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As filed with the Securities and Exchange Commission on September 24, 2001August 28, 2003

RegistrationCommission File No.: 333-          



UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FormFORM S-3
REGISTRATION STATEMENT
UnderUNDER
THE SECURITIES ACT OF 1933


TRANSGENOMIC, INC.

(Exact nameName of registrant as specified in its charter)Registrant As Specified In Its Charter)

Delaware
(State of Incorporation)
 91-1789357
(IRS Employer I.D. Number)

12325 Emmet Street
Omaha, Nebraska 68164
(402) 452-5400

(State or other jurisdictionAddress, including zip code, and telephone number, including
area code, of registrant's principal executive offices)

incorporation or organization)
Collin J. D'Silva
President and Chief Executive Officer
12325 Emmet Street
Omaha, Nebraska 68164
(402) 452-5400

(I.R.S. Employer
Identification No.)Name, address and telephone number of Agent for Service)

12325 Emmet Street,
Omaha, Nebraska 68164
(402) 452-5400
Copies to:

(Address, including zip code, and telephone number, including area code,
of registrant's principal executive offices)

Collin J. D'Silva
President and Chief Executive Officer
12325 Emmet Street
Omaha, Nebraska 68164
(402) 452-5400

(Name, address, including zip code, and telephone number, including area code, of agent for service)

with copies to:
Steven P. Amen

Kutak Rock LLP
1650 Farnam Street
Omaha, Nebraska 68102
Tel: (402) 346-6000

Fax: (402) 346-1148


Approximate date of commencement of proposed sale to the public:APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
From time to time after the effective date of this Registration Statement
as determined by market conditions.

        If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box.o/ /

        If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box.ý/x/

        If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.o/ /

        If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.o/ /

        If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box.o/ /

CALCULATION OF REGISTRATION FEECalculation of Registration Fee


Title of Shares To be Registered Amount to Be Registered Proposed Maximum Aggregate Price per Share(1) Proposed Maximum Aggregate Offering Price Amount of Registration Fee

Common Stock, $0.01 par value 4,773,699 $7.35 $35,086,687 $8,772


Title of each class of
securities to be registered

 Amount to
be registered

 Proposed maximum
offering price
per share(1)

 Proposed maximum
aggregate
offering price(1)

 Amount of
registration fee


Common Stock, par value $.01 per share 4,500,000 $1.12 $5,040,000 $407.74

(1)
Estimated solely for the purpose of calculatingcomputing the amount of the registration fee in accordance with Rule 457(c). Based under the Securities Act of 1933, as amended. Estimate based on the closing saleaverage of the high and low prices of a share of Transgenomic, Inc.the Registrant's common stock on September 19, 2001 as reported by the Nasdaq Stock Market.National Market on August 26, 2003 pursuant to Rule 457(c) promulgated under the Securities Act of 1933, as amended.

        The registrant hereby amendsWe will amend this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shallwe file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until thethis Registration Statement shall become effective on such date as the Commission, acting pursuantaccording to said Section 8(a), may determine.




This ProspectusSUBJECT TO COMPLETION, DATED AUGUST 28, 2003

PRELIMINARY PROSPECTUS

The information in this prospectus is not complete and may be changed. These securities may not be sold until the information contained herein are subject to completion or amendment. A registration statement relating to these securities has been filed with the Securities and Exchange Commission. These securities may not be sold nor may offers to buy be accepted prior to the time the registration statement becomesCommission is effective. This Prospectus shallprospectus is not constitute an offer to sell or the solicitation ofthese securities and is not seeking an offer to buy nor shall there be any sale of these securities in any State in which suchstate where the offer solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such State.is not permitted.

PRELIMINARY PROSPECTUS DATED SEPTEMBER 24, 2001

4,773,6994,500,000 Shares

LOGOTRANSGENOMIC, INC.

Common StockCOMMON STOCK

        The holders of 4,773,6994,500,000 shares of our common stock may sell some or all of these shares under this prospectus. These stockholders may sell the shares at the then prevailing market price for the shares at the time of the sale, or at other prices. The last reported sale price for our common stock on August 27, 2003 was $1.14 per share. We will not receive any of the proceeds from the sale of these shares by these stockholders.

        In July, 2000 we sold 5,152,000 shares of our common stock in our initial public offering. The underwriters of our initial public offering are not underwriting any of the shares being sold by the selling stockholders. Prior to our initial public offering, there was no public market for our common stock.


Our common stock is listed on the Nasdaq National Market under the symbol TBIO."TBIO."


        The selling stockholders are offering the common stock as described under "Plan of Distribution."


        Investing in theour common stock involves a high degree of risk. SeeYou should carefully consider the information under the heading "Risk Factors" beginning on page 6.5 of this Prospectus before buying shares of our common stock.


        Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.


September                        , 20012003



TABLE OF CONTENTS


Page
Prospectus SummaryABOUT THIS PROSPECTUS 31
Risk Factors
TRANSGENOMIC, INC.

 
6
1
Forward-Looking Statements
RISK FACTORS

 

5

USE OF PROCEEDS


7

SELLING STOCKHOLDERS


7

PLAN OF DISTRIBUTION


9

EXPERTS


10

LEGAL OPINIONS


11
Selling Stockholders
WHERE YOU CAN FIND MORE INFORMATION

 
12
11
Plan of Distribution
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

 
16
Legal Matters17
Experts17
Where You Can Find More Information18
Incorporation of Certain Documents by Reference18
11

Forward-Looking Statements

This prospectus contains referencesor incorporates by reference certain forward-looking statements. Many of these forward-looking statements refer to our plans, objectives, expectations and intentions, as well as our future financial results and are subject to risk and uncertainty. You can identify these forward-looking statements by words such as "expects," "anticipates," "intends," "plans," "may," "will," "believes," "seeks," "estimates" and similar expressions. Because these forward-looking statements involve risks and uncertainties, there are many factors that could cause our actual results to differ materially from those expressed or implied by these forward-looking statements, including those discussed under "Risk Factors" in this Prospectus or described in reports that we file from time to time with the Securities and Exchange Commission, such as our Forms 10-K and 10-Q.


        You should rely only on the information contained in or incorporated by reference into this Prospectus. We have not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. The information in this Prospectus is current as of its date. Our business, financial condition, results of operations and prospects may have changed since that date.

        This Prospectus references the following registered trademarks WAVE® and DNASep®. WAVEMaker™, WAVE Optimized™which are the property of Transgenomic: DNASEP® Columns, WAVE® System, WAVEMAKER® Software, TRANSFORMING THE WORLD® for Laboratory Equipment, TRANSGENOMIC® and the Transgenomic nameGlobe Logo®; MutationDiscovery.com® Website, OLIGOSEP® for Systems and Reagents, OPTIMASE® Polymerase, RNASEP® Columns, WAVE OPTIMIZED® reagents, and WAVE® MD Systems. Additionally, this Prospectus references the Transgenomic logofollowing trademarks which are our trademarks.the property of Transgenomic: DHPLC™ or Education Programs, FIRST BASE™ Linkers, MitoScreen™ Kits, ProtocolWriter™ Software, Navigator™ Software, THE POWER OF DISCOVERY™ for Lab Reagents and Educational Programs, and Surveyor™ Nuclease. All other trademarks or trade names referred to in this prospectusProspectus are the property of their respective owners.

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ABOUT THIS PROSPECTUS SUMMARY

        The summary highlights selected information contained in or incorporated into this prospectus. This summaryProspectus does not contain all of the information you shouldneed to consider before investing inbuying our common stock. Additional important information is contained in the documents that are incorporated by reference into this Prospectus, including more detailed financial statements and the notes thereto. See "Incorporation of Certain Documents By Reference." As a result, information presented in this Prospectus is qualified in its entirety by this additional information. We urge you to carefully read this entire prospectusProspectus, along with the additional information that is incorporated by reference into this prospectus. YouProspectus, before investing in our common stock. In particular, you should carefully consider the information discussed under "Risk Factors" before you decide. All references to purchase our common stock."we," "us" or the "Company" in this Prospectus mean Transgenomic, Inc.


TRANSGENOMIC, INC.

Our Business

        We provide innovative tools for the separation and analysis of nucleic acids to researchers seeking to discover and understand variations in the human genetic code and the relationship of these variations to disease. In addition, our tools are versatile and can be used for size-based double-strand DNA separation and analysis, single-strand DNA separation and analysis and DNA purification. Effective May 1, 2001, we acquired Annovis, Inc, a specialty chemicals company that develops, manufactures and markets a wide variety of nucleic acid-based products and services for the life sciences industry. This acquisition expandssynthesis, purification and analysis of nucleic acids. Our operations fall into two principal segments, BioSystems and Nucleic Acids. Our BioSystems products include our WAVE® automated instrument systems and associated consumable product offerings.products. Our Nucleic Acids products include chemical building blocks for nucleic acid synthesis and synthesized nucleic acids. Our service offerings include genetic variation discovery services, novel chemistry development services and custom synthesis of nucleic acids. Our business planstrategy is to focus on providing enabling toolsalign our products and services with the advancements in the field of genetics and to become a major supplier of products and services to researchers, medical institutions, diagnostic and pharmaceutical companies. Specifically, our strategy is to:

        Our technologies center around three core competencies: separation chemistries, enzymology, and nucleic acid chemistries. We employ novel chemistries for separating nucleic acids, proteins, peptides, amino acids and carbohydrates. One of our significant separation technologies is currently embodied in the WAVE System. The WAVE System is a versatile systeminstrument that can be used for variation detection, size-based double-strand DNA separation and analysis, single-strand DNA separation and analysis and DNA purification. Because of this versatility, theThe WAVE System can essentially replacerequires the use of traditional gel electrophoresisvarious consumable products that we manufacture and sell separately.

        Our second core competency is expertise in developing novel enzymes. Enzymes are proteins that act as catalysts for biochemical reactions. Several of these reactions are useful in genomics. The ability to develop enzymes useful in the molecular biology laboratory. Our patented technology uses a process known as high performance liquid chromatographyexperimental manipulation of genes provides powerful tools for producing genetic material in the form needed for further analysis or incorporation into diagnostics and therapeutics. These products can also expand the sale of consumable products to separate DNA material so that genetic variationWAVE System users and may also be identified and analyzed. In this process, DNA is injected into a special tube or column containing microscopic polymer beads. These micro-beads have special surface chemistries that cause the DNA molecules to attach to the surface of the beads. A chemical reagent is then pumped through the column under carefully controlled pressure and temperature conditions causing the DNA molecules to be selectively released from the beads so that they can be separated and measured. Our proprietary software controls the entire process and produces the results of the operation in an easy-to-read chart format. Once the DNA sample is loaded into the instrument and necessary data is entered into the software, the process requires virtually no additional input from the researcher. By using our patented DNASep®, OLIGOSep® and RNASep™ columns and specifically formulated reagents that we have developedsold for various applications, the researcher is able to achieve a consistent high-quality result.other applications.

        Our specialty chemicalsthird core competency is nucleic acid chemistries. Our synthetic nucleic acid products consist of nucleic acidchemical building blocks ("phosphoramidites"of nucleic acids (known as "phosphoramidites"), fluorescent markers and dyes, associated reagents, and oligomimetics. Oligomimeticssynthesized segments of nucleic acids (known as "oligonucleotides" and "oligomimetics"). These products are chemically-modified DNAused by research organizations, diagnostic companies and RNA molecules exhibiting proven enhancementspharmaceutical companies. We produce these products in stability, bioavailability, specificityour Glasgow, Scotland facility. We recently completed a new production facility in Boulder, Colorado that will be able to further process phosphoramidite products into synthesized oligonucleotides in larger quantities. This facility will also

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provide process development, enhancement and efficacy making them excellent candidates for use in clinical applicationsunique chemistry development services. Finally, our nucleic acid chemistry capabilities also include the ability to produce related specialty chemicals, such as genetic diagnosticsmolecular tags, dyes, quenchers, linkers, and therapeutics. Oligomimetics may also besolvents used in DNA diagnostics and chip technology.to modify nucleic acids for subsequent detection, or manipulation.

Business Strategy

        Our business strategy is to align our product and service offerings with the evolution of genetic advancements and to become a major supplier of products and services to researchers, medical institutions, diagnostic and pharmaceutical companies. Genetic advancements have been and continue to develop over time. The movement in the field of genomics, and related market opportunities, has shifted from gene discovery to the analysis of variations in gene sequences. From these variations researchers are beginning to link the impacts of variations in the gene sequences to disorders and diseases. It is hoped that this knowledge will lead to the creation of diagnostic tests for these disorders and diseases and the development of therapeutic treatments and drugs.

Research and Development

        We maintain an active program of research and development program. Our research and development work is focused on developing additional functionalityexpect to continue to spend significant amounts in the WAVE System that will allow us to sell additional applications other than those addressing genetic variation discovery.2003. Our research and development activities include the improvement of the DNA separation media used in our columns andWAVE System, the refinement of the hardware and software components of the WAVE System.System, the creation of unique enzymes and WAVE-optimized enzymes, and the improvement of chemical and biochemical reaction techniques for synthetic nucleic acids.

Sales and Marketing

        We arecurrently sell our products in major markets, including the U.S., U.K. and most countries in Western Europe, with a direct sales and support staff. For the rest of the world, we sell our products through dealers and distributors located in those local markets. As of June 30, 2003, we had over 25 dealers and distributors. We also developing improved methodsmaintain regionally-based technical support staffs and proceduresapplications scientists to enable researchers to usesupport our sales and marketing activities throughout the WAVE System to screen DNA samples for variations known to be related to genetic disease. We believe the

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WAVE System will be an attractive tool for this group of users because it will allow them to use the same validated methodology used to discover a variationU.S., Europe and its link to disease to screen for that variation in a large population. We are working to make the screening process faster and more automated through the development of new software and improved separation media and instrumentation.Japan.

Customers

        Since the product launch in August 1997 weWe have sold over 600 WAVE Systems in over 25 countriesour products to core laboratory facilities, academic research centers, medical institutions and biopharmaceutical companies. Customers that have purchased at least one WAVE System include Harvard University, Stanford University, Baylor College of Medicine, University of Chicago, Fred Hutchison Cancer Research Facility, Mayo Clinic, National Cancer Institute, National Institutes of Health, Institut Curie, University of Cambridge, Wellcome Trust-Oxford University, Institut Gustave Roussy, SmithKline Beecham, Bristol-Meyers Squibb, Millennium Pharmaceuticals, Merck & Company, Novartis and Eli Lilly and Company.

    Our specialty chemical products have over 600several hundred customers in over 20 countries and include many large pharmaceutical and biotechnology companies and academic research centers.30 countries. Customers include Abbott Laboratories, Affymetrix, AstraZenceca, Avecia, Fisher Scientific, Genset, Geron, Hitachi, Isis Pharmaceuticals, La Jolla Pharmaceuticals, Life Technologies, Lynx Therapeutics, MWG Biotech, Roche Biosciences, Ribozyme Pharmaceuticalsnumerous leading academic and SmithKline Beecham.medical institutions in the U.S. and abroad. In addition, our customers also include a number of large, established U.S. and foreign pharmaceutical, biotech and commercial companies.

Recent DevelopmentsManufacturing

        We acquired Annovis, Inc. effective May 1, 2001.manufacture bioconsumable products including our separation columns, liquid reagents, polymerase and nucleic acid products. The acquisition was structuredmajor components of our WAVE systems are manufactured for us by a third party. We integrate our own hardware and software with these third party manufactured components. Our manufacturing facilities for our WAVE systems and bioconsumables are located in Omaha, Nebraska, San Jose, California, and Cramlington, England. Our Synthetic Nucleic Acid products are manufactured in Glasgow, Scotland and Boulder, Colorado.

Intellectual Property

        To establish and protect our proprietary technologies and products, we rely on a combination of patent, copyright, trademark and trade-secret laws, as well as confidentiality provisions in our contracts. We have successfully prosecuted or licensed in numerous patents protecting our core technologies, and as a mergerresult we presently own rights to more than 80 issued patents and over 60 pending applications in

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both the US and abroad. We will continue to file patent applications and seek new licenses as we develop new products and technologies.

Recent Developments

        In 2002, we began a project to upgrade and expand our nucleic acid building block production capabilities in Glasgow, Scotland. This project included the upgrading of equipment and processes at the current production facility and the purchase of a new facility that will permit significant capacity expansion. The improvements to the existing production facility were completed during 2002 and the first production line, or pilot line, in the new facility was completed in 2003. Also in 2002, we leased a production facility in Boulder, Colorado and have been developing it as a cGMP (Good Manufacturing Practices) facility principally for the synthesis of oligonucleotides. The Boulder facility began limited cGMP production in the second quarter of 2003. While additional expansion projects for the Glasgow and Boulder production facilities may be undertaken over the next 2 to 3 years as business demand dictates, the current expansion projects have been substantially completed. As a result, our capital expenditures during the second half of 2003 are expected to be significantly lower than during the first six months of the year. Our original capital expenditures budget for 2003 was approximately $8.4 million. We have revised the budget downward. We now expect capital expenditures for the full year to be in the range of $6.2 million to $6.9 million.

        Since our inception, we have operated at a loss. In addition, we have used more cash than we generated from our operations due primarily to the expenditures we have needed to make for research and development, sales and marketing and expansion of our physical facilities. We instituted a cost reduction program beginning during the fourth quarter of 2002 in order to more closely align our cash expenditures with our current revenues and other cash resources. Among other things, this cost reduction program resulted in Annovis becomingthe elimination of a significant number of job positions during the first half of 2003 and the abandonment of certain intellectual property. We expect that, as a result of this restructuring, our wholly-owned subsidiary.total operating expenses for 2003 will be 20% to 25% below 2002 levels. Further restructuring activities may occur in the second half of 2003.

        During the third quarter of 2003 we began to pursue a sale/leaseback opportunity for our manufacturing facility in Glasgow, Scotland. Proceeds from this transaction are expected to be approximately $1.5 million, net of transaction costs and amounts used to repay our existing mortgage debt on the facility. We expect the transaction to close before December 31, 2003.

        On [                        ], 2003, we issued approximately 1.9 million4,500,000 shares of our common stock in a privately-negotiated sale to the selling stockholders listed in this Prospectus under the heading "Selling Stockholders." The sale of these shares was exempt from registration under the Securities Act of 1933, as amended (the "Securities Act") as a sale not involving a public offering. These shares were sold pursuant to the terms of a Securities Purchase Agreement, dated August 27, 2003, between the selling stockholders and paid approximately $600,000 in cash to acquire Annovis. A total of 15%us (the "Securities Purchase Agreement") which provided, among other things, that the sale of the shares was contingent only upon the staff of common stockthe Securities and Exchange Commission notifying us of its willingness to declare the Registration Statement relating to the resale of such shares by the selling stockholders (of which this Prospectus is a part) effective under the Securities Act. The number of shares and the purchase price for the shares was fixed at the time we issued inentered into the merger are held in an escrow account withSecurities Purchase Agreement. The net proceeds to us, after payment of a bank5% sales commission to Fahnestock & Co. Inc., who acted as our placement agent for the sale, and other expenses of the offering, were approximately $4,239,000, all of which will be deliveredused by us for working capital purposes. The shares issued by us to the former shareholdersselling stockholders under the Securities Purchase Agreement are the same shares being offered for resale by the selling stockholders under this Prospectus.

        Based upon our current projections, we expect to meet our cash needs for the remainder of Annovis upon satisfaction2003 from existing cash, additional cash generated from our working capital, additional funds available to us

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under our $5.0 million credit facility, the net proceeds of conditions described in the merger agreement. The sharesproposed sale/leaseback transaction and the proceeds of the sale of our common stock issued in connection withpursuant to the acquisition of Annovis, Inc.,Securities Purchase Agreement. These projections may or may not be realized based upon actual operating results and capital project requirements. Thus, cash generated by these sources may be sold pursuantinsufficient to this prospectus.

    On September 11, 2001, terrorists attacked locationssatisfy our liquidity requirements. We may need to sell additional equity or debt securities or obtain additional credit arrangements. We cannot assure you that any financing arrangement will be available in the United States. We have not yet fully analyzed the impact that these events may haveamounts or on terms acceptable to us. Our failure to raise additional capital, if needed, would harm our financial condition, results of operations and our business. Like other American businesses, it isWe are monitoring our liquidity position and are prepared to take appropriate measures, as needed, to address liquidity. Such measures include, but are not clear whether we will suffer any directlimited to, further expense reductions, an expansion of our line of credit, asset sales and the placement of equity or indirect impact from the attacks. We may be adversely impacted if these events cause a downturn in the global economy, disrupt shipping methods, change import and export controls, cause significant fluctuations in foreign currency exchange rates, delay purchasing decisions or have other negative effects which cannot now be anticipated.debt.

General Information

        We were incorporated in Delaware on March 6, 1997. Our principal office is located at 12325 Emmet Street, Omaha, Nebraska 68164 (telephone: 402-452-5400). We maintain manufacturing facilities in Omaha, Nebraska, Boulder, Colorado, San Jose, California, Aston, Pennsylvania, Glasgow, Scotland and Newcastle,Cramlington, England. We maintain research and development offices in Gaithersburg, Maryland, San Diego, California,Boulder, Colorado, Piscataway, New Jersey and Sheffield, England.Omaha, Nebraska.

        Our internet address iswww.transgenomic.com. We make our annual report on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and amendments to those reports available free of charge through our website is located at http:// www.transgenomic.com.as soon as reasonably practicable after we file these documents with the Securities and Exchange Commission. The information contained in our website is not part of this prospectus,Prospectus and you should not rely only on the information contained in this prospectusit in deciding whether to invest in our common stock.

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Shares to be Sold by Selling Stockholders


Common Stock offered by Selling Stockholders


4,773,699 shares (1)

Common Stock outstanding


23,186,901 shares (2)

(1)
Includes 105,870 shares issuable upon the exercise of outstanding options.

(2)
The number of shares outstanding does not include (i) 105,870 shares that will be issued upon the exercise of outstanding warrants or (ii) the shares that we could issue under our employee stock option plan. As the date of this prospectus, we have outstanding options to purchase 5,138,281 shares of common stock at exercise prices ranging from $5.00 to $13.00 per share. We may issue options to acquire up to 1,574,350 additional shares of our common stock under this plan.

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RISK FACTORS

        You should consider carefully the following risk factors and all other information contained in this prospectus before purchasing our common stock. InvestingAn investment in our common stock involves a high degreenumber of risk. Anyrisks. Before making an investment decision, you should carefully consider all of the following risks described in this Prospectus and the documents that are incorporated by reference into this Prospectus. The risks discussed in this Prospectus could harmmaterially adversely affect our business, financial condition and results of operations and could result in a complete losscause the trading price of our common stock to decline significantly. If this occurs, you may lose all or part of your investment.

Our limited operating history as a company focused on life sciences technologies and applications subjects us to risks inherent in the development of a new business enterprise and to the risk that we may not achieve profitability.

    We have a limited operating history as a company focused on life sciences technologies and applications and are at a relatively early stage of development in this business. Our future financial performance will depend on the growth in demand for automated DNA separation and analysis enabling technologies. The genomics market is new and emerging, is rapidly evolving, is characterized by an increasing number of market entrants, and will be subject to frequent and continuing changes in standards, customers' preferences and technology. As a result, our business is subject to all of the risks inherent in the development of a new business enterprise, such as the need:

    Our future operating results will depend on a number of factors, including the market acceptance of our products, the introduction of new products by our competitors, our ability to adapt our technology to the commercial needs of our customers and to developments in the genomics industry, and the timing and extent of our research and development efforts. Our limited operating history in the life sciences industry makes accurate prediction of future operations difficult.

We have a history of operating losses and expect to incur losses in the future.

        We have experienced losses from operations since inception of $2.8 million during the six months ended June 30, 2001, $8.7 million in fiscal 2000, $6.9 million in fiscal 1999 and $2.0 million in fiscal 1998.our operations. These losses were mostlyhave been due principally to the high levels of research and development expenses and sales and marketing expenses related to the development and marketing of our WAVE System. Inthat we have incurred in order to develop and market our products. In addition, markets for our products have developed more slowly than expected in some cases and may continue to enhance our WAVE System and related products, develop new products, increase the pace of installations and expand our marketing, sales and customer support service staffs,do so. As a result, we expect to incur increasesoperating losses in our expenses over the next several years. As a result, we could continue to incur losses for the foreseeable future and we may never be profitable.

Our technology and products are relatively new andWe may not gain market acceptance among genomics researchers.have adequate financial resources to execute our business plan.

        Our WAVE SystemWe have historically experienced operating losses and other automated DNA separation and analysis products are relatively new products. Market acceptance of our products is dependent upon factors, some of which are not in our control, such as continued growth in the genomics industry, the availability and price of competing products and technologies, the success of our sales efforts, and the acceptance of our product by the academic and research community, such as biologists, geneticists and biochemists, who are more familiar with the existing, traditional methods of DNA separation and analysis. Our products must compete against well-established techniques, such as gel and capillary electrophoresis and sequencing-based technologies. We cannot be certain that our products will replace or compete successfully against

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existing products or that our products will achieve market acceptance. If our products do not achieve market acceptance, we may not achieve profitability.

If ethical and other concerns surrounding the use of genetic information become widespread, we may have less demand for our products.

    Genetic testing has raised ethical issues regarding confidentiality and the appropriate uses of the resulting information. For these reasons, governmental authorities may call for limits on or regulation of the use of genetic testing or prohibit testing for genetic predisposition to disease, particularly for those that have no known cure. Any of these scenarios could reduce the potential markets for our products, which could limit our future revenues.

The sale of our products involves a lengthy sales cycle that makes our revenues difficult to forecast.

    Our ability to obtain customers for our WAVE System and related accessories depends in large part on the perception that our products can help accelerate basic genomics research, diagnostic testing and related applications such as drug discovery and development efforts. A WAVE System sells for between $60,000 to $100,000 depending on its features and accessories. For many potential customers, who are often constrained by limited research budgets, this will be a large capital outlay. Additionally, the sales cycle is often three to six months long due to the need to educate potential customers as to the benefits and use of our WAVE System. We also need to effectively communicate the benefits of our WAVE System to a variety of constituencies within potential customer groups, including research and development personnel and key management. We may expend substantial funds and sales effort with no assurance that a sale will result. Due to the lengthy sales cycle required, our revenues could be difficult to forecast.

Should our future business plans dictate a need to raise additional funding, such funding may not be available.

negative cash flows. To date, we have financed our operations and capital expenditures primarily from the net proceeds of a $69.9$77.3 million public offering of common stock,stock. Additionally, in June 2003 we entered into a $10.0loan agreement with a financial institution for up to a $5 million private offering of common stock, a $12.0 million issuance of convertible notes and borrowings under our former $5.0 million banksecured line of credit. Although we willWe expect to continue to need substantial amounts of cash to fund our operations and capital expenditures in the future. Based upon our current projections, we expect to meet our cash needs for researchthe remainder of 2003 from existing cash, additional cash generated from our working capital, additional funds available to us under our $5.0 million credit facility, the net proceeds of the proposed sale/leaseback transaction and development, the expansionproceeds of a private placement of 4.5 million shares of our salescommon stock. These projections may or may not be realized based upon actual operating results and marketing infrastructure and for our capital and operating expenses, we currently anticipate thatproject requirements. Thus, our existing cash balances, cash generated by our working capital, available borrowings under credit agreements, net proceeds of the proposed sale/leaseback transaction and investment balances are sufficientproceeds of the private placement may be insufficient to financesatisfy our existing business plan. If we revise our business planliquidity requirements. Accordingly, we may need to raise additional capital. The amount of additional capital that we may need to raise will depend on many factors, including:


    We may need to raise the additional capital in the future through bankfuture. However, we cannot assure you that additional financing or strategic investments. Additional financing may notwill be available to us when we need it or if available, we cannot assure that we will be able to obtain such financing on terms favorable to our stockholders or us.acceptable terms. If we raise additional capital by issuing common stock or other equity securities, the issuance of suchthese securities would result in ownership dilution of our existing stockholders. If we borrow additional money, we will incur additional interest costs and may become subject to covenants that restrict our stockholders.

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Our WAVE System includes hardware components and instruments manufactured by a single supplier and ifoperations. If we were no longerare not able to obtain these componentsadditional capital as needed, we may need to take further steps to reduce our operating costs, and instrumentsmay not be able to execute parts or all of our ability to manufacturebusiness plan.

Markets for our products could be impaired.and services may develop slowly.

        We currently rely on a single supplier, Hitachi Instruments, Inc., to provideThere are many factors that affect the basic instrument usedmarket demand for our products and services that we cannot control. This is especially true in our WAVE System. While other suppliers of instrumentation and computer hardware are available, we believe that our arrangement with Hitachi offers strategic advantages. If we were required to seek alternative sources of supply, it could be time consuming or expensive or require significant and costly modification of our WAVE System. Also, if we were unable to obtain instruments from Hitachi in sufficient quantities or in a timely manner, our ability to manufactureNucleic Acid segment where the demand for our products could be impaired, which could limit our future revenues.

Our chromatographic columns,depends to a core component oflarge degree on the WAVE System, are manufactured at a single facilitysuccess that is located in an earthquake-prone area.

    All of our proprietary DNASep, OLIGOSep and RNASep columns are manufactured at our manufacturing facility in San Jose, California, which is located in an earthquake-prone area. In the event our manufacturing facility or equipment was affected by man-made or natural disasters, we would be unable to manufacture our products for sale or meet customer demand or sales projections. If our manufacturing operations were curtailed or ceased for any significant period of time, it could limit our future revenues.

We face, and will continue to face, intense competition, both in the U.S. and abroad, from companies that are engaged in the development of products that analyze DNA and provide genetic information.

    The nucleic acid analysis and separations markets are highly competitive. Our principal competitors include other biotechnology companies that provide alternative technologies and products for the separation and analysis of DNA. Many of our competitors have greater financial, operational, sales and marketing resources and more experience in research and development and commercialization than we have. Moreover, some of our competitors have greater name recognition than we do and provide more conventional technologies and products with which some of our customers and potential customers have in developing useful pharmaceutical products based on genetic intervention. A central strategy for our Nucleic Acid segment is to sell synthetic nucleic acid products to biopharmaceutical and pharmaceutical companies that are seeking to develop commercially viable genomic-based diagnostic and therapeutic products. We have invested a significant amount of capital into acquiring and developing manufacturing facilities and other assets to allow us to pursue this market. However, this is a new field of commercial development, and many of these biopharmaceutical and pharmaceutical companies are in the early stages of their efforts to develop genomic-based diagnostics and therapeutics, and have encountered difficulties in these efforts. As a result, the demand for our synthetic nucleic acid products is difficult to forecast and may have more familiaritydevelop slowly or experience.sporadically. In orderaddition, we cannot assure you that these companies will not develop internally the chemistries and manufacturing capabilities to effectively compete against alternative technologiesproduce the

5



products they could buy from us. Demand for our WAVE System is similarly affected by the needs and budgetary resources of research institutions, universities, hospitals and others who use the WAVE System for genetic-variation research. The WAVE System represents a significant expenditure by these types of customers and often requires a long sales cycle. If revenues from the sales of our products and services continue at current levels, we willmay need to demonstrate the superior performance, speed, capabilities and cost effectiveness of our WAVE System.

    Extensive research efforts and rapid technological progress characterize the genomics industry. To remain competitive,raise additional working capital or take steps to further reduce operating expenses. We cannot assure you that sales will increase or that we will be requiredable to continue to expand and enhance the functionalityraise additional working capital or reduce operating expenses.

The sale of our DNA separationproducts and analysis equipmentbusiness operations in international markets subjects us to additional risks.

        International sales have historically accounted for approximately 50% of our net sales. As a result, a major portion of our revenues and expenses are subject to offer comprehensive DNA analysis,risks associated with international sales and complimentary applications and solutions, with greater ease of use. This will include the need to increase the WAVE System's capacity and to develop new instrumentation, software and application kits to allow the system to provide a broader range of DNA and RNA separation and analysis applications. New products may require additional development work, enhancement, testing, or further refinement before they can be made commercially available and, therefore, we could experience significant delaysoperations. These risks include:

    payment cycles in foreign markets are typically longer than in the developmentU.S.;

    changes in foreign currency exchange rates can make our products more costly and manufacture ofoperating expenses higher in local currencies since our products. Even after newforeign sales and operating expenses are typically paid for in U.S. Dollars, British Pounds or the Euro; and

    the potential for changes in U.S. and foreign laws or regulations that result in additional import or export restrictions, higher tariffs or other taxes, more burdensome licensing requirements or similar impediments to our ability to sell products are made commercially available, unforeseen technical difficulties could arise, requiring additional expenditures by us to correct such difficulties and possibly resultingservices profitably in further delays. We cannot be certain that new products will be successfully developed at all.

    these markets.

Our patentsWe may not protect ushave adequate personnel to execute our business plan.

        During the fourth quarter of 2002 and the first quarter of 2003, we took steps to reduce our operating costs that resulted in a significant reduction in the number of employees, including our research and development staff and our sales and marketing personnel. In addition, we may lose other key management, scientific, technical, sales and manufacturing personnel from others using our technology whichtime to time. It may be very difficult to replace personnel if they are needed in the future, and the loss of key personnel could harm our business and operating results. We cannot assure you that our employee reductions will not impair our ability to continue to develop new products and refine existing products in order to remain competitive. In addition, these reductions could prevent us from successfully marketing our products and developing our customer base.

Our markets are very competitive.

        We compete with many other companies in both our Biosystems segment and Nucleic Acids segment. Competitors for our Biosystems segment include several companies, such as Varian, Waters, Agilent, Applied Biosystems, Beckman Coulter, Amersham Biosciences and Invitrogen. These companies provide various products and services that compete either directly with our WAVE system, bioconsumables and services, or indirectly through alternative technologies and/or methods. Competitors for our Nucleic Acid segment vary depending on the product. In the standard chemical building blocks market, we compete with Applied Biosystems, Proligo and Pierce Nucleic Acid Technologies. The competitors for our pharmaceutical-grade oligonucleotide synthesis products and services include primarily Proligo, Dow Chemical and Avecia. Many of these competing companies have greater resources than we do or may enjoy other competitive position.advantages. This may allow them to more effectively market their products to our customers or potential customers, to develop products that make our products obsolete or to produce and sell products less expensively than us. As a result of these competitive factors, demand for, and pricing of, our products and services could be negatively affected.

6



The price for our common stock is volatile and may drop further.

        Our businessstock has traded at prices as high as $30.00 per share immediately after our initial public offering in 2000 to as low as $0.93 per share in April 2003. This volatility in the price of our stock is attributable to a number of factors, not all of which relate to our operating results and competitive position are dependent uponfinancial position. Nevertheless, continued volatility in the market price for our stock should be expected and we cannot assure you that the price of our stock will increase in the future. Fluctuations or further declines in the price of our stock may affect your ability to sell shares of our stock and our ability to raise capital through future equity financing.

Our intellectual property rights may not always protect our proprietary technology. While we currently hold a number of domestic and foreign patents and licenses, the

8


issuance of a patent is not conclusive as to its validity or enforceability, nor does it provide the patent holder with freedom to operate without infringing the patent rights of others. Our patents or licenses could be challenged by litigation and, if the outcome of such litigation were adverse to us, our competitors could be free to use our technology. As a result, the invalidation of key patents owned by or licensed to us or non-approval of pending patent applications could increase competition for our products. We may not be able to obtain additional patents for our technology, or if we are able to do so, patents may not provide us with substantial protection or be commercially beneficial. Our patent applications may not protect our products because of the following reasons:

    we cannot be certain that any of our pending patent applications will result in additional issued patents;

    we may develop additional proprietary technologies that are not patentable;

    we cannot be certain that any patents issued or licensed to us will provide a basis for commercially viable products;

    we cannot be certain that any patents issued or licensed to us will not be challenged or circumvented or invalidated by third parties; and

    we cannot be certain that any patents issued to others will not have an adverse effect on our ability to do business.

    Patent law relating to the scope of claims in the technology fields in which we operate is still evolving. The degree of future protection for our proprietary rights is uncertain. Furthermore, we cannot be certain that others will not independently develop similar or alternative products or technology, duplicate any of our products, or, if patents are issued to us, design around the patented products developed by us. In addition, we could incur substantial costs in litigation if we are required to defend ourselves in patent suits brought by third parties or if we initiate such suits.

We cannot be certain that other measures taken to protect our intellectual property will be effective.

        We rely upon trade secreton our patents and license agreements to protect our right to produce and sell our proprietary technologies. However, we cannot assure you that these patents and licenses will always provide us with meaningful protection copyright and trademark laws, non-disclosure agreements and other contractual provisions for somefrom competitors. Even if a competitor's product infringes one of our confidentialpatents, it will be costly and proprietary informationtime consuming to enforce the patent in court, and there can be no assurance that is not subject matter for which patent protection is being sought. Such measures, however, may not provide adequate protection for our trade secrets or other proprietary information. If theysuch an action will be successful. In addition, many foreign countries do not protect our rights, third parties could use our technologypatents and our ability to compete in the market would be reduced. While we require employees, academic collaborators and consultants to enter into confidentiality agreements and/or intellectual property assignments where appropriate, any of the following could still occur:

    proprietary information could be disclosed or others may gain access to such information;

    others may independently develop substantially equivalent proprietary information and techniques;

    we may not have adequate remedies for any breach; or

    we may not be able to meaningfully protect our trade secrets.

We are dependent upon our licensed technologies and may need to obtain additional licenses in the future to offer our products and remain competitive.

    We have acquired or licensed key components of our technologies from third parties. If these agreements were to terminate prematurely or if we breach the terms of any licenses or otherwise fail to maintain our rights to such technology, we may lose the right to manufacture or sell our products. In addition, we may need to obtain licenses to additional technologies in the future in order to keep our

9


products competitive. If we fail to license or otherwise acquire necessary technologies, we may not be able to develop new products that we need to remain competitive.

The protection of intellectual property in foreign countries is uncertain.

    We have sold approximately 50% of our WAVE Systems to customers located outside the U.S. The patent and other intellectual property laws of some foreign countries may not protect our intellectual property rights to the same extent as U.S. laws. Wethe United States. Therefore, we may need to bring proceedings to defendencounter difficulties in protecting our patent rights or to determine the validity of our competitors' foreign patents. These proceedings could result in substantial cost and diversion of our efforts. Finally, some of our patent protection in the U.S. is not available to uspatented technology in foreign countries duewhere we market our products. With respect to the laws of those countries.

Our products could infringe on the intellectual property rights of others which could require us to pay substantial royalties.

    There are a significant number of U.S. and foreign patents and patent applications submitted for technologies in, or related to, our area of business. As a result, any application or exploitation of our technology could infringe patents or proprietary rights of others and any licenses that we might need as a result of such infringement might nothave pursuant to license agreements, we cannot assure you that in all cases the licensors will be availablewilling to continue to grant us on commercially reasonable terms,these licenses or, if at all. This may lead others to assert patent infringement or other intellectual property claims against us. We may have to pay substantial damages, including treble damages, for past infringement if it is ultimately determined that our products infringe on another party's intellectual property rights. We could also be prohibited from selling our products before we obtain a license, which, if available at all, may require us to pay substantial royalties. Even if a claim is without merit, defending a lawsuit takes significant time, may be expensive and may divert management attention from other business concerns.

We depend on attracting and retaining key employees.

    Wethey are highly dependent on the principal members of our management staff and research and development group, including Collin J. D'Silva, our Chief Executive Officer. We have entered into employment agreements with Mr. D'Silva and some, but not all, of our other key employees. The loss of services of any of these individuals could seriously harm our product development and commercialization efforts for our new life sciences products. Our future success will also depend on our ability to attract, hire and retain additional personnel, including sales and marketing personnel, technical support and customer service staff and application scientists. There is intense competition for qualified personnel in our industry, especially for experienced personnel in the areas of chemistry and molecular biology, software and electrical engineering, manufacturing and marketing, and there can be no assurancecontinued, that we will be able to continueobtain favorable licensing and/or royalty terms. In addition to attractpatents and retain such personnel. Failurelicenses, we rely on unpatented trade secrets that we seek to attract and retain key personnel could reduceprotect with confidentiality agreements. However, if these agreements are breached, or if our abilitytrade secrets become known or are developed independently, we may not be able to continue developmentadequately protect these trade secrets. Finally, we cannot be certain that our products or processes will not be found to infringe on the patents or other intellectual property rights of our DNA separation and analysis technology and to successfully market our products.

We will need to effectively manage our growth ifothers. If we are found to successfully implement our strategy.

    The numberbe infringing on other's intellectual property rights, we may not be able to obtain a license from the owner of employees and scope of our business operations are expected to grow as we continue the commercialization of our WAVE System. This growth may place a strainintellectual property on our management and operations. Our ability to manage our growth will depend on the ability of our officers and key employees to continue to implement and improve our operational, management information and financial control systems and to expand, train and manage our work force both in the U.S. and abroad. We may be required to open non-U.S. offices in addition to our current U.K., Japan and satellite European offices, which could result in additional burdens on our systems and resources. Our inability to manage our growth effectively could affect our ability to pursue business opportunities and expand our business.

10


Our failure to comply with any applicable government regulationscommercially reasonable terms or otherwise respond to claims relating to improper handling, storage or disposal of hazardous chemicals which we use may adversely affect our results of operations.

    Our research and development and manufacturing activities involve the controlled use of hazardous materials and chemicals, including acetonitrile. We are subject to federal, state and local laws and regulations governing the use, storage, handling and disposal of hazardous materials and waste products. If we fail to comply with applicable laws or regulations, we could be required to pay penalties or be held liable for any damages that result and this liability could exceed our financial resources. We cannot assure you that accidental contamination or injury will not occur. Any such accident could damage our research and manufacturing facilities and operations, resulting in delays and increased costs.at all.


FORWARD-LOOKING STATEMENTSUSE OF PROCEEDS

        We have made forward-looking statements inwill not receive any proceeds from the sale of the shares of common stock offered by this prospectus andProspectus. We received net proceeds of approximately $4.2 million pursuant to the documents that are incorporatedSecurities Purchase Agreement entered into this prospectus by reference, see "Incorporation of Certain Documents by Reference".with the selling stockholders. These statements are subject to risks and uncertainties. Many of these forward-looking statements refer to our plans, objectives, expectations and intentions, as well as our future financial results. You can identify these forward-looking statements by forward-looking words such as "expects," "anticipates," "intends," "plans," "may," "will," "believes," "seeks," "estimates" and similar expressions. Because these forward-looking statements involve risks and uncertainties, there are important factors that could cause our actual results to differ materially from those expressed or implied by these forward-looking statements, including our plans, objectives, expectations and intentions and other factors discussed under "Risks Related to Our Business" and other factors identified by cautionary languageproceeds will be used elsewhere in this prospectus and the incorporated documents.

11


for working capital purposes.


SELLING STOCKHOLDERS

        The shares offered by this Prospectus may be sold from time to time by the selling stockholders named in the following table shows thetable. The number of shares beneficially owned by each of thethese selling stockholders. This prospectus also relatesstockholders are offering under this Prospectus will be adjusted to reflect any additional shares of common stock which may become issuable to the selling stockholders by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration and which results in an increase in the number of our outstanding shares of common stock.

        The following table also sets forth the total number of shares offeredof our common stock beneficially owned by this prospectus may be offered from time to time by the selling stockholders. A total of 294,522 shares issued in connection with the acquisition of Annovis, Inc. will be held in escrow until May 29, 2002. Such shares may not be sold until they are released from escrow.

    A numbereach of the selling stockholders are non-officer employeesand the percentage of Transgenomic. No otherour total outstanding shares of common stock that each selling stockholder holds any position or office with Transgenomic or has any other material relationship with us.

beneficially owns. Percentage ownership is based on the 23,186,90128,008,839 shares of our common stock outstanding as of August 24, 2001.the date of this Prospectus. For purposes of computing the percentage of outstanding shares held by each person or group of persons named below,selling stockholder, any security which such person or group of personscommon stock that a selling stockholder has thea right to acquire, pursuant to an option, warrant or other agreement, within 60 days isof the date of this Prospectus has been deemed to be outstanding for the purpose of

7



computing the percentage ownership for such person or persons, but is not deemed to be outstanding for the purpose of computing the percentage ownership of any other person. The estimate of shares owned after this offering assumes that all shares offered by the prospectusProspectus are sold. These estimates may prove to be inaccurate because the selling stockholders may offer all or some of their shares and because there currently are no agreements, arrangements or understandings with respect to the sale of any of the shares.

 
 Shares Beneficially Owned Prior to the Offering
  
 Shares Beneficially Owned After the Offering
Name

 Shares to be Sold
 Number
 Percentage
 Number
 Percentage
Consolidated Investment Corp. 33,613 * 33,613 0 *
Max H. Callen 5,891 * 5,891 0 *
Eames Irvin 4,071 * 471 3,600 *
Allen J. Moore 3,417 * 3,417 0 *
George W. Peterson 8,601 * 8,601 0 *
William B. Shreve Trust 11,246 * 2,946 8,300 *
Thomas C. Smith 63,420 * 47,420 16,000 *
A. John Walters 9,691 * 5,891 3,800 *
John P. Kanouff 16,850 * 16,850 0 *
Robert H. Taggart 3,370 * 3,370 0 *
James M. McCrory 500 * 500 0 *
Leroy J. Schroeder 2,500 * 2,500 0 *
Michael R. Fugler 800 * 800 0 *
David M. Dobson 500 * 500 0 *
Frank T. Marino 500 * 500 0 *
Chancellor Private Capital Partners III, L.P. 260,649 1.1% 260,649 0 *
Citiventure 96 Partnership L.P. 1,118,934 4.8% 1,118,934 0 *
Chancellor Private Capital Offshore Partners II, L.P. 429,142 1.8% 429,142 0 *
Chancellor Private Capital Offshore Partners I, C.V. 40,117 * 40,117 0 *

12


Drake & Co. for the account of Citiventure III 443,584 1.9% 443,584 0 *
Berkely Investments Limited 126,083 * 126,083 0 *
Daystar Realty Limited 57,310 * 57,310 0 *
Hambrecht & Quist California 27,509 * 27,509 0 *
Hambrecht & Quist Employee Venture Fund, L.P. II 27,509 * 27,509 0 *
CLSP, L.P. 135,253 * 135,253 0 *
CLSP/SBS I, L.P. 50,433 * 50,433 0 *
CLSP/SBS II, L.P. 20,631 * 20,631 0 *
Steve Elms 2,292 * 2,292 0 *
John Rumsey 2,292 * 2,292 0 *
Rob Olan 2,292 * 2,292 0 *
Vivek Jain 2,292 * 2,292 0 *
Dennis Purcell 2,292 * 2,292 0 *
George Montgomery 2,292 * 2,292 0 *
3i PLC 13,976 * 13,976 0 *
John Bremner 2,281 * 2,281 0 *
Dunedin Enterprise Investment Trust PLC 35,677 * 35,677 0 *
Euclid Partners III, L.P. 231,396 1.0% 231,396 0 *
Anthony Giordano 1,515 * 1,515 0 *
Morton Goldberg 405 * 405 0 *
Grotech III Companion Fund, L.P. 2,007 * 2,007 0 *
Grotech III Pennsylvania Fund, L.P. 1,149 * 1,149 0 *
Grotech Partners III, L.P. 18,414 * 18,414 0 *
Joseph Hall 28,483 * 28,483 0 *
Brendan Hamil 4,305 * 4,305 0 *
David Jacobs 135 * 135 0 *
Urbanex Co., Ltd. 28,409 * 28,409 0 *
Michael Lewis 539 * 539 0 *
Maria Maccecchini 158,229 * 108,229 50,000 *
Hugh Mackie 1,865 * 1,865 0 *
Personal Assets Investments Limited 9,457 * 9,457 0 *
Douglas Picken 2,176 * 2,176 0 *
Saul Cherkofsky & Marjorie Cherkofsky TR UA 11/3/94 Saul C. Cherkofsky Trust 768 * 768 0 *
Jill M. Roberts-Lewis 135 * 135 0 *
S.R. One, International BV 21,344 * 21,344 0 *
S.R. One, Limited 1,108,133 4.8% 1,108,133 0 *
S.R. One Limited UK 118,210 * 118,210 0 *
Scottish Enterprise 21,819 * 21,819 0 *
Sowa Trading Co. Inc. 26,269 * 26,269 0 *
Trustees of the University of Pennsylvania 20,714 * 20,714 0 *
David Weiner 216 * 216 0 *

13


Ian Wilkie 28,484 * 28,484 0 *
John Ackroyd 5,303 * 5,303 0 *
Heinrich Betz 276 * 276 0 *
Frank Black 751 * 751 0 *
Patrick Owen Burns 3,535 * 3,535 0 *
Elizabeth Byerley 44 * 44 0 *
William Catterall 884 * 884 0 *
John Barklie Clements 442 * 442 0 *
Joseph Coyle 368 * 368 0 *
Gordon Duckworth 530 * 530 0 *
Edward Ferry 608 * 608 0 *
Robert Forbes 840 * 840 0 *
Michael Galdzicki 809 * 809 0 *
Bruce Galton 23,435 * 3,435 20,000 *
Ramon Garcia 37 * 37 0 *
Krishakali Ghosh 5,745 * 5,745 0 *
Elizabeth Haley 133 * 133 0 *
Sidney Hecht 14,564 * 14,564 0 *
Frances Hendren 133 * 133 0 *
Yeng Him 117 * 117 0 *
Anne Hoeck 221 * 221 0 *
Linda Hoeck 972 * 972 0 *
Gary Keaveney 221 * 221 0 *
Angelina Kline-Burgess 10 * 10 0 *
Angus Iain Lamond 552 * 552 0 *
Kenneth Mcfarlane 618 * 618 0 *
Gerald Martin 618 * 618 0 *
Edward McCrindle 177 * 177 0 *
Michelle McGready 398 * 398 0 *
Karen McKinnon 89 * 89 0 *
Emma Miller 89 * 89 0 *
Robert Molinari 539 * 539 0 *
David Nicolson 221 * 221 0 *
Michael O'Kane 707 * 707 0 *
Laszlo Otvos 884 * 884 0 *
Brian Paine & Jennifer Kennedy Paine JT TEN 6 * 6 0 *
Xue-Feng Pei 558 * 558 0 *
Colin Reese 552 * 552 0 *
Kenner Rice 405 * 405 0 *
David Rodger 486 * 486 0 *
Francis J. Schmidt & Sharon Stevens JT TEN 552 * 552 0 *
Peter Sears 10,249 * 249 10,000 *
David Vincent 221 * 221 0 *
Douglas Walker 618 * 618 0 *
Eileen Welsh 133 * 133 0 *

14


Paul West 133 * 133 0 *
Allison Wylie 133 * 133 0 *
Logan Young 972 * 972 0 *
Pei-Zhuo Zhang 618 * 618 0 *
TLP Leasing Programs, Inc. 500 * 500 0 *
Silicon Valley Bank 2,000 * 2,000 0 *
Brenda K. Stroup 7 * 7 0 *
 
 Shares Beneficially Owned Prior to the Offering
  
 Shares Beneficially Owned After the Offering
 
Name
 Number
 Percentage
 Shares
to be Sold

 Number
 Percentage
 
Kopp Emerging Growth Fund 2,800,000 9.98%2,050,000 750,000 2.67%

Advisors Fund for Employees Benefit Trust

 

66,100

 

*

 

37,300

 

28,800

 

*

 

The Collins Foundation

 

3,650

 

*

 

2,100

 

1,550

 

*

 

Daughter's of Charity Fund—P

 

152,300

 

*

 

85,800

 

66,500

 

*

 

East Bay Municipal Utility District

 

50,300

 

*

 

28,400

 

21,900

 

*

 

Hendrix College

 

14,200

 

*

 

8,000

 

6,200

 

*

 

Horace Mann Small Cap Growth Fund

 

57,200

 

*

 

32,300

 

24,900

 

*

 

Intermountain Health Care

 

58,500

 

*

 

33,000

 

25,500

 

*

 

Kansas City Firefighters Retirement System

 

37,000

 

*

 

20,900

 

16,100

 

*

 

Los Angeles County Employee Retirement Association

 

658,013

 

2.35

%

371,400

 

286,613

 

1.02

%

Marin County Employee Retirement System

 

122,600

 

*

 

69,100

 

53,500

 

*

 

Mass Mutual Small Company Growth Fund

 

113,600

 

*

 

65,100

 

48,500

 

*

 

Northwest Airlines—DB

 

260,700

 

*

 

147,100

 

113,600

 

*

 

Northwest Airlines—DC

 

303,600

 

1.08

%

171,400

 

132,200

 

*

 

City of New York Police Pension Fund

 

207,000

 

*

 

116,700

 

90,300

 

*

 

Operf

 

60,800

 

*

 

34,300

 

26,500

 

*

 

Portland General Electric

 

38,300

 

*

 

21,600

 

16,700

 

*

 

Les Schwab Tires

 

59,400

 

*

 

33,500

 

25,900

 

*

 

SEI Institutional Investments Trust

 

457,600

 

1.63

%

258,200

 

199,400

 

*

 

SEI Institutional Managed Trust

 

613,200

 

2.19

%

346,000

 

267,200

 

*

 

University of Miami Growth Plan

 

97,300

 

*

 

54,900

 

42,400

 

*

 

Retirement Plan for University of Miami

 

54,800

 

*

 

33,300

 

21,500

 

*

 

Undiscovered Managers Small Cap Growth Fund

 

261,100

 

*

 

149,000

 

112,100

 

*

 

Utah Retirement Systems

 

360,600

 

1.29

%

203,400

 

157,200

 

*

 

Horizon Rudder & Co.

 

135,500

 

*

 

77,200

 

58,300

 

*

 

Frank Colen

 

25,000

 

*

 

25,000

 

0

 

*

 

Edward Newman

 

12,500

 

*

 

12,500

 

0

 

*

 

James Irvine

 

13,500

 

*

 

12,500

 

1,000

 

*

 

*
less than 1%

158



PLAN OF DISTRIBUTION

        The selling stockholders or their donees or pledgees may sell their shares of our common stock from time to time. The selling stockholders will act independently of us in making decisions regarding the timing, manner and size of each sale. The sales may be made on the Nasdaq National Market, or in the over-the-counter market or otherwise, at prices and at terms then prevailing or at prices related to the then current market price, or in negotiated transactions. The last reported sale price of our common stock on August 27, 2003 was $1.14 per share. The selling stockholders may effect such transactions by selling the shares to or through broker-dealers. The shares may be sold by one or more of, or a combination of, the following:

    a block trade in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction,

    purchases by a broker-dealer as principal and resale by such broker-dealer for its account under this prospectus,

    an exchange distribution in accordance with the rules of such exchange,

    ordinary brokerage transactions and transactions in which the broker solicits purchasers, and

    in privately negotiated transactions.

        To the extent required, this prospectusProspectus may be amended or supplemented from time to time to describe a specific plan of distribution. In effecting sales, broker-dealers engaged by the selling stockholders may arrange for other broker-dealers to participate in the resales. The selling stockholders may enter into hedging transactions with broker-dealers in connection with distributions of the shares or otherwise. In these transactions, broker-dealers may engage in short sales of the shares in the course of hedging the positions they assume with selling stockholders. The selling stockholders also may sell shares short and redeliver the shares to close out such short positions. The selling stockholders may enter into option or other transactions with broker-dealers which require the delivery to the broker-dealer of the shares. The broker-dealer may then resell or otherwise transfer such shares under this prospectus. The selling stockholders also may lend or pledge their shares to a broker-dealer. The broker-dealer may sell the shares so lent, or upon a default the broker-dealer may sell the pledged shares under this prospectus.Prospectus.

        Broker-dealers or agents may receive compensation in the form of commissions, discounts or concessions from selling stockholders. Broker-dealers or agents may also receive compensation from the purchasers of the shares for whom they act as agents or to whom they sell as principals, or both. Compensation as to a particular broker-dealer might be in excess of customary commissions and will be in amounts to be negotiated in connection with the sale. Broker-dealers or agents and any other participating broker-dealers or the selling stockholders may be deemed to be "underwriters" within the meaning of Section 2(11) of the Securities Act of 1933 (the "Securities Act") in connection with sales of the shares. Accordingly, any such commission, discount or concession received by them and any profit on the resale of the shares purchased by them may be deemed to be underwriting discounts or commissions under the Securities Act. Because selling stockholders may be deemed to be "underwriters" within the meaning of Section 2(11) of the Securities Act, the selling stockholders will be subject to the prospectus delivery requirements of the Securities Act. In addition, any securities covered by this prospectusProspectus which qualify for sale under Rule 144 promulgated under the Securities Act may be sold under Rule 144 rather than under this prospectus.Prospectus. The selling stockholders have advised us that they have not entered into any agreements, understandings or arrangements with any underwriters or broker-dealers regarding the sale of their securities. There is no underwriter or coordinating broker acting in connection with the proposed sale of shares by the selling stockholders.

9



        The shares will be sold only through registered or licensed brokers or dealers if required under applicable state securities laws. In addition, in certain states the shares may not be sold unless they

16


have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with.

        Under applicable rules and regulations under the Securities Exchange Act of 1934 (the "Exchange Act"), any person engaged in the distribution of the shares may not simultaneously engage in market making activities with respect to our common stock for a period of two business days prior to the commencement of such distribution. In addition, each selling stockholder will be subject to applicable provisions of the Exchange Act and the associated rules and regulations under the Exchange Act, including Regulation M, which provisions may limit the timing of purchases and sales of shares of our common stock by the selling stockholders. We will make copies of this prospectusProspectus available to the selling stockholders and have informed them of the need to deliver copies of this prospectusProspectus to purchasers at or prior to the time of any sale of the shares.

        We will file a supplement to this prospectus,Prospectus, if required, to comply with Rule 424(b) under the Securities Act upon being notified by a selling stockholder that any material arrangements have been entered into with a broker-dealer for the sale of shares through a block trade, special offering, exchange distribution or secondary distribution or a purchase by a broker or dealer. Such supplement will disclose:

    the name of each such selling stockholder and of the participating broker-dealer(s),

    the number of shares involved,

    the price at which such shares were sold,

    the commissions paid or discounts or concessions allowed to such broker-dealer(s), where applicable,

    that such broker-dealer(s) did not conduct any investigation to verify the information set out or incorporated by reference in this prospectus, and

    other facts material to the transaction.

        In addition, upon being notified by a selling stockholder that a donee or pledgee intends to sell more than 500 shares, we will file a supplement to this prospectus.Prospectus.

        We will bear all costs, expenses and fees in connection with the registration of the shares. We agreed to indemnify and hold the selling stockholders harmless against certain liabilities under the Securities Act that could arise in connection with the sale by the selling stockholders of the shares. The selling stockholders will bear all commissions and discounts, if any, attributable to the sales of the shares. The selling stockholders may agree to indemnify any broker-dealer or agent that participates in transactions involving sales of the shares against certain liabilities, including liabilities arising under the Securities Act.


LEGAL MATTERS

    The validity of the common stock offered by this prospectus will be passed upon for us by Kutak Rock LLP, Omaha, Nebraska.


EXPERTS

        The financial statements as of December 31, 2002 and 2001 and for each of the three years in the period ended December 31, 2002 incorporated in this prospectusProspectus by reference from the Company'sour Annual Report on Form 10-K for the year ended December 31, 20002002 have been audited by Deloitte & Touche LLP, independent auditors, as stated in their report (which report expresses an unqualified opinion and includes an explanatory paragraph relating to our change in method of accounting for goodwill and other intangible assets in connection with the adoption of Statement of Financial Accounting Standards No. 142,Goodwill and Other Intangible Assets, in 2002 and our receipt of a commitment letter for a new revolving credit agreement on March 31, 2003), which is incorporated herein by reference, and has

10



been so incorporated, in reliance upon the report of such firm given upon their authority as experts in accounting and auditing.

17



LEGAL OPINIONS

        The validity of the common stock offered by this Prospectus has been passed upon for us by Kutak Rock LLP, Omaha, Nebraska.


WHERE YOU CAN FIND MORE INFORMATION

        We file annual, quarterly and special reports, proxy statements and other information with the Securities and Exchange Commission.Commission (the "SEC"). You may read and copy the materials we file at the Commission'sSEC's Public Reference Room at 450 Fifth Street, N.W., Washington, D.C. 20549, andas well as at the followingSEC's regional offices of the Commission: Seven World Trade Center, Room 1400, New York, New York 10048 andoffice at Citicorp Center, 500 West Madison Street, SuiteRoom 1400, Chicago, Illinois 60661. Copies of such materials can be obtained from the Public Reference Section of60661-2511. Please call the Commission at 450 Fifth Street, N.W., Washington, D.C. 20549, Room 1024, at prescribed rates. The public may obtain1-800-SEC-0330 for further information on the operation of the Public Reference Room by callingRooms. Our SEC filings are also available to the SEC at 1-800-SEC-0330. In addition, we are required to file electronic versions of these documents withpublic from the Commission throughSEC's World Wide Web site on the Commission's Electronic Data Gathering, Analysis, and Retrieval (EDGAR) system. The Commission maintains an internet siteInternet at http:/ /www.sec.gov that/www.sec.gov. This site contains reports, proxy and information statements and other information regarding registrantsissuers that file electronically with the Commission.SEC.

        We maintain a site on the World Wide Web at www.transgenomic.com. The information contained in our website is not part of this Prospectus and you should not rely on it in deciding whether to invest in our common stock.

        We have filed a registration statement,Registration Statement on Form S-3, of which this prospectusProspectus is a part, covering the securities offered hereby. As allowed by CommissionSEC rules, this prospectusProspectus does not contain all the information set forth in the registration statementRegistration Statement and the exhibits, financial statements and schedules thereto. We refer you to the registration statement,Registration Statement, the exhibits, financial statements and schedules thereto for further information. This prospectusProspectus is qualified in its entirety by such other information.


INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

        The CommissionSEC allows us to "incorporate by reference" information into this prospectus,Prospectus, which means that we can disclose important information to you by referring you to another document filed separately by us with the CommissionSEC under the Securities Exchange Act of 1934 (the "Exchange Act"). The information incorporated by reference is deemed to be part of this prospectus,Prospectus, except for any information superseded by information in this prospectus.Prospectus. We have filed our annual report on Form 10-K for the year ended December 31, 2000,2002, our quarterly reports on Form 10-Q for the quarters ended March 31, 2001,2003, and June 30, 2001, our2003, current report on Form 8-K dated May 29, 200130, 2003 and our proxy statement dated May 23, 2001April 18, 2003 with the CommissionSEC (File No. 000-30975), and these documents are incorporated herein by reference.

        Any documents we file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this prospectusProspectus and prior to the termination of the offering of the securities to which this prospectusProspectus relates will automatically be deemed to be incorporated by reference ininto this prospectusProspectus and to be part hereof from the date of filing those documents. Any statement contained in this prospectusProspectus or in a document incorporated by reference shall be deemed to be modified or superseded for all purposes to the extent that a statement contained in this prospectusProspectus or in any other document which is also incorporated by reference modifies or supersedes that statement.

        You may obtain copies of all documents which are incorporated in this prospectusProspectus by reference (other than the exhibits to those documents which are not specifically incorporated by reference herein) without charge by writing or calling Mr. Mitchell L. Murphy, at Transgenomic, Inc., 12325 Emmet Street, Omaha, NE, 68164, telephone number (402) 452-5400.

1811





4,500,000 Shares

TRANSGENOMIC, INC.

COMMON STOCK


PROSPECTUS


                        , 2003





PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.Other Expenses of Issuance and Distribution



Securities and Exchange Commission filing fees


$8,772


Legal fees and expenses15,000
Accounting fees and expenses10,000
Printing and engraving10,000
Miscellaneous expenses1,000

Total$44,772

Item 15.


Indemnification of Directors and Officers.




Item 14.    Other Expenses of Issuance and Distribution.

        The following table shows the estimated expenses in connection with the issuance and distribution of the common stock being registered:

Securities and Exchange Commission filing fees $400
Legal fees and expenses  20,000
Accounting fees and expenses  10,000
Printing and engraving  5,000
Miscellaneous expenses  1,000
  
Total $36,400


Item 15.    Indemnification of Directors and Officers.

        Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation to grant, indemnity to directors and officers in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement of expenses incurred) arising under the Securities Act of 1933.

        As permitted by the Delaware General Corporation Law, the Registrant's First Restated Certificate of Incorporation eliminates the personal liability of its directors for monetary damages for breach of fiduciary duty as a director, except for liability (1) for any breach of the director's duty of loyalty to the Registrant or its stockholders, (2) for acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law, (3) under Section 174 of the Delaware General Corporation Law (regarding unlawful dividends and stock purchases) or (4) for any transaction from which the director derived an improper personal benefit. If the Delaware General Corporation Law is amended to authorize further elimination or limiting of directors' personal liability, then the First Amended and Restated Certificate provides that the personal liability of directors will be eliminated or limited to the fullest extent provided under the Delaware General Corporation Law.

        As permitted by the Delaware General Corporation Law, the Registrant's First Amended and Restated Certificate of Incorporation and its Bylaws provide that (1) the Registrant is required to indemnify its directors and officers to the fullest extent permitted by the Delaware General Corporation Law, subject to certain very limited exceptions, (2) the Registrant may indemnify its other employees and agents as set forth in the Delaware General Corporation Law, (3) the Registrant is required to advance expenses, as incurred, to its directors and executive officers in connection with a legal proceeding to the fullest extent permitted by the Delaware General Corporation Law, subject to certain conditions and (4) the rights conferred by the First Amended and Restated Certificate of Incorporation and Bylaws are not exclusive.

        The Delaware General Corporation Law authorizes a corporation to indemnify its directors and officers provided that the corporation shall not eliminate or limit the liability of a director as follows:

    (a)
    for any action brought by or in the right of a corporation where the director or officer is adjudged to be liable to the corporation, except where a court determines the director or officer is entitled to indemnity;

    (b)
    for acts or omissions not in good faith or which involve conduct that the director or officer believes is not in the best interests of the corporation;

    (c)
    for knowing violations of the law;

II-1


      (d)
      for any transaction from which the directors derived an improper personal benefit; and

      (e)
      for payment of dividends or approval of stock repurchases or redemptions leading to liability under Section 174 of the Delaware General Corporation Law.

              The Delaware General Corporation Law requires a corporation to indemnify a director or officer to the extent that the director or officer has been successful, on the merits or otherwise, in defense of any action, suit or proceeding for which indemnification is lawful.

              The CompanyRegistrant maintains a director and officer insurance policy which insures the directors and officers of the CompanyRegistrant against damages, judgments, settlements and costs incurred by reason of certain wrongful acts committed by such persons in their capacities as directors and officers.


      Item 16.    Exhibits.

      2.1Asset Purchase Agreement, dated May 16, 2000 between the Registrant and SD Acquisition Inc. (incorporated by reference to Exhibit 2 to Amendment No. 1 to Registration Statement on Form S-1 (Registration No. 333-32174) as filed on May 17, 2000)
      2.2Agreement and Plan of Merger, dated as of April 30, 2001 among Transgenomic, Inc., TBIO Nebraska, Inc., TBIO, Inc. and Annovis, Inc. (incorporated by reference to Exhibit 2.1 to Report on Form 8-K (Registration No. 000-30975) as filed on May 31, 2001)
      2.3Addendum to Agreement and Plan of Merger, dated as of May 18, 2001 among Transgenomic, Inc., TBIO Nebraska, Inc., TBIO, Inc. and Annovis, Inc. (incorporated by reference to Exhibit 2.2 to Report on Form 8-K (Registration No. 000-30975) as filed on May 31, 2001)
      4Form of Certificate of the Registrant's Common Stock (incorporated by reference to Exhibit 4 to Registration Statement on Form S-1 (Registration No. 333-32174) as filed on March 10, 2000)
      5Opinion of Kutak Rock LLP
      23(a)Consent of Deloitte & Touche LLP
      23(b)Consent of Kutak Rock LLP (included as part of opinion filed as Exhibit 5).
      24Powers of Attorney (included on page II-5 of this Registration Statement).
        4
        Form of Certificate of the Registrant's Common Stock (1)

        5
        Opinion of Kutak Rock LLP

        23.1
        Consent of Deloitte & Touche LLP

        23.2
        Consent of Kutak Rock LLP (included in Exhibit 5)

        24
        Powers of Attorney (included on page II-4 of this Registration Statement)

      (1)
      This Exhibit is incorporated by reference to the Registration Statement of the Registrant (Registration No. 333-32174), which was filed on March 10, 2000.


      Item 17.    Undertakings.

        (a)

        We undertake:

        (1)

        To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

          (i)

        to include any prospectus required by section 10(a)(3) of the Securities Act of 1933;

        (ii)

        to reflect in the prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement;

        (iii)
        to include any material information with respect to the plan of distribution not previously disclosed in this registration statement or any material change to such information in this registration statement (notwithstandingstatement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of a prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" in this registration statement); statement;

                (iii)  to include any material information with respect to the plan of distribution not previously disclosed in this registration statement or any material change to such information in this registration statement

      provided, however, that the undertakings set forth in paragraphs (i) and (ii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to section 13 or section 15(d) of the

      II–2


            Securities Exchange Act of 1934 that are incorporated by reference in this registration statement.

        (2)

        That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities

        II-2



        offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

        (3)

        To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

        (b)

                (4)   That, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in this registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

        (h)

                (5)   Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, referred to in Item 15 (other than the insurance policies referred to therein), or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted against the Registrant by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.

      II–3II-3




        SIGNATURES

                Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Omaha, State of Nebraska, on the 24th28th day of September, 2001.August, 2003.

         TRANSGENOMIC, INC.

         


        BY:By:

         

        /S/ s/  
        COLLIN J. D'SILVA
        Collin J. D'Silva,
        President and Chief Executive Officer

        POWER OF ATTORNEY

                Each person whose signature appears below hereby authorizes Collin J. D'Silva, and Gregory J. Duman, and each of them individually, as attorney-in-fact, to sign on his or her behalf, individually and in each capacity stated below, any amendment, including post-effective amendments to this registration statement, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission.

                Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities indicatedand on the 24th day of September, 2001.dates indicated.

        Signature
        Title

        Date: August 28, 2003

        By:

         
        /s/  COLLIN J. D'SILVA      
        Collin J. D'Silva,
        Chairman of the Board, Director,
        President, and Chief Executive Officer and
        Director (Principal Executive Officer)

        Date: August 28, 2003

        By:


        /s/  
        MICHAEL J. DRAPER      
        Michael J. Draper,
        Chief Financial Officer
        (Principal Financial Officer)

        Date: August 28, 2003

        By:


        /s/  
        GREGORY J. DUMAN      
        Gregory J. Duman,
        Director

        Date: August 28, 2003

        By:

         

        Chief Financial Officer, Director (Principal Financial Officer)

        /s/ 
        STEPHEN F. DWYER   
        Stephen F. Dwyer


        Director

        /s/  
        JEFFREY SKLAR      
        Jeffrey Sklar, M.D., Ph.D.
        Director

        Date: August 28, 2003

        By:

         

        Director

        /s/  
        ROLAND J. SANTONI      
        Roland J. Santoni,
        Director

        Date: August 28, 2003

        By:

         

        Director

        /s/  PARAG SAXENA      
        Parag Saxena,


        Director

        II–4II-4



        EXHIBIT INDEX

        Exhibit No.

         Description



        2.14 Asset Purchase Agreement, dated May 16, 2000 between the Registrant and SD Acquisition Inc. (incorporated by reference to Exhibit 2 to Amendment No. 1 to Registration Statement on Form S-1 (Registration No. 333-32174) as filed on May 17, 2000)

        2.2


        Agreement and Plan of Merger, dated as of April 30, 2001 among Transgenomic, Inc., TBIO Nebraska, Inc., TBIO, Inc. and Annovis, Inc. (incorporated by reference to Exhibit 2.1 to Report on Form 8-K (Registration No. 000-30975) as filed on May 31, 2001)

        2.3


        Addendum to Agreement and Plan of Merger, dated as of May 18, 2001 among Transgenomic, Inc., TBIO Nebraska, Inc., TBIO, Inc. and Annovis, Inc. (incorporated by reference to Exhibit 2.2 to Report on Form 8-K (Registration No. 000-30975) as filed on May 31, 2001)

         4


        Form of Certificate of the Registrant's Common Stock (incorporated by reference to Exhibit 4 to Registration Statement on Form S-1 (Registration No. 333-32174) as filed on March 10, 2000)(1)

        5

         

        Opinion of Kutak Rock LLP as to the legality of the securities.

        23(a)23.1

         

        Consent of Deloitte & Touche LLP

        23(b)23.2

         

        Consent of Kutak Rock LLP (contained(included in opinion of counsel filed as Exhibit 5).

        24

         

        Powers of Attorney (included on page II-5II-4 of this Registration Statement).

        II–5


        (1)
        This Exhibit is incorporated by reference to the Registration Statement of the Registrant (Registration No. 333-32174), which was filed on March 10, 2000.



        QuickLinks

        TABLE OF CONTENTS
        ABOUT THIS PROSPECTUS SUMMARY
        Shares to be Sold by Selling StockholdersTRANSGENOMIC, INC.
        RISK FACTORS
        FORWARD-LOOKING STATEMENTSUSE OF PROCEEDS
        SELLING STOCKHOLDERS
        PLAN OF DISTRIBUTION
        LEGAL MATTERSEXPERTS
        EXPERTSLEGAL OPINIONS
        WHERE YOU CAN FIND MORE INFORMATION
        INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
        PART II INFORMATION NOT REQUIRED IN PROSPECTUS
        SIGNATURES
        EXHIBIT INDEX