UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington D.C. 20549

FORM 20-F

o	REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended June 30, ~~2009~~

2010

TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from __________ to __________

o	SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Date of event requiring this shell company report .................

Commission file number 000-49843

PRANA BIOTECHNOLOGY LIMITED

(Exact name of Registrant as specified in its charter

and translation of Registrant’s name into English)

Australia

(Jurisdiction of incorporation or organization)

Level 2, 369 Royal Parade, Parkville, Victoria 3052, Australia

(Address of principal executive offices)

Geoffrey Kempler, Chief Executive Officer

Level 2, 369 Royal Parade, Parkville, Victoria 3052, Australia

+61 3 9349 4906 (phone) ; +61 3 9348 0377 (fax)

(Name, telephone, e-mail and/or facsimile number and address of company contact person)

Securities registered or to be registered pursuant to Section 12(b) of the Act:






Title of each class	Name of each exchange on which registered
American Depositary Shares,	~~NASDAQ Capital Market~~
each representing ten Ordinary Shares	NASDAQ Capital Market

Securities registered or to be registered pursuant to Section 12(g) of the Act:None

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act:None

Indicate the number of outstanding shares of each of the issuer’s classes of capital or common stock as of the close of the period covered by the annual report:

Ordinary Shares, as of June 30, ~~2009.....................202,710,473~~2010 234,045,871

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.

YesoNox

If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.

YesoNox

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

YesxNoo

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

Yeso Noo No x

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act. (Check one):






~~Large accelerated filer~~o	~~Accelerated filer~~o	~~Non-accelerated filer~~x

Large accelerated filer o Accelerated filer o Non-accelerated filer x

Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:






U.S. GAAPo	International Financial	~~Other~~o
	Reporting Standards as issued by
	the International Accounting
	Standards Boardx	Other o

If “Other” has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow:

Item 17o Item 18o

If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

YesoNox

This Annual Report on Form 20-F is incorporated by reference into our Registration Statement on Form S-8 (File No. 333-153669).

INTRODUCTION

Prana Biotechnology Limited was incorporated under the laws of the Commonwealth of Australia on November 11, 1997. Our mission is to develop therapeutic drugs designed to treat the underlying causes of degeneration of the brain and the eye as the aging process progresses, initially focusing on Alzheimer’s disease. Other potential applications for our therapies include Huntington’s disease, Parkinson’s disease, certain cancers, age-related macular degeneration, Motor Neuron disease, Creutzfeldt-Jakob disease (the human variant of Mad Cow disease) and age-related cataracts. The principal listing of our ordinary shares and listed options to purchase our ordinary shares is on the Australian Stock Exchange. Since September 5, 2002, our American Depository Receipts, or ADRs, have ~~traded~~tr aded on the NASDAQ Capital Market under the symbol “PRAN.” The Bank of New York, acting as depositary, issues our ADRs, each of which evidences an American Depositary Share, which in turn represents ten of our ordinary shares. We have two wholly-owned subsidiaries, Prana Biotechnology Inc. and Prana Biotechnology UK Limited, incorporated in the United States and the United Kingdom, respectively, in August ~~2004.~~2004, both of which are currently inactive. As used in this annual report, the terms “we,” “us,” “our” and “Prana” mean Prana Biotechnology Limited and its subsidiaries, unless otherwise indicated.

We have not obtained or applied for ~~trademarks~~trademark registrations. Any trademarks and trade names appearing in this annual report are owned by their respective holders.

Our consolidated financial statements appearing in this annual report are prepared in Australian dollars and in accordance with the International Financial Reporting Standards, or IFRS, as issued by the International Accounting Standards Board, or IASB, which became effective for our company as of our fiscal year ended June 30, 2006. Our consolidated financial statements appearing in this annual report comply with both the IFRS and Australian equivalents to International Financial Reporting Standards, or A-IFRS.

In this annual report, all references to “U.S. dollars” or “US$” are to the currency of the United States of America, and all references to “Australian dollars” or “A$” are to the currency of Australia.

Statements made in this annual report concerning the contents of any contract, agreement or other document are summaries of such contracts, agreements or documents and are not complete descriptions of all of their terms. If we filed any of these documents as an exhibit to this annual report or to any registration statement or annual report that we previously filed, you may read the document itself for a complete description of its terms.

Except for the historical information contained in this annual report, the statements contained in this annual report are “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, as amended, with respect to our business, financial condition and results of operations. Such forward-looking statements reflect our current view with respect to future events and financial results. We urge you to consider that statements which use the terms “anticipate,” “believe,” “do not believe,” “expect,” “plan,” “intend,” “estimate,” and similar expressions are ~~intended~~intende d to identify forward-looking statements. We remind readers that forward-looking statements are merely predictions and therefore inherently subject to uncertainties and other factors and involve known and unknown risks that could cause the actual results, performance, levels of activity, or our achievements, or industry results, to be materially different from any future results, performance, levels of activity, or our achievements expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by applicable law, including the securities laws of the United States, we undertake no obligation to publicly release any update or revision to any forward-looking statements to reflect new information, future events or circumstances, or otherwise after the date hereof. We have attempted to identify significant uncertainties and other ~~factors~~fac tors affecting forward-looking statements in the Risk Factors section that appears in Item 3.D. “Key Information-Risk Factors.”

~~iii~~

TABLE OF CONTENTS

			~~Page~~




~~PART I~~			6 Page
PART I		5
ITEM 1.		IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERS	6 5
ITEM 2.		OFFER STATISTICS AND EXPECTED TIMETABLE	6 5
ITEM 3.		KEY INFORMATION	6 5
	A.	Selected Consolidated Financial Data	6 5
	B.	Capitalization and Indebtedness	8 7
	C.	Reasons for the Offer and Use of Proceeds	8 7
	D.	Risk Factors	8 7
ITEM 4.		INFORMATION ON THE COMPANY	16 15
	A.	History and Development of the Company	16 15
	B.	Business Overview	17
	C.	Organizational Structure	30 28
	D.	Property, Plants and Equipment	31 29
ITEM 4A.		UNRESOLVED STAFF COMMENTS	31 29
ITEM 5.		OPERATING AND FINANCIAL REVIEW AND PROSPECTS	31 29
	A.	Operating Results	31 29
	B.	Liquidity and Capital Resources	40 37
	C.	Research and Development, Patents and Licenses	42 39
	D.	Trend Information	43 40
	E.	Off-Balance Sheet Arrangements	43 40
	F.	Tabular Disclosure of Contractual Obligations	43 41
ITEM 6.		DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES	44 41
	A.	Directors and Senior Management	44 41
	B.	Compensation	46 43
	C.	Board Practices	48 45
	D.	Employees	51 48
	E.	Share Ownership	51 49
ITEM 7.		MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS	56 53
	A.	Major Shareholders	56 53
	B.	Related Party Transactions	58 55
	C.	Interests of Experts and Counsel	58 55
ITEM 8.		FINANCIAL INFORMATION	58 55
	A.	Financial Statements and Other Financial Information	58 55
	B.	Significant Changes	58 56
ITEM 9.		THE OFFER AND LISTING	59 56
	A.	Offer and Listing Details	59 56
	B.	Plan of Distribution	60 57
	C.	Markets	60 57
	D.	Selling Shareholders	60 57
	E.	Dilution	60 57
	F.	Expenses of the Issue	60 58
ITEM 10.		ADDITIONAL INFORMATION	60 58
	A.	Share Capital	60 58
	B.	Memorandum and Articles of Association	60 58
	C.	Material Contracts	62 59
	D.	Exchange Controls	64 62
	E.	Taxation	65 63
	F.	Dividends and Paying Agents	71 68
	G.	Statement by Experts	71 68
	H.	Documents on Display	71 68
	I.	Subsidiary Information	72
			69

iii






ITEM 11.	QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK	72 69
ITEM 12.	DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES	72 70

PART II		72 70

ITEM 13.	DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES	72 71
ITEM 14.	MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS	72 71
ITEM 15.	CONTROLS AND PROCEDURES	72 71
ITEM 16.	RESERVED	73 72
ITEM 16A.	AUDIT COMMITTEE FINANCIAL EXPERT	73 72
ITEM 16B.	CODE OF ETHICS	74 72
ITEM 16C.	PRINCIPAL ACCOUNTANT FEES AND SERVICES	74 73
ITEM 16D.	EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES	74 73
ITEM 16E.	PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS	74 73
ITEM 16F.	CHANGES IN ~~REGISTRANT'S~~REGISTRANT’S CERTIFYING ACCOUNTANT	75 74
ITEM 16G.	CORPORATE GOVERNANCE	75 74
ITEM 17.	FINANCIAL STATEMENTS	75 74
ITEM 18.	FINANCIAL STATEMENTS	75 74
ITEM 19.	EXHIBITS	75 74
SIGNATURES		78 77

PART I

ITEM 1.

IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERS

Not applicable.

ITEM 2.

OFFER STATISTICS AND EXPECTED TIMETABLE

Not applicable.

ITEM 3.

KEY INFORMATION

A.	~~SELECTED CONSOLIDATED FINANCIAL DATA~~Selected Consolidated Financial Data

We prepare our consolidated financial statements in accordance with IFRS, as issued by IASB, which became effective for our company as of our fiscal year ended June 30, 2006. Under IFRS 1, “First-time Adoption of International Financial Reporting Standards,” or IFRS 1, a company adopting IFRS for the first time is required to adopt accounting policies that comply with IFRS and related interpretations that are in effect at the reporting date of its first annual financial statements prepared in accordance with IFRS, in our case June 30, 2006. Our consolidated financial statements appearing in this annual report comply with both the IFRS as issued by IASB and Australian equivalents to International Financial Reporting Standards, or A-IFRS.

The following table presents our selected consolidated financial data as of the dates and for each of the periods indicated. The following selected consolidated financial data as of June 30, ~~2009~~2010 and ~~2008~~2009 and for the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007~~2008 have been derived from our audited consolidated financial statements and notes thereto included elsewhere in this annual report. The selected consolidated financial data as of June 30, 2008, 2007 ~~2006~~ and ~~2005~~2006 and for the years ended June 30, ~~2006~~2007 and ~~2005~~2006 have been derived from our audited consolidated financial statements and notes thereto which are not included in this annual report.

The selected consolidated financial data set forth below should be read in conjunction with and are qualified entirely by reference to Item 5. “Operating and Financial Review and Prospects” and our consolidated financial statements and notes thereto included elsewhere in this annual report.

Statement of Operations Data:

Year Ended June 30,
2009
2008
2007
2006
2005
(in A$, except number of shares)

Revenue from continuing operations. 428,193 490,943 507,150 762,023 892,135
Other income - 170 287 288,263 1,760,978

Research and development expenses (2,215,358 ) (5,757,168 ) (4,492,193 ) (7,613,045 ) (7,109,839 )
Research and development expenses
  - related party - - - - (577,757 )
Personnel expenses (3,832,804 ) (5,350,189 ) (4,554,731 ) (3,418,008 ) (5,750,929 )
Intellectual property expenses (1,107,534 ) (469,428 ) (600,232 ) (466,426 ) (729,583 )
Auditor and accounting expenses (129,998 ) (331,950 ) (260,117 ) (205,815 ) (202,032 )
Travel expenses (195,251 ) (146,651 ) (309,997 ) (212,184 ) (432,316 )
Public relations and marketing
  expenses (222,679 ) (141,337 ) (215,455 ) (134,750 ) (442,920 )
Depreciation expenses (34,190 ) (25,349 ) (58,582 ) (118,196 ) (65,223 )
Amortization expenses - - - - (83,200 )
Other expenses (978,875 ) (975,404 ) (1,008,563 ) (824,625 ) (1,204,930 )
Foreign exchange gain (loss) (6,723 ) (402,886 ) (757,578 ) 223,454 (1,362,572 )
Impairment of intangible assets - - - - (786,240 )
Gain (loss) on fair value of
  financial liabilities 772,430 (451,429 ) 607,691 128,715 5,801,397
Net loss (7,522,789 ) (13,560,678 ) (11,142,320 ) (11,590,594 ) (10,293,031 )
Loss per share - basic and diluted (0.04 ) (0.08 ) (0.08 ) (0.09 ) (0.08 )
Weighted average number of
  ordinary shares outstanding -
  basic and diluted 202,357,885 174,714,146 140,754,495 128,053,601 122,754,061

Statement of Operations Data:
	Year Ended June 30,
	2010			2009			2008			2007			2006
	(in A$, except number of shares)
Revenue from continuing operations		215,008			428,193			490,943			507,150			762,023
Other income		-			-			170			287			288,263

Research and development expenses, net		(87,992	)		(2,215,358	)		(5,757,168	)		(4,492,193	)		(7,613,045	)
Research and development expenses - related party		-			-			-			-			-
Personnel expenses		(3,087,234	)		(3,832,804	)		(5,350,189	)		(4,554,731	)		(3,418,008	)
Intellectual property expenses		(431,082	)		(1,107,534	)		(469,428	)		(600,232	)		(466,426	)
Auditor and accounting expenses		(168,909	)		(129,998	)		(331,950	)		(260,117	)		(205,815	)
Travel expenses		(234,555	)		(195,251	)		(146,651	)		(309,997	)		(212,184	)
Public relations and marketing expenses		(130,090	)		(222,679	)		(141,337	)		(215,455	)		(134,750	)
Depreciation expenses		(35,290	)		(34,190	)		(25,349	)		(58,582	)		(118,196	)
Amortization expenses		-			-			-			-			-
Other expenses		(940,699	)		(978,875	)		(975,404	)		(1,008,563	)		(824,625	)
Foreign exchange gain (loss)		(6,079	)		(6,723	)		(402,886	)		(757,578	)		223,454
Impairment of intangible assets		-			-			-			-			-
Gain (loss) on fair value of financial liabilities		-			772,430			(451,429	)		607,691			128,715
Net loss		(4,906,922	)		(7,522,789	)		(13,560,678	)		(11,142,320	)		(11,590,594	)
Loss per share – basic and diluted		(0.02	)		(0.04	)		(0.08	)		(0.08	)		(0.09	)
Weighted average number of ordinary shares outstanding - basic and diluted		227,527,388			202,357,885			174,714,146			140,754,495			128,053,601

Balance Sheet Data:

	As at June 30,
	2010			2009			2008			2007			2006
	(in A$ )
Cash and cash equivalents		5,227,298			4,304,977			11,219,035			7,409,256			10,013,778
Working capital*		5,135,625			3,643,502			9,762,015			5,564,304			7,698,283
Total assets		6,801,417			4,597,250			11,698,313			7,722,185			10,421,146
Net assets		5,229,316			3,749,816			9,866,327			5,612,195			7,800,658
Issued capital		75,120,164			70,188,989			69,842,303			53,988,412			46,274,127
Share based payment reserves		8,582,579			7,127,332			6,067,740			4,106,821			2,867,249
Accumulated deficit during development stage		(78,473,427	)		(73,566,505	)		(66,043,716	)		(52,483,038	)		(41,340,718	)
Total equity		5,229,316			3,749,816			9,866,327			5,612,195			7,800,658

As at June 30,
2009
2008
2007
2006
2005
(in A$ )

Cash and cash equivalents 4,304,977 11,219,035 7,409,256 10,013,778 21,453,304
Working capital* 3,643,502 9,762,015 5,564,304 7,698,283 18,370,555
Total assets 4,597,250 11,698,313 7,722,185 10,421,146 22,289,159
Net assets 3,749,816 9,866,327 5,612,195 7,800,658 18,536,769
Issued capital 70,188,989 69,842,303 53,988,412 46,274,127 45,838,897
Share based payment reserves 7,127,332 6,067,740 4,106,821 2,867,249 2,447,996
Accumulated deficit during
development stage (73,566,505 ) (66,043,716 ) (52,483,038 ) (41,340,718 ) (29,750,124 )
Total equity 3,749,816 9,866,327 5,612,195 7,800,658 18,536,769

*	~~Working capital is the difference between current assets and liabilities.~~

Working capital is the difference between current assets and liabilities.

Exchange Rate Information

The following tables set forth, for the periods and dates indicated, certain information regarding the rates of exchange of A$1.00 into US$ based on the noon market buying rate in New York City for cable transfers in Australian dollars as certified for customs purposes by the Federal Reserve Bank of New York, or the noon buying rate.

Year
Ended June 30,
At Period End
Average Rate
High
Low

2005 0.7620 0.7535 0.7988 0.6852
2006 0.7301 0.7478 0.7792 0.7014
2007 0.8488 0.7859 0.8521 0.7377
2008 0.9615 0.8965 0.9654 0.7672
2009 0.8048 0.7480 0.9849 0.6005

Month
High
Low

April 2009 0.7327 0.6846
May 2009 0.8012 0.7232
June 2009 0.8262 0.7789
July 2009 0.8271 0.7793
August 2009 0.8477 0.8155
September 2009 (until September 21) 0.8774 0.8239

Year Ended June 30,	At Period End		Average Rate		High		Low
2006		0.7301		0.7478		0.7792		0.7014
2007		0.8488		0.7859		0.8521		0.7377
2008		0.9615		0.8965		0.9654		0.7672
2009		0.8048		0.7480		0.9849		0.6005
2010		0.8567		0.8822		0.9405		0.7723

Month	High		Low
May 2010		0.9324		0.8069
June 2010		0.8855		0.8100
July 2010		0.9068		0.8323
August 2010		0.9221		0.8772
September 2010		0.9726		0.8861
October 2010		1.0330		0.9542

The noon buying rate on ~~September 22, 2009~~October 31, 2010 was US$~~0.8638~~0.9843 = A$1.00.

B.	~~CAPITALIZATION AND INDEBTEDNESS~~Capitalization and Indebtedness

Not applicable.

C.	~~REASONS FOR THE OFFER AND USE OF PROCEEDS~~Reasons for the Offer and Use of Proceeds

Not applicable.

D.	~~RISK FACTORS~~Risk Factors

Investing in our American Depositary Shares involves a high degree of risk and uncertainty. You should carefully consider the risks and uncertainties described below before investing in our American Depositary Shares. Additional risks and uncertainties not presently known to us or that we believe to be immaterial may also adversely affect our business. If any of the following risks actually occurs, our business, prospects, financial condition and results of operations could be harmed. In that case, the daily price of our depositary shares could decline, and you could lose all or part of your investment.

Risks Related To Our Business

We will require substantial additional financing in the future to sufficiently fund our operations and research.

We have been unprofitable to date and expect to incur losses over the next several years as we expand our drug discovery and development programs and pre-clinical testing and as we conduct clinical trials of our product candidates. Our actual cash requirements may vary materially from those now planned and will depend upon numerous factors, including:

—·

the continued progress of our research and development programs;

—·

the timing, scope, results and costs of pre-clinical studies and clinical trials;

—·

the cost, timing and outcome of regulatory submissions and approvals;

—·

determinations as to the commercial potential of our product candidates;

—·

our ability to successfully expand our contract manufacturing services;

—·

our ability to establish and maintain collaborative arrangements; and

—·

the status and timing of competitive developments.

We anticipate that we will require substantial additional funds within the next 12 months in order to achieve our long-term goals and complete the research and development of our pharmaceutical product candidates. In addition, we will require additional funds to pursue regulatory clearances, defend our intellectual property rights, establish commercial scale manufacturing facilities, develop marketing and sales capabilities and fund operating expenses. We intend to seek such additional funding through public or private financings and/or through licensing of our assets or strategic alliances or other arrangements with corporate partners. ~~However, such additional~~In August 2010, our shareholders approved a private placement of up to 225,000,000 of our ordinary shares (or ADRs represent ing 225,000,000 ordinary shares) at price per share of at least 80% of the average market price of our ordinary shares for the five trading days prior to the issuance of the shares. The private placement will be to clients of Southern Cross Equities Limited, other Australian financial service license holders and Quintiles Limited, or Quintiles. We intend to use the funds raised in the private placement to facilitate the funding of a Phase IIb clinical trial for PBT2 in patients with Alzheimer’s disease. We have not issued any shares or ADRs under the private placement to date. Such financing may not be available from any sources on acceptable terms, or at all, and we may not be able to license our assets or establish new strategic alliances or other arrangements with corporate partners on acceptable terms, or at all. The ~~current~~ global economic climate could adversely impact our ability to obtain such funding, license our assets or enter into alliances or other arrangements with corporate partners. Any shortfall in funding could result in our having to curtail or cease our operations, including our research and development activities, which would be expected to have a material adverse effect on our business, financial condition and results of operations.

~~If we do not obtain the necessary governmental approvals, we will be unable to commercialize our pharmaceutical products.~~

Our ongoing research and development activities are, and the production and marketing of our pharmaceutical product candidates derived from such activities will be, subject to regulation by numerous governmental authorities in Australia, principally the Therapeutics Goods Administration, or TGA; the Food and Drug Administration, or FDA, in the United States; the Medicines and Healthcare products Regulatory Agency, or MHRA, in the United Kingdom; the Medical Products Agency, or MPA, in Sweden; and the European Medicines Agency, or EMEA. Prior to marketing, any therapeutic product developed must undergo rigorous pre-clinical testing and clinical trials, as well as an extensive regulatory approval process mandated by the TGA and, to the extent that any of our pharmaceutical products under development are marketed abroad, by foreign regulatory agencies, including the FDA in the United States and the MHRA in the United Kingdom. These processes can take many years and require the expenditure of substantial resources. Governmental agencies may not grant regulatory approval due to matters arising form pre-clinical animal toxicology, safety pharmacology, drug formulation and purity, clinical side effect or patient risk profile, medical contraindications. Failure or delay in obtaining regulatory approvals would adversely affect the development and commercialization of our pharmaceutical product candidates. We may not be able to obtain the clearances and approvals necessary for clinical testing or for manufacturing and marketing our pharmaceutical product candidates.

We are a development stage company at an early stage in the development of pharmaceutical products and our success is uncertain.

We are a development stage company at an early stage in the development of our pharmaceutical products which are designed to treat the underlying causes of degeneration of the brain and the eye as the aging process progresses. We have not sufficiently advanced the development of any of our products, including our current lead product candidate, PBT2, to market or generate revenues from their commercial application. Our current or any future product candidates, if successfully developed, may not generate sufficient or sustainable revenues to enable us to be profitable.

We will not be able to commercialize our PBT2 therapeutic compound for Alzheimer’s disease or any future product candidates if we fail to adequately demonstrate their safety, efficacy and superiority over existing therapies.

Before obtaining regulatory approvals for the commercial sale of any of our pharmaceutical products, we must demonstrate through pre-clinical testing and clinical studies that our PBT2 product candidate is safe and effective for use in humans for each target indication. Conducting pre-clinical testing and clinical studies is an expensive, protracted and time-consuming process. Likewise, results from early clinical trials may not be predictive of results obtained in large-scale, later-stage clinical testing. In addition, even though a potential drug product shows promising results in clinical trials, regulatory authorities may not grant the necessary approvals without sufficient safety and efficacy data.

We may not be able to undertake further clinical trials of our PBT2 compound as a therapeutic compound for Alzheimer’s disease or other indications and any future product candidate (including one that may emerge from our vaccine program), or to demonstrate the safety and efficacy or superiority of any of these product candidates over existing therapies or other therapies under development, or enter into any collaborative arrangement to commercialize our current or future product candidates on terms acceptable to us, or at all. For example, in April 2005, we ceased clinical trials of our PBT1 compound as a treatment for Alzheimer’s disease. Clinical trial results that show insufficient safety and efficacy could have a material adverse effect on our business, financial condition and results of operations.

~~We have a history of operating losses and may not achieve or maintain profitability in the future.~~

We have incurred losses in every period since we began operations in 1997. We expect to continue to incur additional operating losses over at least the next several years and to increase our cumulative losses substantially as we expand our research and development and pre-clinical activities and commence additional clinical trials of PBT2. We reported net losses of A$7,522,789, A$13,560,678 and A$11,142,320 during the fiscal years ended June 30, 2009, 2008 and 2007, respectively. As of June 30, 2009, our accumulated deficit was A$73,566,505. We may never be able to achieve or maintain profitability.

We may experience delays in our clinical trials that could adversely affect our business and operations.

We do not know whether planned clinical trials will begin on time or whether we will complete any of our clinical trials on schedule or at all. Our ability to commence and complete clinical trials may be delayed by many factors, including:

—·

government or regulatory delays, including delays in obtaining approvals from applicable hospital ethics committees and internal review boards;

—·

slower than expected patient recruitment;

—·

our inability to manufacture sufficient quantities of our new proprietary compound or our other product candidates or matching controls;

—·

unforeseen safety issues; and

—·

lack of efficacy or unacceptable toxicity during the clinical trials.

Patient enrollment is a function of, among other things, the nature of the clinical trial protocol, the existence of competing protocols, the size and longevity of the target patient population, and the availability of patients who comply with the eligibility criteria for the clinical trial. Delays in planned patient enrollment may result in increased costs, delays or termination of clinical trials. Moreover, we rely on third parties to assist us in managing and monitoring clinical trials. Any failure by these third parties to perform under their agreements with us may cause the trials to be delayed or result in a failure to complete the trials.

Product development costs to our collaborators and us will increase if we have delays in testing or approvals or if we need to perform more, larger or more complex clinical trials than planned. Significant delays could have a material adverse effect on the commercial prospects of our product candidates and our business, financial condition and results of operations.

We have a history of operating losses and may not achieve or maintain profitability in the future.

We have incurred losses in every period since we began operations in 1997. We expect to continue to incur additional operating losses over at least the next several years and to increase our cumulative losses substantially as we expand our research and development and pre-clinical activities and commence additional clinical trials of PBT2. We reported net losses of A$4,906,922, A$7,522,789 and A$13,560,678 during the fiscal years ended June 30, 2010, 2009 and 2008, respectively. As of June 30, 2010, our accumulated deficit was A$78,473,427. We may never be able to achieve or maintain profitability.

There is a substantial risk that we may not be able to complete the development of PBT2 or develop other pharmaceutical products.

We may not be able to progress with the development of our current or any future pharmaceutical product candidates to a stage that will attract a suitable collaborative partner for the development of any current or future pharmaceutical product candidates. The projects initially specified in connection with any such collaboration and any associated funding may change or be discontinued as a result of changing interests of either the collaborator or us, and any such change may change the budget for the projects under the collaboration. Additionally, our research may not lead to the discovery of additional product candidates, and any of our current and future product candidates may not be successfully developed, prove to be safe and efficacious in clinical trials, meet applicable regulatory standards and receive ~~regulatory~~regul atory approval, be capable of being produced in commercial quantities at reasonable costs, or be successfully or profitably marketed, either by us or a collaborative ~~partner.The~~partner. The products we develop may not be able to penetrate the potential market for a particular therapy or indication or gain market acceptance among health care providers, patients and third-party payers. We cannot predict if or when the development of PBT2 or any future pharmaceutical product will be completed or commercialized, whether funded by us, as part of a collaboration or through a grant.

If we do not obtain the necessary governmental approvals, we will be unable to commercialize our pharmaceutical products.

Our ongoing research and development activities are, and the production and marketing of our pharmaceutical product candidates derived from such activities will be, subject to regulation by numerous governmental authorities in Australia, principally the Therapeutics Goods Administration, or TGA; the Food and Drug Administration, or FDA, in the United States; the Medicines and Healthcare products Regulatory Agency, or MHRA, in the United Kingdom; the Medical Products Agency, or MPA, in Sweden; and the European Medicines Agency, or EMEA. Prior to marketing, any therapeutic product developed must undergo rigorous pre-clinical testing and clinical trials, as well as an extensive regulatory approval process mandated by the TGA and, to the extent that any of our pharmaceutical products under development are marketed abroad, by forei gn regulatory agencies, including the FDA in the United States and the MHRA in the United Kingdom. These processes can take many years and require the expenditure of substantial resources. Governmental agencies may not grant regulatory approval due to matters arising from pre-clinical animal toxicology, safety pharmacology, drug formulation and purity, clinical side effects or patient risk profiles, or medical contraindications. Failure or delay in obtaining regulatory approvals would adversely affect the development and commercialization of our pharmaceutical product candidates. We may not be able to obtain the clearances and approvals necessary for clinical testing or for manufacturing and marketing our pharmaceutical product candidates.

We may need to prioritize the development of our most promising candidates at the expense of the development of other products.

We may need to prioritize the allocation of development resources and/or funds towards what we believe to be our most promising product or products. The nature of the drug development process is such that there is a constant availability of new information and data which could positively or adversely affect a product in development. We cannot predict how such new information and data may impact in the future the prioritization of the development of our current or future product candidates or that any of our products, regardless of its development stage or the investment of time and funds in its development, will continue to be funded or developed.

Our research and development efforts will be seriously jeopardized if we are unable to retain key personnel and cultivate key academic and scientific collaborations.

Our future success depends to a large extent on the continued services of our senior management and key scientific personnel. We have entered into employment or consultancy agreements with these individuals. The loss of their services could negatively affect our business. Our success is highly dependent on the continued contributions of our scientific personnel and on our ability to develop and maintain important relationships with leading academic institutions and scientists. Competition among biotechnology and pharmaceutical companies for qualified employees is intense, and we may not be able to continue to attract and retain qualified scientific and management personnel critical to our success. We also have relationships with leading academic and scientific collaborators who condu ct research at our request or assist us in formulating our research and development strategies. These academic and scientific collaborators are not our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limit their availability to us. In addition, these collaborators may have arrangements with other companies to assist such companies in developing technologies that may prove competitive to ours.

If we are unable to successfully keep pace with technological change or with the advances of our competitors, our technology and products may become obsolete or non-competitive.

The biotechnology and pharmaceutical industries are subject to rapid and significant technological change. Our competitors in Australia and elsewhere are numerous and include major pharmaceutical companies, biotechnology firms, universities and other research institutions. These competitors may develop technologies and products that are more effective than any that we are developing, or which would render our technology and products obsolete or non-competitive. Many of these competitors have greater financial and technical resources and manufacturing and marketing capabilities than we do. In addition, many of our competitors have much more experience than we do in pre-clinical testing and human clinical trials of new or improved drugs, as well as in obtaining FDA, TGA, MHRA, MPA, EMEA and other regulatory approvals.

We know that competitors are developing or manufacturing various technologies or products for the treatment of diseases that we have targeted for product development. Some of these competitive products use therapeutic approaches that compete directly with our PBT2 product candidate. Our ability to further develop our products may be adversely affected if any of our competitors were to succeed in obtaining regulatory approval for their competitive products sooner than us.

Acceptance of our products in the marketplace is uncertain, and failure to achieve market acceptance will negatively impact our business and operations.

Our current or future products may not achieve market acceptance even if they are approved by the TGA, FDA or any other regulatory authority. The degree of market acceptance of such products will depend on a number of factors, including:

the receipt and timing of regulatory approvals for the uses that we are studying;

the establishment and demonstration to the medical community of the safety, clinical efficacy and cost-effectiveness of our product candidates and their potential advantages over existing therapeutics and technologies; and

the pricing and reimbursement policies of governments and third-party payors.

Physicians, patients, payors or the medical community in general may be unwilling to accept, use or recommend any of our products.

Our success depends upon our ability to protect our intellectual property and our proprietary technology.

Any future success will depend in large part on whether we can:

—·

obtain and maintain patents to protect our own products and technologies;

—·

obtain licenses to the patented technologies of third parties;

—·

operate without infringing on the proprietary rights of third parties; and

—·

protect our trade secrets, know-how and other confidential information.

Patent matters in biotechnology are highly uncertain and involve complex legal and factual questions. Accordingly, the availability and breadth of claims allowed in biotechnology and pharmaceutical patents cannot be predicted. Any of the pending or future patent applications filed by us or on our behalf may not be approved, or we may not develop additional proprietary products or processes that are patentable or that we will be able to license any other patentable products or processes.

Our commercial success will also depend, in part, on our ability to avoid infringement of patents issued to others. If a court determines that we were infringing any third party patents, we could be required to pay damages, alter our products or processes, obtain licenses or cease certain activities. Licenses required under patents held by third parties may not be made available on terms acceptable to us or at all. To the extent that we are unable to obtain such licenses, we could be foreclosed from the development, export, manufacture or commercialization of the product requiring such license or encounter delays in product introductions while we attempt to design around such patents, and any of these circumstances could have a material adverse effect on our business, financial condition and results of ~~operations.~~

op erations.

We may have to resort to litigation to enforce any patents issued or licensed to us or to determine the scope and validity of third party proprietary rights. We may have to defend the validity of our patents in order to protect or enforce our rights against a third party. Third parties may in the future assert against us infringement claims or claims that we have infringed a patent, copyright, trademark or other proprietary right belonging to them. Any infringement claim, even if not meritorious, could result in the expenditure of significant financial and managerial resources and could negatively affect our profitability. While defending our patents, the scope of the claim may be reduced in breadth and inventorship of the claimed subject matter, and proprietary interests in the claimed subject matter may be altered or reduced. Any such litigation, regardless of outcome, could be expensive and time consuming, and adverse determinations in any such proceedings could prevent us from developing, manufacturing or commercializing our products and could have a material adverse effect on our business, financial condition and results of operations.

We have limited manufacturing experience with our product candidates. Delays in manufacturing sufficient quantities of such materials to the required standards for pre-clinical and clinical trials may negatively impact our business and operations.

We may not be able to manufacture sufficient quantities of PBT2 or any other development or product candidates in a cost-effective or timely manner. Manufacturing includes the production, formulation and stability testing of an active pharmaceutical ~~ingredient.~~ingredient and its formulation into pharmaceutical products, such as capsules or tablets. Any delays in production would delay our pre-clinical and human clinical trials, which could have a material adverse effect on our business, financial condition and operations.

We may be required to enter into contracting arrangements with third parties to manufacture PBT2 and any other development or product candidates for large-scale, pre-clinical and/or clinical trials. We may not be able to make the transition from laboratory-scale to development-scale or from development-scale to commercial production. We may need to develop additional manufacturing resources, enter into collaborative arrangements with other parties who have established manufacturing capabilities, or have third parties manufacture our products on a contract basis. We may not have access on acceptable terms to the necessary and substantial financing that would be required to scale-up production and develop effective commercial manufacturing processes and technologies. We may not be able to enter ~~into~~i nto collaborative or contracting arrangements on acceptable terms with parties that will meet our requirements for quality, quantity and timeliness.

We expect that we will be required to design and develop new synthetic pathways for most, if not all, of the products that we currently intend to develop or may develop in the future. We can not predict the success of such efforts, the purity of the products that may be obtained or the nature of the impurities that may result from such efforts. If we are not able to obtain an acceptable purity for any product candidate or an acceptable impurity profile, pre-clinical and clinical trials would be delayed, which could have a material adverse effect on the priority of the development of our product candidates, our business, financial condition and results of operations.

We are dependent upon a sole manufacturer of our lead compound, PBT2, and on a sole manufacturer to encapsulate the compound and could incur significant costs and delays if we are unable to promptly find a replacement for either of them.

We typically rely on a single manufacturer to develop Good Manufacturing Practice (GMP) synthetic processes for our lead compounds. Our lead compound, PBT2, ~~has been~~was manufactured ~~to date~~ by the Institute of Drug Technology Australia ~~Limited.~~Limited until early 2008. During late 2008, we transferred our PBT2 drug substance manufacturing process technology to Dr. Reddy’s Laboratories Limited based in Hyderabad, India to enable future and efficient large scale manufacture of PBT2 for any future prospective large scale clinical trial. We also rely on a sole manufacturer, Patheon Inc., to encapsulate PBT2. We intend to continue this approach, subject to ongoing appraisal of our manufacturing needs and financial position. We may not be able to promptly find a replacement manufacturer, if required, ~~without~~withou t incurring material additional costs and substantial delays.

~~Our research and development efforts will be seriously jeopardized if we are unable to retain key personnel and cultivate key academic and scientific collaborations.~~

Our future success depends to a large extent on the continued services of our senior management and key scientific personnel. We have entered into employment or consultancy agreements with these individuals. The loss of their services could negatively affect our business. Our success is highly dependent on the continued contributions of our scientific personnel and on our ability to develop and maintain important relationships with leading academic institutions and scientists. Competition among biotechnology and pharmaceutical companies for qualified employees is intense, and we may not be able to continue to attract and retain qualified scientific and management personnel critical to our success. We also have relationships with leading academic and scientific collaborators who conduct research at our request or assist us in formulating our research and development strategies. These academic and scientific collaborators are not our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limit their availability to us. In addition, these collaborators may have arrangements with other companies to assist such companies in developing technologies that may prove competitive to ours.

~~If we are unable to successfully keep pace with technological change or with the advances of our competitors, our technology and products may become obsolete or non-competitive.~~

~~Acceptance of our products in the marketplace is uncertain, and failure to achieve market acceptance will negatively impact our business and operations.~~

—

~~the receipt and timing of regulatory approvals for the uses that we are studying;~~

—

~~the pricing and reimbursement policies of governments and third-party payors.~~

~~Physicians, patients, payors or the medical community in general may be unwilling to accept, use or recommend any of our products.~~

The failure to establish a sales, marketing and distribution capability would materially impair our ability to successfully market and sell our pharmaceutical products.

We currently have no experience in marketing, sales or distribution of pharmaceutical products. If we develop any commercially marketable pharmaceutical products and decide to perform our own sales and marketing activities, we will require additional management, will need to hire sales and marketing personnel and will require additional capital. Qualified personnel may not be available in adequate numbers or at a reasonable cost. Further, additional financing may not be available on acceptable terms, or at all, and our sales staff may not achieve success in their marketing efforts. Alternatively, we may be required to enter into marketing arrangements with other parties who have established appropriate marketing, sales and distribution capabilities. We may not be able to enter into ~~marketing~~m arketing arrangements with any marketing partner, or if such arrangements are established, our marketing partners may not be able to commercialize our products successfully. Other companies offering similar or substitute products may have well-established and well-funded marketing and sales operations in place that will allow them to market their products more successfully. Failure to establish sufficient marketing capabilities would materially impair our ability to successfully market and sell our pharmaceutical products.

If healthcare insurers and other organizations do not pay for our products, or impose limits on reimbursement, our future business may suffer.

The drugs we hope to develop may be rejected by the marketplace due to many factors, including cost. The continuing efforts of governments, insurance companies, health maintenance organizations and other ~~payers~~payors of healthcare costs to contain or reduce healthcare costs may affect our future revenues and profitability and those of our potential customers, suppliers and collaborative partners, as well as the availability of capital. In Australia and certain foreign markets, the pricing or profitability of prescription pharmaceuticals is already subject to government control. We expect initiatives for similar government control at both the state and federal level to continue in the United States and elsewhere. The adoption of any such legislative or regulatory proposals could have a material ~~adverse~~advers e effect on our business and prospects.

Our ability to commercially exploit our products successfully will depend in part on the extent to which reimbursement for the cost of our products and related treatment will be available from government health administration authorities, private health coverage insurers and other organizations. Third-party payors, such as government and private health insurers, are increasingly challenging the price of medical products and services. Uncertainty exists as to the reimbursement status of newly approved health care products and in foreign markets, including the United States. If third-party coverage is not available to patients for any of the products we develop, alone or with collaborators, the market acceptance of these products may be reduced, which may adversely affect our future revenues and ~~profitability.~~profitabili ty. In addition, cost containment legislation and reductions in government insurance programs may result in lower prices for our products and could materially adversely affect our ability to operate profitably.

We may be exposed to product liability claims, which could harm our business.

The testing, marketing and sale of human health care products also entails an inherent risk of product liability. We may incur substantial liabilities or be required to limit development or commercialization of our products if we cannot successfully defend ourselves against product liability claims. We have historically obtained no fault compensation insurance for our clinical trials and intend to obtain similar coverage for future clinical ~~trials.Such~~trials. Such coverage may not be available in the future on acceptable terms, or at all. This may result in our inability to pursue further clinical trials or to obtain adequate protection in the event of a successful claim. We may not be able to obtain product liability insurance in the event of ~~the~~t he commercialization of a product or such insurance may not be available on commercially reasonable terms. Even if we have adequate insurance coverage, product liability claims or recalls could result in negative publicity or force us to devote significant time, attention and financial resources to those matters.

We may fail to maintain effective internal control over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act of 2002, which could have a material adverse effect on our operating results, investor confidence in our reported financial information, and the market price of our ordinary shares and ADRs.

The Sarbanes-Oxley Act of 2002 imposes certain duties on us and our executives and directors. Our efforts to comply with the requirements of Section 404 of the Sarbanes-Oxley Act of 2002, governing internal control and procedures for financial reporting, which started in connection with our Annual Report on Form 20-F for the year ended June 30, 2008, have resulted in increased general and administrative expenses and a diversion of management time and attention, and we expect these efforts to require the continued commitment of significant resources. We may identify material weaknesses or significant deficiencies in our assessments of our internal control over financial reporting. Failure to maintain effective internal control over financial reporting could result in investigations or sanctions by ~~regulatory~~regulato ry authorities and could have a material adverse effect on our operating results, investor confidence in our reported financial information, and the market price of our ordinary shares and ADRs.

Risks Relating to Our Securities

Our stock price may be volatile and the U.S. trading market for our American Depositary Shares is limited.

The market price for our securities, like that of the securities of other pharmaceutical and biotechnology companies, has fluctuated substantially and may continue to be highly volatile in the future. During the last two fiscal years, the market price for our ordinary shares on the Australian Stock Exchange has ranged from as low as A$0.12 to a high of A$~~0.69~~0.53 and the market price of our American Depositary Shares on the NASDAQ Capital Market has ranged from as low as US$11.00 to a high of US$~~6.73.~~5.06. The market price for our securities has been affected by both broad market developments and announcements relating to actual or potential developments concerning products under development. We believe that the following factors, in addition to other risk factors described above and elsewhere in this annual report , will continue to significantly affect the market price of our ordinary shares:

—·

the results of pre-clinical testing and clinical trials by us and our competitors;

—·

developments concerning research and development, manufacturing, and marketing alliances or collaborations by us and our competitors;

—·

announcements of technological innovations or new commercial products by us and our competitors;

—·

determinations regarding our patent applications, patents and those of others;

—·

publicity regarding actual or potential results relating to medicinal products under development by us and our competitors;

—·

proposed governmental regulations and developments in Australia, the United States and elsewhere;

—·

litigation;

—·

economic and other external factors; and

—·

period-to-period fluctuations in our operating results.

In addition, stock markets have experienced extreme price and volume fluctuations. These fluctuations have especially affected the stock market price of many high technology and healthcare related companies, including pharmaceutical and biotechnology companies, and, in many cases, are unrelated to the operating performance of the particular companies. Market fluctuations, as well as general political and economic conditions, such as a recession, interest rate or currency rate fluctuations, could adversely affect the market price of our securities.

Your ownership interest in our company may be diluted as a result of additional financings.

We may seek to raise funds from time to time in public or private issuances of equity, and such financings may take place in the near future or over the longer term. In August 2010, our shareholders approved a private placement of up to 225,000,000 of our ordinary shares (or ADRs representing 225,000,000 ordinary shares) at price per share of at least 80% of the average market price of our ordinary shares for the five trading days prior to the issuance of the shares. The private placement will be to clients of Southern Cross Equities Limited, other Australian financial service license holders and Quintiles. The ordinary shares will be issued no later than three months after the date of the shareholder approval (or such later date as may be permitted by an ASX waiver of the Listing Rules, the Corporations Act 2001 or the Australian Securities and Investments Commission). We intend to use the funds raised in the private placement to facilitate the funding of a Phase IIb clinical trial for PBT2 in patients with Alzheimer’s disease. Any such financing may dilute the relative holdings of our current shareholders.

There is a substantial risk that we are a passive foreign investment company, or PFIC, which will subject our U.S. investors to adverse tax rules.

Holders of our ADRs who are U.S. residents face income tax risks. There is a substantial risk that we are a passive foreign investment company, commonly referred to as PFIC. Our treatment as a PFIC could result in a reduction in the after-tax return to the holders of our ADRs and would likely cause a reduction in the value of such ADRs. For U.S. federal income tax purposes, we will be classified as a PFIC for any taxable year in which either (i) 75% or more of our gross income is passive income, or (ii) at least 50% of the average value of all of our assets for the taxable year produce or are held for the production of passive income. For this purpose, cash is considered to be an asset that produces passive income. As a result of our substantial cash position and the decline in the ~~value~~v alue of our stock, we believe that we became a PFIC during the taxable year ended June 30, 2005, and once again qualified as a PFIC during each of the ~~taxable~~last five fiscal years, ~~ended June 30, 2006, 2007, 2008 and 2009,~~ under a literal application of the asset test described above, which looks solely to market value. We believe that we will once again qualify as a PFIC during the taxable year ended June 30, ~~2010.~~2011. If we are classified as a PFIC for U.S. federal income tax purposes, highly complex rules would apply to U.S. holders owning ADRs. Accordingly, you are urged to consult your tax advisors regarding the application of such rules. United States residents should carefully read “Item 10.E. Additional Information –- Taxation, United States Federal Income Tax Consequences” for a more complete discussion of the U.S. federal income tax risks related to owning and disposing of our ADRs.

We do not anticipate paying dividends on our ordinary shares.

We have never declared or paid cash dividends on our ordinary shares and do not expect to do so in the foreseeable future. The declaration of dividends is subject to the discretion of our Board of Directors and will depend on various factors, including our operating results, financial condition, future prospects and any other factors deemed relevant by our board of directors. You should not rely on an investment in our company if you require dividend income from your investment in our company. The success of your investment will likely depend entirely upon any future appreciation of the market price of our ordinary shares, which is uncertain and unpredictable. There is no guarantee that our ordinary shares will appreciate in value or even maintain the price at which you purchased your ordinary shares.

Risks Relating to our Location in Australia

It may be difficult to enforce a judgment in the United States against us and our officers and directors or to assert U.S. securities laws claims in Australia or serve process on our officers and directors.

We are incorporated in Australia. All of our executive officers and directors are nonresidents of the United States. Therefore, it may be difficult for an investor, or any other person or entity, to enforce a U.S. court judgment based upon the civil liability provisions of the U.S. federal securities laws in an Australian court against us or any of those persons or to effect service of process upon these persons in the United States. Additionally, it may be difficult for an investor, or any other person or entity, to enforce civil liabilities under U.S. federal securities laws in original actions instituted in Australia.

As a foreign private issuer whose shares are listed on the NASDAQ Capital Market, we may follow certain home country corporate governance practices instead of certain NASDAQ requirements.

As a foreign private issuer whose shares are listed on the NASDAQ Capital Market, we are permitted to follow certain home country corporate governance practices instead of certain requirements of The NASDAQ ~~Marketplace~~Listing Rules. As an Australian company listed on the NASDAQ Capital Market, we may follow home country practice with regard to, among other things, the composition of the board of directors, director nomination process, compensation of officers and quorum at shareholders’ meetings. In addition, we may follow Australian law instead of the NASDAQ ~~Marketplace~~Listing Rules that require that we obtain shareholder approval for certain dilutive events, such as for the establishment or amendment of certain equity based compensation plans, an issuance that will result in a change of control of the company, certain ~~transactions~~transaction s other than a public offering involving issuances of a 20% or more interest in the company and certain acquisitions of the stock or assets of another company. A foreign private issuer that elects to follow a home country practice instead of NASDAQ requirements must submit to NASDAQ in advance a written statement from an independent counsel in such issuer’s home country certifying that the issuer’s practices are not prohibited by the home country’s laws. In addition, a foreign private issuer must disclose in its annual reports filed with the Securities and Exchange Commission each such requirement that it does not follow and describe the home country practice followed by the issuer instead of any such requirement. Accordingly, our shareholders may not be afforded the same protection as provided under NASDAQ’s corporate governance rules.

ITEM 4.

INFORMATION ON THE COMPANY

A.	~~HISTORY AND DEVELOPMENT OF THE COMPANY~~History and Development of the Company

Our legal and commercial name is Prana Biotechnology Limited. We were incorporated under the laws of the Commonwealth of Australia on November 11, 1997 and began limited operations shortly thereafter. Our registered office is located at Suite 2, 1233 High Street, Armadale, Victoria, 3143, Australia and our telephone number is 011-61-3-9824-8166. Our principal executive office is located at Level 2, 369 Royal Parade, Parkville, Victoria 3052, Australia and our telephone number is 011-61-3-9349-4906. Our address on the Internet iswww.pranabio.com. The information in our website is not incorporated by reference into this annual report.

Our mission is to develop therapeutic drugs designed to treat the underlying causes of degeneration of the brain and the eye as the aging process progresses, initially focusing on Alzheimer’s disease. Other potential applications for our therapies include Huntington’s disease, Parkinson’s disease, certain cancers, age-related macular degeneration, Motor Neuron disease, Creutzfeldt-Jakob disease (the human variant of Mad Cow disease) and age-related cataracts. Our technology is the outcome of many years of intense research from some of the leading scientists in the world in the area of age-related degenerative diseases.

Since completing our initial public offering and listing process of our ordinary shares on the ASX on March 28, 2000, we have concentrated our resources toward the pursuit of our disease targets. Initially we focused on clinical trials of our proof of concept compound, PBT1, as a therapeutic for the treatment of Alzheimer’s disease. On April 11, 2005, we announced that we would not proceed with the Phase II/III study as we had found unacceptably high levels of a di-iodo-8-hydroxyquinoline impurity that could potentially alter the risk of side-effects and mutagenicity. We considered methods to reduce the levels of the di-iodo impurity, however, we reached the conclusion that attempts to reduce the impurity to required levels were not likely to be successful in a timely, commercially viable manner and that further development of PBT1 for the treatment of Alzheimer’s disease was not appropriate.

On June 16, 2005, we announced that we had completed a review of our strategic development programs and we reaffirmed our commitment to PBT2, our current lead candidate for the potential treatment of Alzheimer’s disease. PBT2 was announced as a new lead metal protein attenuating compound, or MPAC, molecule for Alzheimer’s disease in early August 2003. PBT2 is the result of rational drug design. It was built “from the ground up” to fulfill very specific criteria. It was designed so that it will be orally bioavailable and cross the ~~blood brain~~blood-brain barrier. PBT2 was selected from over 300 compounds that had been developed by us at such time on the basis of its significant effectiveness in both pre-clinicalin vitro andin vivo testing. It was designed to have an improved safety and efficacy profile compared to PBT1. Phase I trials for PBT2 were completed by February 2006 in healthy young and aged volunteers and demonstrated that the drug was well tolerated and suitable for Phase II clinical development. During 2007, a Phase IIa clinical study was undertaken in elderly patients with Alzheimer’s disease over three months. The top line results were announced in February 2008, including the primary endpoints of safety and tolerability being met together with several secondary endpoints in biomarker and cognition endpoints also being met. In July 2008, the results of the Phase IIa trial were published inThe Lancet Neurology journal. The key findings included that PBT2 was well tolerated, with the safety profile of PBT2 being similar to that of the placebo, that the level of Abeta in the cerebrospinal fluid was significantly lowered and that two measures of executive cognitive function were improved in patients on the higher dose of PBT2. Also in July 2008, the results of extensive pre-clinical research findings for PBT2 were published in the journalNeuron.The key findings included the demonstration that PBT2 could rapidly improve cognition in transgenic mice, prevent the formation of toxic soluble Abeta oligomers, lower the Abeta levels in the brain of transgenic mice and protect neurons from the toxic effect of Abeta at the synapses between neurons enabling improved neurotransmission. ~~For details regarding clinical trials for PBT2, our lead compound, see Item 4.B. “Information on the Company – Business Overview – Clinical Trials for Our Lead Compound.”~~

In March 2009, we published further data on the impact of PBT2 on synapses in transgenic animal models. The findings demonstrated that PBT2 could prevent the loss of synapses in these ~~Alzheimer~~Alzheimer’s disease animal models, indicating that PBT2 has a ~~potent~~pote nt neuroprotective effect on neurons, consistent with the observation that PBT2 can improve cognitive performance in impaired transgenic animals.

In November 2009, an erratum to the July 2008 edition of The Lancet Neurology journal was published that corrected the original results of the neuropsychological test battery, or NTB, arising from the Phase IIa trial. The corrected results show that in addition to two measures of executive cognitive function found to be significantly improved, the overall executive function domain of the NTB, comprising five cognitive tests, was significantly improved for those patients taking 250mg of PBT2 compared to patients on placebo. In April 2010, we published an unblinded analysis of the responses of individual patients treated with PBT2 in the Phase IIa clinical trial in The Journal of Alzheimer’s Disease. The analysis demonstrates that there was a significant probability that any patient that showed cognitive executive function improvement in the trial was being treated with 250mg of PBT2. Moreover, 81% of patients taking the 250mg dose of PBT2 responded better on the executive function of the NTB score than the best performing patient on placebo. Improvement in ADAS-cog, a measure of memory and cognition, was observed in patients treated with 250mg of PBT2, almost reaching statistical significance by 12 weeks of the Phase IIa trial. The corrected cognitive data from the Phase IIa trial together with the additional analysis provides strong evidence of the ability of PBT2 to improve cognitive executive function as measured by the NTB. For details regarding clinical trials for PBT2, our lead compound, see Item 4.B. “Information on the Company - Business Overview - Clinical Trials for Our Lead Compound.”

In late July 2008, we received the findings from a report commissioned by us from U.S.-based clinical researchers on the suitability of PBT2 for Huntington’s disease. The report detailed the relevance of animal modeling experiments done with PBT2, its demonstrated mode of action in the brains of Huntington’s disease model mice and its promising safety and efficacy findings in the recently completed Alzheimer’s disease Phase IIa study with PBT2. The report concluded that PBT2 was recommended to proceed to clinical trials in Huntington’s disease research participants.

In August 2009, a key patent protecting our clinical drug asset PBT2 was granted in Europe by the European Patent ~~Office.~~Office, or the EPO. The patent entitled ‘8-Hydroxyquinoline derivatives’ covers the composition of matter of selected families of 8-Hydroxyquinoline compounds, including PBT2, and the uses of such compounds for the treatment of neurological diseases, including Alzheimer’s disease and Huntington’s disease. The European patent has a 20 year term expiring on July 16, 2023, with a possible extension of the term of up to five additional years under supplementary protection provisions. In July of 2010, we received notification from the EPO that the mandatory nine month post grant opposition period had expired in Europe and that the patent had been entered into the European Re gister of Patents. Also in August 2009, we received a notice of allowance from the United States Patent and Trade Mark Office, or USPTO, for our key patent protecting our clinical drug asset PBT2. The patent ~~is due to be~~was granted ~~by the end of the 2009 calendar year.~~in November 2009. The U.S. patent, which is also entitled ‘8-Hydroxyquinoline derivatives,’ covers the composition of matter of selected families of 8-Hydroxyquinoline compounds, including PBT2. ~~This~~In April 2010, the USPTO granted a recalculation of such U.S. patent ~~has been granted~~term to extend it by 889 days and accordingly, such patent will expire on December 21, 2010. It is possible that the patent may be further extended in ~~New Zealand, Singapore, South Africa and Russia and patent applications are pending~~the future under the pharmaceutical extension of term provisions that apply in ~~Australia, Brazil, Canada, China, India, Israel, Japan, South Korea and Mexico. Registration~~the United States.

In September 2009, we received a report on a study conducted on PBT519, our lead brain cancer MPAC, by the Royal Melbourne Hospital. The report showed that PBT519 was able to significantly prevent the growth of the ~~patent~~tumors of the deadly glioblastoma multiforme form of brain cancer in ~~Hong Kong has~~mouse models of the disease. Moreover, PBT519 appeared to be very well tolerated and was at least as efficacious as the current leading form of chemotherapy, temozolomide. The data indicates that PBT519 may work synergistically with temozolomide in reducing the growth of such brain tumors.

In September 2010, we announced that we have selected a new novel lead drug candidate with potential to be developed as a disease modifying treatment for Parkinson’s disease, PBT434. See Item 4.B “Business Overview - Platform Technology and Research Programs - Parkinson's Disease.”

On August 17, 2010, our shareholders approved a private placement of up to 225,000,000 of our ordinary shares (or ADRs representing 225,000,000 ordinary shares) at price per share of at least 80% of the average market price of our ordinary shares for the five trading days prior to the issuance of the shares. The private placement will be to clients of Southern Cross Equities Limited, other Australian financial service license holders and Quintiles. The ordinary shares will be issued no later than three months after the date of the shareholder approval (or such later date as may be permitted by an ASX waiver of the Listing Rules, the Corporations Act 2001 or the Australian Securities and Investments Commission). The shareholders also ~~been processed.~~

approved the participation of our directors in the private placement. 0; We intend to use the funds raised in the private placement to facilitate the funding of a Phase IIb clinical trial for PBT2 in patients with Alzheimer’s disease.

Since inception, we have not been required to invest material amounts for capital expenditures since our development efforts have taken place at research facilities operated by institutions with ~~whom~~which we have relationships. In the three fiscal years ended June 30, ~~2009,~~2010, our capital expenditures have totaled A$~~141,577.~~99,795. Since July 1, ~~2009,~~2010, we have incurred A$~~3,241~~3,216 in capital expenditures.

B.	~~BUSINESS OVERVIEW~~Business Overview

Prana’s Background

Medical science has made a significant number of breakthroughs over the past century. The average life span in western cultures has substantially increased. The diseases associated with aging have, however, yet to be fully understood or effectively treated. It is now believed that a number of age-related diseases may be capable of being treated.

The protein believed to be involved in the toxicity associated with Alzheimer’s disease is beta amyloid. Very little was known about beta-amyloid protein until 1984 when Professors Colin Masters, Konrad Beyreuther and the late Dr. George Glenner sequenced the chemistry of the protein which has since become the dominant focus ~~world-wide~~ of Alzheimer’s disease ~~research.~~

research world-wide.

In 1987, ~~Professors.~~Professors Masters, Beyreuther and Rudi Tanzi of Harvard Medical School discovered how beta-amyloid was produced and in 1994, Professor Ashley Bush of Harvard Medical School discovered that the interaction between metals and beta-amyloid is associated with the toxicity seen in Alzheimer’s disease, hopefully paving the way for the development of therapeutic drugs to treat the disease.

Our intellectual property has been developed over an extended period through the collaborative efforts of highly regarded scientists and research institutions in this field.

Research Institutions

The intellectual property owned by our company has been developed at several internationally recognized institutional research facilities, listed below, and through a team of scientists employed or engaged by our company who are based at the University of Melbourne:

–·

The Massachusetts General Hospital, Genetics and Aging Unit in Boston. Massachusetts General Hospital is the largest teaching hospital for Harvard Medical School;

–·

The University of Melbourne, Department of Pathology;

–·

The Mental Health Research Institute in Melbourne; and

–·

The Biomolecular Research Institute in Melbourne.

Work conducted at the first three of these institutions demonstrated that clioquinol, codenamed PBT1, had potential efficacy for the treatment of Alzheimer’s disease. Our research efforts led to the development of a novel MPAC within the same chemical class as PBT1, PBT2, a low molecular weight chemical entity that demonstrates a significant pre-clinical improvement over PBT1, and a library of approximately ~~500~~600 MPAC molecules in total (approximately 200 of which are of the same chemical class as PBT1 with the remaining MPACs of other chemical classes). Our research program aims to find further and potentially more effective preferred compounds for the treatment of Alzheimer’s disease as well as for our other major disease indications (such as Huntington’s disease, Parkinson’s disease, certain cancers and age-related macular degeneration).

Platform Technology and Research Programs

We regard our intellectual property as a “platform technology” since we believe that it addresses the causes of a broad spectrum of age-related diseases based on the interrelationship of metals and proteins. To date, the majority of our research efforts have been directed at research into potential therapeutics for the treatment of Alzheimer’s disease. Published data together with our initial findings have provided strong indications that the pathology for other certain age-related and degenerative disorders may also be based on the inter-relationship between certain metals and proteins, and we believe that the platform technology may also be applicable for: Huntington’s disease; Parkinson’s disease; certain cancers; age-related macular degeneration; Motor Neuron disease; ~~Creutzfeldt-Jakob~~Creutzfeldt-Ja kob disease; age-related cataracts; and other neurodegenerative diseases.

Alzheimer’s Disease. Research is ongoing to increase our understanding of the neuropathology of Alzheimer’s disease. Our research continues to focus on the structure and function of beta-amyloid and its precursor, and protein structural studies specifically around the sites of interaction between metals, metal complexes and our MPACs and the significant proteins in Alzheimer’s disease, such as Amyloid Precusor Protein and beta-amyloid. PBT2, our lead compound from our MPAC library for Alzheimer’s disease, has been extensively tested in bothin vitro andin vivo animal models for its ability to reduce both the amount of Abeta and its toxic effects in the brain. Results of the research, which were published in the journalNeuron in July 2008, demonstrate that PBT2 can rapidly improve cognition in transgenic mice, prevent the formation of toxic soluble Abeta oligomers, lower the Abeta levels in the brain of transgenic mice and protect neurons from the toxic effect of Abeta at the synapses (the space) between neurons, enabling improved neurotransmission. Experimental work during 2008 and 2009 has shown that PBT2 can also prevent the loss of neuronal synapses, a feature of the brain degeneration associated with Alzheimer’s disease. During 2009 and 2010, our scientists further examined the apparent link between aging and disease related defects due to metal imbalances in the brain. In February 2010, we reported in The Journal of Neuroscience on the loss of synaptic zinc uptake mechanisms in aged animal models and how this correlated with cognitive impairment. Our scientists also investigated the molecular basis for the neuroprotective qualities of PBT2 in animal models of Alzheimer’s disease. They found that several important intracellular signaling pathways required for neuronal function were stimulated when animals were treated with PBT2. These findings provide an insight into how PBT2 helps preserve and protect neurons in Alzheimer’s disease and also in animal models of Huntington’s disease. For a description of the history and development of our lead MPAC, PBT2, as a therapeutic for the treatment of Alzheimer’s disease, see Item 4.B. “Information on the Company –- Business Overview –- Clinical Trials for Our Lead Compound.”

Our research into the interaction of metals with Abeta protein has resulted in the identification of agents which can block the metal binding site on Abeta thereby preventing the downstream toxicity of Abeta protein on neurons. This therapeutic approach to Alzheimer’s disease is an alternative and complimentary drug strategy to our MPACs, which directly compete with Abeta protein by binding metals such as copper and zinc. Results from several proof-of-concept compounds were published in the Proceedings of theNational Academy of Sciences Journal in May 2008. In addition to their use as Alzheimer disease therapeutics, these amyloid binding compounds may also have potential as novel imaging agents, binding Abeta in the brain. Our ~~discovery~~disc overy program is generating novel forms of this alternative anti-amyloid class of compounds for testing in animal models as either therapeutic or diagnostic agents.

Metals, in particular copper, may cause Abeta protein to form specific toxic oligomers that inhibit normal neurotransmission in the brain. Accordingly, these toxic oligomers present a novel immunological target for vaccine research. Since 2004, we have undertaken a program to create a monoclonal antibody that only recognizes specific forms of the toxic Abeta oligomers and not other forms of Abeta protein. A candidate monoclonal antibody has been identified and will be tested for its efficacy and safety in a prospective mouse passive vaccine trial. However, initiation of the trial has been indefinitely delayed due to difficulties in the scale up and purification of the monoclonal antibody. ~~We will be utilizing the resources of the Mental Health Research Institute to conduct a prospective mouse passive vaccine trial.~~

~~Huntington’s~~Huntington's Disease.Huntington’s disease is a crippling genetic neurodegenerative disorder of the central nervous system caused by a mutation in a gene which encodes the huntingtin protein. The disease results in progressive deterioration of physical, cognitive and emotional abilities that lead to severe incapacitation and eventually death, generally 15-25 years after the onset of the disease. Huntington’s disease primarily affects adults, usually between the ages of 30 and 50.

U.S.-based researchers have presented the effects of clioquinol in an animal model of Huntington’s disease, showing evidence of improved behavior, motor skills and inhibition of the abnormal form of the huntingtin protein. Based on these findings, we have tested several proprietary MPACs in collaboration with ~~researchersbased atthe~~researchers based at the Veterans Affairs Medical Center and the Department of Neurology, University of California, San Francisco, under a collaborative research agreement. PBT2 has shown good efficacy in the R6/2 mouse model of Huntington’s disease.

Further work undertaken by our scientists during 2009 and 2010 on the neuroprotective qualities of PBT2 provides further evidence that PBT2 may be considered for clinical application in Huntington’s disease. Others scientists have previously published data that demonstrates that the levels of copper in the brains of Huntington’s disease animals, such as the R6/2 mouse model, have elevated levels of copper relative to normal mice and that copper promotes the aggregation of the mutant Huntington protein formed in the brains of affected animals. Our scientists hypothesize that PBT2 may benefit Huntington’s patients by preventing the aggregation of the huntingtin protein and through its neuroprotective properties, help to maintain normal neuronal function.

~~Parkinson’s~~Parkinson's Disease.Parkinson’s disease, another crippling disease of the aging population, causes a progressive slowing of movement, ~~tremor~~tremors and the loss of fine motor control due to the death ofsubstantia nigracells in the brain. Thesubstantia nigra cells produce the neurotransmitter dopamine in the brain, which is required for normal motor coordination. Increasingly, dementia is also being recognized as a significant component of Parkinson’s disease. Existing therapies, such as dopaminergic agents, may provide some short-term ~~symptomatic~~symptom atic relief, but do not address the underlying cause of the disease. We believe that our platform technology may affect the aggregation of the proteins concerned and may provide a pathway for reversing the disease. Parkinson’s disease ranks among the most common late life neurodegenerative diseases.

During 2005, we entered into a contractual arrangement with the Integrative Neuroscience Facility based at the Howard Florey Institute in Melbourne to assist in the examination of the effect of MPACs administered to the 6-hydroxydopamine (PD) mouse model of the disease, which concluded with positive results. In addition, groups unrelated to us have published data that demonstrates the usefulness of clioquinol in treating the symptoms of Parkinson’s disease generated in the alternative MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of the disease. These two mouse models mimic the disease by using these toxins to destroy over time the cells of the substantia nigra, the area of the brain affected in Parkinson’s disease, leading to ~~motor~~mot or function loss. Based on these positive results with clioquinol in such two mouse models, we began investigating the efficacy of other selected MPACs in these two models to screen for possible MPAC candidates as treatment candidates for Parkinson’s disease. Currently, we have identified six potential compound leads that demonstrate the ability to rescue thesubstantia nigra neuronal cells in both models of Parkinson’s disease, that otherwise perish over time as the disease progresses. ~~Final characterization~~During 2009 and ~~selection~~2010, a lead Parkinson’s disease candidate emerged, PBT434, which demonstrated significant ability to protect substantia nigra cells from the toxic effects of the two toxins, 6-hydroxydopamine and MPTP, when administered in the two models of Parkinson’s disease, and motor function and coordination was also markedly improved in both models. 60; This neuroprotection and motor improvement was observed when the candidate compound was administered after toxins had destroyed significant amounts of substantia nigra tissue, indicating that the compound can restore and maintain normal neuronal function. In September 2010, we announced that we have selected PBT434 as a ~~clinical development~~new novel lead ~~compound is underway.~~drug candidate with potential to be developed as a disease modifying treatment for Parkinson’s disease.

Brain Cancer. We have initiated a program of research into the potential use of selected MPACs from our library for use in the treatment of brain cancer, in particular the most prevalent and deadly form of the disease, Glioblastoma multiforme, or GBM. Patients with GBM have a very poor prognosis upon diagnosis with an estimated median survival of approximately 12 months. The most commonly prescribed treatments are chemotoxic agents together with radiation therapy, which confer a median survival increase of several months. There is an increasing body of published evidence that there are elevated levels of copper in tumors leading to increased cellular oxidative stress. Several of our MPACs that demonstrate ~~potent~~pot ent toxicity against human gliomablastoma cell lines and yet remain untoxic to normal brain cells are being tested in mouse models of GBM. We believe that MPACs with a strong ability to deliver copper into tumor cells will promote their death, and we are currently investigating thisin vivo.

In September 2009, we received a report on a study conducted on PBT519, our lead brain cancer MPAC, by the Royal Melbourne Hospital. The report showed that PBT519 was able to significantly prevent the growth of the tumors of the deadly GBM form of brain cancer in mouse models of the disease. Moreover, PBT519 appeared to be very well tolerated and was at least as efficacious as the current leading form of chemotherapy, temozolomide. The data indicates that PBT519 may work synergistically with temozolomide in reducing the growth of such brain tumors.

Clinical Trials for Our Lead Compound

In February 2005, we were awarded a research and development START grant of A$1.35 million to take PBT2 through safety testing and Phase I clinical trials for Alzheimer’s disease. Formal pre-clinical toxicology testing for PBT2 was completed and in March 2005, we commenced a series of Phase I clinical trials at a facility associated with the Utrecht University Hospital in Utrecht, the Netherlands. On November 7, 2005, we announced the successful completion of the first Phase I trial for PBT2, a double blind, placebo-controlled single dose escalation study, conducted on 55 healthy male volunteers between the ages of 18 and 50, which was designed to evaluate the safety, tolerability and pharmacokinetics of PBT2. Data from the study shows that PBT2 was well tolerated with little difference in the ~~incidence~~incid ence of adverse events between those receiving PBT2 and those receiving the placebo. Additionally, the pharmacokinetic analysis demonstrated that the drug exposure increased/decreased predictably and in a linear manner, both of which are desirable characteristics for a central nervous system drug. Concurrent findings in a pre-clinical mouse model indicate that PBT2 passes into the brain more extensively than its predecessor, PBT1. On February 7, 2006 we announced the completion of the second Phase I safety clinical trial for PBT2. This trial was a multi-dose escalation trial of PBT2 conducted in elderly, healthy male and female volunteers completed in December 2005. Volunteers were dosed at a selected dose for seven ~~days,~~days; the dose range was from 200mg to 800mg per day. Both Phase I trials demonstrated that PBT2 was well tolerated and suitable for progression to Phase II trials in ~~Alzheimer patients.~~

patients with Alzheimer’s disease.

In parallel to such clinical studies, chronic pre-clinical animal toxicology studies and the development work for GMP manufacture of PBT2 required for Phase II clinical studies was conducted and completed by the third calendar quarter of 2006. On July 20, 2006, while preparations for the Phase IIa clinical trial were underway, we announced key pre-clinical efficacy findings with PBT2 demonstrating that PBT2 could rapidly enhance memory function within five days of dosing in an ~~Alzheimer~~Alzheimer’s disease mouse model, improve synaptic function and significantly reduce soluble beta-amyloid protein levels in mouse models of Alzheimer’s disease in acute 24 hour experiments. On October 5, 2006, we announced the grant of approval from the Swedish Medical Products Agency (a Swedish regulatory authority) to undertake a Phase IIa clinical trial in elderly patients with mild ~~Alzheimer~~Alzheimer’s disease in Sweden. On December 19, 2006, we announced that dosing had commenced in the Phase IIa clinical trial. The Phase IIa trial iswas a three month double-blind, placebo-controlled safety and tolerability study of PBT2 in 80 elderly male and female patients with mild forms of Alzheimer’s disease. Tolerability, safety, cerebrospinal fluid and plasma biomarker and cognition endpoints ~~will be~~were measured. On August 6, 2007, we announced that 55 patients (of the planned 80) had been randomized to participate in the Phase IIa clinical trial, of which 30 patients had completed the trial, and that the independent Data Safety Monitoring Board, or DSMB, appointed by us upon the recommendation of Dr. Craig Ritchie and Quintiles, ~~Limited~~ for the Phase IIa clinical trial of PBT2 had reviewed the data of over 50 patients and concluded there have been no treatment-related serious adverse events or withdrawals ~~and~~an d that the trial was safe to continue in accordance with the original protocol. On September 24, 2007, we announced that the enrollment for the Phase IIa trial had been completed and that we expected to report results during the first calendar quarter of 2008. On November 29, 2007, we announced that the DSMB had completed its cycle of safety review meetings and reported to us that of the 59 patients included in the review at that time, there had been no treatment-related serious adverse events or withdrawals. The DSMB confirmed that the trial was safe to continue. Patient dosing was completed on December 18, 2007, and we announced the formal completion of the study on January 2, 2008. On February 26, 2008, we publicly released the top line trial results and announced that the trial primary endpoints of safety and tolerability were met. We also announced that with respect to the secondary endpoints, namely biomarker, cognition and behavioral ~~changes,~~ch anges, several significant and promising changes were observed. Specifically, that in the cerebrospinal fluid (CSF), PBT2 treatment at a 250mg dose resulted in a significant decrease in the target Abeta 42 protein. In addition, at the 250mg dose, while no significant effect was observed with the ADAS-cog, two of the ~~four neuropsychological test battery (NTB)~~five NTB tests for improvement in executive function were significantly improved. In July 2008, the results of the Phase IIa trial were published inThe Lancet Neurology journal. The key findings included the demonstration that PBT2 could rapidly improve cognition in transgenic mice, prevent the formation of toxic soluble Abeta oligomers, lower the Abeta levels in the brain of transgenic mice and protect neurons from the toxic effect of Abeta at the synapses between neurons enabling improved neurotransmission. Also in July 2008, the results of extensive pre-clinical research findings ~~for~~fo r PBT2 were published in the journalNeuron.The key findings included the demonstration that PBT2 could rapidly improve cognition in transgenic mice, prevent the formation of toxic soluble Abeta oligomers, lower the Abeta levels in the brain of transgenic mice and protect neurons from the toxic effect of Abeta at the synapses between neurons enabling improved neurotransmission. ~~Currently,~~

In November 2009, an erratum to the July 2008 edition of The Lancet Neurology journal was published that corrected the original results of the NTB cognitive findings arising from the Phase IIa trial. The corrected results show that in addition to two measures of executive cognitive function found to be significantly improved, the overall executive function domain of the NTB, comprising five cognitive tests, was significantly improved for those patients taking 250mg of PBT2 compared to patients on placebo. In April 2010, we ~~are considering~~published an analysis of the responses of individual patients treated with PBT2 in the Phase IIa clinical trial in the Journal of Alzheimer’s Disease. The analysis dem onstrated that there was a significant probability that any patient that showed cognitive executive function improvement in the trial was being treated with 250mg of PBT2. Moreover, 81% of patients on the 250mg dose of PBT2 responded better on the executive function of the NTB score than the best performing patient on placebo. Improvement in ADAS-cog, a measure of memory and cognition, was observed with patients treated with 250mg of PBT2, almost reaching statistical significance by 12 weeks of the Phase IIa trial. The corrected cognitive data from the Phase IIa trial together with the additional analysis provides strong evidence of the ability of PBT2 to improve cognitive executive function as measured by the NTB.

Also in November 2009, Prana presented its pre-clinical and clinical information package on PBT2 to the FDA in accordance with the Pre-Investigational New Drug (IND) Consultation Program. The meeting provided useful guidance on possible ~~larger scale Phase IIb trial designs that could be initiated during~~steps to take to open an IND Application with the FDA to undertake clinical trials in the United States in Alzheimer’s disease or Huntington’s disease. The meeting provided us with important information to help form our regulatory strategy for the development of PBT2 in these neurological indications.

During the first half of ~~2010.~~

2010, we developed a Phase IIb trial protocol to test PBT2 in a Phase II trial in patients with Alzheimer’s disease under the guidance of an international protocol steering committee. The protocol provides for a substantial trial measuring the effects of PBT2 on cognition and functional abilities in patients with mild to moderate Alzheimer’s disease. We have not yet scheduled a Phase IIb trial in patients with Alzheimer’s disease, which will require significant funding. In addition, we have begun to devise a protocol to test PBT2 in a Phase II trial in patients with Huntington’s disease.

Rational Drug Design

Rational drug design employs ~~experiment based~~experiment-based models, which target the molecular composition of various substances (in the case of Alzheimer’s disease the beta-amyloid protein) to allow the design of new chemical entities with the propensity to influence targeted substances and processes. In the case of MPACs, the targeted substances believed important are proteins and metals and the process of specific interest is believed to be metal-mediated oxyradical formation which leads to neurodegenerative changes.

Our medicinal chemistry program, ispreviously based at laboratories ~~that we lease at the~~leased from The University of ~~Melbourne.~~ Melbourne, was transferred in October 2009 to a laboratory leased from The University of Melbourne’s Bio21 Molecular Science and Biotechnology Institute, which is a multidisciplinary research centre that specializes in medical, agricultural and environmental biotechnology. Accommodating more than 500 research scientists, students and industry participants, the Bio21 Institute is one of the largest biotechnology research centers in Australia.

To date, our scientists have developed a pipeline of compounds across multiple chemical classes that target the interaction of specific metals and certain aggregating proteins such as beta-amyloid. Compounds continue to be designed, synthesized and undergo the required early phase pre-clinical screening before they are available for human ~~testing.Based~~testing. Based on the results of initial screening, our medicinal chemists continue to develop new chemical entities with novel design features and we believe that rational drug design will provide new and specifically designed drugs which will display efficacy in disaggregating aggregation-prone proteins such as beta-amyloid, ~~á-synuclein~~α-synuclein and huntingtin, paving the way for future therapeutics.

A series ofin vitro assays have been established to screen compounds developed by our medicinal chemistry group. From early 2002, a program was initiated by our medicinal chemistry group to undertake preliminaryin vivopharmacology and kinetic studies of the new compounds demonstrating activity in thein vitro screens. We performin vivo modeling for our lead compound candidates for Alzheimer’s disease with transgenic mice expressing a similar phenotype to human Alzheimer’s disease. Similarly, a transgenic mouse carrying a mutated Huntingtin gene is used to model ~~Huntington’s~~Hunt ington’s disease and mice treated with neuronal toxins to produce the Parkinson’s phenotype are used to model Parkinson’s disease. Based on the results of these studies, lead compounds are selected by our medicinal chemistry group for formal pre-clinical studies. Data generated by thesein vitro andin vivo screens are incorporated into our medicinal chemistry program to further refine development strategies for new compounds.

PBT2, our current Alzheimer’s disease lead MPAC product candidate, was selected from this “rationally designed” pipeline in 2003 and is the first such new and specifically designed compound to move into formal development. It has been built “from the ground up” to fulfill very specific criteria. It was designed so that it will be orally bioavailable and cross the ~~blood brain~~blood-brain barrier. PBT2 was selected from several hundred compounds that had been developed by us at such time. It has been designed to have an improved safety and pharmacokinetic profile and has demonstrated significant effectiveness in both pre-clinicalin vitro andin vivo testing. &# 160;For details regarding our PBT2 clinical trials see above in this Item 4.B. “Information on the Company –- Business Overview –- Clinical Trials for Our Lead Compound.”

MPACs from different chemical classes to ~~that~~those of PBT1 and PBT2, with different structural characteristics have shown differential behavior in screens for neurological disorders other than Alzheimer’s disease. For example, over the last few years we have generated a series of MPACs differentiated for their ability to be efficacious in animal models of Parkinson’s ~~disease. Currently we have identified six potential compound leads that demonstrate the ability to rescue the~~~~substantia nigra~~ ~~neuronal cells in both models of Parkinson’s~~ disease ~~which otherwise perish over time as the disease progresses. Final characterization~~ and ~~selection of a clinical development lead compound is underway. In addition, another series of chemically differentiated MPACs have shown promise~~~~in vitro~~~~assays of the~~ brain ~~cancer Glioblatoma multiforme and animal modeling is underway.~~

cancer.

Patents and Licenses

Patent Matters

Patent matters in biotechnology are highly uncertain and involve complex legal and factual questions. Accordingly, the availability and breadth of claims allowed in biotechnology and pharmaceutical patents cannot be predicted. Statutory differences in patentable subject matter may limit the protection we can obtain on some or all of our inventions outside Australia or prevent us from obtaining patent protection outside Australia, either of which could have a material adverse effect on our business, financial condition and results of operations. For example, methods of treating humans are not patentable in many countries outside Australia and the United States. Moreover, since patent applications are not published until at least 18 months from their first filing date and the publication of ~~discoveries~~disco veries in the scientific literature often lags behind actual discoveries, we cannot be certain that we or any of our licensors were the first creator of inventions covered by pending patent applications or that we or our licensors were the first to file patent applications for such inventions. Additionally, the grant and enforceability of a patent is dependent on a number of factors that may vary between jurisdictions. These factors may include the novelty of the invention, the requirement that the invention not be obvious in the light of prior art (including prior use or publication of the invention), the utility of the invention, and the extent to which the patent clearly describes the best method of working the invention.

While we intend to seek patent protection for our therapeutic products and technologies, we cannot be certain that any of the pending or future patent applications filed by us or on our behalf will be approved, or that we will develop additional proprietary products or processes that are patentable or that we will be able to license any other patentable products or processes. We also cannot be certain that others will not independently develop similar products or processes, duplicate any of the products or processes developed or being developed by us or licensed to us, or design around the patents owned or licensed by us, or that any patents owned or licensed by us will provide us with competitive advantages. Furthermore, we cannot be certain that patents held by third parties will not prevent the commercialization of products incorporating the technology developed by us or licensed to us, or that third parties will not challenge or seek to narrow, invalidate or circumvent any of the issued, pending or future patents owned or licensed by us.

Our commercial success will also depend, in part, on our ability to avoid infringement of patents issued to others. If a court determines that we were infringing any third party patents, we could be required to pay damages, alter our products or processes, obtain licenses or cease certain activities. We cannot be certain that the licenses required under patents held by third parties would be made available on terms acceptable to us or at all. To the extent that we are unable to obtain such licenses, we could be foreclosed from the development, export, manufacture or commercialization of the product requiring such license or encounter delays in product introductions while we attempt to design around such patents, and any of these circumstances could have a material adverse effect on our business, financial condition and results of operations.

We may have to resort to litigation to enforce any patents issued or licensed to us or to determine the scope and validity of third party proprietary rights. Such litigation could result in substantial costs and diversion of effort by us. We may have to participate in opposition proceedings before the Australian Patent and Trademark Office or another foreign patent office, or in interference proceedings declared by the United States Patent and Trademark Office, to determine the priority of invention for patent applications filed by competitors. Any such litigation, interference or opposition proceeding, regardless of outcome, could be expensive and time consuming, and adverse determinations in any such proceedings could prevent us from developing, manufacturing or commercializing our products and could ~~have~~ha ve a material adverse effect on our business, financial condition and results of operations.

In addition to patent protection, we rely on unpatented trade secrets, know-how and other confidential information as well as proprietary technological innovation and expertise that are protected in part by confidentiality and invention assignment agreements with our employees, advisors and consultants.

Patent Portfolio

The following table presents our portfolio of patent and patents applications, including their status and a brief description of the respective inventions.

Patent

Status

Invention

“A method for assaying and treating ~~Alzheimer's Disease"~~ Alzheimer’s Disease”

Filed: November 12, 1992

Applicant: The University of Melbourne

Assigned to Prana Biotechnology Limited

Patents have been granted in Australia, ~~Europe,~~ Japan, Canada and the United ~~States.~~States and validated in certain European countries.

The invention includes claims directed to the use of specified modulators in the treatment of ~~Alzheimer's~~Alzheimer’s disease. Granted European claims include the use of zinc binding agents for oral administration in the treatment of ~~Alzheimer's disease.~~Alzheimer’s Disease.

“Beta amyloid peptide ~~inhibitors"~~ inhibitors”

Filed: July 21, 2000

Applicant: Biomolecular Research Institute and University of Melbourne

Assigned to Prana Biotechnology Limited

~~A patent has~~Patents have been granted in the United States and Australia. Patents in Europe ~~Canada~~ and ~~the United States~~Canada are undergoing ~~examination. Examination~~examination, and examination has been requested in Japan.

The invention encompasses claims to specific classes of agents capable of inhibiting binding of specified metal ions to the N-terminus of beta-amyloid and the use of these agents in the treatment of amyloid related conditions including ~~Alzheimer's~~Alzheimer’s disease.

“Neurotoxic ~~Oligomers"~~ Oligomers”

Filed: June 28, 2000

Applicants: Prana Biotechnology Limited and The General Hospital Corporation

~~A patent has~~Patents have been granted in Australia and New Zealand. A Notice of Allowance has been issued in the United States. ~~An application is~~Applications are under examination in the United States ~~and Europe. Examination has been requested in~~(divisional), Canada, China, Japan and ~~Japan.~~Europe.

The invention is directed to an immunotherapy strategy using tyrosine cross-linked protein aggregates. The approach may be used in the treatment of ~~Alzheimer's~~Alzheimer’s disease and other amyloid related conditions.

~~"Methods of screening for inhibitors of Alzheimer's Disease"~~

“8-Hydroxyquinoline derivatives”

Filed: ~~December 12, 2000 Applicant: The General Hospital Corporation Licensed to Prana Biotechnology Limited~~

~~An application is under examination in the United States.~~

~~The invention encompasses claims to the identification of agents functioning as copper agonists and the use the agents in the treatment of amyloid related conditions including Alzheimer's disease.~~

~~"Treatment of Neurodegenerative Conditions" Filed: April 3,~~July 16, 2003

Applicant: Prana Biotechnology Limited

~~An application~~

Patents in Europe, ~~is pending examination. An application in Hong Kong has been recorded. An application in Australia is under examination. Applications in China and~~ the United States, ~~have lapsed.~~

~~The invention encompasses the utility of the 8-hydroxyquinoline MPAC class in the treatment of neurodegenerative cognitive changes, particularly Huntington's disease.~~

~~Patent~~

~~Status~~

~~Invention~~

~~"8-Hydroxyquinoline derivatives" Filed: July 16, 2003 Applicant: Prana Biotechnology Limited~~

~~Patents have been granted in Europe,~~ New Zealand, Russia, Singapore, Australia, Mexico and South ~~Africa. A Notice of Allowance has~~Africa have been ~~issued in the United States. A patent has been accepted in Australia.~~granted. A patent in Hong Kong has been registered. Applications in India, Japan, Israel, Canada and China are under examination. Examination has been requested in Brazil ~~Japan,~~and South ~~Korea and Canada. Examination is pending in Mexico.~~Korea.

The invention is directed to chemical structures of the ~~8-hydroxyquinoline~~8-Hydroxyquinoline MPAC class and their utility in the treatment of neurological conditions.

“Neurologically-Active ~~Compounds"~~ Compounds”

Filed: October 3 , 2003

Applicant: Prana Biotechnology Limited

~~Applications~~

Patents in the United States, New Zealand, India, Australia, South Africa and Singapore have been granted. Applications in China, Russia, Canada, Europe, ~~Australia~~Japan and Israel are under examination. Examination has been requested in Brazil, ~~Japan,~~ Mexico and South Korea. ~~Applications have been accepted in New Zealand, India, South Africa and Singapore.~~ A patent in Hong Kong has been processed. Divisional applications have been filed in Europe and Japan.

The invention is directed to alternative MPAC chemical structures and their utility in the treatment of neurological conditions.

"Patent	Status	Invention
“Neurologically- Active ~~Compounds"~~ Compounds” Filed: April 1, 2005 Applicant: Prana Biotechnology Limited	~~Applications~~ Patents have been ~~filed~~granted in ~~Australia, Canada, China, Europe, Israel,~~Singapore, Mexico ~~the United States~~ and South ~~Korea.~~Africa. An application in Russia has been accepted. Examination has been requested in Brazil, Canada, India, Israel, Japan ~~India, Brazil,~~and Korea. Applications in Europe, the United States, Australia, New Zealand and ~~Russia. A patent has been granted in Singapore and South Africa.~~China are under examination. A patent in Hong Kong has been processed.	The invention is directed to ~~`F4'~~‘F4’ MPAC chemical structures and their utility in the treatment of neurological conditions.

“Use of ~~Phanquinone~~Clioquinol for the treatment of ~~Alzheimer's Disease"~~ Alzheimer’s Disease”

Filed: ~~October 19, 2000~~ February 13, 1998

Applicant: Prana Biotechnology Limited

Patent has been granted in the United States. ~~A Notice of Allowance has been issued in the United States for a second Patent. An application in Japan is under examination.~~

~~This invention is directed to the use of Phanquinone for the treatment of Alzheimer's disease.~~

~~"Use of Phanquinone for the treatment of memory impairment" Filed: April 3, 2003 Applicant: Prana Biotechnology Limited~~

~~Patent has been granted in the United States. An application in Japan is under examination.~~

~~This invention is directed to the use of Phanquinone for the treatment of age related memory impairment.~~

~~Patent~~

~~Status~~

~~Invention~~

~~"Use of Clioquinol for the treatment of Alzheimer's Disease" Filed: February 13, 1998 Applicant: Prana Biotechnology Limited.~~

~~Patent has been granted in the United States. An application in Japan is under examination.~~

This invention is directed to the use of clioquinol for the treatment of ~~Alzheimer's~~Alzheimer’s disease.

“Pharmaceutical compositions of Clioquinol with B12 for therapeutic ~~use"~~ use”

Filed: February 13, 1998

Applicant: Prana Biotechnology ~~Limited.~~Limited

Patent has been granted in the United States. ~~An application in Japan is under examination.~~

This invention is directed to clioquinol pharmaceutical compositions comprising B12.

“Use of Clioquinol for the treatment of ~~Parkinson's Disease"~~ Parkinson’s Disease”

Filed: February 13, 1998

Applicant: Prana Biotechnology ~~Limited.~~Limited

Patent has been granted in the United States. ~~An application in Japan is under examination.~~

This invention is directed to the use of clioquinol for the treatment of ~~Parkinson's~~Parkinson’s disease.

“Method of treatment and prophylaxis and agents useful for ~~same"~~ same”

Filed: April 13, 2007

Applicant: Prana Biotechnology Limited

An application has been accepted in South Africa. Applications have been filed in Australia, Canada, China, Europe, Israel, New Zealand, the United States, South Korea, ~~South Africa,~~ Japan, India, Brazil and Singapore.

This invention is directed to novel MPAC compounds and compounds for the treatment of age-related macular degeneration.

" “A method of prophylaxis or treatment and agents for ~~same"~~ same”. Filed: June 22, 2007 Applicant: Prana Biotechnology Limited	Applications have been filed in Canada, China, Europe, the USA and Japan. An application in Australia is under examination.	This invention is directed to novel MPAC compounds and compounds for treating certain cancers.
“Compounds for therapy and diagnosis” Filed: December 5, 2008 Applicant: Prana Biotechnology Limited	National phase applications have been filed in Australia, Canada, ~~China,~~New Zealand, Europe, the United States and Japan.	This invention is directed to ~~MPAC~~anti-amyloid (metallo-complexes) compounds for ~~treating certain cancers.~~the treatment of Alzheimer’s disease.

~~"Compounds~~ Patent	Status	Invention
“Processes for ~~therapy and diagnosis"~~ the preparation of 8-hydroxy quinoline derivatives” Filed: December 5,11, 2008 Applicant: Prana Biotechnology Limited	An Australian provisional application has been filed.	This invention is directed to synthetic routes for 8-Hydroxyquinoline derivatives.
“Quinazolinone compounds” Filed: December 24, 2008 Applicant: Prana Biotechnology Limited	A complete international (PCT) application has been filed.	This invention is directed to ~~anti-amyloid (metallo-complexes)~~novel compounds ~~for the treatment of Alzheimer's disease.~~

~~Prior Patents~~

In December 2006, we elected to terminate the license for the following patent which was granted to us under the January 1, 2001 license agreement that we entered into with The General Hospital Corporation of Massachusetts, or GHC, and as result, the patent case was returned to GHC:

—

~~“Use of Clioquinol for the therapy of Alzheimer’s Disease” filed January 4, 1999.~~

In March 2009, we elected to terminate the licenses for the following patents which were granted to us under the January 1, 2001 license agreement that we entered into with GHC, and as result, the applicable patent cases were returned to GHC:

—

~~“An~~~~in vitro~~ ~~system for determining the formation of Ab Amyloid” filed October 19, 1994.~~

—

~~“A diagnostic assay for Alzheimer’s Disease” filed October 19, 1994.~~

—

~~“Identification of agents for use~~and to compounds used in the treatment of ~~Alzheimer’s Disease” filed March 11, 1998.~~Parkinson’s disease.

—

~~“Agents for use in the treatment of Alzheimer’s Disease” filed March 11, 1999.~~

—

~~“Method for Screening drugs useful for treating Alzheimer’s Disease” filed April 29, 1999.~~

—

~~“Methods for the Identification of Agents that Inhibit or Promote Cataracts and Uses thereof” filed August 18, 2000.~~

Patents and License Agreements

On May 7, 1999, we entered into a patent assignment and license agreement with The University of Melbourne. The agreement provided for the assignment to us of various patents and patent rights to us comprised of an international patent application (PCT application) entitled ‘A method of assaying and treating Alzheimer Disease.’ The ~~patent application matured into national phase prosecution in Australia, Canada, Europe, Japan and the United States and selected~~therapeutic claims ~~from this application~~of interest, which have been granted in Europe, Australia and Canada, ~~Europe, Japan and the United States. The invention is~~are directed ~~to a method for assaying for Alzheimer’s disease and~~ to a method for treating the disease by modulating divalent or trivalent cation and/or heparin interaction in a patient with Amyloid Precusor ~~Protein, or APP.~~Protein. The technologies or products that may arise from the invention include therapeutic agents such as zinc binding agents that modulate processing of APP, as well as a screening assay for Alzheimer’s disease to determine the amount of various forms of APP in the circulatory system of a human compared to a control sample to determine presence of the disease.Amyloid Precusor Protein. In consideration of the assignment of the patents, we were required to make certain payments to the University of Melbourne and to pay a royalty of 1.5% on the net price of products sold utilizing such patents. In addition, we were required to pay the lesser of 1.5% of the net invoice price of products sold or 10% of royalties received from any license we granted or sub-licensee we appointed to utilize the patents.

On February 8, 2000, we entered into a patent assignment and intellectual property licensing agreement with The Biomolecular Research Institute, or BRI, under which two patent applications were assigned to us. One is an international patent application (PCT application) entitled ‘Beta-Amyloid Peptide Inhibitors’ which ~~has matured into national phase~~is granted in Australia and in the United States and in prosecution in Canada, Europe ~~Japan~~ and ~~the United States and a patent has been granted in Australia.~~Japan. The invention is directed to compounds which block the metal binding site on Beta-Amyloid. The technologies or products that may arise from this invention include metallo-based compounds as therapeutics or preventative treatments for Alzheimer’s disease. The other patent isentitled ‘Method of Screening for inhibitors of Alzheimer’s Disease,’ an ~~Australian~~Austral ian provisional application ~~which has~~that matured into a patent application in the United States, ~~entitled ‘Method~~was allowed to lapse in the second half of Screening for inhibitors of Alzheimer’s Disease.’ The invention is directed to the use of copper agonist compounds to treat or prevent Alzheimer’s disease. The technologies or products that may arise from this invention include using copper agonists to reduce the processing of APP into beta-amyloid and methods of detecting compounds which can act as copper agonists for use in therapy.2009. In consideration of the assignment of the patents, we are required to pay BRI a royalty of 1.5% on the net invoiced price of products sold utilizing such patents. In addition, we must also pay the lesser of 1.5% of the net invoice price of products sold or 10% of royalties received from any licensee or sub-licensee we appoint to utilize such patents, or a minimum of A$2,000 a year. If the patent rights are assigned before a total of A$20,000 has been paid as royalties, the difference between the royalties paid and A$20,000 must be paid to BRI. To date, we paid a total of $350,000 under the agreement, all of which amount was paid in 2000. On September 10, 2007, we, BRI and the Commonwealth Scientific and Industrial Research Organization, or CSIRO, executed an Assignment and Novation Deed under which BRI assigned to ~~CSIRO~~CSIR O all of its rights and obligations under the patent assignment agreement, including entitlement to royalties.

On January 1, 2001, we entered into a license agreement with GHC, under which we licensed from GHC ~~the patents described below.~~certain patents. The agreement was subsequently amended on August 8, 2001 and March 15, 2004. Under the agreement, as amended, the license for a particular patent expires at the end of the term of the patent rights under the respective patent. In general, the anticipated patent expiration date is 20 years from the filing date of the respective patent application. Under the agreement, we agreed to pay GHC a total of U.S.$166,590 in monthly installments over a 30 month period beginning January 1, 2001 and U.S.$182,000 in monthly installments over a 30 month period beginning August 1, 2001 for the right to use the results of research under the ~~license.~~license agreement. Such obligations have been satisfied by us in full, and we ~~retain~~hold the rights under ~~this~~the license.

—

‘Use of clioquinol for the therapy of Alzheimer’s Disease.’ This patent application was filed on January 4, 1999 in the United States. The patent is expected to expire on January 4, 2019. The invention is directed to the use of Clioquinol as treatment for Azheimer’s disease and the technology is limited to the specific use of Clioquinol as a therapeutic agent. The license provides for potential payments to GHC of an aggregate U.S$1.5 million, in accordance with the following milestones: (i) U.S.$500,000 upon the submission of a registration dossier in the United States or Europe; and (ii) U.S.$1.0 million upon the first approval of a product arising from the invention. The milestones have not been met to date. We terminated the license for this patent and the patent case was returned to GHC in December 2006 after the patent entitled “Use of Clioquinol for the treatment of Alzheimer’s Disease” was assigned to us from P.N. Gerolymatos S.A. pursuant to the terms of the settlement agreement that we entered into on July 28, 2004. For a description of the foregoing settlement agreement see Item 10.C. “Additional Information – Material Contracts.”

—

‘Agents for Use in the treatment of Alzheimer’s Disease.’ This international patent application (PCT application) was filed on March 11, 1999 and matured into national phase prosecution in Australia, Canada, Europe, Hong Kong and the United States. The patent is expected to expire on March 11, 2019. The invention is directed to compositions containing Clioquinol and known metal binding agents and their combined use in the treatment of amyloid related diseases, including Alzheimer’s disease. The technology is limited to the specific use of Clioquinol combined with a metal chelator chosen from one of bathocuproine, bathophenanthroline, DTPA, EDTA, EGTA, penicillamine, TETA or TPEN and pharmaceutical compositions containing such agents. The license provides for potential payments to GHC of an aggregate U.S$1.5 million, in accordance with the following milestones: (i) U.S.$500,000 upon the submission of a registration dossier in the United States or Europe; and (ii) U.S.$1.0 million upon the first approval of a product arising from the invention. The milestones have not been met to date. We terminated the license for this patent and the patent case was returned to GHC as of March 2009.

—

~~‘An~~~~in vitro~~ system for determining formation of Aâ Amyloid.’ This international patent application (PCT application) was filed on October 19, 1994 and matured into national phase prosecution in Canada, Japan and the United States. The patent is expected to expire on October 19, 2014. The invention is directed to an assay for the formation of beta-amyloid in a biological sample and inhibitors of that formation. The technology encompasses various assays for detection of amyloid screening candidate agents for their ability to prevent or reverse the formation of amyloid~~in vitro~~, as well as kits which are used in those methods. One specific product relates to a rapid analytical method for detection amyloid formation in a biological fluid, which involves a series of steps, resulting in a diagnostic. A second product relates to a method for determining whether a compound inhibits the formation amyloid, also by a series of similar steps, i.e. a method for identifying a drug candidate. The license provides for potential payments to GHC of an aggregate U.S$200,000, subject to and upon the first approval of a product arising from the invention. The milestone has not been met to date. We terminated the license for this patent and the patent case was returned to GHC as of March 2009.

—

‘A diagnostic assay for Alzheimer’s Disease.’ This international patent application (PCT application) was filed on October 19, 1994 and matured into national phase prosecution in Canada and the United States. The patent is expected to expire on October 19, 2014. The invention is directed to an antibody based diagnostic assay for the detection and quantification of beta-amyloid species. The technology encompasses various assays and kits for detecting and/or quantifying Abeta in a candidate solution. This assay is based on Abeta strongly binding zinc and copper in a pH dependent manner on a zinc- or copper-treated microwell plate. The assay could be utilized as a diagnostic We currently retain a license under the agreement with GHC for the patent ‘Neurotoxic Oligomers.’ This international patent application (PCT application) was filed on June 28, 2000 and matured into national phase prosecution in Canada, China, Europe, Japan and the United States. Patents have been granted in Australia and New Zealand to both active vaccines and the use of antibodies as a passive vaccine for Alzheimer’s disease. A patent has also been granted in the United States containing claims to an active vaccine and a further divisional patent has been filed in the United States that contains claims to antibodies as a passive vaccine for Alzheimer’s disease. The license provides for potential payments to GHC of an aggregate U.S.$200,000, subject to and upon the first approval of a product arising from the invention. The milestone has not been met to date. We terminated the license for this patent and the patent case was returned to GHC as of March 2009.

—

‘Identification of agents for use in the treatment of Alzheimer’s Disease.’This international patent application (PCT application) was filed on March 11, 1998 and matured into national phase prosecution in the Australia, Canada, Europe, Japan and the United States. The patent is expected to expire on March 11, 2018. The invention is directed to the use of specified metal binding agents to reduce beta-amyloid mediated neurotoxicity and assays to identify agents capable of modifying neurotoxic properties of beta-amyloid. Products arising from the invention include various assays for the identification and administration of agents useful in the treatment of Alzheimer’s disease, as measured by their ability to reduce H2O2 and other free radicals. The technology also includes a method of treating amyloidosis by administering a metal chelator such as bathocuproine, bathophenanthroline, penacillamine, TETA or TPEN. The license provides for potential payments to GHC of an aggregate U.S.$200,000, subject to and upon the first approval of a product arising from the invention. The milestone has not been met to date. We terminated the license for this patent and the patent case was returned to GHC as of March 2009.

—

‘Method of screening for drugs useful in treating Alzheimer’s Disease.’This international patent application (PCT application) was filed on April 29, 1999 and matured into national phase prosecution in Australia, Canada, Europe, Japan and the United States. The patent is expected to expire on April 29, 2019. The invention is primarily directed to specified assays that identify agents capable of modifying the neurotoxic properties of beta-amyloid. The patent and products arising from the invention are substantially related to the patent described immediately above entitled ‘Identification of agents for use in the treatment of Alzheimer’s Disease’and the majority of claims in this case were abandoned in favor of the patent described immediately above. We terminated the license for this patent and the patent case was returned to GHC as of March 2009.

—

‘Neurotoxic Oligomers.’ This international patent application (PCT application) was filed on June 28, 2000 and matured into national phase prosecution in Canada, China, Europe, Japan and the United States. Patents have been granted in Australia and New Zealand. The patent is expected to expire on June 28, 2020. The invention is directed to a novel target for an Alzheimer’s disease vaccine. The technologies or products that may arise from this invention include toxic dimerized full length or fragments of beta-amyloid as active vaccines for Alzheimer’s disease or antibodies to these beta-amyloid fragments as passive vaccines for Alzheimer’s disease. The license provides for potential payments to GHC of an aggregate U.S.$1.5 million, in accordance with the following milestones: (i) U.S.$500,000 upon the submission of a registration dossier ~~in the United States or Europe; and (ii) U.S.$1.0 million upon the first approval of a product arising from the invention. The milestones have not been met to date.~~

—

‘Methods for the identification of Agents that Inhibit or Promote Cataracts and Uses thereof.’ This international patent application (PCT application) was filed on August 18, 2000 and matured into national phase prosecution in Australia, Canada, Europe, Japan and the United States. The patent is expected to expire on August 18, 2020. The invention is directed to assays for the detection of agents useful in the treatment of age-related cataracts and a method of treatment utilizing specified metal chelators. The technologies arising from this invention include various methods for the identification of agents to be used in the treatment of cataracts. In addition, the use of known chelators such as bathocuproine, bathophenanthroline, triethylenetetramine, diethylenetriaminepentaacetic acid, penicillamine, clioquinol and DFO, also derivatives, homologues and analogues. The license provides for potential payments to GHC of an aggregate U.S.$1.5 million, in accordance with the following milestones: (i) U.S.$500,000 upon the submission of a registration dossier in the United States or Europe; and (ii) U.S.$1.0 million upon the first approval of a product arising from the invention. The milestones have not been met to date. We terminated the license for this patent, and the patent case was returned to GHC as of March 2009.

The license agreement with GHC also provides us with the non-exclusive right to use materials, substances and information that were used by GHC in research sponsored by us. In consideration of the license, we are required to pay GHC royalties of 1.5% of the net sales price of products sold utilizing patents exclusively licensed to us. We are also required to pay certain milestone payments upon submission of a registered dossier to a registration authority in the United States or ~~Europe~~Europe; and (ii) U.S.$1.0 million upon the first approval of a product ~~approval in the United States or Europe, to be reduced~~arising from the ~~royalties. In addition, we are obligated~~invention. The milestones have not been met to pay GHC 1.5% of any and all non-royalty payments, including license fees, received from our affiliates. On March 15, 2004, the exclusive license was amended so that we are required to pay GHC the royalties payable to it for any future exploitation of rights to certain U.S. patents relating to PBT1 regardless of the inventorship determination, as required under the settlement agreement among us, P.N. Gerolymatos S.A. and GHC.

date.

Competition

We believe that we will face competition in differing levels of intensity in all of the areas in which we are conducting research. Our competitors in Australia and elsewhere are numerous and include, among others, major pharmaceutical companies, biotechnology firms, universities and other research institutions. These competitors may develop technologies and products that are more effective than any that we are developing, or which would render our technology and products obsolete or non-competitive. Many of these competitors have greater financial, research and screening capabilities, technical resources and manufacturing and marketing capabilities than we do. In addition, many of our competitors have much more experience than we do in pre-clinical testing and human clinical trials of new or ~~improved~~im proved drugs, as well as in obtaining FDA, TGA and other regulatory approvals.

Regulatory Considerations

Our ongoing research and development activities are, and the production and marketing of our pharmaceutical product candidates derived from those activities will be, subject to regulation by numerous governmental authorities in Australia, principally the TGA (Therapeutic Goods Administration), the FDA ~~(Federal~~(the Food and Drug ~~Authority)~~Administration) in the United States, the MHRA (Medicines Control Agency) in the United Kingdom and the EMEA (European Medicines Evaluation Authority). Prior to marketing, any therapeutic product developed must undergo rigorous pre-clinical testing and clinical trials, as well as an extensive regulatory approval process mandated by the TGA and, to the extent that any of our pharmaceutical products under development are marketed abroad, by foreign regulatory agencies, including the FDA, EMEA and MHRA.

Clinical trials are conducted in three sequential phases, but the phases may overlap. Pre-clinical studies involve laboratory evaluation of product characteristics and animal studies to assess the initial efficacy and safety of the product. Clinical trials involve the administration of the investigational product to humans under the supervision of a qualified principal investigator. Phase I clinical trials may be performed in healthy human subjects or, depending on the disease, in patients. The goal of Phase I clinical trials is to establish initial data about the safety, tolerance and pharmacokinetics of the product in humans. In Phase II clinical trials, in addition to safety, the efficacy of the product is evaluated in limited patients with the target disease. Phase III trials typically involve additional testing for safety and clinical efficacy in expanded, large-scale, multi-center studies of patients with the target disease.

Clinical trials can take many years to complete and require the expenditure of substantial resources. The length of time varies substantially according to the type, complexity, novelty and intended use of the product candidate. Delays in obtaining regulatory approvals could adversely affect the development and commercialization of our pharmaceutical product candidates and could have a material adverse impact on our business, financial condition and results of operations.

For details regarding clinical trials for our lead compound PBT2, see Item 4.B. “Information on the Company –- Business Overview –- Clinical Trials for Our Lead Compound.” We cannot make any assurances that we will be able to enter into a collaborative arrangement with a large pharmaceutical or biotechnology company to commercialize PBT2. Nor can we make any assurances that once clinical trials are completed by us or a collaborative partner, we will be able to submit as scheduled a marketing approval request to the applicable governmental regulatory authority, or that such request and application will be reviewed and cleared by such governmental authority in a timely manner, or at all. Although we intend to make use of fast-track and abbreviated regulatory approval programs when possible and ~~commercially~~com mercially appropriate, we cannot be certain that we will be able to obtain the clearances and approvals necessary for clinical testing or for manufacturing and marketing our pharmaceutical products candidates.

During the course of clinical trials and toxicology studies, product candidates may exhibit unforeseen and unacceptable drug-related toxicities or side effects. If any unacceptable toxicities or side effects were to occur, we may, or regulatory authorities may require us to, interrupt, limit, delay or abort the development of our potential products. In addition, unacceptable toxicities could ultimately prevent the clearance of our product candidates by the TGA, EMEA, FDA or other regulatory authority for any or all targeted indications. Even after being cleared by a regulatory authority, any of our products may later be shown to be unsafe or not to have its purported effect, thereby preventing widespread use or requiring withdrawal from the market. We cannot make any assurances that PBT2 or any other development or product candidate will be safe or effective when administered to patients.

Historical Collaborative Efforts

In August 2003, utilizing the grant we received from the Commonwealth Government of Australia under the Biotechnology Innovation Fund, or BIF, we entered into an agreement with Prima Biotechnology Limited, or Prima, through its collaborative research partner, the Macfarlane Burnet Institute for Medical Research and Public Health, known as the Burnet Research Institute at Austin, together with the University of Melbourne and the Mental Health Research Institute, to undertake proof of concept research for our prospective Alzheimer’s disease vaccine target. This collaboration enabled us to access Prima’s adjuvant vaccine technology, known as DCtag, in the design of candidate vaccine fragments. Under the terms of our contractual relationship with Prima, we retained all intellectual property rights to our ~~monoclonal~~mon oclonal antibodies that were used for the collaboration. Under the terms of the agreement, we are required to pay Prima royalties equal to 5% of any income that we may receive upon commercialization of the monoclonal antibodies. In May 2006, we terminated our collaboration with Prima due to a delay in reaching certain milestones, subject to our surviving obligation to pay royalties. The scientists who worked on the project on behalf of Prima have since been hired by Monash University, and we have retained their services to characterize selective monoclonal antibodies under a research agreement that we entered into with Monash University in January 2007.

Manufacturing and Raw Materials

We have used third party manufacturers to produce the primary drug product (API) and secondary drug forms for our large-scale, pre-clinical and clinical PBT2 trials, and we expect that we will use third party manufacturers for any future product candidates. We cannot make any assurances that we will be able to manufacture sufficient quantities of PBT2 or any other development or product candidate in a cost-effective or timely manner. Any delays in production would delay our pre-clinical and human clinical trials, which could have a material adverse effect on our business, financial condition and results of operations. We also cannot make any assurances that we will be able to enter into collaborative or contracting arrangements on acceptable terms with third party manufacturers that will meet our ~~requirements~~requirem ents for quality, quantity and timeliness.

We expect that we will be required to design and develop new synthetic pathways for most, if not all, of the products that we currently intend to develop or may develop in the future. We cannot predict the success of such efforts, the purity of the products that may be obtained or the nature of the impurities that may result from such efforts. If we are not able to obtain an acceptable purity for any product candidate or an acceptable impurity profile, pre-clinical and clinical trials would be delayed, which could have a material adverse effect on the priority of the development of our product candidates, our business, financial condition and results of operations. We cannot guarantee that it will be possible to scale up new synthetic processes to provide sufficient API for clinical drug trials, which ~~could~~cou ld indefinitely delay the initiation of clinical trials utilizing API.

C.	~~ORGANIZATIONAL STRUCTURE~~Organizational Structure

~~In August 2004, we established~~

Our two wholly owned subsidiaries, Prana Biotechnology Inc., incorporated in the United States, and Prana Biotechnology UK plc, incorporated in the United Kingdom. Prana Biotechnology Inc. was established in the United States due to the increase in our U.S. operations and U.S. investors in our company at such time. Prana Biotechnology UK plc was established in the United Kingdom, ~~to allow us to conduct commercial and clinical operations in the United Kingdom. Both of the subsidiaries~~ are currently inactive.

D.	~~PROPERTY, PLANTS AND EQUIPMENT~~Property, Plants and Equipment

Our executive offices are located at 369 Royal Parade, Parkville, Victoria 3052, Australia, where we occupy approximately 3,800 square feet. The lease for the office space, which expires on October 31, 2010, has an annual rental of A$~~108,693 for the period through October 31, 2009 and A$~~114,901 for the period through October 31, 2010.

We have exercised our option to extend the lease for an additional 12 months, at an annual rent of approximately A$104,761.

We own computer equipment, office furniture and laboratory ~~equipment, the major item being a mass spectrometer that is being used at the University of Melbourne.~~

equipment.

ITEM 4A. UNRESOLVED STAFF COMMENTS

Not applicable.

~~ITEM 4A.~~

~~UNRESOLVED STAFF COMMENTS~~

~~Not applicable.~~

ITEM 5.

OPERATING AND FINANCIAL REVIEW AND PROSPECTS

The following discussion and analysis includes certain forward-looking statements with respect to the business, financial condition and results of operations of our company. The words ~~“estimate,” “project,~~"estimate," "project,” “intend,~~” “expect”~~" "expect" and similar expressions are intended to identify forward-looking statements within the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those contemplated by such forward-looking statements, including those risk factors contained in Item 3.D. of this annual report. You should read the following discussion and analysis in conjunction with our consolidated financial statements and the notes thereto included in this annual ~~report.~~

rep ort.

A.	~~OPERATING RESULTS~~Operating Results

Background

We were incorporated under the laws of the Commonwealth of Australia on November 11, 1997. Our mission is to develop therapeutic drugs designed to treat the underlying cause of degeneration of the brain and the eye as the aging process progresses. The principal listing of our ordinary shares and listed options to purchase our ordinary shares is on the Australian Stock Exchange, or ASX. Since September 5, 2002, our American Depository Receipts, or ADRs, have traded on the NASDAQ Capital Market under the symbol “PRAN.” We have two wholly-owned subsidiaries, Prana Biotechnology Inc. and Prana Biotechnology UK Limited, incorporated in the United States and the United Kingdom, respectively, in August 2004, both of which are currently inactive.

Our consolidated financial statements appearing in this annual report are prepared in Australian dollars and in accordance with IFRS as issued by IASB, which became effective for our company as of our fiscal year ended June 30, 2006. Our consolidated financial statements appearing in this annual report comply with both IFRS as issued by IASB and A-IFRS. In this annual report, all references to “U.S. dollars” or “US$” are to the currency of the United States of America, and all references to “Australian dollars” or “A$” are to the currency of Australia.

All of our revenues are generated in Australian dollars, except for interest earned on foreign currency bank accounts, and the majority of our expenses are incurred in Australian dollars.

Overview

We are a development stage enterprise at an early stage in the development of our pharmaceutical products that are designed to treat the underlying causes of degeneration of the brain and the eye as aging progresses. We have incurred net losses since inception and expect to incur substantial and increasing losses for the next several years as we expand our research and development activities and move our product candidates into later stages of development. All of our product candidates are in early stages of development and we face the risks of failure inherent in developing drugs based on new technologies. The process of carrying out the development of our products to later stages of development may require significant additional research and development expenditures, including pre-clinical testing and ~~clinical~~c linical trials, as well as for obtaining regulatory approval. To date, we have funded our operations primarily through the sale of equity securities, proceeds from the exercise of options, government grants, licensing and research collaborations and interest income.

Since completing our initial public offering and listing process on the ASX on March 28, 2000, we have concentrated our resources toward the pursuit of our disease targets. Initially we focused on clinical trials of our PBT1 compound as a therapeutic for the treatment of Alzheimer’s disease, which we ceased in April 2005 due to an unacceptably high level of an impurity found in the compound. In early August 2003, our PBT2 compound was announced as a new lead metal protein attenuating compound, or MPAC, molecule for Alzheimer’s disease. We have completed two Phase I studies of PBT2 and a Phase IIa clinical trial for PBT2 in patients with Alzheimer’s ~~disease.For~~disease. For details regarding clinical trials for our lead compound PBT2, see Item 4.B. “Information on the Company ~~– Business~~- Busin ess Overview –- Clinical Trials for Our Lead Compound.”

Critical Accounting Policies

We prepare our financial statements in accordance with IFRS as issued by IASB. As such, we are required to make certain estimates, judgments, and assumptions that management believes are reasonable based upon the information available. These estimates, judgments and assumptions affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the periods presented. The significant accounting policies listed in Note 1 to the consolidated financial statements that management believes are the most critical to aid in fully understanding and evaluating our financial condition and results of operations under IFRS are discussed below.

Share-based payments.Equity-settled share-based payments granted after November 7, 2002 that were unvested as of January 1, 2005 are measured at fair value at the date of grant. Fair value is measured by use of the Black-Scholes model (for options without market conditions) or the Barrier Pricing model (for options with market conditions). The expected life used in the model has been adjusted, based on management’s best estimate, for the effects of non-transferability, exercise restrictions, and behavioural considerations. The date used to value share-based payments for non-employees may be different to the grant date used to value employee share-based payments where service conditions apply. The fair value of the ~~equity-settled~~equity - -settled share-based payments is expensed on a straight-line basis over the vesting period for each tranche of equity, based on our estimate of equity that will eventually vest.

Revenue recognition from continuing operations. We recognize revenue from continuing operations to the extent that it is probable that the economic benefits will flow to us and the revenue from continuing operations can be reliably measured. To date our revenue from continuing operations has consisted of interest income, which is recognized as earned when collectibility is reasonably assured.

Other income recognition. We recognize other income to the extent that it is probable that the economic benefits will flow to us and the other income can be reliably measured. Reimbursements of expenses are recognized as ~~income when~~an offset of the ~~reimbursement is received and~~expense (see Note 4a to the ~~related expenses have been incurred.~~consolidated financial statements).

Recoverable amount of non-current assets. Each reporting period, our Board of Directors assesses the recoverable amount of all non-current assets to ensure its carrying value does not exceed its recoverable amount. Where the carrying amount of a non-current asset is greater than its recoverable amount, the asset is revalued down to its recoverable amount. Recoverable amount is the higher of fair value less costs to sell and value in use. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset for which the estimates of future cash flows have not been adjusted.

Significant Costs and Expenses

Research and development expenses, net. Our research and development expenses consist primarily of ~~compensation and related costs for~~ expenses for ~~testing facilities~~contracted research and ~~payments under~~development activities conducted by third parties on our ~~research, pre-clinical and clinical developmental agreements.~~behalf. Research and development expenses also include costs associated with the acquisition and development of ~~patents, which have been expensed subsequent to December 1999.~~patents.

Personnel expenses. Our personnel expenses consist of directors’ fees, consultancy fees paid to clinicians and scientists, salaries and benefits paid to employees and officers, and equity-based payments awarded to directors, officers and employees. Personnel expenses include salaries and fees paid to employees and consultants involved in research and development activities.

Intellectual property expenses. Our intellectual property expenses consist of fees paid to our outside counsel for legal fees associated with patent applications and for the defense of patents.

Auditor and accounting expenses.Our auditor and accounting expenses consist of the fees paid to our auditors for services related to annual reports and interim reports filed or submitted in Australia and the United States and fees paid to other accounting firms in respect of tax and other accounting advice.

Travel expenses.Our travel expenses consist primarily of expenses associated with air travel, accommodation and associated consumables both locally and overseas by directors, employees and consultants.

Public relations and marketing expenses.Our public relations and marketing expenses consist of fees paid to outside consultants for services related to ASX and NASDAQ announcements and presentations.

Depreciation expense. Depreciation of property and equipment is provided on a straight-line basis over the estimated useful lives of three to 20 years.






—	· Furniture and fittings:	~~5-33~~	%5-33%
—	· Computer equipment:	33	%33%
—	· Laboratory equipment:	~~10-33~~	%10-33%
—	· Leasehold improvements:	33	%33%

Other expenses. Other expenses consist of corporate compliance, insurance, computer and overhead expenses.

Foreign exchange gain (loss). Foreign exchange gain (loss) includes the net unrealized gain or loss on cash balances held in foreign currencies (primarily U.S. dollars, British Pounds and Euros) as well as net realized gains and losses on foreign currency transactions.

Gain (loss) on fair value of financial liabilities. Each reporting period we are required to revalue financial liabilities. We recorded financial liabilities attributable to warrants that were issued to the investors in our private placement in the United States in June 2004. The warrants, which expired on June 4, 2009, permitted the investors to purchase an aggregate 3,000,000 ADRs at an exercise price of US$8.00 per ADR. Because the warrants were exercisable in a currency that is not the functional currency of our company, they are required to be classified as a financial liability. When the fair value of the outstanding warrants increased or decreased, the difference was recorded as a gain or loss, as applicable, on the fair value of financial ~~liabilities.The~~liabilities. The warrants expired without being exercised.

Results of Operations

Year ended June 30, 2010 compared to year ended June 30, 2009

Revenue from continuing operations

Revenue from continuing operations decreased to A$215,008 for the year ended June 30, 2010 from A$428,193 for the year ended June 30, 2009, a decrease of A$213,185, or 49.79%. Revenue from continuing operations consisted of A$215,008 and A$428,154 in interest income for the years ended June 30, 2010 and 2009, respectively. The decrease in revenue from continuing operations in the 2010 fiscal year is primarily attributable to lower interest income as a result of a reduction in cash and cash equivalents and lower prevailing interest rates.

Other Income

We did not have other income for the years ended June 30, 2010 and 2009.

Research and development expenses, net

Our net research and development expenses (including research and development expenses paid to related parties) decreased to A$87,992 for the year ended June 30, 2010 from A$2,215,358 for the year ended June 30, 2009, a decrease of A$2,127,366, or 96.03%. For the year ended June 30, 2010, we incurred research and development expenses of A$2,340,377 (including research and development expenses paid to related parties), which amount was offset by a A$2,252,385 one-time reimbursement that we received in connection with a research and development contract that we had previously entered into with Quintiles. We anticipate that in fiscal year 2011, our research and development expenditure will be primarily directed at possible Phase II studies of PBT2 for the tre atment of Alzheimer’s disease and/or Huntington’s disease. In addition, we also intend to investigate lead MPAC candidate compounds for Parkinson’s disease and brain cancer models and the effect of our monoclonal antibody in models of Alzheimer’s disease.

Personnel expenses

Personnel expenses decreased to A$3,087,234 for the year ended June 30, 2010 from A$3,832,804 for the year ended June 30, 2009, a decrease of A$745,570, or 19.45%. The decrease in personnel expenses in the 2010 fiscal year is primarily attributable to decreased equity-based compensation in the form of options and shares issued to directors, employees and consultants. In the 2010 fiscal year, we expensed A$730,480 in respect of equity-based payments to directors, consultants and employees compared to A$1,305,471 in the 2009 fiscal year. Personnel expenses in the 2010 and 2009 fiscal years include a portion of the total fair value of options granted to our directors and employees in the previous fiscal years of A$214,952 and A$516,432, respectively. The decrease in personnel expense in the 2010 f iscal year is also due to a decrease in consulting and director fees for such period.

Intellectual property expenses

Intellectual property expenses, which include patent portfolio costs and intellectual property related legal costs, decreased to A$431,082 for the year ended June 30, 2010 from A$1,107,534 for the year ended June 30, 2009, a decrease of A$676,452, or 61.08%. The decrease in intellectual property expenses in the 2010 fiscal year was primarily due to substantially reduced intellectual licensing activity in such period. In addition, patent portfolio costs decreased to A$426,105 in the 2010 fiscal year from A$628,865 in the 2009 fiscal year, primarily due to the completion of prosecution of key patents in Europe and Japan during the 2009 fiscal year.

Auditor and accounting expenses

Auditor and accounting expenses increased to A$168,909 for the year ended June 30, 2010 from A$129,998 for the year ended June 30, 2009, an increase of A$38,911, or 29.93%. The increase in auditor and accounting expenses in the 2010 fiscal year is primarily attributable to an increase in auditor fees resulting from increased market rates and costs associated with preparation for the expected auditor attestation report on our internal control over financial reporting, which requirements no longer applies to our company .

Travel expenses

Travel expenses increased to A$234,555 for the year ended June 30, 2010 from A$195,251 for the year ended June 30, 2009, an increase of A$39,304, or 20.13%. The increase in travel expenses in the 2010 fiscal year is primarily attributable to increased overseas travel by executives and consultants for activities associated with Phase II studies for PBT2.

Public relations and marketing expenses

Public relations and marketing expenses decreased to A$130,090 for the year ended June 30, 2010 from A$222,679 for the year ended June 30, 2009, a decrease of A$92,589, or 41.58%. Our public relations and marketing expenses consist primarily of costs relating to our U.S.-based investor relations consultants. The decrease in public relations and marketing expenses in the 2010 fiscal year is primarily attributable to a decrease in public relations consultant fees, together with the appreciation of the Australian dollar against the U.S. dollar during the 2010 fiscal year, which decreased the Australian dollar value of such U.S. dollar denominated expenses.

Depreciation expenses

Depreciation expenses increased to A$35,290 for the year ended June 30, 2010 from A$34,190 for the year ended June 30, 2009, an increase of A$1,100, or 3.2%. The increase in depreciation expenses in the 2010 fiscal year is primarily attributable to additional plant and computer equipment in the aggregate amount of A$22,665 that we purchased during the 2010 fiscal year.

Other expenses

Other expenses decreased to A$940,699 for the year ended June 30, 2010 from A$978,875 for the year ended June 30, 2009, 2008, a decrease of A$38,176, or 3.9%. The decrease in other expenses in the 2010 fiscal year is primarily attributable to a decrease in insurance and office costs.

Foreign exchange gain (loss)

We recorded a foreign exchange loss of A$6,079 for the year ended June 30, 2010 compared to a foreign exchange loss of A$6,723 for the year ended June 30, 2009. Foreign exchange gain (loss) reflects the impact of changes in foreign currency exchange rates on cash that we hold in U.S. dollars, Great British Pounds and Euro. In the 2010 fiscal year, the Australian dollar appreciated against the U.S. dollar, while in the 2009 fiscal year the Australian dollar depreciated against the U.S. dollar. In fiscal 2010, we incurred a foreign exchange gain of A$38,584 attributable to the cash balances that we held in U.S. dollars, a foreign exchange loss of A$108 attributable to the cash balances that were held in British Pounds, a foreign exchange loss of A$40,492 attributable to cash balances that were held in Euros and a foreign exchange loss of A$4,063 attributable to foreign currency transactions. In fiscal 2009, we incurred a foreign exchange gain of A$5,536 attributable to the cash balances that we held in U.S. dollars, a foreign exchange gain of A$5,893 attributable to the cash balances that were held in British Pounds, a foreign exchange gain of A$4,072 attributable to cash balances that were held in Euros and a foreign exchange loss of A$22,224 attributable to foreign currency transactions.

Gain (loss) on fair value of financial liabilities

We did not record a gain or loss on fair valuation of financial liabilities for 2010 fiscal year. We recorded a gain on fair value of financial liabilities of A$772,430 for the year ended June 30, 2009 attributable to the warrants that were issued in connection with our private placement of securities in the United States in June 2004 that expired on June 4, 2009. The gain and loss on fair value of financial liabilities is attributable to the changes in the market price of our ADRs and the volatility of the ADR market price.

Year ended June 30, 2009 compared to year ended June 30, 2008

Revenue from continuing operations

Revenue from continuing operations decreased to A$428,154 for the year ended June 30, 2009 from A$490,943 for the year ended June 30, 2008, a decrease of A$62,789, or 13%. Revenue from continuing operations consisted of A$428,154 and A$490,943 in interest income for the years ended June 30, 2009 and 2008, respectively. The decrease in revenue from continuing operations in the 2009 fiscal year is primarily attributable to lower interest income as a result of a reduction in cash and cash equivalents.

Other Income

We did not have other income for the year ended June 30, 2009. We had other income of A$170 for the year ended June 30, 2008.

Research and development expenses,

net

Research and development expenses, net (including research and development expenses paid to related parties) decreased to A$2,215,358 for the year ended June 30, 2009 from A$5,757,168 for the year ended June 30, 2008, a decrease of A$3,541,810, or 62%. The decrease in research and development expenses, net in the 2009 fiscal year is primarily attributable to most costs associated with the Phase IIa clinical trial being expended in the 2008 fiscal year. The trial commenced in December 2006 and was completed in February 2008. We anticipate that in fiscal year 2010, our research and development expenditure will be primarily directed at possible Phase II studies of PBT2 for the treatment of Alzheimer’s disease and Huntington’s disease. In addition, we also intend to investigate lead MPAC candidate compounds for Parkinson’s disease and brain cancer models, the effect of our monoclonal antibody in models of Alzheimer’s disease, and the behavior of our metal-based amyloid binding compounds as amyloid imaging agents.

Personnel expenses

Personnel expenses decreased to A$3,832,804 for the year ended June 30, 2009 from A$5,350,189 for the year ended June 30, 2008, a decrease of A$1,517,385, or 28%. The decrease in personnel expenses in the 2009 fiscal year is primarily attributable to decreased equity-based compensation in the form of options and shares issued to directors, employees and consultants. In the 2009 fiscal year, we expensed A$1,305,471 in respect of equity-based payments to directors, consultants and employees compared to A$2,237,421 in the 2008 fiscal year. Personnel expenses in the 2009 and 2008 fiscal years include a portion of the total fair value of options granted to our directors and employees in the previous fiscal years of A$516,432 and A$420,343, respectively. The decrease in personnel expense in the 2009 fiscal year is also due to a decrease in consulting and director fees for such period.

Intellectual property expenses

Intellectual property expenses increased to A$1,107,534 for the year ended June 30, 2009 from A$469,428 for the year ended June 30, 2008, ~~anincreaseof~~an increase of A$638,106, or 136%. The ~~increasein~~increase in intellectual property expenses in the 2009 fiscal year was due to two international (PCT) patent applications maturing into numerous national phase patent office filings globally and continuing patent prosecution ~~forour~~for our MPAC chemistry patent cases, including the 8-hydroxyquinoline patent case and immunotherapy patent case, which are in advanced patent prosecution stages. In addition, in ~~2009~~200 9 we incurred increased legal expenses in connection with the potential licensing of our MPAC assets.

Auditor and accounting expenses

Auditor and accounting expenses decreased to A$129,998 for the year ended June 30, 2009 from A$331,950 for the year ended June 30, 2008, a decrease of A$201,952, or 61%. The decrease in auditor and accounting expenses in the 2009 fiscal year is primarily attributable to additional auditor fees incurred during the 2008 fiscal year in connection with a Securities and Exchange Commission, or SEC, review of our annual report on Form 20-F for the fiscal year ended June 30, 2006 and responding to the comments of the SEC staff. In addition, we renegotiated our independent auditor’s fees for the 2009 fiscal year, resulting in a $A70,000 decrease in audit fees compared to the 2008 fiscal year audit.

Travel expenses

Travel expenses increased to A$195,251 for the year ended June 30, 2009 from A$146,651 for the year ended June 30, 2008, an increase of A$48,600, or 33%. The increase in travel expenses in the 2009 fiscal year is primarily attributable to increased overseas travel by executives for company business meetings and by executives and consultants in connection with their attendance at the International Conference on Alzheimer’s Disease (ICAD) in July 2008.

Public relations and marketing expenses

Public relations and marketing expenses increased to A$222,679 for the year ended June 30, 2009 from A$141,337 for the year ended June 30, 2008, an increase of A$81,342, or 58%. Our public relations and marketing expenses consist primarily of costs relating to our U.S.-based investor relations consultants. The increase in public relations and marketing expenses in the 2009 fiscal year is primarily attributable to an increase in the fees paid to our U.S.-based investor relations consultants.

Depreciation expenses

Depreciation expenses increased to A$34,190 for the year ended June 30, 2009 from A$25,349 for the year ended June 30, 2008, an increase of A$8,841, or 35%. The increase in depreciation expenses in the 2009 fiscal year is primarily attributable to additional computer equipment in the aggregate amount of A$31,474 that we purchased during the 2009 fiscal year combined with the acceleration of depreciation for obsolete computer equipment.

Other expenses

Other expenses (including other expenses paid to related parties) increased to A$978,757 for the year ended June 30, 2009 from A$975,404 for the year ended June 30, 2008, an increase of A$3,353, or 0.3%. The increase in other expenses in the 2009 fiscal year is primarily attributable to an increase in corporate compliance costs as a result of increased legal fees.

Foreign exchange gain (loss)

We recorded a foreign exchange loss of A$6,723 for the year ended June 30, 2009 compared to a foreign exchange loss of A$402,886 for the year ended June 30, 2008. In the 2009 fiscal year, the Australian dollar appreciated against the U.S. dollar, while the Australian dollar depreciated against the U.S. dollar in the 2008 fiscal year. In fiscal 2009, we incurred a foreign exchange gain of A$5,536 attributable to the cash balances that we held in U.S. dollars, a foreign exchange gain of A$5,893 attributable to the cash balances that were held in British Pounds, a foreign exchange gain of A$4,072 attributable to cash balances that were held in Euros and a foreign exchange loss of A$21,654 attributable to foreign currency transactions. In fiscal 2008, we incurred a foreign exchange loss of A$425,794 ~~attributable~~attributa ble to the cash balances that we held in U.S. dollars, a foreign exchange loss of A$8,726 attributable to the cash balances that were held in British Pounds, a foreign exchange loss of A$508 attributable to cash balances that were held in Euros and a foreign exchange gain of A$31,466 attributable to foreign currency transactions.

Gain (loss) on fair value of financial liabilities

We recorded a gain on fair value of financial liabilities of A$772,430 for the year ended June 30, 2009 compared to a loss on fair value of financial liabilities of A$451,429 for the year ended June 30, 2008, attributable to the warrants that were issued in connection with our private placement of securities in the United States in June 2004 that expired on June 4, 2009. The gain and loss on fair value of financial liabilities is attributable to the changes in the market price of our ADRs and the volatility of the ADR market price.

Year ended June 30, 2008 compared to year ended June 30, 2007

~~Revenue from continuing operations~~

Revenue from continuing operations decreased to A$490,943 for the year ended June 30, 2008 from A$507,150 for the year ended June 30, 2007, a decease of A$16,207, or 3%. Revenue from continuing operations consisted of A$490,943 and A$507,150 in interest income in the years ended June 30, 2008 and 2007, respectively. The decrease in revenue from continuing operations in the 2008 fiscal year was primarily attributable to lower interest income as a result of fluctuations of cash and cash equivalents held during the year.

~~Other Income~~

~~Other income decreased to A$170 for the year ended June 30, 2008 from A$287 for the year ended June 30, 2007, a decrease of A$117, or 41%.~~

~~Research and development expenses~~

Research and development expenses (including research and development expenses paid to related parties) increased to A$5,757,168 for the year ended June 30, 2008 from A$4,492,193 for the year ended June 30, 2007, an increase of A$1,264,975, or 28%. The increase in research and development expenses in the year ended June 30, 2008 was primarily attributable to the increased costs associated with the Phase IIa clinical trial. The trial commenced in December 2006 and was completed in February 2008 and the majority of expenditure related to the trial was incurred in the latter part of the trial. Additional expenditure was also incurred in respect of drug discovery.

~~Personnel expenses~~

Personnel expenses increased to A$5,350,189 for the year ended June 30, 2008 from A$4,554,731 for the year ended June 30, 2007, an increase of A$795,458, or 18%. The increase in personnel expenses in the 2008 fiscal year was primarily attributable to increased equity-based compensation in the form of options and shares granted to directors and consultants. In the 2008 fiscal year we expensed A$2,237,421 in respect of equity-based payments to directors, consultants and employees compared to A$1,386,243 in the 2007 fiscal year. Personnel expenses in the 2008 and 2007 fiscal year include a portion of the total fair value of options granted to our directors and employees in the previous fiscal years of A$420,343 and A$192,890, respectively. In addition, in January 2008 employee salaries increased as part of staff reviews.

~~Intellectual property expenses~~

Intellectual property expenses decreased to A$469,428 for the year ended June 30, 2008 from A$600,232 for the year ended June 30, 2007, a decease of A$130,804, or 22%. The decrease in intellectual property expenses in the 2008 fiscal year was primarily due to increased patent attorney expenses that we incurred in fiscal year 2007 in respect of patents.

~~Auditor and accounting expenses~~

Auditor and accounting expenses increased to A$331,950 for the year ended June 30, 2008 from A$260,117 for the year ended June 30, 2007, an increase of A$71,833, or 28%. The increase in auditor and accounting expenses in the 2008 fiscal year was attributable to additional auditor fees incurred in connection with a Securities and Exchange Commission review of our annual report on Form 20-F for the fiscal year ended June 30, 2006 and an amendment to our annual report on Form 20-F for such period. Additional auditor fees were also incurred in fiscal year 2008 as a result of replacing our previous independent registered public accountants.

~~Travel expenses~~

Travel expenses decreased to A$146,651 for the year ended June 30, 2008 from A$309,997 for the year ended June 30, 2007, a decease of A$163,346, or 53%. The decrease in travel expenses in the 2008 fiscal year was primarily attributable to decreased overseas business travel for directors, executives and consultants, among other things, as a result of a reduced number of Research and Development Advisory Board meetings.

~~Public relations and marketing expenses~~

Public relations and marketing expenses decreased to A$141,337 for the year ended June 30, 2008 from A$215,455 for the year ended June 30, 2007, a decease of A$74,118, or 34%. The decrease in public relations and marketing expenses in the 2008 fiscal year was primarily attributable to a reduction in expenses paid to consultants due to reduced consulting services received in such period.

~~Depreciation expenses~~

Depreciation expenses decreased to A$25,349 for the year ended June 30, 2008 from A$58,582 for the year ended June 30, 2007, a decease of A$33,233, or 57%. The decrease in depreciation expenses in the 2008 fiscal year was primarily attributable to fixed assets being fully depreciated in fiscal year 2007.

~~Other expenses~~

Other expenses (including other expenses paid to related parties) decreased to A$975,404 for the year ended June 30, 2008 from A$1,008,563 for the year ended June 30, 2007, a decease of A$33,159, or 3%. The decrease in other expenses in the 2008 fiscal year was attributable to a reduction in corporate compliance costs as a result of reduced legal costs and costs associated with the printing and distribution of our Annual Reports which are now made available to shareholders electronically. Lease expenses increased following a new lease agreement being signed, however insurance expenditure reduced as a result of more competitive premiums.

~~Foreign exchange gain (loss)~~

We recorded a foreign exchange loss of A$402,886 for the year ended June 30, 2008 compared to a foreign exchange loss of A$757,578 for the year ended June 30, 2007. In fiscal 2008, we incurred a foreign exchange loss of $425,794 attributable to the cash balances that we held in U.S. dollars, a foreign exchange loss of A$8,726 attributable to the cash balances that were held in British Pounds, a foreign exchange loss of A$508 attributable to cash balances that were held in Euros and a foreign exchange loss of A$31,466 attributable to foreign currency transactions. In fiscal 2007, we incurred a foreign exchange loss of $763,797 attributable to the cash balances that we held in U.S. dollars, a foreign exchange loss of A$6,499 attributable to the cash balances that were held in British Pounds, a foreign exchange loss of A$7,839 attributable to cash balances that were held in Euros and a foreign exchange gain of A$20,554 attributable to foreign currency transactions.

~~Gain (loss) on fair value of financial liabilities~~

We recorded a loss on fair value of financial liabilities of A$451,429 for the year ended June 30, 2008 compared to a gain of A$607,691 for the year ended June 30, 2007 attributable to the warrants that were issued in connection with our private placement of securities in the United States in June 2004. The gain and loss on fair value of financial liabilities is attributable to the changes in the market price of our ADRs and the volatility of the ADR market price.

Inflation and Seasonality

Management believes inflation has not had a material impact on our company’s operations or financial condition and that our operations are not currently subject to seasonal influences.

Conditions in Australia

We are incorporated under the laws of, and our principal offices and research and development facilities are located in, the Commonwealth of Australia. Therefore, we are directly affected by political and economic conditions in Australia.

Recently Issued International Accounting Standards and Pronouncements

Certain new ~~International~~ accounting standards and interpretations have been published that are not mandatory for June 30, ~~2009~~2010 reporting periods. ~~Based on our~~Our assessment ~~we believe that~~of the ~~following~~impact of these new standards and interpretations ~~could~~is described below.

IFRS 2009-8 Amendments to International Accounting Standards – Group Cash-Settled Share-Based Payment Transactions [IFRS 2] (effective for all accounting periods commencing on or after January 1, 2010). The amendments made by the IASC to IFRS 2 confirm that an entity receiving goods or services in a group share-based payment arrangement must recognize an expense for those goods or services regardless of which entity in the ~~future~~group settles the transaction or whether the transaction is settled in shares or cash. They also clarify how the group share-based payment arrangement should be measured, that is, whether it is measured as an equity- or a cash-settled transaction. We will apply these amendments retrospectively for the financial reporting per iod commencing on July 1, 2010. We do not expect the adoption of these amendments to have an impact on our consolidated financial statements.

~~IAS 23 (Amendment), “Borrowing costs”~~IFRS 2009-10 Amendments to International Accounting Standards – Classification of Rights Issues [IAS 32] (effective for ~~annual~~all accounting periods commencing on or after 1 February 2010). In October 2009, the IASC issued an amendment to IAS 32 Financial Instruments: Presentation, which addresses the accounting for rights issues that are denominated in a currency other than the functional currency of the issuer. Provided certain conditions are met, such rights issues are now classified as equity regardless of the currency in which the exercise price is denominated. Previously, these issues had to be accounted for as derivative liabilities. The amendment must be applied retrospectively in accordance with IAS 8 Accounting Policies, Changes in Accounting Estimates and Errors. We will apply the amended standard from July 1, 2010. As we have not made any such rights issues, the amendment will not have any effect on our consolidated financial statements.

IFRS 7 Financial Instruments and IFRS 2009-11 Amendments to International Accounting Standards arising from IFRS 7 (effective from 1 January 2013). IFRS 7 Financial Instruments addresses the classification and measurement of financial assets and is likely to affect our accounting for our financial assets. The standard is not applicable until January 1, 2013, but is available for early adoption. We are yet to assess its full impact. However, initial indications are that it may affect our accounting for our available-for-sale financial assets, since IFRS 7 only permits the recognition of fair value gains and losses in other comprehensive income if they relate to equity investments that are not held for trading. Fair value gains a nd losses on available-for-sale debt investments, for example, will therefore have to be recognized directly in profit or loss. For the year ended June 30, 2010, we did not recognize any such gains or losses in other comprehensive income. We have not yet decided when to adopt IFRS 7.

Revised IAS 24 Related Party Disclosures and IFRS 2009-12 Amendments to International Accounting Standards (effective from 1 January 2011). In December 2009, the IASC issued a revised IAS 24 Related Party Disclosures. It is effective for accounting periods beginning on or after January 1, ~~2009~~2011 and ~~applicable~~must be applied retrospectively. The amendment removes the requirement for government-related entities to ~~our company effective~~disclose details of all transactions with the government and other government-related entities and clarifies and simplifies the definition of a related party. We will apply the amended standard from July 1, ~~2009).~~ ~~The~~2011. When the amendments are applied, we will need to disclose any transactions between our subsidiaries and associates. 0; However, we have not yet put systems into place to capture the necessary information. It is therefore not possible to disclose the financial impact, if any, of the amendment ~~requires~~on the related party disclosures.

IFRIC Interpretation 19 Extinguishing Financial Liabilities with Equity Instruments and IFRS 2009-13 Amendments to International Accounting Standards Arising from Interpretation 19 (effective from 1 July 2010). IFRIC Interpretation 19 clarifies the accounting when an entity ~~to capitalize borrowing costs directly attributable~~renegotiates the terms of its debt with the result that the liability is extinguished by the debtor issuing its own equity instruments to the ~~acquisition, construction~~creditor (debt for equity swap). It requires a gain or ~~production of a qualifying asset (one that takes a substantial period of time~~loss to ~~get ready for use~~be recognized in profit or ~~sale)~~loss which is measured as ~~part~~the difference between the carrying amount of the ~~cost~~financial liability and the fair value of ~~that asset. The option of immediately expensing those borrowing costs~~the equity instruments issued. We will ~~be removed. IAS 23 (Amendment) is not expected to have an impact on our financial statements as we have no qualifying assets.~~

~~IAS 1 (Revised), “Presentation of financial statements” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective~~apply the interpretation from July 1, ~~2009).The revised standard will prohibit the presentation of items of income and expenses (that~~2010. It is ‘non-owner changes in equity’) in the statement of changes in equity, requiring ‘non-owner changes in equity’ to be presented separately from owner changes in equity. All non-owner changes in equity will be required to be shown in a performance statement, but entities can choose whether to present one performance statement (the statement of comprehensive income) or two statements (the income statement and statement of comprehensive income). Where entities restate or reclassify comparative information, they will be required to present a restated balance sheet as at the beginning comparative period in addition to the current requirement to present balance sheets at the end of the current period and comparative period. These amendments are only expected to affect the presentation of our financial statements and will not have a direct impact on the measurement and recognition of amounts disclosed in the financial statements. We anticipate that we will present a single Statement of Comprehensive Income rather than two separate statements due to the minimum number of items expected to be classified as Other Comprehensive Income.

~~IFRS 2 (Amendment), “Share-based payment” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The amended standard deals with vesting conditions and cancellations. It clarifies that vesting conditions are service conditions and performance conditions only. Other features of a share-based payment are not vesting conditions. These features would need to be included in the grant date fair value for transactions with employees and others providing similar services; they would not impact the number of awards expected to vest or valuation there of subsequent to grant date. All cancellations, whether by us or by other parties, should receive the same accounting treatment. We have share-based payment arrangements with vesting conditions as defined under this standard; therefore these amendments are not expected to have any impact on our ~~financial statements.~~

~~IAS 32 (Amendment), “Financial instruments: Presentation,” and IAS 1 (Amendment), “Presentation of~~consolidated financial statements ~~– Puttable financial instruments and obligations arising on liquidation” (effective for annual periods~~since it is only retrospectively applied from the beginning ~~on or after January 1, 2009 and applicable to our company effective July~~of the earliest period presented (July 1, 2009) and we have not entered into any debt for equity swaps since that date.

IFRS 2009-14 Amendments to International Interpretation – Prepayments of a Minimum Funding Requirement (effective from 1 January 2011).In December 2009, the IASC made an amendment to Interpretation 14: The ~~amended standards require~~Limit on a Defined Benefit Asset, Minimum Funding Requirements and their Interaction. The amendment removes an unintended consequence of the interpretation related to voluntary prepayments when there is a minimum funding requirement in regard to an entity’s defined benefit scheme. It permits entities to ~~classify puttable financial instruments and instruments, or components~~recognize an asset for a prepayment of ~~instruments that impose on the entity an obligation~~contributions made to deliver to another party a pro rata share of the net assets of the entity only on liquidation as equity, provided the financial instruments have particular features and meet specific conditions. These amendments arecover minimum funding requirements. We do not make any such prepayments. The amendment is therefore not expected to have any impact on our consolidated financial ~~statements as we have not issued puttable financial instruments as defined by the amendments.~~

~~IAS 27 (Revised), “Consolidated and separate financial statements” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The revised standard requires the effects of all transactions with non-controlling interests to be recorded in equity if there is no change in control and these transactions will no longer result in goodwill or gains and losses. The standard also specifies the accounting when control is lost. Any remaining interest in the entity is re-measured to fair value, and a gain or loss is recognized in profit or loss.statements. We ~~began~~intend to apply ~~IAS 27 (Revised) prospectively to transactions with non-controlling interests~~the amendment from July 1, ~~2009.~~2011.

~~IFRS 3 (Revised), “Business combinations” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The revised standard continues to apply the acquisition method to business combinations, with some significant changes. For example, all payments to purchase a business are to be recorded at fair value at the acquisition date, with contingent payments classified as debt subsequently re-measured through the income statement. There is a choice on an acquisition-by-acquisition basis to measure the non-controlling interest in the acquiree either at fair vale or at the non-controlling interest’s proportionate share of the acquiree’s net assets. All acquisition-related costs should be expensed. We began to apply IFRS 3 (Revised) prospectively to all business combinations from July 1, 2009. These amendments are only expected to affect the presentation of our financial statements and will not have a direct impact on the measurement and recognition of amounts disclosed in the financial statements. These amendments are not expected to have any impact on our financial statements as we do not have any business combinations.

~~IAS 23 (Amendment), “Borrowing costs” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The amendment is part of the IASB’s annual improvements project published in May 2008. The definition of borrowing costs has been amended so that interest expense is calculated using the effective interest method defined in IAS 39 “~~Financial instruments: Recognition and~~~~measurement.” This eliminates the inconsistency of terms between IAS 39 and IAS 23.~~

IAS 28 (Amendment), “Investments in associates” (and consequential amendments to IAS 32, “Financial Instruments: Presentation,” and IFRS 7, “Financial instruments: Disclosures”) (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009). The amendment is part of the IASB’s annual improvements project published in May 2008. An investment in an associate is treated as a single asset for the purposes of impairment testing. Any impairment loss is not allocated to specific assets included within the investment, for example, goodwill. Reversals of impairment are recorded as an adjustment to the investment balance to the extent that the recoverable amount of the associate increases. We have two inactive subsidiaries and do not have any jointly controlled entities or associates and therefore our financial statements are not expected to be impacted by this standard change.

~~IAS 19 (Amendment), “Employee benefits” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The amendment is part of the IASB’s annual improvements project published in May 2008. The amendment clarifies that a plan amendment that results in a change in the extent to which benefit promises are affected by future salary increases is a curtailment, while an amendment that changes benefits attributable to past service gives rise to a negative past service cost if it results in a reduction in the present value of the defined benefit obligation. The definition of return on plan assets has been amended to state that plan administration costs are deducted in the calculation of return on plan assets only to the extent that such costs have been excluded from measurement of the defined benefit obligation. The distinction between short term and long term employee benefits will be based on whether benefits are due to be settled within or after 12 months of employee service being rendered. IAS 37, “~~Provisions, contingent liabilities and contingent assets~~~~,” requires contingent liabilities to be disclosed, not recognized. IAS 19 has been amended to be consistent.~~

~~IAS 1 (Amendment), “Presentation of financial statements” effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ The amendment is part of the IASB’s annual improvements project published in May 2008. The amendment clarifies that some rather than all financial assets and liabilities classified as held for trading in accordance with IAS 39, “~~Financial instruments: Recognition and measurement~~~~” are examples of current assets and liabilities respectively. IAS 39 (Amendment) is not expected to have an impact on our financial statements.~~

~~There are a number of minor amendments to IFRS 7, “~~~~Financial instruments: Disclosures~~~~,” IAS 8, “~~~~Accounting policies, changes in accounting estimates and errors~~~~,” IAS 10, “~~~~Events after the reporting period~~~~,” IAS 18, “Revenue” and IAS 34, “~~~~Interim financial reporting~~,” which are part of the IASB’s annual improvements project published in May 2008 (not addressed above). These amendments are unlikely to have an impact on our financial statements and have therefore have not been described in further detail.

~~IFRIC 16, “Hedges of a net investment in a foreign operation” (effective for annual periods beginning on or after January 1, 2009 and applicable to our company effective July 1, 2009).~~ IFRIC 16 clarifies the accounting treatment in respect of net investment hedging. This includes the fact that net investment hedging relates to differences in functional currency not presentation currency, and hedging instruments may be held anywhere in the group. The requirements of IAS 21, “~~The effects of changes in foreign exchange rates~~~~,” apply to the hedged item. IFRIC 16 is not expected to have a material impact on our financial statements.~~

B.	~~LIQUIDITY AND CAPITAL RESOURCES~~Liquidity and Capital Resources

We are a development stage company and have had no sales income to date, and as of June 30, ~~2009~~2010 our accumulated deficit totaled A$~~73,566,505.~~78,473,427. From inception until our initial public offering in March 2000 we financed our operations primarily through borrowings from two of our then directors, which were repaid from the proceeds of such offering. Since our initial public offering we have financed our operations primarily through sales of equity securities, proceeds from the exercise of options, government grants, licensing and research collaborations and interest earned on investments. During the period offrom 2001 to 2006, we were awarded government grants in the aggregate amount of A$3.3 ~~million;~~million, but we have not received any government grants since 2006.

In March 2003, we completed the conversion of our 7,289,310 outstanding listed options into ordinary shares. As a result of the conversion, we received approximately A$3.5 million in net proceeds, which were added to our working capital. In September 2003, we raised ~~an additional~~ approximately A$4.7 million, net of issuance costs, through a private placement of 7.1 million ordinary shares to institutional and accredited investors at a subscription price of A$0.70 per share.

In April 2004, we raised approximately US$20 million before issuance costs (A$26.4 million net of issuance costs) in a private placement in the United States (which amount was held in escrow pending receipt of the requisite approval of the transaction by our shareholders that was obtained on June 1, 2004). The private placement was for 4,000,000 ADRs to institutional and professional investors at a price of US$5.00 per ADR. The private placement also involved the acquisition by the investors of five-year warrants to purchase an additional 3,000,000 ADRs at an exercise price of US$8.00 per ADR, all of which expired without being exercised on June 4, 2009. In December 2004, we raised approximately A$4.7 million in net proceeds through the exercise of options to purchase 9,506,666 ordinary shares having an ~~exercise~~e xercise price of A$0.50 per share.

In November 2006, we raised approximately A$7.4 million net of issuance costs in a private placement of our securities to new institutional investors in Australia, institutional investors in the United States and one of our founders in Australia. The private placement was for 21.8 million ordinary shares (equivalent to 2.18 million ADRs) at a price of A$0.357 per ordinary share (approximately US$2.80 per ADR). The private placement also involved the acquisition by the investors of three-year options to purchase an additional 4.35 million ordinary shares (equivalent to 435,000 ADRs) at an exercise price of A$0.446 per ordinary share (approximately US$3.40 per ADR). To date, no options have been exercised.

In October 2007, we raised A$8.5 million (before costs) in a private placement of 29.8 million of our ordinary shares (equivalent to ~~3.0~~2.98 million ADRs) to professional and institutional investors in Australia and the United States at a price of A$0.285 per ordinary share (approximately US$2.97 per ADR) and three-year options to purchase an additional 4.94 million ordinary shares (equivalent to 494,000 ADRs) at an exercise price of A$0.37 per ordinary share (approximately US$3.85 per ADR) and an additional 4.94 million ordinary shares (equivalent to 494,000 ADRs) at an exercise price of A$0.43 per ordinary share (approximately US$4.48 per ADR). To date, no options have been exercised.

In May 2008, we raised A$7.3 million (before costs) in a private placement of 18.13 million of our ordinary shares (equivalent to 1.8 million ADRs) ~~of our ordinary shares~~ to professional investors in Australia and the United States at a price of A$0.40 per ordinary share (approximately US$4.16 per ADR).

In December 2008, we raised A$114,000 (before costs) from the exercise of options previously granted to a consultant. The options were exercised at $A0.285 per ordinary share (approximately US$4.43 per ADR).

In September 8, 2009, we ~~entered into a private placement agreement with one of our institutional shareholders in the United States, under which we will raise an aggregate~~raised A$6.0 million before costs (approximately A$5.7 million net of costs) in a private placement to one of our ~~ordinary shares to such investor. Of such amount, A$3.0 million was paid at~~institutional shareholders in the ~~closing~~United States of ~~the private placement on September 11, 2009 and an additional A$3.0 million will be paid on or before September 30, 2009. The private placement was for~~ 30 million ordinary shares (equivalent to three million ADRs) at a price of A$0.20 per share (A$2.0 per ADR). We also agreed to grant the investor, subject to shareholder approval, options to purchase 10 million ordinary shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the private placement. ~~If shareholder~~Shareholder approval ~~is not obtained for the option grant, the options will be granted at such time that shareholder approval is no longer required~~ for the issuance ~~under the rules~~ of the ~~ASX. For~~shares and option grant was obtained in November 2009. &# 160;We also agreed to issue to the investor up to an additional ~~information regarding~~3,000,000 ordinary shares, or 300,000 ADRs, if the ~~terms~~daily closing price of our ordinary shares on the ASX on any day from the date of the private placement until five days after the date on which the registration statement for the ordinary shares issued in the private placement is declared effective, declines below A$0.19, based on a formula set forth in the agreement. The foregoing condition was met and based on the agreed upon formula, we issued to the investor an additional 750,000 ordinary shares, pursuant to the approval of our shareholders obtained in November 2009. For additional information, see Item 10.C. “Additional Information –- Material Contracts.”

In July 2010, we raised A$1.15 million (US$1.0 million) (before costs) in a private placement of 7.065 million of our ordinary shares (equivalent to 0.7 million ADRs) to Quintiles, at a price of A$0.1624 per ordinary share (US$1.624 per ADR). For additional information, see Item 10.C. “Additional Information - Material Contracts.”

From inception to June 30, ~~2009,~~2010, our capital expenditures have totaled A$~~491,096~~513,761 (including A$200,000 of noncash expenditures), consisting of computer equipment, furniture and fixtures, fit-out costs and laboratory equipment that is being used in connection with our research at the University of Melbourne. Capital expenditures for equipment are depreciated on a straight-line basis over the estimated useful lives of three to 20 years, with a net balance at June 30, ~~2009~~2010 of A$~~71,150.~~58,527. We currently do not have significant capital spending requirements, but we expect to continue to engage in capital spending consistent with anticipated growth in our operations and personnel.

We had A$~~4,304,977~~5,227,298 of cash and cash equivalents at June 30, ~~2009,~~2010, compared to A$~~11,219,035~~4,304,977 at June 30, ~~2008. We~~2009.

There remains significant uncertainty as to our ability to continue as a going concern for the 12 month period ended June 30, 2011 and, therefore, whether we will realize our assets and extinguish our liabilities in the normal course of business and at the amounts stated in our consolidated financial statements for the year ended June 30, 2010. However, our directors believe ~~our existing cash and cash equivalents,~~that the ~~proceeds~~going concern basis of preparation is appropriate given the funding expected from our A$6.0 million (before costs) private placement in September 2009, as well as anticipated interest income and potential option exercises will be sufficient to support our current operating plan for at least the ~~next 12 months; however, we have based this estimate on assumptions that may prove to be incorrect. Our future funding requirements will depend on many factors, including, but not limited to:~~

following sources:

—·

~~costs~~Since inception, we have been able to raise funds to pursue our research programs, raising in excess of $85 million (before costs) through the issuance of equity and ~~timing~~warrants. In the past 12 months we have demonstrated that we can raise capital by raising A$6.0 million (before costs) through the issuance of ~~obtaining regulatory approvals;~~equity. Our directors believe that we can raise additional funding to enable us to continue to pursue our current business objectives and at our annual general meeting held on August 17, 2010, our shareholders approved the issuance of 225,000,000 ordinary shares to raise approximately A$27 million, dependant on the final issuance price.

—·

Given the ~~costs~~significant uncertainty of capital markets, other sources of funding to support the current business objectives are being pursued in parallel, including potential joint venture arrangements, merger, acquisition and ~~timing~~other means of ~~obtaining, enforcing and defending~~leveraging resources from potential partners to continue our ~~patent and intellectual property;~~business objectives over the 12 month period ended June 30, 2011. We currently have no specific plans, commitments, proposals, arrangements or agreements for any such arrangement, merger or acquisition.

—

~~the progress and success of pre-clinical and clinical trials of our product candidates; and~~

—

~~the progress and number of our research programs in development.~~

~~We anticipate~~

At this time, our directors are of the opinion that no asset is likely to be realized for an amount less than the amount at which it is recorded in the Statement of Financial Position as of June 30, 2010. Therefore, no adjustments have been made to our consolidated financial statements relating to the recoverability and classification of the asset carrying amounts or the classification of liabilities that might be necessary should we will require substantial additional funds in order to achieve our long-term goals and complete the research and development of our current principal pharmaceutical product candidate. In addition, we will require additional funds to pursue regulatory clearances, and defend our intellectual property rights, establish commercial scale manufacturing facilities, develop marketing and sales capabilities and fund operating expenses. We intend to seek such additional funding through public or private financings and/or through licensing of our assets or strategic alliances or other arrangements with corporate partners. We cannot, however, be certain that such additional financing will be available from any sources on acceptable terms, or at all, or that we will be able to license our assets or establish new strategic alliances or other arrangements with corporate partners on acceptable terms, or at all. The current global economic climate could adversely impact our ability to obtain such funding and license our assets or enter into alliances or other arrangements with corporate partners. Any shortfall in funding could result in our having to curtail or cease our operations, including our research and development activities, which would be expected to havenot continue as a ~~material adverse effect on our business, financial condition and results of operations.~~

going concern.

Cash Flows

The following table summarizes our cash flows for the periods presented:

Year ended June 30,
2009
2008
2007
(A$)

Net cash used in operating activities (6,994,174 ) (9,391,390 ) (9,199,750 )
Net cash used in investing activities (36,192 ) (81,770 ) (4,259 )
Net cash provided by financing activities 100,807 13,717,248 7,374,725
Net increase (decrease) in cash and cash equivalents (6,929,559 ) 4,244,088 (1,829,284 )
Cash and cash equivalents at beginning of period 11,219,035 7,409,256 10,013,778
Exchange rate adjustments on cash held in foreign currencies 15,501 (434,309 ) (775,238 )
Cash and cash equivalents at end of period 4,304,977 11,219,035 7,409,256

	Year ended June 30,
	2010			2009			2008
	(A$)
Net cash used in operating activities		(4,708,939	)		(6,994,174	)		(9,391,390	)
Net cash used in investing activities		(22,667	)		(36,192	)		(81,770	)
Net cash provided by financing activities		5,655,944			100,807			13,717,248
Net increase (decrease) in cash and cash equivalents		924,338			(6,929,559	)		4,244,088
Cash and cash equivalents at beginning of period		4,304,977			11,219,035			7,409,256
Exchange rate adjustments on cash held in foreign currencies		(2,017	)		15,501			(434,309	)
Cash and cash equivalents at end of period		5,227,298			4,304,977			11,219,035

Net cash used in operating activities was A$4,708,939, A$6,994,174 ~~A$9,391,390~~ and A$~~9,199,750~~9,391,390 during the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, respectively. Our payments to suppliers and employees during the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007~~2008 were A$4,923,648, A$7,511,372 and A$9,766,851, respectively. The decrease from the year ended June 30, 2009 to the year ended June 30, 2010 was primarily due to a decrease in research and development expenditure. During the year ended June 30, 2010, our research and development expenditure was offset by a A$~~9,726,197, respectively.~~2,252,385 one-time reimbursement under a research and development contract. The decrease from the year ended June 30, 2008 to the year ended June 30, 2009 was primarily due to decrease in research and development expenditure. ~~The increase in payments from the year ended June 30, 2007 to the year ended June 30, 2008 was primarily due to an increase in research and development expenditure.~~ During the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, our payments to suppliers and employees was offset by interest income of A$214,709, A$517,198 and A$375,461, ~~and A$526,447,~~ respectively.

Net cash used in investing activities was A$22,667, A$36,192 ~~A$81,770~~ and A$~~4,259~~81,770 during the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, respectively. Cash flows used for investing activities was primarily attributable to payments for the purchase of property and equipment for the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007.~~

2008. Net cash provided by financing activities was A$5,655,944, A$100,807 ~~A$13,717,248~~ and A$~~7,374,725~~13,717,248 for the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007.~~2008. Cash flows provided by financing activities during the year ended June 30, 2010 are attributable to a private placement of our ordinary shares to an institutional investor in the United States in September 2009. Cash flows provided by financing activities during the year ended June 30, 2009 ~~are~~ar e attributable to a consultant exercising options to purchase 400,000 ordinary shares at an exercise price of A$0.285 per share (after costs). Cash flows provided by financing activities during the year ended June 30, 2008 are attributable to private placements of our ordinary shares in Australia and the United States in October 2007 and May 2008. ~~Cash flows provided by financing activities during~~

We realized a foreign exchange loss of $A2,017 for the year ended June 30, ~~2007 are attributable~~2010 compared to a private placement in November 2006 of 21.8 million ordinary shares (equivalent to 2.18 million ADRs) at a price of A$0.357 per ordinary share (approximately US$2.80 per ADR). The private placement also involved the acquisition by the investors of three-year options to purchase an additional 4.35 million ordinary shares (equivalent to 435,000 ADRs) at an exercise price of A$0.446 per ordinary share (approximately US$3.40 per ADR).

~~We realized~~ a foreign exchange gain of A$15,501 for the year ended June 30, ~~2009. We realized~~2009 and a foreign exchange ~~losses~~loss of A$434,309 ~~and A$775,238~~ for the ~~years~~year ended June 30, ~~2008 and 2007, respectively.~~2008. In 2008 and ~~2007,~~2010, the Australian dollar appreciated against the U.S. dollar by 11% and 5%, respectively, while in 2009, the Australian dollar depreciated against the U.S. dollar by ~~11% and 12%, respectively, while the Australian dollar appreciated against the U.S. dollar by~~ 16% ~~in 2009.~~

C.	~~RESEARCH AND DEVELOPMENT, PATENTS AND LICENSES~~Research and Development, Patents and Licenses

Early in our company’s history, our activities were primarily focused on the acquisition and development of patents to enable the research and development of our core technology. In January 2001, we entered into an exclusive license agreement with the General Hospital Corporation to access patented technologies that could be of assistance in the discovery and characterization of lead compounds (see Item 4.B. “Information on the Company –- Business Overview –- Patents and License Agreements”). This license also provided us access to PBT1 (clioquinol) for drug development in Alzheimer’s disease. To build a cost effective research and development company, in December 2000 we entered into an agreement with the University of Melbourne to conduct on our behalf certain research programs in Alzheimer’s disease and other neurological disorders, to undertake basic mechanistic research on our compounds and conduct screens to assess therapeutic utility of our compounds (see Item 10 “Additional Information –- Material Contracts”). In recent years, we increased our practice of building valuable research collaborations with institutes based in Australia, the United States, the United Kingdom and other countries to enable us to investigate a variety of therapeutic indications including Huntington’s disease, cancers, Parkinson’s disease and age-related macular degeneration. These collaborative arrangements ensure that we work with well-respected laboratories with specific expertise in screening and animal modeling of relevance to the particular indication, without incurring ongoing administrative and personnel costs. We maintain in-house patent counsel and research and development project expertise to coordinate these research collaborations.

When a lead compound is identified as suitable for clinical development, we establish a project team to coordinate all pre-clinical and clinical development and manufacturing activities. Typically, we engage a clinical research organization to manage patient recruitment, data management and trial conduct and reporting, as was the case with the development of our lead compound PBT2 through Phase I and Phase II development. All clinical, pre-clinical, clinical development and manufacturing of our compounds is performed in compliance with the appropriate governing authorities and standards (for example, the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use).

Research and development expenses,net amounted to A$87,992, A$2,215,358 ~~A$5,757,168~~ and A$~~4,492,193~~5,757,168 during the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, respectively. Costs associated with patent applications and defense of patent applications are classified as intellectual property expenses and amounted to A$431,082, A$1,107,534 ~~A$469,428~~ and A$~~600,232~~469,428 during the years ended June 30, 2010, 2009 and 2008, ~~and 2007,~~ respectively.

Our research and development expenses consist primarily of ~~compensation and related costs~~expenses for contracted research and development activities conducted by third parties on our behalf, including personnel, ~~expenses for~~ testing facilities and other payments ~~under~~in accordance with our research ~~and/or~~and clinical agreements. Research and development expenses also include costs associated with the acquisition and development of ~~patents subsequent to December 1999.~~patents. We do not maintain accounting systems to accurately track research and development costs on an individual project basis because a significant portion of our historic research and development expenses benefited our two major research and development projects, and therefore were not tracked individually by project; rather, we tracked these costs by the type of costs incurred. Such costs are charged to operations as incurred. See Note 34 to the consolidated financial statements. Due to the numerous variables and the uncertain nature of the development of a clinical compound, we are not able to reasonably estimate the nature, timing and costs of the future expenditures necessary to complete our research and development projects, the anticipated completion dates of each project and when material net cash flows from our research and development programs will commence.

D.	~~TREND INFORMATION~~Trend Information

We are a development stage company and it is not possible for us to predict with any degree of accuracy the outcome of our research or commercialization efforts.

E.	~~OFF-BALANCE SHEET ARRANGEMENTS~~Off-Balance Sheet Arrangements

We are not a party to any material off-balance sheet arrangements. In addition, we have no unconsolidated special purpose financing or partnership entities that are likely to create material contingent obligations.

F.	~~TABULAR DISCLOSURE OF CONTRACTUAL OBLIGATIONS~~Tabular Disclosure of Contractual Obligations

The following table summarizes our minimum contractual obligations as of June 30, ~~2009.~~

Contractual Obligations
Payments due by period
Total
less than
1 year
1-3 years
3-5
Years
more than
5 years

Operating lease obligations $ 150,932 $ 110,411 $ 40,521 - -
Purchase obligations* $ 528,889 $ 485,861 $ 43,028 - -
Total $ 679,821 $ 596,272 $ 83,549 - -

2010.

Contractual Obligations	Payments due by period
	Total		less than 1 year		1-3 years		3-5 Years		more than 5 years
Operating lease obligations		152,672		114,152		38,520		-		-
Purchase obligations*		2,238,230		2,151,895		86,335		-		-
Total		2,390,902		2,266,047		124,855		-		-

_____________________

* Purchase obligations relate solely to our patents and license agreements described under Item 4.B. “Information on the Company - Business Overview - Patents and License Agreements.” and our research and development agreement described under Item 10 “Additional Information - Material Contracts.” Purchase obligations exclude obligations under our employment agreements with Mr. Geoffrey Kempler, our Chief Executive Officer, and Ms. Dianne Angus, our Chief Operating Officer (see Item 6.C. “Operating and Financial Review and Prospects - Compensation”) and our consulting agreement with Professor Ashley Bush (see Item 10. “Additional Information - Material Contracts”). See Note 20 to our consolidated financial statements.

* Purchase obligations relate solely to our patents and license agreements described under Item 4.B. “Information on the Company – Business Overview – Patents and License Agreements.” and our research and development agreement described under Item 10 “Additional Information – Material Contracts.” Purchase obligations exclude obligations under our employment agreements with Mr. Geoffrey Kempler, our Chief Executive Officer, and Ms. Dianne Angus, our Chief Operating Officer (see Item 6.C. “Operating and Financial Review and Prospects – Compensation”) and our consulting agreement with Professor Ashley Bush (see Item 10. “Additional Information – Material Contracts”). See Note 20 to our consolidated financial statements.

ITEM 66.

DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES

A.	~~DIRECTORS AND SENIOR MANAGEMENT~~Directors and Senior Management

Our directors and executive officers are as follows:


	Name		Age		Position



Geoffrey P. Kempler	54	55		Chairman of the Board of Directors and Chief Executive Officer

Richard Revelins	47	48		Chief Financial Officer and Secretary

Dianne Angus	49	50		Chief Operating Officer
Paul Marks		60		Director
Peter Marks(1)	53	54		Director

Brian D. Meltzer(1)(2)	55	56		Director

George W. Mihaly(1)(2)	56	57		Director

~~(1)~~

~~Member of the Audit Committee~~

~~(2)~~

~~Member of the Remuneration Committee, Share Plan Committee and Nominations Committee~~

_________________________

(1) Member of the Audit Committee

(2) Member of the Remuneration Committee, Share Plan Committee and Nominations Committee

Geoffrey Paul Kempler has served as the Chairman of our Board of Directors since November 1997, between November 1997 and August 2004 he served as our Chief Executive Officer, and in June 2005 he again assumed the position of Chief Executive Officer. Mr. Kempler is one of the founders of our company. Mr. Kempler is a qualified psychologist. Mr. Kempler, who has extensive experience in investment and business development, has been responsible for the implementation of our strategic plan and the commercialization of our technology. Mr. Kempler holds a B.Sc degree in science from Monash University and a Grad. Dip. App. Soc. Psych. degree from Swinburne University.

Richard Revelins has served as our Company Secretary since February 2000 and was appointed Chief Financial Officer of our company in June 2004. Mr. Revelins is an executive director and principal of Peregrine Corporate Limited, an Australian-based investment bank. Mr. Revelins has held senior positions in international merchant ~~banks~~banks. Mr. Revelins is currently the chairman of the board of directors of Entermo Ltd. and is ~~currently~~ a director of Mining Project Group Limited, which is listed on the ASX as well as of a number of private companies. Mr. Revelins holds a Bachelor of Economics degree from Monash University, Melbourne. Mr. Revelins serves as our Chief Financial Officer on a part-time basis and devotes approximately one to two work days a ~~week~~we ek to such position.

Dianne Angus has served as our Chief Operating Office since May 2007. Ms. Angus joined our company in August 2002, initially serving as our Vice President of Intellectual Property and Licensing, she was promoted to Senior Vice President of Business Development, Intellectual Property and Research in July 2004 and served in that position until being promoted to her current position in May 2007. From 1992 to 2000, Ms Angus managed the intellectual property, licensing and biotechnology product development assets of two Australian companies, AMRAD Corporation Limited and Florigene Limited. At Florigene, Ms. Angus was the joint venture alliance ~~manger~~manager with Suntory for 3three years. From June 2000 to August 2002, Ms Angus was Director of Dianne ~~Angus~~A ngus and Associates Pty. Ltd. providing strategic business development, technology evaluation and intellectual property consulting services to biotechnology companies. Ms. Angus has worked in the commercial biotechnology sector for over 1718 years directing product valuation, acquisition and product licensing. During her career, Ms. Angus has managed large and diverse intellectual property portfolios, contract rights and enforcement. Ms Angus has negotiated and executed many commercial licenses and research and product development agreements with entities ranging from ~~Novartis, Monsanto, Suntory and Du Pont~~large pharmaceutical companies to numerous global research institutes. Ms. Angus has also undertaken due diligence assessments on several Australian biotechnology companies for investment brokers. Ms. Angus holds a Bachelor of Science (Education) and Bachelor of Science (Honours) degree from the University of Melbourne, a Masters degree in Biotechnology from Monash University, a Graduate Diploma in ~~Intellectual~~Inte llectual Property Law from Monash University, a Diploma in Intellectual Property Practice from the Institute of Patent and Trademark Attorneys of Australia and is a registered Australian Patent and Trade Mark Attorney.

Paul Marks was appointed by our Board of Directors to serve as a director of our company in January 2010. Mr. Marks has extensive experience in healthcare and mining investment, foreign exchange and commodities trading. Mr. Marks was Vice-President of Foreign Exchange with Prudential-Bache Securities and Senior FX Strategist with National Australia Bank. Since the mid-1990’s, Mr. Marks has specialized in private investments in listed and unlisted companies. Mr. Marks is also a director of Conquest Mining Limited (ASX: CQT) and is on the board of directors of several private companies. Mr. Marks holds a Bachelor of Chemical Engineering degree and a Masters degree in Applied Finance

Peter Marks has served as a director of our company since July 2005. Since November 21, 2006, Mr. Marks has also served as Executive Chairman of KarmelSonix Ltd, a medical devices company listed on the ASX that is focused on developing and commercializing a range of devices in the respiratory and medicine space. Mr. Marks is currently also a director of Peregrine Corporate Limited, an Australian-based investment bank, and Watermark Global Plc, an AIM listed company, which commercializes the treatment and recycling of acid mine drainage water from South African mines. From September 1998 until March 2001, Mr. Marks was employed by KPMG Corporate Finance Ltd (Australia), where he rose to Director and was responsible for heading up the equity capital ~~markets~~ma rkets group in Melbourne. From January 1992 until July 1994, Mr. Marks served as Head of the Melbourne Companies Department at the ASX and was founding Director of Momentum Funds Management Pty Ltd, an Australian venture capital firm. From December 1990 until December 1991, Mr. Marks served as Director of Corporate Finance at Burdett Buckeridge & Young Ltd in their Melbourne offices, from August 1988 until November 1990, he held senior corporate finance positions at Barings Securities Ltd, and from July 1985 until July 1988, he served as an Associate Director of McIntosh Securities, now Merrill Lynch Australia. In his roles with these various financial institutions, Mr. Marks was responsible for advising a substantial number of listed and unlisted companies on issues ranging from corporate and company structure, to valuations, business strategies, acquisitions and international opportunities. Mr. Marks holds a Bachelor of Economics degree, a Bachelor of Law degree and Graduate ~~Diploma~~Diplo ma in Commercial Law from Monash University in Melbourne, Australia, and an MBA degree from the Scottish School of Business at the University of Edinburgh.

Brian Derek Meltzerhas served as a director of our company since December 1999. Mr. Meltzer has over 30 years experience in economics, finance and investment banking. Mr. Meltzer is a ~~Director~~director of Momentum Ventures Limited, licensed by the government as an Innovation Investment Fund with venture capital investments including biotechnology. Mr. Meltzer is a non-executive director on the board of directors of a number of private companies. Mr. Meltzer is also a director on the board of directors of the Australian-Israel Chamber of Commerce and ~~the Paraplegic and Quadriplegic Association~~is Deputy Chairman of ~~Victoria (Paraquad)~~Independence Australia (previously Paraquad). Mr. Meltzer is Chairman of our Audit Committee, Remuneration Committee and Nomination Committee. Mr. Meltzer ~~holds~~ho lds a Bachelor of Commerce degree from the University of Auckland and a Master of Economics degree from Monash University.

Dr. George William Mihaly has served as director of our company since December 1999. Dr. Mihaly also serves as a director of Waide Pty Ltd., a private company. DrDr. Mihaly has had an extensive and successful career spanning the research and commercial facets of the pharmaceutical industry. During the period from mid-1994 to early 2000, DrDr. Mihaly was the founding executive Chairman and Managing Director of Synermedica Pty Ltd, or Synermedica, , one of Australia’s leading independent consultant research organizations to the pharmaceutical industry. Synermedica merged with the global consultant research organization Kendle International Inc. in April 2000 and DrDr. Mihaly continued as Managing Director of the merged entity in Australia (now called ~~Kendle~~Ken dle Pty Ltd) until December 2004. Over the course of the last 2435 years in academia and industry, DrDr. Mihaly has amassed extensive experience in both the science and logistics of setting up, monitoring, managing and evaluating results from Phase I, II, III and IV clinical trials. Dr. Mihaly holds a B.Pharm. from Monash University, an M.Sc. degree from Sydney University and a Ph.D. degree from Melbourne University, and he is a fellow of the Australian Institute of Company Directors.

There are no family relationships among our directors and senior executives.

B.	~~COMPENSATION~~Compensation

The following table sets forth all compensation we paid for the year ended June 30, ~~2009~~2010 with respect to each of our executive officers and directors during the ~~2009~~2010 fiscal year.


					Salaries, fees, commissions and bonuses (1)			Pension, retirement and other similar benefits



	Geoffrey P. Kempler (2)	~~A $~~	~~329,896~~ A$	-403,402			--
	Richard Revelins	~~A $~~	~~66,667~~ A$	-80,000			--
	Dianne Angus (3)	~~A $~~	~~318,559~~ A$	-377,307			--
Paul Marks	~~Peter Marks~~	~~A $~~A$	~~45,833~~ 18,334	-		--
Peter Marks		A$	55,000			--
Brian D. Meltzer	~~A $~~	~~75,000~~ A$	-90,000			--
	George W. Mihaly	~~A $~~	~~62,500~~	-

75,000

______________

(1)

Does not include A$~~497,321~~213,348 of expenses attributable to equity-based compensation recorded in fiscal year ~~2009.~~2010.

(2)

Mr. Kempler has elected not to ~~reduce his compensation from the beginning of May 2009, and has also elected to not~~ accept aan A$100,000 incentive bonus to which he is entitled until further notice.

(3)

Includes a A$50,000 bonus awarded to Ms. Angus in recognition of her performance in 2009 and continued commitment to our company.

In accordance with the approval of our shareholders at our 2004 annual general meeting of shareholders, the aggregate amount available per annum for the remuneration of our non-executive directors for their services (payable in cash, ordinary shares or options) is A$1,250,000.

During the year ended June 30, 2010, we granted to Ms. Diane Angus options to purchase 292,256 ordinary shares. We did not grant options to any other executive officer or our directors during the year ended June 30, 2010. As of June 30, ~~2009,~~2010, our directors and executive officers as a group, then consisting of ~~six~~seven persons, held options to purchase an aggregate ~~8,194,837~~6,988,847 of our ordinary shares. Of such options, (i) options to purchase 1,900,000 ordinary shares are currently exercisable for nil consideration on or before June 30, 2010. Such options may not be exercised until and unless the price of our ordinary shares has achieved and maintained a minimum value of A$1.00 for five consecutive trading days. The ordinary shares issued upon exercise of these options may not be disposed of without the prior consent of our Board of Directors; (ii) options to purchase 2,200,000 ordinary shares are exercisable for nil consideration on or before July 31, 2009. Such options may not be exercised until and unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.80 for five consecutive trading days. The ordinary shares issued upon exercise of these options may not be disposed of without the prior consent of our Board of Directors; (iii) options to purchase 1,444,837 ordinary shares are exercisable for nil consideration on or before August 7, 2014. Such options may not be exercised until and unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.40 for five consecutive trading days; ~~(iv)~~(ii) options to purchase 2,400,000 ordinary shares are exercisable for ~~$0.30~~A$0.30 consideration on or before October 31, ~~2010. Such options were held in escrow until December 20, 2008; and (v)~~2010; (iii) options to purchase 250,000 ordinary shares are exercisable for nil consideration on or before October 31, ~~2010.All~~2010; (iv) options to purchase 350,877 ordinary shares are exercisable for A$0.37 consideration on or before October 31, 2010; (v) options to purchase 350,877 ordinary shares are exercisable for A$0.43 consideration on or before November 30, 2010; (vi) options to purchase 292,256 ordinary shares are exercisable for A$0.15 consideration on or before March 31, 2014; and (vii) options to purchase 1,900,000 ordinary shares are exercisable for nil consideration on or before June 30, 2010. All such options were granted under our 2004 Employees’, Directors’ & Consultants’ Share and Option Plan. See Item 6.E. “Directors, Senior Management and Employees –- Share Ownership – Stock Option Plans.”

Agreement with Chief Executive Officer. On September 21, 2007, we entered into an agreement with Mr. Geoffrey Kempler, a director, in connection with his employment as our Chief Executive Officer. Under the agreement, we agreed to pay Mr. Kempler a base salary of A$386,400 per annum (which may be increased at the discretion of our Board of Directors). On June 5, 2008 at the discretion of our Board of Directors, Mr. Kempler received a salary adjustment for CPI of 4.4% effective July 1, 2008, increasing his base salary to A$403,402. ~~Under the agreement we~~We also agreed to pay Mr. Kempler a bonus of $50,000 upon a capital raising of at least A$7.0 million (before costs) prior to September 30, 2007, which milestone was timely met and therefore we paid such bonus tot o Mr. Kempler in the 2008 fiscal year. In addition, Mr. Kempler is entitled to a bonus of ~~$6,000~~A$6,000 for holding regular meetings (minimum twice a year) of the full Research and Development Advisory Board. We also agreed to pay Mr. Kempler additional bonuses subject to certain milestones that were not timely met and therefore he is no longer entitled to such bonuses. Mr. Kempler is entitled to (i) up to 20 days vacation a year. Vacation days that are not used in any calendar year will be carried over for use in the following year to a maximum carry-over of two years; and (ii) reimbursement of reasonable business expenses incurred in the performance of his duties. Mr. Kempler is also entitled to participate in the employee benefits established by our company, as applicable to executives, including, without limitation, a Section 401(k) retirement plan, health, dental, life insurance and short and long term disability plans.

In the event of termination of Mr. Kempler’s employment:

—·

By our company without cause (as defined in the agreement) or by Mr. Kempler with good reason (as defined in the agreement), he will be entitled to: (i) the sum of A$1 million provided we have sufficient capital requirements to fulfill this obligation within 90 days of termination date; (ii) business expenses that have not been reimbursed and accrued and unused vacation days; and (iii) the acceleration of the vesting of any unvested options to purchase ordinary shares which may be purchased during the remainder of the exercise period of such options.

—·

By our company with cause (as defined in the agreement) or by Mr. Kempler without good reason (as defined in the agreement), he will be entitled to business expenses that have not been reimbursed and accrued and unused vacation days. Mr. Kempler will only be permitted to exercise unvested options to purchase shares that had been granted to him prior to the employment agreement.

—·

Due to death or disability (as defined in the agreement), we shall pay Mr. Kempler or his estate, as applicable, all accrued base salary, pro-rata bonus, business expenses that have not been reimbursed and accrued, unused vacation days (and in the case of disability, less such amounts under any disability policy maintained by our company). Mr. Kempler or his estate, as applicable, will be entitled to exercise vested options for ordinary shares.

The agreement contains customary confidentiality provisions.

Agreement with Chief Operating Officer. Effective as of October 2, 2006, we entered into an employment agreement with Ms. Dianne Angus, in connection with her appointment as our Senior Vice President, Business Development, Intellectual Property and Research. Under the agreement we agreed to pay Ms. Angus a base salary of A$268,125 per year, plus superannuation equivalent to 9% of the base salary (or the percentage stipulated by applicable Australian law). In addition, we agreed that we would grant to Ms. Angus options to purchase 1,000,000 ordinary shares, which were granted in the 2007 fiscal year. Such options are exercisable for nil consideration on or before August 7, 2014 and will not be exercisable unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.40 for five consecutive trading days. The options were granted under the 2004 ASX Plan. On June 12, 2007, we entered into an amendment to ~~the~~an employment agreement with Ms. Angus in connection with her appointment as our Chief Operating Officer, effective as of May 31, ~~2007.All entitlements~~2007. Under the amended agreement we agreed to pay Ms. Angus a base salary of A$268,125 per year, plus superannuation equivalent to 9.0% of the base salary (or the percentage stipulated by applicable Australian law). Effective May 1, 2010, Ms. Angus received a salary increase of 8% bringing her annual base salary to A$315,637. In addition, under the ~~October 2, 2006 agreement remain in full force and effect. Under the June 12, 2007~~amended agreement, we granted to Ms. Angus options to purchase an additional 250,000 ordinary ~~sharesin~~shares in recognition of our company’s achievements and performance. Such options are exercisable for nil consideration on or before August 7, 2014 and will not be exercisable unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.40 for five consecutive trading days. The options were granted under the 2004 ASX ~~Plan.~~Plan (as defined below). If we terminate the employment agreement without cause or if Ms. Angus terminates the employment agreement with good reason (as such terms are defined in the agreement) (i) we will pay to Ms. Angus, within 90 days of such termination, the sums she would have been entitled to receive had she continued to provide services for one year following the termination date; and (ii) any unvested options shall be accelerated and will become fully vested and she will be entitled to exercise her options during the remainder of their ~~term~~. Effective January 1, 2008, Ms. Angus received a salary increase of 9% bringing her annual base salary to A$292,256. In May 2009, in recognition of her performance in 2008 and continued commitment to our company, we awarded Ms. Angus with a grant of options to purchase 194,837 ordinary shares. Such options are exercisable for nil consideration on or before 2014.term.

C.	~~BOARD PRACTICES~~Board Practices

Introduction

Our Board of Directors is elected by and accountable to our shareholders. Our Board of Directors’ responsibilities are divided into operating activities, financial and capital markets activities and scientific activities. The Chairman of our Board of Directors, currently Mr. Geoffrey Kempler, is responsible for the management of the Board of Directors and its functions.

Election of Directors

Directors are elected at our annual general meeting of shareholders. Under our Constitution, the term of office of our directors are staggered, such that at every annual general meeting of shareholders one-third, rounded down to the nearest whole number, of the directors, except a Managing Director, must retire from office and may offer himself/herself for re-election. No director, except a Managing Director, shall retain office for a period in excess of three years without submitting for re-election. Under Australian law, directors who have reached the age of 72 must stand for re-election annually. Our Board of Directors has the power to appoint any person to be a director, either to fill a vacancy or as an additional director (provided that the total number of directors does not exceed the ~~maximum~~ma ximum allowed by law), and any director so appointed may hold office only until the next annual general meeting when he or she shall be eligible for election. Mr. Kempler is our Managing Director. Dr. Mihaly must retire and may stand for re-election at our ~~2009~~2012 annual general meeting of shareholders. Messrs. Paul Marks and Brian Meltzer must retire and may stand for re-election at either our 2010 or 2011 annual general meeting of shareholders.

Mr. Paul Marks was appointed by our board of directors as a director in January 2010 and will stand for election at our 2010 annual general meeting of shareholders.

Non-Executive and Independent Directors

Australian law does not require a company to appoint a certain number of independent directors to its board of directors or audit committee. However, under the ASX Best Practice Guide, the ASX recommends, but does not require, that aan ASX-listed company have a majority of independent directors on its board of directors and that the audit committee be comprised of independent directors, within the meaning of the rules of the ASX. Our Board of Directors currently has four directors, of which three are non-executive directors within the meaning of the ASX Best Practice Guide, and our audit committee consists of such three non-executive directors. Accordingly, we currently comply with the foregoing recommendations of the ASX Best Practice Guidance.

Under NASDAQ ~~Marketplace~~Listing Rules, in general a majority of our Board of Directors must qualify as independent directors within the meaning of the NASDAQ ~~Marketplace~~Listing Rules and our audit committee must have at least three members and be comprised only of independent directors, each of whom satisfies the respective “independence” requirements of NASDAQ and the Securities and Exchange Commission.

Our Board of Directors has determined that each of Messrs. Peter Marks and Brian Meltzer and Dr. George Mihaly qualifies as an independent director under the requirements of the ASX, NASDAQ ~~Marketplace~~Listing Rules and Securities and Exchange Commission.

Committees of the Board of Directors

Our Board of Directors has established the following committees:

Audit Committee. NASDAQ ~~Marketplace~~Listing Rules require us to establish an audit committee comprised of at least three members, each of whom is financially literate and satisfies the respective “independence” requirements of the Securities and Exchange Commission and NASDAQ and one of whom has accounting or related financial management expertise at senior levels within a company.

Our Audit Committee assists our Board of Directors in overseeing the accounting and financial reporting processes of our company and audits of our financial statements, including the integrity of our financial statements, compliance with legal and regulatory requirements, our independent public accountants’ qualifications and independence, the performance of our internal audit function and independent public accountants, and such other duties as may be directed by our Board of Directors. The Audit Committee is also required to assess risk management.

Our Audit Committee currently consists of three board members, each of whom satisfies the “independence” requirements of the Securities and Exchange Commission, NASDAQ ~~Marketplace~~Listing Rules and ASX Rules. Our Audit Committee is currently composed of Messrs. Peter Marks and Brian Meltzer and Dr. George Mihaly. The audit committee meets at least four times per year.

Remuneration Committee.Our Board of Directors has established a Remuneration Committee, which is comprised solely of independent directors, within the meaning of NASDAQ ~~Marketplace~~Listing Rules. The Remuneration Committee is responsible for reviewing the salary, incentives and other benefits of our executive officers and to make recommendations on such matters for approval by our Board of Directors. The Remuneration Committee is also responsible for overseeing and advising our Board of Directors with regard to the adoption of policies that govern our compensation programs, including share and ADR option and employee benefit plans. Additionally, the Remuneration Committee administers ~~our~~o ur share and ADR option plans and any other employee benefit plans through a sub-committee that it established for this purpose (see Share Plan Committee below). ~~Messrs.~~Dr. Mihaly and Mr. Meltzer are the current members of the Remuneration Committee, each of whom qualifies as an “independent director” within the meaning of NASDAQ ~~Marketplace~~Listing Rules.

Share Plan Committee. Our Remuneration Committee has established a sub-committee, the Share Plan Committee, which administers our share and ADR option plans. ~~Messrs.~~Dr. Mihaly and Mr. Meltzer are the current members of the Share Plan Committee, each of whom qualifies as an “independent director” within the meaning of NASDAQ ~~Marketplace~~Listing Rules.

Nominations Committee. Our Board of Directors has established a Nominations Committee, which is comprised solely of independent directors, within the meaning of NASDAQ ~~Marketplace~~Listing Rules. The Nominations Committee is responsible for identifying and recommending to the Board of Directors director nominees for election at the annual meetings of shareholders, as well as candidates to fill any vacancies on the Board of Directors or as an addition to existing directors. ~~Messrs.~~Dr. Mihaly and Mr. Meltzer are the current members of the Nominations Committee, each of whom qualifies as an “independent director” within the meaning of NASDAQ ~~Marketplace~~Listing Rules.

Research and Development Advisory Board. Our Research and Development Advisory Board oversees and administers our research activities. Our Research and Development Advisory Board is comprised of a number of the leading scientists in the field of age-related degenerative disorders. The members of our Scientific Advisory Board are as follows:

Dr. Jeffrey Cummingsis the Chairman of our Research and ~~DevelopmentAdvisory~~Development Advisory Board. Dr. Cummings is the Director of the Cleveland Clinic Lou Ruvo Center for Brain Health and ~~founder~~the Andrea and Joseph Hahn Professor of Neurotherapeutics. The Lou Ruvo Center for Brain Health provides clinical care to patients, promotes innovative programs for caregivers, and advances translational research and clinical trials for Alzheimer’s disease and related disorders. Dr. Cummings was formerly the director of the UCLA Alzheimer’s Disease Center; the Augustus S. Rose Professor of Neurology at UCLA and the Director of the ~~UCLA Behavioral Neuroscience and Dementia Research Fellowship.~~Deane F. Johnson Center for Neurotherapeutics. Dr. Cummings’ interests embrace clinical trials and the development of new treatments for neurodegenerative disorders and other neurological diseases. ~~He has authored or edited 20 books and over 450 peer reviewed papers.~~ Dr. Cummings has broad interests in dementing disorders, neuropsychiatry, neurotherapeutics and the interface of neuroscience and society. ~~The UCLA Alzheimer’s Disease Center has an active clinical trials program~~

Dr. Ashley Bush (MB BS, DPM, FRANZCP, PhD, FTSE) is a psychiatrist and ~~fosters imaging, genetics, clinical and neuroscience research.~~~~Professor Ashley Ian Bush~~ istranslational neuroscientist, who heads the ~~Director of the Laboratory for~~ Oxidation Biology ~~within~~Laboratory at the ~~Genetics~~Mental Health Research Institute, University of Melbourne, Australia, and ~~Aging Unit~~also has academic appointments in psychiatry at ~~the~~ Massachusetts General Hospital, or MGH, and ~~Associate Professor in the Department of Psychiatry of Harvard Medical School. Professor~~neuroscience at Cornell University. Dr. Bush is ~~also Principal Fellow/Associate Professor, Departments~~the recipient of ~~Pathology and Psychiatry, University of Melbourne. Professor~~numerous awards including the Potamkin Prize for Alzheimer’s disease research. Dr. Bush ~~born and educated~~received his PhD in ~~Melbourne, established his~~Colin Masters’ laboratory at the ~~Massachusetts General Hospital after receiving~~University of Melbourne, performed post-doctoral studies with Rudy Tanzi at MGH, directed a laboratory at MGH from 1995-2005, whereupon he took up a professorship as Australian Research Council Federation Fellow at his current location . Dr. Bush discovered the ~~distinguished Harness Fellowship~~interaction of beta-amyloid with zinc as a major factor in ~~1992. His discovery~~Alzheimer’s disease pathogenesis, and focuses on the neurobiology of ~~the role of metals and oxidative stress~~metal ions in ~~Neurological disorders has formed the basis of our platform technology.~~neurodegenerative disorders.

Professor Jean-Marc Orgogozo, MD, is the Chair of the Department of ~~Neurology~~Clinical Neurosciences and Professor of Neurology at the University of Bordeaux, France. Professor Orgogozo has extensive experience in neuroepidemiology and clinical ~~trials.~~trials, particularly in stroke and dementia. Professor Orgogozo’s early publications on the amyloid vaccines have helped to shape the field of anti-amyloid therapeutics. Professor Orgogozo’s main therapeutic research now is on the prodromal phase of Alzheimer’s disease.

Dr. Craig Ritchie is the Clinical Research Fellow (Senior), Old Age Psychiatry at Imperial College, London. Dr. Ritchie is heavily involved, both clinically and academically, in psychiatric disorders of late life, in particular ~~Alzheimer’s~~Alzheimer‘s disease, ~~Delirium~~delirium and ~~Schizophrenia.~~schizophrenia. Dr. Ritchie’s interest in conducting and assimilating evidence from clinical trials is based on his clinical background, having worked with elderly patients with dementia for most of his career.

Professor Colin Masters is the Executive Director of the Mental Health Research Institute ~~of Victoria~~ (Australia) and an ex-founding director of our company. For more than 30 years, Professor Masters has dedicated his research to the study of the nature of Alzheimer’s disease and other neurodegenerative disorders. Professor Masters and his team are internationally renowned for their work on the disease and he is considered the most eminent neuroscientist in Australia. In addition, Professor Masters is regarded as one of the leading worldwide researchers in the study of Alzheimer’s disease. In ~~the last year,~~2006, Professor Masters was awarded the Lifetime Achievement Award in ~~Alzheimer’s~~Alzheimer‘s Disease Research at the 10th International Conference on ~~Alzheimer’s~~Alzheimer̵ 6;s Disease (ICAD), the Lennox K. Black International Prize for Excellence in Biomedical Research and the Grand Hamdan International Award for a research breakthrough in the subject of Molecular and Cellular Pathology of Neurological Disorders.

Professor Rudolph Emile Tanziis athe Joseph P. and Rose F. Kennedy Professor of Neurology at the Harvard Medical School and ~~Associate Geneticist, Neurology Services, the~~ Director of Genetics and the Aging Research Unit at ~~the Massachusetts General Hospital.~~MGH. Professor Tanzi ~~played a lead role in~~co-discovered three of the ~~discovery of~~four known Alzheimer’s disease genes and contributed greatly to elucidating the molecular mechanisms ~~that underlie the~~by which they cause of Alzheimer’s ~~disease, particularly as they relate to the molecular genetics of this disorder.~~disease. Professor Tanzi’s laboratory at ~~the Massachusetts General Hospital~~MGH is one of the leaders in the field. ~~Over~~Professor Tanzi conceived the ~~last ten~~“Metal Hypothesis of Alzheimer's Disease” with Dr. Ashley Bush, and over the past 15 years ~~Professor Tanzi~~ has helped guide the design and development of our platform technology.

Dr. Steven D. Targum is our Chief Medical Advisor. ~~Dr. Targum is an Executive-in-Residence at Oxford Bioscience Partners, where he advises portfolio companies in central nervous system, or CNS, drug development. In addition,~~ Dr. Targum consults widely to the pharmaceutical industry regarding the design and implementation of clinical trials for new psychotropic drugs and the progression of drug development from concept to approval to launch. Dr. Targum is well known for his expertise in clinical trials methodologies. In this capacity, Dr. Targum founded both PharmaStar aand Clintara LLC, global rater training and medical education ~~company~~companies focused on ~~CNS~~central nervous system drug development and international clinical trials. ~~Previously, Dr. Targum was~~Dr.Targum has been Professor of Psychiatry and Vice-Chairman of the Department of Mental Health Sciences at Hahnemann University School of Medicine ~~(Philadelphia) from 1989-1995.~~in Philadelphia, and most recently a cons ultant in psychiatry at MGH in Boston.

Directors’ Service Contracts

Our Chief Executive Officer. On September 21, 2007, we entered into an agreement with Mr. Geoffrey Kempler, the Chairman of our Board of Directors, in connection with his employment as our Chief Executive Officer. For details regarding the agreement with Mr. Kempler, including benefits upon termination of his employment, see Item 6.B. “Operating and Financial Review and Prospects –- Compensation.”

Other. Except as described above, there are no arrangements or understandings between us and any of our subsidiaries, on the one hand, and any of our directors, on the other hand, providing for benefits upon termination of their employment or service as directors of our company or any of our subsidiaries.

Indemnification of Directors and Officers

Our Constitution provides that, subject to the Australian Corporations Act, every director, secretary, manager or officer of our company or any person employed by our company as auditor shall be indemnified out of our funds against all liability incurred by such person as a director or officer in defending proceedings, whether civil or criminal, in which judgment is given in the persons favor or in which the person is acquitted in connection with any application under the Australian Corporations Act in which relief is granted to the person by a Court.

Under our Constitution no director, auditor or other officer shall be liable for (i) any acts, receipts, neglect or defaults of any other director or officer for joining in any receipt or other act for conformity; (ii) any loss or expense that may happen to us through the inefficiency or deficiency of title to any property acquired by order of the directors or on our behalf; (iii) the inefficiency or deficiency of any security in or upon which any of our monies shall be invested; (iv) any loss or damage arising from bankruptcy, insolvency or tortuous act of any person with whom any monies, securities or effects shall be deposited; (v) any loss occasioned by any error of judgment, omission, default or oversight on the persons part; or (vi) any other loss damage or misfortune whatsoever which shall happen in relation to those things unless the same shall happen through the persons own negligence, default, breach or duty, breach of trust or dishonesty.

In addition, our Constitution provides that to the extent permitted by law, we may pay, or agree to pay, a premium in respect of a contract insuring a person who is liable or has been an officer of our company or one of our subsidiaries against a liability:

—·

incurred by the person in his or her capacity as an officer of our company or a subsidiary of our company provided that the liability does not arise out of a conduct involving a willful breach of duty in relation to our company or a subsidiary of our company; or

—·

for costs and expenses incurred by that person defending proceedings, whatever their outcome.

We maintain a directors’ and officers’ liability insurance policy. We have established a policy for the indemnification of our directors and officers against certain liabilities incurred as a director or officer, including costs and expenses associated in successfully defending legal proceedings.

D.	~~EMPLOYEES~~Employees

At June 30, 2010, we had 12 employees. Of such employees, eight persons were employed in research and development, two persons in management and administration and two persons in operations. All such employees were located in Australia.

At June 30, 2009, we had 12 employees. Of such employees, seven persons were employed in research and development, three persons in management and administration and two persons in operations. All such employees were located in Australia.

At June 30, 2008, we had 13 employees. Of such employees, eight persons were employed in research and development, three persons in management and administration and two persons in operations. All such employees were located in Australia.

At June 30, 2007, we had nine employees. Of such employees, three persons were employed in research and development, four persons in management and administration and two persons in operations. All such employees were located in Australia.

Australian labor laws and regulations are applicable to all of our employees. The laws concern various matters, including severance pay rights at termination, retirement or death, length of work day and work week, minimum wage, overtime payments and insurance for work-related accidents.

E.	~~SHARE OWNERSHIP~~Share Ownership

Beneficial Ownership of Executive Officers and Directors

The following table sets forth certain information as of ~~September 21, 2009~~October 31, 2010 regarding the beneficial ownership of our ordinary shares by each of our directors and executive officers and by all of our directors and executive officers as a group:

Name
Number of Ordinary Shares
Beneficially Owned (1)
Percentage of
Ownership (2)

Geoffrey P. Kempler 19,055,000 (3)(4) 8.11 %
Richard Revelins 370,308 (5)(6) *
Dianne Angus 1,944,837 (7)(8) *
Peter Marks 693,111 (9)(10) *
Brian D. Meltzer 976,666 (11)(12) *
George W. Mihaly 876,666 (13)(14) *
All directors and executive
officers as a group (six
persons) 23,916,588 (15) 10.1 %

Name	Number of Ordinary Shares Beneficially Owned (1)			Percentage of Ownership (2)
Geoffrey P. Kempler		18,055,000	(3)		7.43	%
Richard		370,308	(4)		*
Dianne Angus		2,237,093	(5)		*
Paul Marks		9,291,115	(6)		3.83	%
Peter Marks		393,111	(7)		*
Brian D. Meltzer		676,666	(8)		*
George W. Mihaly		576,666	(9)		*
All directors and executive officers as a group (seven persons)		31,599,959	(10)		12.79	%

__________________

* Less

Less than 1%

Beneficial ownership is determined in accordance with the rules of the Securities and Exchange Commission, and generally includes voting or investment power with respect to securities. Ordinary shares relating to options currently exercisable or exercisable within 60 days of the date of the above table are deemed outstanding for computing the percentage of the person holding such securities but are not deemed outstanding for computing the percentage of any other person. Except as indicated by footnote, and subject to community property laws where applicable, the persons named in the table above have sole voting and investment power with respect to all shares shown as beneficially owned by them.

The percentages shown are based on ~~232,945,639~~242,037,203 ordinary shares issued and outstanding as of ~~September 21, 2009.~~October 31, 2010.

Includes (i) 17,055,000 outstanding ordinary shares, of which 30,000 ordinary shares are held ~~directly~~of record by Mr. Kempler, 13,965,000 ordinary shares are held by Baywick Pty Ltd., an Australian corporation owned by Mr. Kempler, 90,000 ordinary shares are held of record by Crystal Triangle Pty Ltd., an Australian corporation owned by Mr. Kempler and 2,970,000 ordinary shares are held of record by NRB Developments Pty Ltd., an Australian corporation in which Mr. Kempler holds a 50% interest. Mr. Kempler may be deemed to be the beneficial owner of the ordinary shares held ~~directly~~of record by Baywick Pty Ltd., Crystal Triangle Pty Ltd. and NRB Developments Pty Ltd.

Includes 2,000,000 ordinary shares issuable upon the exercise of options for nil consideration, all of which were granted under the 2004 ASX Plan (as defined below). Of such options (i) options to purchase 1,000,000 ordinary shares are exercisable on or before June 30, 2010. Such options may not be exercised unless the price of our ordinary shares has achieved and maintained a minimum value of A$1.00 for five consecutive trading days;; and (ii) options to purchase 1,000,000 ordinary shares ~~are~~ exercisable on or before October 31, 2010 at a price of A$0.30 per share. The options were granted under the 2004 ASX Plan (as defined below).

5.4.

Includes (i) 20,308 outstanding ordinary shares ~~all~~held of ~~which are held~~record by Darontack Pty Ltd., an Australian corporation owned by Mr. ~~Revelins.~~

~~Includes~~Revelins; and (ii) options to purchase 350,000 ordinary shares ~~all~~held of ~~which were granted under the 2004 ASX Plan (as defined below).~~record by Mr. Revelins’ spouse. The options are exercisable on or before October 31, 2010 at a price of A$0.30 per share and ~~are held by Mr. Revelins’ spouse.~~

~~Of such shares, 250,000 ordinary shares are held directly by Ms. Angus.~~

~~Includes options to purchase 1,694,837 ordinary shares, all of which~~ were granted under the 2004 ASX Plan (as defined below).

Includes (i) 250,000 outstanding ordinary shares; and (ii) options to purchase 1,987,093 ordinary shares. Of such options, options to purchase 1,444,837 ordinary shares are exercisable for nil consideration on or before August 7, 2014. These options may not be exercised unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.40 for five consecutive trading days. Options to purchase 292,256 ordinary shares are exercisable for A$0.15 consideration on or before March 31, 2014. The remaining options to purchase 250,000 ordinary shares are exercisable for nil consideration on or before October 31, 2010.

~~Of such shares, 43,111 ordinary shares are held by Lampam Pty Ltd, an Australian corporation owned by Mr. Marks.~~

~~10.~~

~~Includes~~ All of the options ~~to purchase 650,000 ordinary shares, all of which~~ were granted under the 2004 ASX Plan (as defined below). ~~Of such options,~~

Includes (i) ~~options to purchase 300,000~~8,589,361 outstanding ordinary shares ~~are exercisable for nil consideration on or before June 30, 2010. Such options may not be exercised unless the price~~held of ~~our ordinary shares has achieved and maintained a minimum value of A$1.00 for five consecutive trading days;~~record by JJ Holdings (Vic) Pty Ltd, an Australian corporation owned by Mr Marks and (ii) options to purchase ~~350,000~~701,754 ordinary shares. Of such options, options to purchase 350, 877 ordinary shares are exercisable on or before October 31, 2010 at a price of A$~~0.30~~0.37 per ~~share.~~

~~11.~~

~~Of such shares, 326,666 ordinary shares are held by RBC Dexia Pty Ltd., a superannuation fund of Mr. Meltzer.~~

~~12.~~

~~Includes~~share, and options to purchase ~~650,000 ordinary shares, all of which were granted under the 2004 ASX Plan (as defined below). Of such options, (i) options to purchase 300,000~~350, 877 ordinary shares are exercisable ~~for nil consideration~~ on or before ~~June~~November 30, ~~2010. Such options may not be exercised unless the~~2010 at a price of ~~our~~A$0.43 per share.

Includes (i) 43,111 outstanding ordinary shares ~~has achieved and maintained a minimum value~~held of ~~A$1.00 for five consecutive trading days;~~record by Lampam Pty Ltd, an Australian corporation owned by Mr. Peter Marks; and (ii) options to purchase 350,000 ordinary ~~shares~~shares. The options are exercisable on or before October 31, 2010 at a price of A$0.30 per ~~share.~~share and were granted under the 2004 ASX Plan (as defined below).

Includes (i) 326,666 outstanding ordinary shares held of record by RBC Dexia Pty Ltd., a superannuation fund of Mr. Meltzer; and (ii) options to purchase 350,000 ordinary shares. The options are ~~held in escrow for one year from~~exercisable on or before October 31, 2010 at a price of A$0.30 per share and were granted under the ~~date of grant.~~2004 ASX Plan (as defined below).

~~13.~~9.

~~Of such~~Includes (i) 222,666 outstanding ordinary shares, of which 166,666 ordinary shares are held ~~directly~~of record by Dr. Mihaly, 52,000 ordinary shares are held of record by Waide Pty Ltd., an Australian corporation owned by Dr. Mihaly, and 4,000 ordinary shares are held of record by each of Kieren Mihaly and Warwick Mihaly, Dr. Mihaly’s sons. Dr. Mihaly disclaims beneficial ownership of the ordinary shares held by his sons, Kieren Mihaly and Warwick ~~Mihaly.~~

~~14.~~

Includes options to purchase 650,000 ordinary shares, all of which were granted under the 2004 ASX Plan (as defined below). Of such options, (i) options to purchase 300,000 ordinary shares are exercisable for nil consideration on or before June 30, 2010. Such options may not be exercised unless the price of our ordinary shares has achieved and maintained a minimum value of A$1.00 for five consecutive trading days;Mihaly; and (ii) options to purchase 350,000 ordinary ~~shares are~~shares. The options exercisable on or before October 31, 2010 at a price of A$0.30 per ~~share.~~share and were granted under the 2004 ASX Plan (as defined below).

~~15.~~10.

See Footnotes (3) ~~– (14)~~- (9).

Stock Option Plans

In November 2004, we adopted the 2004 Employees’, Directors’ and Consultants’ Share and Option Plan, or the 2004 ASX Plan, and the 2004 American Depository Share (ADS) Option Plan, or the 2004 ADS Plan. For the description below, the 2004 ASX Plan and 2004 ADS Plan are referred to together as the 2004 Plans. Under the 2004 ASX Plan we may issue ordinary shares and under the 2004 ADS Plan we may issue ADSs. We were initially authorized to issue under the 2004 Plans up to an aggregate 12,000,000 ordinary shares or ADSs representing 12,000,000 ordinary shares. In November 2005, our shareholders approved an amendment to the 2004 Plans to provide for the issuance thereunder of an additional 10,000,000 ordinary shares (or ADSs representing 10,000,000 ordinary shares), following ~~which~~whic h we could issue under the 2004 Plans up to an aggregate 22,000,000 ordinary shares or ADSs representing 22,000,000 ordinary shares. In December 2007, our shareholders approved an amendment to the 2004 Plans to provide for the issuance thereunder of an additional 8,000,000 ordinary shares (or ADSs representing 8,000,000 ordinary shares), following which we ~~may~~could issue under the 2004 Plans up to an aggregate 30,000,000 ordinary shares or(or ADSs representing 30,000,000 ordinary ~~shares.~~shares). In November 2008, our shareholders approved an amendment to the 2004 Plans to provide for the issuance thereunder of an additional 15,000,000 ordinary shares (or ADSs representing 15,000,000 ordinary shares), following which we ~~may~~could issue under the 2004 Plans up to an aggregate 45,000,000 ordinary shares or(or ADSs representing 45,000,000 ordinary ~~shares.~~shares). In November 2009, our shareholders approved an amendment to the 2004 Plans to provide for the issuance thereunder of an additional 15,000,000 o rdinary shares (or ADSs representing 15,000,000 ordinary shares), following which we are entitled to issue under the 2004 Plans up to an aggregate 60,000,000 ordinary shares (or ADSs representing 60,000,000 ordinary shares). Any increase in such maximum number of ordinary shares or ADSs issuable under the 2004 Plans is subject to shareholder approval.

2004 ASX Plan. The purpose of the 2004 ASX Plan is to promote the interest of our company and the interest of the employees, directors and consultants of our company and its subsidiaries. Under the 2004 ASX Plan, we may issue to employees, directors and consultants of our company and its subsidiaries, from time to time, ~~up to an aggregate 45,000,000~~ ordinary shares, either by issuance of ordinary shares or under options to purchase ordinary shares granted under the 2004 ASX Plan.

The 2004 ASX Plan is administered by the Share Plan Committee, a sub-committee of the Remuneration Committee. For the purpose of the disclosure below, the term “Remuneration Committee” shall refer to the Remuneration Committee or Share Plan Committee, as applicable. Subject to Board approval where required by applicable law, the Remuneration Committee has the authority, in its sole discretion, to grant options under the 2004 ASX Plan, to interpret the provisions of the 2004 ASX Plan and to prescribe, amend, and rescind rules and regulations relating to the 2004 ASX Plan or any issue or grant thereunder as it may deem necessary or advisable, subject to any other approval if required by applicable law. All decisions made by the Remuneration Committee pursuant to the provisions of the 2004 ASX ~~Plan~~Pl an will be final, conclusive and binding on all persons.

The number of shares issued or options granted, the exercise price and option term or options granted, the vesting schedule and escrow periods of shares issued and options granted, under the 2004 ASX Plan are determined by the Remuneration Committee, in accordance with the provisions of the ASX Plan, and specified in an offer document from our company and accepted by the eligible person, subject to the terms of the 2004 ASX Plan. Options granted under the 2004 ASX Plan will be unlisted and exercisable at an exercise price equal to less than market value of an ordinary share on the ASX at the date of grant, or such other exercise price that the Remuneration Committee determines to be appropriate under the circumstances. The term of an option granted under the 2004 ASX Plan will be determined by the Remuneration ~~Committee,~~Commi ttee; however, no option will be exercisable after the expiration of ten years from the date of its grant. Except as otherwise provided in the 2004 ASX Plan or determined by the Remuneration Committee and set forth in an offer document, the issuance of shares and exercise of options granted under the 2004 ASX Plan will either (i) be subject to an escrow, under which such shares or options cannot be disposed of or exercised, respectively, within six months from the date of issue or grant (or 12 months if issued or granted to a director); or (ii) will vest over a four year period in four equal installments, 25% at the end of each year from the date of grant. Shares issued and options granted under the 2004 ASX Plan may be subject to other performance criteria and hurdles, as determined by the Remuneration Committee.

2004 ADS Plan.The purpose of the 2004 ADS Plan is to promote the interests of our company and non-Australian based employees, officers, consultants, independent contractors and directors. Options granted under the 2004 ADS Plan may be incentive stock options, as provided in Section 422 of the Internal Revenue Code of 1986, as amended, or the Code, or non-qualified stock options. Incentive stock options may only be granted to employees of our company and its subsidiaries (including, without limitation, officers and directors who are also employees of our company and its subsidiaries) and may not be granted to any owner of 10% or more of the total combined voting power of all classes of stock of our company and subsidiaries, or a ~~10%~~1 0% Holder. To the extent that the aggregate fair market value, determined on the date that an option is granted, of ADSs, with respect to which incentive stock options are exercisable for the first time by an optionee during any calendar year exceeds US$100,000, such option shall be treated as a non-qualified stock option.

Under the 2004 ADS Plan, we may grant to employees, officers, consultants, independent contractors and directors of our company or any of its subsidiaries, from time to time, options to purchase ADSs representing ~~up to 45,000,000 of~~ our ordinary shares. The number of ADSs with respect to which options may be granted to any employee under the 2004 ADS Plan in any calendar year shall not exceed 500,000 ADSs (representing 5,000,000 of our ordinary shares)~~.ADSs~~. ADSs that are forfeited under the terms of the 2004 ADS Plan and ADSs that are the subject to options that expire unexercised or which are otherwise surrendered by an optionee without receiving any payment or other benefit with respect to such option may again become available for new option grants under the 2004 ADS Plan.

The 2004 ADS Plan is administered by our Share Plan Committee. Subject to Board approval where required by applicable law, the Remuneration Committee has authority, in its sole discretion, to grant options under the 2004 ADS Plan, to interpret the provisions of the 2004 ADS Plan and to prescribe, amend, and rescind rules and regulations relating to the 2004 ADS Plan or any options granted thereunder as it may deem necessary or advisable, subject to any other approval if required by applicable law. All decisions made by the Remuneration Committee pursuant to the provisions of the 2004 ADS Plan shall be final, conclusive and binding on all persons.

The type of option (incentive stock option or non-qualified stock option), exercise price, option term and vesting schedule of options granted under the 2004 ADS Plan are determined by the Remuneration Committee, in accordance with the provisions of the ADS Plan, and specified in an option agreement by and between our company and the optionee, subject to the terms of the 2004 ADS Plan. The exercise price per each ADS will be determined by the Remuneration Committee at the time any option is granted, however the exercise price of an incentive stock option will not be less than 100% of the fair market value of such ADS on the date of the grant and the price of an incentive stock option granted to a 10% Holder will not be less than 110% of the fair market value of such ADS on the date of the grant. Options granted ~~under~~unde r the 2004 ADS Plan will not be exercisable after the expiration of ten years from the date of grant, and in the case of an incentive stock option granted to a 10% Holder, the term of the option will be five years from the date of grant or such shorter term as may be provided in the option agreement. The options will vest over a four year period in four equal installments, 25% at the end of each year from the date of grant, unless otherwise provided by the Remuneration Committee in an option agreement.

Options granted under the 2004 ADS Plan are not assignable or transferable by the grantee, other than by will or the laws of descent and distribution, and may be exercised during the lifetime of the grantee only by the grantee or his guardian or legal representative.

A summary of the status of the 2004 Plans as of June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, and changes during the years ended on those dates, is presented below:

As of June 30,
2009
2008
2007
Amount
Weighted
average
exercise
price
Amount
Weighted
average
exercise
price
Amount
Weighted
average
exercise
price

Options outstanding at the beginning of
   the year 13,987,848 $ 0.20 13,728,262 $ 0.20 8,727,500 $ 0.36
   Granted 3,099,818 $ 0.32 4,753,149 $ 0.18 5,908,762 -
   Exercised (816,483 ) $ 0.14 (1,393,563 ) (758,000 ) -
   Expired - - (1,100,000 ) $ 0.50

   Forfeited - - (2,000,000 ) (150,000 ) -

Options outstanding at the end of the
   year 16,271,183 $ 0.25 13,987,848 $ 0.20 13,728,262 $ 0.20

Options exercisable at the end of the
   year 11,198,846 $ 0.36 9,974,332 $ 0.31 5,940,000 $ 0.47

Options that may be granted as of the end
   of the year 23,652,332 14,152,150 6,484,049

	As of June 30,
	2010					2009					2008
	Amount			Weighted average exercise price		Amount			Weighted average exercise price		Amount			Weighted average exercise price
Options outstanding at the beginning of the year		16,271,183		$	0.25		13,987,848		$	0.20		13,728,262		$	0.20
Granted		2,204,609		$	0.10		3,099,818		$	0.32		4,753,149		$	0.18
Exercised		(420,398	)		--		(816,483	)	$	0.14		(1,393,563	)
Expired		(2,200,000	)		--		--			--		(1,100,000	)	$	0.50
Forfeited		--			--		--			--		(2,000,000	)

Options outstanding at the end of the year		15,855,394		$	0.26		16,271,183		$	0.25		13,987,848		$	0.20

Options exercisable at the end of the year		12,277,204		$	0.34		11,198,846		$	0.36		9,974,332		$	0.31

Options that may be granted as of the end of the year		42,850,233					23,652,332					14,152,150

In addition, as of June 30, ~~2009, 2,108,439~~2010, 165,000 ordinary shares have been issued under the ASX Plan that were not issued upon the exercise of options.

ITEM 7.

MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS

A.	~~MAJOR SHAREHOLDERS~~Major Shareholders

The following table sets forth certain information, as of ~~September 21, 2009,~~October 31, 2010, regarding the beneficial ownership by all shareholders known to us to own beneficially more than 5% of our ordinary shares.

Name
Number of Ordinary Shares
Beneficially Owned (1)
Percentage of
Outstanding Ordinary
Shares (2)

BAM Opportunity Fund, L.P. 30,000,000 (3) 12.88 %
Geoffrey P. Kempler 19,055,000 (4)(5) 8.11 %
Jagen Nominees Pty Ltd. 15,689,172 (6) 6.73 %
Balyasny Asset Management LP. 12,836,682 (7) 5.51 %

Name	Number of Ordinary Shares Beneficially Owned (1)			Percentage of Outstanding Ordinary Shares (2)
Bank of America Corporation		30,080,000	(3)		12.43	%
Geoffrey P. Kempler		18,055,000	(4)		7.46	%
Jagen Nominees Pty Ltd		15,409,060	(5)		6.37	%
BAM Management, LLC		15,241,193	(6)		6.30	%
Balyasny Asset Management LP		12,836,682	(7)		5.30	%

_______________

(1)

Beneficial ownership is determined in accordance with the rules of the Securities and Exchange Commission and generally includes voting or investment power with respect to securities. Ordinary shares relating to options currently exercisable or exercisable within 60 days of the date of the table above are deemed outstanding for computing the percentage of the person holding such securities but are not deemed outstanding for computing the percentage of any other person. Except as indicated by footnote, and subject to community property laws where applicable, the persons named in the table above have sole voting and investment power with respect to all shares shown as beneficially owned by them.

(2)	The percentages shown are based on ~~232,945,639~~242,037,203 ordinary shares issued and outstanding as of ~~September 21, 2009.~~October 31, 2010.

(3)

Based solely upon, and qualified in its entirety with reference to a ~~Schedule 13G~~Notice of Initial Substantial Holder filed by ~~BAM Opportunity Fund, L.P., or BAM Partnership,~~Bank of America Corporation with the ~~Securities and Exchange Commission~~ASX on September ~~15,~~18, 2009. The Schedule 13G indicates that BAM Capital, LLC, or BAM Capital, which serves as the general partner of BAM Partnership, and BAM Management, LLC, or BAM Management, which serves as the investment manager to BAM Partnership, have discretionary trading authority over the shares held by BAM Partnership. The managing members of BAM Capital and BAM Management are Ross Berman and Hal Mintz, who share investment management duties. Each of BAM Partnership, BAM Capital, BAM Management, Mr. Mintz and Mr. Berman disclaims beneficial ownership of the ordinary shares, except to the extent of such person’s pecuniary interest therein.

(4)

~~(5)~~

Includes option to purchase 2,000,000 ordinary shares, all of which were granted under the 2004 ASX Plan (as defined below). Of such options, (i) options to purchase 1,000,000 ordinary shares are exercisable for nil consideration on or before June 30, 2010. Such options may not be exercised unless the price of our ordinary shares has achieved and maintained a minimum value of A$1.00 for five consecutive trading days;; and (ii) options to purchase 1,000,000 ordinary shares ~~are~~ exercisable on or before October 31, 2010 at a price of A$0.30 per share. The options ~~are held in escrow for one year from~~were granted under the ~~date of grant.~~2004 ASX Plan (as defined below).

~~(6)~~(5)

Based upon a Notice of Change of Interest of Substantial Holder filed by Jagen Nominees Pty Ltd with the ASX on September 16, 2009 and other information available to the company. ~~Includes 280,112 ordinary shares issuable upon the exercise of options exercisable for A$0.446 on or before November 30, 2009 held by Jagen Nominees Pty Ltd.~~ Mr. Boris Liberman is the sole owner of Jagen Nominees Pty Ltd. and may be deemed to hold the voting and investment powers for the ordinary shares held of record by Jagen Nominees Pty Ltd.

(6)

Based solely upon, and qualified in its entirety with reference to, Amendment No. 6 to Schedule 13G filed with the Securities and Exchange Commission on May 18, 2010. The Schedule 13G/A relates to 5,241,193 outstanding ordinary shares held of record by BAM Opportunity Fund, L.P., or BAM Partnership, and options to purchase 10,000,000 ordinary shares held by BAM Opportunity Fund SPV, LLC, or BAM SPV. The Schedule 13G/A indicates that BAM Capital, LLC, or BAM Capital, which serves as the general partner of BAM Partnership, and BAM Management, LLC, or BAM Management, which serves as the investment manager to BAM Partnership, have discretionary trading authority over the shares held by BAM Partnership and that BAM Management has discretionary trading authority over the shares held by BAM SPV. The managing members of BAM Capital and BAM Management are Ross Berman and Hal Mintz. 0;The Schedule 13G/A further indicates the AM Investment Partners, LLC, or AMIP, and it affiliates have entered into an agreement to combine their business with BAM Management and its affiliates. The managing members of AMIP are Adam Stern and Mark Friedman. Each of BAM SPV, BAM Partnership, BAM Capital, BAM Management, AMIP and Messrs. Mintz, Berman, Stern and Friedman disclaims beneficial ownership of the ordinary shares, except to the extent of such person’s pecuniary interest therein.

(7)

Based solely upon, and qualified in its entirety with reference to a Notice of Change of Interest of Substantial Holder filed by Balyasny Asset Management LP with the ASX on May 23, 2008. Balyasny Asset Management LP serves as investment manager to Atlas Master Fund Ltd. Atlas Master Fund Ltd. holds the voting and investment powers for the ordinary shares held by Balyasny Asset Management LP.

Significant Changes in the Ownership of Major Shareholders

Mr. Geoffrey Kempler. As of June 30, 2006, Geoffrey Kempler, the Chairman of our Board of Directors and our Chief Executive Officer, beneficially owned 18,055,000 of our ordinary shares, representing approximately 13.98% of our then outstanding shares. During fiscal 2007, we granted to Mr. Kempler options to purchase 1,000,000 ordinary shares exercisable on or before June 30, 2009. Such options may not be exercised unless the price of our ordinary shares has achieved and maintained a minimum value of A$0.80 for five consecutive trading days. As a result, as of June 30, 2007, Mr. Kempler’s beneficial ownership increased to 19,055,000 ordinary shares, representing approximately 12.57% of our then outstanding shares. During fiscal year 2008, we granted to Mr. Kempler options to purchase 1,000,000 ordinary shares that are exercisable on or before October 31, 2010 at a price of A$0.30 per share. ~~The options were held in escrow for one year from the date of grant.~~ As a result, as of June 30, 2008 and 2009, Mr. Kempler’s beneficially owned 20,055,000 ordinary shares, representing approximately 9.94% and 9.89%, respectively, of our then outstanding shares. On December 1, 2009, Mr Kempler filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 17,055,000 or 7.29% of our then outstanding shares. In addition, Mr. Kempler holds options to purchase 1,000,000 ordinary shares that are exercisable on or before October 31, 2010 at a price of A$0.30 per share.

AMP Ltd.On December 15, 2006, AMP Ltd., or AMP, filed with the ASX a Notice of Initial Substantial Holder, reflecting beneficial ownership of 11,204,482, or 7.78%, of our then outstanding ordinary shares. On August 31, 2007, AMP filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 9,641,383, or 6.36%, of our then outstanding ordinary shares. On November 8, 2007, AMP filed with the ASX a Notice of Ceasing to be a Substantial Holder.

Jagen Nominees Pty Ltd. As of September 27, 2007, Jagen Nominees Pty Ltd., or Jagen, beneficially owned 15,409,060, or 10.17% of our then outstanding ordinary shares. On October 19, 2007, Jagen filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 15,409,060, or 8.89%, of our then outstanding shares. On May 28, 2008, Jagen filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 15,409,060, or 7.15%, of our then outstanding shares. On September 16, 2009, Jagen filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 15,409,060, or 6.61%, of our then outstanding shares.

Balyasny Asset Management ~~L.P..~~L.P. On March 13, 2008, Balyasny Asset Management L.P., or BAM, filed with the ASX a Notice of Initial Substantial Holder, reflecting beneficial ownership of 9,263,507, or 5.06%, of our then outstanding ordinary shares. On May 23, 2008, BAM filed with the ASX a Notice of Change of Interest of Substantial Holder, reflecting ownership of 12,836,682, or 7.00%, of our then outstanding ordinary shares.

BAM Capital. On September 8, 2009, we entered into a private placement agreement with BAM Capital, ~~LLC.~~one of our institutional shareholders in the United States, under which we raised an aggregate A$6.0 million before costs (approximately A$5.7 million net of costs) in a private placement of our ordinary shares to such investor. The private placement was for 30 million ordinary shares (equivalent to three million ADRs) at a price of A$0.20 per share (A$2.0 per ADR). We also agreed to grant the investor, subject to shareholder approval, options to purchase 10 million ordinary shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the pri vate placement. Shareholder approval for the issuance of the shares and option grant was obtained in November 2009. We also agreed to issue to the investor up to an additional 3,000,000 ordinary shares, or 300,000 ADRs, if the daily closing price of our ordinary shares on the ASX on any day from the date of the private placement until five days after the date on which the registration statement for the ordinary shares issued in the private placement is declared effective, declines below A$0.19, based on a formula set forth in the agreement. The foregoing condition was met and based on the agreed upon formula, we issued to the investor an additional 750,000 ordinary shares, pursuant to the approval of our shareholders obtained in November 2009. For additional information, see Item 10.C. “Additional Information - Material Contracts.” On ~~September 15, 2009,~~April 23, 2010, BAM Capital ~~LLC~~ filed with the ASX a Notice of ~~Initial~~Ceasing to be a Substantial ~~Holder, reflecting beneficial ownership of 30,000,000,~~Holder. On May 18, 2010, Amendment No. 6 to Schedule 13G was filed by BAM Capital and other reporting persons with the Securities and Exchange Commission indicating that such persons beneficially hold 15,241,193 or ~~12.88%~~6.25% of our then outstanding ordinary shares, of which 5,241,193 ordinary shares are outstanding and held of record by BAM Partnership and 10,000,000 ordinary shares are subject to options held by BAM SPV. See footnote (6) to the major shareholder above.

Bank of America Corporation. On September 18, 2009, Bank of America Corporation filed a Notice of Initial Substantial Holder with the ASX reflecting ownership of 30,080,000, or 12.29%, of our then outstanding shares.

Morgan Stanley. On November 16, 2009, Morgan Stanley filed a Schedule 13G with the Securities and Exchange Commission reflecting beneficial ownership of 12,076,175, or 5.2% of our ordinary shares. On February 12, 2010, Morgan Stanley filed Amendment No. 1 to Schedule 13G with the Securities and Exchange Commission reflecting beneficial ownership of 11,802,531, or 5% of our ordinary shares. On March 1, 2010, Morgan Stanley filed with the ASX a Notice of Ceasing to be a Substantial Holder.

Major Shareholders Voting Rights

Our major shareholders do not have different voting rights.

Record Holders

As of ~~September21, 2009,~~October 31, 2010, there were ~~2,388~~2,426 holders of record of our ordinary shares, of which 1819 record holders, holding approximately ~~3.45%~~3.53% of our ordinary shares, had registered addresses in the United States. These numbers are not representative of the number of beneficial holders of our shares nor are they representative of where such beneficial holders reside, since many of these ordinary shares were held of record by brokers or other nominees. The majority of trading by our U.S. investors is done by means of ADRs that are held of record by ~~ANZ~~National Nominees Ltd., which held ~~30.28%~~43.54% of our ordinary shares as of such date.

B.	~~RELATED PARTY TRANSACTIONS~~Related Party Transactions

None.

C.	~~INTERESTS OF EXPERTS AND COUNSEL~~Interests of Experts and Counsel

Not applicable.

ITEM 8.

FINANCIAL INFORMATION

A.	~~FINANCIAL STATEMENTS AND OTHER FINANCIAL INFORMATION~~Financial Statements and Other Financial Information

See our consolidated financial statements, including the notes thereto, in Item 18.

Legal Proceedings

~~Our former Chief Executive Officer, who also served as a director, has~~

We are not involved in any legal proceedings nor are we subject to any threatened ~~to initiate a claim against our company arising from his alleged inability to freely transfer shares underlying certain unexercised ADR options previously granted to him pursuant~~litigation that is material to our ~~2004 ADS Plan. We believe, based~~business or financial condition. A contingent liability relating to a past employee matter that was included in our financial statements for the year ended June 30, 2009 and disclosed in our Annual Report on ~~the explicit terms of the 2004 ADS Plan and applicable law and regulations, his allegations to be without merit and we intend to vigorously defend any~~Form 20-F for such ~~claim if formally asserted.~~

period, is no longer deemed material.

Dividend Distribution Policy

We have never paid cash dividends to our shareholders. We intend to retain future earnings for use in our business and do not anticipate paying cash dividends on our ordinary shares in the foreseeable future. Any future dividend policy will be determined by the Board of Directors and will be based upon various factors, including our results of operations, financial condition, current and anticipated cash needs, future prospects, contractual restrictions and other factors as the Board of Directors may deem relevant.

B.	~~SIGNIFICANT CHANGES~~Significant Changes

On September 8, 2009, we entered into a private placement agreement with one of our institutional shareholders in the United States, under which we will raise an aggregate A$6.0 million before costs (approximately A$5.7 million net of costs) in a private placement of our ordinary shares to such investor. Of such amount, A$3.0 million was paid at the closing of the private placement on September 11, 2009 and an additional A$3.0 million will be paid on or before September 30, 2009. The private placement was for 30 million ordinary shares (equivalent to three million ADRs) at a price of A$0.20 per share (A$2.0 per ADR). We also agreed to grant the investor, subject to shareholder approval, options to purchase 10 million ordinary shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the private placement. If shareholder approval is not obtained for the option grant, the options will be granted at such time that shareholder approval is no longer required for the issuance under the rules of the ASX. For additional information regarding the terms of the private placement, see Item 10.C. “Additional Information – Material Contracts.” The proceeds from the private placement will be used to support our research and development programs and to fund our working capital requirements.

~~Other than as described above, there~~

There have been no significant changes in the operation or financial condition of our company since June 30, ~~2009.~~

2010.

ITEM 9.

THE OFFER AND LISTING

A.	~~OFFER AND LISTING DETAILS~~Offer and Listing Details

Australian Stock Exchange

Our ordinary shares have traded on the ASX since our initial public offering on March 29, 2000. The following table sets forth, for the periods indicated, the high and low market quotations for our ordinary shares, as quoted on the ASX.

Per Ordinary Share (A$)
High
Low

Fiscal Year Ended June 30,
2005 0.70 0.13
2006 0.30 0.15
2007 0.80 0.18
2008 0.70 0.23
2009 0.69 0.12

Fiscal Year Ended June 30, 2008:
First Quarter 0.35 0.26
Second Quarter 0.51 0.23
Third Quarter 0.70 0.36
Fourth Quarter 0.48 0.38

Fiscal Year Ended June 30, 2009:
First Quarter 0.53 0.38
Second Quarter 0.50 0.28
Third Quarter 0.38 0.15
Fourth Quarter 0.22 0.12

Month Ended:
March 2009 0.22 0.15
April 2009 0.20 0.17
May 2009 0.22 0.17
June 2009 0.20 0.12
July 2009 0.19 0.14
August 2009 0.25 0.17

	Per Ordinary Share (A$)
	High		Low
Fiscal Year Ended June 30,
2006		0.30		0.15
2007		0.80		0.18
2008		0.70		0.23
2009		0.69		0.12
2010		0.25		0.12

Fiscal Year Ended June 30, 2009:
First Quarter		0.53		0.38
Second Quarter		0.50		0.28
Third Quarter		0.38		0.15
Fourth Quarter		0.22		0.12

Fiscal Year Ended June 30, 2010:
First Quarter		0.25		0.14
Second Quarter		0.24		0.14
Third Quarter		0.17		0.12
Fourth Quarter		0.22		0.12

Fiscal Year Ended June 30, 2011:
First Quarter		0.17		0.12

Month Ended:
May 2010		0.19		0.14
June 2010		0.17		0.12
July 2010		0.17		0.14
August 2010		0.16		0.13
September 2010		0.15		0.12
October 2010		0.14		0.12

NASDAQ Capital Market

Since September 5, 2002 our Level II ADRs have traded on the NASDAQ Capital Market under the symbol “PRAN.” The following table sets forth, for the periods indicated, the high ask and low bid prices of our Level II ADRs on the NASDAQ Capital Market:

Per ADR (US$)
High
Low

Fiscal Year Ended June 30,
2005 5.19 0.98
2006 2.40 1.20
2007 4.35 1.21
2008 6.73 2.06
2009 5.70 1.00

Fiscal Year Ended June 30, 2008:
First Quarter 3.10 2.20
Second Quarter 4.05 2.06
Third Quarter 6.73 3.25
Fourth Quarter 4.45 3.56

Fiscal Year Ended June 30, 2009:
First Quarter 5.70 3.20
Second Quarter 3.50 1.30
Third Quarter 3.11 1.00
Fourth Quarter 1.75 1.14

Month Ended:
March 2009 1.65 1.00
April 2009 1.75 1.33
May 2009 1.60 1.14
June 2009 1.48 1.20
July 2009 1.80 1.05
August 2009 2.17 1.45

	Per ADR (US$)
	High		Low
Fiscal Year Ended June 30,
2006		2.40		1.20
2007		4.35		1.21
2008		6.73		2.06
2009		5.70		1.00
2010		3.35		1.02

Fiscal Year Ended June 30, 2009:
First Quarter		5.70		3.20
Second Quarter		3.50		1.30
Third Quarter		3.11		1.00
Fourth Quarter		1.75		1.14

Fiscal Year Ended June 30, 2010:
First Quarter		2.17		1.05
Second Quarter		1.89		1.13
Third Quarter		1.60		1.02
Fourth Quarter		3.35		1.09

Fiscal Year Ended June 30, 2011:
First Quarter		1.38		1.09

Month Ended:
May 2010		1.82		1.28
June 2010		1.59		1.09
July 2010		1.38		1.09
August 2010		1.34		1.10
September 2010		1.25		1.11
October 2010		1.50		1.13

B.	~~PLAN OF DISTRIBUTION~~Plan of Distribution

Not applicable.

C.	~~MARKETS~~Markets

The principal listing of our ordinary shares and listed options to purchase ordinary shares is on the ASX. As of April 5, 2002, our ADRs were eligible to trade on the NASDAQ Capital OTC Bulletin Board in the United States and since September 5, 2002, our ADRs have traded on the NASDAQ Capital Market under the symbol “PRAN.” We entered into a Deposit Agreement with the Bank of New York under which the Bank of New York, acting as depositary, issues ADRs, each of which evidences an ADS, which in turn represents ten of our ordinary shares.

D.	~~SELLING SHAREHOLDERS~~Selling Shareholders

Not applicable.

E.	~~DILUTION~~Dilution

Not applicable.

F.	~~EXPENSES OF THE ISSUE~~Expenses of the Issue

Not applicable.

ITEM 10.

ADDITIONAL INFORMATION

A.	~~SHARE CAPITAL~~Share Capital

Not applicable.

B.	~~MEMORANDUM AND ARTICLES OF ASSOCIATION~~Memorandum and Articles of Association

We were registered on November 11, 1997 as Prana Pty Ltd and on November 26, 1999 we converted to a public company and changed our name to Prana Corporation Ltd. On January 1, 2000, we changed our name to Prana Biotechnology Ltd. Our registration number is ACN 080699065.

Prana’s Purposes and Objects

As a public company we have all the rights, powers and privileges of a natural person. Our Constitution does not specify any purposes or objects.

The Powers of the Directors

Under the provisions of our Constitution our directors may exercise all of the powers of our company, other than those that are required by our Constitution or the Corporations Law of Australia to be exercised at a general meeting of shareholders. A director may participate in a meeting and vote on a proposal, arrangement or contract in which he or she is materially interested, so long as the director’s interest is declared in accordance with the Corporations Law. The authority of our directors to enter into borrowing arrangements on our behalf is not limited, except in the same manner as any other transaction by us.

Rights Attached to Our Ordinary Shares

The concept of authorized share capital no longer exists in Australia and as a result, our authorized share capital is unlimited. All our outstanding ordinary shares are validly issued, fully paid and non-assessable. The rights attached to our ordinary shares are as follows:

Dividend rights.If our board of directors recommends a dividend, registered holders of our ordinary shares may declare a dividend by ordinary resolution in a general meeting. The dividend, however, cannot exceed the amount recommended by our board of directors. Our board of directors may declare an interim dividend. No dividend may be paid except out of our profits.

Voting rights. Holders of ordinary shares have one vote for each ordinary share held on all matters submitted to a vote of shareholders. Such voting rights may be affected by the grant of any special voting rights to the holders of a class of shares with preferential rights that may be authorized in the future.

The quorum required for an ordinary meeting of shareholders consists of at least two shareholders represented in person or by proxy who hold or represent, in the aggregate, at least one third of the voting rights of the issued share capital. A meeting adjourned for lack of a quorum generally is adjourned to the same day in the following week at the same time and place or any time and place as the directors designate in a notice to the shareholders. At the reconvened meeting, the required quorum consists of any two members present in person or by proxy.

An ordinary resolution, such as a resolution for the declaration of dividends, requires approval by the holders of a majority of the voting rights represented at the meeting, in person, by proxy or by written ballot and voting thereon. Under our Constitution, a special resolution, such as amending our Constitution, approving any change in capitalization, winding-up, authorization of a class of shares with special rights, or other changes as specified in our Constitution, requires approval of a special majority, representing the holders of no less than 75% of the voting rights represented at the meeting in person, by proxy or by written ballot, and voting thereon.

Pursuant to our Constitution, our directors are elected at our annual general meeting of shareholders by a vote of the holders of a majority of the voting power represented and voting at such meeting.

Rights in our profits. Our shareholders have the right to share in our profits distributed as a dividend and any other permitted distribution.

Rights in the event of liquidation. In the event of our liquidation, after satisfaction of liabilities to creditors, our assets will be distributed to the holders of ordinary shares in proportion to the nominal value of their holdings. This right may be affected by the grant of preferential dividend or distribution rights to the holders of a class of shares with preferential rights that may be authorized in the future.

Changing Rights Attached to Shares

According to our Constitution, in order to change the rights attached to any class of shares, unless otherwise provided by the terms of the class, such change must be adopted by a general meeting of the shareholders and by a separate general meeting of the holders of the affected class with a majority of 75% of the voting power participating in such meeting.

Annual and Extraordinary Meetings

Our Board of Directors must convene an annual meeting of shareholders at least once every calendar year, within five months of our last fiscal year-end balance sheet data. Notice of at least twenty-eight (28) days prior to the date of the meeting is required. An extraordinary meeting may be convened by the board of directors, it decides or upon a demand of any directors, or of one or more shareholders holding in the aggregate at least five percent (5%) of our issued capital. An extraordinary meeting must be called not more than twenty-one (21) days after the request is made. The meeting must be held not later than two months after the request is given.

Limitations on the Rights to Own Securities in Our Company

Neither our Constitution nor the laws of the Commonwealth of Australia restrict in any way the ownership or voting of our shares.

Changes in Our Capital

Pursuant to the Listing Rules of the Australian Stock Exchange, our directors may in their discretion ~~allow~~issue securities equal to not more than 15% of our issued capital within a 12-month period. ~~Other allotments~~Issuances of securities ~~requiring~~in excess of such amount require the approval of our shareholders by an ordinary ~~resolution of shareholders.~~

resolution.

C.	~~MATERIAL CONTRACTS~~Material Contracts

See the patents and license agreements described under Item 4.B. “Information on the Company –- Business Overview –- Patents and License Agreements.”

On December 1, 2000, we entered into a research funding and intellectual property assignment agreement with the University of Melbourne, under which the University of Melbourne agreed to conduct certain research projects on our behalf. Such projects include structure-based drug design involving the design of various metal-based compounds as potential diagnostics and therapeutics, drug screening and development involving the characterization of our compoundsin vitro andin vivo models of neurodegenerative disorders, and cell-based drug discovery involving the screening and assessment of our compounds in cell-based systems to measure toxicity and cellular dysfunction and to develop new screens for our company. In consideration of such services, we agreed to pay the University of Melbourne a sum of A$297,000 (inclusive of goods and services tax) each year for a period of three years. In consideration for the assignment of rights to intellectual property developed by the University of Melbourne during the research period, we agreed to pay to the University of Melbourne royalties equal to 1.5% of the net invoice price of all products incorporating such intellectual property sold by us or on our behalf, or, the lesser of 1.5% of the net invoice price of such products sold by a licensee or assignee and 10% of gross revenues received from licensees or assignees relating to the exploitation of such intellectual property. Following the expiration of this agreement, the parties entered into a second research funding and intellectual property assignment agreement, which is deemed to have commenced as of the expiration date of the previous agreement on December 1, 2003 and expired on December 1, ~~2006.~~2 006. Following the expiration of this second agreement, the parties entered into a third research funding and intellectual property assignment agreement, which is deemed to have commenced as of the expiration date of the previous agreement on December 1, 2006 and expires on December 1, 2009. The financial consideration terms under the original agreement remain unchanged by the second and third research funding and intellectual property assignment agreements. Under the terms of the second and third research funding and intellectual property assignment agreements an annual budget is set for each of the three years of each respective agreement. We provided to the University of Melbourne funding in an amount equal to A$~~690,500 (exclusive of goods and service tax) for the year running December 2006 to November 2007 and A$~~704,000 for the year running December 2007 to November ~~2008.~~2008 and A$529,000 for the year running December 2008 to November 2009. We estimate that we will provide to the University of Melbourne funding in an amount equal to A$~~564,000~~363,500 (exclusive ofo f goods and services tax) for the year running December ~~2008~~2009 to November ~~2009.~~2010.

On January 8, 2004, we entered into a ten year consultancy services agreement with Professor Ashley Bush, effective as of February 1, 2003. The consulting services provided by Professor Ashley Bush include the discussion of current and future developments in the field of therapies based on metal mediated, oxidative stress or toxic gain of function of proteins involved in selected neurodegenerative diseases. His services also include possible participation in research projects, the assignment of intellectual property rights arising from such projects and assisting is with our patent prosecutions. The services are provided for a maximum of 40 days per year of service under the agreement. Under the agreement, we agreed to pay Professor Bush a consulting fee of US$100,000 per year, increasing on ~~the~~th e anniversary of the agreement by the U.S. consumer price index, which effective June 1, ~~,2009~~2009, was reduced to AU$60,000 per year, increasing on the anniversary of the agreement by the Australian consumer price index. We also agreed, as a bonus package, to issue to Professor Bush 1,650,000 ordinary shares and to grant to him options to purchase 825,000 ordinary shares at an exercise price of A$0.50 per share. The shares and options vest in four equal installments on each of the six months anniversaries following the effective date of the agreement. In addition, subject to the achievement of certain milestones, Professor Bush is entitled to purchase up to 5,000,000 additional ordinary shares at a price per share that is 10% below the mean market price of our ordinary shares during the 30-day period prior to their purchase. Once a milestone has been achieved, up to 250,000 ordinary shares out of the total tranche of ordinary shares to which he becomes entitled may be purchased each six months after such achievement. The first milestone has been achieved (the publication of results of a Phase II trial) and as ~~such,~~a result, Professor Bush is now entitled to purchase up to 1,250,000 ordinary shares in accordance with the foregoing terms, of which Professor Bush acquired 250,000 ordinary shares during the 2007 fiscal year. The ordinary shares issued and options granted to Professor Bush under the agreement are subject to certain resale restrictions. During the period of 20 years after the effective date of the agreement, Professor Bush is also entitled to receive royalties equal to 5% of the income that we derive from the exploitation of new intellectual property developed by him or contributed to our company though his services pursuant to the agreement. Initially, the agreement provided that it could be terminated for any reason by either party upon 90 days prior notice, which period was reduced to 30 days as of November 14, 2007.

On July 28, 2004, we and The General Hospital Corporation of Massachusetts settled all outstanding litigation with P.N. Gerolymatos S.A., or P.N.G., regarding the exploitation rights to certain patents relating to pharmaceutical compositions and uses of clioquinol, or PBT1. Pursuant to the settlement agreement, all patent oppositions in Europe and Australia were withdrawn and the law suits then pending before the U.S. District Court for the District of Columbia and the Court of Athens in Greece were dismissed. Under the settlement agreement, we and P.N.G. agreed to recognize the rights of each other to develop clioquinol in our respective territories. As a result of the settlement agreement, we now hold the rights to selected uses of clioquinol and pharmaceutical compositions in the United States and ~~selected~~sele cted uses of clioquinol in Japan, and P.N.G. holds certain patent rights on the uses of clioquinol for Europe and other territories. Under the settlement agreement, we issued 1,350,000 of our ordinary shares to P.N.G. (which were held in escrow for 12 months), and made a payment of US$150,000 to P.N.G. Such settlement in the total value of A$971,764 was expensed in fiscal year 2004. Under the settlement agreement we also agreed to pay a sales royalty to P.N.G. on sales of PBT1 in the United States and Japan and we are entitled to receive a percentage of P.N.G.‘s’s income on sales of PBT1 in the other territories. In April 2005, we announced our decision not to proceed with the PBT1 study. P.N.G. is also entitled to receive 2% of our worldwide income from PBT2 and any other future clioquinol derivative.

In November 2006, we entered into a general services agreement with Quintiles Limited, a clinical research organization, to perform services relating to the conduct of the Phase IIa PBT2 clinical trial, including site initiation, patient screening and monitoring, data analysis, investigator meetings, statistical analysis and clinical trial reporting. We paid Quintiles Limited US$140,003, US$2,287,306 million and US$874,135 million for fiscal years 2009, 2008 and 2007, respectively.

On May 22, 2007, we entered into an agreement with Patheon Inc., or Patheon, to undertake the capsule formulation development and prospective clinical trial manufacturing of PBT2 into capsules to support prospective further development of PBT2 into a Phase IIb study and/or other secondary clinical applications of PBT2. During the 2008 fiscal year, Patheon undertook the development of a capsule formulation suitable for large scale manufacture, as well as the development and validation of analytical methods to release the capsules. During the 2009 fiscal year, Patheon manufactured a feasibility batch of capsules using the newly developed process. We paid Patheon US$296,551, US$238,737 and US$259,372 for ~~fiscals~~the fiscal years 2010, 2009 and 2008, respectively, for services provided under the agreement.

In June 2007, we entered into two GMP drug manufacture and laboratory development agreements with the Institute for Drug Technology Australia Limited, or IDT, to undertake the GMP manufacture of an initial 4kg batch and subsequent large scale manufacture of 30kg of PBT2. IDT is engaged to also undertake process development, quality control release testing and stability testing of the final drug product before its release. We paid IDT A$18,635, A$11,442 and A$1,147,272 for ~~fiscals year~~the fiscal years 2010, 2009 and 2008, respectively, for services provided under the two agreements.

In December 2008, we entered into a process development and manufacturing agreement with Dr. Reddy’s Laboratories Limited, or Dr. Reddy’s, to enable the transfer of existing manufacturing methods for PBT2 to Dr. Reddy’s to work on improving the route of manufacture, optimization and scale up manufacture of PBT2. The agreement is comprised of a series of independent sub-projects, each of which is subject to our prior authorization to be initiated and funded, at our sole discretion. At this time, our committed expenditure for authorized sub-projects is US$~~175,500. If all sub-projects are initiated and completed, the total funding under the agreement will be approximately US$1.4 million.~~1,125,000. The term of the agreement is for 90 days post the receipt by us of a written report and/or manufacturing deliverables under the last approved sub-project under the agreement. Early termination is available to either party under specified conditions, including material breach and voluntary termination by either party upon 30 days written notice.

We paid Dr. Reddy’s US$175,500 and US$82,500 for the fiscal years 2010 and 2009, respectively, for services provided under the agreement.

On September 8, 2009, we entered into a private placement agreement with BAM Capital LLC, one of our institutional shareholders in the United States, under which ~~we will raise~~raised an aggregate A$6.0 million before costs (approximately A$5.7 million net of costs) in a private placement of our ordinary shares to such investor. Of such amount, A$3.0 million was paid at the closing of the private placement on September 11, 2009 and an additional A$3.0 million ~~will be~~was paid on ~~or before~~ September ~~30,~~29, 2009. The private placement was for 30 million ordinary shares (equivalent to three million ADRs) at a price of A$0.20 per share (A$2.0 per ADR). We also agreed to grant the investor, subject to shareholder approval, options to purchase 10 million ordinary shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the private placement. ~~If shareholder~~Shareholder approval ~~is not obtained for the option grant, the options will be granted at such time that shareholder approval is no longer required~~ for the issuance ~~under the rules~~ of the ASX. If within 45 days of the private placement, we issue ordinary shares to a third party at a price that is less than $A0.20, the investor is entitled, for no additional consideration, to additional ordinary shares so as to reduce the average price of the ordinary shares and ~~options issued~~option grant was obtained in ~~the private placement and the additional ordinary shares being issued to the investor to the price per share paid by the third party.~~November 2009. We also agreed to promptly take steps to register the ADRs with respect to the ordinary shares issued for distribution from time to time by the investor, and after January 1, 2010, upon the investor’s demand, to file a registration statement covering the shares underlying the options. ~~The~~We also agreed to issue to the investor ~~is also entitled to~~ up to an additional 3,000,000 ordinary shares, or 300,000 ADRs, if the daily closing price of our ordinary shares on the ASX on any day from the date of the private placement until five days after the date on which the registration statement for the ordinary shares issued in the private placement is declared effective, declines below A$0.19, based on a formula set forth in the agreement.

The foregoing condition was met, and based o n the agreed upon formula, we issued to the investor an additional 750,000 ordinary shares, pursuant to the approval of our shareholders obtained in November 2009.

On June 23, 2010, we entered into an agreement with Quintiles in connection with a research and development contract that we had previously entered into with Quintiles. Under the agreement, Quintiles agreed to pay to us US$2.0 million, of which US$1,137,500 has been paid and the remaining US$862,500 will be paid in three equal installments on October 1, 2010, January 5, 2011, and March 1, 2011. In addition, we agreed to issue to Quintiles 7,064,749 of our ordinary shares at a price per share of A$0.1624 ($US1.62), or an aggregate purchase price of A$1.15 million (US$1.0 million), which issuance was completed on July 1, 2010. Quintiles also agreed that in the event that we consummate a qualified financing (as such term is defined in the agreement) within one year after the date of the agreement, it will pu rchase from us additional ordinary shares for an aggregate purchase price of US$1.0 million, on the same terms and conditions as the qualified financing.

D.	~~EXCHANGE CONTROLS~~Exchange Controls

Australia has largely abolished exchange controls on investment transactions. The Australian dollar is freely convertible into U.S. dollars. In addition, there are currently no specific rules or limitations regarding the export from Australia of profits, dividends, capital, or similar funds belonging to foreign investors, except that certain payments to non-residents must be reported to the Australian Cash Transaction Reports Agency, which monitors such transactions, and amounts on account of potential Australian tax liabilities may be required to be withheld unless a relevant taxation treaty can be shown to apply.

The Foreign Acquisitions and Takeovers Act 1975

Under Australian law, in certain circumstances foreign persons are prohibited from acquiring more than a limited percentage of the shares in an Australian company without notification to or approval from the Australian Treasurer. These limitations are set forth in the Australian Foreign Acquisitions and Takeovers Act, or the Takeovers Act.

Under the Takeovers Act, as currently in effect, any foreign person, together with associates, is prohibited from acquiring 15% or more of the shares in any company having total assets ofexceeding A$50231 million or more. In addition, a foreign person may not acquire shares in a company having total assets of A$50231 million or more if, as a result of that acquisition, the total holdings of all foreign persons and their associates will exceed 40% in aggregate without the approval of the Australian Treasurer. However, for “U.S. Investors,” a threshold of A$1,004 million applies (except in certain circumstances) to each of the previous acquisitions. A “U.S. Investor” is defined by the Takeovers Act as a U.S. national or a U.S. enterprise.

If the necessary approvals are not obtained, the Treasurer may make an order requiring the acquirer to dispose of the shares it has acquired within a specified period of time. Under the current Australian foreign investment policy, however, it is unlikely that the Treasurer would make such an order where the level of foreign ownership exceeds 40% in the ordinary course of trading, unless the Treasurer finds that the acquisition is contrary to the national interest. The same rule applies if the total holdings of all foreign persons and their associates already exceeds 40% and a foreign person (or its associate) acquires any further shares, including in the course of trading in the secondary market of the ADRs. At present, we do not have total assets of A$50231 million.

If the level of foreign ownership exceeds 40% at any time, we would be considered a foreign person under the Takeovers Act. In such event, we would be required to obtain the approval of the Treasurer for our company, together with our associates, to acquire (i) more than 15% of an Australian company or business with assets totaling over A$~~50,000,000;~~231 million; or (ii) any direct or indirect ownership interest in Australian residential real estate.

The percentage of foreign ownership in our company would also be included in determining the foreign ownership of any Australian company or business in which it may choose to invest. Since we have no current plans for any such acquisitions and do not own any property, any such approvals required to be obtained by us as a foreign person under the Takeovers Act will not affect our current or future ownership or lease of property in Australia.

Our Constitution does not contain any additional limitations on a non-resident’s right to hold or vote our securities.

Australian law requires the transfer of shares in our company to be made in writing. No stamp duty will be payable in Australia on the transfer of ADRs.

E.	~~TAXATION~~Taxation

The following is a discussion of Australian and United States tax consequences material to our shareholders. To the extent that the discussion is based on tax legislation which has not been subject to judicial or administrative interpretation, the views expressed in the discussion might not be accepted by the tax authorities in question or by court. The discussion is not intended, and should not be construed, as legal or professional tax advice and does not exhaust all possible tax considerations.

Holders of our ADSs should consult their own tax advisors as to the United States, Australian or other tax consequences of the purchase, ownership and disposition of ADSs, including, in particular, the effect of any foreign, state or local taxes.

AUSTRALIAN TAX CONSEQUENCES

In this section we discuss the material Australian tax considerations that apply to non-Australian tax residents with respect to the acquisition, ownership and disposal of the absolute beneficial ownership of ADSs, which are evidenced by ADRs. This discussion is based upon existing Australian tax law as of the date of this annual report, which is subject to change, possibly retrospectively. This discussion does not address all aspects of Australian income tax law which may be important to particular investors in light of their individual investment circumstances, such as ADSs or shares held by investors subject to special tax rules (for example, financial institutions, insurance companies or tax exempt organizations). In addition, this summary does not discuss any foreign or state tax considerations, other than ~~stamp~~stam p duty. Prospective investors are urged to consult their tax advisors regarding the Australian and foreign income and other tax considerations of the purchase, ownership and disposition of the ADSs or shares.

Nature of ADSs for Australian Taxation Purposes

Holders of our ADSs are treated as the owners of the underlying ordinary shares for Australian income tax and capital gains tax purposes. Therefore, dividends paid on the underlying ordinary shares will be treated for Australian tax purposes as if they were paid directly to the owners of ADSs, and the disposal of ADSs will be treated for Australian tax purposes as the disposal of the underlying ordinary shares. In the following analysis we discuss the application of the Australian income tax and capital gains tax rules to non-Australian resident holders of ADSs.

Taxation of Dividends

Australia operates a dividend imputation system under which dividends may be declared to be ‘franked’ to the extent of tax paid on company profits. Fully franked dividends are not subject to dividend withholding tax. Dividends that are not franked or are partly franked and are paid to non-Australian resident stockholders are subject to dividend withholding tax, but only to the extent the dividends are not franked.

Dividends paid to a non-resident stockholder are subject to withholding tax at 30%, unless the stockholder is a resident of a country with which Australia has a double taxation agreement. In accordance with the provisions of the Double Taxation Convention between Australia and the United States, the maximum rate of Australian tax on unfranked dividends to which a resident of the United States is beneficially entitled is 15%, where the U.S. resident holds less than 10% of the voting rights in our company, or 5% where the US resident holds 10% or more of the voting rights in our company. The Double Taxation Convention between Australia and the United States does not apply to limit the tax rate on dividends where the ADSs are effectively connected to a permanent establishment or a fixed base carried on by the owner of the ADSs in Australia through which the stockholder carries on business or provides independent personal services, respectively.

Tax on Sales or other Dispositions of Shares –- Capital Gains Tax

Australian capital gains derived by non-Australian residents in respect of the disposal of capital assets that are not taxable Australian property will be disregarded. Non-Australian resident stockholders will not be subject to Australian capital gains tax on the capital gain made on a disposal of our shares, unless they, together with associates, hold 10% or more of our issued capital, tested either at the time of disposal or over any continuous 12 month period in the 24 months prior to disposal, and the value of our shares at the time of disposal are wholly or principally attributable to Australian real property assets.

Australian capital gains tax applies to net capital gains at a taxpayer’s marginal tax rate but for certain stockholders a discount of the capital gain may apply if the shares have been held for 12 months or more. For individuals, this discount is 50%. Net capital gains are calculated after reduction for capital losses, which may only be offset against capital gains.

Tax on Sales or other Dispositions of Shares –- Stockholders Holding Shares on Revenue Account

Some non-Australian resident stockholders may hold shares on revenue rather than on capital account, for example, share traders. These stockholders may have the gains made on the sale or other disposal of the shares included in their assessable income under the ordinary income provisions of the income tax law, if the gains are sourced in Australia.

Non-Australian resident stockholders assessable under these ordinary income provisions in respect of gains made on shares held on revenue account would be assessed for such gains at the Australian tax rates for non-Australian residents, which start at a marginal rate of 29% for non-Australian resident individuals. Some relief from the Australian income tax may be available to such non-Australian resident stockholders under the Double Taxation Convention between the United States and Australia, for example, because the stockholder does not have a permanent establishment in Australia.

To the extent an amount would be included in a non-Australian resident stockholder’s assessable income under both the capital gains tax provisions and the ordinary income provisions, the capital gain amount would generally be reduced, so that the stockholder would not be subject to double tax on any part of the income gain or capital gain.

Dual Residency

If a stockholder were a resident of both Australia and the United States under those countries’ domestic taxation laws, that stockholder may be subject to tax as an Australian resident. If, however, the stockholder is determined to be a U.S. resident for the purposes of the Double Taxation Convention between the United States and Australia, the Australian tax applicable would be limited by the Double Taxation Convention. Stockholders should obtain specialist taxation advice in these circumstances.

Stamp Duty

A transfer of shares of a company listed on the Australian Stock Exchange is not subject to Australian stamp duty except in some circumstances where one person, or associated persons, acquires 90% or more of the shares.

Australian Death Duty

Australia does not have estate or death duties. No capital gains tax liability is realized upon the inheritance of a deceased person’s shares. The disposal of inherited shares by beneficiaries, may, however, give rise to a capital gains tax liability.

Goods and Services Tax

The issue or transfer of shares will not incur Australian goods and services tax and does not require a stockholder to register for Australian goods and services tax purposes.

UNITED STATES FEDERAL INCOME TAX CONSEQUENCES

The following is a summary of certain material U.S. federal income tax consequences that generally apply to U.S. Holders (as defined below) who hold ADRs as capital assets. This summary is based on the United States Internal Revenue Code of 1986, as amended, or the Code, Treasury regulations promulgated thereunder, judicial and administrative interpretations thereof, and the bilateral taxation convention between Australia and the United States, or the Tax Treaty, all as in effect on the date hereof and all of which are subject to change either prospectively or retroactively. This summary does not address all tax considerations that may be relevant with respect to an investment in ADRs. This summary does not discuss all the tax consequences that may be relevant to a U.S. Holder in light of such ~~holder’s~~holder̵ 7;s particular circumstances or to U.S. Holders subject to special rules, including broker-dealers, financial institutions, certain insurance companies, investors liable for alternative minimum tax, tax-exempt organizations, regulated investment companies, non-resident aliens of the United States or taxpayers whose functional currency is not the U.S. dollar, persons who hold the ADRs through partnerships or other pass-through entities, persons who acquired their ADRs through the exercise or cancellation of any employee stock options or otherwise as compensation for their services, investors that actually or constructively own 10% or more of our voting shares, and investors holding ADRs as part of a straddle or appreciated financial position or as part of a hedging or conversion transaction.

If a partnership or an entity treated as a partnership for U.S. federal income tax purposes owns ADRs, the U.S. federal income tax treatment of a partner in such a partnership will generally depend upon the status of the partner and the activities of the partnership. A partnership that owns ADRs and the partners in such partnership should consult their tax advisors about the U.S. federal income tax consequences of holding and disposing of ADRs.

This summary does not address the effect of any U.S. federal taxation other than U.S. federal income taxation. In addition, this summary does not include any discussion of state, local or foreign taxation. You are urged to consult your tax advisors regarding the foreign and U.S. federal, state and local tax considerations of an investment in ADRs.

For purposes of this summary, the term “U.S. Holder” means an individual who is a citizen or, for U.S. federal income tax purposes, a resident of the United States, a corporation or other entity taxable as a corporation created or organized in or under the laws of the United States or any political subdivision thereof, an estate whose income is subject to U.S. federal income tax regardless of its source, or a trust if (a) a court within the United States is able to exercise primary supervision over administration of the trust, and one or more U.S. persons have the authority to control all substantial decisions of the trust or (b) it has a valid election in effect under applicable U.S. Treasury regulations to be treated as a U.S. person.

Taxation of Dividends

For U.S. federal income tax purposes, U.S. Holders of ADRs will be treated as owning the underlying ordinary shares, or ADSs, represented by the ADRs held by them. Subject to the passive foreign investment company rules discussed below, the gross amount of any distributions received with respect to the underlying ordinary shares represented by the ADRs, including the amount of any Australian taxes withheld there from, will constitute dividends for U.S. federal income tax purposes, to the extent of our current and accumulated earnings and profits, as determined under U.S. federal income tax principles. You will be required to include this amount of dividends in gross income as ordinary income. Distributions in excess of our earnings and profits will be treated as a non-taxable return of capital to the ~~extent~~exte nt of your tax basis in the ADRs, and any amount in excess of your tax basis will be treated as gain from the sale of ADRs. See “Disposition of ADRs” below for the discussion on the taxation of capital gains. Dividends will not qualify for the dividends-received deduction generally available to corporations under Section 243 of the Code.

Dividends that we pay in Australian dollars, including the amount of any Australian taxes withheld there from, will be included in your income in a U.S. dollar amount calculated by reference to the exchange rate in effect on the day such dividends are received. A U.S. Holder who receives payment in A$ and converts A$ into U.S. dollars at an exchange rate other than the rate in effect on such day may have a foreign currency exchange gain or loss, which would be treated as ordinary income or loss. U.S. Holders should consult their own tax advisors concerning the U.S. tax consequences of acquiring, holding and disposing of our ADRs.

Subject to complex limitations, any Australian withholding tax imposed on such dividends will be a foreign income tax eligible for credit against a U.S. Holder’s U.S. federal income tax liability (or, alternatively, for deduction against income in determining such tax liability). The limitations set out in the Code include computational rules under which foreign tax credits allowable with respect to specific classes of income cannot exceed the U.S. federal income taxes otherwise payable with respect to each such class of income. Dividends generally will be treated as foreign-source passive category income or general category income for U.S. foreign tax credit purposes. A U.S. Holder will be denied a foreign tax credit with respect to Australian income tax withheld from dividends received with ~~respect~~respec t to the underlying ordinary shares represented by the ADRs to the extent such U.S. Holder has not held the ADRs for at least 16 days of the 31-day period beginning on the date which is 15 days before the ex-dividend date or to the extent such U.S. Holder is under an obligation to make related payments with respect to substantially similar or related property. Any days during which a U.S. Holder has substantially diminished its risk of loss on the ADRs are not counted toward meeting the 16-day holding period required by the statute. The rules relating to the determination of the foreign tax credit are complex, and you should consult with your personal tax advisors to determine whether and to what extent you would be entitled to this credit.

Subject to certain limitations, “qualified dividend income” received by a noncorporate U.S. Holder in tax years beginning on or before December 31, 2010 will be subject to tax at a reduced maximum tax rate of 15 percent. Distributions taxable as dividends generally qualify for the 15 percent rate provided that either: (i) the issuer is entitled to benefits under the Tax Treaty or (ii) the shares are readily tradable on an established securities market in the United States and certain other requirements are met. We believe that we are entitled to benefits under the Tax Treaty and that the ADRs currently are readily tradable on an established securities market in the United States. However, no assurance can be given that the ADRs will remain readily tradable. Furthermore, the ~~reduction~~reductio n does not apply to dividends received from PFICs in any future year, if we are not treated as a PFIC in any future year. U.S. Holders of ADRs should consult their own tax advisors regarding the effect of these rules in their particular circumstances.

Disposition of ADRs

If you sell or otherwise dispose of ADRs, you will recognize gain or loss for U.S. federal income tax purposes in an amount equal to the difference between the amount realized on the sale or other disposition and your adjusted tax basis in the ADRs. Subject to the passive foreign investment company rules discussed below, such gain or loss generally will be capital gain or loss and will be long-term capital gain or loss if you have held the ADRs for more than one year at the time of the sale or other disposition. In general, any gain that you recognize on the sale or other disposition of ADRs will be U.S.-source for purposes of the foreign tax credit limitation; losses will generally be allocated against U.S. source income. Deduction of capital losses is subject to certain limitations under the Code.

In the case of a cash basis U.S. Holder who receives A$ in connection with the sale or disposition of ADRs, the amount realized will be based on the U.S. dollar value of the A$ received with respect to the ADRs as determined on the settlement date of such exchange. A U.S. Holder who receives payment in A$ and converts A$ into U.S. dollars at a conversion rate other than the rate in effect on the settlement date may have a foreign currency exchange gain or loss that would be treated as ordinary income or loss.

An accrual basis U.S. Holder may elect the same treatment required of cash basis taxpayers with respect to a sale or disposition of ADRs, provided that the election is applied consistently from year to year. Such election may not be changed without the consent of the Internal Revenue Service, or the IRS. In the event that an accrual basis U.S. Holder does not elect to be treated as a cash basis taxpayer (pursuant to the Treasury regulations applicable to foreign currency transactions), such U.S. Holder may have a foreign currency gain or loss for U.S. federal income tax purposes because of differences between the U.S. dollar value of the currency received prevailing on the trade date and the settlement date. Any such currency gain or loss would be treated as ordinary income or loss and would be in ~~addition~~additio n to gain or loss, if any, recognized by such U.S. Holder on the sale or disposition of such ADRs.

The Health Care Reform and Education Reconciliation Act of 2010 (Pub. Law 111-152) requires certain U.S. Holders who are individuals to pay a 3.8% tax on the lesser of the excess of their modified adjusted gross income over a threshold amount ($250,000 for married persons filing jointly and $200,000 for single taxpayers) or their “net investment income,” which generally includes capital gains from the disposition of property, for taxable years beginning after December 31, 2012. This tax is in addition to any capital gains taxes due on such investment income. A similar tax will apply to estates and trusts. U.S. Holders should consult their tax advisors regarding the effect, if any, this law may have on them.

Passive Foreign Investment Companies

There is a substantial risk that we are a passive foreign investment company, or PFIC, for U.S. federal income tax purposes. Our treatment as a PFIC could result in a reduction in the after-tax return to the U.S. Holders of our ADRs and may cause a reduction in the value of such securities.

For U.S. federal income tax purposes, we will be classified as a PFIC for any taxable year in which either (i) 75% or more of our gross income is passive income, or (ii) at least 50% of the average value of all of our assets for the taxable year produce or are held for the production of passive income. For this purpose, cash is considered to be an asset which produces passive income. Passive income generally includes dividends, interest, royalties, rents, annuities and the excess of gains over losses from the disposition of assets which produce passive income. As a result of our substantial cash position and the decline in the value of our stock, we believe that we became a PFIC during the taxable year ended June 30, 2005, and once again qualified as a PFIC ~~for~~during each of the ~~taxable~~last five fiscal years, ~~ended June 30, 2006 and 2007 and 2008,~~ under a literal application of the asset test that looks solely to market value. We believe that we will once again qualify as a PFIC for the taxable year ended June 30, ~~2009.~~

2011.

If we are a PFIC, dividends will not qualify for the reduced maximum tax rate, discussed above, and, unless you timely elect to “mark-to-market” your ADRs, as described below:

—·

you will be required to allocate income recognized upon receiving certain dividends or gain recognized upon the disposition of ADRs ratably over your holding period for such ADRs,

—·

the amount allocated to each year during which we are considered a PFIC other than the year of the dividend payment or disposition would be subject to tax at the highest individual or corporate tax rate, as the case may be, in effect for that year and an interest charge would be imposed with respect to the resulting tax liability allocated to each such year,

—·

the amount allocated to the current taxable year and any taxable year before we became a PFIC will be taxable as ordinary income in the current year, and

—·

you will be required to ~~make~~file an annual return on IRS Form ~~8621 regarding distributions received with respect to ADRs and any gain realized on your ADRs.~~8621.

The PFIC provisions discussed above apply to U.S. persons who directly or indirectly hold stock in a PFIC. Both direct and indirect shareholders of PFICs are subject to the rules described above. Generally, a U.S. person is considered an indirect shareholder of a PFIC if it is:

—·

A direct or indirect owner of a pass-through entity, including a trust or estate, that is a direct or indirect shareholder of a PFIC,

—·

A shareholder of a PFIC that is a shareholder of another PFIC, or

—·

A 50%-or-more shareholder of a foreign corporation that is not a PFIC and that directly or indirectly owns stock of a PFIC.

An indirect shareholder may be taxed on a distribution paid to the direct owner of the PFIC and on a disposition of the stock indirectly owned. Indirect shareholders are strongly urged to consult their tax advisors regarding the application of these rules.

If we cease to be a PFIC in a future year, a U.S. Holder may avoid the continued application of the tax treatment described above by electing to be treated as if it sold its ADRs on the last day of the last taxable year in which we were a PFIC. Any gain would be recognized and subject to tax under the rules described above. Loss would not be not recognized. A U.S. Holder’s basis in its ADRs would be increased by the amount of gain, if any, recognized on the sale. A U.S. Holder would be required to treat its holding period for its ADRs as beginning on the day following the last day of the last taxable year in which we were a PFIC.

If the ADRs are considered “marketable stock” and if you elect to “mark-to-market” your ADRs, you would not be subject to the rules described above. Instead, you will generally include in income any excess of the fair market value of the ADRs at the close of each tax year over your adjusted basis in the ADRs. If the fair market value of the ADRs had depreciated below your adjusted basis at the close of the tax year, you may generally deduct the excess of the adjusted basis of the ADRs over its fair market value at that time. However, such deductions generally would be limited to the net mark-to-market gains, if any, that you included in income with respect to such ADRs in prior years. Income recognized and deductions allowed under the mark-to-market provisions, as well as any gain or loss on the disposition of ADRs with respect to which the mark-to-market election is made, is treated as ordinary income or loss (except that loss is treated as capital loss to the extent the loss exceeds the net mark-to-market gains, if any, that a U.S. Holder included in income with respect to such ordinary shares in prior years). However, gain or loss from the disposition of ordinary shares (as to which a “mark-to-market” election was made) in a year in which we are no longer a PFIC, will be capital gain or loss. Our ADRs should be considered “marketable stock” if they traded at least 15 days during each calendar quarter of the relevant calendar year in more than de minimis quantities.

A U.S. Holder of ADRs will not be able to avoid the tax consequences described above by electing to treat us as a qualified electing fund, or QEF, because we do not intend to prepare the information that U.S. Holders would need to make a QEF election.

Backup Withholding and Information Reporting

Payments in respect of ADRs may be subject to information reporting to the U.S. Internal Revenue Service and to U.S. backup withholding tax at a rate equal to the fourth lowest income tax rate applicable to individuals (which, under current law, is 28%). Backup withholding will not apply, however, if you (i) are a corporation or come within certain exempt categories, and demonstrate the fact when so required, or (ii) furnish a correct taxpayer identification number and make any other required certification.

Backup withholding is not an additional tax. Amounts withheld under the backup withholding rules may be credited against a U.S. Holder’s U.S. tax liability, and a U.S. Holder may obtain a refund of any excess amounts withheld under the backup withholding rules by filing the appropriate claim for refund with the IRS.

Any U.S. holder who holds 10% or more in vote or value of our ordinary shares will be subject to certain additional U.S. information reporting requirements.

U.S. Gift and Estate Tax

An individual U.S. Holder of ADRs will be subject to U.S. gift and estate taxes with respect to ADRs in the same manner and to the same extent as with respect to other types of personal property.

F.	~~DIVIDENDS AND PAYING AGENTS~~Dividends and Paying Agents

Not applicable.

G.	~~STATEMENT BY EXPERTS~~Statement by Experts

Not applicable.

H.	~~DOCUMENTS ON DISPLAY~~Documents on Display

We are subject to the reporting requirements of the United States Securities and Exchange Act of 1934, as amended, or the Exchange Act, as applicable to “foreign private issuers” as defined in Rule 3b-4 under the Exchange Act. As a foreign private issuer, we are exempt from certain provisions of the Exchange Act. Accordingly, our proxy solicitations are not subject to the disclosure and procedural requirements of Regulation 14A under the Exchange Act, transactions in our equity securities by our officers and directors are exempt from reporting and the “short-swing” profit recovery provisions contained in Section 16 of the Exchange Act. In addition, we are not required under the Exchange Act to file periodic reports and financial statements as frequently or as promptly as U.S. ~~companies~~compa nies whose securities are registered under the Exchange Act. However, we file with the Securities and Exchange Commission an annual report on Form 20-F containing financial statements that have been examined and reported on, with an opinion expressed by, an independent registered public accounting firm, and we submit reports to the Securities and Exchange Commission on Form 6-K containing (among other things) press releases and unaudited financial information for the first six months of each fiscal year. We post our annual report on Form 20-F on our website (www.pranabio.com) promptly following the filing of our annual report with the Securities and Exchange Commission. The information on our website is not incorporated by reference into this annual report.

This annual report and the exhibits thereto and any other document we file pursuant to the Exchange Act may be inspected without charge and copied at prescribed rates at the Securities and Exchange Commission public reference room at 100 F Street, N.E., Room 1580, Washington, D.C. 20549. You may obtain information on the operation of the Securities and Exchange Commission’s public reference room in Washington, D.C. by calling the Securities and Exchange Commission at 1-800-SEC-0330. The Exchange Act file number for our Securities and Exchange Commission filings is 000-49843.

The Securities and Exchange Commission maintains a website atwww.sec.gov that contains reports, proxy and information statements, and other information regarding registrants that make electronic filings with the Securities and Exchange Commission using its EDGAR (Electronic Data Gathering, Analysis, and Retrieval) system.

The documents concerning our company ~~which are~~ referred to in this annual report may also be inspected at our offices located at Suite 2, 1233 High Street, Armadale, Victoria, Australia, 3143.

I.	~~SUBSIDIARY INFORMATION~~Subsidiary Information

Not applicable.

ITEM 11.

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We invest our excess cash and cash equivalents in interest-bearing accounts and term deposits with banks in Australia. Our management believes that the financial institutions that hold our investments are financially sound and accordingly, minimal credit risk exists with respect to these investments. Certain of our cash equivalents are subject to interest rate risk. Due to the short duration and conservative nature of these instruments, we do not believe that we have a material exposure to interest rate risk. Our major market risk is changes in foreign exchange rates as we had approximately A$~~211,000~~807,000, A$285,000 and A$~~300,000~~369,000 in cash held in U.S. dollars and Euro as of June 30, 2010, 2009 and 2008, respectively. A hypothetical 4%3% adverse movement in end-of-period exchange rates would reduce the cash balance by approximately A$~~8,450~~23,500, A$8,310 and A$~~12,070,~~10,158, respectively.

We do not currently utilize derivative financial instruments or other financial instruments subject to market risk.

We conduct our activities almost exclusively in Australia. However, we are required to make certain payments in U.S. dollars and other currencies. An adverse movement in end-of-period exchange rates would not have a material impact on our operating results. In 2008 and ~~2007,~~2010, the Australian dollar ~~depreciated~~appreciated against the U.S. dollar by 11% and ~~12%,~~5% respectively, while the Australian dollar ~~appreciated~~depreciated against the U.S. dollar by 16% in 2009. As of June 30, ~~2009,~~2010, payables in U.S. dollars and other currencies were immaterial. A hypothetical 4%3% adverse movement in the U.S. dollar and ~~11%~~Euro and 12% adverse movement in the Great British Pound exchange rates would increase the cost of these payables by approximately A$~~2,000.~~

4,000.

ITEM 12.

DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES

~~Not applicable.~~

PART II

Fees and Charges Payable by ADR Holders

The table below summarizes the fees and charges that a holder of our ADRs may have to pay, directly or indirectly, to our ADR depositary, The Bank of New York Mellon, or BoNY, pursuant to the Deposit Agreement, which was filed as Exhibit 2.1 to our Registration Statement on Form F-6 filed with the SEC on December 21, 2007, and the types of services and the amount of the fees or charges paid for such services. The disclosure under this heading “Fees and Charges Payable by ADR Holders” is subject to and qualified in its entirety by reference to the full text of the Deposit Agreement. The holder of an ADR may have to pay the following fees and charges to BoNY in connection with ownership of the ADR:

Category	Depositary actions		Associated fee or charge
(a) Depositing or substituting the underlying shares	Issuances against deposits of shares, including deposits and issuances pursuant to a stock dividend or stock split declared by us or issuances pursuant to a merger, exchange of securities or any other transaction or event affecting the ADSs or the deposited securities		Up to US $5.00 for each 100 ADSs (or portion thereof) issued or delivered (as the case may be) The depositary may sell (by public or private sale) sufficient securities and property received in respect of share distributions, rights and other distributions prior to such deposit to pay such charge
(b) Receiving or distributing dividends	Cash distributions made pursuant to the deposit agreement		US $0.02 or less per ADS
(c) Selling or exercising rights	Distribution or sale of securities, the fee being in an amount equal to the fee for the execution and delivery of ADSs which would have been charged as a result of the deposit of such securities		Up to US $5.00 for each 100 ADSs (or portion thereof)
(d) Withdrawing, cancelling or reducing an underlying security	Acceptance of ADSs surrendered for withdrawal, cancellation or reduction of deposited securities		Up to US $5.00 for each 100 ADSs (or portion thereof) surrendered, cancelled or reduced (as the case may be) The depositary may sell (by public or private sale) sufficient securities and property received in respect of share distributions, rights and other distributions prior to such deposit to pay such charge
(e) Transferring, combination or split-up of receipts	Transfer, combination and split-up of ADRs		US $1.50 per ADR
(f) Fees and expenses of the depositary	Fees and expenses incurred by the depositary or the depositary’s agents on behalf of holders, including in connection with:		Expenses payable at the sole discretion of the depositary by billing ADR holders or by deducting such charges from one or more cash dividends or other cash distributions
	●	compliance with foreign exchange control regulations or any law or regulation relating to foreign investment
	●	stock transfer or other taxes and governmental charges
	●	cable, telex and facsimile transmission and delivery charges
	●	fees for the transfer or registration of deposited securities in connection with the deposit or withdrawal of deposited securities
	●	expenses of the depositary in connection with the conversion of foreign currency into U.S. dollars
	●	any other charge payable by the depositary or the depositary’s agents in connection with the servicing of the shares or other deposited securities (which charge shall be assessed against holders as of the record date or dates set by the depositary)

Fees and Payments Made by the Depositary to the Company

BoNY, as ADR depositary, has agreed to reimburse certain expenses related to our ADR program and incurred by us in connection with the program. For the year ended June 30, 2010, the ADR depositary reimbursed us, or paid on our behalf to third parties, a total of US $562. The ADR depositary also waived US $30,000 of its fees for standard costs associated with the administration of the ADR program.

Fees and Payments Made by the Company to the Depositary

We incurred expenses in relation to services for our annual general meeting and special general meeting of shareholders. For the year ended June 30, 2010, we paid BoNY a total of US$9,279 (comprised of payments for the distribution and printing of meeting material and proxy vote tabulation).

ITEM 13.

DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES

Not applicable.

ITEM 14.

MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS

Not applicable.

ITEM 15.

CONTROLS AND PROCEDURES

Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our Exchange Act reports is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to our chief executive officer and chief financial officer to allow timely decisions regarding required disclosure. Our management, including our chief executive officer and chief financial officer, conducted an evaluation of our disclosure controls and procedures, as defined under Exchange Act Rule 13a-15(e), as of the end of the period covered by this Annual Report on Form 20-F. Based upon that evaluation, our chief executive officer and chief financial officer have ~~concluded~~co ncluded that, as of June 30, ~~2009,~~2010, our disclosure controls and procedures were effective.

Management’s

Management's Annual Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over our financial reporting. Internal control over financial reporting is defined in Rule 13a-15(f) or 15d-15(f) promulgated under the Securities Exchange Act of 1934 as a process designed by, or under the supervision of, the company’s principal executive and principal financial officers and effected by the company’s board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles and includes those policies and procedures that:

—·

pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the company;

—·

provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and

—·

provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use of disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Our management assessed the effectiveness of our internal control over financial reporting as of June 30, ~~2009.~~2010. In making this assessment, our management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated Framework. Based on that assessment, our management concluded that as of June 30, ~~2009,~~2010, our internal control over financial reporting is effective.

This annual report does not include an attestation report of our independent registered public accounting firm regarding internal control over financial reporting. Management’s report was not subject to attestation by our independent registered public accounting firm pursuant to temporary rules of the Securities and Exchange Commission that permit us to provide only management’s report in this annual report.

Changes in Internal Control over Financial Reporting

During the year ended June 30, ~~2009,~~2010, there were no changes in our internal control over financial reporting that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

ITEM 16.

RESERVED

~~ITEM 16A.~~

~~AUDIT COMMITTEE FINANCIAL EXPERT~~

ITEM 16A. AUDIT COMMITTEE FINANCIAL EXPERT

Our Board of Directors has determined that Mr. Brian Meltzer, an independent director, meets the definition of an audit committee financial expert, as defined by rules of the Securities and Exchange Commission. For a brief listing of Mr. Meltzer’s relevant experience, see Item 6.A. “Directors, Senior Management and Employees –-- Directors and Senior Management.”

~~ITEM 16B.~~

~~CODE OF ETHICS~~

ITEM 16B. CODE OF ETHICS

We have adopted a code of ethics that applies to our chief executive officer and all senior financial officers of our company, including the chief financial officer, chief accounting officer or controller, or persons performing similar functions. The code of ethics is publicly available on our website at~~www.pranabio.com~~. www.pranabio.com. Written copies are available upon request. If we make any substantive amendment to the code of ethics or grant any waivers, including any implicit waiver, from a provision of the codes of ethics, we will disclose the nature of such amendment or waiver on our website.

~~ITEM 16C.~~

~~PRINCIPAL ACCOUNTANT FEES AND SERVICES~~

ITEM 16C. PRINCIPAL ACCOUNTANT FEES AND SERVICES

Fees Paid to Independent Public Accountants

The following table sets forth, for each of the years indicated, the fees billed by PricewaterhouseCoopers, which has served as our principal independent registered public accounting firm since November 30, 2006.

Year Ended June 30,
Services Rendered
2009
2008

Audit A$ 120,951 A$ 219,920
Audit-Related - -
Tax - -
Other - -
Total A$ 120,951 A$ 219,920

	Year Ended June 30,
Services Rendered	2010		2009
Audit (1)	A$	140,672	A$	120,951
Audit-Related (2)		45,000		--
Other (3)		26,637		--
Total	A$	212,309	A$	120,951

______________

(1) Audit fees consist of services that would normally be provided in connection with statutory and regulatory filings or engagements, including services that generally only the independent accountant can reasonably provide.

(2) Audit-related fees relate to services provided in connection with the auditor’s review of our internal controls.

(3) Other fees relate to services provided in connection with a review performed by the Securities and Exchange Commission.

Deloitte Touche Tohmatsu served as our principal independent registered public accounting firm until November 30, 2006. The fees billed by Deloitte Touche Tohmatsu, as well as the other member firms of Deloitte Touche Tohmatsu and their respective affiliates, for the 2009 ~~and 2008~~ fiscal ~~years were~~year was A$9,267 ~~and A$71,773, respectively,~~ for audit-related services provided in connection with a Securities and Exchange Commission review of our annual report on Form 20-F for the fiscal year ended June 30, 2006 and an amendment to our annual report on Form 20-F for such period.

No fees were billed by Deloitte Touche Tohmatsu in fiscal 2010.

Pre-Approval Policies and Procedures

Our Audit Committee has adopted policies and procedures for the pre-approval of audit and non-audit services rendered by our independent registered public accounting firm. Pre-approval of an audit or non-audit service may be given as a general pre-approval, as part of the audit committee’s approval of the scope of the engagement of our independent registered public accounting firm, or on an individual basis. Any proposed services exceeding general pre-approved levels also requires specific pre-approval by our audit committee. The policy prohibits retention of the independent registered public accounting firm to perform the prohibited non-audit functions defined in Section 201 of the Sarbanes-Oxley Act or the rules of the Securities and Exchange Commission, and also requires the audit committee to ~~consider~~co nsider whether proposed services are compatible with the independence of the registered public accounting firm. All of the fees described above were pre-approved by our Audit Committee.

~~ITEM 16D.~~

~~EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES~~

ITEM 16D. EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES

Not applicable.

~~ITEM 16E.~~

~~PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS~~

ITEM 16E. PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS

Issuer Purchase of Equity Securities

Neither we, nor any affiliated purchaser of our company, has purchased any of our securities during the year ended June 30, ~~2009.~~

2010.

~~ITEM 16F.~~

~~CHANGES IN REGISTRANT’S CERTIFYING ACCOUNTANT~~

~~Not applicable.~~

ITEM 16F. CHANGES IN REGISTRANT’S CERTIFYING ACCOUNTANT

None.

~~ITEM 16G.~~

~~CORPORATE GOVERNANCE~~

ITEM 16G. CORPORATE GOVERNANCE

Under NASDAQ ~~Marketplace Rule 4350, or Rule 4350,~~Listing Rule5615(a)(3), foreign private issuers, such as our company, are permitted to follow certain home country corporate governance practices instead of certain provisions of ~~Rule 4350.~~the NASDAQ Listing Rules. A foreign private issuer that elects to follow a home country practice instead of any of such ~~provisions of Rule 4350,~~NASDAQ rules must submit to NASDAQ, in advance, a written statement from an independent counsel in such issuer’s home country certifying that the issuer’s practices are not prohibited by the home country’s laws.

On March 30, 2005, we provided NASDAQ with a notice of non-compliance with ~~Rule 4350~~NASDAQ Listing Rules with respect to the requirement to maintain a majority of independent directors, as defined under NASDAQ ~~Marketplace~~Listing Rules, and the requirement that audit committee members meet the independence standard of the NASDAQ ~~Marketplace~~Listing Rules. Instead, under Australian law and practice, we are not required to appoint a certain number of independent directors to our Board of Directors or audit committee. However, as of July 2005, we have a majority of independent directors, within the meaning of NASDAQ ~~Marketplace~~Listing Rules, on our Board of Directors and our audit committee members meet the independence requirements of NASDAQ and the Securities and Exchange Commission.

ITEM 17.

FINANCIAL STATEMENTS

Our company has elected to furnish financial statements and related information specified in Item 18.

ITEM 18.

FINANCIAL STATEMENTS


		Page



Index to Consolidated Financial Statements	F-0
Report of Independent Registered Public Accounting Firm for fiscal years 2010 and 2009	F-1
Consolidated ~~Balance Sheet~~Statements of Financial Position	F-2
Consolidated Statements of Comprehensive Income ~~Statements~~	F-3
Consolidated Cash Flow Statements	F-4
Consolidated Statements of Changes in ~~Stockholders'~~Stockholders’ Equity	F-5
Notes to Consolidated Financial Statements	F-6

ITEM 19.

EXHIBITS

Index to Exhibits

Exhibit

Description

1.1

Constitution of Registrant (1)

2.1

Deposit Agreement dated March 23, 2001, as amended and restated as of December 21, 2007, among the Registrant, the Bank of New York, as Depositary, and owners and holders from time to time of ADRs issued thereunder, including the Form of American Depositary Receipts ~~(1)~~(2)

4.1

Agreement for the Assignment of Patents and Intellectual Property Licensing dated February 8, 2000, between Registrant and the Biomolecular Research Institute ~~(2)~~(3)

4.2

License Agreement dated January 1, 2001, between the Registrant and The General Hospital Corporation ~~(2)~~(3)

4.3

Variation Agreement dated August 8, 2001, between the Registrant and The General Hospital Corporation, which amends the License Agreement dated January 1, 2001, between the parties ~~(2)~~(3)

4.4

Agreement to Provide Accounting, Administration, Corporate Advice and Company Secretarial Services dated February 23, 2000, between the Registrant and Malvern Administrative Services (now named The CFO solution) ~~(2)~~(3)

4.5

Second Amendment to Exclusive License Agreement dated January 1, 2001, between the Registrant and The General Hospital Corporation, dated March 15, 2004, between the between the Registrant and The General Hospital Corporation ~~(3)~~(4)

4.6

Third Research Funding and Intellectual Property Assignment Agreement dated December 2, 2006 ~~(4)~~(5)

4.7

~~General Services Agreement dated November 13, 2006, between the Registrant and Quintiles Limited (5)~~

~~4.8~~

GMP 30kg Manufacture Agreement dated June 6, 2007, between the Registrant and Institute of Drug Technology Australia Limited (6)

~~4.9~~4.8

GMP 4kg Manufacture Agreement dated June 6, 2007, between the Registrant and Institute of Drug Technology Australia Limited (7)

~~4.10~~4.9

Settlement Agreement dated July 28, 2004, among the Registrant, P.N. Gerolymatos S.A, or PNG, Mr. Gerolymatos, The General Hospital Corporation of Massachusetts, or The GHC, Professor Ashley Bush, Dr. Rudolph Tanzi and Dr. Robert Cherny and the ancillary agreements of even date therewith exhibited thereto, including the Patent Assignment and Settlement Agreement among the Registrant and PNG, Patent Rights Security Agreement among the Registrant and PNG and the Derivatives Agreement among the Registrant and PNG (8)

~~4.11~~4.10

Prana Biotechnology Limited, 2004 American Depository Share (ADS) Option Plan (9)

~~4.12~~4.11

Prana Biotechnology Limited, 2004 Employees’, ~~Directors'~~Directors’ and Consultants’ Share and Option Plan (10)

~~4.13~~4.12

Employment Agreement dated September 21, 2007, among the Registrant and Mr. Kempler (11)

~~4.14~~4.13

Letter Agreements effective as of June 12, 2007 between the Registrant and Ms. Dianne Angus (12)

~~4.15~~4.14

Assignment and Novation Deed between Commonwealth Scientific Industrial and Research Organization and the Biomolecular Research Institute and the Registrant dated September 10, 2007 (13)

~~4.16~~4.15

Agreement dated May 22, 2007 by and between the Registrant and Patheon Inc. regarding the formulation, development and manufacture of capsules of PBT2 (14)

~~4.17~~4.16

Placement Confirmation Letter dated September 8, 2009, between the Registrant and BAM Capital LLC (15)

~~4.18~~4.17

Consultancy Services Agreement dated January 8, 2004, between the Registrant and Professor Ashley Bush (16)

~~4.19~~4.18

Letter agreement dated November 14, 2007, between the Registrant and Professor Ashley Bush (17)

~~4.20~~4.19

Letter agreement dated May 22, 2009, between the Registrant and Professor Ashley Bush (18)

~~4.21~~4.20		Process Development and Manufacturing Agreement dated December 26, 2008, between the Registrant and Dr. Reddy’s Laboratories Limited, as amended by Amendment No. 1 effective February 3, 2009 and Amendment No. 2 effective March 13, 2009 (19)
4.21		Amendments to Process Development and Manufacturing Agreement dated December 26, 2008 between the Registrant and Dr. Reddy’s Laboratories Limited, as amended: Amendment ~~No.~~No 3 effective July 6, ~~2009 by~~2009; Amendment No. 4 effective September 15, 2009; Amendment No. 5 effective November 13, 2009; Amendment No. 6 effective December 22, 2009; Amendment No. 7 effective December 22, 2009; Amendment No. 8 effective May 7, 2010; and Amendment No. 9 effective May 20, 2010
4.22		Agreement dated June 23, 2010, between the ~~parties~~Registrant and Quintiles Limited

8.1

List of Subsidiaries of the Registrant

12.1

Certification of Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act, as amended

12.2

Certification of Chief Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act, as amended

13.1

Certification of Chief Executive Officer pursuant to 18 U.S.C. Section1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

13.2

Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

15.1

Consent of PricewaterhouseCoopers, Registered Public Accounting Firm

_______________

(1)	Filed as Exhibit 1.1 to our Annual Report on Form 20-F for the year ended June 30, 2009, and incorporated herein by reference.

(2)	Incorporated by reference to the Post-Effective Amendment No. 1 to Form F-6 Registration Statement filed with the Securities and Exchange Commission on December 12, 2007 (File 333-136944).

~~(2)~~(3)

Incorporated by reference to our Registration Statement on Form 20-F filed with the Securities and Exchange Commission on May 28, 2002 (File No. 000-49843).

~~(3)~~(4)

Filed as Exhibit 4.6 to our Annual Report on Form 20-F for the year ended June 30, 2004, and incorporated herein by reference.

~~(4)~~(5)

Filed as Exhibit 4.7 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference

~~(5)~~

~~Filed as Exhibit 4.8 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.~~

(6)	Filed as Exhibit 4.9 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(7)	Filed as Exhibit 4.10 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(8)	Filed as Exhibit 4.21 to our Annual Report on Form 20-F for the year ended June 30, 2004, and incorporated herein by reference.

(9)	Incorporated by reference to Annexure A to Item 1 of our Report on Form 6-K for the month of November 2004.

(10)	Incorporated by reference to Annexure B to Item 1 of our Report on Form 6-K for the month of November 2004.

(11)	Filed as Exhibit 4.19 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(12)	Filed as Exhibit 4.21 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(13)	Filed as Exhibit 4.22 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(14)	Filed as Exhibit 4.25 to our Annual Report on Form 20-F for the year ended June 30, 2007, and incorporated herein by reference.

(15)	Incorporated by reference to our Report on Form 6-K for the month of September 2009.

(16)	Incorporated by reference to Item 1 of our Report on Form 6-K for the month of June 2009.

(17)	Incorporated by reference to Item 2 of our Report on Form 6-K for the month of June 2009.

(18)	Filed as Exhibit 4.20 to our Annual Report on Form 20-F for the year ended June 30, 2009, and incorporated herein by reference.

(19)	Filed as Exhibit 4.21 to our Annual Report on Form 20-F for the year ended June 30, 2009, and incorporated herein by reference.

PRANA BIOTECHNOLOGY LIMITED

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS


		Page Number




Report of Independent Registered Public Accounting Firm for fiscal years ~~2009~~2010 and ~~2008~~2009	F-1

Consolidated ~~Balance Sheet~~Statements of Financial Position	F-2

Consolidated Statements of Comprehensive Income ~~Statements~~	F-3

Consolidated Cash Flow Statements	F-4

Consolidated Statements of Changes in ~~Stockholders'~~Stockholders’ Equity	F-5

Notes to Consolidated Financial Statements	F-6

F - 0

PRICEWATERHOUSECOOPERS

Report of Independent Registered Public Accounting Firm

To The Board of Directors and Shareholders of Prana Biotechnology Limited

In our opinion, the accompanying consolidated ~~balance sheets~~statements of financial position and the related consolidated statements of comprehensive income, ~~shareholders’~~consolidated statements of changes in stockholders' equity, and consolidated cash ~~flows~~flow statements present fairly, in all material respects, the financial position of Prana Biotechnology Limited and its subsidiaries at 30 June ~~2009~~2010 and 30 June ~~2008,~~2009, and the results of their operations and their cash flows for each of the three years in the period ended 30 June ~~2009~~2010 in conformity with International Financial Reporting Standards as issued by the International Accounting Standards Board. These financial statements are the responsibility of the ~~Company’s~~Company's management. Our responsibility is to express an opinion on ~~these~~th ese financial statements based on our audits. We conducted our audits of these statements in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

Our audit of the consolidated financial statements of Prana Biotechnology Limited and its subsidiaries was conducted for the purpose of forming an opinion on the consolidated financial statements taken as a whole. The Company has included parent entity only information in the notes to the financial statements. Such parent entity only information is presented for purposes of additional analysis and is not a requirement of the consolidated financial statements presented in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board. Such information has been subjected to the auditing procedures applied in the audit of the consolidated financial statements, and, in our opinion, is fairly stated in all material respects in relation to the consolidated financial statements taken as a whole.

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company has suffered recurring losses from operations that raise substantial doubt about its ability to continue as a going concern. Management's plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

/s/PricewaterhouseCoopers

PricewaterhouseCoopers

Melbourne, Australia
~~23 September 2009~~

9 November 2010

F - 1

PRANA BIOTECHNOLOGY LIMITED

CONSOLIDATED ~~BALANCE SHEET~~
STATEMENTS OF FINANCIAL POSITION

(in Australian dollars, except number of shares)

June 30,
Notes
2009
2008

Current Assets
Cash and cash equivalents 4,304,977 11,219,035
Trade and other receivables 5 526 120,641
Other current assets 6 185,433 254,325

Total Current Assets 4,490,936 11,594,001

Non Current Assets
Property and equipment, net of accumulated
depreciation of A$525,767 and A$576,826 respectively 7 71,150 69,148
Other non current assets 6 35,164 35,164

Total Non Current Assets 106,314 104,312

Total Assets 4,597,250 �� 11,698,313

Current Liabilities
Trade and other payables 8 604,142 849,113
Provisions 9 194,903 121,082
Financial liabilities 10 - 772,430

Total Current Liabilities 799,045 1,742,625

Non-Current Liabilities
Provisions 9 48,389 89,361

Total Non-Current Liabilities 48,389 89,361

Total Liabilities 847,434 1,831,986

Commitments and contingencies 11 - -

Net Assets 3,749,816 9,866,327

Equity
Issued and unissued capital
2009: 202,710,473 fully paid ordinary shares
14,279,133 options over fully paid ordinary shares
2008: 201,800,240 fully paid ordinary shares
14,279,133 options over fully paid
ordinary shares 12 70,188,989 69,842,303
Reserves 13 7,127,332 6,067,740
Accumulated deficit during the development stage 14 (73,566,505 ) (66,043,716 )

Total Equity 3,749,816 9,866,327

			June 30,
	Notes		2010			2009
Assets
Current Assets
Cash and cash equivalents				5,227,298			4,304,977
Trade and other receivables		5		825			526
Other current assets		6		1,479,603			185,433

Total Current Assets				6,707,726			4,490,936

Non Current Assets
Property and equipment, net of accumulated depreciation of A$329,646 and A$525,767 respectively		7		58,527			71,150
Other non-current assets		6		35,164			35,164

Total Non-Current Assets				93,691			106,314

Total Assets				6,801,417			4,597,250

Liabilities
Current Liabilities
Trade and other payables		8		1,244,417			604,142
Provisions		9		256,074			194,903

Total Current Liabilities				1,500,491			799,045

Non-Current Liabilities
Provisions		9		71,610			48,389

Total Non-Current Liabilities				71,610			48,389

Total Liabilities				1,572,101			847,434

Net Assets				5,229,316			3,749,816

Equity
Issued and unissued capital 2010: 234,045,871 fully paid ordinary shares Nil options over fully paid ordinary shares 2009: 202,710,473 fully paid ordinary shares 14,279,133 options over fully paid ordinary shares		12		75,120,164			70,188,989
Reserves		13		8,582,579			7,127,332
Accumulated deficit during the development stage		14		(78,473,427	)		(73,566,505	)

Total Equity				5,229,316			3,749,816

The accompanying notes are an integral part of the consolidated financial statements.

F - 2

PRANA BIOTECHNOLOGY LIMITED

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME ~~STATEMENTS~~

(in Australian dollars, except number of shares)

Years ended June 30,
Notes
2009
2008
2007

Revenues from continuing operations 2 428,193 490,943 507,150
Other income 2 - 170 287

Research and development expenses 3 (2,215,358 ) (5,757,168 ) (4,492,193 )
Personnel expenses 3 (3,832,804 ) (5,350,189 ) (4,554,731 )
Intellectual property expenses 3 (1,107,534 ) (469,428 ) (600,232 )
Auditor and accounting expenses 3 (129,998 ) (331,950 ) (260,117 )
Travel expenses 3 (195,251 ) (146,651 ) (309,997 )
Public relations and marketing expenses 3 (222,679 ) (141,337 ) (215,455 )
Depreciation expenses 3 (34,190 ) (25,349 ) (58,582 )
Other expenses 3 (978,875 ) (975,404 ) (1,008,563 )
Foreign exchange gain (loss) 3 (6,723 ) (402,886 ) (757,578 )
Gain (loss) on fair value of financial liabilities 3 772,430 (451,429 ) 607,691

Loss before income tax expense (7,522,789 ) (13,560,678 ) (11,142,320 )

Income tax expense 4 - - -

Net loss 14 (7,522,789 ) (13,560,678 ) (11,142,320 )

Loss per share (basic and diluted) 19 (0.04 ) (0.08 ) (0.08 )

Weighted average number of ordinary shares used in computing basic
and diluted net loss per share 202,357,885 174,714,146 140,754,495

			Years ended June 30,
	Notes		2010			2009			2008

Revenues from ordinary activities		2		215,008			428,193			490,943
Other income		2		-			-			170

Research and development expenses, net		3		(87,992	)		(2,215,358	)		(5,757,168	)
Personnel expenses		3		(3,087,234	)		(3,832,804	)		(5,350,189	)
Intellectual property expenses		3		(431,082	)		(1,107,534	)		(469,428	)
Auditor and accounting expenses		3		(168,909	)		(129,998	)		(331,950	)
Travel expenses		3		(234,555	)		(195,251	)		(146,651	)
Public relations and marketing expenses		3		(130,090	)		(222,679	)		(141,337	)
Depreciation expenses		3		(35,290	)		(34,190	)		(25,349	)
Other expenses		3		(940,699	)		(978,875	)		(975,404	)
Foreign exchange gain (loss)		3		(6,079	)		(6,723	)		(402,886	)
Gain (loss) on fair value of financial liabilities		3		-			772,430			(451,429	)

Loss before income tax expense				(4,906,922	)		(7,522,789	)		(13,560,678	)

Income tax expense		4		-			-			-

Loss for the year				(4,906,922	)		(7,522,789	)		(13,560,678	)

Other comprehensive income				-			-			-

Total comprehensive income for the year		14		(4,906,922	)		(7,522,789	)		(13,560,678	)

Loss per share (basic and diluted)		19		(0.02	)		(0.04	)		(0.08	)

Weighted average number of ordinary shares used in computing basic and diluted net loss per share				227,527,388			202,357,885			174,714,146

The accompanying notes are an integral part of the consolidated financial statements.

F - 3

PRANA BIOTECHNOLOGY LIMITED

CONSOLIDATED CASH FLOW STATEMENTS

(in Australian dollars)

Years Ended June 30
Notes
2009
2008
2007

Cash Flows from Operating Activities
Payments to suppliers and employees (7,511,372 ) (9,766,851 ) (9,726,197 )
Interest received 517,198 375,461 526,447

Net cash flows used in operating activities 15(a) (6,994,174 ) (9,391,390 ) (9,199,750 )

Cash Flows from Investing Activities
Proceeds from sale of equipment - - 300
Payment for rental deposits - (35,164 ) -
Payments for purchase of equipment (36,192 ) (46,606 ) (4,559 )

Net cash flows used in investing activities (36,192 ) (81,770 ) (4,259 )

Cash Flows from Financing Activities
Proceeds from exercise of options and issue
of securities 114,000 14,297,620 7,783,486
Payment of share issue costs (13,193 ) (580,372 ) (408,761 )

Net cash flows provided by (used in)
financing activities 100,807 13,717,248 7,374,725

Net increase (decrease) in cash and cash
equivalents (6,929,559 ) 4,244,088 (1,829,284 )

Opening cash and cash equivalents brought
forward 11,219,035 7,409,256 10,013,778
Exchange rate adjustments on cash and cash
equivalents held in foreign currencies 15,501 (434,309 ) (775,238 )

Closing cash and cash equivalents carried
forward 15(b) 4,304,977 11,219,035 7,409,256

			Years Ended June 30
	Notes		2010			2009			2008

Cash Flows from Operating Activities
Payments to suppliers and employees				(4,923,648	)		(7,511,372	)		(9,766,851	)
Interest received				214,709			517,198			375,461

Net cash flows used in operating activities		15(a)		(4,708,939	)		(6,994,174	)		(9,391,390	)

Cash Flows from Investing Activities
Payment for rental deposits				-			-			(35,164	)
Payments for purchase of equipment				(22,667	)		(36,192	)		(46,606	)

Net cash flows used in investing activities				(22,667	)		(36,192	)		(81,770	)

Cash Flows from Financing Activities
Proceeds from exercise of options and issue of securities				6,000,000			114,000			14,297,620
Payment of share issue costs				(344,056	)		(13,193	)		(580,372	)

Net cash flows provided by financing activities				5,655,944			100,807			13,717,248

Net increase (decrease) in cash and cash equivalents				924,338			(6,929,559	)		4,244,088

Opening cash and cash equivalents brought forward				4,304,977			11,219,035			7,409,256
Exchange rate adjustments on cash and cash equivalents held in foreign currencies				(2,017	)		15,501			(434,309	)

Closing cash and cash equivalents carried forward		15(b)		5,227,298			4,304,977			11,219,035

The accompanying notes are an integral part of the consolidated financial statements.

F - 4

PRANA BIOTECHNOLOGY LIMITED

CONSOLIDATED STATEMENTS OF CHANGES IN ~~STOCKHOLDERS'~~STOCKHOLDERS’ EQUITY

(in Australian dollars, except for number of shares)

Notes
Number of
Shares
Issued and
unissued
Capital
Reserves
Accumulated
Deficit
During
Development
Stage
Total Equity
Balance, June 30, 2006 128,144,260 46,274,127 2,867,249 (41,340,718 ) 7,800,658

Net loss 14 - - - (11,142,320 ) (11,142,320 )
Issuance of shares in connection with
private placement, net of costs 12(b) 22,014,468 6,108,868 - - 6,108,868
Issuance of options in connection with
private placement 12(c) - 1,262,339 - - 1,262,339
Non-cash issuance of shares to consultants 12(b) 481,250 194,579 - - 194,579
Non-cash issuance of shares to employees 12(b) 120,000 45,600 - - 45,600
Non-cash issuance of options to
consultants 13(b) - - 163,701 - 163,701
Non-cash issuance of options to directors
and employees 13(b) - - 989,721 - 989,721
Issuance of shares in connection with 12(b)&
exercise of options, net of costs 13(b) 758,000 102,899 (106,739 ) - (3,840 )
Amortization of option expenses 13(b) - - 195,839 - 195,839
Options forfeited 13(b) - - (2,950 ) - (2,950 )
Balance, June 30, 2007 151,517,978 53,988,412 4,106,821 (52,483,038 ) 5,612,195

Net loss 14 - - - (13,560,678 ) (13,560,678 )
Issuance of shares in connection with
private placement, net of costs 12(b) 47,903,699 13,717,248 - - 13,717,248
Issuance of options in connection with
private placement 12(c) - 1,439,305 - - 1,439,305
Non-cash issuance of shares to consultants 12(b) 985,000 288,402 - - 288,402
Non-cash issuance of options to
consultants 13(b) - - 482,150 - 482,150
Non-cash issuance of options to directors
and employees 13(b) - - 1,467,359 - 1,467,359
Issuance of shares in connection with 12(b)&
exercise of options, net of costs 13(b) 1,393,563 408,936 (408,936 ) - -
Amortization of option expenses 13(b) - - 563,479 - 563,479
Options forfeited 13(b) - - (143,133 ) - (143,133 )
Balance, June 30, 2008 201,800,240 69,842,303 6,067,740 (66,043,716 ) 9,866,327
Net loss 14 - - - (7,522,789 ) (7,522,789 )
Issuance of shares in connection with
private placement, net of costs 12(b) - - - - -
Issuance of options in connection with
private placement 12(c) - - - - -
Non-cash issuance of shares to consultants 12(b) 93,750 128,932 - - 128,932
Non-cash issuance of options to
consultants 13(b) - - 622,700 - 622,700
Non-cash issuance of options to directors
and employees 13(b) - - 138,213 - 138,213
Issuance of shares in connection with 12(b)&
exercise of options, net of costs 13(b) 816,483 217,754 (217,754 ) - -
Amortization of option expenses 13(b) - - 516,433 - 516,433
Option forfeited 13(b) - - - - -
Balance, June 30, 2009 202,710,473 70,188,989 7,127,332 (73,566,505 ) 3,749,816

	Notes		Number of Shares		Issued and unissued Capital		Reserves			Accumulated Deficit During Development Stage			Total Equity
Balance, June 30, 2007				151,517,978		53,988,412		4,106,821			(52,483,038	)		5,612,195
Transactions with owners in their capacity as owners:
Issuance of shares in connection with private placement, net of costs		12(b)		47,903,699		13,717,248		-			-			13,717,248
Issuance of options in connection with private placement		12(c)		-		1,439,305		-			-			1,439,305
Non-cash issuance of shares to consultants		12(b)		985,000		288,402		-			-			288,402
Non-cash issuance of options to consultants		13(b)		-		-		482,150			-			482,150
Non-cash issuance of options to directors and employees		13(b)		-		-		1,467,359			-			1,467,359
Issuance of shares in connection with exercise of options, net of costs	12(b) & 13(b)			1,393,563		408,936		(408,936	)		-			-
Share options – value of share option scheme		13(b)		-		-		563,479			-			563,479
Options forfeited		13(b)		-		-		(143,133	)		-			(143,133	)
				201,800,240		69,842,303		6,067,740			(52,483,038	)		23,427,005
Net loss		14		-		-		-			(13,560,678	)		(13,560,678	)
Total comprehensive income for the year				-		-		-			(13,560,678	)		(13,560,678	)
Balance, June 30, 2008				201,800,240		69,842,303		6,067,740			(66,043,716	)		9,866,327
Transactions with owners in their capacity as owners:
Non-cash issuance of shares to consultants		12(b)		93,750		128,932		-			-			128,932
Non-cash issuance of options to consultants		13(b)		-		-		622,700			-			622,700
Non-cash issuance of options to directors and employees		13(b)		-		-		138,213			-			138,213
Issuance of shares in connection with exercise of options, net of costs	12(b) & 13(b)			816,483		217,754		(217,754	)		-			-
Share options – value of share option scheme		13(b)		-		-		516,433			-			516,433
				202,710,473		70,188,989		7,127,332			(66,043,716	)		11,272,605
Net loss		14		-		-		-			(7,522,789	)		(7,522,789	)
Total comprehensive income for the year				-		-		-			(7,522,789	)		(7,522,789	)

Balance, June 30, 2009			202,710,473	70,188,989	7,127,332		(73,566,505	)	3,749,816
Transactions with owners in their capacity as owners:
Issuance of shares in connection with private placement, net of costs		12(b)	30,750,000	4,798,800	-		-		4,798,801
Issuance of options in connection with private placement		12(c)	-	-	857,143		-		857,143
Non-cash issuance of shares to consultants		12(b)	165,000	42,267	-		-		24,750
Non-cash issuance of options to consultants		13(b)	-	-	409,299		-		409,299
Non-cash issuance of options to directors and employees		13(b)	-	-	63,962		-		63,962
Issuance of shares in connection with exercise of options, net of costs	12(b) & 13(b)		420,398	90,108	(90,108	)	-		-
Share options – value of share option scheme		13(b)	-	-	214,951		-		214,951
			31,335,398	4,931,175	1,455,247		-		6,386,422
Net loss		14	-	-	-		(4,906,922	)	(4,906,922	)
Total comprehensive income for the year			-	-	-		(4,906,922	)	(4,906,922	)
Balance, June 30, 2010			234,045,871	75,120,164	8,582,579		(78,473,427	)	5,229,316

The accompanying notes are an integral part of the consolidated financial statements.

F - 5

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -– in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES~~

Background

Prana Biotechnology Limited and its controlled entities: Prana Biotechnology Inc. and Prana Biotechnology UK Limited (referred to collectively as “Prana” or the “consolidated entity”) is a development stage enterprise engaged in the research and development of therapeutic drugs designed to treat the underlying cause of degeneration of the brain and the eye as the aging process progresses. Prana Biotechnology Limited (the “Company”), the parent entity was incorporated on November 11, 1997 in Melbourne, Australia. The UK and U.S. subsidiaries were incorporated in August 2004.

Financial Reporting Framework

The financial report of Prana Biotechnology Limited for the year ended June 30, ~~2009~~2010 was authorized for issue in accordance with a resolution of the Directors on September ~~23, 2009.~~

30, 2010.

The financial report is a general purpose financial report, which has been prepared in accordance with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board (“IASB”), theCorporations Act 2001, Accounting Standards and Urgent Issues Group Interpretations, and complies with other requirements of applicable law. This financial report complies with both IFRS as issued by IASB and Australian equivalents to IFRS.

The financial report has been prepared on the basis of historical cost. Cost is based on the fair value of the consideration given in exchange for assets.

Accounting policies are selected and applied in a manner which ensures that the resulting financial information satisfies the concepts of relevance and reliability, thereby ensuring that the substance of the underlying transactions or other events is reported.

The accounting policies set out below have been applied in preparing the financial statements for the year ended June 30, ~~2009~~2010 and the comparative information presented in these financial statements for the years ended June 30, ~~2008~~2009 and ~~2007.~~

2008.

Critical accounting estimates, judgments and assumptions

Estimates and judgments are continually evaluated and are based on historical experience and other factors, including expectations of future events that may have a financial impact on the entity and that are believed to be reasonable under the circumstances.

The consolidated entity makes estimates and assumptions concerning the future. The resulting accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next financial year are discussed below.

(a) Valuation of options with market vesting conditions

The consolidated entity has granted options that are exercisable into ordinary shares once the listed share price reaches a defined level for a specified number of consecutive trading days.

The consolidated entity considers the target share price that must be attained in order to exercise the awards to be a market condition.

The Company is unable to predict the ultimate success of research and development activities and the corresponding effect on the listed share price. However, the following assumptions have been made when valuing the options in relation to these market conditions:

1)	~~The market condition will be met as the listed share price will reach the defined share price during the life of the option; and~~

2)	~~Based on the best estimate of the consolidated entity, made during the 2006 fiscal year, the share price will reach the defined level:~~

1) The market condition will be met as the listed share price will reach the defined share price during the life of the option; and

2) Based on the best estimate of the consolidated entity, made during the 2006 fiscal year, the share price will reach the defined level:

> A$0.80 at June 30, 2009

> A$1.00 at June 30, 2010

3) Based on the best estimate of the consolidated entity, made during the 2009 fiscal year, the share price will reach the defined level:

> A$0.25 at June 30, 2009

> A$0.45 at June 30, 2010

4) Based on the best estimate of the consolidated entity, made during the 2010 fiscal year, the share price will reach the defined level:

> A$0.20 at June 30, 2010

> A$0.30 at June 30, 2011

> A$0.40 at June 30, 2012

~~A$0.80 at June 30, 2009~~

F - 6

~~A$1.00 at June 30, 2010~~

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

3)	~~Based on the best estimate of the consolidated entity, made during the 2009 fiscal year, the share price will reach the defined level:~~

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

~~A$0.25 at June 30, 2009~~

~~A$0.45 at June 30, 2010~~

The initial estimate made at the date of grant as regards to the likelihood of achieving the market condition is never adjusted for changes in the probability of the condition being achieved. At each reporting period, the Company assesses the estimated period over which the defined market condition will be achieved.

~~F - 6~~

~~PRANA BIOTECHNOLOGY LIMITED~~

~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

(b) Critical judgments in applying the entity’s accounting policies –- use of volatility period in valuing warrant liabilities

Warrants and options exercisable into American Depository Receipts ~~(“ADRs”~~("ADRs") recorded as financial liabilities under IAS 32Financial Instruments: Presentation (see Note 10) are measured at fair value using a Black-Scholes valuation model. At each reporting date any options and warrants for ADRs are recorded at fair value with the corresponding difference being recorded in the income statement as a gain or loss.

Warrants that were exercisable for ADRs expired without being exercised on June 4, 2009. Options for ADRs remain outstanding.

In using the Black-Scholes model to fair value these options and warrants for financial year 2008, the consolidated entity utilized a two year historical ADR price when calculating the volatility of the underlying ADRs. It is the judgment of the consolidated entity that a two year period provides the most appropriate history of ADR price over which a reasonable volatility input can be calculated.

Going Concern Basis

The consolidated entity is a development stage medical biotechnology company and as such, expects to be utilizing cash until its research and development activities have become marketable. As at 30 June ~~2009,~~2010, the consolidated entity had an operating loss of A$~~7,522,789 (2008~~4,906,922 (2009 loss: A$~~13,560,678)~~7,522,789). As at year end, the consolidated ~~entity’s~~entity's net assets amounted to A$~~3,749,816 (2008:~~5,229,316 (2009: A$~~9,866,327)~~3,749,816). The consolidated ~~entity’s~~entity's cash position has ~~decreased~~increased to A$5,227,298 at 30 June 2010 from A$4,304,977 at 30 June ~~2009~~2009.

There remains significant uncertainty of the Company’s ability to continue as a going concern for a further 12 months from ~~A$11,219,035~~the date of signing the financial report and, therefore, whether the Company will realize its assets and extinguish its liabilities in the normal course of business and at ~~30 June 2008.~~

~~The~~the amounts stated in the financial report. However, the Directors believe that the going concern basis of preparation is ~~appropriate. Subsequent~~appropriate given the funding expected from the following sources:

Since inception, the consolidated entity has been able to raise funds to pursue its research programs, raising in excess of A$85m through the issue of equity and warrants, before costs. In the past twelve months, the consolidated entity has demonstrated that it can raise capital by raising A$6,000,000 through the issue of equity, before costs. The Directors believe that there is an expectation that they can raise additional funding to enable the consolidated entity to continue to pursue the current business objectives and at the General Meeting held on 17 August 2010, received shareholder approval to issue 225,000,000 new ordinary shares to raise approximately A$27m, dependant on the final issue price.

Given the significant uncertainty of capital markets, other sources of funding to support the current business objectives are being pursued in parallel, including potential joint venture arrangements, merger, acquisition and other means of leveraging resources from potential partners to continue the business objectives of the consolidated entity over the next twelve months.

At this time, the Directors are of the opinion that no asset is likely to ~~year end~~be realized for an amount less than the amount at which it is recorded in the Statements of Financial Position at 30 June 2010. Therefore, no adjustments have been made to the financial report relating to the recoverability and classification of the asset carrying amounts or the classification of liabilities that might be necessary should the consolidated entity ~~raised $6 million of additional funding (refer to details in Note 18). This funding will enable the consolidated entity to~~not continue to pursue its current business objectives. Notwithstanding, the Company has the ability to scale down its operations and continue certain programs including research and discovery programs in Parkinson’s disease and vaccine program in Alzheimer’s disease, should the need arise.

as a going concern.

Development Stage – Risks and Uncertainties

As a development stage enterprise, the consolidated entity’s prospects are subject to the risks, expenses and uncertainties frequently encountered by companies which have not yet commercialized any applications of their technology, particularly in new and evolving markets. Prana’s operating results may fluctuate significantly in the future as a result of a variety of factors, including capital expenditure and other costs relating to establishing, maintaining and expanding the operations, the number and mix of potential customers, potential pricing of future products by the consolidated entity and its competitors, new technology introduced by the consolidated entity and its competitors, delays or expense in obtaining necessary equipment, economic and social conditions in the biotechnology industry and general ~~economic~~e conomic conditions.

Prana will continue to review the need to seek additional funding through public and private financing and/or through collaboration or other arrangements with corporate partners. The consolidated entity cannot be certain that it will be able to raise any required funding or capital, on favorable terms or at all, or that it will be able to establish corporate collaborations on acceptable terms, if at all. If the consolidated entity is unable to obtain such additional funding or capital, it may be required to reduce the scope of its development plans.

F - 7

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Prana’s experience in exploiting its technology is limited. The consolidated entity cannot be certain that its operations will be profitable in the short-term, or at all. If Prana fails in any of its efforts to establish or expand its business, the results of operations, financial condition and liquidity of the consolidated entity could be materially adversely affected. The consolidated entity cannot be certain that it will be able to obtain or retain any permits required by the consolidated entity to market, sell and deliver its technology. Any of these factors could result in the reduction or cessation of Prana’s operations.

Significant Accounting Policies

~~F - 7~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

The following significant accounting policies have been adopted in the preparation and presentation of the financial report.

(a)Principles of Consolidation

The consolidated financial statements are prepared by combining the financial statements of all the entities that comprise the consolidated entity, being the Company and its subsidiaries as defined in Accounting Standard IAS 27:Consolidated and Separate Financial Statements. Consistent accounting policies are employed in the preparation and presentation of the consolidated financial statements.

Subsidiaries are all those entities (including special purpose entities) over which the consolidated entity has the power to govern the financial and operating policies, generally accompanying a shareholder of more than one-half of the voting rights. The existence and effect of potential voting rights that are currently exercisable or convertible are considered when assessing whether the consolidated entity controls another entity.

Subsidiaries are fully consolidated from the date on which control is transferred to the consolidated entity. They are de-consolidated from the date that control ceases.

In preparing the consolidated financial statements, all inter-company balances and transactions, and unrealized profits/losses arising within the consolidated entity are eliminated in full. Investments in subsidiaries are accounted for at cost in the individual financial statements of the Company.

(b)Income Tax

Current tax

Current tax is calculated by reference to the amount of income taxes payable or recoverable in respect of the taxable profit or loss for the period. It is calculated using tax rates and tax laws that have been enacted or substantively enacted by reporting date. Current tax for current and prior periods is recognized as a liability (or asset) to the extent that it is unpaid (or refundable).

Deferred tax

Deferred tax is accounted for using the comprehensive balance sheet liability method in respect of temporary differences arising from differences between the carrying amount of assets and liabilities in the financial statements and the corresponding tax base of those items.

In principle, deferred tax liabilities are recognized for all taxable temporary differences. Deferred tax assets are recognized to the extent that it is probable that sufficient taxable amounts will be available against which deductible temporary differences or unused tax losses and tax offsets can be utilized. However, deferred tax assets and liabilities are not recognized if the temporary differences giving rise to them arise from the initial recognition of assets and liabilities (other than as a result of a business combination) which affects neither taxable income nor accounting profit or loss.

Deferred tax liabilities are recognized for taxable temporary differences arising on investments in subsidiaries except where the consolidated entity is able to control the reversal of the temporary differences and it is probable that the temporary differences will not reverse in the foreseeable future. Deferred tax assets arising from deductible temporary differences associated with these investments are only recognized to the extent that it is probable that there will be sufficient taxable profits against which to utilize the benefits of the temporary differences and they are expected to reverse in the foreseeable future.

Deferred tax assets and liabilities are measured at the tax rates that are expected to apply to the period(s) when the asset and liability giving rise to them are realized or settled, based on tax rates (and tax laws) that have been enacted or substantively enacted by reporting date. The measurement of deferred tax liabilities and assets reflects the tax consequences that would follow from the manner in which the consolidated entity expects, at the reporting date, to recover or settle the carrying amount of its assets and liabilities.

Deferred tax assets and liabilities are offset when they relate to income taxes levied by the same taxation authority and the Company/consolidated entity intends to settle its current tax assets and liabilities on a net basis.

F - 8

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Current and deferred tax for the period

Current and deferred tax is recognized as an expense or income in the statement of operations, except when it relates to items credited or debited directly to equity, in which case the deferred tax is also recognized directly in equity, or where it arises from the initial accounting for a business combination, in which case it is taken into account in the determination of goodwill.

The consolidated entity has significant unused tax losses and as such a significant deferred tax asset; however, the deferred tax asset has not been recognized, as it is not probable that future taxable profit will be available against which the unused losses and unused tax credits can be utilized, given the nature of the consolidated entity’s business (research and development) and its history of losses.

~~F - 8~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

(c)Property and Equipment

Property and equipment is measured at historical cost less accumulated depreciation and impairment and consists of laboratory equipment, computer equipment, furniture and fittings and leasehold improvements attributable to Prana’s premises at Parkville, Victoria, Australia.

Historical cost includes expenditure that is directly attributable to the acquisition of the item.

Subsequent costs are included in the ~~asset’s~~asset's carrying amount or ~~recognised~~recognized as a separate asset, as appropriate, only when it is probable that future economic benefits associated with the item will flow to the consolidated entity and the cost of the item can be measured reliably. The carrying amount of any component accounted for as a separate asset is derecognized when replaced. All other repairs and maintenance are charged to the income statement during the reporting period in which they are incurred.

Depreciation

Depreciation is provided on property and equipment. Depreciation is calculated on a straight-line method to allocate their cost, net of their residual values, over their estimated useful lives.

The following estimated useful lives, ranging from three to 20 years are used in the calculation of depreciation:

Class of Fixed AssetDepreciation Rate


	Class of Fixed Asset				Depreciation Rate



Furniture and fittings		~~5-33~~	%			5-33%
Computer equipment		33	%			33%
Plant and equipment		~~10-33~~	%			10-33%
Leasehold improvements		33	%
				33%

Leasehold improvements are depreciated over the shorter of the lease term and useful life.

The depreciation method, residual values and useful lives are reviewed, and adjusted if appropriate, at each annual reporting period.

(d)Leases

Leases in which a significant proportion of the risks and rewards of ownership are not transferred to the Company as lessee are classified as operating leases.

Operating lease payments are recognized as an expense on a straight-line basis over the lease term, except where another systematic basis is more representative of the time pattern in which economic benefits from the leased assets are consumed.

(e)Financial Instruments

Loans and Receivables

Loans and receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market. They are included in current assets, except for those with maturities greater than 12 months after the reporting date which are classified as non-current assets. Loans and receivables are included in trade and other receivables in the balance sheet. Trade receivables, loans, and other receivables are recorded at amortized cost less impairment.

Warrants and Options

Under IAS 32, options and warrants issued other than for goods or services that are exercisable in a currency other than the functional currency of the Company and meet the definition of a liability are recorded as financial liabilities rather than equity. Refer to accounting policy (p) share-based payments for the accounting policy for warrants and options issued as share-based payments for goods or services.

Warrants and options recorded as financial liabilities under IAS 32 are valued at fair value using the Black-Scholes model. The expected life used in the model has been adjusted, based on management’s best estimate, for the effects of non-transferability, exercise restrictions, and behavioural considerations. At each reporting date, the options and warrants are revalued to their current fair value, with the difference in fair value recorded in the Income Statement.

F - 9

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

(f)Impairment of Assets

At each reporting date, the consolidated entity reviews the carrying amounts of its tangible and intangible assets to determine whether there is any indication that those assets have been impaired. If any such indication exists, the recoverable amount of the asset is estimated to determine the extent of the impairment loss (if any).

Where the asset does not generate cash flows that are independent from other assets, the consolidated entity estimates the recoverable amount of the cash-generating unit to which the asset belongs.

~~F - 9~~

~~PRANA BIOTECHNOLOGY LIMITED~~

~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

Intangible assets not yet available for use are tested for impairment annually and whenever there is an indication that the asset may be impaired.

~~Recoverable~~

The recoverable amount for the asset (or cash-generating unit) is the higher of fair value less costs to sell and value in use. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset for which the estimates of future cash flows have not been adjusted.

If the recoverable amount of an asset (or cash-generating unit) is estimated to be less than its carrying amount, the carrying amount of the asset (or cash-generating unit) is reduced to its recoverable amount. An impairment loss is recognized in profit or loss immediately.

Where an impairment loss subsequently reverses, the carrying amount of the asset (or cash-generating unit) is increased to the revised estimate of its recoverable amount, but only to the extent that the increased carrying amount does not exceed the carrying amount that would have been determined had no impairment loss been recognized for the asset (or cash-generating unit) in prior years. A reversal of an impairment loss is recognized in profit or loss immediately.

(g)Intangible Assets –- Research and Development

Expenditure during the research phase of a project is recognized as an expense when incurred. Where no internally generated intangible assets can be recognized, development expenditure is recognized as an expense in the period as incurred. Development costs are capitalized if and only if, all of the following are demonstrated:

—	~~the technical feasibility of completing the intangible asset so that it will be available for use or sale;~~

—	~~the intention to complete the intangible asset and use or sell it;~~

• the technical feasibility of completing the intangible asset so that it will be available for use or sale;

• the intention to complete the intangible asset and use or sell it;

• the ability to use or sell the intangible asset;

• how the intangible asset will generate probable future economic benefits;

• the availability of adequate technical, financial and other resources to complete the development and to use or sell the intangible asset; and

• the ability to measure reliably the expenditure attributable to the intangible asset during its development.

—	~~the ability to use or sell the intangible asset;~~

—	~~how the intangible asset will generate probable future economic benefits;~~

—	~~the availability of adequate technical, financial and other resources to complete the development and to use or sell the intangible asset; and~~

—	~~the ability to measure reliably the expenditure attributable to the intangible asset during its development.~~

Internally-generated intangible assets (capitalized development costs) are stated at cost less accumulated amortization and impairment, and are amortized on a straight-line basis over their useful lives over a maximum of five years.

At June 30, ~~2009~~2010 and ~~2008,~~2009, Prana had no capitalized research and development costs.

(h)Foreign Currency Transactions and Balances

Functional and Presentation Currency

Items included in the financial statements of each of the consolidated entity’s entities are measured using the currency of the primary economic environment in which the entity operates (the functional currency). The consolidated financial statements are presented in Australian dollars, which is Prana’s functional and presentation currency.

Foreign currency transactions

All foreign currency transactions during the financial year are brought to account using the exchange rate in effect at the date of the transaction. Foreign currency monetary items at each reporting date are translated at the exchange rate existing at each reporting date. Non-monetary assets and liabilities carried at fair value that are denominated in foreign currencies are translated at the rates prevailing at the date when the fair value was determined.

Exchange differences are recognized in profit or loss in the period in which they arise except for exchange differences on monetary items receivable from or payable to a foreign operation for which settlement is neither planned or likely to occur, which form part of the net investment in a foreign operation, are recognized in the foreign currency translation reserve and recognized in profit or loss on disposal of the net investment.

F - 10

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Group companies

The results and financial position of all the Company’s entities that have a functional currency difference from the presentation currency are translated into the presentation currency as follows:

—·	assets and liabilities for each balance sheet presented are translated at the closing rate at the date of that balance sheet, and

—·	income and expenses for each income statement are translated at average exchange rates (unless this is not a reasonable approximation of the cumulative effect of the rates prevailing on the transaction dates, in which case income and expenses are translated at the dates of the transactions), and

—·	all resulting exchange differences are recognized as a separate component of equity.

On consolidation, the assets and liabilities of the consolidated entity’s overseas operations are translated at exchange rates prevailing at the reporting date. Income and expense items are translated at the average exchange rates for the period unless exchange rates fluctuate significantly. Exchange differences arising, if any, are recognized in the foreign currency translation reserve, and recognized in profit or loss on disposal of the foreign operations.

~~F - 10~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

(i)Employee Benefits

Provision is made for the consolidated entity’s liability for employee benefits arising from services rendered by employees to reporting date. Employee benefits that are expected to be settled within one year have been measured at the amounts expected to be paid when the liability is settled, plus related on-costs.

Employee benefits payable later than one year have been measured at the present value of the estimated future cash outflows to be made for those benefits.

Consideration is given to expected future wage and salary levels and periods of service. Expected future payments are discounted using market yields at the reporting date on national government bonds with terms to maturity and currency that match, as closely as possible, the estimated future cash outflows.

(j)Provisions

Provisions are recognized when the consolidated entity has a present obligation, the future sacrifice of economic benefits is probable, and the amount of the provision can be measured reliably.

The amount recognized as a provision is the best estimate of the consideration required to settle the present obligation at reporting date, taking into account the risks and uncertainties surrounding the obligation. Where a provision is measured using the cash flows estimated to settle the present obligation, its carrying amount is the present value of those cash flows.

When some or all of the economic benefits required to settle a provision are expected to be recovered from a third party, the receivable is recognized as an asset if it is virtually certain that recovery will be received and the amount of the receivable can be measured reliably.

(k)Cash and Cash Equivalents

Cash and cash equivalents includes cash on hand, deposits held at call with banks and other short-term highly liquid investments with original maturities of three months or less.

(l)Revenue

Revenue is recognized to the extent that it is probable that the economic benefits will flow to the entity and the revenue can be reliably measured. Revenue is made up of interest income which is recognized on a time proportion basis using the effective interest method.

(m)Other Income

Other income is recognized to the extent that it is probable that the economic benefits will flow to the entity and the income can be reliably measured.

~~Government grants~~
Government grants are recorded as income when key milestones set within each agreement are achieved and accepted by all parties to the grant. The agreements comprise different phases based on product development. Milestones are based on the phases of each product development, for example Phase 1, Phase 2 and Phase 3. Other income is not recognized prior to acceptance that the milestones have been achieved, as collectability is not assured until this point is reached. Once each milestone is reached and approved, the grantor is obligated to pay and there are no further significant obligations as to that part of the milestone. Grant income for achievement of such milestones is agreed between the parties in legally binding contracts. Income for each milestone achieved is fixed up front.

(n)Goods and Services Tax (“GST”)

Revenues, expenses and assets are ~~recognised~~recognized net of the amount of GST, except where the amount of GST incurred is not recoverable from the taxation authority. In these circumstances the GST is ~~recognised~~recognized as part of the cost of acquisition of the asset or as part of an item of expense. Receivables and payables in the Balance Sheet are shown inclusive of GST.

The net amount of GST recoverable from, or payable to, the taxation authority is included as part of receivables or payables.

Cash flows are included in the Cash Flow Statement on a gross basis. The GST component of cash flows arising from investing and financing activities which is recoverable from, or payable to, the taxation authority is classified as operating cash flows.

F - 11

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

(o)Trade and Other Payables

These amounts represent liabilities for goods and services provided to the consolidated entity prior to the end of financial year which are unpaid. The amounts are unsecured and are usually paid within 30 days of recognition.

~~F - 11~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

(p)Share-Based Payments

Equity-settled share-based payments granted after November 7, 2002 that were unvested as of January 1, 2005 are measured at fair value. The measurement date is determined for share-based payments issued to directors, employees and consultants as follows:

Directors

The issuance of share-based payments to directors is subject to approval by shareholders as per ASX Listing Rule 10.11. The measurement date for share-based payments issued to directors is the grant date, being the date at which the share-based payments are approved by shareholders.

Employees

The issuance of share-based payments to employees may be subject to shareholder approval per ASX Listing Rule 7.1 which prohibits the issuance of more than 15% of the Company’s shares in a 12 month period without shareholder approval. The measurement date for share-based payments issued to employees is the grant date, being the date at which a shared understanding of the terms and conditions of the arrangement is reached. However, if an issuance to an employee is subject to shareholder approval because it exceeds the 15% threshold per ASX Listing Rule 7.1, then the measurement date of these share-based payments is the date at which the share-based payments are approved by shareholders.

Consultants

The issuance of share-based payments to consultants may be subject to shareholder approval per ASX Listing Rule 7.1 which prohibits the issuance of more than 15% of the Company’s shares in a 12 month period without shareholder approval. The measurement date for share-based payments issued to consultants who provide services considered to be similar to employees is deemed to be the date at which a shared understanding of the terms and conditions of the arrangement is reached. The measurement date for share-based payments issued to consultants who provide services considered to be differentiated from those provided by employees is deemed to be the date at which the entity obtains the goods or the counterparty renders the service. If a service period applies and the work is continually provided ~~over~~ov er the service period, and if the share price of the Company does not change significantly during the service period, then the average share price, volatility and risk-free rate over the service period are used in calculating the value of the share-based payments issued. However, if the underlying share price of the Company does change significantly during the service period, then the value of share-based payments are calculated at each individual date that goods and services are provided, using the actual valuation inputs at that date. Shares issued to consultants for services are recorded as non-cash compensation and are recognized at either the fair value of the services rendered, or if this cannot be reasonably estimated, the fair value of the underlying equity instruments issued.

Equity-based compensation benefits are provided to directors, employees and consultants under the 2004 ASX Plan (the “2004 ASX Plan”) and the 2004 American Depository Share (ADS) Option Plan (the “2004 ADS Plan”). Information relating to this plan is set out in Note 17.

The fair value of options granted under the 2004 ASX Plan is recognized as an expense with a corresponding increase in equity. The fair value is measured at grant date and recognized over the period during which the recipients become unconditionally entitled to the options.

The fair value at grant date is independently determined using a Black-Scholes (for options without market condition) and Barrier Pricing (for options with market conditions) model that takes into account the exercise price, the term of the option, the impact of dilution, the share price at grant date and expected price volatility of the underlying share, the expected dividend yield and the risk free interest rate for the term of the option. The expected life used in the model has been adjusted, based on ~~management’s~~management's best estimate, for the effects of non-transferability, exercise restrictions, and behavioral considerations.

The fair value determined at the grant date of the equity-settled share-based payments is expensed on a straight-line basis over the vesting period, based on the consolidated ~~entity’s~~entity's estimate of shares that will eventually vest.

(q)Loss Per Share

Basic loss per share is determined by dividing the net loss after income tax expense by the weighted average number of ordinary shares outstanding during the financial period. For all periods presented, diluted loss per share is equivalent to basic loss per share as the potentially dilutive securities are excluded from the computation of diluted loss per share because the effect is anti-dilutive.

(r)Share Capital

Ordinary share capital is recognized as the fair value of the consideration received by the Company. Any transaction costs arising on the issue of ordinary shares are recognized directly in equity as a reduction of the share proceeds received.

(s)Trade and Other Receivables

Trade and other receivables are recognized initially at fair value and subsequently measured at amortized cost using the effective interest rate method less provision for impairment.

F - 12

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1. BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

(t)Comparative Figures

When required by IFRS, comparative figures have been adjusted to conform with changes in presentation for the current financial year.

~~F - 12~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -~~(u)Parent Information

The financial information for the parent entity, Prana Biotechnology Limited, disclosed in ~~Australian dollars (unless otherwise noted)~~

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

Note 2 has been prepared on the same basis as the consolidated financial statements, except as set out below.

Investment in Subsidiaries

Investments in subsidiaries are accounted for at cost in the financial statements of Prana Biotechnology Limited.

~~(u)~~ (v)New Accounting Standards And Interpretations

In respect of the year ended 30 June 2010, the Group has assessed all new accounting standards mandatory for adoption during the current year, noting no new standards which would have a material affect on the disclosure in these financial statements. There has been no affect on the profit and loss or the financial position of the Group.

Certain new ~~International~~ accounting standards and interpretations have been published that are not mandatory for 30 June ~~30, 2009~~2010 reporting periods. ~~Based on~~The Group’s and the ~~Company’s~~parent entity’s assessment ~~it believes that~~of the ~~following~~impact of these new standards and interpretations ~~could~~is set out below.

Ø	IFRS 2009-8 Amendments to International Accounting Standards – Group Cash-Settled Share-Based Payment Transactions [IFRS 2] (effective for all accounting periods commencing on or after 1 January 2010)

The amendments made by the IASC to IFRS 2 confirm that an entity receiving goods or services in a group share-based payment arrangement must recognise an expense for those goods or services regardless of which entity in the ~~future have~~group settles the transaction or whether the transaction is settled in shares or cash. They also clarify how the group share-based payment arrangement should be measured, that is, whether it is measured as an equity- or a cash-settled transaction. The Group will apply these amendments retrospectively for the financial reporting period commencing on 1 July 2010. There will be no impact on ~~its consolidated~~the Group’s financial statements.

Ø	IFRS 2009-10 Amendments to International Accounting Standards – Classification of Rights Issues [IAS 32 (effective for all accounting periods commencing on or after 1 February 2010)

In October 2009, the IASC issued an amendment to IAS ~~23 (Amendment), “Borrowing costs” (effective~~32 Financial Instruments: Presentation which addresses the accounting for ~~annual~~rights issues that are denominated in a currency other than the functional currency of the issuer. Provided certain conditions are met, such rights issues are now classified as equity regardless of the currency in which the exercise price is denominated. Previously, these issues had to be accounted for as derivative liabilities. The amendment must be applied retrospectively in accordance with IAS 8 Accounting Policies, Changes in Accounting Estimates and Errors. The Group will apply the amended standard from 1 July 2010. As the Group has not made any such rights issues, the amendment will not have any effect on the Group’s financial statements.

Ø	IFRS 7 Financial Instruments and IFRS 2009-11 Amendments to International Accounting Standards arising from IFRS 7 (effective from 1 January 2013)

IFRS 7 Financial Instruments addresses the classification and measurement of financial assets and is likely to affect the group’s accounting for its financial assets. The standard is not applicable until 1 January 2013 but is available for early adoption. The Group is yet to assess its full impact. However, initial indications are that it may affect the Group’s accounting for its available-for-sale financial assets, since IFRS 7 only permits the recognition of fair value gains and losses in other comprehensive income if they relate to equity investments that are not held for trading. Fair value gains and losses on available-for-sale debt investments, for example, will therefore have to be recognised directly in profit or loss. In the current reporting period, the Gr oup recognised no such gains or losses in other comprehensive income. The Group has not yet decided when to adopt IFRS 7.

Ø	Revised IAS 24 Related Party Disclosures and IFRS 2009-12 Amendments to International Accounting Standards (effective from 1 January 2011)

In December 2009, the IASC issued a revised IAS 24 Related Party Disclosures. It is effective for accounting periods beginning on or after 1 January 2011 and must be applied retrospectively. The amendment removes the requirement for government-related entities to disclose details of all transactions with the government and other government-related entities and clarifies and simplifies the definition of a related party. The group will apply the amended standard from 1 ~~2009~~July 2011. When the amendments are applied, the Group and ~~applicable~~the parent entity will need to disclose any transactions between its subsidiaries and its associates. The Company’s only transactions with government-related entities specifically relate to grants and research and development performed by public hospitals, no oth er government-related transactions have occurred. It is therefore not possible to disclose the financial impact, if any, of the amendment on the related party disclosures.

F - 13

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

1.BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Ø	IFRIC Interpretation 19 Extinguishing financial liabilities with equity instruments and IFRS 2009-13 Amendments to International Accounting Standards arising from Interpretation 19 (effective from 1 July 2010)

IFRIC Interpretation 19 clarifies the accounting when an entity renegotiates the terms of its debt with the result that the liability is extinguished by the debtor issuing its own equity instruments to the ~~Company effective July 1, 2009)~~creditor (debt for equity swap). ~~The amendment~~ It requires ~~an entity~~a gain or loss to ~~capitalize borrowing costs directly attributable to~~be recognised in profit or loss which is measured as the ~~acquisition, construction or production of a qualifying asset (one that takes a substantial period of time to get ready for use or sale) as part~~difference between the carrying amount of the ~~cost of that asset. The option of immediately expensing those borrowing costs will be removed. IAS 23 (Amendment) is not expected to have an impact on~~financial liability and the ~~Company’s financial statements as it has no qualifying assets.~~

~~IAS 1 (Revised), “Presentation of financial statements” (effective for annual periods beginning on or after January 1, 2009 and applicable to the Company effective July 1, 2009)~~.The revised standard will prohibit the presentation of items of income and expenses (that is, ‘non-owner changes in equity’) in the statement of changes in equity, requiring ‘non-owner changes in equity’ to be presented separately from owner changes in equity. All non-owner changes in equity will be required to be shown in a performance statement, but entities can choose whether to present one performance statement (the statement of comprehensive income) or two statements (the income statement and statement of comprehensive income). Where entities restate or reclassify comparative information, they will be required to present a restated balance sheet as at the beginning comparative period in addition to the current requirement to present balance sheets at the endfair value of the ~~current period and comparative period. These amendments are only expected to affect~~equity instruments issued. The Group will apply the presentation of the Company’s financial statements and will not have a direct impact on the measurement and recognition of amounts disclosed in the financial statements. The Company anticipates that it will present a single Statement of Comprehensive Income rather than two separate statements due to the minimum number of items expected to be classified as Other Comprehensive Income.

~~IFRS 2 (Amendment), “Share-based payment” (effective for annual periods beginning on or after January~~interpretation from 1 ~~2009 and applicable to the Company effective~~ July ~~1, 2009).~~ ~~The amended standard deals with vesting conditions and cancellations.~~2010. It clarifies that vesting conditions are service conditions and performance conditions only. Other features of a share-based payment are not vesting conditions. These features would need to be included in the grant date fair value for transactions with employees and others providing similar services; they would not impact the number of awards expected to vest or valuation there of subsequent to grant date. All cancellations, whether by the Company or by other parties, should receive the same accounting treatment. The Company has share-based payment arrangements with vesting conditions as defined under this standard; therefore these amendments are not expected to have any impact on its financial statements.

IAS 32 (Amendment), “Financial instruments: Presentation,” and IAS 1 (Amendment), “Presentation of financial statements – Puttable financial instruments and obligations arising on liquidation” (effective for annual periods beginning on or after January 1, 2009 and applicable to the Company effective July 1, 2009). The amended standards require entities to classify puttable financial instruments and instruments, or components of instruments that impose on the entity an obligation to deliver to another party a pro rata share of the net assets of the entity only on liquidation as equity, provided the financial instruments have particular features and meet specific conditions. These amendments areis not expected to have any impact on the ~~Company’s~~Group’s or the parent entity’s financial statements assince it is only retrospectively applied from the beginning of the earliest period presented (1 July 2009) and the group has not ~~issued puttable financial instruments as defined by~~entered into any debt for equity swaps since that date.

Ø	IFRS 2009-14 Amendments to International Interpretation – Prepayments of a Minimum Funding Requirement (effective from 1 January 2011)

In December 2009, the ~~amendments.~~

~~IAS 27 (Revised), “Consolidated~~IASC made an amendment to Interpretation 14: The Limit on a Defined Benefit Asset, Minimum Funding Requirements and ~~separate financial statements” (effective for annual periods beginning on or after January 1, 2009 and applicable~~their Interaction. The amendment removes an unintended consequence of the interpretation related to voluntary prepayments when there is a minimum funding requirement in regard to the ~~Company effective July 1, 2009).~~entity’s defined benefit scheme. It permits entities to recognise an asset for a prepayment of contributions made to cover minimum funding requirements. The ~~revised standard requires the effects of all transactions with non-controlling interests to be recorded in equity if there~~group does not make any such prepayments. The amendment is no change in control and these transactions will no longer result in goodwill or gains and losses. The standard also specifies the accounting when control is lost. Any remaining interest in the entity is re-measured to fair value, and a gain or loss is recognized in profit or loss. The Company began to apply IAS 27 (Revised) prospectively to transactions with non-controlling interests from July 1, 2009.

~~IFRS 3 (Revised), “Business combinations” (effective for annual periods beginning on or after January 1, 2009 and applicable to the Company effective July 1, 2009).~~The revised standard continues to apply the acquisition method to business combinations, with some significant changes. For example, all payments to purchase a business are to be recorded at fair value at the acquisition date, with contingent payments classified as debt subsequently re-measured through the income statement. There is a choice on an acquisition-by-acquisition basis to measure the non-controlling interest in the acquiree either at fair vale or at the non-controlling interest’s proportionate share of the acquiree’s net assets. All acquisition-related costs should be expensed. The Company began to apply IFRS 3 (Revised) prospectively to all business combinations from July 1, 2009. These amendments are only expected to affect the presentation of the Company’s financial statements and will not have a direct impact on the measurement and recognition of amounts disclosed in the financial statements. These amendments aretherefore not expected to have any impact on the ~~Company’s~~Group’s financial ~~statements as it does not have any business combinations.~~

~~IAS 23 (Amendment), “Borrowing costs” (effective for annual periods beginning on or after January~~statements. The Group intends to apply the amendment from 1 ~~2009 and applicable~~July 2011.

These are the only changes which are expected to be of relevance to the ~~Company effective July 1, 2009).~~ The amendment is part of the IASB’s annual improvements project published in May 2008. The definition of borrowing costs has been amended so that interest expense is calculated using the effective interest method defined in IAS 39 “~~Financial instruments: Recognition and~~~~measurement.” This eliminates the inconsistency of terms between IAS 39 and IAS 23.~~

Group.

	Years Ended June 30,
	2010			2009			2008

2.PARENT INFORMATION
The following information has been extracted from the books and records of the parent and has been prepared in accordance with the company’s accounting policies.
Balance Sheet
ASSETS
Current Assets		6,707,726			4,490,936			11,594,001
Non-current Assets		95,106			107,729			105,727
TOTAL ASSETS		6,802,832			4,598,665			11,699,728

LIABILITIES
Current Liabilities		1,499,354			797,685			1,741,584
Non-current Liabilities		71,610			48,389			89,361
TOTAL LIABILITIES		1,570,964			846,074			1,830,945

EQUITY
Issued Capital		75,120,164			70,188,989			69,842,303
Reserves		8,582,579			7,127,332			6,067,740
Accumulated losses		(78,470,875	)		(73,563,730	)		(66,041,260	)
TOTAL EQUITY		5,231,868			3,752,591			9,868,783

Statement of Comprehensive Income
Total profit		(4,907,145	)		(7,522,470	)		(13,562,583	)
Total comprehensive income		(4,907,145	)		(7,522,470	)		(13,562,583	)

	Years Ended June 30,
	2010		2009		2008

3.REVENUE AND OTHER INCOME FROM CONTINUING OPERATIONS
Other revenue
Interest		215,008		428,193		490,943
Total other revenue		215,008		428,193		490,943

Other income
Other income		-		-		170
Total other income		-		-		170

F - 13

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -– in Australian dollars (unless otherwise noted)

			Years Ended June 30,
	Notes		2010		2009			2008
4.EXPENSES FROM ORDINARY ACTIVITIES
Research and development		4(a)		87,992		2,215,358			5,757,168

Personnel expenses
Employees				1,286,094		1,359,887			1,317,782
Equity based payments – employees				118,228		169,043			329,588
Consultants and directors				923,472		1,022,227			1,398,849
Equity-based payments – consultants and directors				612,252		1,136,428			2,152,234
Defined contribution superannuation expenses				147,188		145,219			151,736

Total personnel expense*				3,087,234		3,832,804			5,350,189

Intellectual property expenses
Overseas				202,002		497,947			140,705
Local				229,080		609,587			328,723

Total intellectual property expense
				431,082		1,107,534			469,428

Depreciation of non-current assets
Laboratory equipment				3,899		1,748			4,362
Computer equipment				26,997		26,488			16,152
Furniture and fittings				2,700		2,688			3,383
Leasehold improvements				1,420		1,420			1,452
Write-off non-current assets				274		1,846			-

Total depreciation expense				35,290		34,190			25,349

Other expenses
Corporate compliance				284,156		299,250			218,435
Office expenses				433,818		444,579			455,010
Computer expenses				21,167		23,178			34,794
Insurance				61,359		77,166			130,175
Office rental under operating lease				140,199		134,702			136,990

Total other expenses				940,699		978,875			975,404

Auditor and accounting expenses				168,909		129,998			331,950
Travel expenses				234,555		195,251			146,651
Public relations and marketing expenses				130,090		222,679			141,337
Foreign exchange gain				6,079		6,723			402,886
Gain (loss) on fair valuation of financial liabilities				-		(772,430	)		451,429

Total expenses				5,121,930		7,950,982			14,051,791
*Personnel expenses include salaries and fees paid to employees and consultants involved in research and development activities.

	Years Ended June 30,
4(a) Research and development expenses		2010	2009	2008
Personnel expenses related to research and development		578,389	812,086	1,471,357
Research and development expenses 1		87,992	2,215,358	5,757,168
Total Research and development expenses		666,381	3,027,444	7,228,525

1.	~~BACKGROUND AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)~~

~~IAS 28 (Amendment), “Investments in associates” (and consequential amendments to IAS 32, “Financial Instruments: Presentation,”~~Research and ~~IFRS 7, “Financial instruments: Disclosures”) effective~~development expenses consist of expenses paid for ~~annual periods beginning~~contracted research and development activities conducted by third parties on ~~or after January 1, 2009 and applicable to~~behalf of the Company.

For the year ended 30 June 2010, the Company ~~effective July 1, 2009).~~ ~~The amendment~~incurred research and development expenses of A$2,340,377. Such expenses were offset by cash that the Company received or is part of the IASB’s annual improvements project published in May 2008. An investment in an associate is treated as a single asset for the purposes of impairment testing. Any impairment loss is not allocatedreceivable, due to ~~specific assets included within the investment, for example, goodwill. Reversals of impairment are recorded as~~ an adjustment ~~to the investment balance to the extent that the recoverable amount of the associate increases. The Company has two inactive subsidiaries~~under a research and ~~does not have any jointly controlled entities or associates and therefore its financial statements are not expected to be impacted by this standard change.~~

~~IAS 19 (Amendment), “Employee benefits” (effective for annual periods beginning on or after January 1, 2009 and applicable to the Company effective July 1, 2009).~~~~The amendment is part of the IASB’s annual improvements project published in May 2008. The amendment clarifies that a plan amendment that results in a change~~development contract, resulting in the extent to which benefit promises are affected by future salary increases is a curtailment, while an amendment that changes benefits attributable to past service gives rise to a negative past service cost if it results in a reduction in the present valueline item of the defined benefit obligation. The definition of return on plan assets has been amended to state that plan administration costs are deducted in the calculation of return on plan assets only to the extent thatresearch and development expenses for such costs have been excluded from measurement of the defined benefit obligation. The distinction between short term and long term employee benefits will be based on whether benefits are due to be settled within or after 12 months of employee serviceperiod being ~~rendered. IAS 37, “~~~~Provisions, contingent liabilities and contingent assets~~~~,” requires contingent liabilities to be disclosed, not recognized. IAS 19 has been amended to be consistent.~~~~IAS 1 (Amendment), “Presentation of financial statements” (application date of standard January1, 2009; application date for Comopany July 1, 2009).~~ The amendment is part of the IASB’s annual improvements project published in May 2008. The amendment clarifies that some rather than all financial assets and liabilities classified as held for trading in accordance with IAS 39, “~~Financial instruments: Recognition and measurement~~~~” are examples of current assets and liabilities respectively. IAS 39 (Amendment) is not expected to have an impact on the Company’s financial statements.~~

~~There are a number of minor amendments to IFRS 7, “~~~~Financial instruments: Disclosures~~~~,” IAS 8, “~~~~Accounting policies, changes in accounting estimates and errors~~~~,” IAS 10, “~~~~Events after the reporting period~~~~,” IAS 18, “~~~~Revenue~~~~” and IAS 34, “~~~~Interim financial reporting~~,” which are part of the IASB’s annual improvements project published in May 2008 (not addressed above). These amendments are unlikely to have an impact on the Company’s financial statements and have therefore have not been described in further detail.

~~IFRIC 16, “Hedges of a net investment in a foreign operation” (effective for annual periods beginning on or after January 1, 2009 and applicable to the Company effective July 1, 2009).~~ IFRIC 16 clarifies the accounting treatment in respect of net investment hedging. This includes the fact that net investment hedging relates to differences in functional currency not presentation currency, and hedging instruments may be held anywhere in the group. The requirements of IAS 21, “~~The effects of changes in foreign exchange rates~~~~,” apply to the hedged item. IFRIC 16 is not expected to have a material impact on the Company’s financial statements.~~

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~	~~2007~~



2.	~~REVENUE AND OTHER INCOME~~
	~~FROM CONTINUING OPERATIONS~~

Other revenue
Interest 428,193 490,943 507,150
Total other revenue 428,193 490,943 507,150

Other income
Other income - 170 287
Total other income - 170 287
A$87,992.

F - 14

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -– in Australian dollars (unless otherwise noted)

	Years Ended June 30,
	2010			2009			2008
5.INCOME TAX

(a) The prima facie tax on net (loss) before tax is reconciled to the income tax is as follows:
Prima facie tax income on net (loss) before income tax at 30% (2009 & 2008: 30%)		(1,472,077	)		(2,256,837	)		(4,068,203	)
Effect of lower tax rates of tax on overseas income		(34	)		48			(286	)

Add tax effect of:
(Over) provision of income tax in previous year relating to a correction of estimates 1		(133,538	)		13,806			(288	)
Equity issued for nil consideration		219,144			391,641			744,547
Research and development tax concession		(44,027	)		(258,131	)		(552,400	)
Gain on fair value of financial liabilities		-			(231,729	)		135,429
Other		1,426			1,701			116

Deferred tax asset not recognized		1,429,106			2,339,501			3,740,797

Income tax expense attributable to loss before income tax		-			-			-

(b) Potential deferred tax asset at June 30, 2010, 2009 and 2008 in respect of tax losses not brought to account is:		30,238,852			28,809,746			26,396,277
Temporary Differences		(230,014	)		246,714			1,242,278

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~	~~2007~~



3.	~~EXPENSES FROM ORDINARY ACTIVITIES~~

Research and development 2,215,358 5,757,168 4,492,193

Personnel expenses
    Employees 1,359,887 1,317,782 1,308,920
    Equity based payments - employees 169,043 329,588 753,484
    Consultants and directors 1,022,227 1,398,849 1,506,378
    Equity-based payments - consultants and
    directors 1,136,428 2,152,234 825,649
    Defined contribution superannuation expenses 145,219 151,736 160,300

Total personnel expense 3,832,804 5,350,189 4,554,731

Intellectual property expenses
    Overseas 497,947 140,705 229,256
    Local 609,587 328,723 370,976

Total intellectual property expense 1,107,534 469,428 600,232

Depreciation of non-current assets
    Laboratory equipment 1,748 4,362 11,581
    Computer equipment 26,488 16,152 22,757
    Furniture and fittings 2,688 3,383 3,068
    Leasehold improvements 1,420 1,452 21,176
    Write-off non-current assets 1,846 - -

Total depreciation expense 34,190 25,349 58,582

Other expenses
    Corporate compliance 299,250 218,435 231,883
    Office expenses 444,579 455,010 494,782
    Computer expenses 23,178 34,794 22,328
    Insurance 77,166 130,175 147,909
    Office rental under operating lease 134,702 136,990 111,661

Total other expenses 978,875 975,404 1,008,563

Auditor and accounting expenses 129,998 331,950 260,117
Travel expenses 195,251 146,651 309,997
Public relations and marketing expenses 222,679 141,337 215,455
Foreign exchange gain 6,723 402,886 757,578
Gain (loss) on fair valuation of financial
liabilities (772,430 ) 451,429 (607,691 )

Total expenses 7,950,982 14,051,791 11,649,757

~~F - 15~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - in Australian dollars (unless otherwise noted)~~

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~	~~2007~~



4.	~~INCOME TAX~~

(a)    The prima facie tax on net (loss) before tax
is reconciled to the income tax is as follows:
Prima facie tax income on net (loss) before
income tax at 30%
(2008 & 2007: 30%) (2,256,837 ) (4,068,203 ) (3,342,696 )
Effect of lower tax rates of tax on overseas
income 48 (286 ) 442

Add tax effect of:
(Over) provision of income tax in previous year
relating to a correction of estimates¹ 13,806 (288 ) (2,697,461 )
Equity issued for nil consideration 391,641 744,547 473,740
Research and development tax concession (258,131 ) (552,400 ) (434,117 )
Gain on fair value of financial liabilities (231,729 ) 135,429 (182,307 )
Other 1,701 116 2,452

Deferred tax asset not recognized 2,339,501 3,740,797 6,179,947

Income tax expense attributable to loss before
income tax - - -

(b)    Potential deferred tax asset at June 30,
2009, 2008 and 2007 in respect of tax losses not
brought to account is: 28,809,746 26,396,277 22,693,134
     Temporary Differences 246,714 1,242,278 392,720

¹ This is the result of the difference between the accounting estimate included in the prior year’s tax note, as disclosed in the Form 20-F for the year ended June 30, ~~2008,~~2009, and the tax return lodged with the Australian Tax Office after the filing of the Form 20-F for such period.

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~



5.	~~TRADE AND OTHER RECEIVABLES~~

Accrued income 526 89,569
Goods and services tax receivable - 31,072

526 120,641

	Years Ended June 30,
	2010		2009
6.TRADE AND OTHER RECEIVABLES

Accrued income		825		526

		825		526

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~



6.	~~OTHER ASSETS~~

Current
Prepayments 185,433 243,261
Term Deposit - 11,064

Total 185,433 254,325

Non-current
Term Deposit 35,164 35,164

Total 35,164 35,164

	Years Ended June 30,
	2010		2009
7.OTHER ASSETS
Current
Prepayments		72,892		185,433
Other Receivable*		1,406,711		-

Total		1,479,603		185,433

Non-current
Term Deposit		35,164		35,164

Total		35,164		35,164

*Refer to Note 4a for further details in relation to other receivables.

F - 16

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -– in Australian dollars (unless otherwise noted)

			~~Years Ended June 30,~~
		~~Notes~~	~~2009~~	~~2008~~



7.	~~PROPERTY AND EQUIPMENT~~

Gross carrying amount
Balance at beginning of year 646,399 599,793
Additions 36,191 46,606
Disposals (86,162 ) -

Balance at end of year 596,428 646,399

Accumulated depreciation
Balance at beginning of year (577,250 ) (551,902 )
Disposals 84,316 -
Depreciation expense 4 (32,344 ) (25,349 )

Balance at end of year (525,278 ) (577,251 )

Net book value at end of year 71,150 69,148

			Years Ended June 30,
	Notes		2010			2009
8.PROPERTY AND EQUIPMENT

Gross carrying amount
Balance at beginning of year				596,428			646,399
Additions				22,665			36,191
Disposals				(225,781	)		(86,162	)

Balance at end of year				393,312			596,428

Accumulated depreciation
Balance at beginning of year				(525,278	)		(577,250	)
Disposals				225,509			84,316
Depreciation expense		4		(35,016	)		(32,344	)

Balance at end of year				(334,785	)		(525,278	)

Net book value at end of year				58,527			71,150

Aggregate depreciation allocated during the year is recognized as an expense and disclosed in Note 3.

Years Ended June 30,
2009
2008

Laboratory equipment, at cost 369,959 369,730
Less accumulated depreciation (366,894 ) (367,082 )

Total laboratory equipment 3,065 2,648

Computer equipment, at cost 108,704 157,259
Less accumulated depreciation (63,655 ) (117,902 )

Total computer equipment 45,049 39,357

Furniture and fittings, at cost 42,595 43,751
Less accumulated depreciation (21,053 ) (19,521 )

Total furniture and fittings 21,542 24,230

Leasehold improvements, at cost 75,659 75,659
Less accumulated depreciation (74,165 ) (72,746 )

Total leasehold improvements 1,494 2,913

Total 71,150 69,148
4.

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~



8.	~~TRADE AND OTHER PAYABLES~~

Trade creditors 109,871 172,204
Accrued research and development expenses 248,304 419,244
Accrued intellectual property expenses 111,217 19,313
Accrued personnel expenses 246 657
Accrued audit fees 124,069 122,993
Accrued marketing expenses - 54,939
Other accrued expenses 10,435 59,763

Total 604,142 849,113

	Years Ended June 30,
	2010			2009

Laboratory equipment, at cost		166,165			369,959
Less accumulated depreciation		(151,739	)		(366,894	)

Total laboratory equipment		14,426			3,065

Computer equipment, at cost		109,071			108,704
Less accumulated depreciation		(84,197	)		(63,655	)

Total computer equipment		24,874			45,049

Furniture and fittings, at cost		37,278			42,595
Less accumulated depreciation		(18,125	)		(21,053	)

Total furniture and fittings		19,153			21,542

Leasehold improvements, at cost		75,659			75,659
Less accumulated depreciation		(75,585	)		(74,165	)

Total leasehold improvements		74			1,494

Total		58,527			71,150

F - 17

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -– in Australian dollars (unless otherwise noted)

			~~Years Ended June 30,~~
		~~Notes~~	~~2009~~	~~2008~~



9.	~~PROVISIONS~~

	Years Ended June 30,
	2010		2009
9.TRADE AND OTHER PAYABLES

Trade creditors		279,752		109,871
Accrued research and development expenses		650,331		248,304
Accrued intellectual property expenses		20,719		111,217
Accrued personnel expenses		31,516		246
Accrued audit fees		114,686		124,069
Accrued travel expenses		8,295		-
Accrued marketing expenses		63,078		-
Other accrued expenses		9,270		10,435
Sundry payables		66,770		-

Total		1,244,417		604,142

Current
Annual leave 17 126,427 121,082
Long service leave¹ 68,476 -

Total 194,903 121,082

Non-Current
Long service leave 17 48,389 89,361

			Years Ended June 30,
	Notes		2010		2009
10.PROVISIONS

Current
Annual leave		17		171,789		126,427
Long service leave1				84,285		68,476

Total				256,074		194,903

Non-Current
Long service leave		17		71,610		48,389

A provision has been recognized for employee entitlements relating to long service leave. In calculating the present value of future cash flows in respect of long service leave, the probability of long service leave being taken is based on historical data. The measurement and recognition criteria relating to employee benefits have been included in Note 1 to this report.

¹ Amounts not expected to be settled within the next 12 months

The current provision for long service leave includes all unconditional entitlements where employees have completed the required period of service and also those where employees are entitled to pro-rata payments in certain circumstances.

The entire amount is presented as current, since the consolidated entity does not have an unconditional right to defer settlement. However, based on past experience, the consolidated entity does not expect all employees to take the full amount of accrued long service leave or require payment within the next 12 months. The following amounts reflect leave that is not to be expected to be taken or paid within the next 12 months.

~~Years Ended June 30,~~

~~2009~~

~~2008~~

~~Long service leave obligation expected~~

	Years Ended June 30,
	2010		2009

Long service leave obligation expected to be settled after 12 months		84,285		68,476

11. COMMITMENTS AND CONTINGENCIES

A contingent liability which was reported by the company in its last annual report, relating to be

~~settled after 12 months~~

~~68,476~~

		~~Years Ended June 30,~~
		~~2009~~	~~2008~~



~~10.~~	~~FINANCIAL LIABILITIES~~

~~Current~~
~~Warrants over ADRs~~	-	~~772,430~~

~~Following~~ a ~~meeting~~past employee matter, is no longer considered material.

There are no contingent assets or liabilities at the date of ~~shareholders on June 1, 2004,~~this report. The consolidated entity is not involved in any legal or arbitration proceedings and, so far as the ~~Company issued 4 million ADRs (1 ADR = 10 ordinary shares) and warrants~~Directors are aware, no such proceedings are pending or threatened against the company.

In respect of expenditure commitments, refer to purchase 3 million ADRs to U.S. investors. The U.S. investors acquired the ADRs at a price of USD 5.00 per ADR and also received a warrant to purchase 3 ADRs for each 4 ADRs purchased. The private placement raised USD 20 million (AUD 28.9 million) before costs. The warrants were exercisable for ADRs on or before June 4, 2009 at an exercise price of USD 8.00 per ADR. The warrants expired without being exercised on June 4, 2009.

Under IAS 32 paragraph 11, the warrants associated with this transaction are required to be classified as a Financial Liability, as opposed to Issued Capital, as a result of the warrants being exercisable in a foreign currency, that is a currency different to the functional currency of the Company.

During 2005 the International Financial Reporting Interpretations Committee (“IFRIC”) noted that based on the existing wording of IAS 32 (the International Financial Reporting Standards equivalent to AASB 132), any contract entered into by an entity to exchange a fixed number of its own equity instruments for a fixed amount of cash that is denominated in a foreign currency is a Financial Liability and not an equity instrument. The IFRIC discussed and questioned whether this was the appropriate and intended outcome of the standard, and consequently submitted a proposal to the International Accounting Standards Board (“IASB”) to amend IAS 32. As the IASB declined to make such an amendment to the standard, the IFRIC conclusion that instruments as described above should be classified as Financial Liabilities continues to stand.

As a consequence, on initial recognition the fair value of the warrants was required to be recognized as a Financial Liability at their fair value, reducing the Issued Capital recorded. At each reporting date the Financial Liability representing the warrants is required to be revalued to fair value with the movement in the fair value recorded in the Income Statement.

Note 16.

F - 18

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~11.~~	~~COMMITMENTS AND CONTINGENCIES~~

~~There has been no change in contingent liabilities since the last annual reporting date.~~

The Company’s former Chief Executive Officer, who also served as a director, has threatened to initiate a claim against the Company arising from his alleged inability to freely transfer shares underlying certain unexercised ADR options previously granted to him pursuant to the Company’s 2004 ADS Plan. The Company believes, based on the explicit terms of the 2004 ADS Plan and applicable law and regulations, his allegations to be without merit and it intends to vigorously defend any such claim if formally asserted. No actions or other legal proceedings in respect of this case have been filed.

Otherwise, the consolidated entity is not involved in any legal or arbitration proceedings nor, so far as Directors are aware, are such proceedings pending or threatened against the consolidated entity.

~~In respect of expenditure commitments, refer to Note 16.~~


~~12.~~	~~ISSUED CAPITAL~~

Years Ended June 30,

Notes

2009

2008

2007

(a) Issued Capital

Fully paid ordinary shares

12(b)

67,487,345

67,140,659

52,726,073

Options for fully paid ordinary shares

12(c)

2,701,644

2,701,644

1,262,339

70,188,989

69,842,303

53,988,412

			Years Ended June 30,
	Notes		2010		2009		2008
12. ISSUED CAPITAL

(a) Issued Capital		A.
Fully paid ordinary shares		12(b)		72,418,520		67,487,345		67,140,659
Options for fully paid ordinary shares		12(c)		2,701,644		2,701,644		2,701,644

				75,120,164		70,188,989		69,842,303

(b) Movements in Issued Shares

June 30,

2009

2008

2007

No.

$

No.

$

No.

$

Beginning of the year

201,800,240

67,140,659

151,517,978

52,726,073

128,144,260

46,274,127

Movement during the year

910,233

359,879

50,282,262

14,414,586

23,373,718

6,451,946

End of the year

202,710,473

67,487,345

201,800,240

67,140,659

151,517,978

52,726,073

	June 30,
	2010				2009				2008
	No.		$		No.		$		No.		$
Beginning of the year		202,710,473		67,487,345		201,800,240		67,140,659		151,517,978	52,726,073

Movement during the year		31,335,398		4,931,175		910,233		346,686		50,282,262	14,414,586

End of the year		234,045,871		72,418,520		202,710,473		67,487,345		201,800,240	67,140,659

Details of share issuances are as follows:

Date	Details	Notes	Number		Issue Price		$
July 23, 2008	Exercise of options – consultants			80,000		-	38,400
July 31, 2008	Exercise of options – consultants			80,000		-	35,200
August 27, 2008	Exercise of options – employees			18,939		-	7,576
September 3, 2008	Non cash share issue in consideration for services provided by consultants	(i)		31,250		0.42	13,125
October 15, 2008	Exercise of options – employees			21,952		-	8,781
October 15, 2008	Exercise of options – employees			28,947		-	6,658
November 13, 2008	Exercise of options – consultants			49,803		-	11,455
December 3, 2008	Non cash share issue in consideration for services provided by consultants	(i)		31,250		0.30	9,375
December 4, 2008	Exercise of options – consultants			400,000		-	158,000
March 3, 2009	Non cash share issue in consideration for services provided by consultants	(i)		31,250		0.18	5,625
March 3, 2009	Exercise of options – consultants			136,842		-	65,684
	Security issuance costs						(13,193	)
Year ended June 30, 2009				910,233			346,686
July 15, 2009	Exercise of options – employees			2,000		-	460
July 15, 2009	Exercise of options – employees			45,333		-	9,973
July 15, 2009	Exercise of options – consultants			80,000		-	15,200
July 15, 2009	Exercise of options – employees			53,333		-	11,733
September 2, 2009	Exercise of options – employees			54,500		-	11,990
October 8, 2009	Exercise of options – employees			30,000		-	6,600
October 8, 2009	Exercise of options – employees			75,232		-	16,551
November 9, 2009	Shares to investors as part of private placement			30,000,000		0.17	5,017,421
November 27, 2009	Shares to investors as part of private placement			750,000		0.17	125,436
March 2, 2010	Non cash share issue in consideration for services provided by consultants	(i)		165,000		0.15	24,750
March 2, 2010	Exercise of options – consultants			80,000		-	17,600
	Proposed Non cash share issue in consideration for services provided by consultants			-		0.32	17,517
	Security issuance costs						(344,056	)
Year ended June 30, 2010				31,335,398			4,931,175

F - 19

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

12. ISSUED CAPITAL (continued)


~~12.~~	~~ISSUED CAPITAL (continued)~~

~~Details of share issuances are as follows:~~

Date

Details

Notes

Number

Issue Price

$

October 30, 2007

Shares to investors as part of a private placement

29,778,699

0.24

7,047,624

December 24, 2007

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.27

8,437

December 24, 2007

Non cash share issue in consideration for services provided by consultants

(i)

250,000

0.30

75,000

December 24, 2007

Non cash share issue in consideration for services provided by consultants

(i)

22,135

0.25

5,534

February 26, 2008

Exercise of options – consultants

205,000

–

65,712

February 26, 2008

Exercise of options – employees

800,557

–

184,128

February 26, 2008

Non cash share issue in consideration for services provided by consultants

(i)

500,000

0.26

130,000

February 26, 2008

Non cash share issue in consideration for services provided by consultants

(i)

55,000

0.34625

19,044

February 26, 2008

Non cash share issue in consideration for services provided by consultants

(i)

9,115

0.25

2,279

March 20, 2008

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.50

15,625

March 20, 2008

Non cash share issue in consideration for services provided by consultants

(i)

55,000

0.34625

19,044

April 2, 2008

Exercise of options – employees

27,440

–

10,976

April 9, 2008

Exercise of options – employees

46,282

–

18,513

May 27, 2008

Shares to investors as part of a private placement

18,125,000

0.40

7,250,000

June 2, 2008

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.43

13,437

June 12, 2008

Exercise of options – consultants

275,000

–

113,895

June 25, 2008

Exercise of options – consultants

39,284

–

15,714

Security issuance costs

–

(580,376
)

Year ended
June 30, 2008

50,282,262

14,414,586

Date

Details

Notes

Number

Issue Price

$

July 23, 2008

Exercise of options – consultants

80,000

–

38,400

July 31, 2008

Exercise of options – consultants

80,000

–

35,200

August 27, 2008

Exercise of options – employees

18,939

–

7,576

September 3, 2008

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.42

13,125

October 15, 2008

Exercise of options – employees

21,952

–

8,781

October 15, 2008

Exercise of options – employees

28,947

–

6,658

November 13, 2008

Exercise of options – consultants

49,803

–

11,455

December 3, 2008

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.30

9,375

December 4, 2008

Exercise of options – consultants

400,000

–

158,000

March 3, 2009

Non cash share issue in consideration for services provided by consultants

(i)

31,250

0.18

5,625

March 3, 2009

Exercise of options – consultants

136,842

–

65,684

Security issuance costs

(13,193
)

Year ended
June 30, 2009

910,233

359,879

~~F - 20~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~12.~~	~~ISSUED CAPITAL (continued)~~

(i) Shares issued to consultants for services are recorded as non-cash compensation and are recognized at either the fair value of the services rendered, or if this cannot be reasonably estimated, the fair value of the underlying equity instruments issued. Shares issued to consultants have been valued as outlined below:

September 3, 2008, December ~~24, 2007, February 26,~~3, 2008, March ~~20, 2008~~3, 2009 and ~~June~~March 2, ~~2008~~

2010

The services provided by these consultants were documented in consultancy agreements which outlined remuneration in the form of an annual fee and share-based compensation in the form of shares. The equity-based compensation is not linked to any particular milestone or element of the services to be provided under the terms of the agreements.

Given the extended period of consultants involvement and associated milestones, the Company determined there were no comparable service examples against which to benchmark the value of the consultants’ services. Additionally, there was no distinction between the portion of the services which gave rise to the cash entitlements and the portion that gave rise to share entitlements. As the Company could not reliably estimate the fair value of the services received, the Company determined that it was appropriate to measure the services at the fair value of the underlying equity instruments issued.

June 30,

2009

2008

2007

Number of Options

$

Number of Options

$

Number of Options

$

Beginning of the year

14,279,133

2,701,644

4,352,893

1,262,339

–

–

Movement during the year

–

–

9,926,240

1,439,305

4,352,893

1,262,339

End of the year

14,279,133

2,701,644

14,279,133

2,701,644

4,352,893

1,262,339

	June 30,
	2010				2009			2008
	Number of Options			$	Number of Options		$	Number of Options		$
Beginning of the year		14,279,133		2,701,644		14,279,133	2,701,644		4,352,893	1,262,339

Movement during the year		(14,279,133	)	-		-	-		9,926,240	1,439,305

End of the year		-		2,701,644		14,279,133	2,701,644		14,279,133	2,701,644

Details of option grants are as follows:

Date

Details

Exercise Price

Number

Fair Value

$

October 30, 2007

Options to investors as part of a capital raising

$
0.37

3,628,598

0.15

544,290

October 30, 2007

Options to investors as part of a capital raising

$
0.43

3,628,598

0.14

508,004

October 30, 2007

Options to investors as part of a capital raising

$
0.37

1,188,323

0.15

178,248

October 30, 2007

Options to investors as part of a capital raising

$
0.43

1,188,323

0.14

166,365

October 30, 2007

Options to investors as part of a capital raising

$
0.37

146,199

0.15

21,930

October 30, 2007

Options to investors as part of a capital raising

$
0.43

146,199

0.14

20,468

Year ended
June 30, 2008

9,926,240

1,439,305

Year ended
June 30, 2009

–

–

Date

Details

Exercise Price

Number

Fair Value
$
Year ended June 30, 2009 - - - -
November 30, 2009 Options to investors expired unexercised $ 0.446 14,279,133 - -
Year ended June 30, 2010 14,279,133 -

(d) Terms and Conditions of Issued Capital

Ordinary shares

Ordinary shares have the right to receive dividends as declared and, in the event of a winding up of the Company, to participate in the proceeds from the sale of all surplus assets in proportion to the number of and amounts paid up on shares held. Ordinary shares entitle their holder to vote, either in person or by proxy, at a meeting of the Company’s shareholders.

Options

Option holders do not have the right to receive dividends and are not entitled to vote at a meeting of the Company’s shareholders. Options may be exercised at any time from the date they vest to the date of their expiration. Share options convert into ordinary shares on a one for one basis on the date they are exercised.

~~Ordinary shares~~
Ordinary shares have the right to receive dividends as declared and, in the event of a winding up of the Company, to participate in the proceeds from the sale of all surplus assets in proportion to the number of and amounts paid up on shares held. Ordinary shares entitle their holder to vote, either in person or by proxy, at a meeting of the Company’s shareholders.

~~Options~~
Option holders do not have the right to receive dividends and are not entitled to vote at a meeting of the Company’s shareholders. Options may be exercised at any time from the date they vest to the date of their expiration. Share options convert into ordinary shares on a one for one basis on the date they are exercised.

F - 21

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

12. ISSUED CAPITAL (continued)

(e) Shares Issued after Reporting Date
~~12.~~	~~ISSUED CAPITAL (continued)~~

~~(e) Shares Issued after Reporting Date~~

After reporting date the following equity issues occurred:

Date

Details

Notes

Number

Issue Price

$

July 15, 2009

Exercise of options – consultants

80,000

–

15,200

July 15, 2009

Exercise of options – employees

100,666

–

22,167

180,666

37,367

Date	Details	Notes	Number		Issue Price		$
July 19, 2010	Shares to investors as part of private placement			7,064,749		0.16	1,150,000
September 27, 2010	Non cash share issue in consideration for services provided by consultants			110,000		0.13	14,300
September 27, 2010	Exercise of options – employees			84,333		-	18,553
October 8, 2010	Exercise of options – employees			57,750		-	12,705
October 8, 2010	Exercise of options – employees			54,500		-	11,990
				7,371,332			1,207,548


~~13.~~	~~RESERVES~~

13.RESERVES

			Years Ended June 30,
	Notes		2010		2009		2008

(a)Share Based Payments
Options for fully paid ordinary shares		13(b)		6,613,582		5,158,335		4,098,743
Options for ADRs		13(c)		1,515,434		1,515,434		1,515,434
Warrants for ADRs		13(d)		453,563		453,563		453,563

				8,582,579		7,127,332		6,067,740

Years Ended June 30,

Notes

2009

2008

2007

(a) Share Based Payments

Options for fully paid ordinary shares

13(b)

5,158,335

4,098,743

2,137,824

Options for ADRs

13(c)

1,515,434

1,515,434

1,515,434

Warrants for ADRs

13(d)

453,563

453,563

453,563

7,127,332

6,067,740

4,106,821

The share-based payment reserve is used to recognize the fair value of options and warrants issued to directors, executives, employees and consultants but not exercised. Amounts are transferred out of the reserve and into issued capital when the options or warrants are exercised.

(b)Movements in Options for Fully Paid Ordinary Shares

Years Ended June 30,

2009

2008

2007

Number of Options

Comp.
Expense ($)

Number of Options

Comp.
Expense ($)

Number of Options

Comp.
Expense ($)

Beginning of the year

11,051,832

4,098,743

9,928,262

2,137,824

5,752,500

898,252

Issued during the year

3,099,818

760,913

5,617,133

1,949,511

5,908,762

1,153,422

Expired during the year

–

–

(1,100,000
)

–

(825,000
)

–

Forfeited during the year

–

–

(2,000,000
)

(143,133
)

(150,000
)

(2,950
)
Amortization of option expenses

–

–

–

563,479

–

195,839

Exercised during the year (Note 13(b))

(816,483
)

(217,754
)

(1,393,563
)

(408,938
)

(758,000
)

(106,739
)

End of the year

13,335,167

5,158,335

11,051,832

4,098,743

9,928,262

2,137,824

	Years Ended June 30,
	2010						2009						2008
	Number of Options			Comp. Expense ($)			Number of Options			Comp. Expense ($)			Number of Options			Comp. Expense ($)
Beginning of the year		13,335,167			5,158,335			11,051,832			4,098,743			9,928,262			2,137,824
Issued during the year		15,704,609			1,330,404			3,099,818			760,913			5,617,133			1,949,511
Expired during the year		(2,200,000	)		-			-			-			(1,100,000	)		-
Forfeited during the year		-			-			-			-			(2,000,000	)		(143,133	)
Amortization of option expenses		-			214,951			-			-			-			563,479
Exercised during the year (Note 13(b))		(420,398	)		(90,108	)		(816,483	)		(217,754	)		(1,393,563	)		(408,938	)

End of the year		26,419,378			6,613,582			13,335,167			5,158,335			11,051,832			4,098,743

Details of option grants are summarized as follows.

2008

~~2007~~

· On October 13, 2006, the Company granted options to purchase 133,000 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on July 31, 2008. The fair value of the options is A$0.42.

· On December 1, 2006, the Company granted options to purchase 3,200,000 ordinary shares to directors and an employee under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.80 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on July 31, 2009. The fair value of the options is A$0.38.

· On December 1, 2006, the Company granted options to purchase 312,500 ordinary shares to an employee under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.08.

· On April 16, 2007, the Company granted options to purchase 206,478 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.50 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on December 31, 2011. The fair value of the options is A$0.40.

· On April 16, 2007, the Company granted options to purchase 39,284 ordinary shares to an outside consultant under the 2004 ASX Plan (see Note 17) in consideration for services rendered to the Company. The options are exercisable once the ASX share price reaches A$0.50 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on December 31, 2011. The fair value of the options is A$0.40.

~~F - 22~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~13.~~	~~RESERVES (continued)~~

· On April 16, 2007, the Company granted options to purchase 1,000,000 ordinary shares to an employee under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.48.

· On April 16, 2007, the Company granted options to purchase 40,000 ordinary shares to an outside consultant under the 2004 ASX Plan (see Note 17) in consideration for services rendered to the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.36.

· On May 31, 2007, the Company granted options to purchase 312,500 ordinary shares to an employee under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.08.

· On June 12, 2007, the Company granted options to purchase 40,000 ordinary shares to an outside consultant under the 2004 ASX Plan (see Note 17) in consideration for services rendered to the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is $A0.38.

· On June 12, 2007, the Company granted options to purchase 375,000 ordinary shares to outside consultants under the 2004 ASX Plan (see Note 17) in consideration for services rendered to the Company. The options are exercisable once the ASX share price reaches A$0.50 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on December 31, 2011. The fair value of the options is $0.34.

· On June 19, 2007, the Company granted options to purchase 250,000 ordinary shares to an employee under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable once the ASX share price reaches A$0.40 for five consecutive trading days. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is $0.34.

~~2008~~

· On October 23, 2007, the Company granted options to purchase 431,992 ordinary shares to a consultant in recognition of services rendered to the Company. The options are exercisable at A$0.37 consideration and expire on October 31, 2010. The fair value of the options is A$0.15.

· On October 23, 2007, the Company granted options to purchase 431,992 ordinary shares to a consultant in recognition of services rendered to the Company. The options are exercisable at A$0.43 consideration and expire on November 30, 2010. The fair value of the options is A$0.14.

· On November 28, 2007, the Company granted options to purchase 400,000 ordinary shares to a consultant under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$0.285 consideration and expire on December 17, 2008. The fair value of the options is A$0.11.

· On February 26, 2008, the Company granted options to purchase 1,131,307 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.23.

· On February 26, 2008, the Company granted options to purchase 375,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.29.

F - 21

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

13. RESERVES (continued)

· On March 14, 2008, the Company granted options to purchase 2,400,000 ordinary shares to directors and the Company’s secretary under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options were held in escrow for one year from the date of grant. The options are exercisable at A$0.30 consideration and expire on October 31, 2010. The grant was approved by the Company’s shareholders at the 2007 Annual General Meeting. The fair value of the options is $A0.50.

· On March 20, 2008, the Company granted options to purchase 286,842 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.48.

· On April 2, 2008, the Company granted options to purchase 80,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.48.

· On May 15, 2008, the Company granted options to purchase 80,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.44.

~~F - 23~~

2009

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~13.~~	~~RESERVES (continued)~~

~~2009~~

· On October 17, 2008, the Company granted options to purchase 2,000,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on June 30, 2010. The fair value of the options is A$0.28.

· On June 16, 2009, the Company granted options to purchase 330,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.22.

· On June 16, 2009, the Company granted options to purchase 574,981 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.19.

· On June 16, 2009, the Company granted options to purchase 194,837 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.18.

2010

· On September 2, 2009, the Company granted options to purchase 80,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on October 31, 2010. The fair value of the options is A$0.22.

· On November 27, 2009, the Company granted options to purchase 10,000,000 ordinary shares to investors as part of a capital raising. The options are exercisable at A$0.30 consideration and expire on September 11, 2013. The fair value of the options is A$0.09.

· On November 27, 2009, the Company granted options to purchase 3,500,000 ordinary shares to consultants in recognition of services rendered to the Company. The options are exercisable at A$0.30 consideration and expire on September 23, 2012. The fair value of the options is A$0.08.

· On June 8, 2010, the Company granted options to purchase 645,853 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.14.

· On June 8, 2010, the Company granted options to purchase 60,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and expire on August 7, 2014. The fair value of the options is A$0.14.

· On June 8, 2010, the Company granted options to purchase 418,756 ordinary shares to employees under the 2004 ASX Plan (see Note 17) in recognition of future contributions to the growth and success of the Company. The options are exercisable at A$0.15 consideration and expire on March 31, 2014. The fair value of the options is A$0.13.

· On June 8, 2010, the Company granted options to purchase 1,000,000 ordinary shares to consultants under the 2004 ASX Plan (see Note 17) in recognition of services rendered to the Company. The options are exercisable at A$0.15 consideration and expire on March 31, 2014. The fair value of the options is A$0.11.

(c)Movements in Options for ADRs

Years Ended June 30,

2009

2008

2007

Number of Options

Comp.
Expense ($)

Number of Options

Comp.
Expense ($)

Number of Options

Comp.
Expense ($)

Beginning of the year

380,000

1,515,434

380,000

1,515,434

380,000

1,515,434

Issued during the year

–

–

–

–

–

–

End of the year

380,000

1,515,434

380,000

1,515,434

380,000

1,515,434

	Years Ended June 30,
	2010				2009				2008
	Number of Options		Comp. Expense ($)		Number of Options		Comp. Expense ($)		Number of Options		Comp. Expense ($)
Beginning of the year		380,000		1,515,434		380,000		1,515,434		380,000		1,515,434

End of the year		380,000		1,515,434		380,000		1,515,434		380,000		1,515,434

F - 22

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

13. RESERVES (continued)

(d)Movement in Warrants for ADRs

Years Ended June 30,

2009

2008

2007

Number of Warrants

Comp.
Expense ($)

Number of Warrants

Comp.
Expense ($)

Number of Warrants

Comp.
Expense ($)

Beginning of the year

320,000

453,563

320,000

453,563

320,000

453,563

Expired during the year

(320,000
)

–

–

–

–

–

End of the year

–

453,563

320,000

453,563

320,000

453,563

	Years Ended June 30,
	2010				2009					2008
	Number of Warrants		Comp. Expense ($)		Number of Warrants			Comp. Expense ($)		Number of Warrants		Comp. Expense ($)
Beginning of the year		-		453,563		320,000			453,563		320,000		453,563
Expired during the year		-		-		(320,000	)		-		-		-

End of the year		-		453,563		-			453,563		320,000		453,563

(e) Terms and Conditions of Reserves

Options and warrants

Option holders and warrant holders do not have the right to receive dividends and are not entitled to vote at a meeting of the Company’s shareholders. Options and warrants may be exercised at any time from the date they vest to the date of their expiration. Share options are exercisable into ordinary shares on a one for one basis on the date they are exercised. Options granted under the 2004 ADS Plan are exercisable into ADRs, being one option for one ADR, which equals ten ordinary shares, on the date they are exercised.

In Australia, there is not a set number of authorized shares, shares are not reserved for the exercise of options, and shares do not have a par value.

(f) Options and Warrants Issued after Reporting Date

Details of option issuances are as follows:

· On October 8, 2010, the Company granted options to purchase 200,000 ordinary shares to consultants under the 2004 ASX Plan in recognition of services rendered to the Company. The options are exercisable at A$nil consideration and ~~Warrants Issued after Reporting Date~~expire on August 7, 2014.

There have been no ~~options or~~ warrants granted after reporting date.

On September 8, 2009, the Company entered into a private placement agreement with one of its institutional shareholders in the United States, under which it agreed to grant the investor, subject to shareholder approval, options to purchase 10 million ordinary shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the private placement. If shareholder approval is not obtained for the option grant, the options will be granted at such time that shareholder approval is no longer required for the grant under the rules of the ASX.

	Years Ended June 30,
	2010			2009
14. ACCUMULATED DEFICIT DURING DEVELOPMENT STAGE

Balance at beginning of year		(73,566,505	)		(66,043,716	)
Net loss for the year		(4,906,922	)		(7,522,789	)

Balance at end of year		(78,473,427	)		(73,566,505	)

F - 24

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~14.~~	~~ACCUMULATED DEFICIT DURING DEVELOPMENT STAGE~~

	Years Ended June 30,
	2010			2009			2008
15.CASH FLOW INFORMATION

(a) Reconciliation of Net Loss to Net Cash Flows From Operations
Net loss		(4,906,922	)		(7,522,789	)		(13,560,678	)

Non-cash items
Depreciation of property and equipment		35,290			34,190			25,349
Non-cash issue of equity in consideration of operating expenses		730,478			1,305,471			4,097,562
Foreign exchange (gain) loss		2,017			(15,501	)		434,309
(Gain) loss on fair value of financial liabilities		-			(772,430	)		451,429

Changes in assets and liabilities
Decrease (increase) in trade and other receivables		(299	)		120,115			(24,142	)
Decrease (increase) in other current assets		(1,294,170	)		68,892			(85,786	)
(Decrease) increase in trade and other payables		640,275			(244,971	)		(812,496	)
Decrease (increase) in provision for employee entitlements		84,392			32,849			83,063

Net cash flows used in operating activities		(4,708,939	)		(6,994,174	)		(9,391,390	)

(b) Reconciliation of Cash and Cash Equivalents

Cash and cash equivalents balance comprises:
- cash and cash equivalents on hand		5,227,298			4,304,977			468,619
- term deposit/on call		-			-			10,750,416

Closing cash and cash equivalents balance		5,227,298			4,304,977			11,219,035

Years Ended June 30,

2009

2008

Balance at beginning of year

(66,043,716
)

(52,483,038
)
Net loss for the year

(7,522,789
)

(13,560,678
)

Balance at end of year

(73,566,505
)

(66,043,716
)


~~15.~~	~~CASH FLOW INFORMATION~~

Years Ended June 30,

2009

2008

2007

(a) Reconciliation of Net Loss to Net Cash Flows From Operations

Net loss

(7,522,789
)

(13,560,678
)

(11,142,320
)

Non-cash items

Depreciation of property and equipment

34,190

25,349

58,582

Non-cash issue of equity in consideration of operating expenses

1,305,471

4,097,562

1,579,132

Foreign exchange (gain) loss

(15,501
)

434,309

775,238

(Gain) loss on fair value of financial liabilities

(772,430
)

451,429

(607,691
)
Loss on sale of non-current asset

–

–

161

Changes in assets and liabilities

Decrease (increase) in trade and other receivables

120,115

(24,142
)

97,662

Decrease (increase) in other current assets

68,892

(85,786
)

(57,707
)
(Decrease) increase in trade and other payables

(244,971
)

(812,496
)

123,251

Decrease (increase) in provision for employee entitlements

32,849

83,063

(26,058
)

Net cash flows used in operating activities

(6,994,174
)

(9,391,390
)

(9,199,750
)

(b) Reconciliation of Cash and Cash Equivalents

Cash and cash equivalents balance comprises:

- cash and cash equivalents on hand

4,304,977

468,619

456,193

- term deposit/on call

–

10,750,416

6,953,063

- commercial bill

–

–

–

Closing cash and cash equivalents balance

4,304,977

11,219,035

7,409,256

During the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, the Company issued shares and granted options in connection with non-cash transactions. See Notes 12(b) and 13(b).

~~F - 25~~

~~PRANA BIOTECHNOLOGY LIMITED~~16.EXPENDITURE COMMITMENTS

~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~16.~~	~~EXPENDITURE COMMITMENTS~~

The Company has a non-cancelable operating lease contracted for but not capitalized in the financial statements. The Company has commitments under this contract within one year of ~~$110,411~~A$114,152 and between one year and five years of ~~$40,521.~~A$38,520. The property lease is a non-cancellable lease with ~~an 18~~a 12 month term, with rent payable monthly in advance. The property lease commenced ~~May 1, 2008 and is due to expire October 31, 2009. Commencing~~ November 1, 2009 and commencing November 1, 2010, the lease ~~has been~~was renewed for a further term of ~~12 months. An option exists to renew the lease at the end of October 31, 2010 for a further~~ 12 months. Within the lease agreement there is a contingent rental provision which allows the lease payments to be increased by 3.50% of the rental payments on an annual basis.

Details in relation to commitments under employee service agreements with Directors and Key Management Personnel are outlined in Note 20.

The Company has commitments under research and development contracts within one year of ~~$449,677~~A$2,151,895 and ~~great~~greater than one year but less than three years of ~~$43,028, last~~A$86,335. For the fiscal year ended June 30, 2009, commitments under research and development contracts within one year were ~~$894,566.~~A$485,861 and greater than one year but less than three years were A$43,028. There ~~are~~were no ~~researches~~research and development contract commitments after one year for the ~~years~~year ended June 30, 2008, commitments under research and ~~2007.~~


~~17.~~	~~SHARE BASED PAYMENTS~~

development contracts within one year for the year ended June 30, 2008 were A$894,566.

F - 24

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

17.SHARE BASED PAYMENTS

(a)Employee and Consultant Plans

At the Annual General Meeting held on November 17, 2004, the shareholders approved the establishment of employee and consultant plans designed to reward directors, employees and/or consultants for their contributions to the Company. The plans are to be used as a method of retaining key personnel for the growth and development of the Company. Due to Prana’s U.S. presence, a U.S. plan (the 2004 ADS Plan) and an Australian plan (the 2004 ASX Plan) were developed. At June 30, ~~2009,~~2010, equity had been issued to one previous Director under the 2004 ADS Plan and five Directors, three key management personnel, 16 employees and 16 consultants under the 2004 ASX Plan. At June 30, 2009, equity had been issued to one previous Director under the 2004 ADS Plan and five Directors, three key management pe rsonnel, 16 employees and 16 consultants under the 2004 ASX Plan. At June 30, 2008, equity had been issued to one former and four current Directors, three key management personnel, 16 employees and 10 consultants ~~under the 2004 ASX Plan. At June 30, 2007, equity had been issued to one director under the 2004 ADS Plan and five directors, 10 consultants and 14 employees~~ under the 2004 ASX Plan. At the 2004 Annual General Meeting shareholders authorized the Company to issue in the aggregate up to 12 million ordinary shares under the two plans. This was increased to 22 million ordinary shares at the 2005 Annual General Meeting. This was further ~~increase~~increased to 30 million ordinary shares at the 2007 Annual General Meeting, 45 million ordinary shares at the 2008 Annual General Meeting and 60 million ordinary shares at the 2009 Annual General Meeting. The Share Plan Committee, a sub-committee of the Remuneration Committee administers the two plans and is able to change the terms of the equity issued under them from the default ~~terms.~~

terms.

Under the 2004 ADS Plan, the exercise price must equal or exceed the fair value of the ADS on the date the options are awarded. The option expiration date cannot exceed ten years from the date the options were awarded. The default vesting conditions are 25% per year on the date the options were awarded.

Under the 2004 ASX Plan, the exercise price must be equal or be less than the market value of the ordinary shares on ASX on the date of grant. The option expiration date cannot exceed ten years from the date the options were granted. The default vesting conditions are 25% per year on the date the options were granted.

Information with respect to the number of options granted under the 2004 ASX Plan as follows:

Years Ended June 30,

2009

2008

2007

Number of Options

Weighted Average Exercise Price ($)

Number of Options

Weighted Average Exercise Price ($)

Number of Options

Weighted Average Exercise Price ($)

Beginning of the year

10,187,848

0.08

9,928,262

0.06

4,927,500

0.11

Issued during the year

3,099,818

0.32

4,753,149

0.38

5,908,762

0.36

Exercised during the year

(816,483
)
0.27

(1,393,563
)
0.62

(758,000
)
0.38

Expired during the year

–

Nil

(1,100,000
)
Nil

–

Nil

Forfeited during the year

–

Nil

(2,000,000
)
Nil

(150,000
)
Nil

Outstanding at year end

12,471,183

0.14

10,187,848

0.08

9,928,262

0.06

Exercisable at year end

7,398,846

0.14

5,610,348

0.15

2,140,000

0.26

~~F - 26~~

~~PRANA BIOTECHNOLOGY LIMITED~~

~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~17.~~	~~SHARE BASED PAYMENTS (continued)~~

	Years Ended June 30,
	2010					2009					2008
	Number of Options			Weighted Average Exercise Price ($)		Number of Options			Weighted Average Exercise Price ($)		Number of Options			Weighted Average Exercise Price ($)
Beginning of the year		12,471,183			0.14		10,187,848			0.08		9,928,262			0.06
Issued during the year		2,204,609			0.10		3,099,818			0.32		4,753,149			0.38
Exercised during the year		(420,398	)	Nil			(816,483	)		0.14		(1,393,563	)		0.62
Expired during the year		(2,200,000	)	Nil			-		Nil			(1,100,000	)	Nil
Forfeited during the year		-		Nil			-		Nil			(2,000,000	)	Nil

Outstanding at year end		12,055,394			0.16		12,471,183			0.14		10,187,848			0.08

Exercisable at year end		8,477,204			0.23		7,398,846			0.23		5,610,348			0.15

The range of exercise prices of options outstanding at period end is nil to A$0.50. These options have a weighted average remaining contractual life of ~~one and a half~~1.31 years. The weighted average fair value of options granted during the period was determined in accordance with Note 1(p) as A$0.12, A$0.25 ~~A$0.38~~ and A$~~0.36~~0.38 for the years ended June 30, 2010, 2009 ~~2008~~ and ~~2007,~~2008, respectively. The weighted average assumptions in calculating fair value were as follows:


·	~~risk-free interest rate of 4.12% for 2009 and 6.63% for 2008;~~
·	~~no dividends;~~
·	~~expected volatility of 155% for 2009 and 234.20% for 2008; and~~
·	~~expected life of 1.85 years for 2009 and two years for 2008.~~

risk-free interest rate of 5.13% for 2010 and 4.12% for 2009;

· no dividends;

· expected volatility of 120% for 2010 and 155% for 2009; and

· expected life of 3.98 years for 2010 and 1.85 for 2009.

Risk free interest rate– This is the government bond rate (having a term that most closely resembles the expected life of the option) in effect at the grant date. The Australian government bond rate has been used for options which are exercisable for fully paid ordinary shares and the U.S. government bond rate has been used for options which are exercisable for ADRs.

Dividend yield– Prana has never declared or paid dividends on its ordinary shares and does not anticipate paying any dividends in the foreseeable future.

Expected volatility– Prana estimates expected volatility based on historical volatility over the estimated life of the option and other factors.

F - 25

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

17. SHARE BASED PAYMENTS (continued)

Expected life– This is the period of time that the options granted are expected to remain outstanding. This estimate is based primarily on historical trend of option holders to exercise their option near the date of expiry. As a result the expected life is considered to equal the period from grant date to expiry date.

~~Options existing in 2004 and 2006 to purchase 825,000 ordinary shares granted to a consultant outside of the 2004 ASX Plan expired in the year ended June 30, 2007.~~

Information with respect to the number of shares issued under the 2004 ASX Plan as follows:

Years Ended June 30,

2009

2008

2007

Number of Shares

Number of Shares

Number of Shares

Beginning of the year

4,166,252

1,787,689

428,439

Issued during the year¹

910,233

2,378,563

1,359,250

End of the financial year

5,076,485

4,166,252

1,787,689

	Years Ended June 30,
	2010		2009		2008
	Number of Shares		Number of Shares		Number of Shares
Beginning of the year		5,076,485		4,166,252		1,787,689
Issued during the year 1		585,398		910,233		2,378,563

End of the financial year		5,661,883		5,076,485		4,166,252

¹In the years ended June 30, 2010, 2009 and 2008 this includes options to purchase 420,398; 816,483 and 1,393,563 ordinary shares, respectively granted under the 2004 ASX Plan that were exercised.

Information with respect to the number of options granted under the 2004 ADS Option Plan as follows:

Years Ended June 30,

2009

2008

2007

Number of Options

Weighted Average Exercise Price ($)

Number of Options

Weighted Average Exercise Price ($)

Number of Options

Weighted Average Exercise Price ($)

Beginning of the year

380,000

US$5.00 (A$6.22)

380,000

US$5.00 (A$5.21)

380,000

US$5.00 (A$5.89)

Issued during the year¹

–

–

–

–

–

–

Outstanding at year end

380,000

US$5.00 (A$6.22)

380,000

US$5.00 (A$5.21)

US$5.00 (A$5.89)

Exercisable at year end¹

380,000

US$5.00 (A$6.22)

380,000

US$5.00 (A$5.21)

US$5.00 (A$5.89)

	Years Ended June 30,
	2010					2009					2008
	Number of Options		Weighted Average Exercise Price ($)			Number of Options		Weighted Average Exercise Price ($)			Number of Options		Weighted Average Exercise Price ($)
Beginning of the year		380,000	$	US5.00 (A$5.84	)		380,000	$	US5.00 (A$6.22	)		380,000	$	US5.00 (A$5.21	)
Issued during the year 1		-		-			-		-			-		-

Outstanding at year end		380,000	$	US5.00 (A$5.84	)		380,000	$	US5.00 (A$6.22	)		380,000	$	US5.00 (A$5.21	)

Exercisable at year end 1		380,000	$	US5.00 (A$5.84	)		380,000	$	US5.00 (A$6.22	)		380,000	$	US5.00 (A$5.21	)

¹ These options are exercisable into ADRs (one option granted under the 2004 ADS Plan is exercisable for one ADR = ten ASX shares)

The benefit to executives, employees, director and consultants is recognized in the financial statements over the period in which the services are provided. Refer to Notes 12, 13 and 20 for further information.

Options granted that have not been exercised carry no dividend rights or right to vote.

~~F - 27~~

~~PRANA BIOTECHNOLOGY LIMITED~~18.SUBSEQUENT EVENTS
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~18.~~	~~SUBSEQUENT EVENTS~~

On September 8, 2009, the Company entered into a private placement agreement with one of its institutional shareholders in the United States, under which it will raise an aggregate A$6.0 million before costs (approximately A$5.7 million net of costs) in a private placement of itsAugust 17, 2010 Prana Biotechnology received shareholder approval to place up to 225,000,000 new fully paid ordinary shares ~~to such investor. Of such amount, A$3.0 million was paid~~having an issue price at ~~the closing~~least eighty percent (80%) of the private placement on September 11, 2009 and an additional A$3.0 million will be paid on or before September 30, 2009. The private placement was for 30 million ordinary shares (equivalent to three million ADRs) at aaverage market price of ~~A$0.20 per share (A$2.0 per ADR). The Company also agreed to grant~~ the ~~investor, subject to shareholder approval, options to purchase 10 million ordinary~~Company’s shares (equivalent to one million ADRs) at an exercise price of A$0.30 per share (A$3.0 per ADR) that will expire four years after the date of the issuance of the shares in the private placement. If shareholder approval is not obtained for the ~~option grant,~~five (5) trading days prior to the ~~options will be granted at such time that shareholder approval is no longer required for the grant under the rules~~issue of ~~the ASX. The proceeds from the private placement will be used to support the Company’s research and development programs and to fund its working capital requirements.~~

those shares.

Other than as described above, there have been no significant changes in the operation or financial condition of the Company since June 30, ~~2009.~~


~~19.~~	~~LOSS PER SHARE~~

2010.

Years Ended June 30,

2009

2008

2007

Basic and diluted loss per share

(0.04
)

(0.08
)

(0.08
)

Weighted average number of ordinary shares on issue used in the calculation of basic and diluted loss per share

202,357,885

174,714,146

140,754,495

F - 26

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

	Years Ended June 30,
	2010			2009			2008
19.LOSS PER SHARE
Basic and diluted loss per share		(0.02	)		(0.04	)		(0.08	)

Weighted average number of ordinary shares on issue used in the calculation of basic and diluted loss per share		227,527,388			202,357,885			174,714,146

The options and warrants in place do not have the effect of diluting the loss per share.

20. KEY MANAGEMENT PERSONNEL COMPENSATION

(a) The Directors of Prana during the year:
~~20.~~								~~KEY MANAGEMENT PERSONNEL COMPENSATION~~

~~(a) The Directors of Prana during the year:~~


Geoffrey Kempler	Executive Chairman Chief Executive Officer
Brian Meltzer	Non-Executive Director
George Mihaly	Non-Executive Director
Peter Marks	Non-Executive Director
Paul Marks	Non-Executive Director (appointed 14 January 2010)

(b) The Key Management Personnel of the Company during the year:

Dianne Angus	Chief Operating Officer
Richard Revelins	Company Secretary
	Chief Financial Officer

Remuneration of all key management personnel of the Company is determined by the Board following recommendation by the Remuneration Committee.

The Company is committed to remunerating senior executives in a manner that is market competitive and consistent with ‘best practice’ including the interests of shareholders. Remuneration packages are based on fixed and variable components, determined by the executive’s position, experience and performance, and may be satisfied via cash or equity.

Non-executive Directors are remunerated out of the aggregate amount approved by shareholders and at a level that is consistent with industry standards. Non-executive Directors do not receive performance based bonuses and prior shareholder approval is required to participate in any issuance of equity. No retirement benefits are payable other than statutory superannuation, if applicable.

The ~~Company’s~~Company's remuneration policy is not directly based on the ~~Company’s~~Company's performance, rather on industry practice.

The ~~Company’s~~Company's primary focus is research activities with a long term objective of developing and commercialising its research and development results.

The Company envisages its performance in terms of earnings will remain negative whilst the Company continues in the research and/or trial phase. Shareholder wealth reflects this speculative and volatile market sector. This pattern is indicative of the ~~Company’s~~Company's performance over the past four years.

~~F - 28~~

~~PRANA BIOTECHNOLOGY LIMITED~~
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~20.~~	~~KEY MANAGEMENT PERSONNEL COMPENSATION (continued)~~

The purpose of a performance bonus is to reward individual performance in line with Company objectives. Consequently, performance based remuneration is paid to an individual where the ~~individual’s~~individual's performance clearly contributes to a successful outcome for the Company. This is regularly measured in respect of performance against key performance indicators ~~(“KPI’s”~~("KPI's").

The Company uses a variety of ~~KPI’s~~KPI's to determine achievement, depending on the role of the executive being assessed. These include:


·	~~successful contract negotiations;~~
·	~~Company share price reaching a targeted rate on the ASX or applicable market over a period of time; or~~
·	~~achievement of research project milestones within scheduled time and/or budget.~~

· successful contract negotiations;

· Company share price reaching a targeted rate on the ASX or applicable market over a period of time; or

· achievement of research project milestones within scheduled time and/or budget.

Short Term Benefits

Post-Employment

Equity

2009

Directors’ remuneration

Base Fee
$

Bonus
$

Superannuation
Contribution
$

Options
$

Total
$

Geoffrey Kempler^{1,2 & 4}

299,904

–

29,992

240,413

570,309

Brian Meltzer^1&3

68,807

–

6,193

72,124

147,124

George Mihaly^1&3

62,500

–

–

72,124

134,624

Peter Marks^1&3

45,833

–

–

56,635

102,468

477,044

–

36,185

441,296

954,525

F - 27

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

^{20. KEY MANAGEMENT PERSONNEL COMPENSATION (continued)}

	Short Term Benefits				Post-Employment		Equity
2010 Directors’ remuneration	Base Fee $		Bonus $		Superannuation Contribution $		Options $		Total $
Geoffrey Kempler 1 & 2		366,729		-		36,673		92,724		496,126
Brian Meltzer 1		82,569		-		7,431		27,817		117,817
George Mihaly 1		75,000		-		-		27,817		102,817
Peter Marks 1		55,000		-		-		12,328		67,328
Paul Marks		16,820		-		1,514		-		18,334
		596,118		-		45,618		160,686		802,422

1This includes equity issued as per the Annual General Meetings held on 30 November 2005 and 17 November 2004. As per Australian accounting standards the options issued to Directors were valued at grant date and are being expensed over the anticipated life of the options. As a result, the value does not reflect the current market price of the Company's shares. The Board believes that if the options issued in 2004 and 2006 were valued in today's market, they would have minimal intrinsic value given the market condition attached to the options that the share price must reach A$1.00 for five consecutive trading days.

2 In accordance with his employment contract, long service leave has been accrued for Mr. Kempler. At June 30, 2010, A$27,134 had been accrued to date. No amounts have been paid in the June 30, 2010 financial year.

	Short Term Benefits				Post-Employment		Equity
2009 Directors’ remuneration	Base Fee $		Bonus $		Superannuation Contribution $		Options $		Total $
Geoffrey Kempler 1,2 & 4		299,904		-		29,992		240,413		570,309
Brian Meltzer 1&3		68,807		-		6,193		72,124		147,124
George Mihaly 1&3		62,500		-		-		72,124		134,624
Peter Marks 1&3		45,833		-		-		56,635		102,468
		477,044		-		36,185		441,296		954,525

1 This includes equity issued as per the Annual General Meetings held on November 30, 2006, November 30, 2005 and November 30, 2004. As per Australian accounting standards, the options granted to Directors were valued at grant date and are being expensed over the anticipated life of the options. As a result, the value does not reflect the current market price of the Company’s shares. The Board believes that if the options issued in 2005 and 2006 were valued in today’s market, they would have minimal intrinsic value given the market condition attached to the options that the share price must reach ~~$1.00~~A$1.00 and ~~$0.80,~~A$0.80, respectively, for five consecutive trading days.

²On March 1, 2009, Mr. Kempler voluntarily elected to reduce his salary, the total decrease was ~~$73,484.~~A$73,484. This is a decrease to ~~$329,896~~A$329,896 from ~~$403,380.~~A$403,380.

³Effective from March 1, 2009, the Non-Executive Directors voluntarily elected to reduce their salaries by 50% for the period March 1, 2009 to June 30, 2009; this represents a decrease of:


~~Mr. Brian Meltzer~~	~~$15,000~~
~~Dr. George Mihaly~~	~~$12,500~~
~~Mr. Peter Marks~~	~~$ 9,167~~

Mr. Brian Meltzer A$ 15,000

Dr. George Mihaly A$ 12,500

Mr. Peter Marks A$ 9,167

⁴In accordance with his employment contract, long service leave has been accrued for Mr. Kempler. At June 30, 2009, ~~$40,050~~A$40,050 had been accrued to date. No amounts have been paid in the June 30, 2009 financial year.

F - 29

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

20.KEY MANAGEMENT PERSONNEL COMPENSATION (continued)

~~20.~~

	Short Term Benefits				Post-Employment		Equity
2010 Executives’ Remuneration	Base Fee $		Bonus $		Superannuation Contribution $		Options $		Total $
Richard Revelins1		80,000		-		-		-		80,000
Dianne Angus 2,3,4 & 5		296,153		50,000		31,154		52,662		429,969

		376,153		50,000		31,154		52,662		509,969

~~KEY MANAGEMENT PERSONNEL COMPENSATION (continued)~~

Short Term Benefits

Post-Employment

Equity

2008

Directors’ Remuneration

Base Fee
$

Bonus
$

Superannuation
Contribution
$

Options
$

Total
$

Geoffrey Kempler^{1,2, 3, 4}

351,273

50,000

35,127

741,072

1,177,472

Brian Meltzer¹

91,743

–

8,257

247,321

347,321

George Mihaly¹

75,000

–

–

247,321

322,321

Peter Marks¹

75,000

–

–

231,790

306,790

593,016

50,000

43,384

1,467,504

2,153,904

¹This includes equity issued as per the Annual General Meetings held on ~~December 20, 2007,~~30 November ~~30, 2006, November 30,~~ 2005 and 17 November ~~30,~~ 2004. As per ~~IFRS~~Australian accounting standards the options ~~with market conditions~~ issued to Directors were valued at grant date and are being expensed over the anticipated life of the options. As a result, the value does not reflect the current market price of the ~~Company’s~~Company's shares. The Board believes that if the options issued in 2004 ~~2005~~ and 2006 were valued in ~~today’s~~today's market, they would have minimal intrinsic value given the market condition attached to the options that the share price must reach ~~$1.00 and $0.80 respectively~~A$1.00 for five consecutive trading days.

2 This includes equity issued to Ms Angus in the 2009 financial year. As per Australian accounting standards the options issued to Ms Angus were valued at grant date and are being expensed over the anticipated life of the options. See the ~~2007~~2009 remuneration table below for valuations of the options ~~approved at~~issued to Ms Angus during the ~~November 30, 2006, November 30, 2005 and November 30, 2004 Annual General Meetings.~~2009 year.

3 Ms Angus received unlisted options during the year. The ~~value of the options approved at the December 20, 2007 Annual General Meeting~~option prices were calculated using the Black-Scholes Model applying the following inputs:

Grant Date: 27 May 2010	Volatility: 88%
~~Grant Date: December 20, 2007~~ Exercise Price: A$0.15	Risk-free Interest Rate: 4.75%
~~Exercise~~Stock Price: ~~$0.30~~ A$0.15	Dividend Yield: 0%
~~Stock Price: $0.50~~
Years to Expiry: ~~2.9~~ 3.85
~~Volatility: 387%~~
~~Risk-free Interest Rate: 6.82%~~
~~Dividend Yield: 0%~~
Option Price: ~~$0.50~~ $0.10

²~~On June 5, 2008, Mr. Kempler~~4 Ms Angus received a salary increase during the year to ~~$298,964~~A$315,637 plus ~~10% superannuation for Executive Chairman duties and $67,765 plus 10% superannuation for Chief Executive Officer duties. Total package of $366,729 plus 10%~~9% superannuation, which ~~is effective on July 1, 2008. This~~ is an increase from ~~$351,273~~A$292,256 plus ~~10%~~9% superannuation. During the year Ms Angus received a cash bonus of A$50,000 in accordance with her employment contract in relation to her performance during 2009 and continued commitment to the Company.

³5 In accordance with ~~his~~her employment contract, long service leave has been accrued for ~~Mr. Kempler.~~Ms Dianne Angus. At June 30, ~~2008 $12,573~~2010, A$49,517 had been accrued to date. No amounts have been paid in the June 30, ~~2008~~2010 financial year.

	Short Term Benefits				Post-Employment		Equity
2009 Executives’ Remuneration	Base Fee $		Bonus $		Superannuation Contribution $		Options $		Total $
Richard Revelins1&2		66,667		-		-		44,307		110,974
Dianne Angus 3 & 4		292,256		-		26,303		11,718		330,277

		358,923		-		26,303		56,025		441,251

⁴~~During the year Mr. Kempler received a cash bonus of $50,000 in accordance with his employment contract in relation to a successful capital raising.~~1

Short Term Benefits

Post-Employment

Equity

2009

Executives’ Remuneration

Base Fee
$

Bonus
$

Superannuation
Contribution
$

Options
$

Total
$

Richard Revelins^1&2

66,667

–

–

44,307

110,974

Dianne Angus^{3 & 4}

292,256

–

26,303

11,718

330,277

358,923

–

26,303

56,025

441,251

¹This includes equity issued as per the Annual General Meetings held on November 30, 2006, November 30, 2005 and November 30, 2004. As per Australian accounting standards the options granted to Directors were valued at grant date and are being expensed over the anticipated life of the options. As a result, the value does not reflect the current market price of the Company’s shares. The Board believes that if the options granted in 2005 and 2006 were valued in today’s market, they would have minimal intrinsic value given the market condition attached to the options that the share price must reach ~~$1.00~~A$1.00 and ~~$0.80~~A$0.80 respectively for five consecutive trading days.

²On March 1, 2009, Mr. Revelins voluntarily elected to reduce his salary by 50% for the period March 1, 2009 to June 30, 2009; this represents a decrease of ~~$13,333.~~A$13,333.

~~F - 30~~

~~PRANA BIOTECHNOLOGY LIMITED~~3
~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~20.~~	~~KEY MANAGEMENT PERSONNEL COMPENSATION (continued)~~

³Ms Angus received unlisted options during the year. The option prices were calculated using the Barrier Pricing Model applying the following inputs:


Grant Date: 26 May 2009	Barrier: ~~$0.00~~ A$0.00
Pricing Model: American	Days to Expiry: 1,898
Option Type: Call	Volatility: 52%
Barrier Type: Up and In	Risk-free Interest Rate: 3.56%
Strike Price: ~~$0.00~~ A$0.00	Expected Dividends: ~~$0.00~~ A$0.00
Spot Price: ~~$0.22~~ A$0.22	Option Price: ~~$0.18~~ A$0.18

⁴In accordance with her employment contract, long service leave has been accrued for Ms Dianne Angus. At June 30, 2009, ~~$17,449~~A$17,449 had been accrued to date. No amounts have been paid in the June 30, 2009 financial year.

Short Term Benefits

Post-Employment

Equity

2008

Executives’ Remuneration

Base Fee
$

Bonus
$

Superannuation
Contribution
$

Options
$

Total
$

Richard Revelins

80,000

–

–

219,428

299,428

Dianne Angus^{1,2 & 3}

280,191

–

25,217

115,000

420,408

360,191

–

25,217

334,428

719,836

¹~~Ms Angus received a salary increase during the year to $292,256 plus 9% superannuation, which is an increase from 268,425 plus 9% superannuation.~~

²~~Ms Angus received unlisted options during the year. The option prices were calculated using the Barrier Pricing Model applying the following inputs:~~


~~Grant Date: December 5, 2007~~	~~Barrier: $0.00~~
~~Pricing Model: American~~	~~Days to Expiry: 1,059~~
~~Option Type: Call~~	~~Volatility: 79%~~
~~Barrier Type: Up and In~~	~~Risk-free Interest Rate: 6.46%~~
~~Strike Price: $0.00~~	~~Expected Dividends: $0.00~~
~~Spot Price: $0.23~~	~~Option Price: $0.23~~

³In accordance with her employment contract, long service leave has been accrued for Ms Angus. At June 30, 2008 $29,895 had been accrued to date. No amounts have been paid in the June 30, 2008 financial year.

F - 31

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

20.KEY MANAGEMENT PERSONNEL COMPENSATION (continued)


~~20.~~	~~KEY MANAGEMENT PERSONNEL COMPENSATION (continued)~~

The following Director was under contract at June 30, ~~2009:~~

2010:

Directors	Duration	Notice Requirements		Termination						Bonus
~~Directors~~		~~Duration~~		~~Notice Requirements~~		~~Termination~~			~~Bonus~~


Mr. Geoffrey Kempler		Until termination by either party Signed September 21, 2007		For Good Reason Mr. Kempler may terminate with 30 days notice Or Without Cause the Company may terminate with 90 days notice	●	·	Pay Mr. Kempler within ninety (90) days of the termination date $1,000,000 provided the Company has sufficient capital requirements to fulfill this clause	●	·	Bonus of $50,000 following a capital raising of at least A$7m (before costs) prior to September 30, 2007.
					●
						·	Accrued entitlements including all unreimbursed business expenses	●	·	Bonus of $25,000 following a further capital raising of at least A$12m (before costs) anytime in the 2008 financial year.
			●
						·	Accelerate the vesting of any unvested options	·	·	Bonus of $25,000 for attaining a share price above $0.60 for at least four consecutive trading days by June 30, 2008.

				Without Good Reason Mr. Kempler may terminate with 90 days notice Or With Cause the Company may terminate with 30 days notice	●	·	Bonus pro-rate only if termination occurs in 1^st year		Bonus of $50,000 for implementation of the following:
						●
										·	Completion of clinical trial recruitment by September 30, 2007 - $10K bonus
						●
									·	Completion of signed Statistical Analysis Report by February 29, 2008 - $10K bonus
				●
									·	Regular meetings (minimum twice yearly) of the full Integrated Advisory Board - $6k bonus
					●
									·	Review and provide written proposal to the board of ~~Prana’s~~Prana's intellectual property portfolio to determine other value add opportunities for license, merger and acquisition or divestment by December 31, 2007 - $14K bonus
					●
									·	Develop Prana staff retention strategy and action plan by October 31, 2007 and implement by December 31, 2007 - $10K bonus
					●
									·	As per Remuneration Committee Meeting, June 5, 2008, bonus of $100,000 for outstanding performance including the overseeing of a $A 7.3 million capital raising without incurring the over $400K of fees usually associated with this.

F - 32

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

20.KEY MANAGEMENT PERSONNEL COMPENSATION (continued)


~~20.~~	~~KEY MANAGEMENT PERSONNEL COMPENSATION (continued)~~

The following Senior Executives were under contract during the financial year ended June 30, ~~2009:~~

2010:

Key Management Personnel	Duration	Notice Requirements		Termination					Bonus
~~Key Management Personnel~~		~~Duration~~		~~Notice Requirements~~		~~Termination~~		~~Bonus~~


Ms Dianne Angus		Until termination by either party Signed October 2, 2006 Letter Agreement signed June 12, 2007		For Good Reason Ms Angus may terminate with 30 days notice Or Without Cause the Company may terminate with 120 days notice	●	·	Pay remuneration entitlements one year from the time of termination (less any payout made for the notice period). The Company can elect to pay such sum as cash, equity in the Company or as a combination of both cash and equity
			●
						·	Accrued entitlements including all unreimbursed business expenses
			●
						·	Accelerate the vesting of any unvested options

				Without Good Reason Ms Angus may terminate with 120 days notice Or With Cause the Company may terminate without notice	●	·	Permitted to keep and/or exercise options that have vested at the time of termination
			●
						·	Accrued entitlements including all unreimbursed business expenses


~~21.~~	~~AUDITORS’ REMUNERATION~~

Years Ended June 30,

2009

2008

2007

- audit fees: current year

120,951

219,920

240,800

- tax fees

–

–

–

- other fees

–

–

–

120,951

219,920

240,800

	Years Ended June 30,
	2010		2009		2008
21.AUDITORS’ REMUNERATION

- audit fees: current year		140,672		120,951		219,920
- audit fees: internal control		45,000		-		-
- audit fees: SEC reporting		26,637		-		-

		212,309		120,951		219,920

PricewaterhouseCoopers was appointed as the Company’s principal independent registered public accounting firm on November 30, 2006. No non-audit services were provided by PricewaterhouseCoopers during the ~~2008~~2009 and ~~2009~~2010 fiscal years.

Deloitte Touche Tohmatsu served as the Company’s principal independent registered public accounting firm until November 30, 2006. The fees billed by Deloitte Touche Tohmatsu, as well as the other member firms of Deloitte Touche Tohmatsu and their respective affiliates, for the 2009 and 2008 fiscal years were A$9,267 and A$71,773, respectively, for audit-related services provided in connection with a Securities and Exchange Commission review of the Company’s annual report on Form 20-F for the fiscal year ended June 30, 2006 and an amendment to its annual report on Form 20-F for such period.

F - 33

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~22.~~	~~RELATED PARTY TRANSACTIONS~~

22. RELATED PARTY TRANSACTIONS

a. Equity Interests in Subsidiaries

Prana owns 100% of its subsidiaries, Prana Biotechnology Inc. and Prana Biotechnology UK Ltd.

b. Key Management Personnel Remuneration

Details of key management personnel remuneration is disclosed in Note 20 to the financial statements.

c. Key Management Personnel Equity Holdings

Fully Paid Ordinary Shares of the Company	Balance July 1, 2009		Received as Remuneration		Received on Exercise of Options		Net Change Other1		Balance June 30, 2010
	No.		No.		No.		No.		No.
Geoffrey Kempler		17,055,000		-		-		-		17,055,000
Brian Meltzer		326,666		-		-		-		326,666
George Mihaly		226,666		-		-		-		226,666
Peter Marks		43,111		-		-		-		43,111
Paul Marks2		8,589,361		-		-		-		8,589,361
Richard Revelins		20,308		-		-		-		20,308
Dianne Angus		250,000		-		-		-		250,000

		26,511,112		-		-		-		26,511,112

Fully Paid Ordinary Shares of the Company	Balance July 1, 2008		Received as Remuneration		Received on Exercise of Options		Net Change Other1		Balance June 30, 2009
	No.		No.		No.		No.		No.
Geoffrey Kempler		17,055,000		-		-		-		17,055,000
Brian Meltzer		326,666		-		-		-		326,666
George Mihaly		226,666		-		-		-		226,666
Peter Marks		43,111		-		-		-		43,111
Richard Revelins		20,308		-		-		-		20,308
Dianne Angus		250,000		-		-		-		250,000

		17,921,751		-		-		-		17,921,751

Fully Paid Ordinary Shares of the Company	Balance July 1, 2007		Received as Remuneration		Received on Exercise of Options		Net Change Other1			Balance June 30, 2008
	No.		No.		No.		No.			No.
Geoffrey Kempler		17,055,000		-		-		-			17,055,000
Colin Masters		184,666		-		-		(98,333	)		86,333
Brian Meltzer		326,666		-		-		-			326,666
George Mihaly		226,666		-		-		-			226,666
Peter Marks		43,111		-		-		-			43,111
Richard Revelins		20,308		-		-		-			20,308
Dianne Angus		-		-		250,000		-			250,000

		17, 856,417		-		250,000		(98,333	)		18,008,084

Fully Paid Ordinary Shares of the Company

Balance July 1, 2008

Received as Remuneration

Received on Exercise of Options

Net Change Other¹

Balance
June 30, 2009

No.

No.

No.

No.

No.

Geoffrey Kempler

17,055,000

–

–

–

17,055,000

Brian Meltzer

326,666

–

–

–

326,666

George Mihaly

226,666

–

–

–

226,666

Peter Marks

43,111

–

–

–

43,111

Richard Revelins

20,308

–

–

–

20,308

Dianne Angus

250,000

–

–

–

250,000

17,921,751

–

–

–

17,921,751

Fully Paid Ordinary Shares of the Company

Balance July 1, 2007

Received as Remuneration

Received on Exercise of Options

Net Change Other¹

Balance
June 30, 2008

No.

No.

No.

No.

No.

Geoffrey Kempler

17,055,000

–

–

–

17,055,000

Colin Masters

184,666

–

–

(98,333
)

86,333

Brian Meltzer

326,666

–

–

–

326,666

George Mihaly

226,666

–

–

–

226,666

Peter Marks

43,111

–

–

–

43,111

Richard Revelins¹

20,308

–

–

–

20,308

Dianne Angus

–

–

250,000

–

250,000

17, 856,417

–

250,000

(98,333
)

18,008,084

Fully Paid Ordinary Shares of the Company

Balance July 1, 2006

Received as Remuneration

Received on Exercise of Options

Net Change Other¹

Balance
June 30, 2007

No.

No.

No.

No.

No.

Geoffrey Kempler

17,055,000

–

–

–

17,055,000

Colin Masters

184,666

–

–

–

184,666

Brian Meltzer

326,666

–

–

–

326,666

George Mihaly

226,666

–

–

–

226,666

Peter Marks

43,111

–

–

–

43,111

Richard Revelins¹

92,808

–

–

(72,500
)

20,308

Ross Murdoch²

50,000

120,000

625,000

–

795,000

Dianne Angus

–

–

–

–

–

17,978,917

120,000

625,000

(72,500
)

18,651,417

¹These options were sold on market.

2~~The balance at June 30, 2007, is the balance~~Balance at date of ~~resignation.~~appointment, January 14, 2010.

F - 34

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

22. RELATED PARTY TRANSACTIONS (continued)

Share Options of the Company	Balance July 1, 2009 No.		Granted as Remuneration No.		Options Exercised No.		Options Forfeited No.		Options Expired No			Options Vested During 2009 fiscal year		Balance June 30, 2010 No.		Total Vested and Exercisable June 30, 2010 No.		Total Unvested June 30, 2010 No.
Geoffrey Kempler		3,000,000		-		-		-		(1,000,000	)		-		2,000,000		1,000,000		1,000,000
Brian Meltzer		950,000		-		-		-		(300,000	)		-		650,000		350,000		300,000
George Mihaly		950,000		-		-		-		(300,000	)		-		650,000		350,000		300,000
Peter Marks		950,000		-		-		-		(300,000	)		-		650,000		350,000		300,000
Paul Marks1		701,754		-		-		-		-			-		701,754		701,754		-
Richard Revelins		650,000		-		-		-		(300,000	)		-		350,000		350,000		-
Dianne Angus		1,694,837		292,256		-		-		-			-		1,987,093		1,792,256		194,837

		8,896,591		292,256		-		-		(2,200,000	)		-		6,988,847		4,894,010		2,094,837

Share Options of the Company	Balance July 1, 2008 No.		Granted as Remuneration No.		Options Exercised No.		Options Forfeited No.		Options Expired No		Options Vested During 2009 fiscal year		Balance June 30, 2009 No.		Total Vested and Exercisable June 30, 2009 No.		Total Unvested June 30, 2009 No.
Geoffrey Kempler		3,000,000				-		-		-		-		3,000,000		1,000,000		2,000,000
Brian Meltzer		950,000				-		-		-		-		950,000		350,000		600,000
George Mihaly		950,000				-		-		-		-		950,000		350,000		600,000
Peter Marks		950,000				-		-		-		-		950,000		350,000		600,000
Richard Revelins		650,000				-		-		-		-		650,000		350,000		300,000
Dianne Angus		1,500,000		194,837		-		-		-		-		1,694,837		1,500,000		194,837

		8,000,000		194,837		-		-		-		-		8,194,837		3,900,000		4,294,837

Share Options of the Company	Balance July 1, 2007 No.		Granted as Remuneration No.		Options Exercised No.			Options Forfeited No.			Options Expired No			Options Vested During 2008 fiscal year		Balance June 30, 2008 No.		Total Vest and Exercisable June 30, 2008 No.		Total Unvested June 30, 2008 No.
Geoffrey Kempler		2,000,000		1,000,000		-			-			-			1,000,000		3,000,000		1,000,000		2,000,000
Colin Master		2,000,000		-		-			(2,000,000	)		-			-		-		-		-
Brian Meltzer		600,000		350,000		-			-			-			350,000		950,000		350,000		600,000
George Mihaly		600,000		350,000		-			-			-			350,000		950,000		350,000		600,000
Peter Marks		600,000		350,000		-			-			-			350,000		950,000		350,000		600,000
Richard Revelins		800,000		350,000		-			-			(500,000	)		350,000		650,000		350,000		300,000
Dianne Angus		1,250,000		500,000		(250,000	)		-			-			750,000		1,500,000		1,500,000		-

		7,850,000		2,900,000		(250,000	)		(2,000,000	)		(500,000	)		3,150,000		8,000,000		3,900,000		4,100,000

For further information on equity entitlements under employment contracts, refer to Note 20.


~~22.~~	~~RELATED PARTY TRANSACTIONS (continued)~~

Share Options of
the Company

Balance
July 1, 2008
No.

Granted as Remuneration
No.

Options Exercised
No.

Options Forfeited
No.

Options Expired
No

Options Vested
During 2009 fiscal year

Balance
June 30, 2009
No.

Total Vested and Exercisable
June 30, 2009
No.

Total Unvested June 30, 2009
No.

Geoffrey Kempler

3,000,000

–

–

–

–

3,000,000

1,000,000

2,000,000

Brian Meltzer

950,000

–

–

–

–

950,000

350,000

600,000

George Mihaly

950,000

–

–

–

–

950,000

350,000

600,000

Peter Marks

950,000

–

–

–

–

950,000

350,000

600,000

Richard Revelins

650,000

–

–

–

–

650,000

350,000

300,000

Dianne Angus

1,500,000

194,837

–

–

–

–

1,694,837

1,500,000

194,837

8,000,000

194,837

–

–

–

–

8,194,837

3,900,000

4,294,837

Share Options of the Company

Balance
July 1, 2007
No.

Granted as Remuneration
No.

Options Exercised
No.

Options Forfeited
No.

Options Expired
No

Options Vested
During 2008 fiscal year

Balance
June 30, 2008
No.

Total Vest and Exercisable
June 30, 2008
No.

Total Unvested June 30, 2008
No.

Geoffrey Kempler

2,000,000

1,000,000

–

–

–

1,000,000

3,000,000

1,000,000

2,000,000

Colin Master

2,000,000

–

–

(2,000,000
)
–

–

–

–

–

Brian Meltzer

600,000

350,000

–

–

–

350,000

950,000

350,000

600,000

George Mihaly

600,000

350,000

–

–

–

350,000

950,000

350,000

600,000

Peter Marks

600,000

350,000

–

–

–

350,000

950,000

350,000

600,000

Richard Revelins

800,000

350,000

–

–

(500,000
)
350,000

650,000

350,000

300,000

Dianne Angus

1,250,000

500,000

(250,000
)
–

–

750,000

1,500,000

1,500,000

–

7,850,000

2,900,000

(250,000
)
(2,000,000
)
(500,000
)
3,150,000

8,000,000

3,900,000

4,100,000

Share Options of the Company

Balance
July 1, 2006
No.

Granted as Remuneration
No.

Options Exercised
No.

Options Forfeited
No.

Options Expired
No

Options Vested
During 2007 fiscal year

Balance
June 30, 2007
No.

Total Vest and Exercisable
June 30, 2007
No.

Total Unvested June 30, 2007
No.

Geoffrey Kempler

1,000,000

1,000,000

–

–

–

–

2,000,000

–

2,000,000

Colin Master

1,000,000

1,000,000

–

–

–

–

2,000,000

–

2,000,000

Brian Meltzer

300,000

300,000

–

–

–

–

600,000

–

600,000

George Mihaly

300,000

300,000

–

–

–

–

600,000

–

600,000

Peter Marks

300,000

300,000

–

–

–

–

600,000

–

600,000

Richard Revelins

500,000

300,000

–

–

–

–

800,000

300,000

500,000

Ross Murdoch¹

–

625,000

(625,000
)
–

–

625,000

–

–

–

Dianne Angus

–

1,250,000

–

–

–

1,000,000

1,250,000

1,000,000

250,000

3,400,000

5,075,000

(625,000
)
–

–

1,625,000

7,850,000

1,500,000

6,350,000

¹~~The balance at June 30, 2007, is the balance at date of resignation.~~

~~For further information on equity entitlements under employment contracts, refer to Note 20.~~

Balance at date of appointment, January 14, 2010.

F - 35

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)

23. SEGMENT INFORMATION


~~23.~~	~~SEGMENT INFORMATION~~

The consolidated entity’s activities are predominantly within Australia and cover research into Alzheimer’s disease and other major age-related degenerative disorders.


~~24.~~	~~FINANCIAL INSTRUMENTS~~

24. FINANCIAL INSTRUMENTS

The consolidated entity’s activities expose it to a variety of financial risks including market risk, credit risk and liquidity risk. The consolidated entity’s overall risk management program focuses on the unpredictability of financial markets and seeks to minimize potential adverse effects on the financial performance of the consolidated entity. Risk management is carried out under policies approved by the Board of Directors and overseen by the Audit, Risk and Compliance Committee.

(a) Market Risk

(i) Foreign Currency Risk

The consolidated entity engages in international purchase transactions and is exposed to foreign currency risk arising from various currency exposures, primarily with respect to the Australian dollar. The parent entity also has exposure to foreign exchange risk in the currency cash reserves it holds to meet ~~it’s~~it's foreign currency payments. The Group does not make use of derivative financial instruments to hedge foreign exchange risk.

The following financial assets and liabilities are subject to foreign currency risk, the currency of the original amounts are displayed in brackets, all the amounts in the table below are displayed in $AUD at year-end spot rates:

Consolidated Entity

2009

2008

$

$

Cash and cash equivalents ($USD)

211,286

301,751

Cash and cash equivalents (€EUR)

74,007

67,710

Cash and cash equivalents (£GBP)

725

73,230

Trade and other payables ($USD)

(53,338
)

(22,916
)
Trade and other payables (€EUR)

–

–

Trade and other payables (£GBP)

–

(957
)

Total exposure

232,680

418,818

	Consolidated Entity
	2010			2009
	$			$
Cash and cash equivalents ($USD)		105,940			211,286
Cash and cash equivalents (€EUR)		700,969			74,007
Cash and cash equivalents (£GBP)		1,153			725
Trade and other payables ($USD)		(6,898	)		(53,338	)
Trade and other payables (€EUR)		(130,110	)		-
Trade and other payables (£GBP)		-			-
Total exposure		671,054			232,680

The consolidated entity has conducted a sensitivity analysis of its exposure to foreign currency risk. The consolidated entity is currently exposed to the US dollar (USD), Euro (EUR) and Great British Pound (GBP). The sensitivity analysis below is conducted on a currency by currency basis using the sensitivity analysis variable, which has been based on the average annual movement in the AUD/USD, AUD/EUR and AUD/GBP exchange rates over the past five years based on the year-end spot rates. The variables for USD, EUR and GBP being 4%3%, 3% and ~~11%,~~12% respectively. ~~There has been no material change in the average annual movement in the AUD/EUR over the past five years based on the year-end spot rates.~~

Based on the financial instruments held at 30 June ~~30, 2009,~~2010, had the Australian dollar depreciated/appreciated by 4%3% against the ~~U.S.~~US dollar and the EURO with all other variables held constant, the consolidated entity’s post-tax profit for the year would have been ~~$7,249 lower / $8,508~~$19,512 lower/$20,719 higher ~~(2008: $10,719 lower / $12,580~~(2009: $6,756 lower/$7,174 higher), mainly as a result of foreign exchange gains/losses on translation of ~~U.S.~~US dollar denominated financial instruments as detailed in the above table. The consolidated ~~entity’s~~entity's exposure to other foreign exchange movements is not material.

F - 36

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~24.~~	~~FINANCIAL INSTRUMENTS (continued)~~

24. FINANCIAL INSTRUMENTS (continued)

(ii) Interest Rate Risk

The consolidated entity’s exposure to interest rate risk, which is the risk that a financial instrument’s value will fluctuate as a result of changes in market interest rates and the effective weighted average interest rates on classes of financial assets and financial liabilities.

The consolidated entity exposure to interest rate risk has not changed since the prior year.

At June 30, 2010, the consolidated entity had the following cash accounts:

· A$40,140 in Australia dollar cheque accounts at variable interest rates ranging from 0% to 1.11% as of June 30, 2010;

· A$5,084 in Australia dollar savings accounts at an interest rate of 3.5% as of June 30, 2010;

· A$203,745 in Australia dollar transaction accounts at variable rates ranging from 0% to 1.72% as of June, 2010.

· A$4,169,347 in Australia Business Cash High Interest accounts at an interest rate of 4.5% as of June 2010;

· A$325 in Australia dollar Business Cash accounts at an interest rate of 4.45% as of June 2010;

· US$89,150 (A$104,109) in a U.S. checking account at a interest rate of 0% as of June 30, 2010;

· EUR$491,157 (A$700,242) in a EUR cheque account at a variable interest rate of 0% as of June 30, 2010;

· A$35,164 in a six month term deposit at a fixed interest rate of 5.80% which matures on 11 September 2010;

· A$200 in petty cash which does not earn any interest;

· GBP$655 (A$1,153) in petty cash which does not earn any interest;

· SEK$970 (A$145) in petty cash which does not earn any interest;

· INR$9,930 (A$250) in petty cash which does not earn any interest;

· US$1,568 (A$1,831) in petty cash which does not earn any interest; and

· EUR$510 (A$727) in petty cash which does not earn any interest.

The weighted average interest rate is 3.67% for cash and cash equivalents and 0.13% for terms deposits over three months and apart from usual variances in general rates of interest the consolidated entity is not exposed to any significant interest rate risk.

At June 30, 2009, the consolidated entity had the following cash accounts:


·	~~A$53,671 in Australia dollar cheque accounts at variable interest rates ranging from 0.02% to 1.36% as of June 30, 2009;~~
·	~~A$5,292 in Australia dollar savings accounts at an interest rate of 2% as of June 30, 2009;~~
·	~~A$16,882 in Australia dollar transaction accounts at variable rates ranging from 0% to 0.05% as of June, 2009.~~
·	~~A$3,942,443 in Australia Business Cash High Interest accounts at an interest rate of 3% as of June 2009;~~
·	~~A$313 in Australia dollar Business Cash accounts at an interest rate of 2.5% as of June 2009~~
·	~~US$168,039 (A$208,872) in a U.S. checking account at a interest rate of 0% as of June 30, 2009;~~
·	~~GBP$179 (A$368) in a GBP cheque account at a variable interest rate of 0% as of June 30, 2009;~~
·	~~EUR$40,833(A$81,715) in a EUR cheque account at a variable interest rate of 0% as of June 30, 2009;~~
·	~~A$35,164 in a six month term deposit at a fixed interest rate of 3.70% which matures on 11 August 2009;~~
·	~~A$200 in petty cash which does not earn any interest;~~
·	~~GBP$174 (A$357) in petty cash which does not earn any interest;~~
·	~~SEK$970 (A$156) in petty cash which does not earn any interest;~~
·	~~US$1,942 (A$2,414) in petty cash which does not earn any interest; and~~
·	~~CA$2 (A$2) in petty cash which does not earn any interest.~~

· A$53,671 in Australia dollar cheque accounts at variable interest rates ranging from 0.02% to 1.36% as of June 30, 2009;

· A$5,292 in Australia dollar savings accounts at an interest rate of 2% as of June 30, 2009;

· A$16,882 in Australia dollar transaction accounts at variable rates ranging from 0% to 0.05% as of June, 2009.

· A$3,942,443 in Australia Business Cash High Interest accounts at an interest rate of 3% as of June 2009;

· A$313 in Australia dollar Business Cash accounts at an interest rate of 2.5% as of June 2009;

· US$168,039 (A$208,872) in a U.S. checking account at a interest rate of 0% as of June 30, 2009;

· GBP$179 (A$368) in a GBP cheque account at a variable interest rate of 0% as of June 30, 2009;

· EUR$40,833(A$81,715) in a EUR cheque account at a variable interest rate of 0% as of June 30, 2009;

· A$35,164 in a six month term deposit at a fixed interest rate of 3.70% which matures on 11 August 2009;

· A$200 in petty cash which does not earn any interest;

· GBP$174 (A$357) in petty cash which does not earn any interest;

· SEK$970 (A$156) in petty cash which does not earn any interest;

· US$1,942 (A$2,414) in petty cash which does not earn any interest; and

· CA$2 (A$2) in petty cash which does not earn any interest.

The weighted average interest rate is 2.77% for cash and cash equivalents and 0.59% for terms deposits over three months and apart from usual variances in general rates of interest the consolidated entity is not exposed to any significant interest rate risk.

~~At June 30, 2008, the consolidated entity had the following cash accounts:~~


·	~~A$25,554 in Australia dollar cheque accounts at variable interest rates ranging from 0.10% to 6.25% as of June 30, 2008;~~
·	~~A$6,800,000 in a three month term deposit at a fixed interest rate of 7.95% as of June 30, 2008;~~
·	~~A$3,950,416 in at call deposit account, earning interest of 7.20% as of June 30, 2008;~~
·	~~US$286,264 (A$298,029) in a U.S. checking account at a interest rate of 1.43% as of June 30, 2008;~~
·	~~GBP$35,075 (A$72,869) in a GBP cheque account at a variable interest rate of 3.57% as of June 30, 2008;~~
·	~~EUR$41,166 (A$67,710) in a EUR cheque account at a variable interest rate of 3.16% as of June 30, 2008;~~
·	~~A$11,064 in a 12 month term deposit at a fixed interest rate of 7.25%which matures on 13 January 2009;~~
·	~~A$35,164 in a three month term deposit at a fixed interest rate of 6.30%which matures on 11 August 2008;~~
·	~~A$200 in petty cash which does not earn any interest;~~
·	~~GBP$174 (A$361) in petty cash which does not earn any interest;~~
·	~~SEK$970 (A$169) in petty cash which does not earn any interest;~~
·	~~US$3,575 (A$3,727) in petty cash which does not earn any interest; and~~
·	~~CA$5 (A$5) in petty cash which does not earn any interest.~~

The weighted average interest rate is 7.45% for cash and cash equivalents and 6.53% for terms deposits over three months and apart from usual variances in general rates of interest the consolidated entity is not exposed to any significant interest rate risk.

F - 37

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~24.~~	~~FINANCIAL INSTRUMENTS (continued)~~

24. FINANCIAL INSTRUMENTS (continued)

Receivables and payables are non-interest bearing.

The consolidated entity’s exposure to interest rates and the effective weighted average interest rate for classes of financial assets and liabilities is set out below:

June 30, 2009

Floating
Interest Rate

Fixed Interest
Maturing in

Non-Interest bearing

Total

Average Interest Rate

1 year
or less

1-5 years

Financial Assets

Cash and cash equivalents

$
4,299,229

–

–

$
5,748

$
4,304,977

2.77
%
Trade and other receivables

–

–

$
526

$
526

Other current assets

–

$
35,164

–

$
185,433

$
220,597

0.59
%

$
4,299,229

$
35,164

–

$
191,707

$
4,526,100

Financial Liabilities

Payables

–

–

–

$
604,142

$
604,142

Other financial liabilities

–

–

–

–

–

–

–

–

$
604,142

$
604,142

June 30, 2008

Floating
Interest Rate

Fixed Interest
Maturing in

Non-Interest bearing

Total

Average Interest Rate

1 year
or less

1-5 years

Financial Assets

Cash

$
464,162

$
10,750,416

–

$
4,456

$
11,219,035

7.45
%
Receivables

–

–

–

$
120,641

$
120,641

Other current assets

–

$
46,228

–

$
243,261

$
289,489

6.53
%

$
464,162

$
10,796,644

–

$
368,359

$
11,629,165

Financial Liabilities

Payables

–

–

–

$
849,113

$
849,113

Other financial liabilities

–

–

–

$
772,430

$
772,430

–

–

–

$
1,621,543

$
1,621,543

June 30, 2010	Floating Interest Rate		Fixed Interest Maturing in				Non-Interest bearing		Total		Average Interest Rate

			1 year or less		1-5 years
Financial Assets
Cash and cash equivalents	$	5,222,992		-		-	$	4,306	$	5,227,298		3.67	%
Trade and other receivables		-		-		-	$	825	$	825
Other current assets		-	$	35,164		-	$	1,479,603	$	1,514,767		0.13	%

Total Financial Assets	$	5,222,992	$	35,164		-	$	1,484,734	$	6,742,890

Financial Liabilities
Payables		-		-		-	$	1,244,417	$	1,244,417
Other financial liabilities		-		-		-		-		-

Total Financial Liabilities		-		-		-	$	1,244,417	$	1,244,417

June 30, 2009	Floating Interest Rate		Fixed Interest Maturing in				Non-Interest bearing		Total		Average Interest Rate

			1 year or less		1-5 years
Financial Assets
Cash and cash equivalents	$	4,299,229		-		-	$	5,748	$	4,304,977		2.77	%
Trade and other receivables		-		-		-	$	526	$	526
Other current assets		-	$	35,164		-	$	185,433	$	220,597		0.59	%

Total Financial Assets	$	4,299,229	$	35,164		-	$	191,707	$	4,526,100

Financial Liabilities
Payables		-		-		-	$	604,142	$	604,142
Other financial liabilities		-		-		-		-		-

Total Financial Liabilities		-		-		-	$	604,142	$	604,142

F - 38

PRANA BIOTECHNOLOGY LIMITED

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)


~~24.~~	~~FINANCIAL INSTRUMENTS (continued)~~

24. FINANCIAL INSTRUMENTS (continued)

(b) Credit Risk

Credit risk refers to the risk that a counterparty will default on its contractual obligations resulting in financial loss to the consolidated entity. The consolidated entity has no significant concentration of credit risk and it is not the Company’s policy to hedge credit risk.

The Company ensures that surplus cash is invested with financial institutions of appropriate credit worthiness and limits the amount of credit exposure to any one counter party.

There has been no significant change in the consolidated entity’s exposure to credit risk since the previous year. The carrying amount of the consolidated entity’s financial assets represent the maximum credit exposure.

(c) Liquidity Risk

Prudent liquidity risk management implies maintaining sufficient cash and the availability of funding through an adequate amount of committed credit facilities. The consolidated entity manages liquidity risk by maintaining sufficient bank balances to fund its operations and the availability of funding through committed credit facilities.

Management monitors rolling forecasts of the ~~Group’s~~consolidated entity’s liquidity reserve on the basis of expected cash flows.

~~Maturities of Financial Liabilities~~

2009

Less than 6 months

6-12 months

Total contracted cash flows

Carrying amounts

Consolidated Entity

Trade and other payables

604,142

604,142

604,142

Other financial liabilities

–

–

–

Parent

Trade and other payables

602,782

602,782

602,782

Other financial liabilities

–

–

–

2008

Consolidated Entity

Trade and other payables

849,113

–

849,113

849,113

Other financial liabilities

772,430

–

772,430

772,430

Parent

Trade and other payables

848,072

–

848,072

848,072

Other financial liabilities

772,430

–

772,430

772,430

Maturities of Financial Liabilities

2010 Less than 6 months 6-12 months Total contracted cash flows Carrying amounts
Consolidated Entity
Trade and other payables 1,244,417 - 1,244,417 1,244,417

2009
Consolidated Entity
Trade and other payables 604,142 - 604,142 604,142

(d) Capital Risk Management

The consolidated ~~entity’s~~entity's objectives when managing capital are to safeguard the consolidated ~~entity’s~~entity's ability to continue as a going concern and to maintain an optimal capital structure so as to maximize shareholder value. In order to maintain or achieve an optimal capital structure, the consolidated entity may issue new shares or reduce its capital, subject to the provisions of the ~~Company’s~~Company's constitution. The capital structure of the consolidated entity consists of equity attributed to equity holders of the consolidated entity, comprising contributed equity, reserves and accumulated losses disclosed in Notes 12, 13 and 14. By monitoring undiscounted cash flow forecasts and actual cash flows provided to the Board by the ~~Company’s~~Company's Management the Board monitors the need to raise additional equity from the equity ~~markets.~~

mar kets.

(e) Fair Value Estimation

The carrying amount of financial assets and financial liabilities recorded in the financial statements represents their respective fair values, determined in accordance with the accounting policies disclosed in Note 1 to the financial statements.

F - 39

~~PRANA BIOTECHNOLOGY LIMITED~~25.ADDITIONAL COMPANY INFORMATION

~~NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – in Australian dollars (unless otherwise noted)~~


~~25.~~	~~ADDITIONAL COMPANY INFORMATION~~

Prana Biotechnology Limited is a listed public company, incorporated and operating in Australia.


Registered Office	Principal Place of Business
Suite 2		Level 2
~~Suite 2~~	~~Level 2~~
1233 High Street	369 Royal Parade
Armadale Vic 3143	Parkville Vic 3052
Australia	Australia

Tel: +61 (03) 9824 8166	Tel: +61 (03) 9349 4906

F - 40

SIGNATURES

The Registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this report on its behalf.

		Prana Biotechnology Limited

	By: ~~/s/~~	/s/ Geoffrey P. Kempler ~~——————————————~~
		Geoffrey P. Kempler
		Chief Executive Officer

Dated: ~~September 23, 2009~~

November 9, 2010

Year Ended June 30,




2005	0.7620	0.7535	0.7988	0.6852
2006	0.7301	0.7478	0.7792	0.7014
2007	0.8488	0.7859	0.8521	0.7377
2008	0.9615	0.8965	0.9654	0.7672
2009	0.8048	0.7480	0.9849	0.6005

Month




April 2009	0.7327	0.6846
May 2009	0.8012	0.7232
June 2009	0.8262	0.7789
July 2009	0.8271	0.7793
August 2009	0.8477	0.8155
September 2009 (until September 21)	0.8774	0.8239

Name




Geoffrey P. Kempler	19,055,000	(3)(4)	8.11	%
Richard Revelins	370,308	(5)(6)	*
Dianne Angus	1,944,837	(7)(8)	*
Peter Marks	693,111	(9)(10)	*
Brian D. Meltzer	976,666	(11)(12)	*
George W. Mihaly	876,666	(13)(14)	*
All directors and executive
officers as a group (six
persons)	23,916,588	(15)	10.1	%

Name




BAM Opportunity Fund, L.P.	30,000,000	(3)	12.88	%
Geoffrey P. Kempler	19,055,000	(4)(5)	8.11	%
Jagen Nominees Pty Ltd.	15,689,172	(6)	6.73	%
Balyasny Asset Management LP.	12,836,682	(7)	5.51	%


Fiscal Year Ended June 30, 2008:
First Quarter	3.10	2.20
Second Quarter	4.05	2.06
Third Quarter	6.73	3.25
Fourth Quarter	4.45	3.56

Fiscal Year Ended June 30, 2009:
First Quarter	5.70	3.20
Second Quarter	3.50	1.30
Third Quarter	3.11	1.00
Fourth Quarter	1.75	1.14

Month Ended:
March 2009	1.65	1.00
April 2009	1.75	1.33
May 2009	1.60	1.14
June 2009	1.48	1.20
July 2009	1.80	1.05
August 2009	2.17	1.45






Balance, June 30, 2006		128,144,260	46,274,127	2,867,249		(41,340,718	)	7,800,658

Net loss	14	-	-	-		(11,142,320	)	(11,142,320	)
Issuance of shares in connection with
private placement, net of costs	12(b)	22,014,468	6,108,868	-		-		6,108,868
Issuance of options in connection with
private placement	12(c)	-	1,262,339	-		-		1,262,339
Non-cash issuance of shares to consultants	12(b)	481,250	194,579	-		-		194,579
Non-cash issuance of shares to employees	12(b)	120,000	45,600	-		-		45,600
Non-cash issuance of options to
consultants	13(b)	-	-	163,701		-		163,701
Non-cash issuance of options to directors
and employees	13(b)	-	-	989,721		-		989,721
Issuance of shares in connection with	12(b)&
exercise of options, net of costs	13(b)	758,000	102,899	(106,739	)	-		(3,840	)
Amortization of option expenses	13(b)	-	-	195,839		-		195,839
Options forfeited	13(b)	-	-	(2,950	)	-		(2,950	)

Balance, June 30, 2007		151,517,978	53,988,412	4,106,821		(52,483,038	)	5,612,195

Net loss	14	-	-	-		(13,560,678	)	(13,560,678	)
Issuance of shares in connection with
private placement, net of costs	12(b)	47,903,699	13,717,248	-		-		13,717,248
Issuance of options in connection with
private placement	12(c)	-	1,439,305	-		-		1,439,305
Non-cash issuance of shares to consultants	12(b)	985,000	288,402	-		-		288,402
Non-cash issuance of options to
consultants	13(b)	-	-	482,150		-		482,150
Non-cash issuance of options to directors
and employees	13(b)	-	-	1,467,359		-		1,467,359
Issuance of shares in connection with	12(b)&
exercise of options, net of costs	13(b)	1,393,563	408,936	(408,936	)	-		-
Amortization of option expenses	13(b)	-	-	563,479		-		563,479
Options forfeited	13(b)	-	-	(143,133	)	-		(143,133	)

Balance, June 30, 2008		201,800,240	69,842,303	6,067,740		(66,043,716	)	9,866,327
Net loss	14	-	-	-		(7,522,789	)	(7,522,789	)
Issuance of shares in connection with
private placement, net of costs	12(b)	-	-	-		-		-
Issuance of options in connection with
private placement	12(c)	-	-	-		-		-
Non-cash issuance of shares to consultants	12(b)	93,750	128,932	-		-		128,932
Non-cash issuance of options to
consultants	13(b)	-	-	622,700		-		622,700
Non-cash issuance of options to directors
and employees	13(b)	-	-	138,213		-		138,213
Issuance of shares in connection with	12(b)&
exercise of options, net of costs	13(b)	816,483	217,754	(217,754	)	-		-
Amortization of option expenses	13(b)	-	-	516,433		-		516,433
Option forfeited	13(b)	-	-	-		-		-

Balance, June 30, 2009		202,710,473	70,188,989	7,127,332		(73,566,505	)	3,749,816

(a) The prima facie tax on net (loss) before tax
is reconciled to the income tax is as follows:
Prima facie tax income on net (loss) before
income tax at 30%
(2008 & 2007: 30%)	(2,256,837	)	(4,068,203	)	(3,342,696	)
Effect of lower tax rates of tax on overseas
income	48		(286	)	442

Add tax effect of:
(Over) provision of income tax in previous year
relating to a correction of estimates¹	13,806		(288	)	(2,697,461	)
Equity issued for nil consideration	391,641		744,547		473,740
Research and development tax concession	(258,131	)	(552,400	)	(434,117	)
Gain on fair value of financial liabilities	(231,729	)	135,429		(182,307	)
Other	1,701		116		2,452

Deferred tax asset not recognized	2,339,501		3,740,797		6,179,947

Income tax expense attributable to loss before
income tax	-		-		-


(b) Potential deferred tax asset at June 30,
2009, 2008 and 2007 in respect of tax losses not
brought to account is:	28,809,746		26,396,277		22,693,134
Temporary Differences	246,714		1,242,278		392,720

Accrued income	526	89,569
Goods and services tax receivable	-	31,072


	526	120,641

Trade creditors	109,871	172,204
Accrued research and development expenses	248,304	419,244
Accrued intellectual property expenses	111,217	19,313
Accrued personnel expenses	246	657
Accrued audit fees	124,069	122,993
Accrued marketing expenses	-	54,939
Other accrued expenses	10,435	59,763


Total	604,142	849,113


Date	Details	Exercise Price		Number		Fair Value	$


October 30, 2007	Options to investors as part of a capital raising	$	0.37		3,628,598	0.15		544,290
October 30, 2007	Options to investors as part of a capital raising	$	0.43		3,628,598	0.14		508,004
October 30, 2007	Options to investors as part of a capital raising	$	0.37		1,188,323	0.15		178,248
October 30, 2007	Options to investors as part of a capital raising	$	0.43		1,188,323	0.14		166,365
October 30, 2007	Options to investors as part of a capital raising	$	0.37		146,199	0.15		21,930
October 30, 2007	Options to investors as part of a capital raising	$	0.43		146,199	0.14		20,468

Year ended June 30, 2008					9,926,240			1,439,305

Year ended June 30, 2009					–			–


Share Options of the Company	Balance July 1, 2008 No.	Granted as Remuneration No.	Options Exercised No.		Options Forfeited No.		Options Expired No		Options Vested During 2009 fiscal year	Balance June 30, 2009 No.	Total Vested and Exercisable June 30, 2009 No.	Total Unvested June 30, 2009 No.


Geoffrey Kempler	3,000,000		–		–		–		–	3,000,000	1,000,000	2,000,000
Brian Meltzer	950,000		–		–		–		–	950,000	350,000	600,000
George Mihaly	950,000		–		–		–		–	950,000	350,000	600,000
Peter Marks	950,000		–		–		–		–	950,000	350,000	600,000
Richard Revelins	650,000		–		–		–		–	650,000	350,000	300,000
Dianne Angus	1,500,000	194,837	–		–		–		–	1,694,837	1,500,000	194,837

	8,000,000	194,837	–		–		–		–	8,194,837	3,900,000	4,294,837

Share Options of the Company	Balance July 1, 2007 No.	Granted as Remuneration No.	Options Exercised No.		Options Forfeited No.		Options Expired No		Options Vested During 2008 fiscal year	Balance June 30, 2008 No.	Total Vest and Exercisable June 30, 2008 No.	Total Unvested June 30, 2008 No.


Geoffrey Kempler	2,000,000	1,000,000	–		–		–		1,000,000	3,000,000	1,000,000	2,000,000
Colin Master	2,000,000	–	–		(2,000,000	)	–		–	–	–	–
Brian Meltzer	600,000	350,000	–		–		–		350,000	950,000	350,000	600,000
George Mihaly	600,000	350,000	–		–		–		350,000	950,000	350,000	600,000
Peter Marks	600,000	350,000	–		–		–		350,000	950,000	350,000	600,000
Richard Revelins	800,000	350,000	–		–		(500,000	)	350,000	650,000	350,000	300,000
Dianne Angus	1,250,000	500,000	(250,000	)	–		–		750,000	1,500,000	1,500,000	–

	7,850,000	2,900,000	(250,000	)	(2,000,000	)	(500,000	)	3,150,000	8,000,000	3,900,000	4,100,000

Share Options of the Company	Balance July 1, 2006 No.	Granted as Remuneration No.	Options Exercised No.		Options Forfeited No.		Options Expired No		Options Vested During 2007 fiscal year	Balance June 30, 2007 No.	Total Vest and Exercisable June 30, 2007 No.	Total Unvested June 30, 2007 No.


Geoffrey Kempler	1,000,000	1,000,000	–		–		–		–	2,000,000	–	2,000,000
Colin Master	1,000,000	1,000,000	–		–		–		–	2,000,000	–	2,000,000
Brian Meltzer	300,000	300,000	–		–		–		–	600,000	–	600,000
George Mihaly	300,000	300,000	–		–		–		–	600,000	–	600,000
Peter Marks	300,000	300,000	–		–		–		–	600,000	–	600,000
Richard Revelins	500,000	300,000	–		–		–		–	800,000	300,000	500,000
Ross Murdoch¹	–	625,000	(625,000	)	–		–		625,000	–	–	–
Dianne Angus	–	1,250,000	–		–		–		1,000,000	1,250,000	1,000,000	250,000

	3,400,000	5,075,000	(625,000	)	–		–		1,625,000	7,850,000	1,500,000	6,350,000


June 30, 2009	Floating Interest Rate		Fixed Interest Maturing in				Non-Interest bearing		Total		Average Interest Rate

			1 year or less		1-5 years


Financial Assets
Cash and cash equivalents	$	4,299,229		–		–	$	5,748	$	4,304,977	2.77	%
Trade and other receivables		–				–	$	526	$	526
Other current assets		–	$	35,164		–	$	185,433	$	220,597	0.59	%


	$	4,299,229	$	35,164		–	$	191,707	$	4,526,100



Financial Liabilities
Payables		–		–		–	$	604,142	$	604,142
Other financial liabilities		–		–		–		–		–


		–		–		–	$	604,142	$	604,142



June 30, 2008	Floating Interest Rate		Fixed Interest Maturing in				Non-Interest bearing		Total		Average Interest Rate

			1 year or less		1-5 years


Financial Assets
Cash	$	464,162	$	10,750,416		–	$	4,456	$	11,219,035	7.45	%
Receivables		–		–		–	$	120,641	$	120,641
Other current assets		–	$	46,228		–	$	243,261	$	289,489	6.53	%


	$	464,162	$	10,796,644		–	$	368,359	$	11,629,165



Financial Liabilities
Payables		–		–		–	$	849,113	$	849,113
Other financial liabilities		–		–		–	$	772,430	$	772,430


		–		–		–	$	1,621,543	$	1,621,543


2009	Less than 6 months	6-12 months	Total contracted cash flows	Carrying amounts


		Consolidated Entity
Trade and other payables	604,142		604,142	604,142
Other financial liabilities	–		–	–

		Parent
Trade and other payables	602,782		602,782	602,782
Other financial liabilities	–		–	–

2008
		Consolidated Entity
Trade and other payables	849,113	–	849,113	849,113
Other financial liabilities	772,430	–	772,430	772,430

		Parent
Trade and other payables	848,072	–	848,072	848,072
Other financial liabilities	772,430	–	772,430	772,430

Maturities of Financial Liabilities

2010	Less than 6 months	6-12 months	Total contracted cash flows	Carrying amounts
		Consolidated Entity
Trade and other payables	1,244,417	-	1,244,417	1,244,417

2009
		Consolidated Entity
Trade and other payables	604,142	-	604,142	604,142