of certain assays or instruments. The increase in research and development expense was positively affected by $1.8 million of currency exchange impact in 2010.

~~Sales and Marketing~~

Sales and marketing expenses increased 9% to $267.5 million (25% of net sales) in 2010 from $244.8 million (24% of net sales) in 2009. Sales and marketing expenses are primarily associated with personnel, commissions, advertising, trade shows, publications, freight and logistics expenses and other promotional expenses. The increase in sales and marketing expenses in 2010, was primarily due to our acquisitions of DxS in September 2009 and SABiosciences in December 2009. In addition, sales and marketing expenses include the costs of maintaining separate sales organizations addressing customers Molecular Diagnostics, Applied Testing, Pharma and Academic research. The increase in sales and marketing expense was positively affected by $0.4 million of currency exchange impact in 2010.

~~General and Administrative, Integration and Other~~

General and administrative, business integration, restructuring and related costs decreased by 5% to $110.0 million (10% of net sales) in 2010 from $115.9 million (11% of net sales) in 2009. The decrease was primarily the result of lower integration costs, partially offset by increased general and administrative expenses related to new businesses acquired in 2009 and restructuring efforts in 2010. We have continued to incur integration costs for businesses acquired, totaling approximately $10.1 million in 2010, compared to $21.5 million in 2009. In 2010, we incurred $7.4 million in restructuring costs related to internal restructuring of subsidiaries, including severance and retention costs. In connection with the integration of the acquired companies, we aim to improve efficiency in general and administrative operations. Additionally, general and administrative,

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~~integration and related costs decreased by $0.7 million due to currency exchange impact in 2010, compared to 2009.~~

~~Acquisition-Related Intangible Amortization~~

During 2010, the amortization expense on acquisition-related intangibles within operating expense increased to $23.5 million, compared to $18.2 million in 2009, as a result of our recent business combinations.

~~Other Income (Expense)~~

Other expense was $15.4 million in 2010, compared to $7.9 million in 2009, primarily due to the 2009 gain from the sale of a cost-method investment and the impairment of a cost-method investment. During 2009, we sold our investment in a privately held company and realized a gain of $10.5 million. In 2010, total other expense is primarily the result of interest expense, partially offset by interest income, foreign currency gains and income from equity method investees.

Interest expense decreased to $27.8 million in 2010, compared to $29.6 million in 2009. Interest costs primarily relate to long-term debt discussed in Note 16 in the accompanying notes to the consolidated financial statements. The decrease in interest expense is primarily a result of a lower debt balance following a $50.0 million repayment, as well as decreasing interest rates.

~~For the year ended December 31, 2010, interest income increased to $4.5 million from $3.5 million in 2009. The increase in interest income was primarily due to an increase in short-term investments.~~

~~Provision for Income Taxes~~

Fluctuations in the distribution of pre-tax income among our operating subsidiaries can lead to fluctuations of the effective tax rate in the consolidated financial statements. Our operating subsidiaries are exposed to effective tax rates ranging from zero up to approximately 42%.

In 2010 and 2009, our effective tax rates were 17% and 20%, respectively. The effective rate for 2010 is impacted by a higher percentage of pre-tax book income earned in the U.S. and partially offset by the substantial impact of discrete events of (8.4%) for 2010. In 2010, as a result of internal restructuring related to the foreign subsidiaries of the former Digene Corporation, a one-time deduction for bad debt and worthless stock was realized, resulting in a $12.0 million tax benefit.

Foreign Currencies

QIAGEN N.V.’s reporting currency is the U.S. dollar, and most of our subsidiaries’ functional currencies are the local currencies of the countries in which they are headquartered. All amounts in the financial statements of entities whose functional

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currency is not the U.S. dollar are translated into U.S. dollar equivalents at exchange rates as follows: (1) assets and liabilities at period-end rates, (2) income statement accounts at average exchange rates for the period, and (3) components of shareholders’ equity at historical rates. Translation gains or losses are recorded in shareholders’ equity, and transaction gains and losses are reflected in net income. The net (loss) gain ~~(loss)~~ on foreign currency transactions in 2012, 2011 ~~2010~~ and ~~2009~~2010 was ~~$12.4~~$(7.2) million ~~$2.6~~, $12.4 million, and ~~$5.6~~$2.6 million, respectively, and is included in other income (expense), net.

Derivatives and Hedging

In the ordinary course of business, we use derivative instruments, including swaps, forwards and/or options, to manage potential losses from foreign currency exposures and variable-rate debt. The principal objective of such derivative instruments is to minimize the risks and/or costs associated with global financial and operating activities. We do not utilize derivative or other financial instruments for trading or other speculative purposes. All derivatives are recognized as either assets or liabilities in the balance sheet and are measured at fair value with any change in fair value recognized in earnings in the period of change, unless the derivative qualifies as an effective hedge that offsets certain exposures. In determining fair value, we consider both the counterparty credit risk and our own creditworthiness. To determine our own credit risk we estimate our own credit rating by benchmarking the price of our outstanding debt to publicly available comparable data from rated companies. Using the estimated rating, we quantify our credit risk by reference to publicly traded debt with a corresponding rating.

Foreign Currency Derivatives. As a globally active enterprise, we are subject to risks associated with fluctuations in

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foreign currencies in our ordinary operations. This includes foreign currency-denominated receivables, payables, debt and other balance sheet positions, including intercompany items. We manage our balance sheet exposure on a group-wide basis primarily using foreign exchange forward contracts.

Interest Rate Derivatives. We have used interest rate derivative contracts on certain borrowing transactions to hedge fluctuating interest rates. We entered into interest rate swaps in which we agreed to exchange, at specified intervals, the difference between fixed and floating interest amounts calculated by reference to an agreed-upon notional principal amount. The interest swaps matured in 2011.

We make use of ‘economic hedges’—i.e., derivatives that do not have a formally designated hedging relationship—as well as ‘accounting hedges.’ All derivatives that qualify for hedge accounting are ‘cash-flow hedges.’ Further details of our derivative and hedging activities can be found in Note 713 to the accompanying consolidated financial statements.

Liquidity and Capital Resources

To date, we have funded our business primarily through internally generated funds, debt, and private and public sales of equity. Our primary use of cash has been to support continuing operations and our capital expenditure requirements including construction of new facilities and acquisitions. As of December 31, ~~2011~~2012 and ~~2010~~2011, we had cash and cash equivalents of $~~221.1~~394.0 million and $~~828.4~~221.1 million, respectively. We also had short-term investments of $~~54.6~~90.5 million at December 31, ~~2011~~2012. Cash and cash equivalents are primarily held in U.S. dollars and euros, other than those cash balances maintained in the local currency of subsidiaries to meet local working capital needs. At December 31, ~~2011~~2012, cash and cash equivalents had ~~decreased~~increased by ~~$607.3~~$172.9 million from December 31, ~~2010~~2011, primarily ~~due to~~as a result of cash provided by operating activities of $244.9 million and financing activities of $226.6 million partially offset by cash used in investing activities of $~~540.3 million~~ ~~and cash used in financing activities of~~ ~~$310.6 million~~ ~~partially offset by cash provided by operating activities of~~ ~~$244.8~~300.9 million. As of December 31, ~~2011~~2012 and ~~2010~~2011, we had working capital of ~~$266.8~~$725.8 million and ~~$976.2~~$293.8 million, respectively.

Operating Activities. For the years ended December 31, ~~2011~~2012 and ~~2010~~2011, we generated net cash from operating activities of $~~244.8~~244.9 million and $~~250.8~~244.8 million, respectively. While net income of ~~$94.9~~$129.5 million in ~~2011 decreased~~2012 increased by ~~$49.3~~$34.6 million as compared to the prior year, ~~the~~2011 net income was reduced by restructuring accruals which were mostly paid out in 2012. The non-cash components such as depreciation and amortization, share-based compensation, deferred income taxes and other non-cash activity including restructuring measures increased cash from operating activities by ~~$210.4~~$199.2 million as of December 31, ~~2011~~2012. This increase was partially offset by net changes in operating assets and liabilities of ~~$42.9~~$83.9 million, primarily due to an increase in inventories, accounts receivable and ~~accounts receivable. In 2011, inventories increased primarily due to increased safety stock in connection with the transfer of production activities to a new production facility in Germany.~~income taxes. Because we rely heavily on cash generated from operating activities to fund our business, a decrease in demand for our products, longer collection cycles or significant technological advances of competitors would have a negative impact on our liquidity.

Investing Activities. Approximately $~~540.3~~300.9 million of cash was used in investing activities during ~~2011,~~2012, compared to $~~215.5~~540.3 million during ~~2010~~2011. Investing activities during ~~2011~~2012 consisted principally of $~~186.8~~39.9 million invested in short-term investments, $~~86.8~~102.0 million in cash paid for purchases of property and equipment, primarily in our ongoing construction projects in ~~Germany and~~ the U.S., as well as $~~34.6~~26.1 million paid for intangible assets. Cash paid for acquisitions, net of cash acquired, of $~~457.5~~132.0 million was used primarily in the acquisitions of ~~Cellestis~~AmniSure and ~~Ipsogen~~Intelligent Biosystems and includes ~~$3.1~~$1.1 million of cash paid in connection with acquisition milestone achievements. As of December 31, ~~2011~~2012, we also ~~acquired a stake in Alacris for $3.4 million and~~had made an ~~investment~~investments of ~~$16.4~~

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$8.2 million in ~~another~~ privately held ~~company.~~companies. These investing activities were partially offset by $~~242.6~~6.0 million from the sale of short-term investments.

In 2009, we purchased the land and building adjacent to our facility in Hilden, Germany for ~~EUR 2.5~~€2.5 million (approximately $3.2 million) to further expand our German facilities for research and development and production. In addition, we started the expansion of our Germantown, Maryland, USA facility for production and administrative space in June 2010. While the construction in Germany is ~~substantially~~ complete, the U.S. expansion projects are expected to continue into ~~2014,~~2013, with both projects at an estimated total cost of approximately $94.0 million. We anticipate that we will be able to fund these expansions with cash generated by operating activities.

In connection with certain acquisitions, we could be required to make additional contingent cash payments totaling up to $~~103.1~~134.2 million based on the achievement of certain revenue and operating results milestones as follows: $~~26.5 million~~ ~~in 2012,~~ ~~$11.1~~18.9 million in 2013, $~~12.3~~23.4 million in 2014, $~~4.7~~16.3 million in 2015, $~~6.4~~17.5 million in 2016, $7.0 million in 2017 and $~~42.1~~51.1 million payable in any 12-month period from now until ~~2016~~2017 based on the accomplishment of certain revenue targets, the launch of certain products or the grant of certain patent rights. Of the $~~103.1~~134.2 million total contingent obligation, approximately $~~39.8~~19.0 million is accrued as of December 31, ~~2011~~2012.

Financing Activities. Financing activities ~~used $310.6~~provided $226.6 million in cash for the year ended December 31, ~~2011~~2012 compared to ~~$35.2~~a use of $310.6 million for ~~2010~~2011. Cash ~~used~~provided during ~~2011~~2012 was primarily ~~related~~due to ~~the repayment of long-term of~~new debt of ~~$469.9~~$400.0 million

~~Table~~ issued in a private placement of ~~Contents~~

~~partially offset by proceeds~~new senior unsecured notes. The new borrowings were used in part to repay $143.3 million of ~~short-term and long-term debt of $142.3 million and $44.0 million respectively.~~short term debt. Also in ~~2011, $29.8~~2012, we commenced a share buyback and as of December 31, 2012 had repurchased 1.9 million ~~was used to purchase additional~~common shares at a total price of ~~Ipsogen's noncontrolling interest and other~~approximately $35.7 million. Other cash payments of ~~$7.6~~$6.0 million were related to milestone payments from previous acquisitions. Cash used during 2010 was primarily due to the repayment of $50.0 million of long-term debt and capital lease payments, partially offset by proceeds from debt as well as cash provided by the issuance of common shares in connection with our equity compensation plans and tax benefits from stock-based compensation.

In December 2011, we entered into a €400.0 million syndicated multi-currency revolving credit facility expiring December 2016 of which ~~€110.0 million (approximately $142.3 million) was~~no amounts were utilized at December 31, ~~2011 and is due in~~ 2012. We have additional credit lines totaling ~~$8.6~~€38.0 million ~~at variable interest rates,~~with no expiration date, none of which was utilized as of December 31, ~~2011~~2012. We also have capital lease obligations, including interest, in the aggregate amount of ~~$23.5~~$22.8 million, and carry ~~$447.6~~$847.0 million of long-term debt, of which ~~$1.6~~$0.9 million is current as of December 31, ~~2011~~2012. ~~As of~~ ~~December 31, 2011, we have drawn down EUR 1.6 million under a loan to finance research and development projects in Germany. The loan bears interest at 3.5% and is due to be fully repaid by 2013.~~

In July 2007, we signed a Syndicated Multi-Currency Term Loan and Revolving Credit Facilities Agreement with Deutsche Bank AG, Deutsche Bank Luxembourg S.A., and the lenders named in the syndication agreement. We used the proceeds of the term loan and the bridge loan to pay the cash component of the Digene acquisition consideration and the fees and expenses of the Digene offer and the merger. During 2011, we repaid the debt in full.

We have notes payable, which are the long-term borrowings of the proceeds from the issuances of $150.0 million senior unsubordinated convertible notes, with a 1.5% coupon due in 2024 through QIAGEN Finance (2004 Notes), and of $300.0 million 3.25% senior convertible notes (2006 Notes) due in 2026 through QIAGEN Euro Finance. QIAGEN Finance and Euro Finance are unconsolidated subsidiaries, which were established for this purpose. The 2004 Notes are convertible into our common shares at a conversion price of $12.6449, subject to adjustment, and the 2006 Notes are convertible into our common shares at a conversion price of $20.00, subject to adjustment. In connection with conversion of $5.0 million of the 2004 Notes, we repaid $5.0 million of the debt to QIAGEN Finance. At December 31, ~~2011~~2012, $145.0 million and $300.0 million are included in long-term debt for the amount of the notes payable to QIAGEN Finance and Euro Finance, respectively. The $145.0 million note payable has an effective rate of ~~1.84%~~1.8%, and had an original maturity in July 2011. We refinanced the $145.0 million note, which has a new maturity date of February 2024. The $300.0 million note payable has an effective rate of ~~3.97%~~3.7% and is due in ~~December 2014.~~May 2026. QIAGEN N.V. has guaranteed the 2004 and 2006 Notes and has agreements with QIAGEN Finance and Euro Finance to issue shares to the investors in the event of conversion. These subscription rights, along with the related receivable, are recorded at fair value in the equity of QIAGEN N.V. as paid-in capital.

Our Supervisory Board and shareholders granted management the discretion to repurchase up to $100 million of our common shares (excluding transaction costs). In October 2012, we commenced the buyback and as of December 31, 2012 have repurchased 1.9 million common shares at a total price of approximately $35.7 million. We expect to complete the share repurchase program during the first quarter of 2013.

We expect that cash from financing activities will continue to be impacted by issuances of our common shares in connection with our equity compensation plans and that the market performance of our stock will impact the timing and volume of the issuances. Additionally, we may make future acquisitions or investments requiring cash payments, the issuance of additional equity or debt financing.

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We believe that funds from operations, existing cash and cash equivalents, together with the proceeds from our public and private sales of equity, and availability of financing facilities, will be sufficient to fund our planned operations and expansion during the coming year. However, the global economic downturn may have a greater impact on our business than currently expected, and we may experience a decrease in the sales of our products, which could impact our ability to generate cash. The availability of debt financing has also been negatively impacted by the global credit crisis. If our future cash flows from operations and other capital resources are not adequate to fund our liquidity needs, we may be required to obtain additional debt or equity financing or to reduce or delay our capital expenditures, acquisitions or research and development projects. If we could not obtain financing on a timely basis or at satisfactory terms, or implement timely reductions in our expenditures, our business could be adversely affected.

Off-Balance Sheet Arrangements

Other than our arrangements with QIAGEN Finance and Euro Finance as discussed above and in the notes to the consolidated financial statements, we did not use special purpose entities and do not have off-balance sheet financing arrangements as of and during the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009.~~2010.

Contractual Obligations

As of December 31, ~~2011~~2012, our future contractual cash obligations, including interest, are as follows:

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Contractual obligations (in thousands)	Payments Due by Period														Payments Due by Period
Contractual obligations (in thousands)	Total		2012		2013		2014		2015		2016		Thereafter		Total		2013		2014		2015		2016		2017		Thereafter
Long-term debt	$	447,622	$	1,617	$	486	$	300,000	$	519	$	—	$	145,000	$	1,166,591	$	29,179	$	28,653	$	28,932	$	28,312	$	28,340	$	1,023,175
Capital lease obligations	23,503		4,008		4,191		4,366		4,640		3,674		2,624		22,846		5,396		5,304		5,290		3,998		1,429		1,429
Operating leases	51,948		15,879		12,067		9,316		6,905		4,763		3,018		54,454		16,309		11,389		9,834		5,879		3,234		7,809
Purchase obligations	80,738		54,686		25,556		496		—		—		—		60,369		54,754		4,124		1,339		152		—		—
License and royalty payments	9,776		1,600		1,122		1,222		1,222		1,222		3,388		21,261		9,224		3,762		1,773		1,798		1,799		2,905
Total contractual cash obligations	$	613,587	$	77,790	$	43,422	$	315,400	$	13,286	$	9,659	$	154,030	$	1,325,521	$	114,862	$	53,232	$	47,168	$	40,139	$	34,802	$	1,035,318

In addition to the above and pursuant to purchase agreements for several of our recent acquisitions, we could be required to make additional contingent cash payments totaling up to $~~103.1~~134.2 million based on the achievement of certain revenue and ~~other~~operating results milestones as follows: $18.9 millionin 2013, $23.4 million in 2014, $16.3 million in 2015, $17.5 million in 2016, $7.0 million in 2017, and $51.1 million, payable in any 12-month period from now until 2017 based on the accomplishment of certain revenue targets, the launch of certain products or the grant of certain patent rights. As of December 31, 2012, ~~and beyond.~~we have accrued $19.0 million.

Liabilities associated with uncertain tax positions, including interest and penalties, are currently estimated at ~~$7.4~~$13.8 million and are not included in the table above, as we cannot reasonably estimate when, if ever, an amount would be paid to a government agency. Ultimate settlement of these liabilities is dependent on factors outside of our control, such as examinations by each agency and expiration of statutes of limitation for assessment of additional taxes.

Critical Accounting Policies, Judgments and Estimates

The preparation of our financial statements in accordance with accounting principles generally accepted in the United States requires management to make assumptions that affect the reported amounts of assets, liabilities and disclosure of contingencies as of the date of the financial statements, as well as the reported amounts of revenues and expenses during the reporting period. Critical accounting policies are those that require the most complex or subjective judgments often as a result of the need to make estimates about the effects of matters that are inherently uncertain. Thus, to the extent that actual events differ from management’s estimates and assumptions, there could be a material impact to the financial statements. In applying our critical accounting policies, at times we used accounting estimates that either required us to make assumptions about matters that were highly uncertain at the time the estimate was made or it is reasonably likely that changes in the accounting estimate may occur from period to period that would have a material impact on the presentation of our results of operations, financial position or cash flows. Our critical accounting policies are those related to revenue recognition, share-based compensation, income taxes, investments, variable interest entities, goodwill and other intangible assets, purchase price

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allocation and fair value measurements. We reviewed the development, selection, and disclosure of our critical accounting policies and estimates with the Audit Committee of our Supervisory Board.

Revenue Recognition. We recognize revenue when four basic criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the fee is fixed or determinable; and (4) collectability is reasonably assured. Determination of criteria (3) and (4) could require management’s judgments regarding the fixed nature of the fee charged for services rendered and products delivered and the collectability of those fees. ~~Multiple-element~~While the majority of our sales agreements contain standard terms and conditions, we do enter into agreements that contain multiple elements or non-standard terms and conditions. Sometimes interpretation of the sales agreement or contract for multiple-element arrangements ~~are assessed to determine~~is complex and determining whether there is more than one unit of ~~accounting.~~accounting and if so, how and when revenue should be recognized for each element is subject to certain estimates or assumptions. We record revenue as the separate elements are delivered to the customer if the delivered item has value on a stand-alone basis and delivery or performance of the undelivered item is probable and substantially in our control. Revenue is allocated according to the relative selling price method. Should changes in conditions cause management to determine that these criteria are not met for certain future transactions, revenue recognized for any reporting period could be adversely affected.

Share-Based Compensation. Our stock plan, the QIAGEN N.V. Amended and Restated 2005 Stock Plan (the Plan), allows for the granting of stock rights, incentive stock options, as well as for non-qualified options, stock grants and stock-based awards. We use the Black-Scholes-Merton valuation model for estimating the fair value of our stock option grants. Option valuation models, including Black-Scholes-Merton, require the input of highly subjective assumptions, including the risk-free rate of interest, expected dividend yield, expected volatility, and the expected life of the award. Changes in the assumptions used can materially affect the grant date fair value of an award. For details on the assumptions and methodologies used in determining the fair value of stock options, refer to Note 1721 of the Notes to Consolidated Financial Statements.

Income Taxes. Calculation of our tax provision is complex due to our international operations and the multiple taxing jurisdictions in which we operate. Some of our deferred tax assets relate to net operating losses (NOL). The utilization of NOLs is not assured and is dependent on generating sufficient taxable income in the future. Although management believes it is

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more likely than not that we will generate sufficient taxable income to utilize substantially all NOL carryforwards, evaluating the NOLs related to our newer subsidiaries requires us to make estimates that we believe are reasonable, but may also be highly uncertain given that we do not have direct experience with these subsidiaries or their products. Thus the estimates may be subject to significant changes from period to period as we gain that experience. To the extent that our estimates of future taxable income are insufficient to utilize all available NOLs, a valuation allowance will be recorded in the provision for income taxes in the period the determination is made, and the deferred tax assets will be reduced by this amount, which could be material. In the event that actual circumstances differ from management’s estimates, or to the extent that these estimates are adjusted in the future, any changes to the valuation allowance could materially impact our financial position and results of operations.

Investments. We have equity investments accounted for under the cost method. We periodically review the carrying value of these investments for permanent impairment, considering factors such as the most recent stock transactions, book values from the most recent financial statements, and forecasts and expectations of the investee. Estimating the fair value of these nonmarketable equity investments in life science companies is inherently subjective, and if actual events differ from management’s assumptions, it could require a write-down of the investment that could materially impact our financial position and results of operations.

In addition, generally accepted accounting principles require different methods of accounting for an investment depending on the level of influence that we exert. Assessing the level of influence involves subjective judgments. If management’s assumptions with respect to its level of influence differ in future periods and we therefore have to account for these investments under a method other than the cost method, it could have a material impact to our financial statements.

Variable Interest Entities. FASB ASC Topic 810 requires a company to consolidate a variable interest entity in which it holds a variable interest if it is designated as the primary beneficiary of that entity even if the company does not have a majority of voting interests. A variable interest entity is generally defined as an entity with insufficient equity to finance its activities or where the owners of the entity lack the risk and rewards of ownership. Assessing the requirements of ASC Topic 810 involves subjective judgments. If management’s assumptions with respect to the criteria differ in future periods, and we therefore have to account for these investments under a different method, it could have a material impact on our financial statements.

Goodwill and Other Intangible Assets. We assess goodwill for impairment at least annually in the absence of an indicator of possible impairment and immediately upon an indicator of possible impairment. Goodwill is deemed to be impaired if we determine that the carrying value of our reporting unit is more than the fair value. Due to the numerous variables associated with our judgments and assumptions relating to the valuation of reporting units and the effects of changes in circumstances affecting these valuations, both the precision and reliability of the resulting estimates are subject to uncertainty. As additional

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information becomes known, we may change our estimates.

In the fourth quarter of ~~2011,~~2012, we performed our annual impairment assessment of goodwill (using data as of October 1, ~~2011)~~2012). We performed our goodwill impairment testing on a single reporting unit basis which is consistent with our reporting structure. In testing for potential impairment, we measured the estimated fair value of our business based upon discounted future operating cash flows using a discount rate reflecting our estimated average cost of funds. Differences in assumptions used in projecting future operating cash flows and cost of funds could have a significant impact on the determination of impairment amounts. In estimating future cash flows, we used our internal budgets. Our budgets were based on recent sales data for existing products, planned timing of new product launches or capital projects, and customer commitments related to new and existing products. These budgets also included assumptions of future production volumes and pricing. ~~We concluded that no impairment existed.~~ Based on the sensitivity analysis performed, we determined that in the event that our estimates of projected future cash flows were too high by 10%, there would still be no impact on the reported value of ~~goodwill~~goodwill. We concluded that no impairment existed at October 1, 2012 or through December 31, ~~2011~~2012.

Due to the numerous variables associated with our judgments and assumptions relating to the valuation of the reporting units and the effects of changes in circumstances affecting these valuations, both the precision and reliability of the resulting estimates are subject to uncertainty, and as additional information becomes known, we may change our estimates.

Purchase Price Allocation. The purchase price allocation for acquisitions requires extensive use of accounting estimates and judgments to allocate the purchase price to the identifiable tangible and intangible assets acquired, including in-process research and development, and liabilities assumed based on their respective fair values. An acquisition may include contingent consideration as part of the purchase price. Contingent consideration is accounted for at fair value at the acquisition date with subsequent changes to the fair value being recognized in earnings. Additionally, we must determine whether an acquired entity is considered to be a business or a set of net assets, because a portion of the purchase price can only be allocated to goodwill in a business combination.

We have made several acquisitions in recent years. The purchase prices for the acquisitions were allocated to tangible and intangible assets acquired and liabilities assumed based on their estimated fair values at the acquisition dates. We engaged an independent third-party valuation firm to assist us in determining the estimated fair values of in-process research and development and identifiable intangible assets. Such a valuation requires significant estimates and assumptions, including but

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not limited to determining the timing and estimated costs to complete the in-process projects, projecting regulatory approvals, estimating future cash flows, and developing appropriate discount rates. We believe the estimated fair values ~~assigned to the~~of contingent consideration and assets acquired and liabilities assumed are based on reasonable assumptions. However, the fair value estimates for the purchase price allocations may change during the allowable allocation period, which is up to one year from the acquisition dates, if additional information becomes available.

Fair Value Measurements. We have categorized our assets and liabilities that are measured at fair value, based on the priority of the inputs to the valuation techniques, in a three-level fair value hierarchy: Level 1 - using quoted prices in active markets for identical assets or liabilities; Level 2 - using observable inputs other than quoted prices; and Level 3 – using unobservable inputs. We primarily apply the market approach for recurring fair value measurements, maximize our use of observable inputs and minimize our use of unobservable inputs. We utilize the mid-point price between bid and ask prices for valuing the majority of our assets and liabilities measured and reported at fair value. In addition to using market data, we make assumptions in valuing assets and liabilities, including assumptions about risk and the risks inherent in the inputs to the valuation technique.

Certain of our derivative instruments, which are classified in Level 2 of the fair value hierarchy, are valued using industry-standard models that consider various inputs, including time value, volatility factors, and current market and contractual prices for the underlying instruments, as well as other relevant economic measures. Substantially all of these inputs are observable in the marketplace throughout the full term of the instrument, can be derived from observable data or are supported by observable prices at which transactions are executed in the marketplace.

WeCertain of our acquisitions involve contingent consideration, the payment of which is contingent on the occurrence of future events. Contingent consideration is classified in Level 3 of the fair value hierarchy and is initially recognized at fair value as a cost of the acquisition. After the acquisition, the contingent consideration liability is remeasured each reporting period. The fair value of contingent consideration is measured predominantly on unobservable inputs such as assumptions about the likelihood of achieving specified milestone criteria, projections of future financial performance, assumed discount rates and assumed weightings applied to potential scenarios in deriving a probability weighted fair value. Significant judgment is used in developing these estimates and assumptions both at the acquisition date and in subsequent periods. If actual events differ from management's estimates, or to the extent these estimates are adjusted in the future, our financial condition or results of operations could be affected in the period of any change.

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For other fair value measurements, we generally use an income approach to measure fair value when there is not a market observable price for an identical or similar asset or liability. This approach utilizes management’s best assumptions regarding expectations of projected cash flows, and discounts the expected cash flows using a commensurate risk-adjusted discount rate.

The above listing is not intended to be a comprehensive list of all our accounting policies. In many cases, the accounting treatment of a particular transaction is specifically dictated by generally accepted accounting principles in the United States, with limited or no need for management’s judgment. There are also areas in which management’s judgment in selecting available alternatives may or may not produce a materially different result. See our audited consolidated financial statements and notes thereto in Item 18 of this Annual Report, containing a description of accounting policies and other disclosures required by generally accepted accounting principles in the United States.

Recent Authoritative Pronouncements

For information on recent accounting pronouncements impacting our business see Note 2 of the Notes to Consolidated Financial Statements included in Item 18.


Item 6.	Directors, Senior Management and Employees

Managing Directors and Supervisory Directors are appointed annually for the period beginning on the date following the Annual General Meeting of our shareholders up to and including the date of the Annual General Meeting held in the following year.

Our Supervisory Directors and Managing Directors for the year ended December 31, 2012 and their ages as of January 27, ~~2012,~~2013, are as follows:

Managing Directors:



Name	Age	Position
Peer M. Schatz	46	47	Managing Director, Chief Executive Officer
Roland Sackers	43	44	Managing Director, Chief Financial Officer
Dr. Joachim Schorr⁽¹⁾	51	52	Managing Director, Senior Vice President, Research and Development
Bernd Uder⁽²⁾	54	55	Managing Director, Senior Vice President, Global Sales and Service Solutions

____________________


(1)	Dr. Joachim Schorr was a member of our Managing Board until April 30, 2012.


(2)	Bernd Uder was a member of our Managing Board until December 31, 2012.

Supervisory Directors:

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Name	Age	Position
Prof. Dr. Detlev H. Riesner	70	71	Chairman of the Supervisory Board, Supervisory Director and Chairman of the Selection and Appointment Committee
Dr. Werner Brandt	58	59	Supervisory Director and Chairman of the Audit Committee
Dr. Metin Colpan	56	57	Supervisory Director
Erik Hornnaess	74	75	Deputy Chairman of the Supervisory Board, Supervisory Director, Chairman of the Compensation Committee, Member of the Audit Committee and Member of the Selection and Appointment Committee
Prof. Dr. Manfred Karobath	70	71	Supervisory Director and Member of the Compensation Committee
Heino von Prondzynski	62	63	Supervisory Director ~~and Member of the Audit Committee~~
Elizabeth E. Tallett	62	63	Supervisory Director and Member of the Audit Committee and Member of the Compensation Committee

The following is a brief summary of the background of each of the Supervisory Directors and Managing Directors. References to “QIAGEN” and the “Company” in relation to periods prior to April 29, 1996 mean QIAGEN GmbH and its consolidated subsidiaries:

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Managing Directors

Peer M. Schatz, ~~46,~~47, joined the Company in 1993 and has been Chief Executive Officer since January 1, 2004. Between 1993 and 2003 he was Chief Financial Officer and became a member of the Managing Board in 1998. Mr. Schatz was previously a partner in a private management buyout group in Switzerland and worked in finance and systems positions in Sandoz, Ltd. and Computerland AG, as well as in finance, operations, management and sales positions in various start-up companies in the computer and software trading industry in Europe and the United States. Mr. Schatz graduated from the University of St. Gallen, Switzerland, with a Master's degree in Finance in 1989 and obtained an M.B.A. in Finance from the University of Chicago Graduate School of Business in 1991. Until 2008, Mr. Schatz was a member of the Supervisory Board of Evotec AG. ~~He serves~~Until 2011, he served as a member of the Managing Board of PMS Asset Management GmbH. Mr. Schatz also previously served as a member of the German Corporate Governance Commission from 2002 to January 2012. He is also chairman of the board of directors of Ipsogen S.A., which is a majority-owned subsidiary of QIAGEN that was acquired in 2011.

Roland Sackers, ~~43,~~44, joined the Company in 1999 as Vice President Finance and has been Chief Financial Officer since 2004. In 2006, Mr. Sackers became a member of the Managing Board. Between 1995 and 1999, he served as an auditor with Arthur Andersen Wirtschaftsprüfungsgesellschaft Steuerberatungsgesellschaft. Mr. Sackers earned his Diplom-Kaufmann from the Westfälische Wilhelms-Universität Münster, Germany after studying business administration. Until 2006, he was a member of the Supervisory Board and Audit Committee of IBS AG. Mr. Sackers was also a member of the board of directors of Operon Biotechnologies, Inc., until December 2007. Mr. Sackers is a board member of the industry association BIO Deutschland. He is also a non-executive director and chair of the audit committee of Immunodiagnostic Systems Holding (IDS), a leading producer of immunological tests for research and diagnostic applications publicly listed in the United Kingdom, as well as member of the board of directors and head of the audit committee of Ipsogen S.A., which is a majority-owned subsidiary of QIAGEN that was acquired in 2011.

Dr. Joachim Schorr, ~~51,~~52, joined the Company in 1992 and ~~has been~~was Senior Vice President Research & Development since January 1, 2004. He became a member of the Managing Board in 2004. Initially, Dr. Schorr served the Company as Project Manager and later had responsibilities as Business Unit Manager. In 1999, Dr. Schorr became Vice President Research & Development with the responsibility for the world-wide QIAGEN R&D activities. Before joining QIAGEN, Dr. Schorr worked for the pharmaceutical company Hoechst AG on the development of oral malaria vaccines and was awarded with the IHK research award in 1991. Dr. Schorr holds a Ph.D. in Molecular Biology and Virology from the University of Cologne. Dr. Schorr is a co-founder of Coley Pharmaceuticals, EnPharma Pharmaceuticals and QBM Cell Sciences and is currently a member of the Supervisory Board of QBM Cell Sciences. Dr. Schorr retired from QIAGEN on April 30, 2012.

Bernd Uder, ~~54,~~55, joined the Company in 2001 as Vice President Sales & Marketing and became a member of the Managing Board and Senior Vice President Sales & Marketing in 2004. In 2005, Mr. Uder became Senior Vice President Global Sales and Service Solutions. Before joining the Company, Mr. Uder gained wide experience in building up and coordinating world-wide distribution networks as Vice President European Biolab Sales & Marketing with Pharmacia and Vice President global e-business with Amersham Pharmacia Biotech. Mr. Uder retired from QIAGEN on December 31, 2012.

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Supervisory Directors

Professor Dr. Detlev H. Riesner, ~~70,~~71, is a co-founder of the Company. He has been a member of the Supervisory Board since 1996 and was appointed Chairman of the Supervisory Board in 1999, and in 2005, he was also appointed Chairman of the Selection and Appointment Committee. Professor Riesner has held the Chair of Biophysics at the Heinrich-Heine-University in Düsseldorf since 1980 and retired in 2006. He has held the position of Dean of the Science Faculty (1991-92), Vice President of the University (Research) (1996-99) and Director of Technology (1999-2006). In 2007, he became a member of the University's board of trustees. Prior to that, he was Professor of Biophysical Chemistry at the Darmstadt Institute of Technology and, from 1975 to 1977, Lecturer of Biophysical Chemistry at Hannover Medical School. He has held guest professorships at the Institute of Microbiology, Academia Sinica, Beijing, and the Department of Neurology at the University of California, San Francisco. He received his M.S. in Physics from Hannover Institute of Technology and his Ph.D. from the University of Braunschweig, with post-graduate work at Princeton University. Professor Riesner is either a member of the Supervisory Board or a director of AC Immune S.A., Lausanne, ~~Algiax Pharmaceuticals GmbH (former Spinal Cord Therapeutics), Erkrath,~~ Evocatal GmbH, Düsseldorf, DRK Blutspendedienst West gGmbH, Hagen and DIWA GmbH, ~~Dusseldorf.~~Düsseldorf. His memberships in the advisory boards of NewLab Bioquality AG and Direvo AG ended in 2006 and SCT GmbH ended in 2011, when the companies were ~~sold in 2006.~~sold. Professor Riesner is also a member of the scientific advisory ~~boards~~board of ~~PrioNet, Canada, and~~ Alberta Prion Research Institute, Canada.

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Dr. Werner Brandt, ~~58,~~59, joined the Company's Supervisory Board in 2007. In the same year, he was appointed Chairman of the Audit Committee. Dr. Brandt has been a member of the Executive Board and the Chief Financial Officer of SAP AG since 2001. From 1999 to 2001, he was a member of the Executive Board and Chief Financial Officer of the German-American healthcare company, Fresenius Medical Care AG, where he also served as Labor Relations Director. From 1992 to 1999, Dr. Brandt was a member of the Managing Board of Baxter Deutschland GmbH and Vice President for European Operations. In this capacity, he was responsible for Baxter's financial operations in Europe. Dr. Brandt began his career in 1981 at the former Price Waterhouse GmbH (now PricewaterhouseCoopers) in Frankfurt. Dr. Brandt completed his Doctorate in business administration from the Technical University of Darmstadt, Germany in 1991, after studying business administration at the University of Nuremberg-Erlangen, Germany from 1976 to 1981. Dr. Brandt is currently a member of the Supervisory ~~Boards~~Board of Deutsche Lufthansa AG.

Dr. Metin Colpan, ~~56,~~57, is a co-founder of the Company and was Chief Executive Officer and a Managing Director from 1985 through 2003. Dr. Colpan has been a member of the Supervisory Board since 2004. Dr. Colpan obtained his Ph.D. and M.S. in Organic Chemistry and Chemical Engineering from the Darmstadt Institute of Technology in 1983. Prior to founding QIAGEN, Dr. Colpan was an Assistant Investigator at the Institute for Biophysics at the University of Düsseldorf. Dr. Colpan has had wide experience in separation techniques, and in the separation and purification of nucleic acids in particular, and has filed many patents in the field. Dr. Colpan currently serves as a Supervisory Board member of Morphosys AG, Munich, Germany and Qalovis Farmer Automatic Energy GmbH, Laer, Germany. Dr. Colpan previously served as Supervisory Board member of Ingenium Pharmaceuticals AG, GenPat77 Pharmacogenetics AG and GPC Biotech AG, each in Munich, Germany.

Erik Hornnaess, ~~74,~~75, has been a member of the Supervisory Board since 1998. He joined the Audit Committee in 2002, the Compensation Committee in 2005 and the Selection and Appointment Committee in 2007. He was appointed Deputy Chairman of the Supervisory Board in 2007. Mr. Hornnaess worked for Astra Pharmaceuticals, Sweden from 1965 until 1979 in various management positions in Sweden, Australia, and Canada and, for the last three years of this period, as the General Manager for the Benelux region (Belgium, The Netherlands and Luxembourg). In 1979, he joined Abbott Laboratories European Headquarters in Paris, France, and from 1982, he was the Area Vice-President of Abbott Diagnostic Division in Europe, Middle-East and Africa, with headquarters in Wiesbaden, Germany. Mr. Hornnaess retired from Abbott Laboratories on March 1, 1997. Additionally, Mr. Hornnaess served as the Vice-President of European Diagnostic Manufacturers Association (EDMA), Brussels in the period 1995 through 1997. Mr. Hornnaess graduated from Aarhus Handelshojskole, Denmark with an M.B.A. and obtained a P.M.D. from the Harvard Business School.

Professor Dr. Manfred Karobath, ~~70,~~71, has been a member of the Supervisory Board since 2000 and joined the Compensation Committee in 2005. Prof. Dr. Karobath studied medicine, and from 1967 to 1980, he worked first in the Dept. of Biochemistry of the University of Vienna and, after a stage as postdoctoral fellow, he joined the Dept. of Psychiatry where he became Professor of Biological Psychiatry. In 1980, he joined Sandoz Pharma in Basel, first, in drug discovery, and later, he became Senior Vice President and head of R&D. In 1992, Prof. Dr. Karobath joined Rhone Poulenc Rorer (“RPR”) as President of R&D and Executive Vice President, and later, he became a member of the boards of directors of RPR, Pasteur Mérieux Connought, Centeon and Rhone Poulenc Pharma. He has received several scientific awards and has published 92 scientific papers.

Heino von Prondzynski, ~~62,~~63, joined the Company's Supervisory Board as well as the Audit Committee in 2007. Mr. von Prondzynski retired in 2005 from Roche where he served as Chief Executive Officer of Roche Diagnostics and a member of the Executive Committee of the Roche Group. Prior to joining Roche in 2000, Mr. von Prondzynski worked at Chiron, first as

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General Manager and Chief Executive Officer in Germany and Italy, later as President of the Vaccines Division in Emeryville, USA. Mr. von Prondzynski started his career with Bayer in Germany as a sales representative and later worked in Austria and Brazil as General Manager. He studied mathematics, geography and history at Westfälische Wilhelms University of Münster in Germany. Mr. von Prondzynski is a director of Koninklijke Philips Electronics NV, Hospira, Inc., HTL Strefa and ~~Hospira, Inc and Chairman of Biocare Holding AG and HTL Strefa.~~Epigenomics AG. Mr. von Prondzynski was previously ~~a director of Epigenomics AG and~~ Chairman of Nobel Biocare Holding AG.

Elizabeth E. Tallett, ~~62,~~63, joined the Company's Supervisory Board as well as the Audit Committee and Compensation Committee in 2011. Ms. Tallett has been a Principal of Hunter Partners, LLC, a management company for early to mid-stage pharmaceutical, biotechnology and medical device companies, since 2002. Her senior management experience includes President and CEO of Transcell Technologies Inc., President of Centocor Pharmaceuticals, member of the Parke-Davis Executive Committee, and Director of Worldwide Strategic Planning for Warner-Lambert Company. Ms. Tallett graduated from Nottingham University, England with dual Bachelor's degrees with honors in mathematics and economics. She is a member of the board of directors of Principal Financial Group, Inc., Coventry Health Care, Inc., and Meredith Corp. ~~and IntegraMed America, Inc.~~ Ms. Tallett is currently the Lead Director for both Principal and Coventry Health Care. She was also a director of Varian, Inc., Immunicon, Inc. ~~and~~, Varian Semiconductor Equipment Associates, Inc. and IntegraMed America, Inc. at times during the past five years. Ms. Tallett was a founding board member of the Biotechnology Council of New Jersey and is a Trustee of Solebury School in Pennsylvania.

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Compensation of Directors and Officers

Compensation policy

Since the creation of QIAGEN, management has formed a culture that seeks to attract and retain the best talent worldwide and reward associates for their performance. This compensation system aims to foster focus on achieving corporate strategic initiatives as well as personal accountability.

It is critical for QIAGEN to offer attractive compensation packages on a global basis. According to the QIAGEN philosophy, an employee who achieves their performance objectives should generally be awarded compensation comparable to the medial levels of compensation provided by relevant benchmark companies. In case of over or under performance, the actual total compensation may significantly differ from the benchmark median. QIAGEN participates in various compensation benchmarking surveys that provide information on the level, as well as the mix, of compensation awarded by various companies and industries for a broad range of positions around the world. In the case of QIAGEN, these include many peer life science and diagnostic companies based in the U.S.

QIAGEN has a “pay for performance” culture, with the compensation of employees linked to the achievement of business and individual performance goals. Business goals are established by the Executive Committee each year, and approved by the Compensation Committee. These goals are set at ambitious levels each year to motivate and drive performance, with a focus on both short-term and long-term quantifiable objectives. Performance metrics used for these goals include the achievement of targets for net sales, adjusted operating income and free cash flow. In ~~2011,~~2012, the payments for short-term variable compensation were based on ~~77%~~91% achievement of the business goals.

Compensation for a significant majority of employees worldwide includes fixed base compensation and benefits, which vary according to local market customs, as well as a short-term variable cash bonus. The level of fixed compensation is paid in cash, usually on a monthly basis, and is designed to provide the employee with a reasonable standard of living relative to the compensation offered by peer companies. The amount of short-term variable cash bonus is designed to reward performance, with the payout amount based on the achievement of overall company results as well as individual performance against a written set of objectives. The payout cap for the short-term variable cash bonus, including for members of the Managing Board, is capped at 200% of the individual's personal target bonus.

Furthermore, to align our compensation programs with the interests of shareholders, senior executives receive a portion of their total compensation in the form of long-term compensation, which is granted as equity as a reward for performance. These grants are determined on an individual basis and approved by the Compensation Committee. These equity grants are predominantly made in the form of Restricted Stock Units (RSUs) with a staggered vesting period typically over three (40%), five (50%) and 10 years (10%) and stock options, which have a staggered vesting period typically over three years.

Managing Board compensation

The compensation granted to the members of the Managing Board in ~~2011~~2012 consisted of a fixed salary and other variable components, with the significant majority of compensation awarded in the form of QIAGEN equity.

Variable compensation included annual payments linked to business performance (bonuses), as well as long-term equity incentives that were awarded based on individual performance. Stock options granted to the Managing Board members must have an exercise price that is higher than the market price at the time of grant. Restricted Share Units granted to the Managing Board members, as is the case with all grants to employees, vest over a 10-year period. Some of these grants contain vesting

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hurdles related to the achievement of specific operational and financial goals that are not disclosed due to confidential reasons. The long-term vesting periods are designed to strengthen the Managing Board members' commitment to QIAGEN and achieving its strategic initiatives, which in turn would benefit shareholders and other stakeholders.

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The tables below state the amounts earned on an accrual basis by our Managing Board members in ~~2011.~~2012.


Year ended December 31, 2011	Annual Compensation
Year ended December 31, 2012							Annual Compensation
Name	Fixed Salary		Variable Cash Bonus	Other (1)	Total		Fixed Salary		Variable Cash Bonus	Other ⁽³⁾	Total
Managing Board:
Peer M. Schatz	$	1,305,000	539,000	1,000	$	1,845,000	$	1,226,000	168,000	5,000	$	1,399,000
Roland Sackers	$	576,000	194,000	26,000	$	796,000	$	540,000	60,000	34,000	$	634,000
Dr. Joachim Schorr(1)	$	366,000	138,000	38,000	$	542,000	$	113,000	—	635,000	$	748,000
Bernd Uder(2)	$	370,000	141,000	15,000	$	526,000	$	344,000	85,000	20,000	$	449,000

____________________


(1)	Dr. Joachim Schorr was a member of our Managing Board until April 30, 2012.


(2)	Bernd Uder was a member of our Managing Board until December 31, 2012.

(3)

Amounts include, among others, separation payments, inventor bonus and relocation costs. We also occasionally reimburse our Managing Directors' personal expenses related to attending out-of-town meetings but not directly related to their attendance. The value of such reimbursed personal expenses is reported above as “other.” Amounts do not include the reimbursement of certain expenses relating to travel incurred at the request of QIAGEN, other reimbursements or payments that in total did not exceed $10,000 or tax amounts paid by the Company to tax authorities in order to avoid double-taxation under multi-tax jurisdiction employment agreements.


Year ended December 31, 2011	Long-Term Compensation
Year ended December 31, 2012				Long-Term Compensation
Name	Defined Contribution Benefit Plan	Stock Options	Restricted Stock Units	Defined Contribution Benefit Plan		Stock Options	Restricted Stock Units	Performance Stock Units
Managing Board:
Peer M. Schatz	91,000	112,653	388,427	$	84,000	134,109	465,181	50,540
Roland Sackers	93,000	37,815	130,385	$	86,000	44,945	155,901	17,213
Dr. Joachim Schorr(1)	35,000	17,231	29,705	$	10,000	—	—	—
Bernd Uder(2)	57,000	16,652	28,708	$	52,000	19,549	45,207	66,384

____________________


(1)	Dr. Joachim Schorr was a member of our Managing Board until April 30, 2012


(2)	Bernd Under was a member of our Managing Board until December 31, 2012.

The Supervisory Board compensation for ~~2011~~2012 consists of fixed retainer compensation, additional retainer amounts for Chairman and Vice Chairman, and committee membership fees. Annual remuneration of the Supervisory Board members is as follows:



Fee paid to each member of the Supervisory Board	€30,000
Additional compensation payable to members holding the following positions:
Chairman of the Supervisory Board	€20,000
Vice Chairman of the Supervisory Board	€5,000
Chairman of the Audit Committee	€15,000
Chairman of the Compensation Committee	€10,000
Fee payable to each member of the Audit Committee	€7,500
Fee payable to each member of the Compensation Committee	€5,000

Members of the Supervisory Board also receive €1,000 for attending the Annual General Meeting and €1,000 for attending each meeting of the Supervisory Board.

Members of the Supervisory Board receive €1,000 for attending each meeting of any subcommittees (other than Audit

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Committee, Compensation Committee and Selection and Appointment Committee).

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Supervisory Board members also receive variable compensation, which is determined annually by the Compensation Committee pursuant to a formula based on growth of adjusted Earnings per Share provided that such remuneration will not exceed €5,000 per year. We did not pay any agency or advisory service fees to members of the Supervisory ~~Board other than $0.1 million to Dr. Colpan for his scientific consulting services, including travel reimbursements.~~Board.


Name	Fixed Remuneration		Chairman/ Vice- Chairman Committee	Committee Membership	Meeting Attendance	Subcommittee Meeting Attendance	Variable Cash Remuneration	Total		Fixed Remuneration		Chairman/ Vice- Chairman Committee	Committee Membership	Meeting Attendance	Subcommittee Meeting Attendance	Variable Cash Remuneration	Total
Supervisory Board:
Prof. Dr. Detlev H. Riesner	$	42,000	28,000	—	8,400	4,200	7,000	$	89,600	$	38,500	25,750	—	6,500	3,750	6,500	$	81,000
Dr. Werner Brandt	$	42,000	21,000	—	7,000	—	7,000	$	77,000	$	38,500	19,250	—	6,500	—	6,500	$	70,750
Dr. Metin Colpan	$	42,000	—	—	7,000	4,200	7,000	$	60,200	$	38,500	—	—	6,500	3,750	6,500	$	55,250
Erik Hornnaess	$	42,000	21,000	10,500	7,000	—	7,000	$	87,500	$	38,500	19,250	9,500	6,500	—	6,500	$	80,250
Prof. Dr. Manfred Karobath	$	42,000	—	7,000	7,000	4,200	7,000	$	67,200	$	38,500	—	6,500	6,500	2,500	6,500	$	60,500
Heino von Prondzynski	$	42,000	—	6,125	5,600	4,200	7,000	$	64,925	$	38,500	—	—	5,000	2,500	6,500	$	52,500
Elizabeth E. Tallett	$	21,000	—	5,250	4,200	—	3,500	$	33,950	$	38,500	—	16,000	5,000	—	6,500	$	66,000
Dr. V. Kallmeyer (1)	$	14,000	—	3,500	2,800	1,400	2,300	$	24,000

~~____________________~~

~~(1) Dr. V. Kallmeyer was a member of our~~ Supervisory ~~Board from June 2011 until October 2011.~~

~~Board~~board members also receive a variable component, in the form of share-based compensation. Stock options granted to the Supervisory Board members must have an exercise price that is higher than the market price at the time of grant. During ~~2011,~~2012, the following options or other share-based compensation were granted to the members of the Supervisory Board.


Year ended December 31, 2011	Grants
Year ended December 31, 2012			Grants
Name	Stock Options	Restricted Stock Units	Stock Options	Restricted Stock Units
Supervisory Board:
Prof. Dr. Detlev H. Riesner	1,355	4,671	1,563	10,000
Dr. Werner Brandt	1,355	4,671	1,563	10,000
Dr. Metin Colpan	1,355	4,671	1,563	10,000
Erik Hornnaess	1,355	4,671	1,563	10,000
Prof. Dr. Manfred Karobath	1,355	4,671	1,563	10,000
Heino von Prondzynski	1,355	4,671	1,563	10,000
Elizabeth E. Tallett			1,563	10,000

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The following table sets forth the vested and unvested options and stock awards of our officers and directors as of January 27, ~~2012:~~2013:

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Name	Total Vested Options	Total Unvested Options	Expiration Dates	Exercise Prices	Total Unvested Stock Awards	Total Vested Options	Total Unvested Options	Expiration Dates	Exercise Prices	Total Unvested Restricted and Performance Stock Units
Peer M. Schatz	2,107,371	234,096	9/30/2012 to 2/28/2021	$4.59 to $22.43	1,467,856	1,975,214	249,512	4/1/2013 to 2/28/2022	$6.02 to $22.43	1,666,950
Roland Sackers	60,198	77,563	2/28/2018 to 2/28/2021	$16.34 to $22.43	374,294	99,363	83,343	2/28/2018 to 2/28/2022	$15.59 to $22.43	547,408
Dr. Joachim Schorr	52,015	36,038	2/28/2017 to 2/28/2021	$16.34 to $22.43	193,683
Bernd Uder	47,599	28,703	2/28/2017 to 2/28/2021	$16.34 to $22.43	193,099	62,202	33,649	2/28/2017 to 2/28/2022	$15.59 to $22.43	257,336
Prof. Dr. Detlev H. Riesner	51,838	3,101	4/1/2013 to 2/28/2021	$6.02 to $22.43	19,785	46,818	3,017	4/1/2014 to 2/28/2022	$11.985 to $22.43	24,945
Dr. Werner Brandt	3,229	3,101	4/29/2018 to 2/28/2021	$16.34 to $22.43	16,553	4,876	3,017	4/29/2018 to 2/28/2022	$15.59 to $22.43	24,407
Dr. Metin Colpan	645,171	3,101	4/1/2012 to 2/28/2021	$6.02 to $22.43	19,785	346,818	3,017	4/1/2013 to 2/28/2022	$6.02 to $22.43	24,945
Erik Hornnaess	65,171	3,101	4/1/2013 to 2/28/2021	$6.02 to $22.43	19,785	46,818	3,017	4/1/2014 to 2/28/2022	$11.985 to $22.43	24,945
Prof. Dr. Manfred Karobath	59,171	3,101	4/1/2013 to 2/28/2021	$6.02 to $22.43	19,785	46,818	3,017	4/1/2014 to 2/28/2022	$11.985 to $22.43	24,945
Heino von Prondzynski	3,229	3,101	4/29/2018 to 2/28/2021	$16.34 to $22.43	16,553	4,876	3,017	4/29/2018 to 2/28/2022	$15.59 to $22.43	24,407
Elizabeth E. Tallett						—	1,563	2/28/2022	$15.59	10,000

Committees of the Supervisory Board

The Supervisory Board has established an Audit Committee, a Compensation Committee and a Selection and Appointment Committee, which are comprised of the following members:



Name of Supervisory Director	Independent	Member of Audit Committee	Member of Compensation Committee	Member of Selection and Appointment Committee
Prof. Dr. Detlev Riesner	Ÿ			Ÿ (Chairman)
Dr. Werner Brandt	Ÿ	Ÿ (Chairman)
Erik Hornnaess	Ÿ	Ÿ	Ÿ (Chairman)	Ÿ
Prof. Dr. Manfred Karobath	Ÿ		Ÿ
Heino von Prondzynski	Ÿ
Elizabeth A.E. Tallett	Ÿ	Ÿ	Ÿ

We believe that all of our Supervisory Directors, except for Dr. Metin Colpan, meet the independence requirements set forth in the Marketplace Rules of the NASDAQ Stock Market. Pursuant to the NASDAQ Rules, a majority of the Supervisory Directors must qualify as independent, as defined in the Rules. In ~~2011,~~2012, Dr. Colpan was not considered to be independent due to his consulting arrangement with the Company under which Dr. Colpan ~~continued to provide~~provided scientific advisory services to the ~~Company.~~Company in 2011, 2010 and 2009. In January 2012, the agreement under which Dr. Colpan provided scientific consulting services terminated. ~~Dr. Colpan does not serve on any committees~~

Table of ~~the Supervisory Board.~~Contents

Audit Committee

The Audit Committee operates pursuant to a charter approved by the Supervisory Board and available online at www.qiagen.com. The Audit Committee consists of three members, Dr. Brandt (Chairman), Mr. Hornnaess and Ms. Tallett, and meets at least quarterly. The Audit Committee members are appointed by the Supervisory Board and serve for a term of one

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year. We believe that all members of our Audit Committee meet the independence requirements as set forth in Rule 10A-3 of the Securities Exchange Act of 1934, as amended, and the Marketplace Rules of the NASDAQ. The Audit Committee reviews major financial risk exposures, pre-approves related-party transactions, and reviews any legal matter including compliance topics that could have a significant impact on the financial statements. Further, the Audit Committee is responsible to establish complaint procedures, including confidential, anonymous submission by employees of concerns, for the receipt, retention and treatment of complaints received regarding accounting, internal accounting controls, or auditing matters. The Audit Committee is also responsible together with the Managing Board for the proposal of the independent registered public accounting firm to the Supervisory Board, which proposes the appointment of the independent registered public accounting firm to the General Meeting of shareholders. The independent registered public accounting firm audits the consolidated financial statements and certain local books and records of QIAGEN and its subsidiaries, and the Audit Committee is further responsible for pre-approving the fees for such services. Additionally, the Audit Committee reviews the performance of the independent registered public accounting firm with management, discussing on a quarterly basis the scope and results of the reviews and audits with the independent registered public accounting firm; discusses our financial accounting and reporting principles and policies and the adequacy of our internal accounting, financial and operating controls and procedures with the independent registered public accounting firm and management; considers and approves any recommendations regarding changes to our accounting policies and processes; reviews with management and the independent registered public accounting firm our quarterly earnings reports prior to their release to the press; and reviews the quarterly and annual reports (reported on Forms 6-K and 20-F) to be furnished to or filed with the Securities and Exchange Commission and the Deutsche Boerse. The Board has designated Dr. Brandt as an “audit committee financial expert” as that term is defined in the United States Securities and Exchange Commission rules adopted pursuant to the Sarbanes-Oxley Act of 2002.

Compensation Committee

The Compensation Committee operates pursuant to a charter approved by the Supervisory Board and available online at www.qiagen.com. The Compensation Committee consists of three members, Mr. Erik Hornnaess (Chairman), Ms. Elizabeth Tallett and Professor Karobath. Members are appointed by the Supervisory Board and serve for a term of one year. We believe that all of the members of the Compensation Committee meet the independence requirements set forth in the Marketplace Rules of the NASDAQ. The Compensation Committee reviews and approves all equity-based compensation, reviews and approves the annual salaries, bonuses and other benefits of executive officers, and reviews general policies relating to employee compensation and benefits.

Selection and Appointment Committee

The Selection and Appointment Committee operates pursuant to a charter approved by the Supervisory Board and available online at www.qiagen.com. The current members of the Selection and Appointment Committee are Prof. Dr. Riesner (Chairman) and Mr. Hornnaess. Members are appointed by the Supervisory Board and serve for a term of one year. The Selection and Appointment Committee prepares the selection criteria and appointment procedures for members of our Supervisory Board and Managing Board; periodically evaluates the scope and composition of the Managing Board and Supervisory Board and proposes the profile of the Supervisory Board in relation thereto. Additionally, the Committee periodically evaluates the functioning of individual members of the Managing Board and Supervisory Board and reports the results thereof to the Supervisory Board and proposes the (re-)appointments of members of our Managing Board and Supervisory Board. The Committee prepares and submits to the Supervisory Board on an annual basis a report of its deliberations and findings.

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Share Ownership

The following table sets forth certain information as of January 27, ~~2012~~2013 concerning the ownership of Common Shares by our directors and officers. In preparing the following table, we have relied on information furnished by such persons.

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Name and Country of Residence	Shares Beneficially Owned (1) Number		Percent Ownership (2)		Shares Beneficially Owned⁽¹⁾ Number		Percent Ownership ⁽²⁾
Peer M. Schatz, Germany	1,606,189	(3)	0.69	%	1,771,128	(3)	0.75	%
Roland Sackers, Germany	24,852	(4)	*		—	(4)	*
Dr. Joachim Schorr, Germany	—	(5)	*
Bernd Uder, Germany	—	(6)	*		—	(5)	*
Prof. Dr. Detlev H. Riesner, Germany	1,752,735	(7)	0.75	%	1,654,993	(6)	0.70	%
Dr. Werner Brandt, Germany	6,882	(8)	*		8,377	(7)	*
Dr. Metin Colpan, Germany	4,538,703	(9)	1.94	%	4,540,961	(8)	1.92	%
Erik Hornnaess, Spain	11,922	(10)	*		14,180	(9)	*
Professor Dr. Manfred Karobath, Austria	2,257	(11)	*		9,015	(10)	*
Heino von Prondzynski, Switzerland	882	(12)	*		2,377	(11)	*
Elizabeth Tallett, United States	—		*		—	(12)	*

____________________

* Indicates that the person beneficially owns less than 0.5% of the Common Shares issued and outstanding as of January 27, ~~2012.~~2013.


(1)	The number of Common Shares issued and outstanding as of January 27, ~~2012~~2013 was ~~234,260,408.~~236,563,920. The persons and entities named in the table have sole voting and investment power with respect to all shares shown as beneficially owned by them and have the same voting rights as shareholders with respect to Common Shares.


(2)	Does not include Common Shares subject to options or awards held by such persons at January 27, ~~2012.~~2013. See footnotes below for information regarding options now exercisable or that could become exercisable within 60 days of the date of this table.

(3)

Does not include ~~2,226,064~~2,097,769 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$4.590~~$6.020 to $22.430 per share. Options expire in increments during the period between ~~9/2012~~4/2013 and 2/~~2021.~~2022. Does not include ~~316,627~~265,127 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(4)

Does not include ~~99,363~~140,137 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$16.340~~$15.590 to $22.430 per share. Options expire in increments during the period between 2/2018 and 2/~~2021.~~2022. Does not include 84,664 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(5)

Does not include ~~70,342~~77,267 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$16.34~~$15.590 to $22.430 per share. Options expire in increments during the period between 2/2017 and 2/~~2021.~~2022. Does not include ~~48,221~~40,801 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(6)

Does not include ~~62,202~~48,341 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$16.340~~$11.985 to $22.430 per share. Options expire in increments during the period between ~~2/2017~~4/2014 and 2/~~2021.~~2022. Includes 1,652,068 shares held by Riesner Verwaltungs GmbH, of which Professor Riesner is the sole stockholder. Does not include ~~47,354~~1,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(7)

Does not include ~~53,485~~6,399 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from $15.590 to $22.430 per share. Options expire in increments during the period between 4/2018 and 2/2022. Does not include 1,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(8)

Does not include 348,341 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from $6.018 to $22.430 per share. Options expire in increments during the period between 4/2013 and 2/~~2021.~~2022. Includes ~~1,752,068~~3,738,703 shares held by ~~Riesner~~CC Verwaltungs GmbH, of ~~which Professor Riesner is the sole stockholder.~~

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which Dr. Colpan is the sole stockholder and 800,000 shares held by Colpan GbR. Does not include 1,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(9)

Does not include ~~2,146~~48,341 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from $11.985 to $22.430 per share. Options expire in increments during the period between 4/2014 and 2/2022. Does not include 1,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

~~(8)~~(10)

Does not include ~~4,876~~48,341 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$16.340~~$11.985 to $22.430 per share. Options expire in increments during the period between 4/~~2018~~2014 and 2/~~2021.~~2022. Does not include ~~2,146 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.~~


~~(9)~~	Does not include 646,818 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from $6.018 to $22.430 per share. Options expire

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in increments during the period between 4/2012 and 2/2021. Includes 3,738,703 shares held by CC Verwaltungs GmbH, of which Dr. Colpan is the sole stockholder and 800,000 shares held by Colpan GbR. Does not include 2,146 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

~~(10)~~

Does not include 66,818 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from $6.018 to $22.430 per share. Options expire in increments during the period between 4/2013 and 2/2021. Does not include 2,1461,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(11)

Does not include ~~60,818~~6,399 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ranging from ~~$6.018~~$15.590 to $22.430 per share. Options expire in increments during the period between 4/~~2013~~2018 and 2/~~2021.~~2022. Does not include ~~2,146~~1,770 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.

(12)

Does not include ~~4,876~~521 shares issuable upon the exercise of options now exercisable or that could become exercisable within 60 days from the date of this table having exercise prices ~~ranging from $16.340 to $22.430~~of $15.59 per share. Options expire ~~in increments during the period between 4/2018 and~~on 2/~~2021. Does not include 2,146 shares issuable upon the release of unvested stock awards that could become releasable within 60 days from the date of this table.~~2022.

Employees

As of December 31, ~~2011,~~2012, we employed ~~3,938~~3,999 individuals, of which ~~19%~~17% worked in research and development, ~~39%~~40% in sales, ~~23%~~25% in production/logistics, 7% in marketing and ~~12%~~11% in administration.


Region	Research & Development	Sales	Production	Marketing	Administration	Total	Research & Development	Sales	Production	Marketing	Administration	Total
Americas	153	511	238	55	115	1,072	139	553	219	60	123	1,094
Europe	556	555	583	179	270	2,143	478	585	695	168	240	2,166
Asia Pacific & Rest of World	49	443	103	47	81	723	53	462	86	61	77	739
December 31, 2011	758	1,509	924	281	466	3,938
December 31, 2012							670	1,600	1,000	289	440	3,999

At December 31, ~~2010~~2011 and ~~2009,~~2010, we employed ~~3,587~~3,938 and ~~3,495~~3,587 individuals, respectively. None of our employees is represented by a labor union or subject to a collective bargaining agreement. Management believes that its relations with employees are good.

Stock Plans

We adopted the QIAGEN N.V. Amended and Restated 2005 Stock Plan (the Plan) which was approved by our shareholders on June 14, 2005. Pursuant to the Plan, stock rights, which include options to purchase our Common Shares, stock grants and stock-based awards, may be granted to employees and consultants of QIAGEN and its subsidiaries and to Supervisory Directors. An aggregate of 31.0 million Common Shares have been reserved for issuance pursuant to the Plan, subject to certain antidilution adjustments. Options granted pursuant to the Plan may either be incentive stock options within the meaning of Section 422 of the United States Internal Revenue Code of 1986, as amended (the Code), or non-qualified stock options. Options granted to members of the Supervisory Board and the Managing Board must have an exercise price that is higher than the market price at the time of grant. Generally, each of the options has a term of ten years, subject to earlier termination in the event of death, disability or other termination of employment. The vesting and exercisability of certain stock rights will be accelerated in the event of a Change of Control, as defined in the agreements under the Plan.

The Plan is administered by the Compensation Committee of the Supervisory Board, which selects participants from among eligible employees, consultants and directors and determines the number of shares subject to the stock-based award, the length of time the award will remain outstanding, the manner and time of the award's vesting, the price per share subject to the award and other terms and conditions of the award consistent with the Plan. The Compensation Committee's decisions are subject to the approval of the Supervisory Board.

In connection with the acquisition of Digene Corporation during the third quarter of 2007, the Company assumed three

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additional equity incentive plans and exchanged Digene stock options and awards into the Company's Common Shares. No

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new grants will be made under these plans.

The Compensation Committee has the power, subject to Supervisory Board approval, to interpret the plans and to adopt such rules and regulations (including the adoption of “sub plans” applicable to participants in specified jurisdictions) as it may deem necessary or appropriate. The Compensation Committee or the Supervisory Board may at any time amend the plans in any respect, subject to Supervisory Board approval, and except that (i) no amendment that would adversely affect the rights of any participant under any option previously granted may be made without such participant's consent and (ii) no amendment shall be effective prior to shareholder approval to the extent such approval is required to ensure favorable tax treatment for incentive stock options or to ensure compliance with Rule 16b-3 under the United States Securities Exchange Act of 1934, as amended (the Exchange Act) at such times as any participants are subject to Section 16 of the Exchange Act.

As of January 27, ~~2012,~~2013, there were ~~6.1~~5.3 million options outstanding with exercise prices ranging between ~~$1.85~~$4.35 and $23.54 and expiring between ~~January 31, 2012~~February 13, 2013 and ~~December~~November 30, ~~2021.~~2022. The exercise price of the options is the fair market value of the Common Shares as of the date of grant or a premium above fair market value. Additionally, there were ~~5.6~~6.9 million ~~restricted~~ stock unit awards outstanding as of January 27, ~~2012.~~2013. These awards will be released between February ~~29, 2012~~28, 2013 and ~~November 30, 2021.~~October 31, 2022. As of January 27, ~~2012,~~2013, options to purchase ~~3.5~~3.1 million Common Shares and ~~2.3~~2.8 million ~~restricted~~ stock ~~units~~unit awards were held by the officers and directors of QIAGEN, as a group.


Item 7.	Major Shareholders and Related Party Transactions

The following table sets forth certain information as of December 31, ~~2011,~~2012, concerning the ownership of Common Shares of each holder of greater than five percent ownership. None of these holders have any different voting rights than other holders of our Common Shares.


Name and Country of Residence	Shares Beneficially Owned Number		Percent Ownership (1)		Shares Beneficially Owned Number		Percent Ownership⁽¹⁾
BlackRock, Inc., United States	13,094,141	(2)	5.59	%	14,198,775	(2)	6.00	%

____________________


(1)	The percentage ownership was calculated based on ~~234,220,808~~236,486,584 Common Shares issued and outstanding as of December 31, ~~2011.~~2012.


(2)	Of the ~~13,094,141~~14,198,775 shares attributed to BlackRock, Inc., it has sole voting power and sole dispositive power over all ~~13,094,141~~14,198,775 shares. This information is based solely on the Schedule 13G filed by BlackRock, Inc. with the Securities and Exchange Commission on February ~~9, 2012,~~5, 2013, which reported ownership as of December 31, ~~2011.~~2012.

Our common stock is traded on the NASDAQ Global Select Market in the United States and on the Prime Standard Segment of the Frankfurt Stock Exchange in Germany. A significant portion of our shares are held electronically in ~~street name,~~the account of a stockbroker, therefore we generally have no way of determining who our shareholders are, their geographical location or how many shares a particular shareholder owns. As of January 27, ~~2012,~~2013, there were ~~197~~198 shareholders of record of our Common Shares.

Control of Registrant

To our knowledge, we are not directly or indirectly owned or controlled by another corporation, by any foreign government, or by any other natural or legal person. As of January 27, ~~2012,~~2013, the officers and directors of QIAGEN as a group beneficially owned ~~7,944,422~~8.0 million Common Shares, or ~~3.39%~~3.38% of the then outstanding Common Shares.

Related Party Transactions

In 2011 and 2010, we had a consulting agreement with Dr. Metin Colpan, our former Chief Executive Officer and current Supervisory Board member, pursuant to which Dr. Colpan is paid a fee of EUR 2,750 per day for scientific consulting services, subject to adjustment. During each of the years ended December 31, 2011 and 2010, we expensed approximately $0.1 million approximately $0.3 million, respectively, to Dr. Colpan for scientific consulting services under this agreement. In January 2012, the agreement under which Dr. Colpan provided scientific consulting services terminated.

We have a 100% interest in QIAGEN Finance (Luxembourg) S.A. (QIAGEN Finance) and QIAGEN Euro Finance (Luxembourg) S.A. (Euro Finance), which were established for the purpose of issuing convertible debt. As discussed in Note 1210 of the Notes to the Consolidated Financial Statements, QIAGEN Finance and Euro Finance are variable interest entities ~~with no~~for which we do not hold any variable interests and are not the primary beneficiary, thus they are not consolidated. Accordingly, the convertible debt is not included in the consolidated statements of QIAGEN N.V., though we do report the full obligation of the debt through our liabilities to QIAGEN Finance and Euro Finance. As of December 31, ~~2011~~2012 and ~~2010,~~2011, we had a loan payable to QIAGEN Finance of $145.0 million and accrued

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interest due to QIAGEN Finance of ~~$4.4~~$4.4 million ~~and $3.3 million, respectively,~~ and amounts receivable from QIAGEN Finance of ~~$3.4~~$3.4 million ~~and $2.3 million, respectively.~~. As of December 31, ~~2011~~2012 and ~~2010,~~2011, we had a loan payable to Euro Finance of $300.0 million, accrued interest due to Euro Finance of ~~$3.0~~$2.6 million and $3.0 million, respectively and amounts receivable from Euro Finance of ~~$1.6 million.~~$1.3 million and $1.6 million, respectively.

In 2011, we had a consulting agreement with Dr. Metin Colpan, our former Chief Executive Officer and current

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Supervisory Board member, pursuant to which Dr. Colpan is paid a fee of EUR 2,750 per day for consulting services, subject to adjustment. We incurred consulting expenses of approximately $0.1 million as of December 31, 2011 for scientific consulting services under this agreement. In January 2012, the agreement under which Dr. Colpan provided scientific consulting services terminated.

During 2012 we entered into a development and license agreement with a company in which we also hold an interest. Under the terms of this agreement we will pay a total of $7.7 million in 2013 and another $2.0 million in total based on the achievement of certain milestones.

From time to time, we have transactions with other companies in which we hold an interest all of which are individually and in the aggregate immaterial, as summarized in the table below.


Year ending December 31, (in thousands)	2011		2010		2012		2011
Net sales	$	6,287	$	2,605	$	7,068	$	6,287
Loans receivable	$	1,539	$	1,560
Accounts receivable	$	3,606	$	2,400	$	2,651	$	3,606
Accounts payable	$	4,642	$	1,755	$	3,699	$	4,642
Loans receivable					$	1,674	$	1,539


Item 8.	Financial Information

See Item 18.

Legal Proceedings

For information on legal proceedings, see Note 1820 of the Notes to Consolidated Financial Statements.

While no assurances can be given regarding the outcome of proceedings described in Note ~~18,~~20, based on information currently available, we believe that the resolution of these matters is unlikely to have a material adverse effect on our financial position or results of future operations for QIAGEN N.V. as a whole. However, because of the nature and inherent uncertainties of litigation, should the outcomes be unfavorable, certain aspects of our business, financial condition, and results of operations and cash flows could be materially adversely affected.

Statement of Policy on Dividend Distribution

We have not paid any dividends on our Common Shares since our inception and do not intend to pay any dividends on our Common Shares in the foreseeable future. We intend to retain our earnings, if any, for the development of our business.


Item 9.	The Offer and Listing

Effective July 3, 2006, our Common Shares began trading on the NASDAQ Global Select Market under the symbol QGEN. Previously, since February 15, 2005, our Common Shares had been quoted on the NASDAQ National Market under the symbol QGEN. Prior to that, since June 27, 1996, our Common Shares had been quoted on the NASDAQ National Market under the symbol QGENF. The following tables set forth the annual high and low sale prices for the last five years, the quarterly high and low sale prices for the last two years, and the monthly high and low sale prices for the last six months of our Common Shares on the NASDAQ Global Select and NASDAQ National Market, as applicable.



	High ($)	Low ($)
Annual
2008	23.53	12.52
2009	23.58	14.32
2010	24.00	16.86
2011	22.20	12.47
2012	19.20	14.16

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High ($) Low ($)
Annual
2007 23.83
15.22
2008 23.53
12.52
2009 23.58
14.32
2010 24.00
16.86
2011 22.20
12.47
High ($) Low ($)
Quarterly 2010:
First Quarter 23.71
20.26
Second Quarter 24.00
19.17
Third Quarter 20.80
17.56
Fourth Quarter 20.02
16.86


	High ($)	Low ($)	High ($)	Low ($)
Quarterly 2011:
First Quarter	21.00	18.02	21.00	18.02
Second Quarter	22.20	18.45	22.20	18.45
Third Quarter	19.75	13.05	19.75	13.05
Fourth Quarter	15.09	12.47	15.09	12.47
Quarterly 2012:
First Quarter (through March 23, 2012)	15.43	14.42
First Quarter			16.97	14.05
Second Quarter			17.31	14.78
Third Quarter			19.11	15.90
Fourth Quarter			19.20	17.16
Quarterly 2013:
First Quarter (through February 28, 2013)			22.20	18.44

	High ($)	Low ($)	High ($)	Low ($)
Monthly
September 2011	15.49	13.05
October 2011	14.67	12.47
November 2011	14.93	12.96
December 2011	15.09	13.20
January 2012	16.97	14.05
February 2012	16.23	15.08
September 2012			19.11	17.62
October 2012			19.41	17.14
November 2012			18.90	16.98
December 2012			18.89	17.57
January 2013			21.31	18.44
February 2013			22.20	20.30

From September 25, 1997, to December 31, 2002, our Common Shares were traded on the Frankfurt Stock Exchange, Neuer Markt under the symbol QIA and with the security code number 901626. As of January 1, 2003, the trading of our Common Shares was transferred to the Prime Standard Segment of the Frankfurt Stock Exchange, where QIAGEN is a member of the TecDAX, an index of the 30 leading technology companies in Germany not included in the benchmark DAX index. The following table sets forth the annual high and low sale prices for the last five years, the quarterly high and low sale prices for the last two years, and the monthly high and low sale prices for the last six months of our Common Shares on the Prime Standard.



	High (EUR)	Low (EUR)
Annual
2008	15.77	10.04
2009	15.98	11.12
2010	17.87	12.06
2011	15.25	9.07
2012	15.05	10.69

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	High (EUR)	Low (EUR)
Annual
2007	16.44	11.45
2008	15.77	10.04
2009	15.98	11.12
2010	17.87	12.06
2011	15.25	9.07
	High (EUR)	Low (EUR)
Quarterly 2010:
First Quarter	17.62	14.67
Second Quarter	17.87	15.94
Third Quarter	16.25	13.12
Fourth Quarter	14.95	12.06
	High (EUR)	Low (EUR)	High (EUR)	Low (EUR)
Quarterly 2011:
First Quarter	15.25	12.85	15.25	12.85
Second Quarter	14.97	12.95	14.97	12.95
Third Quarter	13.74	9.65	13.74	9.65
Fourth Quarter	11.20	9.07	11.20	9.07
Quarterly 2012:
First Quarter (through March 23, 2012)	11.65	11.12
First Quarter			12.81	10.69
Second Quarter			13.49	11.31
Third Quarter			14.73	13.04
Fourth Quarter			15.05	13.11
Quarterly 2013:
First Quarter (through February 28, 2013)			16.55	13.75

High (EUR) Low (EUR)
Monthly:
September 2011 10.86
9.65
October 2011 10.47
9.07
November 2011 10.99
9.46
December 2011 11.20
10.14
January 2012 12.81
10.69
February 2012 12.53
11.45



	High (EUR)	Low (EUR)
Monthly:
September 2012	14.73	14.02
October 2012	15.05	13.11
November 2012	14.54	13.31
December 2012	14.50	13.41
January 2013	15.69	13.75
February 2013	16.55	15.15


Item 10.	Additional Information

Memorandum and Articles of Association

We are a public company with limited liability (naamloze vennootschap) incorporated under Dutch law and registered with the Dutch Trade Register under file number 12036979. Set forth below is a summary of certain provisions of our full Articles of Association, as lastly amended on June 30, 2011, or the Articles, and Dutch law, where appropriate. The Dutch Corporate Governance Code, or the Code, that was published on December 9, 2003 (and revised on December 10, 2008) contains principles of good corporate governance and best practice provisions. The Code contains the principles and concrete provisions which the persons involved in a listed company (including Managing Board members and Supervisory Board members) and stakeholders should observe in relation to one another. A listed company should either comply with, or if not, explain in its annual report why and to what extent it does not comply, with the best practice provisions of the Code. The Code has been taken into account in the summary below.

This summary does not purport to be complete and is qualified in its entirety by reference to the Articles, Dutch Law and the Code.

Corporate Purpose

Our objects include, without limitation, the performance of activities in the biotechnology industry, as well as

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incorporating, acquiring, participating in, financing, managing and having any other interest in companies or enterprises of any nature, raising and lending funds and such other acts as may be conducive to our business.

Managing Directors

QIAGEN shall be managed by a Managing Board consisting of one or more Managing Directors under the supervision of the Supervisory Board. The majority view under Dutch law is that in managing QIAGEN, the Managing Directors must take into account our interests and our business and the interests of all stakeholders (which includes but is not limited to our shareholders). Managing Directors shall be appointed by the General Meeting of our shareholders upon the joint meeting of the Supervisory Board and the Managing Board, or Joint Meeting, having made a binding nomination for each vacancy. However,

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the General Meeting may at all times overrule the binding nature of such a nomination by a resolution adopted by at least a two-thirds majority of the votes cast, if such majority represents more than half the issued share capital. This is different from the provisions of many American corporate statutes, including the Delaware General Corporation Law, which give the directors of a corporation greater authority in choosing the executive officers of a corporation. Under our Articles, the General Meeting may suspend or dismiss a managing director at any time. The Supervisory Board shall also at all times be entitled to suspend (but not to dismiss) a Managing Director. The Articles provide that the Supervisory Board may adopt management rules governing the internal organization of the Managing Board.

Furthermore, the Supervisory Board shall determine the salary, the bonus, if any, and the other compensation terms and conditions of employment of the Managing Directors within the scope of the remuneration policy. The remuneration policy of the Managing Board has been adopted in our Annual General Meeting on June 14, 2005.

Under Dutch law, in the event that there is a conflict of interest between a Managing Director and us ~~we are represented~~on a certain matter, that Managing Director shall not participate in the discussions and voting on that matter. If all our managing directors have a conflict of interest, such resolution shall be adopted by the Supervisory Board. ~~However,~~If all Supervisory Directors have an conflict of interest as well, the General Meeting ~~should at all times in an event of a conflict of interest~~will be ~~given the opportunity to appoint a person who is~~ authorized to ~~represent QIAGEN in~~resolve on such ~~event.~~matter. According to the Code, any conflict of interest or apparent conflict of interest between the company and Managing Directors should be avoided. Decisions to enter into transactions under which Managing Directors would have conflicts of interest that are of material significance to the Company and/or to the relevant Managing Director require the approval of the Supervisory Board.

Supervisory Directors

The Supervisory Board shall be responsible for supervising the policy pursued by the Managing Board and our general course of affairs. Under our Articles, the Supervisory Directors are required to serve our interests and our business and the interest of all stakeholders (which includes but is not limited to our shareholders) in fulfilling their duties. The Supervisory Board shall consist of such number of members as the Joint Meeting may from time to time determine, with a minimum of three members. The Supervisory Directors shall be appointed by the General Meeting upon the Joint Meeting having made a binding nomination for each vacancy. If during a financial year a vacancy occurs in the Supervisory Board, the Supervisory Board may appoint a Supervisory Director who will cease to hold office at the next Annual General Meeting. Under Dutch law and the Code, a Supervisory Director must excuse him or herself in the case of any conflict of interest. If all Supervisory Directors have a conflict of interest, the relevant resolution shall be adopted by the General Meeting. Decisions to enter into transactions under which a Supervisory Director would have a conflict of interest that are of material significance to QIAGEN and/or to the Supervisory Director concerned, require the approval of the Supervisory Board.

Under Dutch law and the Code, the General Meeting determines the compensation of the Supervisory Directors upon the proposal of the Compensation Committee. Any shares held by a Supervisory Director in the company on whose board he sits should be long-term investments.

Under our Articles, the General Meeting may suspend or dismiss a Supervisory Director at any time. This is different from the provisions of many American corporate statutes, including the Delaware General Corporation Law, which provides that directors may vote to fill vacancies on the board of directors of a corporation.

Liability of Managing Directors and Supervisory Directors

Under Dutch law, as a general rule, Managing Directors and Supervisory Directors are not liable for obligations we incur. Under certain circumstances, however, they may become liable, either towards QIAGEN (internal liability) or to others (external liability), although some exceptions are described below.

Liability towards QIAGEN

Failure of a Managing or Supervisory Director to perform his or her duties does not automatically lead to liability. Liability is only incurred in the case of a clear, indisputable shortcoming about which no reasonably judging business-person would have any doubt. In addition, the Managing or Supervisory Director must be deemed to have been grossly negligent.

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Managing Directors are jointly and severally liable for failure of the Managing Board as a whole, but an individual Managing Director will not be held liable if he or she is determined not to have been responsible for the mismanagement and has not been negligent in preventing its consequences. Supervisory Directors are jointly and severally liable for failure of the Supervisory Board as a whole, but an individual Supervisory Director will not be held liable if he or she is determined not to have been responsible for the mismanagement and has not been negligent in preventing its consequences.

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Liability for Misrepresentation in Annual Accounts

Managing and Supervisory Directors are also jointly and severally liable to any third party for damages suffered as a result of misrepresentation in the annual accounts, annual report or interim statements of QIAGEN, although a Managing or Supervisory Director will not be held liable if found not to be personally responsible for the misrepresentation. Moreover, a Managing or Supervisory Director may be found to be criminally liable if he or she deliberately publishes false annual accounts or deliberately allows the publication of such false annual accounts.

Tort Liability

Under Dutch law, there can be liability if one has committed a tort (onrechtmatige daad) against another person. Although there is no clear definition of “tort” under Dutch law, breach of a duty of care towards a third party is generally considered to be a tort. Therefore, a Dutch corporation may be held liable by any third party under the general rule of Dutch laws regarding tort claims. In exceptional cases, Managing Directors and Supervisory Directors have been found liable on the basis of tort under Dutch common law, but it is generally difficult to hold a Managing or Supervisory Director personally liable for a tort claim. Shareholders cannot base a tort claim on any losses which derive from and coincide with losses we suffered. In such cases, only we can sue the Managing or Supervisory Directors.

Criminal Liability

Under Dutch law, if a legal entity has committed a criminal offence, criminal proceedings may be instituted against the legal entity itself as well as against those who gave order to or were in charge of the forbidden act. As a general rule, it is held that a Managing Director is only criminally liable if he or she played a reasonably active role in the criminal act.

Indemnification

Article 27 of our Articles ~~provide~~provides that we shall indemnify every person who is or was a Managing Director or Supervisory Director against all expenses (including attorneys’ fees) judgments, fines and amounts paid in settlement with respect to any threatened pending or completed action, suit or proceeding as well as against expenses (including attorneys’ fees) actually and reasonably incurred in connection with the defense or settlement of an action or proceeding, if such person acted in good faith and in a manner he reasonably could believe to be in or not opposed to our best interests. An exception is made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable for gross negligence or willful misconduct in the performance of his or her duty to us.

Classes of Shares

The authorized classes of our shares consist of Common Shares, Financing Preference Shares and Preference Shares. No Financing Preference Shares or Preference Shares have been issued.

Common Shares

Common Shares are issued in registered form only. Common Shares are available either without issue of a share certificate, or Type I shares, or with issue of a share certificate, or Type II shares, in either case in the form of an entry in the share register. At the discretion of the Supervisory Board, Type I shares may be issued and the holders of such Type I shares will be registered in either our shareholders register with American Stock Transfer & Trust Company, or New York Transfer Agent, our transfer agent and registrar in New York, or our shareholder register with TMF FundServices B.V., Westblaak 89, NL-3012 KG Rotterdam, the Netherlands. The Type II shares are registered with our New York Transfer Agent.

The transfer of registered shares requires that we issue a written instrument of transfer and the written acknowledgement of such transfer (or, in the case of Type II shares, the New York Transfer Agent (in our name)), and surrender of the share certificates, if any, to us or (in our name) to the New York Transfer Agent. Upon surrender of a share certificate for the purpose of transfer of the relevant shares, we (or the New York Transfer Agent in our name) acknowledge the transfer by endorsement on the share certificate or by issuance of a new share certificate to the transferee, at the discretion of the Managing Board.

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Financing Preference Shares

No Financing Preference Shares are currently issued or outstanding. If issued, Financing Preference Shares will be issued in registered form only. No share certificates are issued for Financing Preference Shares. Financing Preference Shares must be fully paid up upon issue. The preferred dividend rights attached to Financing Preference Shares are described under “Dividends” below. We have no present plans to issue any Financing Preference Shares.

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Preference Shares

No Preference Shares are currently issued or outstanding. If issued, Preference Shares will be issued in registered form only. No share certificates are issued for Preference Shares. Only 25% of the nominal value thereof is required to be paid upon subscription for Preference Shares. The obligatory payable part of the nominal amount (or the call) must be equal for each Preference Share. The Managing Board may, subject to the approval of the Supervisory Board, resolve on which day and up to which amount a further call must be paid on Preference Shares which have not yet been paid up in full. The preferred dividend rights attached to Preference Shares are described under “Dividends” below.

Pursuant to our Articles and the resolution adopted by our General Meeting on June 16, 2004, QIAGEN’s Supervisory Board is entitled to resolve to issue Preference Shares in case of an intended take-over of our Company by (i) any person who alone or with one or more other persons, directly or indirectly, have acquired or given notice of an intent to acquire (beneficial) ownership of an equity stake which in aggregate equals 20% or more of our share capital then outstanding or (ii) an “adverse person” as determined by the Supervisory Board. For this purpose, an “adverse person” is generally any (legal) person, alone or together with affiliates or associates, with an equity stake in our Company which the Supervisory Board considers to be substantial and where the Supervisory Board is of the opinion that this (legal) person has engaged in an acquisition that is intended to cause or pressure QIAGEN to enter into transactions intended to provide such person with short-term financial gain under circumstances that would not be in the interest of QIAGEN and our shareholders or whose ownership is reasonably likely to cause a material adverse impact on our business prospects.

On August 2, 2004, we entered into an agreement, or Option Agreement, with Stichting Preferente Aandelen QIAGEN, or ~~SPAQ.~~SPAQ which was most recently amended on June 4, 2012. Pursuant to the Option Agreement, SPAQ was granted an option to acquire such number of Preference Shares as are equal to the total number of all outstanding Common Shares minus one in our share capital at the time of the relevant exercise of the right. ~~The~~SPAQ may exercise its right to acquire the Preference Shares in all situations that it believes that our interest or our stakeholders is ~~granted subject~~at risk (which situations include but are not limited to (i) receipt of a notification from the Managing Board that a takeover is imminent and (ii) receipt of a notification from the Managing Board that one or more activist shareholders take a position that is not in the interest of QIAGEN, our shareholders or our other stakeholders), provided that the conditions ~~referred to~~mentioned in the previous ~~paragraph.~~paragraph have been met. Due to the implementation of the EC Directive on Takeover Bids in Dutch legislation, the exercise of the option to acquire Preference Shares by SPAQ and the subsequent issuance of Preference Shares to SPAQ needs to be done with due observance and in consideration of the restrictions imposed by the Public Offer Rules.

SPAQ was incorporated on August 2, 2004. Its principal office is located at Spoorstraat 50, 5911 KJ Venlo, The Netherlands. Its statutory objectives are to protect our interests and our enterprise and the enterprises of companies which are linked to us. SPAQ shall attempt to accomplish its objectives by way of acquiring Preference Shares in the share capital of QIAGEN and to exercise the voting rights in our interests and the interests of our stakeholders.

The board of SPAQ shall consist of at least two directors. Upon incorporation of SPAQ, two members were appointed to the board of SPAQ. Additional board members shall be appointed by the board of SPAQ. Board resolutions will be adopted by unanimity of the votes cast. SPAQ will be represented either by its board or by the chairman of its board.

Pre-emptive Rights

Under our Articles, existing holders of Common Shares will have pre-emptive rights in respect of future issuances of Common Shares in proportion to the number of Common Shares held by them, unless limited or excluded as described below. Holders of Common Shares shall not have pre-emptive rights in respect of future issuances of Financing Preference Shares or Preference Shares. Holders of Financing Preference Shares and Preference Shares shall not have pre-emptive rights in respect of any future issuances of share capital. Pre-emptive rights do not apply with respect to shares issued against contributions other than in cash or shares issued to our employees or one of our group companies. Under our Articles, the Supervisory Board has the power to limit or exclude any pre-emptive rights to which shareholders may be entitled, provided that it has been authorized by the General Meeting to do so. The authority of the Supervisory Board to limit or exclude pre-emptive rights can only be exercised if at that time the authority to issue shares is in full force and effect. The authority to limit or exclude pre-emptive rights may be extended in the same manner as the authority to issue shares. If there is no designation of the Supervisory Board to limit or exclude pre-emptive rights in force, the General Meeting shall have authority to limit or exclude such pre-emptive rights, but only upon the proposal of the Supervisory Board.

Resolutions of the General Meeting (i) to limit or exclude pre-emptive rights or (ii) to designate the Supervisory Board as the corporate body that has authority to limit or exclude pre-emptive rights, require a majority of at least two-thirds of the votes

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cast in a meeting of shareholders if less than 50% of the issued share capital is present or represented. For these purposes, issuances of shares include the granting of rights to subscribe for shares, such as options and warrants, but not the issue of shares upon exercise of such rights.

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On ~~July 20, 2007,~~June 27, 2012, the General Meeting resolved to authorize the Supervisory Board until December 27, 2013 to issue Common Shares and Financing Preference Shares or grant rights to subscribe for such shares, the aggregate par value of which shall be equal to ~~those~~the aggregate par value of all shares ~~for a period~~issued and outstanding in the capital of ~~5 years commencing on October 11, 2007 and for a maximum of Common Shares and Financing Preference Shares~~the Company as at December 31, 2011 as included in ~~our authorized share capital (as included in our Articles).~~the Annual Accounts for Fiscal Year 2011.

The General Meeting subsequently resolved to grant the authority to exclude or limit any pre-emptive ~~rights.~~rights until December 27, 2013. However, the General Meeting has limited this authority in a way that the Supervisory Board can only exclude or limit the pre-emptive rights in relation to no more than ~~50%~~20% of the aggregate number of ~~Common Shares~~all shares issued and ~~Financing Preference Shares available to be issued or rights to subscribe for those shares available to be granted~~outstanding in the capital of ~~our authorized but unissued share capital~~the Company as ~~of October 11, 2007. The authority to exclude or limit pre-emptive rights covers a period of 5 years commencing as of October 11, 2007.~~at December 31, 2011.

Acquisition of Our Own Shares

We may acquire our own shares, subject to certain provisions of Dutch law and our Articles, if (i) shareholders’ equity less the payment required to make the acquisition does not fall below the sum of paid-up and called-up capital and any reserves required by Dutch law or the Articles and (ii) we and our subsidiaries would not thereafter hold shares with an aggregate nominal value exceeding half of our issued share capital. Shares that we hold in our own capital or shares held by one of our subsidiaries may not be voted. The Managing Board, subject to the approval of the Supervisory Board, may effect our acquisition of shares in our own capital. Our acquisitions of shares in our own capital may only take place if the General Meeting has granted to the Managing Board the authority to effect such acquisitions. Such authority may apply for a maximum period of 5 years and must specify the number of shares that may be acquired, the manner in which shares may be acquired and the price limits within which shares may be acquired. Dutch corporate law allows for the authorisation of the Managing Board to purchase a number of shares equal to up to 50% of the Company’s issued share capital on the date of the acquisition. On June ~~30, 2010,~~27, 2012, the General Meeting resolved to extend the authorization of the Managing Board in such manner that the Managing Board may cause us to acquire shares in our own share capital, up to 10% of the outstanding shares, for an 18-month period beginning June ~~30, 2010~~27, 2012 until December ~~30, 2011,~~27, 2013, without limitation at a price between one Euro cent (Euro 0.01) and one hundred ten percent (110%) of the price for such shares on the NASDAQ Global Select Market for the five trading days prior to the day of purchase, or, with respect to Preference and Finance Preference shares, against a price between one Euro cent (Euro 0.01) and three times the issuance price and in accordance with applicable provisions of Dutch law and our Articles.

Capital Reduction

Subject to the provisions of Dutch law and our Articles, the General Meeting may, upon the proposal of the Supervisory Board, resolve to reduce the issued share capital by (i) canceling shares or (ii) reducing the nominal value of shares through an amendment of our Articles. Cancellation with repayment of shares or partial repayment on shares or release from the obligation to pay up may also be made or given exclusively with respect to Common Shares, Financing Preference Shares or Preference Shares.

Financial Year, Annual Accounts and Independent Registered Public Accounting Firm

Our financial year coincides with the calendar year. Dutch law and our Articles require that within four months after the end of the financial year, the Managing Board must make available a report with respect to such financial year, including our financial statements for such year prepared under International Financial Reporting Standards and accompanied by a report of an Independent Registered Public Accounting Firm. The annual report is submitted to the annual General Meeting for adoption.

The General Meeting appoints an Independent Registered Public Accounting Firm to audit the financial statements and to issue a report thereon. On June ~~30, 2011,~~27, 2012, our shareholders appointed Ernst & Young Accountants to serve as our Independent Registered Public Accounting Firm for the year ending December 31, ~~2011.~~2012.

Dividends and Other Distributions

Subject to certain exceptions, dividends may only be paid out of profits as shown in our annual financial statements as adopted by the General Meeting. Distributions may not be made if the distribution would reduce shareholders’ equity below the sum of the paid-up capital and any reserves required by Dutch law or our Articles.

Out of profits, dividends must first be paid on any outstanding Preference Shares (the Preference Share Dividend) in a

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percentage (the Preference Share Dividend Percentage) of the obligatory call amount paid up on such shares at the beginning of the financial year in respect of which the distribution is made. The Preference Share Dividend Percentage is equal to the average main refinancing rates during the financial year for which the distribution is made. Average main refinancing rate shall be understood to mean the average value on each individual day during the financial year for which the distribution is made of the main refinancing rates prevailing on such day. The main refinancing rate shall be understood to mean the rate of the Main Refinancing Operation as determined and published from time to time by the European Central Bank. If and to the extent that

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profits are not sufficient to pay the Preference Share Dividend in full, the deficit shall be paid out of the reserves, with the exception of any reserve, which was formed as share premium reserve upon the issue of Financing Preference Shares. If in any financial year the profit is not sufficient to make the distributions referred to above and if no distribution or only a partial distribution is made from the reserves referred to above, such that the deficit is not fully made good, no further distributions will be made as described below until the deficit has been made good.

Out of profits remaining after payment of any dividends on Preference Shares, the Supervisory Board shall determine such amounts as shall be kept in reserve as determined by the Supervisory Board. Out of any remaining profits not allocated to reserve, a dividend (the Financing Preference Share Dividend) shall be paid on the Financing Preference Shares equal to a percentage (the Financing Preference Share Dividend Percentage) over the nominal value of the Financing Preference Shares, increased by the amount of share premium that was paid upon the first issue of Financing Preference Shares. The Financing Preference Shares Dividend Percentage which percentage is related to a fixed average effective yield on the prime interest rate on corporate loans in the United States as quoted in the Wall Street Journal as set forth in article 40.4 of our Articles. If and to the extent that the profits are not sufficient to pay the Financing Preference Share Dividend in full, the deficit may be paid out of the reserves if the Managing Board so decides with the approval of the Supervisory Board, with the exception of the reserve which was formed as share premium upon the issue of Financing Preference Shares.

Insofar as the profits have not been distributed or allocated to reserves as specified above, the General Meeting may act to allocate such profits, provided that no further dividends will be distributed on the Preference Shares or the Financing Preference Shares.

The General Meeting may resolve, on the proposal of the Supervisory Board, to distribute dividends or reserves, wholly or partially, in the form of QIAGEN shares.

Distributions as described above are payable as from a date to be determined by the Supervisory Board. The date of payment on Type I shares may differ from the date of payment on Type II shares. Distributions will be made payable at an address or addresses in The Netherlands to be determined by the Supervisory Board, as well as at least one address in each country where the shares are listed or quoted for trading. The Supervisory Board may determine the method of payment of cash distributions, provided that cash distributions in respect of Type II shares will, subject to certain exceptions, be paid in the currency of a country where our shares are listed or quoted for trading, converted at the close of business on a day to be determined for that purpose by the Supervisory Board. Distributions in cash that have not been collected within five years and two days after they have become due and payable shall revert to QIAGEN.

Dutch law provides that the declaration of dividends out of the profits that are at the free disposal of the General Meeting is the exclusive right of the General Meeting. This is different from the corporate law of most jurisdictions in the United States, which permit a corporation’s board of directors to declare dividends.

Shareholder Meetings, Voting Rights and Other Shareholder Rights

The annual General Meeting is required to be held within six months after the end of each financial year for the purpose of, among other things, adopting the annual accounts and filling of any vacancies on the Managing and Supervisory Boards.

Extraordinary General Meetings are held as often as deemed necessary by the Managing Board or Supervisory Board, or upon the request of one or more shareholders and other persons entitled to attend meetings jointly representing at least 40% of our issued share capital or by one or more shareholders jointly representing at least 10% of our issued share capital as provided for and in accordance with the laws of The Netherlands.

General Meetings are held in Amsterdam, Haarlemmermeer (Schiphol Airport), Arnhem, Maastricht, Rotterdam, Venlo or The Hague. The notice convening a General Meeting must be given in such manner as shall be authorized by law including but not limited to an announcement published by electronic means no later than the forty-second day prior to day of the general meeting. The notice will contain the agenda for the meeting or state that the agenda can be obtained at our offices.

The agenda shall contain such subjects to be considered at the General Meeting, as the persons convening or requesting the meeting shall decide. Under Dutch law, holders of shares representing solely or jointly at least one hundredth part of the issued share capital, or representing a value of at least EUR 50,000,000 may request QIAGEN not later than on the sixtieth day

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prior to the day of the General Meeting, to include certain subjects on the notice convening a meeting ~~provided that it is not detrimental to the vital interest~~(this 1% or EUR 50,000,000 threshold will be amended into a 3% threshold, irrespective of the ~~company.~~value represented by such interest, pursuant to a bill entering into force as per the first July 1, 2013). No valid resolutions can be adopted at a General Meeting in respect of subjects which are not mentioned in the agenda.

Dutch corporate law sets a mandatory (participation and voting) record date for Dutch listed companies fixed at the

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twenty-eighth day prior to the day of the shareholders’ meeting. Shareholders registered at such record date are entitled to attend and exercise their rights as shareholders at the General Meeting, regardless of a sale of shares after the record date.

General Meetings are presided over by the chairman of the Supervisory Board or, in his absence, by any person nominated by the Supervisory Board.

At the General Meeting, each share shall confer the right to cast one vote, unless otherwise provided by law or our Articles. No votes may be cast in respect of shares that we or our subsidiaries hold, or by usufructuaries and pledgees. All shareholders and other persons entitled to vote at General Meetings are entitled to attend General Meetings, to address the meeting and to vote. They must notify the Managing Board in writing of their intention to be present or represented not later than on the third day prior to the day of the meeting, unless the Managing Board permits notification within a shorter period of time prior to any such meeting. Subject to certain exceptions, resolutions may be passed by a simple majority of the votes cast.

Except for resolutions to be adopted by the meeting of holders of Preference Shares, our Articles do not allow the adoption of shareholders resolutions by written consent (or otherwise without holding a meeting).

A resolution of the General Meeting to amend our Articles, dissolve QIAGEN, issue shares or grant rights to subscribe for shares or limit or exclude any pre-emptive rights to which shareholders shall be entitled is valid only if proposed to the General Meeting by the Supervisory Board.

A resolution of the General Meeting to amend our Articles is further only valid if the complete proposal has been made available for inspection by the shareholders and the other persons entitled to attend General Meetings at our offices as from the day of notice convening such meeting until the end of the meeting. A resolution to amend our Articles to change the rights attached to the shares of a specific class requires the approval of the relevant class meeting.

Resolutions of the General Meeting in a meeting that has not been convened by the Managing Board and/or the Supervisory Board, or resolutions included on the agenda for the meeting at the request of shareholders, will be valid only if adopted with a majority of two-thirds of votes cast representing more than half the issued share capital, unless our Articles require a greater majority or quorum. Our Articles do not provide for shareholders to act by written consent outside of a General Meeting.

A resolution of the General Meeting to approve a legal merger or the sale of all or substantially all of our assets is valid only if adopted by a vote of at least two-thirds of the issued share capital, unless proposed by the Supervisory Board, in which case a simple majority of the votes cast shall be sufficient.

A shareholder shall upon request be provided, free of charge, with written evidence of the contents of the share register with regard to the shares registered in its name. Furthermore, any shareholder shall, upon written request, have the right, during normal business hours, to inspect our share register and a list of our shareholders and their addresses and shareholdings, and to make copies or extracts therefrom. Such request must be directed to our Managing Directors at our registered office in the Netherlands or at our principal place of business. Financial records and other company documents (other than those made public) are not available in this manner for shareholder review, but an extract of the minutes of the General Meeting shall be made available.

According to Dutch law and our Articles, certain resolutions of the Managing Board regarding a significant change in the identity or nature of us or our enterprise are subject to the approval of the General Meeting. The following resolutions of the Managing Board require the approval of the General Meeting in any event:


(i)	the transfer of our enterprise or practically our entire enterprise to a third party;


(ii)	the entry into or termination of a long-term cooperation by us or one of our subsidiaries (dochtermaatschappijen) with another legal person or partnership or as a fully liable general partner of a limited partnership or a general partnership, if such cooperation or termination is of a far-reaching significance for us; and


(iii)	the acquisition or divestment by us or one of our subsidiaries (dochtermaatschappijen) of a participating interest in the capital of a company with a value of at least one-third of the sum of our assets according to our consolidated balance sheet and explanatory notes in our last adopted annual accounts.

No Derivative Actions; Right to Request Independent Inquiry

Dutch law does not afford shareholders the right to institute actions on behalf of us or in our interest. Shareholders

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holding at least ~~one-tenth~~one-hundredth of our issued capital, or EUR ~~225,000,~~20,000,000, in ~~nominal amount~~market value of our shares may inform the Managing Board and the Supervisory Board of their objections as to our policy or the course of our affairs and, within a reasonable time thereafter, may request the Enterprises Division of the Court of Appeal in Amsterdam to order an inquiry into

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the policy and the course of our affairs by independent investigators. If such an inquiry is ordered and the investigators conclude that there has been mismanagement, the shareholders can request the Division to order certain measures such as a suspension or annulment of resolutions.

Dissolution and Liquidation

The General Meeting may resolve to dissolve QIAGEN. If QIAGEN is dissolved, the liquidation shall be carried out by the person designated for that purpose by the General Meeting, under the supervision of the Supervisory Board. The General Meeting shall upon the proposal of the Supervisory Board determine the remuneration payable to the liquidators and to the person responsible for supervising the liquidation.

During the liquidation process, the provisions of our Articles will remain applicable to the extent possible.

In the event of our dissolution and liquidation, the assets remaining after payment of all debts and liquidation expenses will be distributed among registered holders of Common Shares in proportion to the nominal value of their Common Shares, subject to liquidation preference rights of holders of Preference Shares and Financing Preference Shares, if any.

Restrictions on Transfer of Preference Shares

The Supervisory Board, upon application in writing, must approve each transfer of Preference Shares. If approval is refused, the Supervisory Board will designate prospective purchasers willing and able to purchase the shares, otherwise the transfer will be deemed approved.

Limitations in our Articles on Rights to Own Securities

Other than with respect to usufructuaries and pledgees who have no voting rights, our Articles do not impose limitations on rights to own our securities.

Provisions which May Defer or Prevent a Change in Control

The Option Agreement and our Articles could, under certain circumstances, prevent a third party from obtaining a majority of the voting control of our shares by issuing Preference Shares. Pursuant to the Articles (and pursuant to the resolution adopted by our General Meeting on June 16, 2004), the Supervisory Board is authorized to issue Preference Shares if (i) a person has (directly or indirectly) acquired or has expressed a desire to acquire, more than 20% of our issued capital or (ii) a person holding at least a 10% interest in us has been designated as an “adverse person” by the Supervisory Board. Under the Option Agreement, SPAQ could acquire Preference Shares subject to the provisions mentioned in this paragraph.

If the Supervisory Board opposes an intended take-over and authorizes the issuance of Preference Shares, the bidder may withdraw its bid or enter into negotiations with the Managing Board and/or Supervisory Board and agree on a higher bid price for our shares.

Due to the implementation of the EC Directive or Takeover Bids, or 13th Directive, in Dutch legislation, shareholders who obtain control of a company are obliged to make a mandatory offer to all other shareholders. The threshold for a mandatory offer is set at the ability to exercise 30% of the voting rights at the General Meeting of shareholders in a Dutch public limited company (naamloze vennootschap) whose securities are admitted to trading on a regulated market in the EU, such as QIAGEN.

Ownership Threshold Requiring Disclosure

Our Articles do not provide an ownership threshold above which ownership must be disclosed. However there are statutory requirements to disclose share ownership above certain thresholds under Dutch law—see “Obligation of Shareholders to Disclose Major Holdings.”

Exchange Controls

There are currently no limitations either under the laws of The Netherlands or in our Articles, to the rights of shareholders from outside The Netherlands to hold or vote Common Shares. Under current foreign exchange regulations in The Netherlands, there are no material limitations on the amount of cash payments that we may remit to residents of foreign countries.

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Obligation of Shareholders to Disclose Major Holdings

Certain holders of our shares or rights to acquire shares (which include options and convertible ~~bonds)~~bonds - see also below) are subject to notification obligations under Chapter 5.3 of the Dutch Financial Markets Supervision Act, or the FMSA.

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Under Chapter 5.3 of the FMSA, any person who, directly or indirectly, acquires or disposes of an interest (including potential interest, such as options and convertible bonds), in our capital or voting rights must immediately notify the Netherlands Authority for the Financial Markets, or AFM, by means of a standard form, if as a result of such acquisition or disposal, the percentage of capital interest or voting rights held by such person in QIAGEN reaches, exceeds or falls below any of the following thresholds: 5% ~~(a bill is being considered that would add a threshold of 3%)~~, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 75% and 95% (as per July 1, 2013, a bill will enter into force adding 3% threshold) of the voting rights or capital interests in the issued capital of QIAGEN. A notification requirement also applies if a ~~person’s~~person's capital interest or voting rights reach, exceed or fall below the above mentioned thresholds as a result of a change in our total share capital or voting rights. Such notification has to be made no later than the fourth trading day after the AFM has published our notification as described below. We are required to notify the AFM immediately of the changes to our total share capital or voting rights if our share capital or voting rights changes by 1% or more since our previous notification. We must furthermore quarterly notify the AFM within eight days after the end of the relevant quarter, in the event our share capital or voting rights changed by less than 1% in that relevant quarter since our previous notification.

Furthermore, every holder of 5% ~~(a bill is being considered that would add a threshold of 3%)~~ or more of our share capital or voting rights whose interest at December 31 at midnight differs from a previous notification to the AFM, as a result of certain acts (including but not limited to the exchange of our shares for depository receipts and the exercise of a right to acquire our shares) must notify the AFM within four ~~weeks.~~weeks (as per July 1, 2013, a bill will enter into force reducing this threshold to 3%). Controlled entities, within the meaning of the FMSA, do not have notification obligations under the FMSA, as their direct and indirect interests are attributed to their (ultimate) parent. Any person may qualify as a parent for purposes of the FMSA, including an individual. A person who has a 5% (a(as per July 1, 2013, a bill ~~is being considered that would reduce~~will enter into force reducing this threshold to 3%) or larger interest in our share capital or voting rights and who ceases to be a controlled entity for these purposes must immediately notify the AFM. As of the date of that notification, all notification obligations under the FMSA will become applicable to that entity. For the purpose of calculating the percentage of capital interest or voting rights, among other metrics, the following interests must be taken into account: (i) our shares or voting rights on our shares directly held (or acquired or disposed of) by a person, (ii) our shares or voting rights on our shares held (or acquired or disposed of) by such ~~person’s~~person's subsidiaries or by a third party for such ~~person’s~~person's account or by a third party with whom such person has concluded an oral or written voting agreement (including a discretionary power of attorney), and (iii) our shares or voting rights on our shares which such person, or any subsidiary or third party referred to above, may acquire pursuant to any option or other right held by such person (or acquired or disposed of, including, but not limited to, on the basis of convertible bonds). Special rules apply with respect to the attribution of our shares or voting rights on our shares which are part of the property of a partnership or other community of property. A holder of a pledge or right of usufruct (vruchtgebruik) in respect of our shares can also be subject to the notification obligations of the FMSA, if such person has, or can acquire, the right to vote on our shares or, in the case of depository receipts, our underlying shares. The acquisition of (conditional) voting rights by a pledgee or usufructuary may also trigger the notification obligations as if the pledgee or beneficial owner were the legal holder of our shares or voting rights on our shares. A holding in certain cash settled derivatives (such as cash settled call options and total equity return swaps) referencing to our shares should also be taken into account for the purpose of calculating the percentage of capital interest.

As per July 1, 2013 a bill will enter into force that provides for an notification obligation with regard to a (gross) short position exceeding a threshold of 3, 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 75% or 95%.

The AFM does not issue separate public announcements of these notifications. It does, however, keep a public register of all notifications under the FMSA on its website www.afm.nl. Third parties can request to be notified automatically by e-mail of changes to the public register in relation to a particular company’s shares or a particular notifying party.

Non-compliance with the notification obligations under the FMSA may lead to criminal fines, administrative fines, imprisonment or other sanctions. In addition, non-compliance with the shareholding disclosure obligations under the FMSA may lead to civil sanctions, including suspension of the voting rights relating to our shares held by the offender for a period of not more than three years and a prohibition applicable to the offender to acquire any of our shares or voting rights on our shares for a period of up to five years.

Taxation

The following is a general summary of certain material United States federal income and The Netherlands tax consequences to holders of our Common Shares (collectively, “U.S. Holders”) who are (i) citizens or residents of the United States, (ii) entities subject to U.S. corporate tax, (iii) certain pension trusts and other retirement or employee benefits organizations established in the United States but generally exempt from U.S. tax, (iv) certain not-for-profit organizations established in the United States but generally exempt from U.S. tax, (v) United States regulated investment companies, United States real estate investment trusts, and United States real estate mortgage conduits, and (vi) partnerships or similar ~~pass-~~

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~~through~~pass-through entities, estates, and trusts to the extent the income of such partnerships, similar entities, estates, or trusts is subject to

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tax in the United States as income of a resident in its hands or the hands of its partners, beneficiaries, or grantors. This summary does not discuss every aspect of such taxation that may be relevant to U.S. Holders. Therefore, all prospective purchasers of our Common Shares who would be U.S. Holders are advised to consult their own tax advisor with respect to the United States federal, state and local tax consequences, as well as the Netherlands tax consequences, of the ownership of our Common Shares. This summary is based upon the advice of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. with respect to tax consequences for U.S. Holders under United States Law and Baker & McKenzie with respect to tax consequences under Netherlands law.

The statements of The Netherlands and United States tax laws set out below are based on the laws in force as of the date of this Annual Report on Form 20-F, and as a consequence are subject to any changes in United States or The Netherlands law, or in the double taxation conventions between the United States and The Netherlands, occurring after such date.

Netherlands Tax Considerations

The following describes the material tax consequences under Netherlands law of an investment in our Common Shares. Such description is based on current Netherlands law as interpreted under officially published case law, and is limited to the tax implications for an owner of our Common Shares who is not, or is not deemed to be, a resident of The Netherlands for purposes of the relevant tax codes (a “non-resident Shareholder” or “Shareholder”).

Dividend Withholding Tax

General. Upon distribution of dividends, we would be obligated to withhold 15% dividend tax at source and to pay the amount withheld to The Netherlands tax authorities. The term “dividends” means income from shares or other rights participating in profits, as well as income from other corporate rights that is subjected to the same taxation treatment as income from shares by the laws of The Netherlands. Dividends include dividends in cash or in kind, constructive dividends, certain repayments of capital qualified as dividends, interest on loans that are treated as equity for Netherlands corporate income tax purposes and liquidation proceeds in excess of, for Netherlands tax purposes, recognized paid-in capital. Stock dividends are also subject to withholding tax, unless derived from our paid-in share premium which is recognized as equity for Netherlands tax purposes.

No withholding tax applies on the proceeds resulting from the sale or disposition of our Common Shares to persons other than QIAGEN and our affiliates.

A Shareholder can be eligible for a reduction or a refund of Netherlands dividend withholding tax under a tax convention which is in effect between the country of residence of the Shareholder and The Netherlands. The Netherlands has concluded such conventions with, among others, the United States, Canada, Switzerland, Japan and virtually all EU Member States.

U.S. Shareholders. Under the Tax Convention between The Netherlands and the United States (the “Convention”), the regular 15% withholding tax on dividends we pay to a resident of the United States (as defined in the Convention) who is entitled to the benefits of the Convention, may be reduced to 5% (in the case of a corporate U.S. Shareholder that holds 10% or more of the voting power of a Netherlands company) unless such U.S. shareholder has a permanent establishment in The Netherlands with which the shares are effectively connected.

A full exemption from Netherlands withholding tax may apply to certain U.S. corporate shareholders owning at least 80% of QIAGEN voting power for a period of at least twelve months prior to the distribution.

Dividends we pay to U.S. pension funds and U.S. tax exempt organizations may be eligible for an exemption from dividend withholding tax.

Dividend Stripping. A refund, reduction, exemption, or credit of Netherlands dividend withholding tax on the basis of Netherlands tax law or on the basis of a tax treaty between The Netherlands and another state, will only be granted if the dividends are paid to the beneficial owner (“uiteindelijk gerechtigde”) of the dividends. A recipient of a dividend is not considered to be the beneficial owner of a dividend in an event of “dividend stripping,” in which he has paid a consideration related to the receipt of such dividend. In general terms, “dividend stripping” can be described as the situation in which a foreign or domestic person (usually, but not necessarily, the original shareholder) has transferred his shares or his entitlement to the dividend distributions to a party that has a more favorable right to a refund or reduction of Netherlands dividend withholding tax than the foreign or domestic person. In these situations, the foreign or domestic person (usually the original shareholder) avoids Netherlands dividend withholding tax while retaining his “beneficial” interest in the shares and the dividend distributions, by transferring his shares or his entitlement to the dividend distributions.

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Income Tax and Corporate Income Tax

General. A non-resident Shareholder will not be subject to Netherlands income tax or corporate income tax with respect to dividends we distribute on our Common Shares or with respect to capital gains derived from the sale or disposition of our Common Shares, provided that:

(a) the non-resident Shareholder has not made an election for the application of the rules of The Netherlands 2001 Income Tax Act as they apply to residents of The Netherlands;

(b) the non-resident Shareholder does not carry on or have an interest in a business in The Netherlands through a permanent establishment or a permanent representative to which or to whom the Common Shares are attributable or deemed to be attributable;

(c) the non-resident Shareholder does not have a direct or indirect substantial or deemed substantial interest (“aanmerkelijk belang,” as defined in the Netherlands tax code) in our share capital or, in the event the Shareholder does have such a substantial interest, such interest is a “business asset”;, or, in case of a corporate Shareholder, such interest is a "business asset" or not held with the main purpose or one of the main purposes to avoid Dutch income tax or dividend tax for another person; and

(d) the non-resident Shareholder is not entitled to a share in the profits of an enterprise, to which our Common Shares are attributable and that is effectively managed in The Netherlands, other than by way of securities or through an employment contract.

In general terms, a substantial interest (“aanmerkelijk belang”) in our share capital does not exist if the Shareholder (individuals as well as corporations), alone or together with his partner, does not own, directly or indirectly, 5% or more of the nominal paid-in capital of, or any class of our shares, does not have the right to acquire 5% or more of the nominal paid-in capital of, or any class of our shares (including a call option) and does not have the right to share in our profit or liquidation revenue amounting to 5% or more of the annual profits or liquidation revenue.

There is no all-encompassing definition of the term “business asset”; whether this determination can be made in general depends on the facts presented and in particular on the activities performed by the Shareholder. If the Shareholder materially conducts a business activity, while the key interest of his investment in our Shares will not be his earnings out of the investment in our Shares but our economic activity, an investment in our Shares will generally be deemed to constitute a business asset, in particular if the Shareholder’s involvement in our business will exceed regular monitoring of his investment in our Shares.

U.S. Shareholders. Pursuant to the Convention, the gain derived by a U.S. Shareholder from an alienation of our Common Shares constituting a substantial interest of the Shareholder in QIAGEN, not effectively connected or deemed connected with a permanent establishment or permanent representative of the Shareholder in The Netherlands, is not subject to Netherlands income tax or corporate income tax, provided that the gain from the alienation of our Common Shares is not derived by an individual Shareholder who has, at any time during the five-year period preceding such alienation, been a resident of The Netherlands according to Netherlands tax law and who owns, at the time of the alienation, either alone or together with close relatives, at least 25% of any class of our shares.

Gift and Inheritance Tax

A gift or inheritance of our Common Shares from a non-resident Shareholder will generally not be subject to a Netherlands gift and inheritance tax, provided that the Shareholder does not own a business which is, in whole or in part, carried on through a permanent establishment or a permanent representative in The Netherlands to which or to whom our Common Shares are attributable. The Netherlands has concluded a tax convention with the United States based on which double taxation on inheritances may be avoided if the inheritance is subject to Netherlands and/or U.S. inheritance tax and the deceased was a resident of either The Netherlands or the United States.

United States Federal Income Tax Considerations

The following summarizes the material U.S. federal income tax consequences of the ownership of our Common Shares by an investor that purchases such Common Shares and that will hold the Common Shares as capital assets. This summary does not purport to be a complete analysis or listing of all potential tax considerations and does not address holders subject to special treatment under U.S. federal income tax laws (including insurance companies, tax-exempt organizations, regulated investment companies, financial institutions, broker dealers or holders that own, actually or constructively, 10% or more of our voting shares).

As used herein, references to a “U.S. Holder” are to a holder of our Common Shares that is (i) a citizen or resident for tax purposes of the United States, (ii) a corporation organized under the laws of the United States or any political subdivision

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thereof, or (iii) a person or entity otherwise subject to United States federal income taxation on a net income basis with respect to our Common Shares (including a non-resident alien or foreign corporation that holds, or is deemed to hold, our Common Shares in

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connection with the conduct of a U.S. trade or business); and references to a “non-U.S. Holder” are to a holder that is not a U.S. person for U.S. federal income tax purposes.

Taxation of Dividends

To the extent paid out of our current or accumulated earnings and profits, as determined under U.S. federal income tax principles, distributions, if any, made with respect to our Common Shares will be includable for U.S.

federal income tax purposes in the income of a U.S. Holder as ordinary dividend income in an amount equal to the sum of any cash and the fair market value of any property that we distribute, before reduction for Netherlands withholding tax. ~~For tax years beginning before 2013, such~~Such dividends will be eligible to be treated by U.S. Holder individuals, trusts and estates as “qualified dividend income” subject to a maximum tax rate of 1520 percent (plus possibly an additional 3.8 percent on net investment income), if the shareholder receiving the dividend satisfies the holding period requirements, and if we are not treated for our taxable year in which the dividend is paid, or our preceding taxable year, as a passive foreign investment company (see “Taxation—United States Federal Income Tax Considerations—Passive Foreign Investment Company Status”). To the extent that such distribution exceeds our current or accumulated earnings and profits, it will be treated as a non-taxable return of capital to the extent of the U.S. Holder’s adjusted tax basis in our Common Shares and thereafter as taxable capital gain. Dividends generally will be treated as income from sources outside the United States and generally will be passive income (or, in the case of certain holders, “financial services income”) for purposes of the foreign tax credit limitation. Dividends we pay will not be eligible for the dividends received deduction allowed to corporations in certain circumstances under the United States Internal Revenue Code of 1986, as amended (the Code). A U.S. Holder may elect annually to either deduct The Netherlands withholding tax (see “Taxation—Netherlands Tax Considerations—Dividend Withholding Tax”) against their income (in which case, the election will apply to all foreign income taxes such U.S. Holder paid in that year) or take the withholding taxes as a credit against their U.S. tax liability, subject to U.S. foreign tax credit limitation rules. If the dividends are qualified for the lower applicable capital gains rate (as discussed ~~in the above paragraph)~~above), the amount of the dividend income taken into account for calculating the foreign tax credit limitation will in general be limited to the gross amount of the dividend, multiplied by the reduced rate, divided by the highest rate of tax normally applicable to dividends. The rules governing the foreign tax credit are complex. We urge you to consult with your own tax advisors regarding the availability of the foreign tax credit in your particular circumstances.

Dividends we pay in a currency other than the U.S. dollar will be included in the income of a U.S. Holder in a U.S. dollar amount based upon the exchange rate in effect on the date of receipt. A U.S. Holder will have a tax basis in such foreign currency for U.S. federal income tax purposes equal to its U.S. dollar value on the date of receipt. Any gain or loss on a subsequent disposition of such foreign currency (including a subsequent conversion into U.S. dollars) will be ordinary income or loss. Such gain or loss will generally be income from sources within the U.S. for foreign tax credit limitation purposes.

A non-U.S. Holder generally will not be subject to U.S. federal income tax or withholding tax on distributions with respect to our Common Shares that are treated as dividend income for U.S. federal income tax purposes unless such dividends are effectively connected with the conduct of a trade or business within the United States by such non-U.S. Holder, (and are attributable to a permanent establishment maintained in the United States by such non-U.S. Holder, if an applicable income tax treaty so requires as a condition for such non-U.S. Holder to be subject to U.S. taxation on a net income basis in respect of income from our Common Shares), in which case the non-U.S. Holder generally will be subject to tax in respect of such dividends in the same manner as a U.S. Holder. Any such effectively connected dividends received by a non-United States corporation may also, under certain circumstances, be subject to an additional “branch profits tax” at a 30% rate or such lower rate as may be specified by an applicable income tax treaty. A non-U.S. Holder generally will not be subject to U.S. federal income tax or withholding tax on distributions with respect to our Common Shares that are treated as capital gain for U.S. federal income tax purposes unless such holder would be subject to U.S. federal income tax on gain realized on the sale or other disposition of our Common Shares, as discussed below.

Taxation of Capital Gains

Subject to the PFIC rules discussed below, upon the sale or other disposition of our Common Shares, a U.S. Holder will recognize gain or loss for U.S. federal income tax purposes in an amount equal to the difference between the amount realized on the disposition of our Common Shares and the U.S. Holder’s adjusted tax basis in our Common Shares. Such gain or loss generally will be subject to U.S. federal income tax. An individual U.S. Holder is generally subject to a maximum capital gains rate of ~~15%~~20% for ~~tax years beginning before 2013 for~~ our

Common Shares held for more than a year. For U.S. federal income tax purposes, capital losses are subject to limitations on deductibility. Gain realized by a U.S. Holder on the sale or other disposition of our Common Shares generally will be treated as income from sources within the United States for purposes of the foreign tax credit limitation.

A non-U.S. Holder will not be subject to U.S. federal income tax or withholding tax on gain realized on the sale or other

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disposition of our Common Shares unless (i) the gain is effectively connected with a trade or business of the non-U.S. Holder

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in the United States (and is attributable to a permanent establishment maintained in the United States by such non-U.S. Holder, if an applicable income tax treaty so requires as a condition for such non-U.S. Holder to be subject to U.S. taxation on a net income basis in respect of gain from the sale or other disposition of our Common Shares) or (ii) such holder is an individual who is present in the United States for 183 days or more in the taxable year of the sale, and certain other conditions are met. Effectively connected gains realized by a corporate Non-U.S. Holder may also, under certain circumstances, be subject to an additional “branch profits tax” at a 30% rate or such lower rate as may be specified by an applicable income tax treaty.

Passive Foreign Investment Company Status

We may be classified as a “passive foreign investment company” (“PFIC”) for U.S. federal income tax purposes if certain tests are met. We will be a PFIC with respect to a U.S. Holder if for any taxable year in which the U.S. Holder held our Common Shares, either (i) 75% or more of our gross income for the taxable year is passive income; or (ii) the average value of our assets (during the taxable year) which produce or are held for the production of passive income is at least 50% of the average value of all assets for such year. Passive income means, in general, dividends, interest, royalties, rents (other than rents and royalties derived in the active conduct of a trade or business and not derived from a related person), annuities, and gains from assets which would produce such income other than sales of inventory. For the purpose of the PFIC tests, if a foreign corporation owns at least 25% by value of the stock of another corporation, the foreign corporation is treated as owning its proportionate share of the assets of the other corporation, and as if it had received directly its proportionate share of the income of such other corporation. The effect of this special provision with respect to QIAGEN and our ownership of our subsidiaries is that we, for purposes of the income and assets tests described above, will be treated as owning directly our proportionate share of the assets of our subsidiaries and of receiving directly our proportionate share of each of those companies’ income, if any, so long as we own, directly or indirectly, at least 25% by value of the particular company’s stock. Active business income of our subsidiaries will be treated as our active business income, rather than as passive income. Based on our income, assets and activities, we do not believe that we were a PFIC for our taxable years ended December 31, ~~2010~~2011 and December 31, ~~2011~~2012 and do not expect to be a PFIC for the current taxable year. No assurances can be made, however, that the IRS will not challenge this position or that we will not subsequently become a PFIC. Following the close of any tax year, we intend to promptly send a notice to all shareholders of record at any time during such year, if we determine that we are a PFIC.

Prospective purchasers of our Common Shares are urged to consult their tax advisors regarding the PFIC rules and their effect on an investment in our Common Shares, with particular regard to (i) the advisability of making the qualified election in the event that we notify the shareholders that we have become a PFIC in any taxable year, or (ii) the advisability of making the mark-to-market election provided in the tax law.

Backup Withholding and Information Reporting

In general, dividend payments, or other taxable distributions, paid within the United States or through certain U.S.-related financial intermediaries on our Common Shares will be subject to information reporting requirements and backup withholding tax at the rate of 28% for a non-corporate United States person and, who also:

fails to provide an accurate taxpayer identification number;

is notified by the Internal Revenue Service that the individual has failed to report all interest or dividends required to be shown on the Federal income tax returns; or

in certain circumstances, fails to comply with applicable certification requirements.

Certain corporations and persons that are not United States persons may be required to establish their exemption from information reporting and backup withholding by certifying their status on Internal Revenue Service Form W-8 or W-9.

If a United States person sells our Common Shares to or through a United States office of a broker, the payment of the proceeds is subject to both United States backup withholding and information reporting unless the individual can certify that they are a non-U.S. person, under penalties of perjury, or they otherwise establish an exemption. If a United States person sells our Common Shares through a non-U.S. office of a non-U.S. broker and the sale proceeds are paid to the person outside the United States then information reporting and backup withholding generally will not apply to that payment. However, United States information reporting requirements, but not backup withholding, will apply to a payment of sales proceeds, even if that payment is made to the United States person outside the United States, if the person sells our Common Shares through a non-U.S. office of a broker that is a U.S. person or has certain other contacts with the United States.

A Holder generally may obtain a refund of any amounts withheld under the backup withholding rules that exceed such holder’s income tax liability by filing a refund claim with the United States Internal Revenue Service.

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Foreign Currency Issues

If dividends are paid in euros, the amount of the dividend distribution included in the income of a U.S. Holder will be the U.S. dollar value of the payments made in euros, determined at a spot, euro/U.S. dollar rate applicable to the date such dividend is includible in the income of the U.S. Holder, regardless of whether the payment is in fact converted into U.S. dollars. Generally, gain or loss (if any) resulting from currency exchange fluctuations during the period from the date the dividend is paid to the date such payment is converted into U.S. dollars will be treated as ordinary income or loss. We have never paid cash dividends on our share capital and do not intend to do so for the foreseeable future.

Certain Information Reporting Requirements

Individuals who are U.S. Holders, and who hold “specified foreign financial assets” (as defined in section 6038D of the Code), including stock of a non-U.S. corporation that is not held in an account maintained by a U.S. “financial institution” (as defined in section 6038D of the Code), whose aggregate value exceeds $50,000 during the tax year, may be required to attach to their tax returns for the year certain specified information (Form 8938). An individual who fails to timely furnish the required information may be subject to a penalty, unless the failure is shown to be due to reasonable cause and not due to willful neglect. Additionally, in the event a U.S. Holder does not file such a report, the statute of limitations on the assessment and collection of U.S. federal income taxes of such U.S. Holder for the related tax year may not close before such report is filed. Under certain circumstances, an entity may be treated as an individual for purposes of the foregoing rules. U.S. holder (including entities) should consult their own tax advisors regarding their reporting obligations under this legislation.

Documents on Display

Documents referred to in this Annual Report may be inspected at our principal executive office located at Spoorstraat 50, 5911 KJ Venlo, The Netherlands.


Item 11.	Quantitative and Qualitative Disclosures About Market Risk

Our market risk relates primarily to interest rate exposures on cash, short-term investments and borrowings and foreign currency exposures. Financial risk is centrally managed and is regulated by internal guidelines which require a continuous internal risk analysis. The overall objective of our risk management is to reduce the potential negative earnings effects from changes in interest and foreign exchange rates. Exposures are managed through operational methods and financial instruments relating to interest rate and foreign exchange risks. In the ordinary course of business, we use derivative instruments, including swaps, forwards and/or options, to manage potential losses from foreign currency exposures and variable rate debt. The principal objective of such derivative instruments is to minimize the risks and/or costs associated with global financial and operating activities. We make use of ‘economic hedges’, i.e. derivatives that do not have a formally designated hedging relationship as well as ‘accounting hedges’. All derivatives that qualify for hedge accounting are ‘cash-flow hedges’. We do not utilize derivative or other financial instruments for trading or other speculative purposes. All derivatives are recognized as either assets or liabilities in the balance sheet and are measured at fair value with any change in fair value recognized in earnings in the period of change, unless the derivative qualifies as an effective hedge that offsets certain exposures. In determining fair value, we consider both the counterparty credit risk and our own creditworthiness.

Foreign Currency Derivatives. As a globally active enterprise, we are subject to risks associated with fluctuations in foreign currencies in our ordinary operations. This includes foreign currency-denominated receivables, payables, debt, and other balance sheet positions. We manage our balance sheet exposure on a group-wide basis primarily using foreign exchange forward contracts, options and cross-currency swaps.

Interest Rate Derivatives. We have used interest rate derivative contracts on certain borrowing transactions to hedge fluctuating interest rates. We previously entered into interest rate swaps in which we agreed to exchange, at specified intervals, the difference between fixed and floating interest amounts calculated by reference to an agreed-upon notional principal amount. These interest rate derivatives matured in 2011.

We make use of ‘economic hedges’, i.e. derivatives that do not have a formally designated hedging relationship as well as ‘accounting hedges’. All derivatives that qualify for hedge accounting are ‘cash-flow hedges’. Further details of our derivative and hedging activities can be found in Note 713 to the accompanying consolidated financial statements.

Interest Rate Risk

At December 31, ~~2011,~~2012, we had $~~221.1~~394.0 million in cash and cash equivalents as well as $~~54.6~~90.5 million in short-term investments. Interest income earned on our cash investments is affected by changes in the relative levels of market interest rates. We only invest in high-grade investment instruments. A hypothetical adverse 10% movement in market interest rates would ~~decrease 2011 earnings by approximately $0.4 million.~~not have materially impacted our financial statements.

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Borrowings against lines of credit are at variable interest rates. We had ~~$142.3 million~~no amounts outstanding against our lines of

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credit at December 31, ~~2011.~~2012. A hypothetical adverse 10% movement in market interest rates would not have materially impacted our financial statements.

At December 31, ~~2011,~~2012, we had $~~447.6~~847.0 million in long-term debt, none of which is at a variable rate. A hypothetical adverse 10% movement in market interest rates would not have materially impacted our financial statements.

Foreign Currency Exchange Rate Risk

As a global enterprise, we are subject to risks associated with fluctuations in foreign currencies with regard to our ordinary operations. This includes foreign currency-denominated receivables, payables, debt, and other balance sheet positions as well as future cash flows resulting from anticipated transactions including intra-group transactions.

A significant portion of our revenues and expenses are earned and incurred in currencies other than the U.S. dollar. The euro is the most significant such currency, with others including the British pound, Japanese yen, Chinese renminbi, Swiss franc, and Canadian and Australian dollars. Fluctuations in the value of the currencies in which we conduct our business relative to the U.S. dollar have caused and will continue to cause U.S. dollar translations of such currencies to vary from one period to another. Due to the number of currencies involved, the constantly changing currency exposures, and the potential substantial volatility of currency exchange rates, we cannot predict the effect of exchange rate fluctuations upon future operating results. In general terms, depreciation of the U.S. dollar against our other foreign currencies will increase reported net sales. However, this effect is, at least partially, offset by the fact that we also incur substantial expenses in foreign currencies.

We have significant production and manufacturing facilities located in Germany and Switzerland, and intercompany sales of inventory also expose us to foreign currency exchange rate risk. Intercompany sales of inventory are generally denominated in the local currency of the subsidiary purchasing the inventory in order to centralize foreign currency risk with the manufacturing subsidiary. ~~Payment for~~We use an in-house bank approach to net and settle intercompany ~~purchases of inventory is required within 30 days from invoice date. The delay between~~payables and receivables as well as intercompany foreign exchanged swaps and forward contracts in order to centralize the ~~date the manufacturing subsidiaries record revenue and the date when the payment is received from the purchasing subsidiaries exposes us to~~ foreign exchange ~~risk. To~~rate risk to the extent ~~practicable, such exposures are offset by operational measures, which include intercompany factoring transactions.~~possible. We have entered ~~into~~ in the past and may enter ~~into~~ in the future into foreign exchange derivatives including ~~forward contracts~~forwards, swaps and options to manage the remaining foreign exchange ~~risk.~~exposure.


Item 12.	Description of Securities Other than Equity Securities

Not applicable.

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PART II


Item 13.	Defaults, Dividend Arrearages and Delinquencies

Not applicable.


Item 14.	Material Modifications to the Rights of Security Holders and Use of Proceeds

Not applicable.


Item 15.	Controls and Procedures

Disclosure Controls and Procedures

Our Managing Directors, with the assistance of other members of management, performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures, as that term is defined in Rules 13a-15(e) and 15d-15(e) of the Securities Exchange Act of 1934, as amended, within 90 days of the date of this report. Based on that evaluation, they concluded that as of December 31, ~~2011,~~2012, our disclosure controls and procedures were effective to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms, and is accumulated and communicated to our management, including our Managing Directors, as appropriate to allow timely decisions regarding required disclosure.

There are inherent limitations to the effectiveness of any system of disclosure controls and procedures, no matter how well designed, such as the possibility of human error and the circumvention or overriding of the controls and procedures. Therefore, even those systems determined to be effective may not prevent or detect misstatements and can provide only reasonable assurance of achieving their control objectives. In addition, any determination of effectiveness of controls is not a projection of any effectiveness of those controls to future periods, as those controls may become inadequate because of changes in conditions or the degree of compliance with the policies or procedures may deteriorate.

Report of Management on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rules 13a-15(f) and 15d-15(f) under the Securities Exchange Act of 1934, as amended. The Company’s system of internal controls over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of the consolidated financial statements in accordance with generally accepted accounting principles.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements and even when determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation. Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Our management assessed the effectiveness of the Company’s internal control over financial reporting as of December 31, ~~2011.~~2012. In making this assessment, management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated Framework.

Based on our assessment under the COSO Internal Control-Integrated Framework, management believes that, as of December 31, ~~2011,~~2012, our internal control over financial reporting is effective. Securities and Exchange Commission guidelines permit companies to exclude acquisitions from their assessment of internal control over financial reporting during the first year following an acquisition.

Attestation Report of the Independent Registered Public Accounting Firm

Ernst & Young GmbH Wirtschaftsprüfungsgesellschaft, the independent registered public accounting firm that audited our consolidated financial statements, has audited the effectiveness of the Company's internal control over financial reporting as of December 31, ~~2011.~~2012. Their report is included in this Annual Report on Form 20-F on page F-2.

Changes in Internal Control over Financial Reporting

There has been no change in our internal control over financial reporting during ~~2011~~2012 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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Item 16A.	Audit Committee Financial Expert

The Supervisory Board has designated Dr. Werner Brandt as an “audit committee financial expert” as that term is defined in the SEC rules adopted pursuant to the Sarbanes-Oxley Act. Dr. Brandt is “independent” as defined in the Marketplace Rules of the NASDAQ as applicable to Audit Committees.


Item 16B.	Code of Ethics

QIAGEN has in place a Code of Conduct which qualifies as a code of ethics, as required by SEC and NASDAQ Marketplace Rules. The Code of Conduct applies to all of QIAGEN’s employees, including our principal executive officer, principal financial officer, principal accounting officer or controller and other persons performing similar functions. The full text of the Code of Conduct is available on our website at www.qiagen.com.


Item 16C.	Principal Accountant Fees and Services

Audit Committee Pre-Approval Policies and Procedures

The Audit Committee has adopted a pre-approval policy that requires the pre-approval of all services performed for us by our independent registered public accounting firm. Additionally, the Audit Committee has delegated to the Committee Chairman full authority to approve any management request for pre-approval, provided the Chairman presents any approval given at its next scheduled meeting. All audit-related services, tax services and other services rendered by our independent registered public accounting firm or their affiliates were pre-approved by the Audit Committee and are compatible with maintaining the auditor’s independence.

At our 2012 Annual General Meeting of Shareholders held on June 27, 2012, our shareholders appointed Ernst & Young. Set forth below are the total fees billed (or expected to be billed), on a consolidated basis, by Ernst & Young and affiliates for providing audit and other professional services in each of the last two years:



(in thousands)	2012		2011
Audit fees	$	1,211	$	906
Audit-related fees	739		372
Tax fees	560		158
All other fees	1,398		233
Total	$	3,908	$	1,669

Audit fees consist of fees and expenses billed for the annual audit and quarterly review of QIAGEN’s consolidated financial statements. They also include fees billed for other audit services, which are those services that only the statutory auditor can provide, and include the review of documents filed with the Securities Exchange Commission.

Audit-related fees consist of fees and expenses billed for assurance and related services that are related to the performance of the audit or review of QIAGEN’s financial statements and include consultations concerning financial accounting and reporting standards and review of the opening balance sheets of newly acquired companies.

Tax fees include fees and expenses billed for tax compliance services, including assistance on the preparation of tax returns and claims for refund; tax consultations, such as assistance and representation in connection with tax audits and appeals, tax advice related to mergers and acquisitions, transfer pricing, and requests for rulings or technical advice from taxing authorities; tax planning services; and expatriate tax compliance, consultation and planning services.

All other fees include fees and expenses billed for services such as information technology projects, transaction due diligence and cost segregation studies as allowed by the Sarbanes-Oxley Act of 2002.


Item 16D.	Exemptions From the Listing Standards for Audit Committees

Not applicable.


Item 16E.

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Item 16E.	Purchases of Equity Securities by the Issuer and Affiliated Purchasers

The following table sets out information concerning repurchases of our common shares, which we intend to use to serve our exchangeable debt instruments and employee share-based remuneration plans. The approximate dollar value of shares that may yet be purchased under this program as of December 31, 2012 was $64.3 million.



Period	(a)Total Number of Shares Purchased	(b)Average Price Paid per Share (in $)	(c) Total Number of Shares Purchased as Part of Publicly Announced Plans and Programs	(d) Approximate Dollar Value of Shares that May Yet Be Purchased Under these Plans and Programs
October 10/1/2012 - 10/31/2012	544,242	$18.62	544,242	$89,864,000
November 1/1/2012 - 11/30/2012	619,459	$18.21	619,459	$78,586,000
December 12/1/2012 - 12/31/2012	779,090	$18.28	779,090	$64,347,000
Total	1,942,791	$18.35	1,942,791

Purchases between October 1, 2012 and December 31, 2012 were made in accordance with the authorization to acquire and use treasury shares granted at the Annual General Meeting of Shareholders on June 27, 2012, pursuant to which the Managing Board was authorized to acquire up to $100 million of QIAGEN common shares.


Item 16F.	Change in Registrant’s Certifying Accountant

Not applicable.


Item 16G.	Corporate Governance

Our corporate governance practices generally derive from the provisions of the Dutch Civil Code and the Dutch Corporate Governance Code. Further, due to our listing at the German Stock Exchange in Frankfurt, the Managing Board and the Supervisory Board of QIAGEN N.V. declared their intention to disclose in QIAGEN’s Annual Reports the Company’s compliance with the German Corporate Governance Code adopted by the Government Commission on the German Corporate Governance Code pursuant to §161 of the German Stock Corporation Law or state the deviations recorded in the period. These standards differ in some respects from the corporate governance practices followed by U.S. companies under the NASDAQ listing standards. A brief summary of the principal differences follows.

Two-Tier Board

QIAGEN is a ‘Naamloze Vennootschap,’ or N.V., a Dutch limited liability company similar to a corporation in the United States. QIAGEN has a two-tier board structure. QIAGEN is managed by a Managing Board consisting of executive management acting under the supervision of a Supervisory Board (non executives), similar to a Board of Directors in a U.S. corporation. The Managing Board manages QIAGEN and is responsible for defining and achieving QIAGEN’s aims, strategy, policies and results. The Managing Board is also responsible for complying with all relevant legislation and regulations as well as for managing the risks associated with the business activities and the financing of QIAGEN. It reports related developments to and discusses the internal risk management and control systems with the Supervisory Board. The Managing Board is accountable for the performance of its duties to the Supervisory Board and the General Meeting of Shareholders (General Meeting). The Managing Board consists of one or more members as determined by the Supervisory Board. The members of the Managing Board are appointed by the General Meeting upon the joint meeting of the Supervisory Board and the Managing Board having made a binding nomination for each vacancy. However, the General Meeting may at all times overrule the binding nature of such a nomination by a resolution adopted by at least a two-thirds majority of the votes cast, if such majority represents more than half the issued share capital. Managing Directors are appointed annually for the period beginning on the date following the General Meeting up to and including the date of the General Meeting held in the following year. The remuneration of management is determined in accordance with a remuneration policy which has been approved by QIAGEN’s shareholders at the General Meeting on June 14, 2005. The remuneration of the members of the Managing Board will, with due observance of the remuneration policy, be determined by the Supervisory Board based on a proposal by its Compensation Committee.

The Supervisory Board supervises the policies of the Managing Board, the general course of QIAGEN’s affairs and the business enterprises which it operates. The Supervisory Board assists the Managing Board by providing advice relating to the business activities of QIAGEN. In discharging its duties, the Supervisory Board takes into account the interests of QIAGEN, its

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enterprise and all parties involved in QIAGEN, including shareholders and other stakeholders.

Members of the Supervisory Board are appointed annually for the period beginning on the date following the General Meeting up to and including the date of the General Meeting held in the following year. Members of the Supervisory Board may be suspended and dismissed by the General Meeting by a resolution adopted by a two-thirds majority of the votes cast, if such majority represents more than half of the issued share capital, unless the proposal was made by the Managing Board and the Supervisory Board in which case a simple majority of votes cast is sufficient. Pursuant to our Articles, members of the Supervisory Board cannot be involved in the day-to-day management of our business. Our Supervisory Board has specified matters requiring its approval, including decisions and actions which would fundamentally change the company’s assets, financial position or results of operations. The Supervisory Board has appointed an Audit Committee, a Compensation Committee and a Selection and Appointment (Nomination) Committee from among its members and can appoint other committees as deemed beneficial. The Supervisory Board has approved charters pursuant to which each of the committees operates.

Independence

Unlike the NASDAQ listing standards which require a majority of the Supervisory Board members to be independent, the Dutch Corporate Governance Code recommends that all Supervisory Board members, with the exception of not more than one person, shall be independent within the meaning of its “best practice” provision. In some cases the Dutch independence requirement is more stringent, such as by requiring a longer “look back” period (five years) for former executive directors. In other cases, the NASDAQ rules are more stringent, such as a broader definition of disqualifying affiliations. Currently, a majority of our Supervisory Board are “independent” under both the NASDAQ and Dutch definitions.

Independent Auditors

In contrast to rules applicable to U.S. companies, which require that external auditors be appointed by the Audit Committee, Dutch law requires that external auditors be appointed by the General Meeting. In accordance with the requirements of Dutch law, the appointment and removal of our independent registered public accounting firm must be approved by the General Meeting. The Supervisory Board nominates a candidate for the appointment as external auditor, for which purpose both the Audit Committee and the Managing Board advise the Supervisory Board. The remuneration of the external auditor, and instructions to the external auditor to provide non-audit services, shall be approved by the Supervisory Board on the recommendation of the Audit Committee and after consultation with the Managing Board. At least once every four years, the Supervisory Board and the Audit Committee shall conduct a thorough assessment of the functioning of the external auditor. The main conclusions of this assessment shall be communicated to the General Meeting for the purposes of assessing the nomination for the appointment of the external auditor.

Exemptions

Exemptions from the NASDAQ corporate governance standards are available to foreign private issuers, such as QIAGEN when those standards are contrary to a law, rule or regulation of any public authority exercising jurisdiction over such issuer or contrary to generally accepted business practices in the issuer’s country of domicile. In connection with QIAGEN’s initial public offering, NASDAQ granted QIAGEN exemptions from certain corporate governance standards that are contrary to the laws, rules, regulations or generally accepted business practices of The Netherlands. These exemptions and the practices followed by QIAGEN are described below:

QIAGEN is exempt from NASDAQ’s quorum requirements applicable to meetings of ordinary shareholders. In keeping with the law of The Netherlands and generally accepted business practices in The Netherlands, QIAGEN’s Articles of Association provide that there are no quorum requirements generally applicable to meetings of the General Meeting.

QIAGEN is exempt from NASDAQ’s requirements regarding the solicitation of proxies and provision of proxy statements for meetings of the General Meeting. QIAGEN does furnish proxy statements and solicit proxies for meetings of shareholders. Dutch corporate law sets a mandatory (participation and voting) record date for Dutch listed companies fixed at the twenty-eighth day prior to the day of the shareholders’ meeting. Shareholders registered at such record date are entitled to attend and exercise their rights as shareholders at the General Meeting, regardless of a sale of shares after the record date.

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another company or issued at a price less than the greater of book or market value other than in a public offering. QIAGEN’s Articles of Association do not require approval of the General Meeting prior to the establishment of a stock plan. The Articles of Association also permit the General Meeting to grant the Supervisory Board general authority to issue shares without further approval of the General Meeting. QIAGEN’s General Meeting has granted the Supervisory Board general authority to issue up to a maximum of our authorized capital without further approval of the General Meeting. QIAGEN plans to seek approval of the General Meetings for stock plans and stock issuances only where required under the law of The Netherlands or under QIAGEN’s Articles of Association.

Further Information

For additional information regarding our Boards, including the Audit and other Committees of our Supervisory Board, please refer to the discussion in Item 6 above.


Item 16H.	Mine Safety Disclosure

Not applicable.

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PART III


~~Item 16A.~~	~~Controls and Procedures~~


~~Item 16B.~~	~~Code of Ethics~~


~~Item 16C.~~	~~Principal Accountant Fees and Services~~

~~Audit Committee Pre-Approval Policies and Procedures~~

At our 2011 Annual General Meeting of Shareholders held on June 30, 2011, our shareholders appointed Ernst & Young. Set forth below are the total fees billed (or expected to be billed), on a consolidated basis, by Ernst & Young and affiliates for providing audit and other professional services in each of the last two years:

(in thousands) 2011 2010
Audit fees $ 906
$ 947
Audit-related fees 372
813
Tax fees 158
82
All other fees 233
963
Total $ 1,669
$ 2,805


~~Item 16D.~~	~~Exemptions From the Listing Standards for Audit Committees~~

~~Not applicable.~~


~~Item 16E.~~	~~Purchases of Equity Securities by the Issuer and Affiliated Purchasers~~

~~Not applicable.~~

~~Table of Contents~~


~~Item 16F.~~	~~Change in Registrant’s Certifying Accountant~~

~~Not applicable.~~


~~Item 16G.~~	~~Corporate Governance~~

~~Two-Tier Board~~

~~Independence~~

~~Table of Contents~~

~~Independent Auditors~~

~~Exemptions~~

QIAGEN is exempt from NASDAQ’s requirements that shareholder approval be obtained prior to the establishment of, or material amendments to, stock option or purchase plans and other equity compensation arrangements pursuant to which options or stock may be acquired by directors, officers, employees or consultants. QIAGEN is also exempt from NASDAQ’s requirements that shareholder approval be obtained prior to certain issuances of stock resulting in a change of control, occurring in connection with acquisitions of stock or assets of another company or issued at a price less than the greater of book or market value other than in a public offering. QIAGEN’s Articles of Association do not require approval of the General Meeting prior to the establishment of a stock plan. The Articles of Association also permit the General Meeting to grant the Supervisory Board general authority to issue shares without further approval of the General Meeting. QIAGEN’s General Meeting has granted the Supervisory Board general authority to issue up to a maximum of our authorized capital without further approval of the General Meeting. QIAGEN plans to seek approval of the General Meetings for stock plans and stock issuances only where required under the law of The Netherlands or under QIAGEN’s Articles of Association.

~~Further Information~~

~~For additional information regarding our Boards, including the Audit and other Committees of our Supervisory Board, please refer to the discussion in Item 6 above.~~


~~Item 16H.~~	~~Mine Safety Disclosure~~

~~Not applicable.~~

~~Table of Contents~~

~~PART III~~


Item 17.	Financial Statements

See Item 18.


Item 18.	Financial Statements

See pages F-1 through F-39 included herein.


(A)	The following financial statements, together with the reports of Ernst & Young thereon, are filed as part of this annual report:



Report of Independent Registered Public Accounting Firm	F-1
Report of Independent Registered Public Accounting Firm	F-2
Consolidated Balance Sheets	F-3
Consolidated Statements of Income	F-5
Consolidated Statements of Comprehensive Income	F-6
Consolidated Statements of Changes Inin Equity	F-7
Consolidated Statements of Cash Flows	F-8
Notes to Consolidated Financial Statements	F-9
Schedule II—Valuation and Qualifying Accounts	S-1

~~Item 19. Exhibits~~


Item 19.	Exhibits



1.1	Articles of Association as confirmed by notorial deed as of June 30, 2011 (English translation) (Filed as Exhibit 4.1) (8)

2.3	Indenture between QIAGEN Finance (Luxembourg) S.A., QIAGEN N.V., Deutsche Trustee Company Limited, Deutsche Bank AG and Deutsche Bank Luxembourg S.A. dated August 18, 2004 (3)

2.4	Agreement In Connection With The Delivery Of Ordinary Shares In The Share Capital Of QIAGEN N.V. Pursuant To Convertible Notes Due 2024 Issued By QIAGEN Finance (Luxembourg) S.A. dated August 18, 2004 (3)

2.5	Amendment to Agreement In Connection With The Delivery Of Ordinary Shares In The Share Capital Of QIAGEN N.V. Pursuant To Convertible Notes Due 2024 Issued By QIAGEN Finance (Luxembourg) S.A. dated July 1, 2006 (5)

2.6	Indenture between QIAGEN Euro Finance (Luxembourg) S.A., QIAGEN N.V., Deutsche Trustee Company Limited, Deutsche Bank AG and Deutsche Bank Luxembourg S.A. dated May 16, 2006 (5)

2.7	Agreement In Connection With The Delivery Of Ordinary Shares In The Share Capital Of QIAGEN N.V. Pursuant To Convertible Notes Due 2026 Issued By QIAGEN Euro Finance (Luxembourg) S.A. dated May 8, 2006 (5)

2.8	Amendment to Agreement In Connection With The Delivery Of Ordinary Shares In The Share Capital Of QIAGEN N.V. Pursuant To Convertible Notes Due 2026 Issued By QIAGEN Euro Finance (Luxembourg) S.A. dated July 1, 2006 (5)

*2.9	$400 Million Note Purchase Agreement dated as of October 16, 2012

4.1	Lease Between QIAGEN GmbH and Gisantus Grundstuecksverwaltungsgesellschaft mbH, dated January 13, 1997 (the “Max-Volmer-Strasse 4 Lease”) (Filed as Exhibit 10.3) (1)

4.2	The “Max-Volmer-Strasse 4 Lease” Summary (Filed as Exhibit 10.3(a)) (1)

7377

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4.3	Lease, dated as of March 2, 1998, by and between Digene and ARE-Metropolitan Grove I, LLC (6)

4.4	Fourth Amendment to Lease, dated November 15, 2005, between ARE-Metropolitan Grove I, LLC and Digene Corporation (6)

4.5	QIAGEN N.V. Amended and Restated 2005 Stock Plan (Filed as Exhibit 99.1) (8)

4.6	Digene Corporation Amended and Restated Stock Option Plan (Filed as Exhibit 99.3) (2)

*8.1	List of Subsidiaries

*12.1	Certifications under Section 302; Peer M. Schatz, Managing Director and Chief Executive Officer

*12.2	Certifications under Section 302; Roland Sackers, Managing Director and Chief Financial Officer

*13.1	Certifications under Section 906; Peer M. Schatz, Managing Director and Chief Executive Officer and Roland Sackers, Managing Director and Chief Financial Officer

*15.1	Consent of Independent Registered Public Accounting Firm

†*101	XBRL Interactive Data File

____________________


*	Filed herewith.

†

Pursuant to Rule 406(T) of Regulation S-T, the Interactive Data Files on Exhibit 101 hereto are deemed not filed or part of a registration statement or prospectus for purposes of Sections 11 or 12 of the Securities Act of 1933 as amended, are deemed not filed for purposes of Section 18 of the Securities and Exchange Act of 1934, as amended, and otherwise are not subject to liability under those sections.


(1)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on March 31, 2000.


(2)	Incorporated by reference to Registration Statement of QIAGEN N.V. on Form S-8 filed with the Securities and Exchange Commission on August 7, 2007.


(3)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on April 19, 2005.


(4)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on April 3, 2006.


(5)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on April 2, 2007.


(6)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on March 20, 2008.


(7)	Incorporated by reference to Form 20-F Annual Report of QIAGEN N.V. filed with the Securities and Exchange Commission on March 17, 2010.


(8)	Incorporated by reference to Registration Statement of QIAGEN N.V. on Form S-8 filed with the Securities and Exchange Commission on November 17, 2011

7478

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SIGNATURES

The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this annual report on its behalf.



	QIAGEN N.V.
Dated: March ~~26, 2012~~1, 2013
	By:	/s/ Peer M. Schatz
		Peer M. Schatz, Chief Executive Officer

		/s/ Roland Sackers
		Roland Sackers, Chief Financial Officer

7579

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QIAGEN N.V. AND SUBSIDIARIES

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS



	Page
Report of Independent Registered Public Accounting Firm	F-1
Report of Independent Registered Public Accounting Firm	F-2
Consolidated Balance Sheets	F-3
Consolidated Statements of Income	F-5
Consolidated Statements of Comprehensive Income	F-6
Consolidated Statements of Changes in Equity	F-7
Consolidated Statements of Cash Flows	F-8
Notes to Consolidated Financial Statements	F-9

7680

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REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Supervisory Board and Shareholders of QIAGEN N.V. and Subsidiaries

We have audited the accompanying consolidated balance sheets of QIAGEN N.V. and Subsidiaries as of December 31, ~~2011~~2012 and ~~2010,~~2011, and the related consolidated statements of income, comprehensive income, changes in equity and cash flows for each of the three years in the period ended December 31, ~~2011.~~2012. Our audits also included the financial statement schedule listed in the Index at Item 18(A). These financial statements and schedule are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements and schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of QIAGEN N.V. and Subsidiaries at December 31, ~~2011~~2012 and ~~2010,~~2011, and the consolidated results of their operations and their cash flows for each of the three years in the period ended December 31, ~~2011,~~2012, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole, presents fairly in all material respects the information set forth therein.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), QIAGEN N.V. and Subsidiaries' internal control over financial reporting as of December 31, ~~2011,~~2012, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March ~~26, 2012~~1, 2013 expressed an unqualified opinion thereon.



March 1, 2013
				~~/s/~~
Ernst & Young GmbH
Wirtschaftsprüfungsgesellschaft
Düsseldorf, Germany
				~~Wirtschaftsprüfungsgesellschaft~~
~~March 26, 2012~~/s/ Hendrik Hollweg				/s/ Tobias Schlebusch
~~Mannheim, Germany~~Wirtschaftsprüfer				Wirtschaftsprüfer
[German Public Auditor]				[German Public Auditor]

F-1

Table of Contents

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Supervisory Board and Shareholders of QIAGEN N.V. and Subsidiaries

We have audited QIAGEN N.V. and Subsidiaries' internal control over financial reporting as of December 31, ~~2011,~~2012, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). QIAGEN N.V. and Subsidiaries' management is responsible for maintaining effective internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying Report of Management on Internal Control over Financial Reporting. Our responsibility is to express an opinion on the company's internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A company's internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company's internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company's assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, QIAGEN N.V. and Subsidiaries maintained, in all material respects, effective internal control over financial reporting as of December 31, ~~2011,~~2012, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of QIAGEN N.V. and Subsidiaries as of December 31, ~~2011~~2012 and ~~2010,~~2011, and the related consolidated statements of income, comprehensive income, changes in equity and cash flows for each of the three years in the period ended December 31, ~~2011~~2012 of QIAGEN N.V. and Subsidiaries and our report dated March ~~26, 2012~~1, 2013 expressed an unqualified opinion thereon.



March 1, 2013
				~~/s/~~
Ernst & Young GmbH
Wirtschaftsprüfungsgesellschaft
Düsseldorf, Germany
				~~Wirtschaftsprüfungsgesellschaft~~
~~March 26, 2012~~/s/ Hendrik Hollweg				/s/ Tobias Schlebusch
~~Mannheim, Germany~~Wirtschaftsprüfer				Wirtschaftsprüfer
[German Public Auditor]				[German Public Auditor]

F-2

Table of Contents

QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

(in $ thousands)


		As of December 31,					As of December 31,
	Note	2011		2010		Note	2012		2011
Assets
Current assets:
Cash and cash equivalents	(2)	$	221,133	$	828,407		$	394,037	$	221,133
Short-term investments	(9)	54,577		106,077		(7)	90,451		54,577
Accounts receivable, net of allowance for doubtful accounts of $4,315 and $3,227 in 2011 and 2010, respectively	(2)	230,770		197,418
Accounts receivable, net of allowance for doubtful accounts of $5,221 and $4,315 in 2012 and 2011, respectively						(3)	250,729		230,770
Income taxes receivable		19,009		10,920			39,150		19,009
Inventories, net	(2)	132,236		126,633		(3)	135,293		132,236
Prepaid expenses and other current assets	(10)	59,055		64,402		(8)	55,363		59,055
Deferred income taxes	(14)	31,652		30,731		(16)	27,598		28,609
Total current assets		748,432		1,364,588			992,621		745,389
Long-term assets:
Property, plant and equipment, net	(11)	371,792		345,664		(9)	418,932		371,792
Goodwill	(13)	1,733,722		1,352,281		(11)	1,759,898		1,733,722
Intangible assets, net of accumulated amortization of $417,430 and $312,326 in 2011 and 2010, respectively	(13)	819,487		753,327
Intangible assets, net of accumulated amortization of $532,006 and $417,430 in 2012 and 2011, respectively						(11)	853,872		819,487
Deferred income taxes	(14)	26,866		37,182		(16)	2,323		3,141
Other long-term assets		56,154		60,953			59,985		56,154
Total long-term assets		3,008,021		2,549,407			3,095,010		2,984,296
Total assets		$	3,756,453	$	3,913,995		$	4,087,631	$	3,729,685

The accompanying notes are an integral part of these consolidated financial statements.

F-3

Table of Contents

QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

(in $ thousands, except par value)


		As of December 31,						As of December 31,
	Note	2011			2010		Note	2012			2011
Liabilities and equity
Current liabilities:
Current portion of long-term debt	(16)	$	1,617		$	75,835	(15)	$	948		$	1,617
Short-term loans		142,329		—	—		(15)	—			142,329
Accounts payable		59,848			47,803			51,311			59,848
Accrued and other liabilities (of which $7,383 and $6,296 in 2011 and 2010 due to related parties)	(15), (20)	213,769			209,054
Accrued and other liabilities (of which $7,008 and $7,383 in 2012 and 2011 due to related parties)							(12) (23)	196,447			213,769
Income taxes payable		31,211			25,211			14,863			31,211
Deferred income taxes	(14)	32,883			30,504		(16)	3,300			2,862
Total current liabilities		481,657			388,407			266,869			451,636
Long-term liabilities:
Long-term debt, net of current portion (of which $445,000 in 2011 and 2010 due to related parties)	(16), (20)	446,005			797,171
Long-term debt, net of current portion (of which $445,000 in 2012 and 2011 due to related parties)							(15) (23)	846,044			446,005
Deferred income taxes	(14)	207,112			200,667		(16)	191,609			210,365
Other liabilities		63,881			51,397			58,746			63,881
Total long-term liabilities		716,998			1,049,235			1,096,399			720,251
Commitments and contingencies	(18)						(20)
Equity:
Preference shares, 0.01 EUR par value, authorized—450,000 shares, no shares issued and outstanding		—			—			—			—
Financing preference shares, 0.01 EUR par value, authorized—40,000 shares, no shares issued and outstanding		—			—			—			—
Common Shares, 0.01 EUR par value, authorized—410,000 shares, issued and outstanding—234,221 and 233,115 shares at December 31, 2011 and 2010, respectively		2,739			2,724
Common Shares, 0.01 EUR par value, authorized—410,000 shares, issued and outstanding— 236,487 and 234,221 shares at December 31, 2012 and 2011, respectively								2,769			2,739
Additional paid-in capital		1,673,733			1,648,985			1,718,163			1,673,733
Retained earnings		855,928			759,890			985,434			855,928
Accumulated other comprehensive income	(6)	15,904			64,754		(17)	43,991			15,904
Less treasury shares, at cost—1,943 shares at December 31, 2012							(18)	(35,653		)	—
Equity attributable to the owners of QIAGEN N.V.		2,548,304			2,476,353			2,714,704			2,548,304
Noncontrolling interest		9,494			—			9,659			9,494
Total equity		2,557,798			2,476,353			2,724,363			2,557,798
Total liabilities and equity		$	3,756,453		$	3,913,995		$	4,087,631		$	3,729,685

The accompanying notes are an integral part of these consolidated financial statements.

F-4

Table of Contents

QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF INCOME

(in $ thousands, except per share data)


		Years ended December 31,										Years ended December 31,
	Note	2011			2010			2009			Note	2012			2011			2010
Net sales	(2)	$	1,169,747		$	1,087,431		$	1,009,825		(3)	$	1,254,456		$	1,169,747		$	1,087,431
Cost of sales		419,938			371,869			342,752				430,432			419,938			371,869
Gross profit		749,809			715,562			667,073				824,024			749,809			715,562
Operating expenses:
Research and development	(2)	130,636			126,040			107,900			(3)	122,476			130,636			126,040
Sales and marketing		307,332			267,484			244,814				343,549			307,332			267,484
General and administrative, integration and other	(2)	185,507			110,009			115,933
General and administrative, restructuring, integration and other											(3) (6)	152,068			185,507			110,009
Acquisition-related intangible amortization		26,746			23,492			18,221				36,117			26,746			23,492
Total operating expenses		650,221			527,025			486,868				654,210			650,221			527,025
Income from operations		99,588			188,537			180,205				169,814			99,588			188,537
Other income (expense):
Interest income		6,128			4,457			3,522				2,382			6,128			4,457
Interest expense		(25,358		)	(27,815		)	(29,641		)		(23,452		)	(25,358		)	(27,815		)
Other income, net		15,854			7,942			18,244
Other (expense) income, net												(3,591		)	15,854			7,942
Total other expense		(3,376		)	(15,416		)	(7,875		)		(24,661		)	(3,376		)	(15,416		)
Income before provision for income taxes		96,212			173,121			172,330				145,153			96,212			173,121
Provision for income taxes	(2), (14)	1,263			28,810			34,563			(3) (16)	15,616			1,263			28,810
Net income		94,949			144,311			137,767				129,537			94,949			144,311
Net (loss) attributable to noncontrolling interest		(1,089		)	—			—
Net income (loss) attributable to noncontrolling interest												31			(1,089		)	—
Net income attributable to the owners of QIAGEN N.V.		$	96,038		$	144,311		$	137,767			$	129,506		$	96,038		$	144,311
Basic net income per common share attributable to the owners of QIAGEN N.V.		$	0.41		$	0.62		$	0.67			$	0.55		$	0.41		$	0.62
Diluted net income per common share attributable to the owners of QIAGEN N.V.		$	0.40		$	0.60		$	0.64			$	0.54		$	0.40		$	0.60

Weighted-average common shares outstanding (in thousands)
Basic	(3)	233,850			232,635			206,928			(19)	235,582			233,850			232,635
Diluted	(3)	239,064			240,483			213,612			(19)	240,746			239,064			240,483

The accompanying notes are an integral part of these consolidated financial statements.

F-5

Table of Contents

QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(in $ thousands)


		Years ended December 31,										Years ended December 31,
	Note	2011			2010			2009			Note	2012			2011			2010
Net income		$	94,949		$	144,311		$	137,767			$	129,537		$	94,949		$	144,311
Gains (losses) on cash flow hedges, before tax	(7)	5,417			14,636			(12,741		)
Gains on cash flow hedges, before tax											(13)	305			5,417			14,636
Reclassification adjustments on cash flow hedges, before tax	(7)	(3,961		)	(8,874		)	8,367			(13)	781			(3,961		)	(8,874		)
Cash flow hedges, before tax		1,456			5,762			(4,374		)		1,086			1,456			5,762
Gains (losses) on pensions, before tax		180			(184		)	300
(Losses) gains on pensions, before tax												(863		)	180			(184		)
Foreign currency translation adjustments, before tax		(51,383		)	10,920			42,001				27,639			(51,383		)	10,920
Other comprehensive (loss) income, before tax		(49,747		)	16,498			37,927
Income tax relating to components of other comprehensive (loss) income		(1,174		)	(1,890		)	(2,936		)
Total other comprehensive (loss) income, after tax		(50,921		)	14,608			34,991
Other comprehensive income (loss), before tax												27,862			(49,747		)	16,498
Income tax relating to components of other comprehensive income (loss)												416			(1,174		)	(1,890		)
Total other comprehensive income (loss), after tax												28,278			(50,921		)	14,608
Comprehensive income		44,028			158,919			172,758				157,815			44,028			158,919
Comprehensive loss attributable to noncontrolling interest		3,160			—			—
Comprehensive (income) loss attributable to noncontrolling interest												(222		)	3,160			—
Comprehensive income attributable to the owners of QIAGEN N.V.		$	47,188		$	158,919		$	172,758			$	157,593		$	47,188		$	158,919

The accompanying notes are an integral part of these consolidated financial statements.

F-6

Table of Contents

QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY

(in $ thousands)


																								Note	Common Shares			Additional Paid-In Capital			Retained Earnings		Accumulated Other Comprehensive Income (Loss)			Treasury Shares					Equity Attributable to the Owners of QIAGEN N.V.			Non-controlling interest			Total Equity
	Note		Common Shares			Additional Paid-In Capital				Retained Earnings		Accumulated Other Comprehensive Income (Loss)			Equity Attributable to the Owners of QIAGEN N.V.			Non-controlling interest			Total Equity				Shares	Amount										Shares		Amount
			Shares	Amount
BALANCE AT DECEMBER 31, 2008			197,839	$	2,212	$	958,665			$	477,812	$	15,155		$	1,453,844		$	—		$	1,453,844
Net income			—	—		—				137,767		—			137,767			—			137,767
Unrealized loss, net on hedging contracts			—	—		—				—		(9,005		)	(9,005		)	—			(9,005		)
Realized loss, net on hedging contracts			—	—		—				—		5,841			5,841			—			5,841
Unrealized gain, net on pension			—	—		—				—		210			210			—			210
Translation adjustment, net			—	—		—				—		37,945			37,945			—			37,945
Common stock issuance from public offering			31,625	462		623,109				—		—			623,571			—			623,571
Common stock issuances from conversion of warrants			—	—		1				—		—			1			—			1
Common stock issuances under employee stock plans			2,610	37		26,883				—		—			26,920			—			26,920
Tax benefit of employee stock plans			—	—		3,363				—		—			3,363			—			3,363
Share-based compensation			—	—		9,747				—		—			9,747			—			9,747
Proceeds from subscription receivables			—	—		965				—		—			965			—			965
BALANCE AT DECEMBER 31, 2009			232,074	$	2,711	$	1,622,733			$	615,579	$	50,146		$	2,291,169		$	—		$	2,291,169			232,074	$	2,711	$	1,622,733		$	615,579	$	50,146		—		$	—		$	2,291,169		$	—		$	2,291,169
Net income			—	—		—				144,311		—			144,311			—			144,311				—	—		—			144,311		—			—		—			144,311			—			144,311
Unrealized gain, net on hedging contracts			—	—		—				—		9,807			9,807			—			9,807				—	—		—			—		9,807			—		—			9,807			—			9,807
Realized gain, net on hedging contracts			—	—		—				—		(6,125		)	(6,125		)	—			(6,125		)		—	—		—			—		(6,125		)	—		—			(6,125		)	—			(6,125		)
Unrealized loss, net on pension			—	—		—				—		(129		)	(129		)	—			(129		)		—	—		—			—		(129		)	—		—			(129		)	—			(129		)
Translation adjustment, net			—	—		—				—		11,055			11,055			—			11,055				—	—		—			—		11,055			—		—			11,055			—			11,055
Common stock issuances under employee stock plans			1,041	13		11,228				—		—			11,241			—			11,241				1,041	13		11,228			—		—			—		—			11,241			—			11,241
Tax benefit of employee stock plans			—	—		445				—		—			445			—			445
Excess tax benefit of employee stock plans																									—	—		445			—		—			—		—			445			—			445
Share-based compensation			—	—		13,592				—		—			13,592			—			13,592				—	—		13,592			—		—			—		—			13,592			—			13,592
Proceeds from subscription receivables			—	—		987				—		—			987			—			987				—	—		987			—		—			—		—			987			—			987
BALANCE AT DECEMBER 31, 2010			233,115	$	2,724	$	1,648,985			$	759,890	$	64,754		$	2,476,353		$	—		$	2,476,353			233,115	$	2,724	$	1,648,985		$	759,890	$	64,754		—		$	—		$	2,476,353		$	—		$	2,476,353
Acquisition of Ipsogen S.A.			—	—		—			—	—		—			—			42,437			42,437				—	—		—			—		—			—		—			—			42,437			42,437
Acquisition of Ipsogen S.A. shares from noncontrolling interests			—	—		—				—		—			—			(29,783		)	(29,783		)
Net income (loss)			—	—		—				96,038		—			96,038			(1,089		)	94,949
Acquisition of Ipsogen S.A. shares from non-controlling interests																									—	—		—			—		—			—		—			—			(29,783		)	(29,783		)
Net income																									—	—		—			96,038		—			—		—			96,038			(1,089		)	94,949
Unrealized gain, net on hedging contracts	(6	)	—	—		—				—		3,707			3,707			—			3,707				—	—		—			—		3,707			—		—			3,707			—			3,707
Realized gain, net on hedging contracts	(6	)	—	—		—				—		(2,825		)	(2,825		)	—			(2,825		)		—	—		—			—		(2,825		)	—		—			(2,825		)	—			(2,825		)
Unrealized gain, net on pension	(6	)	—	—		—				—		126			126			—			126				—	—		—			—		126			—		—			126			—			126
Translation adjustment, net	(6	)	—	—		—				—		(49,858		)	(49,858		)	(2,071		)	(51,929		)		—	—		—			—		(49,858		)	—		—			(49,858		)	(2,071		)	(51,929		)
Common stock issuances under employee stock plans			1,106	15		8,763				—		—			8,778			—			8,778				1,106	15		8,763			—		—			—		—			8,778			—			8,778
Tax benefit of employee stock plans			—	—		(4,565		)		—		—			(4,565		)	—			(4,565		)
Excess tax benefit of employee stock plans																									—	—		(4,565		)	—		—			—		—			(4,565		)	—			(4,565		)
Share-based compensation	(17	)	—	—		19,539				—		—			19,539			—			19,539				—	—		19,539			—		—			—		—			19,539			—			19,539
Proceeds from subscription receivables			—	—		1,011				—		—			1,011			—			1,011				—	—		1,011			—		—			—		—			1,011			—			1,011
BALANCE AT DECEMBER 31, 2011			234,221	$	2,739	$	1,673,733			$	855,928	$	15,904		$	2,548,304		$	9,494		$	2,557,798			234,221	$	2,739	$	1,673,733		$	855,928	$	15,904		—		$	—		$	2,548,304		$	9,494		$	2,557,798
Acquisition of Ipsogen S.A. shares from non-controlling interests																									—	—		—			—		—			—		—			—			(57		)	(57		)
Net income																									—	—		—			129,506		—			—		—			129,506			31			129,537
Unrealized gain, net on hedging contracts																								(17)	—	—		—			—		209			—		—			209			—			209
Realized loss, net on hedging contracts																								(17)	—	—		—			—		553			—		—			553			—			553
Unrealized loss, net on pension																								(17)	—	—		—			—		(598		)	—		—			(598		)	—			(598		)
Translation adjustment, net																								(17)	—	—		—			—		27,923			—		—			27,923			191			28,114
Purchase of treasury shares																								(18)	—	—		—			—		—			(1,943	)	(35,653		)	(35,653		)	—			(35,653		)
Common stock issuances under employee stock plans																									2,266	30		16,549			—		—			—		—			16,579			—			16,579
Excess tax benefit of employee stock plans																									—	—		1,489			—		—			—		—			1,489			—			1,489
Share-based compensation																								(21)	—	—		25,356			—		—			—		—			25,356			—			25,356
Proceeds from subscription receivables																									—	—		1,036			—		—			—		—			1,036			—			1,036
BALANCE AT DECEMBER 31, 2012																									236,487	$	2,769	$	1,718,163		$	985,434	$	43,991		(1,943	)	$	(35,653	)	$	2,714,704		$	9,659		$	2,724,363

The accompanying notes are an integral part of these consolidated financial statements.

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QIAGEN N.V. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CASH FLOWS

(in $ thousands)


		Years ended December 31,										Years ended December 31,
	Note	2011			2010			2009			Note	2012			2011			2010
Cash flows from operating activities:
Net income		$	94,949		$	144,311		$	137,767			$	129,537		$	94,949		$	144,311
Adjustments to reconcile net income to net cash provided by operating activities, net of effects of businesses acquired:
Depreciation and amortization		70,456			57,511			48,575				197,892			167,377			142,779
Amortization of acquisition-related intangible assets		96,921			85,268			71,819
Non-cash acquisition and restructuring related costs		43,029			—			10,030
Share-based compensation:
Non-cash acquisition, impairment and restructuring related costs												16,909			43,029			—
Share-based compensation expense	(17)	19,539			13,592			9,747			(21)	25,356			19,539			13,592
Excess tax benefits from share-based compensation		(4,153		)	(1,976		)	(5,942		)		(1,489		)	(4,153		)	(1,976		)
Deferred income taxes	(14)	(31,861		)	(19,942		)	(10,609		)	(16)	(22,767		)	(31,861		)	(19,942		)
Gain on sale of investments		—			—			(11,501		)
Changes in fair value of contingent consideration											(14)	(11,463		)	253			—
Other		(1,184		)	(12,113		)	1,907				(5,227		)	(1,437		)	(12,113		)
Net changes in operating assets and liabilities:
Accounts receivable	(2)	(28,203		)	(6,884		)	(25,213		)	(3)	(14,289		)	(28,203		)	(6,884		)
Inventories	(2)	(15,945		)	2,348			(21,534		)	(3)	(20,376		)	(15,945		)	2,348
Prepaid expenses and other	(10)	(10,082		)	6,431			(9,364		)	(8)	3,456			(10,082		)	6,431
Other assets		(4,183		)	(2,965		)	(8,213		)		7			(4,183		)	(2,965		)
Accounts payable		7,261			3,482			(9,076		)		(9,945		)	7,261			3,482
Accrued and other liabilities	(15)	19,577			(26,983		)	23,859			(12)	(13,255		)	19,577			(26,983		)
Income taxes	(14)	(6,244		)	13,639			12,473			(16)	(35,328		)	(6,244		)	13,639
Other		(5,098		)	(4,967		)	2,270				5,862			(5,098		)	(4,967		)
Net cash provided by operating activities		244,779			250,752			216,995				244,880			244,779			250,752
Cash flows from investing activities:
Purchases of property, plant and equipment		(86,805		)	(79,666		)	(52,179		)		(101,996		)	(86,805		)	(79,666		)
Proceeds from sale of equipment		2,020			3,474			869				1,312			2,020			3,474
Purchases of intangible assets		(34,583		)	(44,243		)	(17,178		)		(26,089		)	(34,583		)	(44,243		)
Proceeds from sale/ cash paid for investments		(19,284		)	7,985			1,476
Proceeds from sale / cash paid for investments												(8,173		)	(19,284		)	7,985
Purchases of short-term investments	(9)	(186,817		)	(110,076		)	(40,000		)	(7)	(39,942		)	(186,817		)	(110,076		)
Sales of short-term investments	(9)	242,630			44,000			—			(7)	5,999			242,630			44,000
Cash paid for acquisitions, net of cash acquired	(4)	(457,483		)	(36,985		)	(234,732		)	(5)	(131,997		)	(457,483		)	(36,985		)
Net cash used in investing activities		(540,322		)	(215,511		)	(341,744		)		(300,886		)	(540,322		)	(215,511		)
Cash flows from financing activities:
Proceeds from short term debt	(16)	142,329			—			—
Net repayment/proceeds from short-term debt											(15)	(143,311		)	142,329			—
Proceeds from debt	(16)	44,000			3,016			—			(15)	400,000			44,000			3,016
Repayment of debt	(16)	(469,857		)	(50,000		)	(25,000		)	(15)	(1,607		)	(469,857		)	(50,000		)
Cash paid for debt issuance costs											(15)	(2,084		)	—			—
Principal payments on capital leases		(3,703		)	(3,262		)	(2,991		)		(3,780		)	(3,703		)	(3,262		)
Proceeds from subscription receivables		1,011			987			965				1,036			1,011			987
Excess tax benefits from share based compensation		4,153			1,976			5,942				1,489			4,153			1,976
Issuance of common shares		8,778			11,241			650,492
Proceeds from the exercise of stock options												16,579			8,778			11,241
Purchase of treasury shares											(18)	(35,653		)	—			—
Acquisition of noncontrolling interest		(29,783		)	—			—				(57		)	(29,783		)	—
Other financing activities		(7,558		)	814			(210		)		(6,008		)	(7,558		)	814
Net cash (used in) provided by financing activities		(310,630		)	(35,228		)	629,198
Net cash provided by (used in) financing activities												226,604			(310,630		)	(35,228		)
Effect of exchange rate changes on cash and cash equivalents		(1,101		)	2,837			(12,205		)		2,306			(1,101		)	2,837
Net (decrease) increase in cash and cash equivalents		(607,274		)	2,850			492,244
Net increase (decrease) in cash and cash equivalents												172,904			(607,274		)	2,850
Cash and cash equivalents, beginning of year		828,407			825,557			333,313				221,133			828,407			825,557
Cash and cash equivalents, end of year		$	221,133		$	828,407		$	825,557			$	394,037		$	221,133		$	828,407
Supplemental cash flow disclosures:
Cash paid for interest		$	20,760		$	25,557		$	27,662			$	17,298		$	20,760		$	25,557
Cash paid for income taxes		$	41,494		$	33,781		$	36,003			$	61,586		$	41,494		$	33,781
Supplemental disclosure of non-cash investing and financing activities:
Equipment purchased through capital lease		$	545		$	1,185		$	376			$	492		$	545		$	1,185
Investment acquired in non-monetary exchange												$	3,842		$	—		$	—
Intangible assets acquired in non-monetary exchange		$	—		$	30,341		$	—			$	5,658		$	—		$	30,341

The accompanying notes are an integral part of these consolidated financial statements.

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QIAGEN N.V. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

DECEMBER 31, ~~2011~~2012


1.	~~Description of the Business and Basis of Presentation~~

1. Corporate Information and Basis of Presentation

QIAGEN N.V. is a public limited liability company ('naamloze vennootschap') under Dutch law with registered office at Spoorstraat 50, Venlo, The Netherlands. QIAGEN N.V., a Netherlands holding company, and subsidiaries (we, our or the Company) is a leading provider of innovative ~~sample~~Sample and ~~assay technologies.~~Assay Technologies. These technologies—consumable products such as sample and assay kits and automated instrumentation systems—empower customers to transform raw biological samples into valuable molecular information. We serve four major customer classes: Molecular Diagnostics laboratories; Applied Testing customers in fields such as forensics, veterinary diagnostics and food safety; Pharmaceutical research and development groups, and Academic researchers. We market our products in more than 100 countries.

During 2011, we acquired all the shares of Cellestis Ltd. and a majority of the shares in Ipsogen S.A, as discussed more fully in Note 4. These acquisitions have been accounting for as business combinations, and the acquired companies' results have been included in the accompanying financial statements form their respective dates of acquisition.

~~Basis of Presentation~~

The accompanying consolidated financial statements were prepared in ~~conformity~~accordance with U.S. generally accepted accounting principles (GAAP) and all amounts are presented in U.S. dollars rounded to the nearest thousand, unless otherwise indicated.

~~Reclassifications~~

~~Certain reclassifications of prior year amounts~~ The consolidated financial statements have been ~~made to conform to~~prepared on a historical cost basis, except for derivative financial instruments, contingent consideration and available-for-sale financial instruments that have been measured at fair value.

On May 3, 2012, we acquired AmniSure International LLC, located in Boston, Massachusetts (AmniSure). Accordingly, as of May 3, 2012, all of the ~~current year presentation in Note 14 related to~~assets acquired and liabilities assumed were recorded at their respective fair values and our consolidated results of operations for the ~~prior year presentation of certain gross deferred tax asset information.~~periods ended December 31, 2012 include AmniSure’s operating results from May 3, 2012 through December 31, 2012.


2.	~~Summary of Significant Accounting Policies~~

2. Effects of New Accounting Pronouncements

Adoption of New Accounting Standards

In May 2011, the Financial Accounting Standards Board (FASB) issued ASU No. 2011-04, Amendments to Achieve Common Fair Value Measurement and Disclosure Requirements in U.S. GAAP and IFRS, to amend FASB ASC 820, Fair Value Measurement, to improve comparability of fair value measurements in both U.S. GAAP and IFRS financial statements. Under these amendments, the FASB does not intend to cause any change in the application of the requirements under Topic 820. Some amendments provide clarification on the application of existing fair value measurement requirements, while other amendments change a particular principle or requirement for measuring fair value, or change disclosure requirements about fair value measurements. This guidance became effective for us on January 1, 2012, and the adoption had no effect on our financial position, results of operations or cash flows.

In September 2011, the FASB issued ASU No. 2011- 08, Intangibles-Goodwill and Other (Topic 350) (ASU 2011-08), permitting entities the option to first assess qualitative factors to determine whether it is more likely than not that the fair value of a reporting unit is less than its carrying amount as a basis for determining whether it is necessary to perform the two-step goodwill impairment test. ASU No. 2011- 08 was effective for the Company January 1, 2012 and the adoption had no effect on our financial position, results of operations or cash flows.

In June 2011, the FASB issued ASU No. 2011-05, Comprehensive Income (Topic 220)-Presentation of Comprehensive Income, to increase the prominence of items reported in other comprehensive income and to facilitate convergence of U.S. GAAP and IFRS. This amendment requires that all nonowner changes in equity be presented either in a single continuous statement of comprehensive income or in two separate but consecutive statements. The amendment therefore eliminates the option to present components of other comprehensive income as part of the statement of changes in equity. This amendment does not change the items reported under other comprehensive income, it does not change when an item of other comprehensive income must be reclassified to net income and entities can choose to show line items net of tax effects or show one amount of aggregate income tax expense or benefit. This amendment must be applied retrospectively and for public entities, these amendments become effective for interim and fiscal periods beginning after December 15, 2011. We comply with the provisions of this amendment by using the two statement approach.

New Accounting Standards Not Yet Adopted

In December 2011, the FASB issued Accounting Standards Update No. 2011-11, “Balance Sheet (Topic 210): Disclosures about Offsetting Assets and Liabilities,” (ASU 2011-11). ASU 2011-11 enhances disclosures regarding financial instruments and derivative instruments. Entities are required to provide both net information and gross information for these

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assets and liabilities in order to enhance comparability between those entities that prepare their financial statements on the basis of U.S. GAAP and those entities that prepare their financial statements on the basis of IFRS. The requirements of ASU 2011-11 are to be applied retrospectively and are effective for us on January 1, 2013. We do not expect the adoption of these provisions to have a material impact on our consolidated financial statements.

In July 2012, the FASB issued ASU No. 2012-02, Intangibles-Goodwill and Other (Topic 350): Testing Indefinite-Lived Intangible Assets for Impairment (ASU 2012-02), allowing entities the option to first assess qualitative factors to determine whether it is necessary to perform the quantitative impairment test. If the qualitative assessment indicates it is more-likely-than-not that the fair value of an indefinite-lived intangible asset is less than its carrying amount, the quantitative impairment test is required. Otherwise, no testing is required. ASU 2012-02 is effective for us in the period beginning January 1, 2013 and the adoption is not expected to have an effect on our financial position, results of operations or cash flows.

In February 2013, the FASB issued Accounting Standards Update No. 2013-02, "Reporting of Amounts Reclassified Out of Accumulated Other Comprehensive Income" (ASU 2013-02). Under ASU 2013-02, an entity is required to provide information about the amounts reclassified out of AOCI by component. In addition, an entity is required to present, either on the face of the financial statements or in the notes, significant amounts reclassified out of AOCI by the respective line items of net income, but only if the amount reclassified is required to be reclassified in its entirety in the same reporting period. For amounts that are not required to be reclassified in their entirety to net income, an entity is required to cross-reference to other disclosures that provide additional details about those amounts. ASU 2013-02 does not change the current requirements for reporting net income or other comprehensive income in the financial statements. ASU 2013-02 is effective for us on January 1, 2013.

3. Summary of Significant Accounting Policies and Critical Accounting Estimates

Principles of Consolidation

The consolidated financial statements include the accounts of QIAGEN N.V. and its wholly-owned subsidiaries that are not considered variable interest entities. All significant intercompany accounts and transactions have been eliminated. Investments in companies where we exercise significant influence over the operations but do not have control, and where we are not the primary beneficiary, are accounted for using the equity method. All other investments are accounted for under the cost method. When there is a portion of equity in an acquired subsidiary not attributable, directly or indirectly, to the Company, we record the fair value of the noncontrolling interests at the acquisition date and classify the amounts attributable to noncontrolling interests separately in equity in the consolidated financial statements. Any subsequent changes in the Company's ownership interest while the Company retains its controlling financial interest in its subsidiary are accounted for as equity transactions.

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and disclosure of contingencies at the date of the financial statements as well as the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

Concentrations of Risk

We buy materials for products from many suppliers, and are not dependent on any one supplier or group of suppliers for the business as a whole. However, key components of certain products, including certain instrumentation components and chemicals, are available only from a single source. If supplies from these vendors were delayed or interrupted for any reason, we may not be able to obtain these materials timely or in sufficient quantities in order to produce certain products and sales levels could be negatively affected. Additionally, our customers include researchers at pharmaceutical and biotechnology companies, academic institutions, and government and private laboratories. Fluctuations in the research and development budgets of these researchers and their organizations for applications in which our products are used could have a significant effect on the demand for our products.

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The financial instruments used in managing our foreign currency and interest rate exposures have an element of risk in that the counterparties may be unable to meet the terms of the agreements. We attempt to minimize this risk by limiting the counterparties to a diverse group of highly-rated international financial institutions. The carrying values of our financial instruments incorporate the non-performance risk by using market pricing for credit risk. However, we have no reason to believe that any counterparties will default on their obligations and therefore do not expect to record any losses as a result of counterparty default. In order to minimize our exposure with any single counterparty, we have entered into master agreements which allow us to manage the exposure with the respective counterparty on a net basis. In connection with such agreements, we

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do not require and are not required to pledge collateral for derivative transactions.

Other financial instruments that potentially subject us to concentrations of credit risk are cash and cash equivalents, short-term investments, and accounts receivable. We attempt to minimize the risks related to cash and cash equivalents and short-term investments by dealing with highly-rated financial institutions and investing in a broad and diverse range of financial instruments. We have established guidelines related to credit quality and maturities of investments intended to maintain safety and liquidity. Concentration of credit risk with respect to accounts receivable is limited due to a large and diverse customer base, which is dispersed over different geographic areas. Allowances are maintained for potential credit losses and such losses have historically been within expected ranges.

Foreign Currency Translation

Our reporting currency is the U.S. dollar and our subsidiaries’ functional currencies are generally the local currency of the respective countries in which they are headquartered. All amounts in the financial statements of entities whose functional currency is not the U.S. dollar are translated into U.S. dollar equivalents at exchange rates as follows: (1) assets and liabilities at period-end rates, (2) income statement accounts at average exchange rates for the period, and (3) components of equity at historical rates. Translation gains or losses are recorded in equity, and transaction gains and losses are reflected in net income as a component of other income, net. Realized gains or losses on the value of derivative contracts entered into to hedge the exchange rate exposure of receivables and payables are also included in net income as a component of other income, net. The net gain (loss) on foreign currency transactions in ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010 was$(7.2) million, $12.4 million, ~~$2.6 million~~, and $~~5.6~~2.6 million, respectively, and is included in other (expense) income, net.

Segment Information

We determined that we operate as one operating segment in accordance with the Financial Accounting Standards Board (FASB) Accounting Standards Codification (ASC) Topic 280, Segment Reporting. Our chief operating decision maker (CODM) makes decisions based on the Company as a whole. In addition, we have a common basis of organization and types of products and services which derive revenues and consistent product margins. Accordingly, we operate and make decisions as one reporting unit. ~~Certain reclassifications of prior year amounts have been made to conform to the current year presentation, including reclassifications related to reporting as a single segment under ASC Topic 280,~~ ~~Segment Reporting~~.

Revenue Recognition

Our revenues are reported net of sales and value added taxes, discounts and sales allowances, and are derived primarily from the sale of consumable and instrumentation products, and to a much lesser extent, from the sale of services, intellectual property and technology. We recognize revenue when four basic criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the fee is fixed or determinable; and (4) collectability is reasonably assured.

Consumable and Related Products: Revenue from consumable product sales typically accounts for approximately 83-87% of our net sales and is generally recognized upon transfer of title consistent with the shipping terms. We maintain a small amount, on average less than $3.0 million in total, of consignment inventory at certain customer locations. Revenues for the consumable products which are consigned in this manner are recognized upon consumption. We generally allow returns of consumable products if the product is returned in a timely manner and in good condition. Allowances for returns are provided for based upon the historical pattern of returns and Management’s evaluation of specific factors that impact the risk of returns.

~~Related revenue includes~~Revenues from related products include license fees, intellectual property and patent sales, royalties and milestone ~~payments.~~payments and typically account for approximately 1-3% of our net sales. License fees from research collaborations include payments for technology transfer and access rights. Non-refundable, up-front payments received in connection with collaborative research and development agreements are generally deferred and recognized on a straight-line basis over the contract period during which there is any continuing obligation. Revenue from intellectual property and patent sales is recognized when earned, either at the time of sale, or over the performance period. Payments for milestones, generally based on the achievement of substantive and at-risk performance criteria, are recognized in full at such time as the specified milestone has been achieved according to the terms of the agreement. Royalties from licensees are based on reported sales of licensed products and revenues are calculated based on contract terms when reported sales are

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reliably measurable, fees are fixed or determinable and collectability is reasonably assured.

Instrumentation: Revenue from instrumentation includes the instrumentation equipment, installation, training and other instrumentation services, such as extended warranty services or product maintenance ~~contracts.~~contracts and typically account for approximately 10-15% of net sales. Revenue from instrumentation equipment is generally recognized when title passes to the customer, upon either shipment or written customer acceptance after satisfying any installation and training requirements. ~~For~~

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We offer our customers access to our instrumentation ~~equipment~~via reagent rental agreements which place instrumentation with customers without requiring them to purchase the equipment. Instead, we recover the cost of providing the instrumentation in the amount charged for Sample and Assay Technology consumable products. The instruments placed with customers under a reagent rental agreement are depreciated and charged to cost of sales that contain other obligations, such as providing consumables, advanced training, separately-priced extended warranty services or separately-priced extended maintenance contracts, revenue is first allocated to separately-priced extended warranty or maintenance contracts based on the stated contract price, then the remaining contract value is allocated to the remaining elements based on objective, verifiable evidence of the fair value of the individual components. The price charged when the element is sold separately generally determines its fair value. Revenues for extended warranty services or extended product maintenance contracts are deferred and recognized on a straight-line basis over the ~~contract period.~~estimated life of the instrument, typically 3 to 5 years. The costs to maintain these instruments in the field are charged to cost of sales as incurred. Revenue from these reagent rental agreements is generally recognized as the consumable products are shipped.

We have contracts with multiple elements which are accounted for under ASC 605-25, Revenue Recognition—Multiple-Element Arrangements. Multiple-element arrangements are assessed to determine whether there is more than one unit of accounting. In order for a deliverable to qualify as a separate unit of accounting, all of the following criteria must be met:

The delivered items have value to the client on a stand-alone basis;

The arrangement includes a general right of return relative to the delivered items, and

Delivery or performance of the undelivered items is considered probable and substantially in the control of the Company.

Arrangement consideration is allocated at the inception of the arrangement to all deliverables on the basis of their relative selling price. Effective as of January 1, 2011, when applying the relative selling price method, the selling price for each deliverable is determined using (a) vendor-specific objective evidence of selling price, if it exists; or otherwise (b) third-party evidence of selling price. If neither vendor-specific objective evidence nor third-party evidence of selling price exists for a deliverable, then the best estimated selling price for the deliverable is used. Prior to January 1, 2011, only the vendor-specific objective evidence of selling price was used. The arrangement consideration is allocated to the separate units of accounting based on each unit’s relative fair value. Revenue is then recognized using a proportional-performance method, such as recognizing revenue based on relative fair value of products or services delivered, or on a straight-line basis as appropriate. If these criteria are not met, deliverables included in an arrangement are accounted for as a single unit of accounting and revenue and costs are deferred until the period in which the final deliverable is provided.

Warranty

We provide warranties on our products against defects in materials and workmanship generally for a period of one year. A provision for estimated future warranty costs is recorded in cost of sales at the time product revenue is recognized. Product warranty obligations are included in accrued and other liabilities in the accompanying consolidated balance sheets. The changes in the carrying amount of warranty obligations are as follows:


(in thousands)	Total			Total
BALANCE AT DECEMBER 31, 2009	$	3,468
Provision charged to cost of sales	3,678
Usage	(3,258		)
Adjustments to previously provided warranties, net	(477		)
Currency translation	29
BALANCE AT DECEMBER 31, 2010	$	3,440		$	3,440
Provision charged to cost of sales	4,376			4,376
Usage	(3,649		)	(3,649		)
Adjustments to previously provided warranties, net	(198		)	(198		)
Currency translation	(59		)	(59		)
BALANCE AT DECEMBER 31, 2011	$	3,910		$	3,910
Provision charged to cost of sales				4,631
Usage				(4,099		)
Adjustments to previously provided warranties, net				(213		)
Currency translation				134
BALANCE AT DECEMBER 31, 2012				$	4,363

Research and Development

Research and product development costs are expensed as incurred. Research and development expenses consist primarily of salaries and related expenses, facility costs and amounts paid to contract research organizations, and laboratories for the provision of services and materials as well as costs for internal use or clinical trials.

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Government Grants

We recognize government grants when there is reasonable assurance that all conditions will be complied with and the grant will be received. Our government grants generally represent subsidies for specified activities and are therefore recognized when earned as a reduction of the expenses recorded for the activity that the grants are intended to compensate. Thus, when the

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grant relates to research and development expense, the grant is recognized over the same period that the related costs are incurred. Otherwise, amounts received under government grants are recorded as liabilities in the balance sheet. When the grant relates to an asset, the value of the grant is deducted from the carrying amount of the asset and recognized over the same period that the related asset is depreciated.

Shipping and Handling Income and Costs

Shipping and handling costs charged to customers are recorded as revenue in the period that the related product sale revenue is recorded. Associated costs of shipping and handling are included in sales and marketing expenses. For the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, shipping and handling costs totaled $~~24.0~~23.4 million, $~~19.9~~24.0 million and $~~17.5~~19.9 million, respectively.

Advertising Costs

The costs of advertising are expensed as incurred and are included as a component of sales and marketing expense. Advertising costs for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010 were $~~6.3~~6.6 million, $~~7.6~~6.3 million and $~~10.6~~7.6 million, respectively.

General and Administrative, Integration and Other

General and administrative expenses primarily represent the costs required to support administrative infrastructure. In addition, we incur indirect acquisition and business integration costs in connection with business combinations. These costs represent incremental costs that we believe would not have been incurred absent the business combinations. Major components of these costs include payroll and related costs for employees remaining with the Company on a transitional basis; public relations, advertising and media costs for re-branding of the combined organization; and, consulting and related fees incurred to integrate or restructure the acquired operations. Other costs include relocation and restructuring costs. These costs are expensed as incurred.

Income Taxes

We account for income taxes under the liability method. Under this method, total income tax expense is the amount of income taxes expected to be payable for the current year plus the change from the beginning of the year for deferred income tax assets and liabilities established for the expected further tax consequences resulting from differences in the financial reporting and tax basis of assets and liabilities. Deferred tax assets and/or liabilities are determined by multiplying the differences between the financial reporting and tax reporting bases for assets and liabilities by the enacted tax rates expected to be in effect when such differences are recovered or settled. The effect on deferred taxes of a change in tax rates is recognized in income in the period that includes the enactment date.

Tax benefits are initially recognized in the financial statements when it is more likely than not that the position will be sustained upon examination by the tax authorities. Such tax positions are initially and subsequently measured as the largest amount of tax benefit that is greater than 50% likely of being realized upon ultimate settlement with the tax authority using the cumulative probability method, assuming the tax authority has full knowledge of the position and all relevant facts. Our policy is to recognize interest accrued related to unrecognized tax benefits in interest expense and penalties within the income tax provision.

Derivative Instruments

We enter into derivative financial instrument contracts to minimize the variability of cash flows or income statement impact associated with the anticipated transactions being hedged or to hedge fluctuating interest rates. As changes in foreign currency or interest rate impact the value of anticipated transactions, the fair value of the forward or swap contracts also changes, offsetting foreign currency or interest rate fluctuations. Derivative instruments are recorded on the balance sheet at fair value. Changes in fair value of derivatives are recorded in current earnings or other comprehensive income, depending on whether a derivative is designated as part of a hedge transaction.

Share-Based Payments

Compensation cost for all share-based payments is recorded based on the grant date fair value.

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Stock Options: We utilize the Black-Scholes-Merton valuation model for estimating the fair value of our stock options granted. Option valuation models, including Black-Scholes-Merton, require the input of highly subjective assumptions, and changes in the assumptions used can materially affect the grant date fair value of an award. These assumptions include the risk-free rate of interest, expected dividend yield, expected volatility, expected life of the award and forfeiture rate.

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Risk-Free Interest Rate—This is the average U.S. Treasury rate (having a term that most closely resembles the expected life of the option) at the date the option was granted.

Dividend Yield—We have never declared or paid dividends on our common stock and do not anticipate declaring or paying any dividends in the foreseeable future.

Expected Volatility—Volatility is a measure of the amount by which a financial variable such as a share price has fluctuated (historical volatility) or is expected to fluctuate (expected volatility) during a period. We use a combination of the historical volatility of our stock price and the implied volatility of market-traded options of our stock to estimate the expected volatility assumption input to the Black-Scholes-Merton model. Our decision to use a combination of historical and implied volatility is based upon the availability of actively traded options of our stock and our assessment that such a combination is more representative of future expected stock price trends.

Expected Life of the Option—This is the period of time that the options granted are expected to remain outstanding. We estimated the expected life by considering the historical exercise behavior. We use an even exercise methodology, which assumes that all vested, outstanding options are exercised uniformly over the balance of their contractual life.

Forfeiture Rate—This is the estimated percentage of options granted that are expected to be forfeited or cancelled on an annual basis before becoming fully vested. We estimated the forfeiture rate based on historical forfeiture experience.

Restricted Stock Units and Performance Stock Units: Restricted stock units and performance stock units represent rights to receive Common Shares at a future date. The fair market value is determined based on the number of ~~restricted~~ stock units granted and the fair market value of our shares on the grant date. The fair market value at the time of the grant, less an estimate for pre-vesting forfeitures, is recognized in expense over the vesting period.

Cash and Cash Equivalents

Cash and cash equivalents consist of cash on deposit in banks and other cash invested temporarily in various instruments that are short-term and highly liquid, and having an original maturity of less than 90 days at the date of purchase.

Short-Term Investments

Short-term investments are classified as “available for sale” and stated at fair value in the accompanying balance sheet. Interest income is accrued when earned and changes in fair market values are reflected as unrealized gains and losses, calculated on the specific identification method, as a component of accumulated other comprehensive income. The amortization of premiums and accretion of discounts to maturity arising from acquisition is included in interest income. A decline in fair value that is judged to be other-than-temporary is accounted for as a realized loss and the write-down is included in the consolidated statements of income. Realized gains and losses, determined on a specific identification basis, on the sale of short-term investments are included in income.

Fair Value of Financial Instruments

The carrying value of cash and cash equivalents, notes receivable, accounts receivable, accounts payable and accrued liabilities approximate their fair values because of the short maturities of those instruments. The carrying value of our variable rate debt and capital leases approximates their fair values because of the short maturities and/or interest rates which are comparable to those available to us on similar terms. The carrying values of the Senior Notes totaling $400.0 million issued in October 2012 and further described in Note 15, approximates fair value as of December 31, 2012 as neither the Treasury rates or credit spreads have changed significantly since the issuance date. The fair values of the notes payable to QIAGEN Finance and Euro Finance, further discussed in Note ~~16,~~15, were estimated by using available over-the-counter market information on the convertible bonds which were issued by QIAGEN Finance and Euro Finance, the values of which correlate to the fair value of the loan arrangements we have with QIAGEN Finance and Euro Finance which include the notes payable, the guarantee and the warrant agreement (further discussed in Note ~~12)~~10).

Accounts Receivable

Our accounts receivable are unsecured and we are at risk to the extent such amounts become uncollectible. We continually monitor accounts receivable balances, and provide for an allowance for doubtful accounts at the time collection becomes questionable based on payment history or age of the receivable. Amounts determined to be uncollectible are written off against the reserve. For the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, write-offs of accounts receivable totaled $~~0.6~~0.2 million, $~~0.8~~0.6 million and $~~0.6~~0.8 million while provisions for doubtful accounts which were charged to expense totaled $~~2.1~~1.0 million, $~~1.4~~2.1 million and $~~1.7~~1.4 million, respectively. For all years presented, no single customer represented more than ten percent of accounts receivable or consolidated net sales.

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~~percent of accounts receivable or consolidated net sales.~~

Inventories

Inventories are stated at the lower of cost, determined on a first-in, first-out basis, or market and include material, capitalized labor and overhead costs. Inventories consisted of the following as of December 31, ~~2011~~2012 and ~~2010~~2011:


	As of December 31,				As of December 31,
(in thousands)	2011		2010		2012		2011
Raw materials	$	26,645	$	23,738	$	29,755	$	26,645
Work in process	33,757		33,043		34,231		33,757
Finished goods	71,834		69,852		71,307		71,834
Total inventories	$	132,236	$	126,633	$	135,293	$	132,236

Property, Plant and Equipment

Property, plant and equipment, including equipment acquired under capital lease obligations, are stated at cost. Capitalized internal-use software costs include only those direct costs associated with the actual development or acquisition of computer software for internal use, including costs associated with the design, coding, installation and testing of the system. Costs associated with preliminary development, such as the evaluation and selection of alternatives, as well as training, maintenance and support are expensed as incurred. Depreciation is computed using the straight-line method over the estimated useful lives of the assets ~~(one~~(one to 40 years). Amortization of leasehold improvements is computed on a straight-line basis over the lesser of the remaining life of the lease or the estimated useful life of the improvement asset. We have a policy of capitalizing expenditures that materially increase assets’ useful lives and charging ordinary maintenance and repairs to operations as incurred. When property or equipment is disposed of, the cost and related accumulated depreciation and amortization are removed from the accounts and any gain or loss is included in earnings.

Acquired Intangibles and Goodwill

Acquired intangibles with alternative future uses are carried at cost less accumulated amortization and consist of licenses to technology held by third parties and other acquired intangible assets. Amortization is computed over the estimated useful life of the underlying patents, which has historically ranged from one to twenty years. Purchased intangible assets acquired in business combinations, other than goodwill, are amortized over their estimated useful lives unless these lives are determined to be indefinite. Intangibles are assessed for recoverability considering the contract life and the period of time over which the intangible will contribute to future cash flow. The unamortized cost of intangible assets, where cash flows are independent and identifiable from other assets, is evaluated periodically and adjusted, if necessary, if events and circumstances indicate that a decline in value below the carrying amount has occurred. For the years ended December 31, 2012 and 2011, we recorded intangible asset impairments of $2.0 million and $40.3 million, respectively, in general and administrative, restructuring, integration and other expense. There were no impairments in 2010.

Amortization expense related to developed technology and patent and license rights which have been acquired in a business combination is included in cost of sales. Amortization of trademarks, customer base and non-compete agreements which have been acquired in a business combination is recorded in operating expense under the caption ‘acquisition-related intangible amortization.’ Amortization expenses of intangible assets not acquired in a business combination are recorded within either the cost of sales, research and development or sales and marketing line items based on the use of the asset.

The estimated fair values of acquired in-process research and development projects which have not reached technological feasibility at the date of acquisition are capitalized and subsequently tested for impairment through completion of the development process, at which point the capitalized amounts are amortized over their estimated useful life. If a project is abandoned rather than completed, all capitalized amounts are written-off immediately.

Goodwill represents the difference between the purchase price and the estimated fair value of the net assets acquired arising from business combinations. Goodwill is subject to impairment tests annually or earlier if indicators of potential impairment exist, using a fair-value-based approach. We have elected to perform our annual test for indications of impairment as of October 1^st of each year. Following the annual impairment tests for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, goodwill has not been impaired.

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Investments

We have investments in non-marketable securities issued by privately held companies. These investments are included in other long-term assets in the accompanying consolidated balance sheets and are accounted for using the equity or cost method of accounting.

Investments are evaluated at least quarterly, or sooner if impairment indicators are noted, to determine if declines in value are other-than-temporary. In making that determination, we consider all available evidence relating to the realizable value of a security. This evidence includes, but is not limited to, the following:

adverse financial conditions of a specific issuer, segment, industry, region or other variables;

the length of time and the extent to which the fair value has been less than cost; and

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the financial condition and near-term prospects of the issuer.

The fair values of any of our cost or equity method investments have declined below their carrying value whenever adverse events or changes in circumstances indicate that recorded values may not be recoverable. If any such decline is considered to be other than temporary (based on various factors, including historical financial results, product development activities and the overall health of the affiliate’s industry), then a write-down of the investment would be recorded in operating expense to its estimated fair value. For the year ended December 31, 2012, we recorded an impairment of a cost method investment of $3.4 million in general and administrative, restructuring, integration and other expense.

Impairment of Long-Lived Assets

We review our long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset or a group of assets may not be recoverable. We consider, amongst other indicators, a history of operating losses or a change in expected sales levels to be indicators of potential impairment. Assets are grouped and evaluated for impairment at the lowest level for which there are identifiable cash flows that are largely independent of the cash flows of other groups of assets. If an asset is determined to be impaired, the loss is measured as the amount by which the carrying amount of the asset exceeds fair value which is determined by applicable market prices, when available. When market prices are not available, we generally measure fair value by discounting projected future cash flows of the asset. Considerable judgment is necessary to estimate discounted future cash flows. Accordingly, actual results could differ from such estimates. During the years ended December 31, 2012 and 2011, in connection with our internal restructuring we recorded an asset impairment ~~charge~~charges of$13.6 million and $42.1 million, respectively, in general and administrative, restructuring, integration and other expenses in the accompanying consolidated statements of income related to the abandonment of certain projects. There were no material impairment losses recognized for long-lived assets during the ~~years~~year ended December 31, 2010 ~~and 2009.~~.

~~Recent Authoritative Pronouncements~~

~~Adoption of New Accounting Standards~~4. Segment Information

~~In September 2011,~~Considering the ~~FASB issued Accounting Standard Update (ASU) No. 2011-08,~~acquisitions made during ~~Testing Goodwill for Impairment~~2012 ~~(the revised standard)~~, we determined that we still operate as one business segment in accordance with ASC Topic 280, Segment Reporting. ~~The revised standard is intended to reduce the cost~~As a result of our continued restructuring and ~~complexity~~streamlining of the ~~annual goodwill impairment test by providing entities an option~~growing organization, our chief operating decision maker (CODM) makes decisions with regards to ~~perform~~business operations and resource allocation based on evaluations of QIAGEN as a ~~"qualitative" assessment~~whole. Accordingly, we operate as one business segment. Summarized product category and geographic information is shown in the tables below.

Product Category Information

Net sales for the product categories are attributed based on those revenues related to ~~determine whether further impairment testing is necessary. We did not use this option in 2011.~~sample and assay products and similarly related revenues, and revenues derived from instrumentation sales.

~~In June 2011,~~



(in thousands)	2012		2011		2010
Net Sales
Consumables and related revenues	$	1,085,596	$	1,011,863	$	937,714
Instrumentation	168,860		157,884		149,717
Total	$	1,254,456	$	1,169,747	$	1,087,431

Geographical Information

Net sales are attributed to countries based on the ~~FASB issued ASU No. 2011-05,~~ ~~Comprehensive Income (Topic 220)—Presentation of Comprehensive Income~~, to increase the prominence of items reported in other comprehensive income and to facilitate convergence of U.S. GAAP and IFRS. This amendment requires that all nonowner changes in equity be presented either in a single continuous statement of comprehensive income or in two separate but consecutive statements. The amendment therefore eliminates the option to present components of other comprehensive income as partlocation of the ~~statement of changes~~subsidiary generating the sale. QIAGEN operates manufacturing facilities in ~~equity. This amendment does not change~~Germany, Switzerland, China, the ~~items reported under~~United Kingdom, France and the United States that supply products to other ~~comprehensive income, it does not change when an item of~~countries. The sales from these manufacturing operations to other comprehensive income must be reclassified to net income and entities can choose to show line items net of tax effects or show one amount of aggregate income tax expense or benefit. This amendment must be applied retrospectively and for public entities, these amendments become effective for interim and fiscal periods beginning after December 15, 2011. We believe we currently comply with the provisions of this amendment by using the two statement approach.

~~In May 2011, the FASB issued ASU No. 2011-04,~~ ~~Amendments to Achieve Common Fair Value Measurement and Disclosure Requirements in U.S. GAAP and IFRS, to amend FASB ASC 820,~~ ~~Fair Value Measurement~~, to improve comparability of fair value measurements in both U.S. GAAP and IFRS financial statements. Under these amendments, the FASB does not intend to cause any change in the application of the requirements under Topic 820. Some amendments provide clarification on the application of existing fair value measurement requirements, while other amendments change a particular principle or requirement for measuring fair value, or change disclosure requirements about fair value measurements. The amendments are to be applied prospectively and are effective for public entities for interim and annual periods beginning after December 15, 2011. We do not believe the adoption of this guidance will have a material impact on our consolidated financial statements.

~~In December 2010, the FASB issued ASU No. 2010-29,~~ ~~Disclosure of Supplementary Pro Forma Information for Business Combinations—a consensus of the FASB Emerging Issues Task Force, to amend FASB ASC 805,~~ ~~Business Combinations~~, regarding how public entities disclose supplemental pro forma information for business combinations that occur during the year. Under the amended guidance, a public entity that presents comparative financial statements must disclose the revenue and earnings of the combined entity as though the business combination(s) that occurred during the current year had occurred as of the beginning of the prior annual reporting period. The guidance in ASU 2010-29 also amends ASC 805 to require public entities to provide a description of the nature and amount of any material, nonrecurring pro forma adjustments directly attributable to business combination(s) thatcountries are included in the ~~reported pro forma revenue and earnings. We adopted this update on January 1, 2011.~~Net Sales of

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~~In April 2010,~~ the ~~FASB issued ASU No. 2010-17,~~ ~~Revenue Recognition—Milestone Method (Topic 605): Milestone Method of Revenue Recognition. The ASU codifies the consensus reached in Emerging Issues Task Force Issue No. 08-9,~~ ~~“Milestone Method of Revenue Recognition.”~~ The amendments in this ASU provide guidance on defining a milestone and determining when it may be appropriate to apply the milestone method of revenue recognition for research or development transactions. Consideration that is contingent on achievement of a milestone in its entirety may be recognized as revenue in the periodcountries in which the ~~milestone~~manufacturing locations are based. The intersegment portions of such net sales are excluded to derive consolidated net sales. No single customer represents more than ten percent of consolidated net sales. Our official country of domicile is ~~achieved only if~~ the ~~milestone is judged to meet certain criteria to be considered substantive. Milestones should be considered substantive in their entirety~~Netherlands, which reported net sales of $23.7 million, $23.9 million and ~~may not be bifurcated. An arrangement may contain both substantive~~$21.5 million for the years ended 2012, 2011 and ~~nonsubstantive milestones,~~2010, respectively, and ~~each milestone should be evaluated individually to determine if it is substantive. The amendments~~these amounts are included in the ASU are effective on a prospective basis for milestones achieved in fiscal years, and interim periods within those years, beginning on or after June 15, 2010. Early adoption is permitted. We adopted these updates on January 1, 2011 without any impact.

~~In April 2010, the FASB issued ASU No. 2010-12,~~ ~~Income Taxes (Topic 740).~~ This ASU codifies an SEC Staff Announcement relating to accounting for the Health Care and Education Reconciliation Act of 2010 and the Patient Protection and Affordable Care Act. On March 30, 2010, the U.S. President signed the Health Care and Education Reconciliation Act of 2010, which is a reconciliation bill that amends the Patient Protection and Affordable Care Act that was signed by the President on March 23, 2010 (collectively, the “Acts”). Questions had arisen about the effect, if any, of the two different signing dates. The SEC has concluded that the two Acts, when taken together, represent the current health care reformsline item Europe as passed by U.S. Congress and signed by the U.S. President and therefore would not object to the view that the two Acts should be considered together for accounting purposes. As a result of the Acts, a 2.3% excise tax will be imposed on the sale, including leases, of any taxable medical devices by the manufacturer, producer or importer of such devices. A “taxable medical device” is any FDA regulated device intended for human use. The excise tax will apply to the sales of all taxable medical devices occurringshown in the U.S. after December 31, 2012. While we continue to evaluate the impact of the Acts, at the present time, we expect a net positive impact from the legislation due to the expected increase in net sales resulting from increased health coverage, which will be partially offset by the excise tax.table below.

~~In October 2009, the FASB issued new authoritative guidance regarding~~ ~~“Revenue Recognition—Multiple Deliverable Revenue Arrangements.”~~ This guidance provides amendments for separating consideration in multiple deliverable arrangements and removes the objective-and-reliable-evidence-of-fair-value criterion from the separation criteria used to determine whether an arrangement involving multiple deliverables contains more than one unit of accounting, replaces references to “fair value” with “selling price” to distinguish from the fair value measurements required under the “~~Fair Value Measurements and Disclosures”~~ guidance, provides a hierarchy that entities must use to estimate the selling price, eliminates the use of the residual method for allocation, and expands the ongoing disclosure requirements. We adopted this update on January 1, 2011 and will apply its requirements for all new contracts entered into or materially modified after January 1, 2011. The adoption of this guidance did not have any material impact on the consolidated financial statements.


3.	~~Net Income per Common Share Attributable to the Owners of QIAGEN N.V.~~

We present basic and diluted earnings per share. Basic earnings per share is calculated by dividing the net income attributable to the owners of QIAGEN N.V. by the weighted average number of common shares outstanding. Diluted earnings per share reflect the potential dilution that would occur if all “in the money” securities to issue common shares were exercised. The following schedule summarizes the information used to compute earnings per common share:

Years ended December 31,
(in thousands) 2011 2010 2009
Weighted average number of Common Shares used to compute basic net income per Common Share 233,850
232,635
206,928
Dilutive effect of stock options and restrictive stock units 2,876
2,843
2,717
Dilutive effect of outstanding warrant shares 2,338
5,005
3,967
Weighted average number of Common Shares used to compute diluted net income per Common Share 239,064
240,483
213,612
Outstanding stock options and restrictive stock units having no dilutive effect, not included in above calculation 3,995
2,152
2,627
Outstanding warrants having no dilutive effect, not included in above calculation 23,591
21,462
22,500



(in thousands)	2012		2011		2010
Net Sales
Americas:
United States	$	518,130	$	466,502	$	472,682
Other Americas	42,921		55,137		50,912
Total Americas	561,051		521,639		523,594
Europe	459,321		444,441		398,029
Asia Pacific & Rest of World	234,084		203,667		165,808
Total	$	1,254,456	$	1,169,747	$	1,087,431

Long-lived assets include property, plant and equipment. The Netherlands, which is included in the balances for Europe, reported long-lived assets of $0.4 million and $1.1 million as of December 31, 2012 and 2011, respectively.

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(in thousands)	2012		2011
Long-lived assets
Americas:
United States	$	131,689	$	98,717
Other Americas	2,196		2,579
Total Americas	133,885		101,296
Europe	272,227		259,220
Asia Pacific & Rest of World	12,820		11,276
Total	$	418,932	$	371,792

~~Table of Contents~~5. Acquisitions


4.	~~Acquisitions and Divestiture~~

Acquisitions have been accounted for as business combinations, and the acquired companies’ results have been included in the accompanying consolidated statements of income from their respective dates of acquisition. Our acquisitions have historically been made at prices above the fair value of the acquired net assets, resulting in goodwill, due to expectations of synergies of combining the businesses. These synergies include use of our existing infrastructure, such as sales force, shared service centers, distribution channels and customer relations, to expand sales of the acquired businesses’ products; use of the infrastructure of the acquired businesses to cost-effectively expand sales of our products; and elimination of duplicative facilities, functions and staffing.

2012 Acquisitions

On May 3, 2012, we acquired AmniSure, a privately owned company that markets the AmniSure^® assay for determining whether a pregnant woman is suffering rupture of fetal membranes (ROM), a condition in which fluid leaks from the amniotic sac prematurely. The acquisition of AmniSure did not have a material business impact to net sales, net income or earnings per share, and therefore no pro forma financial information has been provided herein.

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As of December 31, 2012, the final purchase price allocation is as follows:



(in thousands)	AmniSure acquisition
Purchase price:
Cash consideration	$	101,415
Fair value of contingent consideration	4,530
	$	105,945

Allocation:
Working capital	$	5,297
Fixed and other long-term assets	267
Developed technology, licenses and know-how	28,941
Customer relationships	25,520
Tradenames	2,692
In-process research and development	4,522
Goodwill	44,369
Deferred tax liability on fair value of identifiable intangible assets acquired	(5,202		)
Long-term liabilities assumed	(461		)
	$	105,945

The weighted-average amortization period for the intangible assets is 9.5 years. The goodwill acquired is not deductible for tax purposes.

We acquired AmniSure in the second quarter of 2012. Since the acquisition date, the results of AmniSure are included in the consolidated results through December 31, 2012 and were not material. The total fair value of the contingent consideration for AmniSure of approximately $4.5 million has been recorded as purchase price using a probability-weighted analysis of the future milestones using discount rates between 0.7% and 2.0%. Under the purchase agreement, we could be required to make additional contingent cash payments totaling $35.0 million through 2017.

During 2012, we completed other acquisitions, including Intelligent Bio-Systems, Inc., which were not significant, either individually or in the aggregate, to the overall consolidated financial statements. The total cash paid for these acquisitions, net of cash acquired, was $31.2 million of which an amount of $5.2 million was retained in an escrow account to cover any claims for breach of any representations, warranties or indemnities. Certain acquisitions included contingent consideration where we are required to assess the acquisition date fair value of the contingent consideration liabilities, which is recorded as part of the purchase consideration. This is discussed further in Note 14, "Fair Value Measurements," where we assess and adjust the fair value of the contingent consideration liabilities, if necessary, until the settlement or expiration of the contingency occurs. The total fair value of the contingent consideration for these other acquisitions of approximately $12.0 million has been recorded as purchase price. Under the purchase agreements, we could be required to make contingent cash payments totaling $12.5 million through 2016. The fair value of the contingent cash payments of was determined using a discount rate of 0.7% to 1.6% and a probability regarding the accomplishment of the milestones of 95.0% to 100.0%.

Acquisition-related costs are expensed when incurred and are included in general and administrative, restructuring, integration and other in the accompanying consolidated statements of income. Acquisition-related costs for 2012 acquisitions amounted to $4.5 million.

We made contingent purchase price payments totaling $7.1 million in 2012 for acquisitions completed prior to 2012. The contingent purchase price payments were contractually due upon achievement of certain performance criteria of the acquired business.

2011 Acquisitions

On August 29, 2011, we acquired all outstanding shares of Cellestis Ltd., a publicly listed Australian company, for $372.5 million in cash. Cellestis develops and provides in-vitro diagnostics and life science research products based on its proprietary QuantiFERON^® technology. The technology provides information on the activity of the cell-mediated functions of the immune system from whole blood samples. By tapping into the body’s memory system, this approach allows diseases to be

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detected much earlier than with other diagnostic methods, such as PCR. With QuantiFERON^®, we ~~are adding~~added a “pre-molecular” technology that allows us to look even deeper than with DNA-based molecular testing and thereby strive to feed and drive our DNA-based molecular franchise. QuantiFERON^® is a trademark of Cellestis, Ltd.

OnThe final purchase price allocation for Cellestis did not differ from the preliminary estimates other than the recognition of approximately ~~July 8, 2011~~$6.2 million of additional customer relationships, $0.3 million of additional developed technology, $3.9 million decrease of long-term deferred tax liability and an additional $1.6 million of other opening balance sheet adjustments. The corresponding impact for these adjustments was a decrease to goodwill of $12.0 million. These changes to arrive at the final purchase price allocation were not material to the consolidated financial statements. As of December 31, 2012, the ~~Board of Directors of~~final purchase price allocation for Cellestis is as follows:



(in thousands)	Cellestis acquisition
Purchase price:
Cash consideration paid	$	372,452
	$	372,452

Allocation:
Working capital	$	18,465
Fixed and other long-term assets	1,112
Developed technology, licenses and know-how	67,500
Customer relationships	48,800
Tradenames	12,000
Goodwill	258,886
Deferred tax liability on fair value of identifiable intangible assets acquired	(34,079		)
Liabilities assumed	(232		)
	$	372,452

The weighted-average amortization period for intangible assets is 10.0 years. The goodwill acquired is not deductible for tax purposes.

During 2011, we acquired a majority shareholding in Ipsogen S.A. ~~voted in favor of QIAGEN’s offer for EUR~~ ~~12.90~~ ~~per share and QIAGEN entered into binding agreements with a group of major shareholders of Ipsogen to purchase a majority of the Ipsogen shares. Ipsogen,~~, a publicly listed company founded in 1999 and based in Marseille, France, that is a global leader in molecular profiling and personalized healthcare diagnostics for a broad range of applications in the field of hematology. The acquisition of Ipsogen provides QIAGEN access to a broad range of assays covering 15 biomarkers used worldwide for the diagnosis, prognosis and monitoring of patients with various blood cancers. Many of these assays also are used as companion diagnostics in personalized healthcare to make and guide treatment decisions. Many of Ipsogen’s assays have CE-IVD Marking in Europe and have been developed for use on QIAGEN's Rotor-Gene Q real-time PCR system. This has the potential to enable the smooth and rapid transfer of these unique products onto QIAGEN's QIAsymphony RGQ, a novel integrated sample-to-result laboratory automation platform that includes the Rotor-Gene Q system.

On July 12, 2011, we paid ~~EUR~~ €40.9 million ($57.4 million) for the initial 62.6% of Ipsogen outstanding common shares. On the acquisition date, the fair value of the noncontrolling interest was $42.4 million and the fair value of all Ipsogen outstanding shares and other equity instruments was approximately ~~EUR~~ €70.2 million ($99.9 million). The fair value of the noncontrolling interest was based on reference to quoted market values of Ipsogen stock. The assignment of the total consideration including the fair value of the noncontrolling interest as of the date of the acquisition is shown below.

Since ~~QIAGEN held more than~~ ~~50%, a public tender offer for~~ the ~~remaining shares at the same price was submitted and approved by the Autorité Des Marchés Financiers. As of~~ ~~December 31, 2011~~,acquisition we have paid an additional total of $29.8 million and hold ~~89.3%~~89.4% of the Ipsogen shares on a fully diluted ~~basis.~~basis as of December 31, 2012.

The final purchase price allocation for Ipsogen did not differ from the preliminary estimates other than the recognition of approximately $9.0 million of additional long-term deferred tax assets related to net operating losses, $8.1 million of additional developed technology, $2.8 million of additional long-term deferred tax liability related to the developed technology and a net change of $0.3 million to other intangible assets. The corresponding impact for these adjustments was a decrease to goodwill of $14.6 million. These changes to arrive at the final purchase price allocation were not material overall to the consolidated financial statements. As of December 31, ~~2011~~2012, the ~~preliminary~~final purchase price ~~allocations are~~allocation is as follows:

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(in thousands) Cellestis acquisition Ipsogen acquisition Total
Purchase price:
Cash consideration paid $ 372,452
$ 57,436
$ 429,888
Fair value of remaining shares —
42,437
42,437
$ 372,452
$ 99,873
$ 472,325

Preliminary allocation:

Working capital $ 16,893
$ 15,246
$ 32,139
Fixed and other long-term assets 1,112
2,429
3,541
Developed technology, licenses and know-how 67,200
36,400
103,600
Customer relationships 42,600
10,600
53,200
Tradenames 12,000
1,500
13,500
Goodwill 270,860
52,095
322,955
Deferred tax liability on fair value of identifiable intangible assets acquired (37,981 ) (16,485 ) (54,466 )
Liabilities assumed (232 ) (1,912 ) (2,144 )
$ 372,452
$ 99,873
$ 472,325

The allocations of the purchase prices are preliminary and is based upon information that was available to management at the time the financial statements were prepared. Accordingly, the allocation may change. We have gathered no information that indicates the final purchase price allocations will differ materially from the preliminary estimates other than for the final determination of the intangible assets acquired and the resulting deferred taxes with the acquisition of Cellestis and Ipsogen. Acquisition-related costs are expensed when incurred and are included in general, administrative, integration and other in the accompanying consolidated statements of income.



(in thousands)	Ipsogen acquisition
Purchase price:
Cash consideration paid	$	57,436
Fair value of remaining shares	42,437
	$	99,873

Allocation:
Working capital	$	15,284
Deferred tax asset of acquired NOLs	8,997
Fixed and other long-term assets	2,429
Developed technology, licenses and know-how	44,500
Customer relationships	11,000
Tradenames	1,400
Goodwill	37,500
Deferred tax liability on fair value of identifiable intangible assets acquired	(19,325		)
Liabilities assumed	(1,912		)
	$	99,873

The weighted-average amortization ~~periods~~period for ~~the acquired~~ intangible assets ~~with definite lives of Cellestis and Ipsogen~~ is 10 ~~years for developed technology, customer relationships and trade names and 7 years for licenses.~~years. The goodwill acquired ~~in these acquisitions~~ is not deductible for tax purposes.

Since the acquisition ~~date,~~dates, the results of Cellestis and Ipsogen are included in ~~the~~our consolidated results through December 31, 2011. Net sales for the combined companies totaled $28.6 million and net loss attributable to the owners of QIAGEN N.V. was $1.7 million as of December 31, 2011. Acquisition-related costs for Cellestis and Ipsogen for the year-ended December 31, 2011 amounted to $5.8 million and $5.6 million, respectively.

Pro forma results

The following unaudited pro forma information assumes that the ~~above acquisitions~~Cellestis and Ipsogen occurred at the beginning of the periods presented. For the years ended December 31, 2011 and 2010, pro forma net sales would have been $1,213.5 million and $1,140.2 million, pro forma net income would have been $91.9 million and $139.2 million, and pro forma diluted net income per common share would have been $0.38 and $0.58, respectively. These unaudited pro forma results are intended for informational purposes only and are not necessarily indicative of the results of operations that would have occurred had the acquisitions been in effect at the beginning of the periods presented, or of future results of the combined operations.

Other 2011 Acquisitions

During 2011, we completed three acquisitions which individually were not significant to the overall consolidated financial statements. The cash paid for other 2011 acquisitions, net of cash acquired, was $47.9 million. of which an amount of $8.5 million was retained in an escrow account to cover any claims for breach of any representations, warranties or indemnities. Certain acquisitions included contingent consideration where we are required to assess the acquisition date fair value of the contingent consideration liabilities, which is recorded as part of the purchase consideration. This is discussed further in Note 8,14, "Fair Value Measurements," where we continuously assess and adjust the fair value of the contingent consideration liabilities, if necessary, until the settlement or expiration of the contingency occurs. The total fair value of the milestone payments of approximately $~~24.9~~6.9 million, determined as of the acquisition date, has been recognized as purchase price. The fair value of the milestone payments of approximately $~~23.5~~5.5 million was determined using a discount rate of ~~0.80%~~1.70% and a probability regarding the accomplishment of the milestones of 90% to 100%. The fair value of the milestone payments of approximately $1.4 million was determined using a discount rate of 3.25% with the assumption that only the first milestone will be met based on the assumptions of the business plan. Under the purchase agreements at the time of acquisition, we could be required to make additional contingent cash payments totaling $44.0 million through 2016~~, of which~~ ~~$24.9 million~~ ~~was accrued at~~ ~~December 31, 2011~~.

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2010 Acquisitions

In 2010, we completed two acquisitions which individually were not significant to the overall consolidated financial statements. We acquired 100% of the shares of ESE GmbH (subsequently renamed QIAGEN Lake Constance GmbH), a privately held developer and manufacturer of UV and fluorescence optical measurement devices. ESE is based in Stockach,

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Germany. ESE pioneered the development and manufacturing of optical measurement systems for medical and industrial applications. The systems utilize unique, high-performance and award-winning fluorescence detection technologies integrated into compact modules. We have demonstrated that ESE’s fluorescence detection systems can be used to measure signals generated by our existing testing technologies, including the HDA and tHDA isothermal assay systems. We also acquired the food market business of the Institute for Product Quality (ifp), a Berlin-based company which sells food, veterinary and environmental quality control assays. The transaction was an asset purchase of primarily patents, know-how, intellectual property rights and customer data related to the business. We have entered into license and contract manufacturing agreements with ifp under which ifp will perform the production for QIAGEN.

Aggregate consideration paid in 2010 for the acquisitions was $22.7 million and an amount of $2.9 million was retained in an escrow account to cover any claims for breach of any representations, warranties or indemnities. ~~During~~ ~~2011~~ ~~and~~ ~~2010~~, ~~$1.3 million~~ ~~and~~ ~~$1.6 million, respectively of the funds were released along with the preacquisition contingencies.~~ Furthermore, the purchase agreements for both acquisitions included aggregate milestone payments of up to $8.1 million. ~~As of~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~, ~~$2.6 million~~ ~~and~~ ~~$5.2 million, respectively, was accrued.~~

~~2009 Acquisitions~~

~~DxS Ltd. Acquisition~~

On ~~September 21, 2009, we acquired~~ ~~100%~~ of the outstanding shares of DxS Ltd. (DxS), a privately-held developer and manufacturer of companion diagnostic products headquartered in Manchester, United Kingdom. With this acquisition, we believe that we have taken a strong leadership position in personalized healthcare (PHC). The transaction was valued at ~~$94.5 million~~ ~~in cash, plus up to an additional~~ ~~$35.0 million~~ ~~in contingent consideration. The acquisition date fair value of the total consideration was~~ ~~$112.1 million, which consisted of~~ ~~$94.5 million~~ ~~in cash and~~ ~~$17.6 million~~ for the acquisition date fair value of the contingent consideration. A portion of the purchase consideration was deposited in an escrow account with a paying agent to cover any claims for breach of representations, warranties, covenants or indemnities or failure to satisfy certain conditions. As a result, as of ~~December 31, 2011~~, ~~$4.8 million~~ (~~$8.7 million~~ ~~as of~~ ~~December 31, 2010) is included in prepaid expenses and other in the accompanying consolidated balance sheets. Correspondingly, we have recorded preacquisition contingencies of~~ ~~$4.8 million~~ (~~$8.7 million~~ ~~as of~~ ~~December 31, 2010) which are included in accrued and other liabilities in the accompanying consolidated balance sheets.~~

~~The contingent consideration of up to~~ ~~$35.0 million~~ ~~relates to specific commercial and other milestones, which, if met, will be paid. The preliminary total fair value of milestones was approximately~~ ~~$17.6 million~~ ~~which, as of the acquisition date, has been recognized as purchase price. The fair value of the milestone payments was determined using a discount rate of~~ ~~3.25%~~ ~~and a probability regarding the accomplishment of the milestones of~~ 90 to ~~95%. Refer to Note 8 of the Consolidated Financial Statements, "Fair Value Measurements", for additional information on the fair market valuation of the contingent consideration. As of~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~, ~~$11.2 million~~ ~~and~~ ~~$14.3 million~~ ~~was accrued respectively, and~~ ~~$6.3 million~~ ~~and~~ ~~$4.1 million~~ ~~was paid, respectively.~~

~~SABiosciences Acquisition~~

On ~~December 14, 2009, we acquired~~ ~~100%~~ of the outstanding shares of SABiosciences Corporation, located in Frederick, Maryland (USA). SABiosciences holds a leading position in the design and commercialization of disease- and pathway-focused real-time PCR-based assay panels, which are widely utilized in biomedical research and in the development of future drugs and diagnostics. At closing, the purchase price was ~~$97.6 million~~ ~~in cash. As of~~ ~~December 31, 2010, we have~~ ~~$5.9 million~~ of the consideration in an escrow account with a paying agent to cover any claims for breach of representations, warranties, covenants or indemnities or failure to satisfy certain conditions. This amount is included in prepaid expenses and other in the accompanying Consolidated Balance Sheet. Correspondingly, we have preacquisition contingencies of ~~$5.9 million~~ ~~which are included in accrued and other liabilities in the accompanying Consolidated Balance Sheet. As of~~ ~~December 31, 2011, the full amount of the escrow has been released along with the preacquisition contingencies.~~

~~As of~~ ~~December 31, 2010, the final allocation of the purchase price and transaction costs for the acquisitions of DxS and SABiosciences are follows:~~

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(in thousands)
DxS
Acquisition

SABiosciences
Acquisition
Total
Purchase Price:
Cash consideration paid $ 94,823
$ 97,586
$ 192,409
Fair value of milestones 17,599
—
17,599
$ 112,422
$ 97,586
$ 210,008
Final Allocation:

Working capital $ 263
$ 10,503
$ 10,766
Fixed and other long-term assets 2,199
2,215
4,414
Product technology and know how 16,400
26,400
42,800
Purchased in-process research and development 1,400
1,700
3,100
Customer relationships 54,900
8,400
63,300
Tradename 4,100
1,900
6,000
Goodwill 55,417
62,433
117,850
Deferred tax liability on fair value of identifiable intangible assets acquired (21,522 ) (15,965 ) (37,487 )
Liabilities assumed (735 ) —
(735 )
$ 112,422
$ 97,586
$ 210,008

~~The weighted-average amortization period for the intangible assets acquired with DxS is~~ 15 ~~years and with SABiosciences is~~ 10 ~~years. The goodwill acquired in these acquisitions is not deductible for tax purposes.~~

~~Other 2009 Acquisitions~~

On ~~August 6, 2009, we acquired Explera s.r.l., a leading supplier in molecular diagnostics and personalized medicine in Italy. The transaction is valued at~~ ~~$7.5 million~~ ~~with a fixed purchase price of~~ ~~$5.0 million~~ ~~and milestone payments of~~ ~~$2.5 million~~. With this acquisition, we expanded the size of our Molecular Diagnostics sales channel in Italy and added several activities in the area of personalized medicine and access to a suite of CE-IVD pyrosequencing assays.

On ~~November 12, 2009, we acquired~~ ~~100%~~ of the outstanding shares of a developer, producer and distributor of PCR-based technologies for forensics, kinship and paternity analysis, and other human identity testing applications located in Germany. Upon closing of the transaction, an upfront payment of ~~$23.3 million~~ ~~was paid to the sellers, less an amount of~~ ~~$13.1 million~~ which was originally retained in an escrow account to cover any claims for breach of any of representations, warranties or indemnities. The escrow funds were partially released to the sellers and another ~~$1.6 million~~ ~~was paid to the sellers during~~ ~~2010. There were no further claims against the escrow as of~~ ~~December 31, 2011~~.

~~2009 Divestiture~~

In ~~July 2009, through the sale of our subsidiary in Austria, we sold the Olerup SSP~~^® ~~product line and related assets to Olerup International AB, a subsidiary of LinkMed, a Swedish venture capital company specializing in life sciences. The Olerup SSP~~^® ~~product line includes molecular transplantation testing products used for DNA human leukocyte antigen (HLA) typing. We retained rights to all Olerup SSP~~^® assays for applications outside transplantation testing, such as in personalized medicine. The transaction does not affect our presence in new sequencing-based typing assays in the area of transplantation. We recorded a net gain of approximately ~~$1.2 million~~ ~~on the sale of the business, which is recorded in other income, net in~~ ~~2009~~.


5.	~~Restructuring~~

6. Restructuring

Late in 2011, we began a project to enhance productivity by streamlining the organization and freeing up resources for reallocation to strategic initiatives to help drive growth and innovation, strengthen our industry leadership position and improve longer-term profitability. This project aims to eliminate organizational layers and overlapping structures, actions that we expect will enhance our processes, speed and productivity. WeIn 2012, we recorded pretax charges of $41.0 million, recorded in general, administrative, restructuring and other. In 2011, we recorded pretax charges of $74.9 million ~~in the fourth quarter of~~ ~~2011~~, of which $5.5 million is recorded in cost of sales and $69.4 million is recorded in general and administrative, ~~integration~~restructuring and other. The pretax charges ~~consists~~in 2012 and 2011 consisted of$5.5 million and $20.1 million, respectively, for workforce reductions, $11.6 millionand $~~42.1~~1.8 million, respectively, for fixed asset impairments, and $2.0 million and $40.3 million, respectively, for intangible asset abandonment charges. The intangible asset charges represent the write off of capitalized costs related to development projects which were abandoned following the decision to streamline the organization and focus development efforts on those projects with the highest potential for market acceptance and profitability. Additionally, we incurred contract termination and consulting costs of $18.8 million and $12.7 million~~. At~~ for the years ended December 31, 2012 and 2011, a

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~~restructuring accrual of~~respectively, and in 2012 we recorded $~~26.9~~3.1 million ~~was included in accrued and other liabilities in the accompanying consolidated balance sheet.~~for lease closure costs. We expect to record additional restructuring charges in ~~2012~~2013 related to this program.

The specific restructuring measures and associated estimated costs were based on management's best business judgment under the existing circumstances at the time the estimates were made. If future events require changes to these estimates, such adjustments will be reflected in the applicable line item in the consolidated statement of operations.

~~2009 Restructuring~~

The following table summarizes the cash components of ~~Acquired Business~~the restructuring costs. At December 31, 2012 and 2011, restructuring accruals of $4.9 million and $26.9 million, respectively, were included in accrued and other liabilities in the accompanying consolidated balance sheets.



(in thousands)	Personnel Related			Facility Related			Contract and Other Costs			Total
Balance at December 31, 2011	$	19,228		$	443		$	7,238		$	26,909
Additional costs in 2012	5,456			3,055			152			8,663
Payments	(21,301		)	(1,032		)	(6,036		)	(28,369		)
Release of excess accrual	(1,084		)	—			(1,217		)	(2,301		)
Foreign currency translation adjustment	22			—			—			22
Balance at December 31, 2012	$	2,321		$	2,466		$	137		$	4,924

The costs in the above table do not include consulting costs associated with third-party service providers that are assisting with executing the restructuring. We accrue for consulting costs as the services are provided.

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7. Short-term Investments

InAt ~~October 2009~~December 31, 2012 and 2011, we ~~started~~had €62.5 million ($82.5 million as of December 31, 2012) and €35.0 million ($45.3 million as of December 31, 2011), respectively, of loan note receivables due from financial institutions. These loan receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market and are carried at fair market value, which is equal to the ~~closure~~cost. These loans consist of €47.5 million which mature in 2013 and €15.0 million in 2014. All of these instruments include put option rights on at least a quarterly basis. Interest income is determined using the effective interest rate method. These loans are classified as current assets in the accompanying consolidated balance sheets since we may put the loans at our ~~facilities and relocation of our activities in Brisbane and Sydney to other locations, primarily to QIAGEN Instruments AG in Switzerland. These restructurings follow the acquisition of Corbett in~~discretion.

At ~~2008~~December 31, 2012 and ~~consolidate our instrument manufacturing activities.~~2011, we also had €6.1 million ($8.0 million) and €7.2 million ($9.3 million), respectively in term deposits with final maturities until December 2014. The ~~closure~~deposits can be withdrawn at the end of each quarter without penalty and ~~relocation were completed~~are therefore classified as current assets in the accompanying consolidated balance sheets.

For the year ended ~~2010~~December 31, 2012 ~~at a total pre tax cost~~and 2011, proceeds from sales of ~~approximately~~short term investments totaled $~~4.2~~6.0 million and $242.6 million, ~~of which~~respectively. There were no realized gains or losses during ~~$1.9 million~~2012 ~~was incurred in~~or ~~2010~~2011.


6.	~~Accumulated Other Comprehensive Income~~

8. Prepaid Expenses and Other Current Assets

~~The following table is a summary~~Prepaid expenses and other current assets are summarized as follows as of ~~the components of accumulated other comprehensive income at~~ December ~~31:~~31, 2012 and 2011:

(in thousands) 2011 2010
Net unrealized loss on cash flow hedging contracts, net of tax of $0.1 million and $0.7 million in 2011 and 2010, respectively $ (762 ) $ (1,644 )
Net unrealized gain (loss) on pension, net of tax 115
(11 )
Foreign currency translation effects from intercompany long-term investment transactions, net of tax of $4.9 million and $4.4 million in 2011 and 2010, respectively 7,369
5,774
Foreign currency translation adjustments 9,182
60,635
Accumulated other comprehensive income $ 15,904
$ 64,754



(in thousands)	2012		2011
Prepaid expenses	$	30,354	$	27,832
Amounts held in escrow in connection with acquisitions	7,521		7,026
Value added tax	10,221		9,488
Other receivables	7,267		14,709
	$	55,363	$	59,055

9. Property, Plant and Equipment

Property, plant and equipment, including equipment acquired under capital lease obligations, are summarized as follows as of December 31, 2012 and 2011:



(in thousands)	Estimated useful life (in years)	2012			2011
Land	—	$	15,907		$	15,686
Buildings and improvements	2-40	283,173			275,529
Machinery and equipment	3-20	206,871			176,662
Computer software	1-10	86,280			65,344
Furniture and office equipment	1-13	80,343			76,809
Construction in progress	—	79,402			51,827
		751,976			661,857
Less: Accumulated depreciation and amortization		(333,044		)	(290,065		)
Property, plant and equipment, net		$	418,932		$	371,792

Amortization of assets acquired under capital lease obligations is included within accumulated depreciation and amortization above for the years ended December 31, 2012 and 2011, respectively. For the years ended December 31, 2012, 2011 and 2010 depreciation and amortization expense totaled $64.8 million, $57.0 million and $47.9 million, respectively. For the years ended December 31, 2012, 2011 and 2010 amortization expense related to computer software costs totaled the $8.2 million, $7.5 million and $4.6 million, respectively.

Repairs and maintenance expense was $13.7 million, $12.9 million and $11.8 million in 2012, 2011 and 2010, respectively. For the year ended December 31, 2012 and 2011, construction in progress includes amounts related to ongoing software development projects and the construction of new facilities in the United States. For the years ended December 31, 2012, 2011 and 2010, interest capitalized in connection with construction projects was not significant.

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7.	~~Derivatives and Hedging~~

10. Investments

We have made strategic investments in certain companies that are accounted for using the equity or cost method of accounting. The method of accounting for an investment depends on the level of influence. We monitor changes in circumstances that may require a reassessment of the level of influence. We periodically review the carrying value of these investments for impairment, considering factors such as the most recent stock transactions and book values from the recent financial statements. The fair value of cost and equity-method investments is estimated when there are identified events or changes in circumstances that may have an impact on the fair value of the investment. A summary of these equity method investments, which are included in other assets, is as follows:



			Equity investments as of December 31,				Share of income (loss) for the years ended December 31,
Company (in thousands)	Ownership Percentage		2012		2011		2012			2011			2010
PreAnalytiX GmbH	50.00	%	$	18,182	$	15,723	$	1,972		$	390		$	2,969
QBM Cell Science	19.50	%	$	406	$	395	$	11		$	(10	)	$	11
QIAGEN Finance	100.00	%	$	374	$	252	$	122		$	103		$	131
QIAGEN Euro Finance	100.00	%	$	931	$	622	$	309		$	266		$	273
Pyrobett	19.00	%	$	3,515	$	3,749	$	(234	)	$	(178	)	$	(73	)
Dx Assays Pte Ltd	33.30	%	$	—	$	—	$	—		$	—		$	—
Scandinavian Gene Synthesis AB	40.00	%	$	—	$	15,714	$	(23	)	$	23		$	—
Peak-Service	40.00	%	$	20	$	20	$	—		$	—		$	—

We have a 50% interest in a joint venture company, PreAnalytiX GmbH, for which each of the joint venture partners participates 50/50 in all decision making activities and therefore we are not the primary beneficiary. Thus, the investment is accounted for under the equity method. PreAnalytiX was formed to develop, manufacture and market integrated systems for the collection, stabilization and purification of nucleic acids for molecular diagnostic testing. At present, our maximum exposure to loss as a result of our involvement with PreAnalytiX is limited to our share of losses from the equity method investment itself.

We have a 100% interest in QIAGEN Finance (Luxembourg) S.A. (QIAGEN Finance) and QIAGEN Euro Finance (Luxembourg) S.A. (Euro Finance), companies established for the purpose of issuing convertible debt in 2004 and 2006, respectively. In August 2004, we issued $150.0 million of 1.5% Senior Convertible Notes (2004 Notes) due in 2024 through QIAGEN Finance. In May 2006, we completed the offering of $300.0 million of 3.25% Senior Convertible Notes (2006 Notes) due in 2026 through Euro Finance. The proceeds of the 2004 and 2006 Notes were loaned to subsidiaries within the consolidated QIAGEN N.V. group. QIAGEN N.V. has guaranteed all of these Notes, and has agreements with each of QIAGEN Finance and Euro Finance to issue common shares to the investors in the event of conversion of any of the Notes. QIAGEN Finance and Euro Finance are variable interest entities. We do not hold any variable interests in QIAGEN Finance or Euro Finance, and we are not the primary beneficiary, therefore neither of the entities is consolidated. Accordingly, the 2004 and 2006 convertible debt is not included in the consolidated statements of QIAGEN N.V., though QIAGEN N.V. does report the full obligation of the debt through its liabilities to QIAGEN Finance and Euro Finance. QIAGEN N.V. accounts for its investments in QIAGEN Finance and Euro Finance as equity investments and accordingly records 100% of the profit or loss of QIAGEN Finance and Euro Finance in the gain or loss from equity method investees. At present, our maximum exposure to loss as a result of our involvement with QIAGEN Finance and Euro Finance is limited to our share of losses from the equity method investments.

At December 31, 2012 and 2011, we had a total of cost-method investments in non-publicly traded companies with carrying amounts of $15.5 million and $6.8 million, respectively, which are included in other assets. The fair-value of these cost-method investments are not estimated unless there are identified events or changes in circumstances that may have a significant adverse effect on the fair value of the investment. For the year ended December 31, 2012, we recorded an impairment of a cost method investment of $3.4 million in general and administrative, restructuring, integration and other expense.

During 2011, we paid $9.7 million for a 40% share together with a $6.7 million advance payment towards the potential future acquisition of the remaining 60% of Scandinavian Gene Synthesis AB. In 2012, we acquired the remaining shares for $8.4 million.

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In 2010, we made a $4.0 million investment in Pyrobett, a company located in Singapore which performs research and development activities related to the development of instruments for use in life sciences.

11. Goodwill and Intangible Assets

The following sets forth the intangible assets by major asset class as of December 31, 2012 and 2011:



		2012					2011
(in thousands)	Weighted Average Life	Gross Carrying Amount		Accumulated Amortization			Gross Carrying Amount		Accumulated Amortization
Amortized Intangible Assets:
Patent and license rights	11.7	$	304,380	$	(134,688	)	$	294,854	$	(115,310	)
Developed technology	10.0	678,888		(270,575		)	605,847		(210,022		)
Customer base, trademarks, and non-compete agreements	10.3	391,388		(126,743		)	336,216		(92,098		)
	10.4	$	1,374,656	$	(532,006	)	$	1,236,917	$	(417,430	)
Unamortized Intangible Assets:
In-process research and development		$	11,222				$	—
Goodwill		1,759,898					1,733,722
		$	1,771,120				$	1,733,722

Amortization expense on intangible assets totaled approximately $133.1 million, $110.4 million and $94.9 million, respectively, for the years ended December 31, 2012, 2011 and 2010. In connection with the restructuring discussed more fully in Note 6, an abandonment charge of $2.0 million and $40.3 million related to discontinued projects was recorded in general and administrative, restructuring, integration and other in 2012 and 2011, respectively. The amortization of the in-process research and development will begin in 2013 as the projects are completed.

Amortization of intangibles for the next five years is expected to be approximately:




(in thousands)	Amortization
Years ended December 31:
2013	$	125,722
2014	$	124,836
2015	$	124,117
2016	$	121,195
2017	$	117,332

The changes in the carrying amount of goodwill for the years ended December 31, 2012 and 2011 are as follows:

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(in thousands)	Total
BALANCE AT DECEMBER 31, 2010	$	1,352,281
Goodwill acquired during the year	402,575
Earn-out and milestone payments	1,122
Purchase adjustments	615
Effect of foreign currency translation	(22,871		)
BALANCE AT DECEMBER 31, 2011	$	1,733,722
Goodwill acquired during the year	82,599
Earn-out and milestone payments	(36		)
Purchase adjustments	(70,034		)
Effect of foreign currency translation	13,647
BALANCE AT DECEMBER 31, 2012	$	1,759,898

The changes in the carrying amount of goodwill during the year ended December 31, 2012 resulted from the 2012 acquisitions, purchase price adjustments primarily related to the 2011 acquisitions, foreign currency translation and changes in the fair value of contingent consideration as discussed in Note 14. During 2011, changes in goodwill resulted primarily from 2011 acquisitions and foreign currency translation. Accumulated goodwill impairment totaled $1.6 million as of December 31, 2012 and 2011.

We occasionally enter into transactions which include the purchase, sale, or licensing of patented or non-patented technology as well as supply agreements, particularly in the areas of Pharma and Molecular Diagnostics. The agreements may be structured such that the transaction is required to be accounted for in accordance with ASC No. 845, Nonmonetary Transactions (“ASC No. 845”) and may include multiple deliverables accounted for accordance with ASC No. 605, Revenue Recognition.

During 2010, we entered into a series of transactions with a third party, under which we exchanged certain intangible assets in a nonmonetary exchange. We have accounted for this transaction under ASC No. 845, and recorded the intangible assets received at the fair value of the assets surrendered. As there is no observable market for these assets, we have performed this nonrecurring fair value measurement based on significant unobservable inputs (Level 3 as defined in Note 14). We have performed the fair value analysis using an income approach, including development of inputs such as future revenues to be generated under the assets, and future costs associated with product development, production, and distribution under the patents, in order to determine an exit price from the perspective of a market participant that holds the assets. As a result of nonmonetary transactions, we recorded intangible assets of $30.3 million, net sales of $11.0 million and deferred revenues of $19.3 million. In the same series of transactions, we agreed to supply certain products and the deferred revenue will be recognized ratably in connection with the supply of the products. Through December 31, 2011, we recognized $1.6 million of the deferred revenue. No amounts of deferred revenue were recognized during 2012.

12. Accrued and Other Liabilities

Accrued and other liabilities at December 31, 2012 and 2011 consist of the following:



(in thousands)	2012		2011
Accrued expenses	$	62,567	$	82,342
Payroll and related accruals	49,563		44,421
Deferred revenue	27,296		23,793
Accrued royalties	17,600		25,659
Fair value of derivative instruments	12,911		2,492
Accrued earn-outs and milestone payments	9,806		17,470
Accrued interest on long-term debt	7,008		7,383
Preacquisition contingencies assumed in acquisition	5,493		6,203
Current portion of capital lease obligations	4,203		4,006
Total accrued and other liabilities	$	196,447	$	213,769

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13. Derivatives and Hedging

Derivatives and Hedging

In the ordinary course of business, we use derivative instruments, including swaps, forwards and/or options, to manage potential losses from foreign currency exposures and variable rate debt. The principal objective of such derivative instruments is to minimize the risks and/or costs associated with global financial and operating activities. We do not utilize derivative or other financial instruments for trading or other speculative purposes. We recognize all derivatives as either assets or liabilities on the balance sheet on a gross basis, measure those instruments at fair value and recognize the change in fair value in earnings in the period of change, unless the derivative qualifies as an effective hedge that offsets certain exposures. We do not offset the fair value of derivative instruments with cash collateral held or received from the same counterparty under a master netting arrangement.

As of December 31, 2011 ~~and~~ ~~December 31, 2010~~, all derivatives that ~~qualify~~qualified for hedge accounting ~~are~~were cash-flow hedges. For derivative instruments that are designated and qualify as a cash flow hedge, the effective portion of the gain or loss on the derivative is reported as a component of other comprehensive income (loss) and reclassified into earnings in the same period or periods during which the hedged transaction affects earnings. Gains and losses on the derivative representing either hedge ineffectiveness or hedge components excluded from the assessment of effectiveness are recognized in current earnings. In ~~2011~~2012 and ~~2010~~2011, we did not record any hedge ineffectiveness related to any cash-flow hedges in earnings and did not discontinue any cash-flow hedges. ~~During the next 12 months, we expect that approximately~~ ~~$0.8 million~~ ~~of derivative losses included in accumulated other comprehensive income, based on their valuation as of~~ ~~December 31, 2011, will be reclassified into income.~~ The cash flows derived from derivatives, including those that are not designated as hedges, are classified in the operating section of the consolidated statements of cash ~~flows, in the same category~~flows. As of December 31, 2012 we did not have any derivatives that were accounted for as ~~the consolidated balance sheet account of the underlying item.~~hedging instruments.

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Foreign Currency Derivatives

As a globally active enterprise, we are subject to risks associated with fluctuations in foreign currencies in our ordinary operations. This includes foreign currency-denominated receivables, payables, debt, and other balance sheet positions including intercompany items. We manage balance sheet exposure on a group-wide basis primarily using foreign exchange forward contracts, foreign exchange options and cross-currency swaps.

~~We had been party to foreign currency forward contracts with an aggregate notional amount of~~ ~~$44.0 million~~, which were entered into in connection with the notes payable to QIAGEN Finance (see Note 16) and which qualify for hedge accounting as cash-flow hedges. We determined that no ineffectiveness exists related to these derivatives. However, the differences between spot and forward rates were excluded from the assessment of hedge effectiveness and included in interest income as it effectively constitutes the difference in the interest rates of the respective currency pairs. The contracts matured in July 2011 and had fair market values included in accrued and other liabilities in the accompanying consolidated balance sheet at ~~December 31, 2010~~ ~~of approximately~~ ~~$3.9 million~~.

In addition, we were party to cross-currency swaps which were entered into in connection with the notes payable to Euro Finance (see Note ~~16)~~15) and which qualified as cash-flow hedges with a notional amount of $120.0 million as of December 31, 2011 ~~and~~ ~~2010~~, which ~~mature~~matured in November 2012 and had fair market values of $0.7 million included in prepaid and other assets and $1.7 million included in accrued and other liabilities as of December 31, 2011 ~~and as of~~ ~~December 31, 2010~~ ~~had~~ ~~$4.6 million~~ ~~included in other long-term liabilities~~ in the accompanying consolidated balance sheets.

Undesignated Derivative Instruments

We are party to various foreign exchange forward and swap arrangements which had, at December 31, 2012, an aggregate notional value of approximately $574.5 million and fair values of $0.8 million and $12.9 million, which are included in prepaid and other assets and accrued and other liabilities, respectively, and which expire at various dates through April 2013. The transactions have been entered into to offset the effects from short-term balance sheet exposure to foreign currency exchange risk. Changes in the fair value of these arrangements have been recognized in other (expense) income, net.

We were party to various foreign exchange forward and swap arrangements which had, at December 31, 2011, an aggregate notional value of approximately $204.0 million and fair values of $~~5.6~~5.5 million and $0.8 million, which are included in prepaid and other assets and other liabilities, respectively, and which expire at various dates through April 2012. The transactions have been entered into to offset the effects from short-term balance sheet exposure to foreign currency exchange risk. Changes in the fair value of these arrangements have been recognized in other income, net.

~~We were party to various foreign exchange forward and swap arrangements which had, at~~ ~~December 31, 2010, an aggregate notional value of approximately~~ ~~$295.4 million~~ ~~and fair values of~~ ~~$0.7 million~~ ~~and~~ ~~$5.1 million, which are included in other assets~~accrued and other liabilities, respectively, and which expired at various dates through April ~~2011.~~2012. The transactions have been used to offset the effects from short-term balance sheet exposure to foreign currency exchange risk. Changes in the fair value of these arrangements have been recognized in other (expense) income, net.

Interest Rate Derivatives

We ~~use~~used interest rate derivative contracts on certain borrowing transactions to hedge fluctuating interest ~~rates.~~rates until October 2011. We ~~have~~ entered into interest rate swaps in which we ~~agree~~agreed to exchange, at specified intervals, the difference between fixed and floating interest amounts calculated by reference to an agreed-upon notional principal amount. ~~During 2008, we entered into interest rate swaps, which effectively fixed the variable interest rates on~~ ~~$200.0 million~~ ~~of our variable rate debt and qualify for hedge accounting as cash-flow hedges. We have determined that no ineffectiveness exists related to these swaps. During~~ ~~2010~~, ~~$100.0 million~~ ~~of the swaps matured. The remaining~~ ~~$100.0 million~~ ~~matured in~~ ~~October 2011. As of~~ ~~December 31, 2010~~ ~~these swaps had an aggregate fair value of~~ ~~$2.7 million, which is recorded in accrued and other liabilities in the accompanying consolidated balance sheets.~~

Fair Values of Derivative Instruments

The following table summarizes the fair value amounts of derivative instruments reported in the consolidated balance sheets as of December 31, ~~2011~~2012 and ~~2010~~2011:

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	Derivatives in Asset Positions Fair value				Derivatives in Liability Positions Fair value						Derivatives in Asset Positions Fair value				Derivatives in Liability Positions Fair value
(in thousands)	12/31/2011		12/31/2010		12/31/2011			12/31/2010			12/31/2012		12/31/2011		12/31/2012			12/31/2011
Derivative instruments designated as hedges
Interest rate contracts	$	—	$	—	$	—		$	(2,663	)	$	—	$	—	$	—		$	—
Foreign exchange contracts	658		—		(1,723		)	(8,452		)	—		658		—			(1,723		)
Total derivative instruments designated as hedges	$	658	$	—	$	(1,723	)	$	(11,115	)	$	—	$	658	$	—		$	(1,723	)
Undesignated derivative instruments
Foreign exchange contracts	$	5,489	$	677	$	(769	)	$	(5,113	)	$	833	$	5,489	$	(12,911	)	$	(769	)
Total derivative instruments	$	6,147	$	677	$	(2,492	)	$	(16,228	)	$	833	$	6,147	$	(12,911	)	$	(2,492	)

Gains and Losses on Derivative Instruments

The following tables summarize the locations and gains on derivative instruments for the years ended December 31, ~~2011~~2012 and ~~2010~~2011:


Year-Ended December 31, 2011 (in thousands)	Gain/(loss) recognized in AOCI		Location of (gain) loss in income statement	(Gain) loss reclassified from AOCI into income			Gain recognized in income
Year-Ended December 31, 2012 (in thousands)									Gain/(loss) recognized in AOCI		Location of (gain) loss in income statement	(Gain) loss reclassified from AOCI into income		Gain recognized in income
Cash-flow hedges
Interest rate contracts	$	2,721	Interest expense	$	—		$	—	$	—	Interest expense	$	—	$	—
Foreign exchange contracts	2,696		Other income, net	(3,961		)	—		305		Other expense / income, net	781		—
Total	$	5,417		$	(3,961	)	$	—	$	305		$	781	$	—
Undesignated derivative instruments
Foreign exchange contracts	$	—	Other income, net	$	—		$	14,194	$	—	Other expense / income, net	$	—	$	(13,456	)


Year-Ended December 31, 2010 (in thousands)	Gain/(loss) recognized in AOCI		Location of (gain) loss in income statement	(Gain) loss reclassified from AOCI into income			Loss recognized in income
Year-Ended December 31, 2011 (in thousands)										Gain/(loss) recognized in AOCI		Location of (gain) loss in income statement	(Gain) loss reclassified from AOCI into income			Loss recognized in income
Cash-flow hedges
Interest rate contracts	$	3,611	Interest expense	$	—		n/a			$	2,721	Interest expense	$	—		n/a
Foreign exchange contracts	11,025		Other income, net	(8,874		)	n/a			2,696		Other expense / income, net	(3,961		)	n/a
Total	$	14,636		$	(8,874	)	n/a			$	5,417		$	(3,961	)	n/a
Undesignated derivative instruments
Foreign exchange contracts	n/a		Other income, net	n/a			$	(2,239	)	n/a		Other expense / income, net	n/a			$	14,194

The amounts noted in the table above for accumulated other comprehensive income (AOCI) do not include any adjustment for the impact of deferred income taxes.


8.	~~Fair Value Measurements~~

14. Fair Value Measurements

Assets and liabilities are measured at fair value according to a three-tier fair value hierarchy which prioritizes the inputs used in measuring fair value as follows:

Level 1. Observable inputs, such as quoted prices in active markets;

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Level 2. Inputs, other than the quoted price in active markets, that are observable either directly or indirectly; and

Level 3. Unobservable inputs in which there is little or no market data, which require the reporting entity to develop

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its own assumptions.

Our assets and liabilities measured at fair value on a recurring basis consist of short-term investments, which are classified in Level 1 and Level 2 of the fair value hierarchy, derivative contracts used to hedge currency and interest rate risk, which are classified in Level 2 of the fair value hierarchy, and contingent consideration accruals, which are classified in Level 3 of the fair value hierarchy, and are shown in the tables below. In determining fair value for Level 2 instruments, we apply a market approach, using quoted active market prices relevant to the particular instrument under valuation, giving consideration to the credit risk of both the respective counterparty to the contract and the Company. To determine our credit risk we estimated our credit rating by benchmarking the price of outstanding debt to publicly-available comparable data from rated companies. Using the estimated rating, our credit risk was quantified by reference to publicly-traded debt with a corresponding rating. We value contingent consideration liabilities using Level 3 unobservable inputs, applying the income approach, such as the discounted cash flow technique, or the probability-weighted scenario method. Contingent consideration arrangements obligate us to pay the sellers of an acquired entity if specified future events occur or conditions are met such as the achievement of technological or revenue milestones. We use various key assumptions, such as the probability of achievement of the milestones and the discount rate, to represent the non-performing risk factors and time value when applying the income approach. We regularly review the fair value of the contingent consideration, and reflect any change in the accrual in the ~~condensed~~ consolidated ~~statement~~statements of income in the line items commensurate with the underlying nature of milestone arrangements.

The following table presents our fair value hierarchy for our financial assets and liabilities measured at fair value on a recurring basis as of December 31, ~~2011~~2012 and ~~2010~~2011:


	As of December 31, 2011								As of December 31, 2010								As of December 31, 2012								As of December 31, 2011
(in thousands)	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Short-term investments	$	9,290	$	45,287	$	—	$	54,577	$	70,000	$	36,077	$	—	$	106,077	$	7,989	$	82,462	$	—	$	90,451	$	9,290	$	45,287	$	—	$	54,577
Foreign exchange contracts	—		6,147		—		6,147		—		677		—		677		—		833		—		833		—		6,147		—		6,147
	$	9,290	$	51,434	$	—	$	60,724	$	70,000	$	36,754	$	—	$	106,754	$	7,989	$	83,295	$	—	$	91,284	$	9,290	$	51,434	$	—	$	60,724
Liabilities:
Foreign exchange contracts	$	—	$	2,492	$	—	$	2,492	$	—	$	13,565	$	—	$	13,565	$	—	$	12,911	$	—	$	12,911	$	—	$	2,492	$	—	$	2,492
Interest rate contracts	—		—		—		—		—		2,663		—		2,663
Contingent Consideration	—		—		38,646		38,646		—		—		22,510		22,510		—		—		18,983		18,983		—		—		38,646		38,646
	$	—	$	2,492	$	38,646	$	41,138	$	—	$	16,228	$	22,510	$	38,738	$	—	$	12,911	$	18,983	$	31,894	$	—	$	2,492	$	38,646	$	41,138

For liabilities with Level 3 inputs, the following table summarizes the activity as of December 31, ~~2011~~2012:


(in thousands) (unaudited)	Fair Value Measurements Using Significant Unobservable Inputs (Level 3) Contingent Consideration			Fair Value Measurements Using Significant Unobservable Inputs (Level 3) Contingent Consideration
Beginning Balance at December 31, 2010	$	22,510
BALANCE AT DECEMBER 31, 2010				$	22,510
Additions from acquisitions	24,885			24,885
Payments	(9,065		)	(9,065		)
Total loss included in earnings	253
Loss included in earnings				253
Foreign currency translation	63			63
Ending balance at December 31, 2011	$	38,646
BALANCE AT DECEMBER 31, 2011				$	38,646
Additions from acquisitions				16,875
Payments				(6,008		)
Gain included in earnings				(11,463		)
Reversals				(19,129		)
Foreign currency translation				62
BALANCE AT DECEMBER 31, 2012				$	18,983

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For the year ended December 31, 2012, the gain of $11.5 million was recognized in earnings as follows: $6.7 million in cost of sales and $4.8 million in general and administrative, restructuring, integration and other. During 2012, a reduction in the fair value of contingent consideration of $19.1 million was recorded against goodwill shortly after the acquisition and during the measurement period.

The carrying values of financial instruments, including cash and equivalents, accounts receivable, accounts payable and other accrued liabilities, approximate their fair values due to their short-term maturities. The estimated fair value of long-term debt as disclosed in Note 1615 was based on current interest rates for similar types of borrowings. The estimated fair values may

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not represent actual values of the financial instruments that could be realized as of the balance sheet date or that will be realized in the future. There were no fair value adjustments in the years ended December 31, ~~2011~~2012 and ~~2010~~2011 for nonfinancial assets or liabilities required to be measured at fair value on a nonrecurring ~~basis.~~basis other than the impairment of a cost-method investment as discussed in Note 10.


9.	~~Short-term Investments~~

At ~~December 31, 2011, we had EUR~~ ~~35.0 million~~ (~~$45.3 million~~ as15. Lines of ~~December 31, 2011) of loan note receivables due from financial institutions. These loan receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market~~Credit and ~~are carried at fair market value, which is equal to the cost. These loans consist of~~ ~~$25.9 million~~ ~~which finally matures in November 2013, and~~ ~~$19.4 million~~ which finally matures in October 2013 with put option rights on a quarterly basis. Interest income is determined using the effective interest rate method. These loans are classified as current assets in the accompanying consolidated balance sheets since we may put the loans at our discretion.Debt

At ~~December 31, 2011, we also had EUR~~ ~~7.2 million~~ (~~$9.3 million) in term deposits with final maturities between July 2012 and December 2014. The deposits can be withdrawn at the end of each quarter without penalty.~~

At ~~December 31, 2010, short-term investments consisted of $70.0 million~~ ~~of investments in short-term funds that have a fixed maturity date. Thereof $50.0 million~~ ~~matured in~~ ~~January 2011~~ ~~and $20.0 million~~ ~~matured in~~ ~~May 2011. These fund investments are carried at fair market value, which is equal to the cost. Additionally, we had EUR~~ ~~27.0 million~~ ($~~36.1 million~~ ~~as of~~ ~~December 31, 2010~~) of loan note receivables due from financial institutions. These loan receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market. These loans consist of $~~9.4 million~~ ~~which matured in~~ ~~February 2011, and $26.7 million~~ ~~which matures in~~ ~~November 2013~~ ~~with put option rights on a quarterly basis beginning in~~ ~~February 2011~~. Interest income is determined using the effective interest rate method. These loans are classified as current assets in the accompanying consolidated balance sheets since we may put the loans at our discretion.

~~For the year ended~~ ~~December 31, 2011~~ ~~and~~ ~~2010, proceeds from sales of short term investments totaled $242.6 million~~ ~~and~~ $~~44.0 million, respectively. There were no realized gains or losses during~~ ~~2011~~ or ~~2010~~.


~~10.~~	~~Prepaid Expenses and Other Current Assets~~

~~Prepaid expenses and other current assets are summarized as follows as of~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~:

(in thousands) 2011 2010
Prepaid expenses $ 27,832
$ 24,061
Amounts held in escrow in connection with acquisitions 7,026
27,006
Value added tax 9,488
7,039
Other receivables 14,709
6,296
$ 59,055
$ 64,402


~~11.~~	~~Property, Plant and Equipment~~

~~Property, plant and equipment, including equipment acquired under capital lease obligations, are summarized as follows as of~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~:

(in thousands)
Estimated
useful life
(in years)
2011 2010
Land —
$ 15,686
$ 16,053
Buildings and improvements 1-40
275,529
232,946
Machinery and equipment 1-15
176,662
157,973
Computer software 1-10
65,344
53,948
Furniture and office equipment 1-15
76,809
75,030
Construction in progress —
51,827
59,418

661,857
595,368
Less: Accumulated depreciation and amortization
(290,065 ) (249,704 )
Property, plant and equipment, net
$ 371,792
$ 345,664

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~~Amortization of assets acquired under capital lease obligations is included within accumulated depreciation and amortization above for the years ended~~ ~~December 31, 2011~~ ~~and~~ ~~2010, respectively. For the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~ ~~depreciation and amortization expense totaled~~ ~~$57.0 million~~, ~~$47.9 million~~ ~~and~~ ~~$42.0 million, respectively. Repairs and maintenance expense was~~ ~~$12.9 million~~, ~~$11.8 million~~ ~~and~~ ~~$10.9 million~~ in ~~2011~~, ~~2010~~ ~~and~~ ~~2009, respectively. For the year ended~~ ~~December 31, 2011~~ ~~and~~ ~~2010, construction in progress includes amounts related to the construction of new facilities in Germany and the United States. For the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009, interest capitalized in connection with construction projects was not significant.~~


~~12.~~	~~Investments~~

We have made strategic investments in certain companies that are accounted for using the equity or cost method of accounting. The method of accounting for an investment depends on the level of influence. We monitor changes in circumstances that may require a reassessment of the level of influence. We periodically review the carrying value of these investments for impairment, considering factors such as the most recent stock transactions and book values from the recent financial statements. The fair value of cost and equity-method investments is estimated when there are identified events or changes in circumstances that may have an impact on the fair value of the investment. A summary of these investments, which are included in other assets, is as follows:

Equity investments
as of December 31,

Share of income (loss)
for the years ended December 31,
Company (in thousands)
Ownership
Percentage
2011 2010 2011 2010 2009
PreAnalytiX GmbH 50.00 % $ 15,723
$ 15,308
$ 390
$ 2,969
$ 2,887
QBM Cell Science 19.50 % $ 395
$ 405
$ (10 ) $ 11
$ (49 )
QIAGEN Finance 100.00 % $ 252
$ 949
$ 103
$ 131
$ 115
QIAGEN Euro Finance 100.00 % $ 622
$ 1,306
$ 266
$ 273
$ 300
Pyrobett 19.00 % $ 3,749
$ 3,927
$ (178 ) $ (73 ) $ —
Dx Assays Pte Ltd 33.30 % $ —
$ —
$ —
$ —
$ (316 )
Scandinavian Gene Synthesis AB 40.00 % $ 15,714
$ —
$ 23
$ —
$ —
Peak-Service 40.00 % $ 20
$ —
$ —
$ —
$ —

~~We have a~~ ~~50%~~ interest in a joint venture company, PreAnalytiX GmbH, for which we are not the primary beneficiary. Thus, the investment is accounted for under the equity method. PreAnalytiX was formed to develop, manufacture and market integrated systems for the collection, stabilization and purification of nucleic acids for molecular diagnostic testing. At present, our maximum exposure to loss as a result of our involvement with PreAnalytiX is limited to our share of losses from the equity method investment itself.

~~We have a~~ ~~100%~~ ~~interest in QIAGEN Finance (Luxembourg) S.A. (QIAGEN Finance) and QIAGEN Euro Finance (Luxembourg) S.A. (Euro Finance), companies established for the purpose of issuing convertible debt in~~ ~~2004~~ ~~and~~ ~~2006, respectively. In~~ ~~August 2004, we issued $150.0 million~~ of ~~1.5%~~ ~~Senior Convertible Notes (2004 Notes) due in~~ ~~2024~~ ~~through QIAGEN Finance. In~~ ~~May 2006, we completed the offering of $300.0 million~~ of ~~3.25%~~ ~~Senior Convertible Notes (2006 Notes) due in~~ ~~2026~~ ~~through Euro Finance. The proceeds of the~~ ~~2004~~ ~~and~~ ~~2006~~ Notes were loaned to subsidiaries within the consolidated QIAGEN N.V. group. QIAGEN N.V. has guaranteed all of these Notes, and has agreements with each of QIAGEN Finance and Euro Finance to issue common shares to the investors in the event of conversion of any of the Notes. QIAGEN Finance and Euro Finance are variable interest entities. We are not the primary beneficiary, therefore neither is consolidated. Accordingly, the ~~2004~~ ~~and~~ ~~2006~~ convertible debt is not included in the consolidated statements of QIAGEN N.V., though QIAGEN N.V. does report the full obligation of the debt through its liabilities to QIAGEN Finance and Euro Finance. QIAGEN N.V. accounts for its investments in QIAGEN Finance and Euro Finance as equity investments and accordingly records ~~100%~~ of the profit or loss of QIAGEN Finance and Euro Finance in the gain or loss from equity method investees. At present, our maximum exposure to loss as a result of our involvement with QIAGEN Finance and Euro Finance is limited to our share of losses from the equity method investments.

In ~~2010, we made a~~ ~~$4.0 million~~ ~~investment in Pyrobett, a company located in Singapore which performs research and development activities related to the development of instruments for use in life sciences.~~

~~During the second quarter of~~ ~~2011, we paid~~ ~~$9.7 million~~ ~~for a~~ ~~40%~~ ~~share together with a~~ ~~$6.7 million~~ ~~advance payment towards the potential future acquisition of the remaining~~ ~~60%~~ ~~of Scandinavian Gene Synthesis AB. We hold a call option,~~

~~F-26~~

~~Table of Contents~~

~~exercisable for two months after October 2012 to acquire the remaining~~ ~~60%~~ ~~of shares. Conversely, the sellers in this transaction hold a put option to sell the remaining~~ ~~60%~~ ~~of shares to us, exercisable for two months after October 2012. In case neither the put nor the call option is exercised the sellers must repay~~ ~~$6.7 million. The investment is accounted for under the equity-method.~~

At ~~December 31, 2011~~ ~~and~~ ~~2010, we had a total of cost-method investments in non-publicly traded companies with carrying amounts of~~ ~~$6.8 million~~ ~~and~~ ~~$3.4 million~~, respectively, which are included in other assets. The fair-value of these cost-method investments are not estimated as there are no identified events or changes in circumstances that may have a significant adverse effect on the fair value of the investment.

At ~~December 31, 2011~~ ~~and~~ ~~2010, we had a loan receivable of~~ ~~$1.5 million~~ ~~and~~ ~~$1.6 million, respectively, included in other long-term assets, due from Dx Assays, which bears interest at~~ ~~15%~~ ~~and is due in March 2013.~~

~~During~~ ~~2009, we sold our investment in a privately-held company which had been accounted for under the cost-method of accounting, and realized a gain of~~ ~~$10.5 million~~ in ~~2009. The proceeds were received in January~~ ~~2010, and an additional gain of~~ ~~$0.6 million~~ ~~was recorded in~~ ~~2010~~ ~~following the receipt of additional proceeds which had been held in escrow.~~


~~13.~~	~~Intangible Assets~~

~~The following sets forth the acquired intangible assets by major asset class as of~~ ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010~~:

2011 2010
(in thousands)
Weighted
Average
Life

Gross
Carrying
Amount

Accumulated
Amortization

Gross
Carrying
Amount

Accumulated
Amortization
Amortized Intangible Assets:
Patent and license rights 11.8
$ 294,854
$ (115,310 ) $ 289,199
$ (88,275 )
Developed technology 10.3
605,847
(210,022 ) 501,287
(157,838 )
Customer base, trademarks, in-process R&D and non-compete agreements 10.6
336,216
(92,098 ) 275,167
(66,213 )
$ 1,236,917
$ (417,430 ) $ 1,065,653
$ (312,326 )
Unamortized Intangible Assets:

Goodwill $ 1,733,722
$ 1,352,281

~~In connection with the acquisitions as more fully discussed in Note 4, approximately $0.6 million~~ ~~of purchase price was allocated to purchased in-process research and development and capitalized in~~ ~~2010. No purchased in-process research and development was capitalized in 2011. During~~ ~~2009~~, ~~$1.6 million~~ of goodwill from a previous acquisition was written off following the acquisition of DxS Ltd. and is recorded in general and administrative, integration and other expenses in the accompanying consolidated statements of income. Accumulated goodwill impairment totaled ~~$1.6 million~~ ~~as of December 31, 2011 and 2010.~~

~~Amortization expense on intangible assets totaled approximately $110.4 million, $94.9 million~~ ~~and $78.4 million, respectively, for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009. During 2011, in connection with the restructuring discussed more fully in Note 5, an abandonment charge of~~ ~~$42.1 million~~ ~~related to discontinued projects was recorded in general, administrative and other. During~~ ~~2009, additional amortization of $5.0 million~~ ~~was recorded in cost of sales related to the impairment of developed technology, which was triggered by the acquisition of DxS and SABiosciences.~~

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~~Table of Contents~~

~~Amortization of intangibles for the next five years is expected to be approximately:~~

(in thousands) Amortization
Years ended December 31:
2012 $ 121,763
2013 $ 116,004
2014 $ 115,021
2015 $ 113,826
2016 $ 110,979

~~The changes in the carrying amount of goodwill for the years ended~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~are as follows:~~

(in thousands) Total
BALANCE AT DECEMBER 31, 2009 $ 1,337,064
Earn-out and milestone payments 2,983
Purchase adjustments 579
Effect of foreign currency translation 11,655
BALANCE AT DECEMBER 31, 2010 $ 1,352,281
Goodwill acquired during the year 402,575
Earn-out and milestone payments 1,122
Purchase adjustments 615
Effect of foreign currency translation (22,871 )
BALANCE AT DECEMBER 31, 2011 $ 1,733,722

~~The changes in the carrying amount of goodwill during the year ended~~ ~~December 31, 2011~~ ~~resulted from the~~ ~~2011~~ ~~acquisitions, foreign currency translation and purchase price adjustments primarily related to the 2010 acquisitions. During~~ ~~2010, changes in goodwill resulted from earn-out and milestone payments, purchase price adjustments related to the~~ ~~2009~~ ~~acquisitions and foreign currency translation.~~

We occasionally enter into transactions which include the purchase, sale, or licensing of patented or non-patented technology as well as supply agreements, particularly in the areas of Pharma and Molecular Diagnostics. The agreements may be structured such that the transaction is required to be accounted for in accordance with ASC No. 845, ~~Nonmonetary Transactions~~ ~~(“ASC No. 845”) and may include multiple deliverables accounted for accordance with ASC No. 605,~~ ~~Revenue Recognition~~.

~~During~~ ~~2010~~, we entered into a series of transactions with a third party, under which we exchanged certain intangible assets in a nonmonetary exchange. We have accounted for this transaction under ASC No. 845, and recorded the intangible assets received at the fair value of the assets surrendered. As there is no observable market for these assets, we have performed this nonrecurring fair value measurement based on significant unobservable inputs (Level 3 as defined in Note 8). We have performed the fair value analysis using an income approach, including development of inputs such as future revenues to be generated under the assets, and future costs associated with product development, production, and distribution under the patents, in order to determine an exit price from the perspective of a market participant that holds the assets. As a result of nonmonetary transactions, we recorded intangible assets of $~~30.3 million, net sales of $11.0 million~~ ~~and deferred revenues of $19.3 million. In the same series of transactions, we agreed to supply certain products and the deferred revenue will be recognized ratably in connection with the supply of the products. During~~ ~~2011, we recognized~~ ~~$1.6 million~~ ~~of the deferred revenue.~~

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~~Table of Contents~~


~~14.~~	~~Income Taxes~~

~~Income before provision for income taxes for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~ ~~consisted of:~~

(in thousands) 2011 2010 2009
Pretax income in The Netherlands $ 30,232
$ 55,431
$ 72,190
Pretax income from foreign operations 65,980
117,690
100,140
$ 96,212
$ 173,121
$ 172,330

~~The provisions for income taxes for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~ ~~are as follows:~~

(in thousands) 2011 2010 2009
Current—The Netherlands $ 6,752
$ 12,265
$ 12,633
—Foreign 26,372
36,487
32,539
33,124
48,752
45,172
Deferred—The Netherlands —
—
—
—Foreign (31,861 ) (19,942 ) (10,609 )
(31,861 ) (19,942 ) (10,609 )
Total provision for income taxes $ 1,263
$ 28,810
$ 34,563

~~The Netherlands statutory income tax rate for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~ ~~was~~ ~~25%~~, ~~25.5%~~ ~~and~~ ~~25.5%. The principal items comprising the differences between income taxes computed at The Netherlands statutory rate and the effective tax rate for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~ ~~are as follows:~~

2011 2010 2009
(in thousands) Amount Percent Amount Percent Amount Percent
Income taxes at The Netherlands statutory rate $ 24,053
25.0 % $ 44,146
25.5 % $ 43,944
25.5 %
Earnings of subsidiaries taxed at different rates 3,204
3.3
7,710
4.5
4,710
2.7
Tax impact from permanent items 5,989
6.2
3,295
1.9
—
—
Tax impact from tax exempt income (23,382 ) (24.3 ) (10,283 ) (6.0 ) (11,039 ) (6.4 )
Tax contingencies, net (1,675 ) (1.7 ) (1,269 ) (0.7 ) 1,774
1.0
Taxes due to changes in tax rates (3,521 ) (3.7 ) (1,400 ) (0.8 ) (3,671 ) (2.0 )
Restructuring —
—
(12,903 ) (7.5 ) —
—
Prior year taxes (2,632 ) (2.7 ) 476
0.3
912
0.5
Other items, net (773 ) (0.8 ) (962 ) (0.6 ) (2,067 ) (1.2 )
Total provision for income taxes $ 1,263
1.3 % $ 28,810
16.6 % $ 34,563
20.1 %

We conduct business globally and, as a result, file numerous consolidated and separate income tax returns in the Netherlands, Germany, Switzerland and the U.S. federal jurisdiction, as well as in various other state and foreign jurisdictions. In the normal course of business, we are subject to examination by taxing authorities throughout the world. Our tax years since ~~2000~~ ~~are open for income tax examinations by tax authorities. Our subsidiaries, with few exceptions, are no longer subject to income tax examinations by tax authorities for years before~~ ~~2007. The U.S. consolidated group is subject to federal and most state income tax examinations by tax authorities beginning the year ending~~ ~~December 31, 2007~~ ~~through the current period.~~

~~During 2011, the tax authorities audited the income tax returns of our German subsidiaries for the tax years~~ ~~2006~~ ~~through~~ ~~2009. The outcome of the audit resulted in a current tax liability of~~ ~~$5.3 million~~ primarily related to the timing of certain deductions. As such, a deferred tax asset and deferred tax benefit was recorded that substantially offset the current year liability and expense. As a result of the audit being settled in 2011, the Company released ~~$2.3 million~~ ~~of tax reserves through income tax expense.~~

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~~We do not currently anticipate that our existing reserves related to uncertain tax positions as of~~ ~~December 31, 2011~~ ~~will significantly increase or decrease during the twelve-month period ending~~ ~~December 31, 2012~~; however, various events could cause our current expectations to change in the future. The majority of these uncertain tax positions, if ever recognized in the financial statements, would be recorded in the statement of operations as part of the income tax provision.

~~Changes in the gross amount of unrecognized tax benefits are as follows:~~

(in thousands)
Unrecognized
Tax
Benefits

Balance at December 31, 2009 $ 10,338
Additions based on tax positions related to the current year 322
Additions for tax positions of prior years 124
Settlements with taxing authorities (592 )
Reductions due to lapse of statute of limitations (1,361 )
Decrease from currency translation (158 )
Balance at December 31, 2010 $ 8,673
Additions based on tax positions related to the current year $ 757
Additions for tax positions of prior years 31
Settlements with taxing authorities (2,257 )
Reductions due to lapse of statute of limitations (207 )
Decrease from currency translation (62 )
Balance at December 31, 2011 $ 6,935

At ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010, our net unrecognized tax benefits totaled approximately~~ ~~$6.3 million~~ ~~and~~ ~~$8.0 million, respectively, of which~~ ~~$6.3 million~~ ~~in benefits, if recognized, would favorably, affect our effective tax rate in any future period. It is possible that approximately~~ ~~$0.5 million~~ ~~of the unrecognized tax benefits may be released during the next~~ 12 ~~months due to lapse of statute of limitations or settlements with tax authorities.~~

~~Our policy is to recognize interest accrued related to unrecognized tax benefits in interest expense and penalties within tax provision expense. At~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~we have net interest expense and penalties of~~ ~~$0.1 million. At~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~we have accrued interest of~~ ~~$0.5 million~~ ~~and~~ ~~$0.4 million, respectively, that are not included in the table above.~~

~~We have recorded net deferred tax liabilities of~~ ~~$181.5 million~~ ~~and~~ ~~$163.3 million~~ at ~~December 31, 2011~~ ~~and~~ ~~2010, respectively, which are reflected on the consolidated balance sheets at~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~as follows:~~

(in thousands) 2011 2010
Current deferred tax asset $ 31,652
$ 30,731
Current deferred tax liabilities (32,883 ) (30,504 )
Non-current deferred tax asset 26,866
37,182
Non-current deferred tax liabilities (207,112 ) (200,667 )
Net deferred tax liabilities $ (181,477 ) $ (163,258 )

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~~Table of Contents~~

~~The components of the net deferred tax liability at~~ ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010~~ ~~are as follows:~~

2011 2010
(in thousands)
Deferred
Tax Assets

Deferred
Tax Liability

Deferred
Tax Assets

Deferred
Tax Liability
Net operating loss carry forwards $ 10,389
$ —
$ 13,658
$ —
Accrued and other liabilities 25,981
(65 ) 30,138
(6,487 )
Inventories 3,106
(1,578 ) 3,134
(1,915 )
Allowance for bad debts 726
(471 ) 744
(473 )
Currency revaluation 1,846
—
2,303
(3,588 )
Depreciation and amortization 124
(19,854 ) 51
(9,272 )
Tax credits 6,848
—
9,067
—
Unremitted profits and earnings —
(1,175 ) —
(1,042 )
Intangibles 2,523
(218,027 ) 1,228
(206,481 )
Equity awards 7,289
—
5,624
—
Other 6,553
(1,432 ) 7,342
(1,913 )
Valuation allowance (4,260 ) —
(5,376 ) —
$ 61,125
$ (242,602 ) $ 67,913
$ (231,171 )
Net deferred tax liabilities $ (181,477 ) $ (163,258 )

At ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010, we had~~ ~~$39.4 million~~ ~~and~~ ~~$57.6 million~~ ~~in total foreign net operating losses. At~~ ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010, we had~~ ~~$5.1 million~~ ~~and~~ ~~$23.5 million~~ ~~of U.S. federal net operating loss (NOL) carryforwards. At~~ ~~December 31, 2011~~, the entire NOLs in the U.S. are subject to limitations under Section 382 of the Internal Revenue Code but all losses subject to IRC 382 limitation are expected to be utilized before they expire. The net operating losses in the U.S. will expire beginning ~~December 31, 2021~~ ~~through~~ ~~December 31, 2027~~ ~~. As of~~ ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010, we had other foreign NOL carryforwards totaling approximately~~ ~~$34.3 million~~ ~~and~~ ~~$34.1 million, respectively. These NOLs were primarily generated from acquisitions and operating losses from our subsidiaries. A portion of the foreign net operating losses will be expiring beginning~~ ~~December 31, 2012. The valuation allowance amounts for the years ended~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~are~~ ~~$4.3 million~~ ~~and~~ ~~$5.4 million, respectively. We had a decrease of~~ ~~$1.1 million~~ in ~~2011~~ ~~largely due to the release of the valuation allowance on assets that were used to offset current tax liability. In~~ ~~2010, the company had a decrease of valuation allowance of~~ ~~$10.2 million~~ ~~whereby the tax effects were eliminated by the assets that were no longer available for future use as a result of intercompany sale of assets.~~

~~As of~~ ~~December 31, 2011~~, residual Netherlands income taxes have not been provided on the undistributed earnings of the majority of our foreign subsidiaries as these earnings are considered to be either permanently reinvested or can be repatriated tax free. We have ~~$17.8 million~~ ~~dollars of undistributed earnings that we do not consider permanently reinvested and have recorded deferred income taxes or withholding taxes at~~ ~~December 31, 2011~~ ~~and~~ ~~December 31, 2010, of approximately~~ ~~$1.2 million~~ ~~and~~ ~~$1.0 million, respectively. All other undistributed earnings can be both distributed in a tax efficient manner and are considered permanently reinvested~~

~~There are no income tax consequences regarding payment of dividends to our shareholders. To date, we have never paid dividends.~~

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~~Table of Contents~~


~~15.~~	~~Accrued and Other Liabilities~~

~~Accrued and other liabilities at~~ ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~consist of the following:~~

(in thousands) 2011 2010
Accrued expenses $ 82,342
$ 54,122
Payroll and related accruals 44,421
42,503
Preacquisition contingencies assumed in acquisition 6,203
28,679
Accrued earn-outs and milestone payments 17,470
24,808
Swaps and forwards 2,492
11,685
Accrued royalties 25,659
16,400
Deferred revenue 23,793
20,973
Accrued interest on long-term debt 7,383
6,296
Current portion of capital lease obligations 4,006
3,588
Total accrued and other liabilities $ 213,769
$ 209,054


~~16.~~	~~Lines of Credit and Debt~~

The credit facilities available at December 31, ~~2011~~2012 total €~~406.6~~438.0 million (approximately $~~526.1~~577.9 million). This includes a €400.0 million syndicated multi-currency revolving credit facility expiring December 2016 of which ~~€110.0 million~~ ~~(approximately~~ ~~$142.3 million) was~~no amounts were utilized at December 31, ~~2011~~2012, and four other lines of credit amounting to €~~6.6~~38.0 million with no expiration date, none of which were utilized as of December 31, ~~2011~~2012. The €400.0 million facility can be utilized in euro, U.K pound or U.S. dollar and bears interest of 0.8% to 2.35% above three months EURIBOR, or LIBOR in relation to any loan not in euro, and is offered with interest periods of one, two, three, six or twelve months. The commitment fee is calculated based on 35% of the applicable margin. NoIn 2012, $1.1 million of commitment fees were ~~paid in~~ ~~2011~~.paid. The revolving facility agreement contains certain financial and non-financial covenants, including but not limited to, restrictions on the encumbrance of assets and the maintenance of certain financial ratios. We were in compliance with these covenants at December 31, ~~2011. There was no significant outstanding line of credit or short-term borrowings as of~~ ~~December 31, 2010~~2012. The credit facilities are for general corporate purposes.

In October 2012, we completed a private placement through the issuance of new senior unsecured notes at a total amount of $400 million with a weighted average interest rate of 3.66% (settled on October 16, 2012). The notes were issued in three series: (1) $73 million7-year term due in 2019 (3.19%); (2) $300 million10-year term due in 2022 (3.75%); and (3) $27 million12-year term due in 2024 (3.90%). We paid $2.1 million in debt issue costs which will be amortized through interest expense over the lifetime of the notes. The note purchase agreement contains certain financial and non-financial covenants, including but not limited to, restrictions on priority indebtedness and the maintenance of certain financial ratios. We were in compliance with these covenants at December 31, 2012. The carrying values of these Senior Notes totaling $400.0 million approximates fair value as of December 31, 2012 as neither the Treasury rates or credit spreads have changed significantly since the issuance date in October 2012.

Approximately €170 million (approximately $220 million) of proceeds from the notes were used to repay amounts outstanding under our short-term revolving credit facility. The remainder of the proceeds provides additional resources to support QIAGEN's longer-term business expansion.

At December 31, ~~2011~~2012, total long-term debt was approximately $~~447.6~~847.0 million, $~~1.6~~0.9 million of which is current. We believe that funds from operations, existing cash and cash equivalents, short-term investments and availability of financing facilities as needed, will be sufficient to fund our debt repayments coming due in ~~2012~~.2013.

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Table of Contents

Total long-term debt consists of the following:

(in thousands) December 31, 2011 December 31, 2010
$500 million note payable bearing interest at LIBOR plus a variable margin, repaid in 2011 $ —
$ 425,000
Notes payable to QIAGEN Euro Finance bearing interest at an effective rate of 3.97% due in December 2014 300,000
300,000
Notes payable to QIAGEN Finance bearing interest at an effective rate of 1.84% due in February 2024 145,000
145,000
R&D-related loan bearing interest at 3.50% due in 2013 2,103
3,006
Production-related loans bearing interest at an effective rates of 4.57% and 6.28% due in May and November 2015 519
—
Total long-term debt 447,622
873,006
Less current portion 1,617
75,835
Long-term portion $ 446,005
$ 797,171



(in thousands)	December 31, 2012		December 31, 2011
Notes payable to QIAGEN Euro Finance bearing interest at an effective rate of 3.7% due in May 2026	$	300,000	$	300,000
Notes payable to QIAGEN Finance bearing interest at an effective rate of 1.8% due in February 2024	145,000		145,000
3.19% Series A Senior Notes due October 16, 2019	73,000		—
3.75% Series B Senior Notes due October 16, 2022	300,000		—
3.90% Series C Senior Notes due October 16, 2024	27,000		—
Other notes payable bearing interest up to 6.28% and due through November 2015	1,992		2,622
Total long-term debt	846,992		447,622
Less current portion	948		1,617
Long-term portion	$	846,044	$	446,005

~~Ipsogen S.A., acquired in~~ ~~July 2011~~ ~~as discussed in Note 4 above, carries two long-term bank debts. The first loan, effective as of~~ ~~May 25, 2009, was for~~ ~~€0.3 million, having an effective rate of~~ ~~6.28%~~ ~~and monthly payments due through~~ ~~May 2015~~. ~~The second loan, effective as of~~ ~~June 25, 2009, was for~~ ~~€0.3 million, having an effective rate of~~ ~~4.57%~~ ~~and monthly payments due through~~ ~~November 2015. The fair value of both debts approximate their carrying values at~~ ~~December 31, 2011~~.

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~~Table of Contents~~

Future principal maturities of long-term debt as of December 31, ~~2011~~2012 are as follows:


Year ending December 31,	(in thousands)		(in thousands)
2012	$	1,617
2013	486		$	948
2014	300,000		396
2015	519		648
2016	—		—
2017			—
thereafter	145,000		845,000
	$	447,622	$	846,992

Interest expense on long-term debt was $~~22.1~~17.4 million, $~~24.9~~22.1 million and $~~26.7~~24.9 million for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, respectively.

In May 2006, we completed the offering of $300 million of 3.25% Senior Convertible Notes due in 2026 (2006 Notes) through an unconsolidated subsidiary, QIAGEN Euro Finance. The net proceeds of the 2006 Notes ~~were~~are loaned by Euro Finance to consolidated subsidiaries and at December 31, ~~2011~~2012 and ~~2010~~2011, $300 million is included in long-term debt for the loan amounts payable to Euro Finance. These long-term notes payable to Euro Finance have an effective interest rate of ~~3.97%~~3.7% and ~~are~~were originally due in December 2014. In 2012, we refinanced the $300 million note with QIAGEN Euro Finance and under the new terms the debt is due in May 2026. Interest is payable semi-annually in May and November. The 2006 Notes were issued at 100% of principal value, and are convertible into 15.0 million common shares at the option of the holders upon the occurrence of certain events, at a price of $20.00 per share, subject to adjustment. QIAGEN N.V. has an agreement with Euro Finance to issue shares to the investors in the event of conversion. This subscription right, along with the related receivable, is recorded at fair value in the equity of QIAGEN N.V. as paid-in capital. The 2006 Notes cannot be called for the first 7 years and are callable thereafter subject to a provisional call trigger of 130% of the conversion price. In addition, the holders of the 2006 Notes may require QIAGEN to repurchase all or a portion of the outstanding Notes for 100% of the principal amount, plus accrued interest, on May 16, 2013, 2017 and 2022. Based on an estimation using available over-the-counter market information on the convertible bond issued by QIAGEN Euro Finance, the fair value of the 2006 Notes at December 31, ~~2011~~2012 was $~~311.6~~358.4 million. We have reserved 15.0 million common shares for issuance in the event of conversion.

In August 2004, we completed the sale of $150 million of 1.5% Senior Convertible Notes due in 2024 (2004 Notes), through our unconsolidated subsidiary QIAGEN Finance. The net proceeds of the Senior Convertible Notes ~~were~~are loaned by QIAGEN Finance to consolidated subsidiaries ~~in the U.S. and Switzerland~~with an effective interest rate of 1.8% and at December 31, ~~2011~~2012 and ~~2010~~2011, $145 million is included in long-term debt for the loan amounts payable to QIAGEN Finance. ~~These long-term~~The notes ~~payable to QIAGEN Finance originally matured in~~ ~~July 2011. We refinanced the~~ ~~$145 million~~ ~~note, which was loaned under another agreement to another consolidated subsidiary, and is payable to QIAGEN Finance with an effective interest rate of~~ ~~1.84%~~ ~~and is~~are due in February ~~2024. This refinancing does not impact the amounts payable by QIAGEN Finance under the~~ ~~2004~~ ~~Notes.~~2024. Interest is payable semi-annually in February and August. The 2004 Notes were issued at 100% of principal value, and are convertible into 11.5 million common shares at the option of the holders upon the occurrence of certain events at a price of $12.6449 per share, subject to adjustment. QIAGEN N.V. has an agreement with QIAGEN Finance to issue shares to the

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investors in the event of conversion. This subscription right, along with the related receivable, is recorded at fair value in the equity of QIAGEN N.V. as paid-in capital. The 2004 Notes may be redeemed, in whole or in part, at QIAGEN’s option on or after August 18, 2011, at 100% of the principal amount, provided that the actual trading price of our common shares exceeds 120% of the conversion price for twenty consecutive trading days. In addition, the holders of the 2004 Notes may require QIAGEN to repurchase all or a portion of the outstanding 2004 Notes for 100% of the principal amount, plus accrued interest, on August 18, 2014 and 2019. Based on an estimation using available over-the-counter market information on the convertible bond issued by QIAGEN Finance, the fair value of the 2004 Notes at December 31, ~~2011~~2012 was $~~167.0~~209.7 million. We have reserved 11.5 million common shares for issuance in the event of conversion.


~~17.~~	~~Share-Based Compensation~~

16. Income Taxes

Income before provision for income taxes for the years ended December 31, 2012, 2011 and 2010 consisted of:



(in thousands)	2012		2011		2010
Pretax income in The Netherlands	$	27,222	$	30,232	$	55,431
Pretax income from foreign operations	117,931		65,980		117,690
	$	145,153	$	96,212	$	173,121

The provisions for income taxes for the years ended December 31, 2012, 2011 and 2010 are as follows:



(in thousands)	2012			2011			2010
Current—The Netherlands	$	3,271		$	6,752		$	12,265
—Foreign	35,112			26,372			36,487
	38,383			33,124			48,752
Deferred—The Netherlands	—			—			—
—Foreign	(22,767		)	(31,861		)	(19,942		)
	(22,767		)	(31,861		)	(19,942		)
Total provision for income taxes	$	15,616		$	1,263		$	28,810

The Netherlands statutory income tax rate for the years ended December 31, 2012, 2011 and 2010 was 25%, 25% and 25.5%. The principal items comprising the differences between income taxes computed at the Netherlands statutory rate and the effective tax rate for the years ended December 31, 2012, 2011 and 2010 are as follows:



	2012					2011					2010
(in thousands)	Amount			Percent		Amount			Percent		Amount			Percent
Income taxes at The Netherlands statutory rate	$	36,288		25.0	%	$	24,053		25.0	%	$	44,146		25.5	%
Earnings of subsidiaries taxed at different rates	5,180			3.6		3,204			3.3		7,710			4.5
Tax impact from permanent items	4,854			3.4		5,989			6.2		3,295			1.9
Tax impact from tax exempt income	(36,969		)	(25.5	)	(23,382		)	(24.3	)	(10,283		)	(6.0	)
Tax contingencies, net	2,729			1.9		(1,675		)	(1.7	)	(1,269		)	(0.7	)
Taxes due to changes in tax rates	(1,086		)	(0.8	)	(3,521		)	(3.7	)	(1,400		)	(0.8	)
Taxes due to changes in tax laws	2,697			1.9		—			—		—			—
Restructuring	—			—		—			—		(12,903		)	(7.5	)
Prior year taxes	2,805			1.9		(2,632		)	(2.7	)	476			0.3
Other items, net	(882		)	(0.6	)	(773		)	(0.8	)	(962		)	(0.6	)
Total provision for income taxes	$	15,616		10.8	%	$	1,263		1.3	%	$	28,810		16.6	%

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We conduct business globally and, as a result, file numerous consolidated and separate income tax returns in the Netherlands, Germany, Switzerland and the U.S. federal jurisdiction, as well as in various other state and foreign jurisdictions. In the normal course of business, we are subject to examination by taxing authorities throughout the world. Tax years in the Netherlands are open since 2000 for income tax examinations by tax authorities. Our subsidiaries, with few exceptions, are no longer subject to income tax examinations by tax authorities for years before 2008. The U.S. consolidated group is subject to federal and most state income tax examinations by tax authorities beginning the year ending December 31, 2008 through the current period.

During 2011, the tax authorities audited the income tax returns of our German subsidiaries for the tax years 2006 through 2009. The outcome of the audit resulted in a current tax liability of $5.3 million primarily related to the timing of certain deductions. As such, a deferred tax asset and deferred tax benefit was recorded that substantially offset the current year liability and expense. As a result of the audit being settled in 2011, the Company released $2.3 million of tax reserves through income tax expense.

We do not currently anticipate that our existing reserves related to uncertain tax positions as of December 31, 2012 will significantly increase or decrease during the twelve-month period ending December 31, 2013; however, various events could cause our current expectations to change in the future. The majority of these uncertain tax positions, if ever recognized in the financial statements, would be recorded in the statement of operations as part of the income tax provision.

Changes in the gross amount of unrecognized tax benefits are as follows:




(in thousands)	Unrecognized Tax Benefits
Balance at December 31, 2010	$	8,673
Additions based on tax positions related to the current year	757
Additions for tax positions of prior years	31
Settlements with taxing authorities	(2,257		)
Reductions due to lapse of statute of limitations	(207		)
Decrease from currency translation	(62		)
Balance at December 31, 2011	$	6,935
Additions based on tax positions related to the current year	819
Additions for tax positions of prior years	3,608
Reductions due to lapse of statute of limitations	(691		)
Increase from currency translation	104
Balance at December 31, 2012	$	10,775

At December 31, 2012 and 2011, our net unrecognized tax benefits totaled approximately $8.8 million and $6.3 million, respectively, of which $8.8 million and $6.3 million in benefits, if recognized, would favorably, affect our effective tax rate in any future period. It is possible that approximately $2.4 million of the unrecognized tax benefits may be released during the next 12 months due to lapse of statute of limitations or settlements with tax authorities.

Our policy is to recognize interest accrued related to unrecognized tax benefits in interest expense and penalties within tax provision expense. At December 31, 2012 and 2011, we have net interest expense and penalties of $2.8 million and $0.1 million, respectively. At December 31, 2012 and 2011, we have accrued interest of $3.0 million and $0.5 million, respectively, that are not included in the table above.

We have recorded net deferred tax liabilities of $165.0 million and $181.5 million at December 31, 2012 and 2011, respectively. The 2011 deferred taxes have been adjusted to correctly reflect as current or non-current and to net deferred tax positions within the same tax jurisdictions. These balance sheet reclassifications have no impact on retained earnings. The components of the net deferred tax liability at December 31, 2012 and December 31, 2011 are as follows:

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	2012						2011
(in thousands)	Deferred Tax Assets			Deferred Tax Liability			Deferred Tax Assets			Deferred Tax Liability
Net operating loss carry forwards	$	17,664		$	—		$	10,389		$	—
Accrued and other liabilities	21,412			(552		)	25,981			(65		)
Inventories	2,991			(1,410		)	3,106			(1,578		)
Allowance for bad debts	687			(600		)	726			(471		)
Currency revaluation	266			(746		)	—			(546		)
Depreciation and amortization	606			(10,027		)	124			(19,854		)
Capital lease	2,149			—			2,392			—
Tax credits	611			—			6,848			—
Unremitted profits and earnings	—			(1,215		)	—			(1,175		)
Intangibles	5,270			(220,880		)	2,523			(218,027		)
Equity awards	10,082			—			7,289			—
Other	10,460			(1,314		)	6,553			(1,432		)
Valuation allowance	(442		)	—			(4,260		)	—
	$	71,756		$	(236,744	)	$	61,671		$	(243,148	)
Net deferred tax liabilities				$	(164,988	)				$	(181,477	)

At December 31, 2012 and 2011, we had $58.7 million and $39.4 million in total foreign net operating losses. At December 31, 2012 and 2011, we had $13.5 million and $5.1 million of U.S. federal net operating loss (NOL) carryforwards. At December 31, 2012, the entire NOLs in the U.S. are subject to limitations under Section 382 of the Internal Revenue Code but all losses subject to IRC 382 limitation are expected to be utilized before they expire. The net operating losses in the U.S. will expire beginning December 31, 2021 through December 31, 2031. As of December 31, 2012 and 2011, we had other foreign NOL carryforwards totaling approximately $45.2 million and $34.3 million, respectively. These NOLs were primarily generated from acquisitions and operating losses from our subsidiaries. A portion of the foreign net operating losses will be expiring beginning December 31, 2013. The valuation allowance amounts for the years ended December 31, 2012 and 2011 are $0.4 million and $4.3 million, respectively. We had a release of the valuation allowance of $3.9 million in 2012 as an adjustment to goodwill related to a deferred tax asset from a 2009 acquisition. In 2011, we had a decrease of valuation allowance of $1.1 million from the deferred tax assets that were used to offset current tax liability.

As of December 31, 2012, a provision has not been made for residual Netherlands income taxes on the undistributed earnings of the majority of our foreign subsidiaries as these earnings are considered to be either permanently reinvested or can be repatriated tax free. These earnings retained by subsidiaries and equity accounted investments amounted to $185.0 million at December 31, 2012. We have $18.0 million of undistributed earnings that we do not consider permanently reinvested and have recorded deferred income taxes or withholding taxes at December 31, 2012 and December 31, 2011, of approximately $1.2 million. There are no income tax consequences regarding payment of dividends to our shareholders. To date, we have never paid dividends.

17. Accumulated Other Comprehensive Income

The following table is a summary of the components of accumulated other comprehensive income at December 31:



(in thousands)	2012			2011
Net unrealized loss on hedging contracts, net of tax of $0.1 million in 2011	$	—		$	(762	)
Net unrealized (loss) gain on pension, net of tax	(483		)	115
Foreign currency effects from intercompany long-term investment transactions, net of tax of $4.4 million and $4.9 million in 2012 and 2011, respectively	5,954			7,369
Foreign currency translation adjustments	38,520			9,182
Accumulated other comprehensive income	$	43,991		$	15,904

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18. Share Repurchase Program

In 2012, the Supervisory Board approved a program authorizing management to purchase up to a total of $100 million of our common shares (excluding transaction costs). Through December 31, 2012, a total of 1.9 million QIAGEN shares were repurchased for approximately $35.7 million, in total. We intend to complete the share repurchase program in 2013. The cost of repurchased shares is included in treasury stock and reported as a reduction in total equity when a repurchase occurs. Repurchased shares will be held in treasury in order to satisfy various obligations, which include exchangeable debt instruments and employee share-based remuneration plans.

19. Earnings per Common Share



	Years ended December 31,
(in thousands, except per share data)	2012		2011		2010
Net income attributable to the owners of QIAGEN N.V.	$	129,506	$	96,038	$	144,311

Weighted average number of common shares used to compute basic net income per common share	235,582		233,850		232,635
Dilutive effect of stock options and restrictive stock units	2,341		2,876		2,843
Dilutive effect of outstanding warrant shares	2,823		2,338		5,005
Weighted average number of common shares used to compute diluted net income per common share	240,746		239,064		240,483
Outstanding options and awards having no dilutive effect, not included in above calculation	2,906		3,995		2,152
Outstanding warrants having no dilutive effect, not included in above calculation	23,644		23,591		21,462

Basic earnings per common share attributable to the owners of QIAGEN N.V.	$	0.55	$	0.41	$	0.62
Diluted earnings per common share attributable to the owners of QIAGEN N.V.	$	0.54	$	0.40	$	0.60

20. Commitments and Contingencies

Lease Commitments

We lease facilities and equipment under operating lease arrangements expiring in various years through 2022. Certain rental commitments provide for escalating rental payments or have renewal options extending through various years. Certain facility and equipment leases constitute capital leases expiring in various years through 2018. The accompanying consolidated financial statements include the assets and liabilities arising from these capital lease obligations. Rent expense under operating lease agreements was $21.5 million, $20.3 million and $17.9 million for the years ended December 31, 2012, 2011 and 2010, respectively.

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Minimum future obligations under capital and operating leases at December 31, 2012 are as follows:



(in thousands)	Capital Leases			Operating Leases
2013	$	5,396		$	16,309
2014	5,304			11,389
2015	5,290			9,834
2016	3,998			5,879
2017	1,429			3,234
Thereafter	1,429			7,809
	22,846			$	54,454
Less: Amount representing interest	(2,958		)
	19,888
Less: Current portion	(4,203		)
Long-term portion	$	15,685

Licensing and Purchase Commitments

We have licensing agreements with companies, universities and individuals, some of which require certain up-front payments. Royalty payments are required on net product sales ranging from one to 25 percent of covered products or based on quantities sold. Several of these agreements have minimum royalty requirements. The accompanying consolidated financial statements include accrued royalties relating to these agreements in the amount of $17.6 million and $25.7 million at December 31, 2012 and 2011, respectively. Royalty expense relating to these agreements amounted to $52.5 million, $43.3 million, and $45.7 million for the years ended December 31, 2012, 2011 and 2010, respectively. Royalty expense is primarily recorded in cost of sales, with a small portion recorded as research and development expense depending on the use of the technology under license. Some of these agreements also have minimum raw material purchase requirements and requirements to perform specific types of research.

At December 31, 2012, we had commitments to purchase goods or services, and for future minimum guaranteed royalties. They are as follows:



(in thousands)	Purchase Commitments		License & Royalty Commitments
2013	$	54,754	$	9,224
2014	4,124		3,762
2015	1,339		1,773
2016	152		1,798
2017	—		1,799
Thereafter	—		2,905
	$	60,369	$	21,261

Contingent Consideration Commitments

Pursuant to the purchase agreements for certain acquisitions, as discussed more fully in Note 5, we could be required to make additional contingent cash payments totaling up to $134.2 million based on the achievement of certain revenue and operating results milestones as follows: $18.9 million in 2013, $23.4 million in 2014, $16.3 million in 2015, $17.5 million in 2016, $7.0 million in 2017, and $51.1 million, payable in any 12-month period from now until 2017 based on the accomplishment of certain revenue targets, the launch of certain products or the grant of certain patent rights. Of the $134.2 million total contingent obligation, we have assessed the fair value at December 31, 2012, to be $19.0 million, where $9.8 million and $9.2 million are included in accrued and other liabilities and other long-term liabilities, respectively.

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Employment Agreements

Certain of our employment contracts contain provisions which guarantee the payments of certain amounts in the event of a change in control, as defined in the agreements, or if the executive is terminated for reasons other than cause, as defined in the agreements. At December 31, 2012, the commitment under these agreements totaled $15.3 million.

Contingencies

In the ordinary course of business, we provide a warranty to customers that our products are free of defects and will conform to published specifications. Generally, the applicable product warranty period is one year from the date of delivery of the product to the customer or of site acceptance, if required. Additionally, we typically provide limited warranties with respect to our services. From time to time, we also make other warranties to customers, including warranties that our products are manufactured in accordance with applicable laws and not in violation of third-party rights. We provide for estimated warranty costs at the time of the product sale. We believe our warranty reserves as of December 31, 2012 and 2011 appropriately reflect the estimated cost of such warranty obligations.

Preacquistion Contingencies

In connection with certain acquisitions, amounts were paid into escrow accounts to cover preacquistion contingencies assumed in the acquisition. The escrow amounts expected to be claimed by QIAGEN are recorded as an asset in prepaid and other expenses and amount to $7.5 million and $7.0 million as of December 31, 2012 and 2011, respectively. In addition, we have recorded $5.5 million and $6.2 million for preacquistion contingencies as a liability under accrued and other liabilities as of December 31, 2012 and 2011, respectively.

Litigation

From time to time, we may be party to legal proceedings incidental to our business. As of December 31, 2012, certain claims, suits or legal proceedings arising out of the normal course of business have been filed or were pending against QIAGEN or its subsidiaries. These matters have arisen in the ordinary course and conduct of business, as well as through acquisition. Although it is not possible to predict the outcome of such litigation, we assess the degree of probability and evaluate the reasonably possible losses that we could incur as a result of these matters. We accrue for any estimated loss when it is probable that a liability has been incurred and that the amount of the probable loss can be estimated. Based on the facts known to QIAGEN and after consultation with legal counsel, management believes that such litigation will not have a material adverse effect on QIAGEN’s financial position or results of operations.

21. Share-Based Compensation

We adopted the QIAGEN N.V. Amended and Restated 2005 Stock Plan (the Plan) in 2005. The Plan allows for the granting of stock rights and incentive stock options, as well as non-qualified options, stock grants and stock-based awards, generally with terms of up to 10 years, subject to earlier termination in certain situations. Generally, options vest over a three-year period. The vesting and exercisability of certain stock rights will be accelerated in the event of a Change of Control, as defined in the Plan. To date, all option grants have been at the market value on the grant date or at a premium above the closing market price on the grant date. We issue new Common Shares to satisfy option exercises and had approximately ~~22.1~~19.8 million

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Common Shares reserved and available for issuance under this plan at December 31, ~~2011~~2012.

In connection with the 2007 acquisition of Digene Corporation, we assumed three additional equity incentive plans. No new grants will be made under these plans. We had approximately 0.1 million common shares reserved and available for issuance under these plans at December 31, ~~2011~~2012.

Stock Options

During the years ended December 31, ~~2011~~2012 and ~~2010~~2011, we granted ~~601,897~~592,829 and ~~570,282~~601,897 stock options, respectively. The following are the weighted-average assumptions used in valuing the stock options granted to employees for the years ended December 31, 2012, 2011 ~~2011, 2010~~ and ~~2009:~~2010:

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	2011		2010		2009		2012		2011		2010
Stock price volatility	34	%	31	%	40	%	34	%	34	%	31	%
Risk-free interest rate	1.88	%	2.12	%	2.13	%	0.82	%	1.88	%	2.12	%
Expected life (in years)	4.97		4.84		5.01		4.89		4.97		4.84
Dividend rate	0	%	0	%	0	%	0	%	0	%	0	%
Forfeiture rate	6.1	%	7.0	%	7.7	%	5.9	%	6.1	%	7.0	%

A summary of the status of employee stock options as of December 31, ~~2011~~2012 and changes during the year then ended is presented below:


All Employee Options	Number of Shares (in thousands)		Weighted Average Exercise Price		Weighted Average Contractual Term	Aggregate Intrinsic Value (in thousands)		Number of Shares (in thousands)		Weighted Average Exercise Price		Weighted Average Contractual Term	Aggregate Intrinsic Value (in thousands)
Outstanding at January 1, 2011	7,332		$	13.86
Outstanding at January 1, 2012								6,527		$	13.61
Granted	602		$	19.86				593		$	16.00
Exercised	(655	)	$	12.95				(1,444	)	$	11.53
Forfeited	(62	)	$	19.56				(82	)	$	18.90
Expired	(690	)	$	21.79				(261	)	$	17.64
Outstanding at December 31, 2011	6,527		$	13.61	3.65	$	15,315
Exercisable at December 31, 2011	5,453		$	12.37	2.66	$	15,315
Vested and expected to vest at December 31, 2011	6,436		$	13.53	3.57	$	15,315
Outstanding at December 31, 2012								5,333		$	14.16	4.09	$	25,006
Exercisable at December 31, 2012								4,252		$	13.18	2.91	$	23,664
Vested and expected to vest at December 31, 2012								5,257		$	14.12	4.01	$	24,886

Generally, stock option grants are valued as a single award with a single average expected term and are amortized over the vesting period. The weighted-average grant-date fair value of options granted during the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010 was $~~6.49~~4.80, $~~6.42~~6.49 and $~~6.33~~6.42, respectively. The total intrinsic value of options exercised during the years ended December 31, ~~2011~~2012 and ~~2010~~2011 was $~~3.7~~7.2 million and $~~7.7~~3.7 million, respectively. At December 31, ~~2011~~2012, the unrecognized share-based compensation expense related to employee stock option awards including estimated forfeitures is approximately $~~4.0~~3.5 million and will be recognized over a weighted average period of approximately ~~1.73~~1.66 years.

At December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, options were exercisable with respect to ~~5.5~~4.3 million, ~~6.4~~5.5 million and ~~7.4~~6.4 million Common Shares at a weighted average price of $~~12.37~~13.18, $~~12.93~~12.37 and $~~14.36~~12.93 per share, respectively. The options outstanding at December 31, ~~2011~~2012 expire in various years through ~~2021~~2022.

~~Restricted~~ Stock Units

~~Restricted stock~~Stock units represent rights to receive Common Shares at a future ~~date.~~date and include restricted stock units which are subject to time-vesting only and performance stock units which include performance conditions in addition to time-vesting. There is no exercise price and the fair market value at the time of the grant is recognized ~~ratably~~ over the requisite vesting period, generally 10 years. The fair market value is determined based on the number of restricted stock units granted and the market value of our shares on the grant date. Pre-vesting forfeitures were estimated to be approximately ~~7.7%~~7.1%. At December 31, ~~2011~~2012, there was $~~61.1~~67.6 million remaining in unrecognized compensation cost including estimated forfeitures related to these awards, which is expected to be recognized over a weighted average period of ~~8.0~~2.9 years. The weighted average grant date fair value of ~~restricted~~ stock units granted during the year ended December 31, ~~2011~~2012 was $~~19.82~~15.80. The total fair value of ~~restricted~~ stock units ~~released~~that vested during the years endedDecember 31, 2012 and 2011 was $13.3 million and $8.8 million, respectively.

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~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~was~~ ~~$8.8 million~~ ~~and~~ ~~$2.5 million, respectively.~~

A summary of ~~restricted~~ stock units as of December 31, ~~2011~~2012 and changes during the year are presented below:

Restricted Stock Units
Restricted Stock
Units (in thousands)

Weighted
Average
Contractual
Term

Aggregate
Intrinsic
Value
(in thousands)
Outstanding at January 1, 2011 4,417

Granted 1,929

Vested (451 )
Forfeited (244 )
Outstanding at December 31, 2011 5,651
2.91
$ 78,030
Vested and expected to vest at December 31, 2011 4,597
2.78
$ 63,488



Stock Units	Stock Units (in thousands)		Weighted Average Contractual Term	Aggregate Intrinsic Value (in thousands)
Outstanding at January 1, 2012	5,651
Granted	2,574
Vested	(831	)
Forfeited	(473	)
Outstanding at December 31, 2012	6,921		2.85	$	125,602
Vested and expected to vest at December 31, 2012	5,732		2.74	$	104,029

Compensation Expense

Share-based compensation expense before taxes for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010 totaled approximately $~~19.5~~25.4 million, $~~13.6~~19.5 million and $~~9.7~~13.6 million, respectively, as shown in the table below. No share-based compensation cost was capitalized in inventory in ~~2011~~2012, ~~2010~~2011 or ~~2009~~2010 as the amounts were not material. The excess tax benefit realized for the tax deductions of the share-based payment arrangements totaled $~~4.2~~1.5 million, $~~2.0~~4.2 million and $~~5.9~~2.0 million, respectively, for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010.


Compensation Expense (in thousands)	2011		2010		2009		2012		2011		2010
Cost of sales	$	1,672	$	932	$	799	$	2,328	$	1,672	$	932
Research and development	3,055		2,087		1,826		4,167		3,055		2,087
Sales and marketing	4,285		2,885		1,936		6,123		4,285		2,885
General and administrative	10,528		7,688		5,186		12,737		10,528		7,688
Share-based compensation expense before taxes	19,540		13,592		9,747
Income tax benefit	4,231		2,856		2,913
Net share-based compensation expense	$	15,309	$	10,736	$	6,834
Share-based compensation expense							$	25,355	$	19,540	$	13,592


~~18.~~	~~Commitments and Contingencies~~

~~Lease Commitments~~22. Employee Benefits

We lease facilities and equipment under operating lease arrangements expiring in various years through an indefinite period of time. Certain rental commitments provide for escalating rental payments or have renewal options extending through various years. Certain facility and equipment leases constitute capital leases expiring in various years through ~~2018. The accompanying consolidated financial statements include the assets and liabilities arising from these capital lease obligations. Rent expense under operating lease agreements was~~ ~~$20.3 million~~, ~~$17.9 million~~ ~~and~~ ~~$13.0 million~~ ~~for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009, respectively.~~

~~Minimum future obligations under capital and operating leases at~~ ~~December 31, 2011~~ ~~are as follows:~~

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(in thousands)
Capital
Leases

Operating
Leases
2012 $ 5,384
$ 15,879
2013 5,307
12,067
2014 5,196
9,316
2015 5,178
6,905
2016 3,922
4,763
Thereafter 2,802
3,018
27,789
$ 51,948
Less: Amount representing interest (4,287 )
23,502

Less: Current portion (4,006 )
Long-term portion $ 19,496

~~Licensing and Purchase Commitments~~

~~We have licensing agreements with companies, universities and individuals, some of which require certain up-front payments. Royalty payments are required on net product sales ranging from~~ ~~one~~ to ~~25 percent~~ of covered products or based on quantities sold. Several of these agreements have minimum royalty requirements. The accompanying consolidated financial statements include accrued royalties relating to these agreements in the amount of ~~$25.7 million~~ ~~and~~ ~~$16.4 million~~ at ~~December 31, 2011~~ ~~and~~ ~~2010, respectively. Royalty expense relating to these agreements amounted to~~ ~~$43.3 million~~, ~~$45.7 million, and~~ ~~$47.2 million~~ ~~for the years ended~~ ~~December 31, 2011~~, ~~2010~~ ~~and~~ ~~2009~~, respectively. Royalty expense is primarily recorded in cost of sales, with a small portion recorded as research and development expense depending on the use of the technology under license. Some of these agreements also have minimum raw material purchase requirements and requirements to perform specific types of research.

At ~~December 31, 2011, we had commitments to purchase goods or services, and for future minimum guaranteed royalties. They are as follows:~~

(in thousands)
Purchase
Commitments

License & Royalty
Commitments
2012 $ 54,686
$ 1,600
2013 25,556
1,122
2014 496
1,222
2015 —
1,222
2016 —
1,222
Thereafter —
3,388
$ 80,738
$ 9,776

~~Contingent Consideration Commitments~~

~~Pursuant to the purchase agreements for certain acquisitions, as discussed more fully in Note 4, we could be required to make additional contingent cash payments totaling up to~~ ~~$103.1 million~~ ~~based on the achievement of certain revenue and operating results milestones as follows:~~ ~~$26.5 million~~ in ~~2012~~, ~~$11.1 million~~ in ~~2013~~, ~~$12.3 million~~ in ~~2014~~, ~~$4.7 million~~ in ~~2015~~, ~~$6.4 million~~ in ~~2016, and~~ ~~$42.1 million, payable in any 12-month period from now until~~ ~~2016~~ ~~based on the accomplishment of certain revenue targets, the launch of certain products or the grant of certain patent rights. Of the~~ ~~$103.1 million~~ ~~total contingent obligation, approximately~~ ~~$39.8 million~~ ~~is accrued as of~~ ~~December 31, 2011. We reassessed the fair value of the contingent consideration as of~~ ~~December 31, 2011~~ ~~the result of which was not materially different from the fair value determined as of the date of the acquisitions.~~

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~~Table of Contents~~

~~Employment Agreements~~

Certain of our employment contracts contain provisions which guarantee the payments of certain amounts in the event of a change in control, as defined in the agreements, or if the executive is terminated for reasons other than cause, as defined in the agreements. At ~~December 31, 2011, the commitment under these agreements totaled~~ ~~$19.2 million~~.

~~Contingencies~~

In the ordinary course of business, we provide a warranty to customers that our products are free of defects and will conform to published specifications. Generally, the applicable product warranty period is one year from the date of delivery of the product to the customer or of site acceptance, if required. Additionally, we typically provide limited warranties with respect to our services. From time to time, we also make other warranties to customers, including warranties that our products are manufactured in accordance with applicable laws and not in violation of third-party rights. We provide for estimated warranty costs at the time of the product sale. We believe our warranty reserves as of ~~December 31, 2011~~ ~~and~~ ~~2010~~ ~~appropriately reflect the estimated cost of such warranty obligations.~~

~~Preacquistion Contingencies~~

In connection with certain acquisitions, amounts were paid into escrow accounts to cover preacquistion contingencies assumed in the acquisition. The escrow amounts expected to be claimed by QIAGEN are recorded as an asset in prepaid and other expenses and amount to ~~$7.0 million~~ ~~as of~~ ~~December 31, 2011~~ (~~$27.0 million~~ ~~as of~~ ~~December 31, 2010). In addition, we have recorded~~ ~~$6.2 million~~ ~~for preacquistion contingencies as a liability under accrued and other liabilities as of~~ ~~December 31, 2011~~ (~~$28.7 million~~ ~~as of~~ ~~December 31, 2010~~).

~~Litigation~~

~~From time to time, QIAGEN may be party to legal proceedings incidental to its business. As of~~ ~~December 31, 2011~~, certain claims, suits or legal proceedings arising out of the normal course of business have been filed or were pending against QIAGEN or its subsidiaries. These matters have arisen in the ordinary course and conduct of business, as well as through acquisition. Although it is not possible to predict the outcome of such litigation, based on the facts known to QIAGEN and after consultation with legal counsel, management believes that such litigation will not have a material adverse effect on QIAGEN’s financial position or results of operations.

~~QIAGEN Sciences, Inc. v. Operon Biotechnologies, Inc.~~

On ~~July 2, 2009~~, Operon Biotechnologies, Inc. (Operon) commenced arbitration against QIAGEN Sciences, Inc. asserting a breach of a supply agreement between the parties and seeking monetary damages. Operon asserted that QIAGEN failed to comply with the preferred supplier provisions of the agreement and that this breach caused damages, including lost profits. QIAGEN denied the allegations and asserted counterclaims. The dispute was submitted to an arbitration panel and in ~~June 2011~~ ~~the arbitration panel concluded in favor of QIAGEN on all claims. As a result, in 2011, Operon paid QIAGEN approximately~~ ~~$2.1 million~~ ~~for past-due receivables, interest and legal fees.~~

~~Cybeles Life Science Consulting (Claimant) vs. Research Biolabs Ptd. Ltd. (Respondent)~~

On August 18, 2010, Cybeles Life Science Consulting (Cybeles) initiated an arbitration proceeding against QIAGEN's Singaporean affiliate Research Biolabs Pte. Ltd. (Research Biolabs) in the Swiss Chambers' Court of Arbitration and Mediation. The Notice of Arbitration alleged breaches of the distribution agreement between the parties, and claimed loss and damage in the amount of approximately ~~$1.3 million. Research Biolabs considers the complaint as not justified and will continue to vigorously defend the claim.~~


~~19.~~	~~Employee Benefit Plans~~

We maintain various benefit plans, including defined contribution and defined benefit plans. Our U.S. defined contribution plan is qualified under Section 401(k) of the Internal Revenue Code, and covers substantially all U.S. employees. Participants may contribute a portion of their compensation not exceeding a limit set annually by the Internal Revenue Service. This plan includes a provision for us to match a portion of employee contributions. Total expense under the 401(k) plans, including the plans acquired via business acquisitions, was $~~2.3~~3.1 million, $~~2.1~~2.3 million and $~~2.0~~2.1 million for the years ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010, respectively. We also have a defined contribution plan which covers certain executives. We make matching contributions up to an established maximum. Matching contributions made to the plan, and expensed, totaled approximately $0.3 million in each year ended December 31, ~~2011~~2012, ~~2010~~2011 and ~~2009~~2010.

~~F-37~~

~~Table of Contents~~

We have four defined benefit, non-contributory retirement or termination plans that cover certain employees in Germany, France, Japan and Italy. These defined benefit plans provide benefits to covered individuals satisfying certain age and service requirements. For certain plans, we calculate the vested benefits to which employees are entitled if they separate immediately. The benefits accrued on a pro-rata basis during the employees’ employment period are based on the individuals’ salaries, adjusted for inflation. The liability under the defined benefit plans was $4.0 million at December 31, 2012 and $2.9 million at December 31, 2011 ~~and~~ ~~$2.4 million~~ at ~~December 31, 2010~~, and is included as a component of other long-term liabilities on the consolidated balance sheets.


~~20.~~	~~Related Party Transactions~~

23. Related Party Transactions

We have a 100% interest in QIAGEN Finance (Luxembourg) S.A. (QIAGEN Finance) and QIAGEN Euro Finance (Luxembourg) S.A. (Euro Finance), which were established for the purpose of issuing convertible debt. As discussed in Note 10, QIAGEN Finance and Euro Finance are variable interest entities for which we do not hold any variable interests and are not the primary beneficiary, thus they are not consolidated. Accordingly, the convertible debt is not included in the consolidated statements of QIAGEN N.V., though QIAGEN N.V. does report the full obligation of the debt through its liabilities to QIAGEN Finance and Euro Finance. As of December 31, 2012 and 2011, we had loans payable to QIAGEN Finance of $145.0 million and accrued interest due to QIAGEN Finance of $4.4 million. We also had amounts receivable from QIAGEN Finance of $3.4 million. As of December 31, 2012 and 2011, we have a loan payable to Euro Finance of $300.0 million, accrued interest due to Euro Finance of $2.6 million and $3.0 million, respectively and amounts receivable from Euro Finance of $1.3 million and $1.6

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Table of Contents

million, respectively. The amounts receivable are related to subscription rights which are recorded net in the equity of QIAGEN N.V. as paid-in capital.

In 2011 ~~and 2010,~~, we had a consulting agreement with Dr. Metin Colpan, our former Chief Executive Officer and current Supervisory Board member, pursuant to which Dr. Colpan is paid a fee of EUR 2,750 per day for consulting services, subject to adjustment. We incurred consulting expenses of approximately $0.1 million ~~and~~ ~~$0.3 million~~ inas of December 31, 2011 ~~and~~ ~~2010, respectively,~~ for scientific consulting services under this agreement. In January 2012, the agreement under which Dr. Colpan provided scientific consulting services terminated.

~~We have~~During 2012 we entered into a ~~100%~~ ~~interest~~development and license agreement with a company in ~~QIAGEN Finance (Luxembourg) S.A. (QIAGEN Finance) and QIAGEN Euro Finance (Luxembourg) S.A. (Euro Finance),~~ which ~~were established for~~we also hold an interest. Under the ~~purpose~~terms of issuing convertible debt. As discussed in Note 12, QIAGEN Finance and Euro Finance are variable interest entities with no primary beneficiary, thus they are not consolidated. Accordingly, the convertible debt is not included in the consolidated statements of QIAGEN N.V., though QIAGEN N.V. does report the full obligation of the debt through its liabilities to QIAGEN Finance and Euro Finance. Asthis agreement we will pay a total of ~~December 31, 2011~~$7.7 million in 2013 and ~~2010, we had loans payable to QIAGEN Finance of~~another $~~145.0~~2.0 million ~~and accrued interest due to QIAGEN Finance~~in total based on the achievement of ~~$4.4 million~~ ~~and~~ ~~$3.3 million, respectively. We also had amounts receivable from QIAGEN Finance of~~ ~~$3.4 million~~ ~~and~~ ~~$2.3 million, respectively. As of~~ ~~December 31, 2011~~ ~~and~~ ~~2010, we have a loan payable to Euro Finance of~~ ~~$300.0 million, accrued interest due to Euro Finance of~~ ~~$3.0 million~~ ~~and amounts receivable from Euro Finance of~~ ~~$1.6 million. The amounts receivable are related to subscription rights which are recorded net in the equity of QIAGEN N.V. as paid-in capital.~~certain milestones.

From time to time, we have transactions with other companies in which we hold an interest all of which are individually and in the aggregate immaterial, as summarized in the table below.


Year ending December 31, (in thousands)	2011		2010		2012		2011
Net sales	$	6,287	$	2,605	$	7,068	$	6,287
Loans receivable	$	1,539	$	1,560
Accounts receivable	$	3,606	$	2,400	$	2,651	$	3,606
Accounts payable	$	4,642	$	1,755	$	3,699	$	4,642
Loans receivable					$	1,674	$	1,539


~~21.~~	~~Segment Information~~

~~Considering the acquisitions made during 2011, we determined that we still operate as one business segment in accordance with ASC Topic 280,~~ ~~Segment Reporting~~. As a result of our continued restructuring and streamlining of the growing organization, and with revised internal budgeting and reporting approaches, our chief operating decision maker (CODM) makes decisions with regards to business operations and resource allocation based on evaluations of QIAGEN as a whole. Accordingly, we operate as one business segment. Summarized product category and geographic information is shown in the tables below.

~~Product Category Information~~

~~Net sales for the product categories are attributed based on those revenues related to sample and assay products and similarly related revenues, and revenues derived from instrumentation sales.~~24. Subsequent Event

(in thousands) 2011 2010 2009
Net Sales
Consumables and Related Revenues $ 1,011,863
$ 937,714
$ 870,216
Instrumentation 157,884
149,717
139,609
Total $ 1,169,747
$ 1,087,431
$ 1,009,825

~~F-38~~

~~Table~~Since December 31, 2012 and through February 22, 2013, we have repurchased 1.9 million shares of ~~Contents~~

~~Geographical Information~~

~~Net sales are attributed to countries based on~~common shares under the ~~location of the subsidiary generating the sale. QIAGEN operates manufacturing facilities~~share repurchase program discussed more fully in Germany, Switzerland, China, the United Kingdom, France and the United States that supply products to other countries. The sales from these manufacturing operations to other countries are included in the Net Sales of the countries in which the manufacturing locations are based. The intersegment portions of such net sales are excluded to derive consolidated net sales. No single customer represents more than ten percent of consolidated net sales. Our official country of domicile is the Netherlands, which reported net sales ofNote 18, for approximately $~~23.9~~38.5 million, ~~$21.5 million~~ ~~and~~ ~~$20.3 million~~ ~~for the years ended~~ ~~2011~~, ~~2010~~ ~~and~~ ~~2009, respectively, and these amounts are included~~ in ~~the line item Europe as shown in the table below.~~total.

(in thousands) 2011 2010 2009
Net Sales
Americas:
United States $ 466,502
$ 472,682
$ 446,151
Other Americas 55,137
50,912
47,995
Total Americas 521,639
523,594
494,146
Europe 444,441
398,029
363,949
Asia Pacific & Rest of World 203,667
165,808
151,730
Total $ 1,169,747
$ 1,087,431
$ 1,009,825

~~Long-lived assets include property, plant and equipment. The Netherlands, which is included in the balances for Europe, reported long-lived assets of~~ ~~$1.1 million~~ ~~and~~ ~~$0.5 million~~ ~~for the years ended~~ ~~2011~~ ~~and~~ ~~2010, respectively.~~

(in thousands) 2011 2010
Long-lived assets
Americas:
United States $ 98,717
$ 100,342
Other Americas 2,579
2,154
Total Americas 101,296
102,496
Europe 259,220
231,405
Asia Pacific & Rest of World 11,276
11,763
Total $ 371,792
$ 345,664

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Table of Contents

SCHEDULE II

QIAGEN N.V. AND SUBSIDIARIES

SCHEDULE II—VALUATION AND QUALIFYING ACCOUNTS

FOR THE YEARS ENDED DECEMBER 31, 2012, 2011 ~~2010~~ AND ~~2009~~2010


(in thousands)	Balance at Beginning of Year		Provision Charged to Expense		Write-Offs			Foreign Exchange and Other			Balance at End of Year		Balance at Beginning of Year		Provision Charged to Expense		Write-Offs			Foreign Exchange and Other			Balance at End of Year
Year Ended December 31, 2009:
Allowance for doubtful accounts	$	3,070	$	1,705	$	(562	)	$	(811	)	$	3,402
Year Ended December 31, 2010:
Allowance for doubtful accounts	$	3,402	$	1,444	$	(771	)	$	(848	)	$	3,227	$	3,402	$	1,444	$	(771	)	$	(848	)	$	3,227
Year Ended December 31, 2011:
Allowance for doubtful accounts	$	3,227	$	2,131	$	(593	)	$	(450	)	$	4,315	$	3,227	$	2,131	$	(593	)	$	(450	)	$	4,315
Year Ended December 31, 2012:
Allowance for doubtful accounts													$	4,315	$	1,048	$	(240	)	$	98		$	5,221

S-1



(in thousands)	DxS Acquisition			SABiosciences Acquisition			Total
Purchase Price:
Cash consideration paid	$	94,823		$	97,586		$	192,409
Fair value of milestones	17,599			—			17,599
	$	112,422		$	97,586		$	210,008
Final Allocation:
Working capital	$	263		$	10,503		$	10,766
Fixed and other long-term assets	2,199			2,215			4,414
Product technology and know how	16,400			26,400			42,800
Purchased in-process research and development	1,400			1,700			3,100
Customer relationships	54,900			8,400			63,300
Tradename	4,100			1,900			6,000
Goodwill	55,417			62,433			117,850
Deferred tax liability on fair value of identifiable intangible assets acquired	(21,522		)	(15,965		)	(37,487		)
Liabilities assumed	(735		)	—			(735		)
	$	112,422		$	97,586		$	210,008



(in thousands)	December 31, 2011		December 31, 2010
$500 million note payable bearing interest at LIBOR plus a variable margin, repaid in 2011	$	—	$	425,000
Notes payable to QIAGEN Euro Finance bearing interest at an effective rate of 3.97% due in December 2014	300,000		300,000
Notes payable to QIAGEN Finance bearing interest at an effective rate of 1.84% due in February 2024	145,000		145,000
R&D-related loan bearing interest at 3.50% due in 2013	2,103		3,006
Production-related loans bearing interest at an effective rates of 4.57% and 6.28% due in May and November 2015	519		—
Total long-term debt	447,622		873,006
Less current portion	1,617		75,835
Long-term portion	$	446,005	$	797,171



Restricted Stock Units	Restricted Stock Units (in thousands)		Weighted Average Contractual Term	Aggregate Intrinsic Value (in thousands)
Outstanding at January 1, 2011	4,417
Granted	1,929
Vested	(451	)
Forfeited	(244	)
Outstanding at December 31, 2011	5,651		2.91	$	78,030
Vested and expected to vest at December 31, 2011	4,597		2.78	$	63,488