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As Filed With Thefiled with the Securities Andand Exchange Commission On July 20, 2000 on May 30, 2017

Registration Statement No. 333-______ 333 - 218062

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION WASHINGTON,
Washington, D.C. 20549 --------------------------- FORM


Amendment No. 1

to

Form S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933 --------------------------- TITAN MOTORCYCLE CO. OF AMERICA (Exact


Diffusion Pharmaceuticals Inc.

(Exact name of registrant as specified in its Charter) NEVADA 86-0776876 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 2222 WEST PEORIA AVENUE PHOENIX, ARIZONA 85029 (602) 861-6977 (Address, including zip code, and telephone number, including area code, of principal executive offices) ------------------------------- FRANCIS S. KEERY, CHIEF EXECUTIVE OFFICER TITAN MOTORCYCLE CO. OF AMERICA 2222 WEST PEORIA AVENUE PHOENIX, ARIZONA 85029 (602) 861-6977 (Name,charter)


Delaware

2020 Avon Court, #4

Charlottesville, VA 22902

(434) 220-0718

30-0645032

(State of Incorporation)

(Address, including zip code, and telephone number, including area code, of

registrant’s principal executive offices)

(I.R.S. Employer
Identification No.)


David G. Kalergis
Chief Executive Officer
2020 Avon Court, #4
Charlottesville, VA 22902
(434) 220-0718

(Name, address, including zip code, and telephone number, including area code, of agent for service) ------------------------------- COPY TO: STEVEN D. PIDGEON, ESQ. SNELL & WILMER L.L.P. ONE ARIZONA CENTER PHOENIX, ARIZONA 85004-0001 (602) 382-6000 -------------------------------- APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:


With a Copy to:

David S. Rosenthal, Esq.
Dechert LLP
1095 Avenue of the Americas
New York, New York 10036
(212) 698-3500


Approximate date of commencement of proposed sale to the public:From time to time after the effective date of this registration statement becomes effective. Registration Statement.


If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. |_| 2

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. |X|

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. |_|

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. |_|

If delivery ofthis Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the prospectus is expected to be madeCommission pursuant to Rule 434, please462(e) under the Securities Act, check the following box. |_|

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large Accelerated Filer ☐

Accelerated Filer ☐

Non-Accelerated Filer ☐

Smaller Reporting Company☒

Emerging Growth Company ☐

(Do not check if a smaller reporting company)

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities to be Registered

 

Amount to be
Registered
(1)(3)

  

Proposed Maximum
Offering Price per

Security(2)

  

Proposed Maximum
Aggregate Offering

Price(2)

  

Amount of
Registration Fee

 

Common Stock, $0.001 par value per share

  26,467,801  $2.90  $76,756,622.90  $8,896.10(4)


Proposed Maximum Proposed Maximum Title of Each Class of Amount to be Offering Price Aggregate Amount of Securities to be Registered Registered Per Share Offering Price Registration Fee Common Stock, $.001 par value 4,752,632 Shares(1) $ .84(2) $ 3,992,210.80 $ 1,053.94 Total 4,752,632 Shares(1) $ 3,992,210.80 $ 1,053.94
(1) Shares of common stock that may be offered pursuant to this registration statement consist of 3,010,526 shares issuable upon conversion of 1,300 shares of Series C Convertible Preferred Stock and 1,742,106 shares issuable upon exercise of certain warrants. For purposes of estimating the number of shares of common stock to be included in this registration statement, we calculated (i) 200% of the aggregate number of shares of common stock issuable in connection with the conversion of the Series C Convertible Preferred Stock, determined as if the Series C Convertible Preferred Stock, together with 24 months of accrued and unpaid dividends thereon (Series C Convertible Preferred Stock holders are entitled to dividends in the form of common stock, if declared by the Board, at a rate of 5% per year), were converted in full at the conversion price of $0.95, which was the conversion price in effect on the date this Registration Statement is first filed, plus (ii) 100% of the number of shares of common stock issuable upon exercise of the warrants.

(1)

Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), the shares being registered hereunder include such indeterminate number of shares of the Common Stock of the Company as may be issuable with respect to the shares being registered hereunder as may be issuable as a result of any stock dividend, stock split, recapitalization or other similar transaction.

(2)

Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) under the Securities Act. The offering price per share and aggregate offering price are based upon the average of the high and low prices per share of the Company’s common stock, $0.001 par value per share, as reported on the NASDAQ Capital Market, on May11, 2017, a date within five business days prior to the filing of this registration statement.

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(3)

Includes (i) 12,376,329 shares issued or issuable upon conversion of the Company’s Series A Convertible Preferred Stock, (ii) 13,555,887 shares issued or issuable upon exercise of the Company’s warrants issued in connection with its private placement of Series A Convertible Preferred Stock and (iii) an estimated 535,585 shares issuable as payment of dividends accruing through October 1, 2017 with respect to the Company’s Series A Convertible Preferred Stock.

(4)Previously paid.

The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 as amended, thisor until the Registration Statement also coversshall become effective on such indeterminate additional shares of common stockdate as may become issuable as a result of stock splits, stock dividends or other similar transactions. (2) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c), based upon the average of the high and low prices of the common stock on July 19, 2000, as reported by the Nasdaq SmallCap Market. ---------------------------------- THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a), MAY DETERMINE. 3 THE INFORMATION IN THIS PROSPECTUS IS NOT COMPLETE AND MAY BE CHANGED. THESE SECURITIES MAY NOT BE SOLD UNTIL THE REGISTRATION STATEMENT FILED WITH THE SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS PROSPECTUS IS NOT AN OFFER TO SELL THESE SECURITIES AND IT IS NOT SOLICITING AN OFFER TO BUY THESE SECURITIES IN ANY STATE WHERE THE OFFER OR SALE IS NOT PERMITTED. PROSPECTUS Titan Motorcycle Co. of America 4,752,632 Common Shares This prospectus relates to shares of our common stock that may be sold by the selling stockholders named under the section of this prospectus entitled "Selling Stockholders." The selling stockholders may sell some or all of the common stock through ordinary brokerage transactions, directly to market makers of our shares, or through any of the other means described in the section entitled "Plan of Distribution" beginning on page 14. The selling stockholders will receive all of the proceeds from the sale of the common stock, less any brokerage or other expenses of sale incurred by them. We are paying for the costs of registering the shares covered by this prospectus. Our common stock is traded on the Nasdaq SmallCap Market under the symbol "TMOT." The closing sales price of our common stock as reported by the Nasdaq SmallCap Market on July 19, 2000 was $.88 per share. ----------------------------- BEFORE PURCHASING ANY OF THE SHARES COVERED BY THIS PROSPECTUS, CAREFULLY READ AND CONSIDER THE RISK FACTORS INCLUDED IN THE SECTION ENTITLED "RISK FACTORS" BEGINNING ON PAGE 1. YOU SHOULD BE PREPARED TO ACCEPT ANY AND ALL OF THE RISKS ASSOCIATED WITH PURCHASING THE SHARES, INCLUDING A LOSS OF ALL OF YOUR INVESTMENT. NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED THE SALE OF THE COMMON STOCK OR DETERMINED THAT THE INFORMATION IN THIS PROSPECTUS IS ACCURATE OR COMPLETE. IT IS ILLEGAL FOR ANY PERSON TO TELL YOU OTHERWISE. ------------------------- The date of this prospectus is July ____, 2000. 4 TABLE OF CONTENTS Page TITAN MOTORCYCLE CO. OF AMERICA................................................1 RISK FACTORS...................................................................1 FORWARD LOOKING STATEMENTS.....................................................7 USE OF PROCEEDS................................................................8 SELLING STOCKHOLDERS...........................................................8 DESCRIPTION OF SECURITIES......................................................9 PLAN OF DISTRIBUTION..........................................................14 LEGAL OPINIONS................................................................15 EXPERTS.......................................................................15 WHERE YOU CAN FIND MORE INFORMATION...........................................15 YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED OR INCORPORATED BY REFERENCE IN THIS PROSPECTUS AND IN ANY ACCOMPANYING PROSPECTUS SUPPLEMENT. NO ONE HAS BEEN AUTHORIZED TO PROVIDE YOU WITH DIFFERENT INFORMATION. THE COMMON STOCK IS NOT BEING OFFERED IN ANY JURISDICTION WHERE THE OFFER IS NOT PERMITTED. YOU SHOULD NOT ASSUME THAT THE INFORMATION IN THIS PROSPECTUS OR ANY PROSPECTUS SUPPLEMENT IS ACCURATE AS OF ANY DATE OTHER THAN THE DATE ON THE FRONT OF THOSE DOCUMENTS. 5 TITAN MOTORCYCLE CO. OF AMERICA We design and manufacture high-end customized heavyweight motorcycles. We build both highly customized, individually assembled motorcycles and high-end, assembly-line produced motorcycles. A heavyweight motorcycle is a motorcycle with an engine size or displacement of 651 cubic centimeters or greater. Our products are distributed through a network of 61 domestic dealers and 20 foreign dealers. We currently maintain three product lines. PREMIUM MOTORCYCLES: We manufacture seven premium models with a package of over 200 custom options. Customers design their motorcycles by choosing colors, paint design, finish, fenders and various performance and aesthetic enhancements. Premium models are typically constructed and delivered in six to ten weeks from the order date. Our premium models represented approximately 75% of our fiscal year 1999 revenues. The average retail selling price for our premium models is approximately $35,000. "PHOENIX BY TITAN" MOTORCYCLES: Our "Phoenix by Titan" line of motorcycles was introduced in March 1999. We manufacture four "Phoenix by Titan" models with six standard customization packages available through our dealerships. Our Phoenix models represented approximately 23% of our fiscal year 1999 revenues. The average retail selling price for the "Phoenix by Titan" models is approximately $25,000. APPAREL AND ACCESSORIES: We have recently developed a line of Titan apparel and accessories. We are also developing a premium line of upgrade parts which are compatible with Titan and other "V Twin" motorcycles. We are a Nevada corporation formed on January 10, 1995. Our principal executive offices are located at 2222 West Peoria Avenue, Phoenix, Arizona and our telephone number is (602) 861-6977. RISK FACTORS BEFORE PURCHASING ANY OF THE SHARES COVERED BY THIS PROSPECTUS, YOU SHOULD CAREFULLY READ AND CONSIDER THE RISK FACTORS SET FORTH BELOW. YOU SHOULD BE PREPARED TO ACCEPT ANY AND ALL OF THE RISKS ASSOCIATED WITH PURCHASING THE SHARES, INCLUDING A LOSS OF ALL OF YOUR INVESTMENT. WE WILL BE UNABLE TO CONTINUE OUR OPERATIONS IF WE ARE UNABLE TO REPLACE OUR SENIOR CREDIT FACILITY AND RAISE NEW CAPITAL The report of the independent accountants on the financial statements included in our Form 10KSB for the fiscal year ended January 1, 2000 included an explanatory paragraph discussing going concern issues. These issues included the fact that the Company's primary financing source expired April 10, 2000, at year-end we did not have another facility available to refinance this debt, and we were incurring losses from operations. We have received modifications and extensions through September 11, 2000 to the Wells Fargo line of credit. The latest extension was granted in light of our continuing inability to date to secure a new credit facility to replace the existing line of credit. In this regard, discussions with two potential new lenders that had expressed a preliminary interest in replacing and expanding the existing facility have terminated, and we are in the process of seeking additional capital and a new lender. Among other things, the modification and extension with Wells Fargo further limits our borrowing capacity and requires that we develop and implement profit improvement and asset reduction plans and engage an investment banker to seek strategic alternatives, including selling the business. If we are unable to replace the Wells Fargo line with a new credit facility, we will be forced to sell or wind down our business. In addition, the loan agreement with Wells Fargo contains various continuing obligations, including financial covenants. If the Company fails to satisfy these covenants, it would be in default under the loan agreement, which could force us to liquidate or file for reorganization. 1 6 WE ARE SUFFERING FROM A LIQUIDITY CRISIS Our operations require significant levels of cash to fund the production of our motorcycles. We have funded our operations with our existing credit facility, equity infusions and cash from operations. Our lender has reduced our credit line and we may not be able to raise new capital. In addition, we are receiving increasing pressure for additional payments from trade creditors, and are encountering difficulties in obtaining necessary parts from these suppliers to manufacture our motorcycles. Many of our dealers receive floor plan financing for our products through TransAmerica Commercial Finance Corporation and Deutsche Financial Services. The dealers are the obligors under these floor plan agreements and are responsible for all principal and interest payments. However, we are subject to a standard repurchase agreement that requires us to buy back any of our motorcycles at the wholesale price if the dealer defaults and the motorcycles are repossessed by one of these floor plan providers. Deutsch Financial Service and TransAmerica Commercial Finance Corporation have notified us that they intend to terminate (in Transamerica's case) or may terminate (in Deutsch's case) these arrangements unless dealer payment guarantees or other accommodations are made. In addition, various distributorships owned by the Keery family, which controls Titan Motorcycles, are in the process of being sold or shut down. These dealerships have historically accounted for a substantial portion of our sales. There is currently $600,000 in net receivables due to us from these affiliated distributorships, collection of which is uncertain. As a result, the inventory held by these dealerships will be returned to us through Transamerica, with a corresponding payment due Transamerica in the amount of $1,300,000. The Company does not have the cash to make this payment, and has reached a verbal agreement with Transamerica that would allow it to resell the returned inventory to dealers and repay Transamerica over a three month period. In light of the foregoing, we are actively reviewing a number of possible strategic alternatives, including: X seeking alternative sources of capital or debt financing; X negotiating to maintain the Transamerica and Deutsch facilities in place; X implementing a further substantial reduction in our operations and workforce (we reduced our workforce by approximately 25% on July 20, 2000); and X selling or merging the Company. There can be no assurance that we will be able to implement any of these strategies. The failure to accomplish one or more of these strategies would materially adversely effect our financial performance and liquidity. We might also be forced to liquidate or file for reorganization under the federal bankruptcy laws. WE FACE POSSIBLE DELISITING FROM THE NASDAQ SMALLCAP MARKET Our common stock is currently listed on the Nasdaq SmallCap Market. Our net tangible assets, however, fell below the minimum required by Nasdaq, primarily as a result of our Series A and Series B Convertible Preferred Stock being classified as mezzanine debt rather than equity. Nasdaq notified us of its intention to delist our common stock from the Nasdaq SmallCap Market unless we can supply them with a specific plan as to how we expect to achieve and sustain compliance with all Nasdaq SmallCap Market listing requirements. Subsequent to Nasdaq's notification, the Company's Series A and Series B preferred stockholders agreed to modify the terms of their preferred stock so that it would be characterized under generally accepted accounting principles as capital, rather than as mezzanine instruments. Nasdaq also has inquired about the explanatory paragraph in the report rendered by the Company's independent public accountant regarding the Company's going concern issues, as more fully described above. In light of the Company's current 2 7 situation, it is unsure whether the Nasdaq will take action to delist the Company's securities and, if so, what the timing of such an action would be. If we fail to maintain Nasdaq listing, the market value of the common stock may decline and trading in our stock is likely to be materially adversely effected. Among other things, because our common stock would then constitute "penny stock" under the Securities Exchange Act of 1934, as amended, any broker engaging in a transaction in our securities would be required to provide any customer with a risk disclosure document, disclosure of market quotations, if any, disclosure of the compensation of the broker-dealer and its salesperson in the transaction, and monthly account statements showing the market values of our securities held in the customer's accounts. The bid and offer quotation and compensation information must be provided prior to effecting the transaction and must be contained on the customer's confirmation. If brokers become subject to the "penny stock" rules when engaging in transactions in our securities, they would become less willing to engage in such transactions, thereby making it more difficult for our securityholders to sell their common stock, which may result in a decline in stock value. WE HAVE A HISTORY OF LOSSES AND WE MAY LOSE MONEY IN THE FUTURE We incurred losses of $8.1 million in fiscal year 1999 and a loss of $1,487,215 in the first quarter of 2000. In light of our cash crisis, inability to finance full production, and reduction in workforce, we may incur losses in the future. To achieve and maintain profitability, we need to generate an increased level of market acceptance for our products. Our success depends on our ability to meet the following objectives, none of which we may achieve: X increase consumer awareness of our products; X establish and maintain a reputation for high quality products; X increase sales through our independent third party dealers; X expand our dealer network; and X finance these activities. We cannot assure you that we will meet these objectives. WE DEPEND HEAVILY ON THIRD PARTY PARTS SUPPLIERS AND ARE EXPERIENCING DIFFICULTIES WITH THEM We operate primarily as an assembler and rely heavily on a number of major component manufacturers to supply us with almost all of our parts. Any significant adverse variation in quantity, quality or cost would adversely affect our volume and cost of production until we could identify alternative sources of supply. In addition, we are receiving increasing pressure for additional payments from trade creditors, and are encountering difficulties in obtaining necessary parts from these suppliers to manufacture our motorcycles. WE DEPEND HEAVILY ON INDEPENDENT THIRD PARTY DEALERS AND OUR RESULTS OF OPERATIONS COULD BE NEGATIVELY IMPACTED IF THE DEALERS FAIL TO ADEQUATELY PROMOTE OUR PRODUCTS, IMAGE AND NAME Failures by independent third party dealers to adequately promote our products could negatively affect our results of operations. Our products are sold primarily through independent dealers. As a result, we are unable to fully control the presentation, delivery and service of our products to the final customer. We depend heavily on our dealers' willingness and ability to promote our products, image and name. As a result of our financial situation, we are losing dealerships operated by principals of the Company, and may lose others. This would materially adversely affect our ability to continue in business. 3 8 COMPLICATIONS IN ESTABLISHING AND INTEGRATING OUR NEW "PHOENIX BY TITAN" LINE OF MOTORCYCLES COULD MATERIALLY ADVERSELY AFFECT OUR EXPENSES, GROSS MARGINS AND OPERATING RESULTS We introduced our "Phoenix by Titan" line of heavyweight motorcycles in 1999. Unlike our custom motorcycles, we manufacture these motorcycles in four models through an assembly line process. Six standard customization packages are available through the dealerships for each of the four models. While initial orders have been substantial, there can be no assurance that we will be able to accomplish the following goals: X effectively manage any ongoing difficulties that we may experience; X successfully adapt to an assembly line manufacturing process; X gain or maintain consumer acceptance of this product line; and X finance the production of the motorcycles. Also, we cannot assure you that this line, which is less expensive, will not take sales away from our higher end custom motorcycles or that we will not face other difficulties with this line. Any of these issues could materially adversely affect our expenses, gross margins and operating results. BECAUSE WE SELL A DISCRETIONARY PRODUCT, A DOWNTURN IN THE ECONOMY COULD NEGATIVELY AFFECT OUR GROWTH AND PROFITABILITY Motorcycles in the high-end customized heavyweight market are discretionary purchase items. A recession or economic downturn may reduce consumer spending on these types of items and negatively affect our growth and profitability. An economic downturn could result from a number of factors outside of our control, including: X employment levels; X business conditions; X interest rates; X inflation levels; and X taxation rates. COMPETITION IN OUR MARKET HAS INCREASED SUBSTANTIALLY AND MAY RESULT IN PRICE REDUCTIONS, REDUCED GROSS MARGINS AND A LOSS OF OUR MARKET SHARE While we operate in the high-end segment of the heavyweight cruiser market, the overall heavyweight cruiser market has recently experienced a substantial increase in production capacity and new entrants. Some of our competitors have technical, production, personnel and financial resources that exceed ours and we cannot assure you that the competition will not materially adversely affect our business, financial condition or results of operations. The increased competition could result in price reductions, reduced gross margins and a loss in our market share. Major competitors in the heavyweight cruiser market are: X Harley-Davidson(TM), the heavyweight cruiser market leader, which is reportedly increasing its capacity to over 160,000 units from approximately 148,000 units; X BMW, which entered the segment in 1997 with their "R1200C" model; X Excelsior-Henderson, which entered the market with their "Super X" model; and X Polaris, which recently entered the market with their "Victory V92C" model. 4 9 OUR PRODUCTS COULD CONTAIN DEFECTS CREATING PRODUCT RECALLS AND WARRANTY CLAIMS THAT COULD MATERIALLY ADVERSELY AFFECT OUR FUTURE SALES AND PROFITABILITY Our products could contain unforeseen defects. These defects could create product recalls or warranty claims that could increase our costs and affect profitability. Significant and continuous defects also could negatively impact the goodwill and quality associated with our brand name. Defects also could give rise to litigation resulting in liability for judgments that could have a significant impact on our business, operations and financial condition. Product recalls resulting from unforeseen defects could subject us to a significant financial commitment and have a significant impact on our business, operations and financial condition. WE DEPEND ON FOREIGN VENDORS FOR CERTAIN COMPONENT PARTS, WHICH EXPOSES US TO RISKS THAT COULD MATERIALLY AND ADVERSELY AFFECT OUR OPERATING RESULTS We depend on foreign vendors for certain component parts, which exposes us to additional risks. Our reliance on foreign vendors exposes us to risks such as: X currency fluctuations that may adversely affect the value of goods purchased; X trade restrictions; X delays in shipping; X changes in tariffs; and X difficulties in enforcing supply arrangements. The occurrence of any of these risks could materially and adversely affect our operating results. WE MAY ATTEMPT TO ESTABLISH SALES OPERATIONS IN FOREIGN MARKETS, WHICH REQUIRES SIGNIFICANT MANAGEMENT ATTENTION AND FINANCIAL RESOURCES, AND THIS STRATEGY MAY NOT BE SUCCESSFUL If we can obtain necessary financing to sustain our operations, we may attempt to establish sales operations in foreign markets; however, we cannot assure you that we will be able to successfully manage the inherent risks and complications associated with operating in foreign markets. These risks and complications of operating in foreign markets include the following: X selecting and monitoring dealers; X establishing effective dealer training; X transporting inventory; X achieving market acceptance of our products; X parts availability; X changes in diplomatic and trade relationships; X tariffs; X currency exchange rate; and X unexpected changes in regulatory requirements. WE ARE SUBJECT TO VARIOUS ENVIRONMENTAL REGULATIONS AND OUR FAILURE TO COMPLY COULD NEGATIVELY IMPACT OUR OPERATIONS We are subject to various federal, state and local environmental regulations. Our failure to comply with these regulations could result in any one or more of the following: X restrictions on our ability to expand or modify our current operations or facilities; X significant expenditures in achieving compliance with the regulations; X significant liabilities exceeding our available resources; and X cessation of our operations. 5 10 Our business and assets could be materially adversely affected if environmental regulations require that we modify our facilities or otherwise limit our ability to conduct our operations. Any significant expenses incurred as a result of environmental liabilities could have a material adverse affect on our business, operating results and financial condition. OUR BUSINESS WILL SUFFER IF WE ARE UNABLE TO KEEP OUR SENIOR EXECUTIVE OFFICERS AND KEY EMPLOYEES We rely considerably on the abilities of Francis S. Keery, our Chairman and Chief Executive Officer, and Patrick Keery, our President. We also depend to a significant extent upon the performance of our executive management team. The unavailability or loss of services of any of these individuals, or the failure to attract and retain qualified personnel to replace them, could have a material adverse affect on our business. We only have a non-competition agreement with our Chief Financial Officer and we cannot assure you that his agreement will be enforceable or effective in retaining him. Also, we cannot assure you that our other executive officers will not leave us. OUR FAILURE TO COMPLY WITH VARIOUS REGULATORY APPROVALS AND GOVERNMENTAL REGULATIONS COULD NEGATIVELY IMPACT OUR OPERATIONS Our motorcycles must comply with certain governmental approvals and certifications regarding noise, emissions and safety characteristics. Our failure to comply with these requirements could prevent us or delay us from selling our products, which would have a significant negative impact on our operations. OUR QUARTERLY RESULTS MAY FLUCTUATE SIGNIFICANTLY, WHICH MAY CAUSE VOLATILITY IN OUR STOCK PRICE Our quarterly operating results may fluctuate significantly as a result of a variety of factors, many of which are outside of our control. These factors include: X manufacturing delays; X the amount and timing of orders from dealers; X disruptions in the supply of key components and parts; X seasonal variations in the sale of our products; and X general economic conditions. X liquidity issues WE COULD BE REQUIRED TO REDEEM OUR SERIES A, SERIES B AND SERIES C CONVERTIBLE PREFERRED STOCK AT A PREMIUM, WHICH WOULD REQUIRE A LARGE EXPENDITURE OF CAPITAL AND COULD HAVE A MATERIAL ADVERSE AFFECT ON OUR FINANCIAL CONDITION The holders of our Series A, Series B and Series C Convertible Preferred Stock have the right to require us to redeem their Preferred Stock upon the occurrence of certain events. The redemption of our Series A, Series B or Series C Convertible Preferred Stock would require a large expenditure of capital and we may not have sufficient funds to satisfy the redemption. However, the holders of the Series A and Series B Convertible Preferred Stock have agreed to amend the terms and conditions of the Series A and Series B Convertible Preferred Stock through the filing of an amended and restated certificate of designations. The amendments will allow us to deliver a control notice to the Series A or Series B holders against their delivery of a redemption notice if the event or circumstances giving rise to the redemption notice were outside of our control. The delivery of a control notice will permit us to adjust the conversion price of the Series A or Series B Convertible Preferred Stock in lieu of redemption. Ultimately, this will allow us to classify the Series A and Series B Convertible Preferred Stock as equity rather than mezzanine instruments in accordance with generally accepted accounting principles. 6 11 WE MAY ISSUE ADDITIONAL STOCK AND DILUTE YOUR OWNERSHIP PERCENTAGE Certain events over which you have no control could result in the issuance of additional shares of our common stock, which would dilute your ownership percentage. We may issue additional shares of common stock or preferred stock: X to raise additional capital or finance acquisitions; X upon the exercise or conversion of outstanding options, warrants and shares of convertible preferred stock; or X in lieu of cash payment of dividends. There are currently outstanding convertible preferred stock, warrants, and options to acquire up to 7,365,720 additional shares of common stock. If converted or exercised, these securities will dilute your percentage ownership of common stock. These securities, unlike common stock, provide for antidilution protection upon the occurrence of stock dividends, combinations, capital reorganizations and other events. If one or more of these events occurs, the number of shares of common stock that may be acquired upon conversion or exercise would increase. In addition, you could face further dilution of your ownership percentage as a result of a decline in the market price of our common stock, which would result in an increase in the number of shares of common stock issuable upon conversion of the Series A, Series B or Series C Convertible Preferred Stock, or in the event of certain defaults under the Series A, Series B or Series C Preferred Stock, which could result in a dilution adjustment. Any such event could adversely affect the price of our stock and our ability to raise additional capital. OUR GOVERNING DOCUMENTS AND NEVADA LAW CONTAIN PROVISIONS THAT COULD PREVENT TRANSACTIONS IN WHICH YOU WOULD RECEIVE A PREMIUM FOR YOUR STOCK Our Articles of Incorporation and the Nevada Revised Statutes contain provisions that could have the effect of delaying, deferring, or preventing a change in control and the opportunity to sell your shares at a premium over current market prices. Although these provisions are intended to protect us and our stockholders from unwanted takeovers, their effect could hinder or prevent transactions in which you might otherwise receive a premium for your common stock over then-current market prices, and may limit your ability to approve transactions that may be in your best interests. As a result, the mere existence of these provisions could adversely affect the price of our common stock. FORWARD LOOKING STATEMENTS This prospectus contains or incorporates forward-looking statements including statements regarding, among other items, our business strategy, growth strategy, and anticipated trends in our business. We may make additional written or oral forward-looking statements from time to time in filings with the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

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The information in this prospectus is not complete and may be changed. The Selling Stockholders may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and is not soliciting an offer to buy or sell these securities in any jurisdiction where the offer or sale is not permitted.

SUBJECT TO COMPLETION, DATED MAY 30, 2017

Diffusion Pharmaceuticals Inc.



Common Stock
Up to 26,467,801 Shares of Common Stock
Offered by the Selling Stockholders

This prospectus relates to the resale or otherwise. When we use the words "believe," "expect," "anticipate," "project" and similar expressions, this should alert you that this is a forward-looking statement. Forward-looking statements speak only as of the date the statement is made. These forward-looking statements are based largely on our expectations. They are subject to a number of risks and uncertainties, some of which cannot be predicted or quantified and are beyond our control. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. Statements in this prospectus, and in documents incorporated into this prospectus, including those set forth in "Risk Factors," describe factors, among others, that could contribute to or cause these differences. In light of these risks and uncertainties, there can be no assurance that the forward-looking information contained in this prospectus will in fact transpire or prove to be accurate. All subsequent written and oral forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their entirety by this section. 7 12 USE OF PROCEEDS We will not receive any proceeds from the sale of any shares offered by this prospectus. SELLING STOCKHOLDERS The following table provides information about the selling stockholders. The shares offered by this prospectus will be offeredother disposition from time to time by the selling stockholders named below, or byidentified herein (including, except as the context may otherwise require, their donees, pledgees, donees, transferees or other successors in interestsuccessors-in-interest, the “Selling Stockholders”), of, subject to them. The adjustment, up to26,467,801shares shown as offered by Esquire Trade & Finance Inc. and Celeste Trust Reg. under this prospectus may be issued upon conversion of the Series C Convertible Preferred Stock and exercise of warrants acquired by these selling stockholders from us in a private placement completed on June 20, 2000. Under the terms of the Series C Convertible Preferred Stock and the related warrants, no selling stockholder may convert the Series C Convertible Preferred Stock or exercise warrants to the extent that conversion or exercise would cause the selling stockholder's beneficial ownership of our common stock, (excluding shares underlying unconverted Series C Convertible Preferred Stock and unexercised warrants) to exceed 9.99% of the outstanding shares of common stock.
SHARES OWNED AFTER OFFERING PERCENTAGE OF MAXIMUM NUMBER OF (ASSUMING ALL COMMON STOCK SHARES OWNED SHARES TO BE SOLD SHARES OFFERED OWNED AFTER NAME OF SELLING STOCKHOLDER PRIOR TO THE OFFERING IN THE OFFERING ARE SOLD) OFFERING Esquire Trade & Finance Inc. 1,573,685(1)(6) 2,326,316(2) 0 0% Celeste Trust Reg. 1,573,685(1)(6) 2,326,316(2) 0 0% Advantage Fund II Ltd. 2,734,631(3)(6) 75,000(4) 2,659,631(7) 14%(7) Koch Investment Group 908,056(3)(6) 25,000(5) 883,056(7) 4.7%(7) Limited
(1) Represents the number of shares issuable upon conversion of the Series C Convertible Preferred Stock, including two years of accrued dividends thereon, which dividends are payable at our option in common stock, at the initial fixed conversion price of $0.95$0.001 par value per share (the “Common Stock”), of Diffusion Pharmaceuticals Inc. (the “Company”). Of these shares, (a) 12,376,329 are issued and outstanding as well as the exercisea result of, warrants issued to these stockholders in June 2000. (2) In accordance with the Registration Rights Agreement between us and Esquire and Celeste, the number of shares shown as offered by this prospectus represents 200% of the number of shares issuable upon conversion of the Series C Convertible Preferred Stock as described in note (1) plus the shares issuable upon exercise of the related warrants. (3) Represents the number of shares held directly plus the number of sharesor issuable upon, the conversion of the Company’s outstanding shares of Series A Convertibleconvertible preferred stock, $0.001 par value per share (the “Series A Preferred Stock at the initial fixed conversion price”), (b) 13,555,887 are issued and outstanding as a result of, $2.6812, including conversion of two years of accrued dividends thereon, the conversion of Series B Convertible Preferred Stock at the initial fixed conversion price of $1.75, including conversion of two years of accrued dividends thereon, and exercise of warrants issued in connection with the Series A, Series B and Series C Convertible Preferred Stock. The shares issuable upon conversion of the Series A Convertible Preferred Stock and the Series A warrants were previously registered for resale under the Securities Act of 1933 on Registration Statement No. 333-89171. The shares issuable upon conversion of the Series B Convertible Preferred Stock and the Series B warrants were previously registered for resale under the Securities Act of 1933 on Registration Statement 8 13 No. 333-35400. The Series A and B Convertible Preferred Stock and the Series A, Series B and Series C warrants contain a 4.9% beneficial ownership limitation similar to the limitation applicable to the Series C Convertible Preferred Stock described above. (4) Represents sharesor issuable upon, the exercise of warrants issuedto purchase shares of Common Stock (the “Warrants”) and (c) an estimated 535,585 are issuable as payment of dividends accruing through October 1, 2017 with respect to the Series A Preferred Stock. The Selling Stockholders acquired all of the securities covered by this prospectus in connection with the Series C offering. Genesee International, Inc., the investment manager of Advantage Fund II Ltd., may be deemed to beneficially own the shares offered by Advantage through its shared dispositive and voting power over such shares. Mr. Donald R. Morken, the controlling stockholder of Genesee International, may be deemed to control the exercise by Genesee International of such shared dispositive and voting power over such shares. (5) Represents shares issuable upon the exercise of warrants issueda private placement transaction in connection with the Series C offering. Koch Industries, Inc., the indirect parent company of Koch Investment Group Limited, may be deemed to beneficially own the shares offered by Koch Investment Group Limited through its shared dispositive and voting power over such shares. Messrs. Charles Koch and David Koch, the majority stockholders of Koch Industries, may be deemed to control the exercise by Koch Industries of such shared dispositive and voting power over such shares. (6) The actual conversion price will be based on a formula applicable to each series of Convertible Preferred Stock and may be lower than the initial fixed rate. The actual number of shares of common stock issuable upon the conversion of the preferred stock and exercise of the warrants is therefore subject to adjustment and could be materially more than the number estimated in the table. This variation is due to factors that cannot be predicted by us at this time. The most significant of these factors is the future market price of our common stock. (7) These amounts are subject to the 4.9% beneficial ownership limitation described in footnote (3). As of the date of this prospectus, the selling stockholders do not hold any other securities in Titan other than the shares being offered under this prospectus, the Series A Convertible Preferred Stock, the Series B Convertible Preferred Stock, the Series C Convertible Preferred Stock and the warrants described above. None of the selling stockholders has had any material relationship with us within the past three years. DESCRIPTION OF SECURITIES We are authorized to issue up to 90,000,000 shares of common stock and 10,000,000 shares of preferred stock. As of July 15, 2000, 18,769,303 shares of common stock were issued and outstanding. Additionally, as of July 15, 2000, we had outstanding options to purchase 1,285,000 shares of our common stock, warrants to purchase 2,102,573 shares of our common stock, 3,973 shares of our Series A Convertible Preferred Stock, 2,000 shares of our Series B Convertible Preferred Stock and 1,300 shares of our Series C Convertible Preferred Stock. Our Board of Directors has the authority, without further action by the stockholders, to issue a total of up to 9,992,700 additional preferred shares in one or more series and to fix the rights, preferences, privileges and restrictions granted to or imposed upon any series of unissued preferred shares and to determine the number of shares constituting any series and the designation of the series, without any further vote or action by the stockholders. The following summary of certain provisions of the common stock and preferred shares does not purport to be complete and is subject to, and is qualified in its entirety by, our amended Articles of Incorporation, Restated Bylaws, our Certificates of Designations with respect to our Series A, Series B and Series C Convertible Preferred Stock, and by the provisions of applicable law. COMMON STOCK The holders of our common stock are entitled to one vote per share on all matters on which stockholders are entitled to vote. Subject to the rights of holders of any class or series of shares, including preferred shares, having a preference over the common stock as to dividends or upon liquidation, the holders of our common stock 9 14 are also entitled to dividends as may be declared by our Board of Directors out of funds that are lawfully available, and are entitled upon liquidation to receive pro rata the assets that are available for distribution to holders of common stock. Holders of the common stock have no preemptive, subscription, or conversion rights. The common stock is not subject to assessment and has no redemption provisions. SERIES A CONVERTIBLE PREFERRED STOCK We have 3,973 shares of Series A Convertible Preferred Stock authorized, issued and outstanding. The Series A Convertible Preferred Stock is currently convertible at any time into a maximum of 3,429,400 shares of our common stock (unless such limitation is waived by vote of the stockholders) at a fixed conversion price of $2.6812, which represents the average market price of our common stock for the ten days prior to the issuance of the Series A Convertible Preferred Stock on September 17, 1999, the date we sold the Series A Convertible Preferred Stock. Commencing September 17, 2000,Stock and Warrants to accredited investors in closings conducted on March 14, 2017 and March 31, 2017 (or, as applicable, a subsequent donation, pledge or transfer thereof). We are registering the conversion price will be adjusted every six months to be the lesser of (a) 130%resale or other disposition of the prior conversion price or (b) 90%shares of Common Stock to satisfy registration rights we have granted to the Selling Stockholders.

Our registration of the average market price for the ten days prior to such adjustment date. The conversion price is subject to further adjustment under certain other circumstances, including our inability to provide the Series A Convertible Preferred Stockholders with common stock certificates on a timely basis after receiving notice of their conversion, and our failure to pay any applicable redemption price when due. Upon an adjustment of the conversion price, the number of shares into which the Series A Convertible Preferred Stock may be converted is also adjusted. The number of shares of common stock underlyingCommon Stock covered by this prospectus does not mean that the Series A Convertible Preferred Stock is also subject to adjustment for stock splits, stock dividends, combinations, capital reorganizations and similar events relating to our common stock. Dividends at the rate of $60 per annum per share are payable in cashSelling Stockholders will offer or at our option, may be added to the value of the Series A Convertible Preferred Stock subject to conversion and to the $1,000 per share liquidation preference of the Series A Convertible Preferred Stock. We have the right to redeem the Series A Convertible Preferred Stock at a premium, and under some circumstances, at the market price of the common stock into which the Series A Convertible Preferred Stock would otherwise be convertible. The holders of the Series A Convertible Preferred Stock also have the right to require us to redeem all or some of their Series A Convertible Preferred Stock at a premium or at market under the following circumstances: X there is no closing bid price reported for our common stock for five consecutive trading days; X our common stock ceases to be listed for trading on the Nasdaq SmallCap Market; X the holders of our Series A Convertible Preferred Stock are unable, for 30 or more days (whether or not consecutive) to sell their common stock issuable upon conversion of the Series A Convertible Preferred Stock pursuant to an effective registration statement; X we default under any of the agreements relatingshares. The Selling Stockholders(including their donees, pledgees, transferees or other successors-in-interest) may, from time to the sale of the Series A Convertible Preferred Stock; X certain business combination events; X the adoption of any amendment to our Articles of Incorporation materially adverse to the holders of the Series A Convertible Preferred Stock without the consent of the holders of a majority of the Series A Convertible Preferred Stock; and X the holders of the Series A Convertible Preferred Stock are unable to convert all of their shares because of limitations under exchangetime, resell or market rules that require stockholder approval of certain stock issuances. However, the holders of the Series A Convertible Preferred Stock have agreed to amend the terms and conditions of the Series A Convertible Preferred Stock through the filing of an amended and restated certificate of 10 15 designations. The amendments will allow us to deliver a control notice to the Series A holders against their delivery of a redemption notice if the event or circumstances giving rise to the redemption notice were outside of our control. The delivery of a control notice will permit us to adjust the conversion price of the Series A Convertible Preferred Stock in lieu of redemption. Ultimately, this will allow us to classify the Series A Convertible Preferred Stock as equity rather than mezzanine instruments in accordance with generally accepted accounting principles. SERIES B CONVERTIBLE PREFERRED STOCK We have 2,000 shares of Series B Convertible Preferred Stock authorized, issued and outstanding. The Series B Convertible Preferred Stock is currently convertible at any time into a maximum of 3,436,000 shares of our common stock (unless such limitation is waived by vote of the stockholders) at a fixed conversion price of $1.75 per share. Commencing March 9, 2001, the conversion price will be adjusted every six months to be the lesser of (a) the prior conversion price or (b) the average market price for the ten days prior to such adjustment date. The conversion price is subject to further adjustment under certain other circumstances, including our inability to provide the Series B Convertible Preferred Stockholders with common stock certificates on a timely basis after receiving notice of their conversion, and our failure to pay any applicable redemption price when due. Upon an adjustment of the conversion price, the number of shares into which the Series B Convertible Preferred Stock may be converted is also adjusted. The number of shares of common stock underlying the Series B Convertible Preferred Stock is also subject to adjustment for stock splits, stock dividends, combinations, capital reorganizations and similar events relating to our common stock. Dividends at the rate of $60 per annum per share are payable in cash or, at our option, may be added to the value of the Series B Convertible Preferred Stock subject to conversion and to the $1,000 per share liquidation preference of the Series B Convertible Preferred Stock. We have the right to redeem the Series B Convertible Preferred Stock at a premium, and under some circumstances, at the market price of the common stock into which the Series B Convertible Preferred Stock would otherwise be convertible. The holders of the Series B Convertible Preferred Stock also have the right to require us to redeem all or some of their Series B Convertible Preferred Stock at a premium or at market under the following circumstances: X there is no closing bid price reported for our common stock for five consecutive trading days; X our common stock ceases to be listed for trading on the Nasdaq SmallCap Market; X the holders of our Series B Convertible Preferred Stock are unable, for 30 or more days (whether or not consecutive) to sell their common stock issuable upon conversion of the Series B Convertible Preferred Stock pursuant to an effective registration statement; X we default under any of the agreements relating to the sale of the Series B Convertible Preferred Stock; X certain business combination events; X the adoption of any amendment to our Articles of Incorporation materially adverse to the holders of the Series B Convertible Preferred Stock without the consent of the holders of a majority of the Series B Convertible Preferred Stock; and X the holders of the Series B Convertible Preferred Stock are unable to convert all of their shares because of limitations under exchange or market rules that require stockholder approval of certain stock issuances. However, the holders of the Series B Convertible Preferred Stock have agreed to amend the terms and conditions of the Series B Convertible Preferred Stock through the filing of an amended and restated certificate of designations. The amendments will allow us to deliver a control notice to the Series B holders against their delivery 11 16 of a redemption notice if the event or circumstances giving rise to the redemption notice were outside of our control. The delivery of a control notice will permit us to adjust the conversion price of the Series B Convertible Preferred Stock in lieu of redemption. Ultimately, this will allow us to classify the Series B Convertible Preferred Stock as equity rather than mezzanine instruments in accordance with generally accepted accounting principles. SERIES C CONVERTIBLE PREFERRED STOCK We have 2,300 shares of Series C Convertible Preferred Stock authorized, and 1,300 issued and outstanding. The Series C Convertible Preferred Stock is currently convertible at any time into a maximum of approximately 3,500,000 shares of our common stock (unless such limitation is waived by vote of the stockholders) at a fixed conversion price of $0.95. This represents 19.99% of the outstanding common stock of the Company, which is the maximum number of shares of common stock the Company can issue under applicable NASD rules unless such shareholder approval is obtained at an annual or special meeting of stockholders. Commencing December 20, 2000, the conversion price is adjusted every three months to be the lower of (a) 80% of the average market price for the lowest three trading days during the last ten trading days prior to the adjustment date and (b) either (i) the current conversion price if 80% of the average market price is less than or equal to 200% of the current conversion price, or (ii) $0.95 if 80% of the average market price is more than 200% of the current conversion price. The number of shares of common stock underlying the Series C Convertible Preferred Stock is subject to adjustment for stock splits, stock dividends, capital reorganizations and similar events relating to our common stock. Subject to the limit referred to above, the Series C Convertible Preferred Stock converts automatically on the second anniversary of the date of the date of issuance. Following effectiveness of this registration statement we may compel the conversiondispose of any or all of the outstanding Series C Convertible Preferred Stock at the conversion price in effect if for any 20 consecutive trading days both (a) the closing bid price of the common stock of the Company is greater than $1.90 per share, and (b) the average daily trading volume of the common stock is at least 50,000 shares per trading day. However, in no event will the Series C Convertible Preferred Stockholders be required to convert if the number of shares of common stock issuable upon conversion would resultCommon Stock described in beneficial ownership by the Series C Convertible Preferred Stockholder and its affiliates of more than 9.99% of the outstanding shares of common stock of the Company. Dividends at the rate of 5% per annum are payable quarterly or on conversion of the Series C Convertible Preferred Stock in cash or, at our option, in common stock of the Company based on the conversion rate in effect on the relevant date. Subject to certain restrictions in a subordination agreement with our primary lender, Esquire and Celeste each have the right to require us to redeem the Series C Convertible Preferred Stock at a premium upon the occurrence of any of the following events: 1. The amount of common stock reserved for issuance upon conversion of the Series C Convertible Preferred Stock is less than 150% of the number of shares of common stock issuable upon potential conversion of the Series C Convertible Preferred Stock for 10 consecutive trading days and the Company fails to increase the reserved amount above the 150% threshold for 90 days thereafter; 2. The Company is unable to issue sufficient shares of common stock upon conversion of the Series C Convertible Preferred Stock as a result of Nasdaq Rule 4310(c)(25)(H)(i) or Rule 4460(i)(1); or 3. The Company is unable to timely deliver certificates representing the common stock issuable on conversion of the Series C Convertible Preferred Stock. 12 17 WARRANTS We also issued warrants in connection with the offering of our Series A, Series B and Series C Convertible Preferred Stock. We issued warrants to purchase 372,967 shares of common stock to the Series A Convertible Preferred Stockholders, of which 300,000 have been exercised, warrants to purchase 250,000 shares of common stock to the Series B Convertible Preferred Stockholders, all of which remain fully exercisable, and warrants to purchase 1,642,106 shares of common stock to the Series C Convertible Preferred Stockholders, all of which remain fully exercisable. We also issued warrants to purchase 250,000 shares of common stock to Reedland Capital Partners and its designees as partial compensation for their assistance in placing the Series A Convertible Preferred Stock and warrants to purchase 12,500 shares to certain designees of Reedland Capital Partners as partial compensation for their assistance in placing the Series B Convertible Preferred Stock. These warrants remain fully exercisable. The exercise price of the warrants associated with the Series A and Series B transaction have been repriced to $1.00. The exercise price of the warrants issued to the Series C Convertible Preferred Stockholders is $1.69 with respect to five-sixths of the shares and $2.26 with respect to the balance of the shares covered by the warrants. Finally, we issued warrants to purchase 100,000 shares of common stock, at an exercise price of $1.69 per share, to the Series A and Series B Convertible Preferred Stockholders in exchange for their waiver of certain terms and conditions related to the Series C offering. These warrants, representing in the aggregate the right to purchase 2,102,573 shares of common stock, are the only warrants we currently have outstanding. The warrants associated with the Series A transaction expire on September 17, 2004, the warrants associated with the Series B transaction expire on March 9, 2005 and the warrants associated with the Series C transaction expire on June 30, 2005. In no event will holders of the Series C warrants be permitted to exercise if the number of shares of common stock issuable upon exercise would result in beneficial ownership by the holder and its affiliates of more than 9.99% of the outstanding shares of common stock of the Company. In no event will holders of the Series A and Series B Convertible Preferred Stockholders be permitted to exercise their warrants if the number of shares of common stock issuable upon exercise would result in beneficial ownership by the holder and its affiliates of more than 4.99% of the outstanding shares of common stock of the Company. The exercise price and number of shares of common stock issuable upon exercise of the warrants held by the Series A, Series B and Series C Convertible Preferred Stockholders are subject to adjustment in certain events, including events of default that are similar to those described above. TRANSFER AGENT AND REGISTRAR The Transfer Agent and Registrar for our common stock is Signature Stock Transfer, Inc. CHARTER PROVISIONS AND EFFECTS OF NEVADA LAW Our Articles of Incorporation authorize our Board of Directors to issue up to 10,0000,000 shares of preferred stock from time to time in one or more designated series. Our Board of Directors, without approval of the stockholders, is authorized to establish the voting powers, designations, preferences, limitations, restrictions and relative rights of each series of preferred stock, including voting powers, preferences and relative rights that may be superior to our common stock. As of July 18, 2000, 4,000 shares of preferred stock had been designated Series A Convertible Preferred Stock, of which 3,973 shares were outstanding, 2,000 shares of preferred stock had been designated Series B Convertible Preferred Stock, of which 2,000 shares were outstanding and 2,300 shares of preferred stock had been designated Series C Convertible Preferred Stock, of which 1,300 shares were issued and outstanding. Sections 78.3791 through 78.3793 of the Nevada Revised Statutes generally apply to any acquisition of outstanding voting securities of an issuing corporation which results in the acquiror owning more than 20% of the issuing corporation's then outstanding voting securities. An issuing corporation is any Nevada corporation with at least 200 stockholders, at least 100 of which are stockholders of record and Nevada residents, and which conducts business in Nevada. 13 18 The securities acquired in a covered acquisition are denied voting rights unless a majority of the security holders of the issuing corporation approve the granting of voting rights. If permitted by the issuing corporation's Articles of Incorporation or bylaws then in effect, voting securities acquired in the covered acquisition are redeemable by the issuing corporation at the average price paid for the securities by the acquiror if the acquiring person has not given timely notice to the issuing corporation or if the stockholders of the issuing corporation vote not to grant voting rights to the acquiring person's securities. Unless the issuing corporation's Articles of Incorporation or bylaws then in effect provide otherwise, if the acquiring person acquired securities having 50% or more of the voting power of the issuing corporation's outstanding securities and the stockholders of the issuing corporation grant voting rights to the acquiring person, then any stockholders of the issuing corporation who voted against granting voting rights to the acquiring person may demand that the issuing corporation purchase, for fair value, all or any portion of his securities. Our Articles of Incorporation and bylaws do not limit the effect of these provisions. PLAN OF DISTRIBUTION The selling stockholders, their pledgees, donees, transferees or other successors in interest may from time to time offer and sell all or a portion of the shares in transactions on the Nasdaq SmallCap Market, orthis prospectus on any other securitiesstock exchange, market or markettrading facility on which the common stock is listedshares are traded or traded, in private transactions. These sales may be at fixed or negotiated transactions or otherwise, at prices, then prevailing or relatedand may be to the then-current market price or at negotiated prices. The selling stockholders or their pledgees, donees, transferees or other successors in interest may sell their shares directly or through underwriters, broker-dealers or agents, or broker-dealers acting as principal or agent, or in block trades or pursuant to a distribution by one or more underwriters on a firm commitment or best-efforts basis. To the extent required, the names of any agent or broker-dealer and applicable commissions or discounts and any other required information with respect to any particular offer will be set forth in an accompanying prospectus supplement. Each of the selling stockholders and their pledgees, donees, transferees or other successors in interest reserves the right to accept or reject, in whole or in part, any proposed purchase of the shares to be made directly or through agents. Such broker-dealers, if any,who may receive compensation in the form of discounts, concessions or commissions. The Selling Stockholders will pay all underwriting discounts, commissions and any similar expenses it incurs, if any, in connection with the sale of the shares of Common Stock, and any related legal expenses incurred by it. We have agreed to pay certain expenses in connection with this registration statement and to indemnify the Selling Stockholders against certain liabilities. None of our shares of Common Stock may be sold without delivery of the applicable prospectus supplement describing the method and terms of the offering of the Common Stock. See “Plan of Distribution” beginning on page 19 for more information regarding the manners in which Selling Stockholders may sell or dispose of the securities registered hereby.


We are not selling any shares of Common Stock under this prospectus and will not receive any of the proceeds from the sale of shares of Common Stock by the Selling Stockholders. To the extent Warrants are exercised for cash, if at all, we will receive the exercise price thereof.

You should read this prospectus, any applicable prospectus supplement and any related free writing prospectus carefully before you invest.

Our Common Stock is traded on the NASDAQ Capital Market under the symbol “DFFN.” On May 26, 2017, the last reported sale price of our Common Stock was $2.72 per share.

Investing in our Common Stock involves significant risks. See “Risk Factors” on page7 of this prospectus, in our most recent Annual Report on Form 10-K, any of our other filings with the Securities and Exchange Commission and in any applicable prospectus supplement. You should read this prospectus, any accompanying prospectus supplement, and the documents incorporated by reference herein and therein carefully before you make your investment decision.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the Common Stock being offered hereby or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.


This prospectus is dated _________, 2017

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TABLE OF CONTENTS

Page

ABOUT THIS PROSPECTUS

1

PROSPECTUS SUMMARY

2

THE OFFERING6
RISK FACTORS7

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

8

USE OF PROCEEDS

9

THE SELLING STOCKHOLDERS

10

PLAN OF DISTRIBUTION

19

WHERE YOU CAN FIND MORE INFORMATION

22

LEGAL MATTERS

24

EXPERTS

24

PART II   Information Not Required in Prospectus

25


ABOUT THIS PROSPECTUS 

This prospectus is part of a registration statement on Form S-3 that we filed with the U.S. Securities and Exchange Commission, or the Commission, using a “shelf” registration process. Under this process, the Selling Stockholders may from time to time, in one or more offerings, sell the Common Stock described in this prospectus.

You should rely only on the information provided in this prospectus, the related prospectus supplement, including any information incorporated by reference, and any pricing supplement. No one is authorized to provide you with information different from that which is contained, or deemed to be contained, in the prospectus, the related prospectus supplement and any pricing supplement. The Selling Stockholders are not making offers to sell Common Stock in any jurisdiction in which an offer or solicitation is not authorized or in which the person making such offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make an offer or solicitation. You should not assume that the information in this prospectus, any prospectus supplement or any document incorporated by reference is accurate as of any date other than the date of the document in which the information is contained or other date referred to in that document, regardless of the time of sale or issuance of the Common Stock.

This prospectus does not contain all of the information included in the registration statement. For a more complete understanding of the offering of the Common Stock, you should refer to the registration statement including the exhibits. This prospectus contains summaries of certain provisions contained in some of the documents described herein, but reference is made to the actual documents for complete information. All of the summaries are qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have been filed, will be filed or will be incorporated by reference as exhibits to the registration statement of which this prospectus is a part, and you may obtain copies of those documents as described below under the heading “Where You Can Find Additional Information.” We further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference in this prospectus were made solely for the benefit of the parties to such agreement, including in some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.

Unless otherwise specified or unless the context requires otherwise, all references in this prospectus to “Diffusion,” the “Company,” “we,” “us,” “our” or similar references mean Diffusion Pharmaceuticals Inc. and its subsidiaries on a consolidated basis.

We have registered trademarks for RestorGenex and Diffusion. All other trade names, trademarks and service marks appearing in this prospectus are the property of their respective owners. Use or display by us of other parties’ trademarks, trade dress or products is not intended to and does not imply a relationship with, or endorsements or sponsorship of, us by the trademark or trade dress owner.


PROSPECTUS SUMMARY

The following is a summary of what we believe to be the most important aspects of our business and the offering of our common stock under this prospectus. This summary does not contain all of the information that should be considered before investing in our common stock. Investors should read the entire prospectus carefully, including the risks related to our business and purchasing our common stock discussed under “Risk Factors” beginning on page 7 of this prospectus, “Special Notes Regarding Forward Looking Statements” and our financial statements and the notes to those financial statements incorporated by reference in this prospectus.

Diffusion Pharmaceuticals Inc.

Business Overview

We are a clinical stage biotechnology company focused on extending the life expectancy of cancer patients by improving the effectiveness of current standard-of-care treatments, including radiation therapy and chemotherapy. We are developing our lead product candidate,transcrocetinate sodium, also known astrans sodium crocetinate (“TSC”), for use in the many cancer types in which tumor oxygen deprivation (“hypoxia”) is known to diminish the effectiveness of current treatments. TSC is designed to target the cancer’s hypoxic micro-environment, re-oxygenating treatment-resistant tissue and making the cancer cells more susceptible to the therapeutic effects of standard-of-care radiation therapy and chemotherapy.

Our lead development programs target TSC against cancers known to be inherently treatment-resistant, including brain cancers and pancreatic cancer. A Phase 2 clinical program, completed in the second quarter of 2015, evaluated 59 patients with newly diagnosed glioblastoma multiforme (“GBM”). This open label, historically controlled study demonstrated a favorable safety and efficacy profile for TSC combined with standard of care, including a 37% improvement in overall survival over the control group at two years. A particularly strong efficacy signal was seen in the inoperable patients, where survival of TSC-treated patients at two years was increased by 380% over the controls. At an End-Of-Phase 2 Meeting, the U.S. Food and Drug Administration provided Diffusion with extensive guidance on the design for a Phase 3 trial of TSC in newly diagnosed, inoperable GBM patients. We believe focusing on the inoperable patient group in Phase 3 should reduce the needed number of patients from over 400 to around 230, which is expected to provide real cost savings, while the strength of the Phase 2 efficacy signal should make the showing of significant clinical gain in Phase 3 more likely. Assuming FDA sign-off on our final protocol design, focusing on the inoperable patients, the study is planned to initiate by the end of 2017. Due to its novel mechanism of action, TSC has safely re-oxygenated a range of tumor types in our preclinical and clinical studies. Diffusion believes its therapeutic potential is not limited to specific tumors, thereby making it potentially useful to improve standard-of-care treatments of other life-threatening cancers. Additional planned studies include a Phase 2 trial in pancreatic cancer and a study in brain metastases, with a study initiation subject to receipt of additional funding or collaborative partnering. We also believe that TSC has potential application in other indications involving hypoxia, such as neurodegenerative diseases and emergency medicine. For example, our stroke program is now in advanced discussions with doctors from UCLA and the University of Virginia, with whom we have established a joint team dedicated to developing a program to test TSC in the treatment of stroke, with an in-ambulance trial of TSC in stroke under consideration.

In addition to the TSC programs, we are exploring alternatives regarding how best to capitalize upon the legacy RestorGenex product candidate, RES-529, a novel PI3K/Akt/mTOR pathway inhibitor which has completed two Phase I clinical trials for age-related macular degeneration and was in preclinical development in oncology, specifically GBM. RES-529 has shown activity in both in vitro and in vivo glioblastoma animal models and has been demonstrated to be orally bioavailable and can cross the blood brain barrier.

Corporate Information

We are a Delaware corporation. We maintain our principal executive offices at 2020 Avon Court, Suite #4, Charlottesville, VA 22902. Our telephone number there is (434) 220-0718. The address of our website iswww.diffusionpharma.com. The information set forth on, or connected to, our website is expressly not incorporated by reference into, and does not constitute a part of, this prospectus.

-2-

Summary of Private Placement

In March 2017, we conducted a private placement (the “Private Placement”), pursuant to which we issued 12,376,329 shares of the Series A Preferred Stock, initially convertible into one share of Common Stock, and 5-year warrants to purchase 12,376,329 shares of Common Stock at an exercise price equal to $2.22 per share (the “Investor Warrants”). The aggregate gross proceeds from the Private Placement were $25.0 million, prior to deducting placement agent fees and expenses payable by us. Maxim Merchant Capital, a division of Maxim Group LLC (“Maxim”), acted as our sole placement agent in the Private Placement. We issued to Maxim and its designees (who are included as Selling Stockholders) 5-year warrants, to purchase of 1,179,558 shares of Common Stock at an exercise price equal to $2.22 per share, with such warrants containing a cashless exercise provision (the “Maxim Warrants” and, together with the Investor Warrants, the “Warrants”). The securities were issued to accredited investors in reliance upon an exemption pursuant to Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and the rules and regulations promulgated thereunder. Please see “Description of Capital Stock” for a description of our Common Stock, Series A Preferred Stock and Warrants.

As part of the Private Placement, we entered into registration rights agreements with the investors in the Private Placement and Maxim (the “Registration Rights Agreement”), pursuant to which we agreed to file a registration statement to register for resale the shares of common stock (i) issued and outstanding as a result of, or issuable upon, the conversion of the shares of Series A Preferred Stock, (ii) issued and outstanding as a result of, or issuable upon, the exercise of the Warrants sold in the Private Placement and (iii) issuable as payment of dividends accruing on the Series A Preferred Stock. We are required to use our commercially reasonable best efforts to cause the registration statement to be declared effective under the Securities Act, as soon as practicable, but in no event later than 120 days after the final closing of the Private Placement, which occurred on March 31, 2017 (the “Final Closing”). We agreed to keep the registration statement effective until the earlier of (i) 66 months after the Final Closing or (ii) all registrable securities may be sold pursuant to Rule 144 under the Securities Act or another similar exemption under the Securities Act. We also agreed, among other things, to indemnify the investors under the registration statement from certain liabilities and to pay all fees and expenses incident to our performance of or compliance with the Registration Rights Agreement.

Series A Convertible Preferred Stock

Voting. The holders of the Series A Preferred Stock will be entitled to vote with the holders of Common Stock (and any other class or series that may similarly be entitled to vote with the holders of Common Stock as the Board may authorize and issue) and not as a separate class, at any annual or special meeting of stockholders of the Company, and may act by written consent in the same manner as the holders of Common Stock. In the event of any such vote or action by written consent, each holder of shares of Series A Preferred Stock shall be entitled to that number of votes equal to the whole number of shares of Common Stock into which the aggregate number of shares of Series A Preferred Stock held of record by such holder are convertible as of the close of business on the record date fixed for such vote or such written consent based on a conversion price, solely for such purpose, equal to the closing price of our Common Stock on the date such Series A Preferred Stock was issued. In addition, for as long as 50% of the shares of Series A Preferred Stock outstanding immediately after the final closing remain outstanding, without the consent of holders of at least a majority of the then outstanding shares of Series A Preferred Stock, we may not (a) amend our amended and restated certificate of incorporation (the “Certificate of Incorporation”) and amended and restated bylaws (the “Bylaws”)so as to materially and adversely affect any rights of the holders of the Series A Preferred Stock, (b) increase or decrease (other than by conversion of the Series A Preferred Stock) the authorized number of Series A Preferred Stock to be in excess of the number of shares required to satisfy the maximum offering amount of the Private Placement, (c) amend the Certificate of Designation of Preferences, Rights and Limitations of the Series A Convertible Preferred Stock of Diffusion Pharmaceuticals Inc. (the “Certificate of Designation”), (d) repay, repurchase or offer to repay, repurchase or otherwise acquire more than ade minimis number of shares of Common Stock or Common Stock equivalents or (e) enter into any agreement or understanding with respect to (a) through (d).

Dividends. The Series A Preferred Stock will be entitled to an 8.0% cumulative preferred dividend payable semi-annually in shares of Common Stock that will begin accruing on the issue date of the Series A Preferred Stock. The dividend will begin to accrue and be cumulative on the first day of each applicable dividend period and shall remain accumulated dividends with respect to such Series A Preferred Stock until paid; provided, that the first dividend payable with respect to any share of Series A Preferred Stock shall not begin to accrue until the date of original issuance of such share of Series A Preferred Stock. Dividends shall accrue whether or not there are profits, surplus or other funds of the Company legally available for the payment of dividends but shall not be payable until legally permissible, as applicable.

-3-

Liquidation. The Series A Preferred Stock will rank senior to the Common Stock and each other class of capital stock of the Company or series of Series A Preferred Stock of the Company authorized by the Board in the future that does not expressly provide that such class or series ranks senior to, or on parity with, the Series A Preferred Stock (“Junior Securities”). In the event of a Liquidation Event (as defined in the Certificate of Designation), the holders of the Series A Preferred Stock shall be entitled to receive, out of the assets of the Company or proceeds thereof legally available therefor, an amount in cash equal to 100% of the stated value of the Series A Preferred Stock before any payment or distribution of the assets of the Company is made or set apart for the holders of Junior Securities. In addition, prior to such Liquidation Event, the holders of Series A Preferred Stock shall be entitled to notice so that they may exercise their conversion rights prior to such event. If, upon the occurrence of any Liquidation Event, the assets of the Company, or proceeds thereof, distributable after payment in full of our creditors and any securities senior to the Series A Preferred Stock shall be insufficient to pay in full the aggregate amount of 100% of the stated value to the holders of the Series A Preferred Stock, the assets of the Company, or the proceeds thereof, shall be distributed ratably among the holders of any Series A Preferred Stock and the holders of any security ranked equally with the Series A Preferred Stock.

Conversion Rate: Each share of Series A Preferred Stock is convertible into a share of Common Stock at a conversion price equal to the $2.02, subject to adjustment as provided in the Certificate of Designation and summarized herein (the “Conversion Price”), at any time after the final closing date at the holder’s sole and absolute discretion. Holders may immediately convert their Series A Preferred Stock prior to the occurrence of certain Liquidation Events. Each share of Series A Preferred Stock will automatically convert, initially, into a share of Common Stock (a) on any date that is more than thirty (30) trading days after the original issued date of such share Series A Preferred Stock that the 30 day moving average of the closing price of the Common Stock on the NASDAQ Capital Market (or any other exchange where the Common Stock is traded) exceeds $8.00 per share (subject to adjustment in the event of a stock dividend or split), (b) upon a financing of at least $10 million or (c) upon the majority vote of the voting power of the then outstanding shares of Series A Preferred Stock. We are not required to issue any fractional shares of Series A Preferred Stock or Common Stock in connection with the conversion of Series A Preferred Stock and may, in each case, at our discretion, pay the holder such amount in cash or deliver an additional whole share in lieu thereof.

Limitations of Conversion: The number of shares of Common Stock issuable upon a conversion of the Series A Preferred Stock that may be acquired by a holder shall be limited to the extent necessary to ensure that, following such conversion (or other issuance), the total number of shares of Common Stock then beneficially owned by such holder and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the Holder's for purposes of Section 13(d) of the Exchange Act, does not exceed 4.99% of the total number of issued and outstanding shares of Common Stock (including for such purpose the shares of Common Stock issuable upon such conversion). However, any holder may increase or decrease such percentage to any other percentage not in excess of 9.99% of the total number of shares of Common Stock then issued and outstanding provided that such increase in percentage shall not be effective until sixty-one (61) days after notice to the Company.

Dilution Protection. In the event we, at any time after the first date of issue of the Series A Preferred Stock and while at least one share of Series A Preferred Stock is outstanding: (a) pay a dividend or otherwise make a distribution or distributions on shares of its Common Stock or any other equity or equity equivalent securities payable in shares of Common Stock (which, for avoidance of doubt, shall not include any shares of Common Stock issued by the Company upon conversion of the Series A Preferred Stock or any debt securities), (b) subdivide outstanding shares of Common Stock into a larger number of shares, (c) combine (including by way of reverse stock split) outstanding shares of Common Stock into a smaller number of shares or (d) issue by reclassification of shares of Common Stock any shares of capital stock of the Company, then in each case the conversion price shall be multiplied by a fraction of which (x) the numerator shall be the number of shares of Common Stock (excluding treasury shares, if any) outstanding immediately before such event and (y) the denominator shall be the number of shares of Common Stock outstanding immediately after such event. Any adjustment made pursuant to this section shall become effective immediately after the effective date of the applicable event described in subsections (a) through (d) above.

-4-

Make-Whole Adjustment. In the event we, during the three years immediately following the Initial Closing, subject to certain exceptions, issue in an offering at least $10 million of Common Stock or securities convertible into or exercisable for Common Stock at a per share price less than $2.02 (the “Make-Whole Price”), we will be required to issue to the holders of Series A Preferred Stock a number of shares of Common Stock equal to the additional number of shares of Common Stock that such shares of Series A Preferred Stock would be convertible into if the conversion price of the Series A Preferred Stock was equal to 105% of the Make-Whole Price (the “Make-Whole Adjustment”). We are only obligated to issue shares with respect to a Make-Whole Adjustment in the first such subsequent offering, if any, following the Private Placement.

Warrants Issued in the Private Placement

As of May 5, 2017 there were 13,555,887 Warrants issued and outstanding. The Warrants have an exercise price $2.22 per share, are immediately exercisable and are subject to customary anti-dilution adjustments. The Warrants are exercisable until March 31, 2022. The Warrants are subject to a provision prohibiting the exercise of such Warrants to the extent that, after giving effect to such exercise, the holder of such Warrant (together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates), would beneficially own in excess of 19.99% of the outstanding Common Stock. In addition, the Maxim Warrants contain a cashless exercise provision.

-5-

THE OFFERING

Selling Stockholders

Accredited investors who purchased shares of Series A Preferred Stock and Warrants the Private Placement conducted in March 2017, the placement agent for the Private Placement, Maxim, and its designees, and their respective donees, pledges, transferees and other successors-in-interest.

Common Stock offered by

the Selling Stockholders

Subject to adjustment, up to 26,467,801 shares of Common Stock, which includes (a) 12,376,329 shares issued and outstanding as a result of, or issuable upon, the conversion of the Series A Preferred Stock, (b) 13,555,887 shares issued and outstanding as a result of, or issuable upon, the exercise of the Warrants and (c) an estimated 535,585 issuable as payment of dividends accruing through October 1, 2017 with respect to the Series A Preferred Stock.

Use of proceeds

We are not selling any shares of Common Stock under this prospectus and will not receive any of the proceeds from the sale of shares of Common Stock by the Selling Stockholders. To the extent Warrants are exercised for cash, we will receive the exercise price thereof.

Risk factors

Investing in our Common Stock involves a high degree of risk. See “Risk Factors” beginning on page 7 of this prospectus, and any other risk factors described in the documents incorporated by reference in this prospectus or in any accompanying prospectus supplement, for a discussion of factors that you should carefully consider before deciding to invest in our Common Stock.

NASDAQ Capital Market symbol

DFFN

-6-

RISK FACTORS

Investing in our Common Stock involves a high degree of risk. Prior to making any decision to invest in our securities, you should carefully consider the information contained or incorporated by reference in this prospectus or in any accompanying prospectus supplement, including, without limitation, the risks described in our Annual Report on Form 10-K for the fiscal year ended December 31, 2016, which is incorporated herein by reference, the risk factors described under the caption “Risk Factors” in any applicable prospectus supplement and any risk factors set forth in our other filings with the Commission, pursuant to Sections 13(a), 13(c), 14, or 15(d) of the Securities Exchange Act of 1934, as amended, or the Exchange Act, before making an investment decision. The occurrence of any of these risks might cause you to lose all or a part of your investment in the offered securities. See “Where You Can Find More Information.”

-7-

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This prospectus, any applicable prospectus supplement and the documents incorporated by reference herein contain forward-looking statements within the meaning of Section 21E of the Exchange Act and Section 27A of the Securities Act, and are subject to the safe harbor created by those sections. We have identified some of these forward-looking statements with words like “believe,” “may,” “could,” “would,” “might,” “possible,” “potential,” “will,” “should,” “expect,” “intend,” “plan,” “predict,” “anticipate,” “estimate” and “continue”, the negative of these words, other words and terms of similar meaning and the use of future dates. Forward-looking statements involve risks and uncertainties. These uncertainties include factors that affect all businesses as well as matters specific to us. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Uncertainties and risks may cause our actual results to be materially different than those expressed in or implied by our forward-looking statements. For us, particular uncertainties and risks include, among others, our history of operating losses and negative cash flow, uncertainties regarding clinical testing, the difficulty of developing pharmaceutical products, obtaining regulatory and other approvals and achieving market acceptance and other risks and uncertainties described in our filings with the Commission, including:

our estimates regarding expenses, future revenues, capital requirements and needs for additional financing;

our ability to continue as a going concern;

the success and timing of our preclinical studies and clinical trials;

the difficulties in obtaining and maintaining regulatory approval of our products and product candidates, and the labeling under any approval we may obtain;

our plans and ability to develop and commercialize our product candidates;

our failure to recruit or retain key scientific or management personnel or to retain our executive officers;

the accuracy of our estimates of the size and characteristics of the potential markets for our product candidates and our ability to serve those markets;

regulatory developments in the United States and foreign countries;

the rate and degree of market acceptance of any of our product candidates;

our ability to obtain additional financing;

obtaining and maintaining intellectual property protection for our product candidates and our proprietary technology;

our ability to operate our business without infringing the intellectual property rights of others;

recently enacted and future legislation regarding the healthcare system;

the success of competing products that are or become available; and

the performance of third parties, including contract research organizations and manufacturers.

All forward-looking statements in this prospectus, any applicable prospectus supplement and the documents incorporated by reference herein speak only as of the date of this prospectus or any applicable prospectus supplement and are based on our current beliefs and expectations. We undertake no obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as otherwise required by law.

-8-

USE OF PROCEEDS

We will receive no proceeds from the sale of the Common Stock by the Selling Stockholders. To the extent Warrants are exercised for cash, we will receive the exercise price thereof.

The Selling Stockholders will pay any underwriting discounts and commissions and any similar expenses they incur in disposing of the Common Stock, if any, and any related legal expenses incurred by them. We will bear all other costs, fees and expenses incurred in effecting the registration of the Common Stock covered by this prospectus, including all registration and filing fees, fees and expenses of compliance with securities or “blue sky” laws, listing application fees, printing expenses, transfer agent’s and registrar’s fees, costs of distributing prospectuses in preliminary and final form as well as any supplements thereto, and fees and disbursements of counsel for the Company and all independent certified public accountants and other persons retained by the Company.

-9-

THE SELLING STOCKHOLDERS

This prospectus relates to the resale or other disposition from time to time by the Selling Stockholders identified herein (including their donees, pledgees, transferees or other successors-in-interest) of, subject to adjustment, up to26,467,801shares of Common Stock. Of these shares, (a) 12,376,329 are issued and outstanding as a result of, or issuable upon, the conversion of the Series A Preferred Stock, (b) 13,555,887 are issued and outstanding as a result of, or issuable upon, the exercise of the Warrants (including the Maxim Warrants) and (c) an estimated 535,585 are issuable as payment of dividends accruing through October 1, 2017 with respect to the Series A Preferred Stock. We entered into subscription agreements on March 14, 2017 and March 31, 2017 for the sale of an aggregate of 12,376,329 shares of the Series A Preferred Stock for aggregate gross proceeds of approximately $25.0 million in the Private Placement to the investors therein. In addition, each such investor received a Warrant to purchase one share of Common Stock for each share of Series A Preferred Stock purchased by such investor in the Private Placement. In connection with the Private Placement, we entered into the Registration Rights Agreement with such investors. The filing of the registration statement of which this prospectus is a part is pursuant to our obligations to register the shares of Common Stock on behalf of the Selling Stockholders under the Registration Rights Agreement. All expenses incurred with the registration of the Common Stock owned by the Selling Stockholders will be borne by us. This prospectus will not cover subsequent sales of Common Stock purchased from a Selling Stockholder named in this prospectus.

We cannot predict when or whether any of the Selling Stockholders will convert their Series A Preferred Stock or exercise their Warrants and even if they do, we do not know how long the Selling Stockholders will hold the shares of Common Stock acquired upon conversion or exercise, as applicable, before selling them, and we currently have no agreements, arrangements or understandings with the Selling Stockholders regarding the sale or other disposition of any of the shares. The shares of Common Stock covered hereby may be offered from time to time by the Selling Stockholders.

Furthermore, we do not know when or in what amounts the Selling Stockholders may sell or otherwise dispose of the shares covered hereby. The Selling Stockholders might not sell any or all of the shares covered by this prospectus or may sell or dispose of some or all of the shares other than pursuant to this prospectus. Because the Selling Stockholders may not sell or otherwise dispose of some or all of the shares covered by this prospectus and because there are currently no agreements, arrangements or understandings with respect to the sale or other disposition of any of the shares, we cannot estimate the number of the shares that will be held by the Selling Stockholders after completion of the offering. For purposes of the table below, we have assumed that the Selling Stockholders will have sold all of the shares covered by this prospectus upon completion of the applicable offering.

The table below presents information regarding the Selling Stockholders and the shares of our Common Stock that they may sell or otherwise dispose of from time to time under this prospectus. The percentage of beneficial ownership is based upon 10,345,637 shares of Common Stock issued and outstanding as of May 5, 2017. Beneficial ownership is determined under Section 13(d) of the Exchange Act and generally includes voting or investment power with respect to securities and includes any securities that grant the Selling Stockholders the right to acquire Common Stock within 60 days of May 5, 2017. Information in the table below is based on information provided by or on behalf of the Selling Stockholders. Since the date on which they provided us with the information below, the Selling Stockholders may have sold, transferred or otherwise disposed of some or all of the shares in transactions exempt from the registration requirements of the Securities Act.

-10-

Name of Selling Stockholders(1)

 

Shares of Common Stock
Beneficially Owned

Before this Offering(2)

  

Estimated

Shares of

Common

Stock to be

Issuable as

Dividends

on the

Series A

Preferred

Stock at

10/1/2017

  

Number of

Shares of

Common

Stock Being

Offered

Pursuant to

this

Prospectus(3)

  

Shares of Common Stock

Beneficially To Be Owned

Upon Completion of this

Offering(4)

 
  

Number

  

Percentage(5)

  

Number

  

Number

  

Number

  

Percentage(5)

 

ABG – USL1 Limited(6)

  1,127,182   9.9

%

  21,210   970,892   177,500   1.7

%

ACNYC, LLC

  607,550   4.6

%

  11,056   506,106   112,500   1.1

%

Adam Lipson

  99,010   *   2,211   101,221       

Adam T Drobot & Lucy S. Drobot JT Ten

  27,254   *   553   25,307   2,500   * 

Adolfo Carmona & Donna Carmona JT TEN

  93,170   *   1,857   85,027   10,000   * 

Advanced Ambulatory ANES LLC Defined Benefit Plan

  272,526   2.6

%

  5,528   253,054   25,000   * 

Albert Gentile & Heidi Lyn Gentile JT TEN

  41,604   *   884   40,488   2,000   * 

Alva Terry Staples

  24,952   *   557   25,509       

Alyson D. Schlosser

  37,154   *   774   35,428   2,500   * 

Andrew Schwartzberg

  455,446   4.2

%

  9,311   464,757       

Andy Entertainment Limited

  49,506   *   1,106   50,612       

Angelo Moesslang & Monika Moesslang JT TEN

  69,308   *   1,548   70,856       

Anthony Daulerio

  49,506   *   1,106   50,612       

AR Properties C/O Dennis Repp

  300,196   2.9

%

  3,354   153,550   150,000   1.4

%

Arnold E. Spangler

  101,510   *   2,211   101,221   2,500   * 

Arnold T Hagler Separate Trust U/A/D 9/17/97 Arnold T Hagler TTEE

  27,754   *   553   25,307   3,000   * 

Barclay Armitage

  89,160   *   1,880   86,040   5,000   * 

Ben Crown

  208,020   1.3

%

  4,422   202,442   10,000   * 

Benjamin King

  24,754   *   506   25,260       

Benjamin L. Padnos

  160,398   1.5

%

  3,279   163,677       

Benjamin R. Hasty

  27,254   *   506   25,260   2,500   * 

BES Investments, LLC

  133,812   1.3

%

  2,653   121,465   15,000   * 

Bigger Capital Fund, L.P.

  247,600   2.3

%

  5,062   252,662       

Bowling Family Trust

  55,446   *   1,238   56,684       

Bradley Cuvelier

  99,010   *   2,211   101,221       

Brian Potiker Revocable Trust UAD 8/7/96 Brian Potiker TTEE

  62,006   *   1,012   50,518   12,500   * 

 -11-

Bruce D. Goethe & Laura K. Goethe COMM PROP WROS

  30,224   *   619   28,343   2,500   * 

Bruce Inglis & Nancy Inglis JT TEN

  27,254   *   553   25,307   2,500   * 

Bryan Ezralow 1994 Trust UTD 12/22/1994 U/A/D 12/22/94 Bryan Ezralow TTEE AMD 12/01/12

  198,020   1.9

%

  4,422   202,442       

C. Barnes Darwin II

  99,110   *   1,990   91,100   10,000   * 

Carleen Tufo DTD 2/21/2017

  27,254   *   553   25,307   2,500   * 

Charles Brinkley

  27,254   *   506   25,260   2,500   * 

Chitayat Holdings, LLC

  99,010   *   2,211   101,221       

Ciro Giuseppe Randazzo

  49,506   *   1,012   50,518       

CJ Biotech II, LLC

  222,774   2.1

%

  4,554   227,328       

Clay Struve

  109,010   1.0

%

  2,211   101,221   10,000   * 

Craig Geers

  38,154   *   708   35,362   3,500   * 

Daniel P. Petro

  32,254   *   553   25,307  

7,500

   * 

David Abel

  29,704   *   663   30,367       

David Abraham & Joann Abraham JT TEN

  133,714   1.2

%

  2,875   131,589   5,000   * 

David D. Shively Rev Wealth Preservation Trust UAD 7/21/04 David D. Shively TTEE

  99,010   *   2,211   101,221       

David E. Schwartz

  83,708   *   1,548   70,856   14,400   * 

David E.I. Pyott Revocable Living Trust U/A/D 4/18/14 David E.I. Pyott TTEE

  495,050   4.6

%

  10,121   505,171       

David Frydrych

  505,546   4.7

%

  9,109   454,655   60,000   * 

David G. Schmidt

  1,169,643   10.6

%

  14,373   657,939   526,077   4.9

%

David Pouland

  99,010   *   2,211   101,221       

David R. Victor Revocable Trust UAD 3/29/00 David R. Victor TTEE

  54,506   *   1,106   50,612   5,000   * 

David S. Nagelberg 2003 Rev TR U/A/D 07/02/03 David S. Nagelberg TTEE A/M/D 12/11/07

  247,526   2.3

%

  5,528   253,054       

David Schneider

  218,020   2.1

%

  4,422   202,442   20,000   * 

David Y. Norton

  49,704   *   663   30,367   20,000   * 

David Young & Karen Plaisance JT TEN

  49,506   *   1,106   50,612       

Dennis Shasha

  114,010   1.1

%

  2,211   101,221   15,000   * 

DJ&J, LLC

  218,020   2.1

%

  4,422   202,442   20,000   * 

Dominick Abel TOD

  38,154   *   774   35,428   3,500   * 

Donald E. Hinkle

  32,664   *   662   30,326   3,000   * 

Donald Sesterhenn

  24,754   *   553   25,307       

Douglas J. Gold

  24,754   *   506   25,260       

Dyke Rogers

  207,920   2.0

%

  4,422   202,442   9,900   * 

-12- 

E.L. Property Trust UAD 7/01/83 Robert C. Kopple TTEE

  990,100   8.7

%

  22,112   1,012,212       

Edgar D. Jannotta JR Exempt Family Trust U/A/D 10/02/1998 Erika Pearsall TTEE

  247,526   2.3

%

  5,061   252,587       

Eldar Investments, LLC

  24,754   *   506   25,260       

Elevado Investments Company, LLC

  208,020   2.0

%

  4,422   202,442   10,000   * 

Eric Prescott Campbell

  44,556   *   911   45,467       

Erick Richardson

  148,516   1.4

%

  3,036   151,552       

Ernest W. Moody Revocable Trust U/A/D 01/14/09 Ernest W. Moody TTEE

  1,215,100   10.7

%

  20,242   1,010,342   225,000   2.1

%

EZ Colony Partners, LLC

  208,020   2.0

%

  4,422   202,442   10,000   * 

EZ MM & B Holdings, LLC

  208,020   2.0

%

  4,422   202,442   10,000   * 

G. Jan Van Heek

  27,254   *   553   25,307   2,500   * 

Garfinkle Revocable Trust UAD 5/15/08 Morris Garfinkle & Stephanie Garfinkle TTEES

  106,510   1.0

%

  2,211   101,221   7,500   * 

Gary M. Ferman

  35,625   *   613   30,613   5,625   * 

Gary W. Jaster

  55,446   *   1,238   56,684       

Graham Burton

  990,100   8.7

%

  20,242   1,010,342       

Graham R. Smith

  54,506   *   1,106   50,612   5,000   * 

Greenway Capital, L.P.

  198,020   1.9

%

  4,048   202,068       

Gregory L. Storm

  123,764   1.2

%

  2,530   126,294       

Henry Herzing Revocable Living Trust U/A/D 10/27/93 Henry Herzing TTEE AMD 05/22/00

  475,842   4.4

%

  9,287   425,129   60,000   * 

Howard J. Worman

  27,254   *   553   25,307   2,500   * 

IRA FBO Kristian Weinman Pershing LLC as Custodian Roth

  20,000   *   409   20,409       

IRA FBO Marhsall S Ezralow Pershing LLC as Custodian Roth Account

  208,020   2.0

%

  4,422   202,442   10,000     

IRA FBO Robin J. Steele Pershing LLC as Custodian Rollover Account

  99,010   *   2,024   101,034       

IRA FBO Stephen R. Meyer Pershing LLC as Custodian Rollover Account

  98,110   *   1,990   91,100   9,000   * 

IRA FBO Steven Yost Pershing LLC as Custodian Roth Conversion Account #2

  29,664   *   662   30,326       

 -13-

IRA FBO: Peter J. Spengler Pershing LLC as Custodian

  99,010   *   2,211   101,221       

IRA FBO: Roger L. Hawley Pershing LLC as Custodian

  198,020   1.9

%

  4,422   202,442       

Irrevocable Aloha Trust UAD 5/1/02 Marianne Schmitt Hellauer TTEE

  198,020   1.9

%

  4,422   202,442       

Irwin Blitt Revocable Trust UAD 1/28/78 Irwin Blitt TTEE AMD 1/11/07

  54,506   *   1,106   50,612   5,000   * 

Isymax Corp

  22,000   *   491   22,491       

Jack Cavin Holland 1979 Trust U/A/D 2/14/79 Jack Cavin Holland TTEE

  49,506   *   1,012   50,518       

Jack R. Frank II

  27,254   *   506   25,260   2,500   * 

Jacob D. Wiznitzer

  34,654   *   708   35,362       

James A. Kluge

  31,754   *   553   25,307   7,000   * 

James B. and Karen A Glavin Family Trust U/A/D 10/30/98 James B. and Karen A. Glavin TTEES

  54,506   *   1,106   50,612   5,000   * 

James Diasio

  33,724   *   619   28,343   6,000   * 

James F. Winschel, JR

  49,506   *   1,106   50,612       

James L. Dritz

  36,496   *   681   31,177   6,000   * 

James L. Payne & Arlene H. Payne TEN COMM

  247,526   2.3

%

  5,528   253,054       

James R. Hollingshead and Amita Hollingshead Revocable Living Trust 5/30/08 James and Amita Hollingshead TTEES

  49,506   *   1,012   50,518       

James W. Thomas

  11,402   *   202   10,104   1,500   * 

Jason Schmidt

  49,506   *   1,106   50,612       

Jay & Jennifer Ferguson JT TEN

  99,010   *   2,024   101,034       

Jayant Aphale

  99,010   *   2,024   101,034       

Jeff Kurtz

  27,254   *   553   25,307   2,500   * 

Jeffrey & Margaret Padnos 2010 Generation Trust F/B/O Benjamin Padnos

  50,000   *   1,022   51,022       

Jeffrey Bacha

  24,750   *   506   25,256       

Jeffrey S. Padnos & Margaret Mais Padnos JT TEN

  100,000   *   2,044   102,044       

Jeffrey Wren & Shannon Wren TEN COMM

  24,754   *   506   25,260       

Joel L. Hochman Revocable Trust UAD 12/08/94 Joel L. Hochman TTEE

  81,758   *   1,658   75,916   7,500   * 

Joel Yanowitz

  19,802   *   405   20,207       

 -14-

John Florsheim

  24,754   *   553   25,307       

John Ford

  24,754   *   506   25,260       

John V. Wagner

  54,506   *   1,106   50,612   5,000   * 

Jonathan Gilliland

  29,802   *   405   20,207   10,000   * 

Jonathan Patronik

  25,600   *   470   23,470   2,600   * 

Joshua Gregg Berkowitz

  148,516   1.4

%

  3,317   151,833       

Juan Carlos Alzate Tejada

  49,506   *   1,106   50,612       

Juli-Ann Cialone

  15,248   *   341   15,589       

Karen Shasha

  24,754   *   553   25,307       

Keith Gelles

  163,516   1.6

%

  3,317   151,833   15,000   * 

Keller Enterprises, LLC

  695,050   6.4

%

  10,121   505,171   200,000   1.9

%

Kenmont Capital Private Equity Partners III

  148,516   1.4

%

  3,317   151,833       

Kenneth F. Buechler Trust 9/24/2007 UAD 9/24/07 Kenneth F. Buechler TTEE

  24,754   *   506   25,260       

Kevin Gabrik

  19,802   *   405   20,207       

Lambda IV, LLC

  247,526   2.3

%

  5,528   253,054       

Leonite Capital, LLC

  74,258   *   1,518   75,776       

Leslie Rudes Grandchildren Trust UAD 2/27/03 Lis Rudes Sandel TTEE

  260,026   2.5

%

  5,061   252,587   12,500   * 

Leipman Trust UAD 5/08/1984 Holger A Liepmann & Loraine Liepmann TTEES AMD 4/22/12

  44,556   *   957   45,513       

Lisa Rudes Grandchildren Trust UAD 2/13/03 Lis Rudes Sandel TTEE

  260,026   2.5

%

  5,060   252,586   12,500   * 

Loeb Holding Corporation

  99,010   *   2,211   101,221       

Louis Vigden

  109,010   *   2,024   101,034   10,000   * 

Lundring Family Trust U/A/D 2/13/02 Eric Lundring and Lori Yost Lundring TTEES

  29,704   *   663   30,367       

Mai 2, LLC

  346,536   3.2%  7,739   354,275       

Marc Cohen

  39,904   *   774   35,428   5,250   * 

Marc R. Jalbert

  49,506   *   1,106   50,612       

Mark Grinbaum and Tatyana Grinbaum JT TEN

  74,308   *   1,548   70,856   5,000   * 

Mark H. Rubin

  64,358   *   1,316   65,674       

Mark Ravich

  24,754   *   506   25,260       

Marsha K. Ederer

  74,258   *   1,518   75,776       

Mayhar Eidgah

  24,754   *   553   25,307       

Maxim Merchant Capital(7)

 

1,377,695

  

4.9

     1,179,558  

198,137

  

1.9

Michael Cohn & Paula Cohn JT TEN

  27,452   *   557   25,509   2,500   * 

Michael P. Ross

  203,020   1.9

%

  4,422   202,442   5,000   * 

 -15-

Monte D. Anglin & Janet S. Anglin JT TEN

  27,254   *   553   25,307   2,500   * 

Neil H. Wasserman

  29,704   *   663   30,367       

OSI Holdings, LLC

  29,754   *   553   25,307   5,000   * 

OSPREY I, LLC

  81,758   *   1,658   75,916   7,500   * 

Panella Living Trust U/A/D 05/11/04 Joseph Panella and Pan Panella TTEES

  14,144   *   260   11,904   2,500   * 

Patrick Lin

  49,506   *   1,012   50,518       

Peter B. Rauenbuehler & Mary L. Mines Living Trust U/A/D 09/26/05 Peter B. Rauenbuehler & Mary MinesTTEES

  99,802   *   2,229   102,031       

Peter D. Schiffrin

  49,506   *   1,106   50,612       

Peter john Freix

  24,754   *   506   25,260       

Pura Vida Master Fund, LTD

  165,632   1.6

%

  3,386   169,018       

Rande R Willison

  29,754   *   506   25,260   5,000   * 

Richard D. Cohen

  150,892   1.4

%

  2,477   113,369   40,000   * 

Richard Dvorak

  29,324   *   619   28,343   1,600   * 

Richard F. Braun

  115,010   1.1

%

  2,211   101,221   16,000   * 

Richard Martin Reiter

  27,254   *   553   25,307   2,500   * 

Richman Trust DTD 6/02/1983 UAD 6/02/83 Douglas Richman & Eva Richman TTEES AMD 1/6/14

  29,704   *   663   30,367       

Rick D. Mace & Karen Mace JT TEN

  34,654   *   774   35,428       

Robert C. Monks

  26,000   *   409   20,409   6,000   * 

Robert Charles Bourge

  109,010   1.0

%

  2,211   101,221   10,000   * 

Robert Giesen

  13,402   *   221   10,123   3,500   * 

Robert Kantor

  54,506   *   1,106   50,612   5,000   * 

Robert N Garff

  57,050   *   1,166   58,216       

Robin J. Steele Trust DTD 1/30/2015 Robin J. Steele TTEE AMD 05/04/15

  99,010   *   2,211   101,221       

Robin Rothstein & Jeffery Rothstein COMM PROP WROS

  49,506   *   1,106   50,612       

Ron Eller & Beth Eller JT TEN

  32,724   *   619   28,343   5,000   * 

RP Capital, LLC

  455,446   4.2

%

  9,311   464,757       

Russell Nowak

  49,506   *   1,012   50,518       

Russell S. Dritz

  9,518   *   186   8,504   1,200   * 

Ryan Miller & Gail Miller

  29,704   *   663   30,367       

Sean Janzer

  24,754   *   553   25,307       

Shamus, LLC

  489,132   4.6

%

  5,765   263,897   231,000   2.2

%

Sherry Casali

  24,754   *   506   25,260       

Shiloh Produce, Inc.

  191,388   1.8

%

  3,913   195,301       

Stanley M. Marks

  54,506   *   1,106   50,612   5,000   * 

Stephen Bender

  109,010   1.0

%

  2,211   101,221   10,000   * 

 -16-

Stephen Dwayne Richards

  49,506   *   1,106   50,612       

Stephen J. Meringoff

  495,050   4.6

%

  10,121   505,171       

Stephen M. Payne

  59,506   *   1,106   50,612   10,000   * 

Stephen Mut

  24,754   *   553   25,307       

Steve Goodman & Helane Goodman JT TEN

  39,604   *   884   40,488       

Steven and Kaye Yost Family Trust U/A/D 02/07/92 AMD 6/04/97 Steven A. Yost and Kate Yost TTEES

  59,902   *   1,114   51,016   10,000   * 

Steven F. White

  51,393   *   531   26,521   25,403   * 

Steven Glassman

  27,254   *   553   25,307   2,500   * 

Steven H. Oram Revocable Trust UAD 5/17/06 Steven H. Oram & Terri Oram TTEES

  54,506   *   1,106   50,612   5,000   * 

Steven K. Luminais & Elizabeth Kindwall Luminais JT TEN

  54,506   *   1,106   50,612   5,000   * 

Steven M. Nelson

  26,827   *   557   25,509   1,875   * 

Swift Run Capital

  990,100   8.7

%

  22,112   1,012,212       

Terrence E. Troy

  86,210   *   1,769   80,979   7,000   * 

The A.C. Trust (Delaware) UAD 8/21/08 Seth Lapidow TTEE

  495,050   4.6

%

  11,056   506,106       

The Bahr Family Limited Partnership

  119,912   1.1

%

  2,432   111,344   11,000   * 

The Kentor Trust U/A/D 9/18/02 Eric Kentor and Adrienne Kentor TTEES

  24,754   *   553   25,307       

The Notas Family Trust UAD 8/13/1997 Bernard Notas & Eve Notas TTEES

  69,308   *   1,548   70,856       

The Oberkfell Living Trust U/A/D 12/18/02 HF Oberkfell & VA Oberkfell TTEES AMD 06/29/10

  55,446   *   1,238   56,684       

The R Scott Greer and Michelle Greer Revocable Trust U/A/D 10/01/00 R. Scott Greer and Michelle Greer TTEES

  49,506   *   1,106   50,612       

The Robert L. Bahr Revocable Trust UAD 3/14/85 Robert Bahr TTEE

  89,110   *   1,990   91,100       

The Stanford Baratz Revocable Trust U/A/D 09/07/94 Stanford Baratz & Amy Baratz TTEES

  21,875   *   409   20,409   1,875   * 

Thomas L. Eisenberg

  28,754   *   553   25,307   4,000   * 

Thomas L. Kempner

  99,010   *   2,211   101,221       

Thomas M Vertin

  49,506   *   1,012   50,518       

Timothy Michael Cicchese

  99,010   *   2,211   101,221       

Timothy P. Hanley & Monica Hanley JTWROS

  99,010   *   2,211   101,221       

Tom Sego

  99,010   *   2,024   101,034       

Trust of David Benaderet U/A/D 1/15/13 David Benaderet TTEE

  54,506   *   1,106   50,612   5,000   * 

Trust U/W Renee Weiss DTD 5/9/90 Peter H. Weiss TTEE

  23,552   *   442   20,244   3,750   * 

William Filon

  21,802   *   442   20,244   2,000   * 

William H. Costigan

  24,754   *   506   25,260       

William Huff

  51,956   *   1,105   50,561   2,500   * 

William Kadi & Sandra Marie Kadi JT TEN

  24,754   *   506   25,260       

William Krywicki & Nancie Krywicki JT TEN

  49,506   *   1,106   50,612       

William Strawbridge

  24,754   *   553   25,307       

Wilson Wilson & Wilson

  44,556   *   910   45,466       

Zhe Qiu

  99,012   *   2,117   101,129       

-17-


* Less than 1%

(1)

All information contained as of May 5, 2017.

(2)

Includes (a) shares of our Common Stock held by the applicable Selling Stockholder, (b) shares of Common Stock issuable upon exercise or conversion of convertible securities that are currently exercisable or convertible or are exercisable or convertible within 60 days of May 5, 2017 beneficially owned by the applicable Selling Stockholder outside of the Private Placement and (c) shares of Common Stock issuable to the applicable Selling Stockholder upon the conversion of the Series A Preferred Stock or the exercise of the Warrants sold in the Private Placement.

(3)

Consists only of (a) shares of Common Stock issuable to the applicable Selling Stockholder upon the conversion of the Series A Preferred Stock or the exercise of the Warrants sold in the Private Placement and (b) shares of Common Stock issuable to the applicable Selling Stockholder as dividends on the Series A Preferred Stock.

(4)

For purposes of this table, the Company assumes that all of the shares covered by this prospectus will be sold by the Selling Stockholders.

(5)

Based on a denominator equal to the sum of (a) 10,345,637 shares of our Common Stock outstanding on May 5, 2017, and (b) the number of shares of Common Stock issuable upon exercise or conversion of convertible securities that are currently exercisable or convertible or are exercisable or convertible within 60 days of May 5, 2017 beneficially owned by the applicable Selling Stockholder.

(6)

Shares beneficially owned is based solely on the Schedule 13G/A filed with the SEC on April 6, 2017 by Ally Bridge Group Capital Partners II, L.P. (“Ally Bridge”). The address of Ally Bridge is Unit 3002-3004, 30th Floor, Gloucester Tower, The Landmark, 15 Queen’s Road Central, Hong Kong. Amounts reported do not include 6,099 shares of Common Stock held by ABG II - SO Limited, as reported on the Schedule 13G/A filed with the SEC on April 6, 2017 by Ally Bridge. The conversion of the Series A Preferred Stock and the exercise of certain warrants held by this Selling Stockholder are subject to a 9.99% ownership blocker.

(7)

Maxim Merchant Capital, a division of Maxim Group LLC, a FINRA member broker-dealer, acted as our sole placement agent in the Private Placement. In connection with the Private Placement, we issued to Maxim and its designees 5-year warrants to purchase of 1,179,558 shares of Common Stock at an exercise price equal to $2.22 per share, with such warrants containing a cashless exercise provision. The exercise of certain warrants held by this Selling Stockholder are subject to a 4.99% ownership blocker.

Each time the Selling Stockholders sell any shares of Common Stock offered by this prospectus, they are required to provide you with this prospectus and the related prospectus supplement, if any, containing specific information about the Selling Stockholders and the terms of the shares of Common Stock being offered in the manner required by the Securities Act.

No offer or sale may occur unless the registration statement that includes this prospectus has been declared effective by the Commission and remains effective at the time the Selling Stockholders offer or sell shares of Common Stock. We are required, under certain circumstances, to update, supplement or amend this prospectus to reflect material developments in our business, financial position and results of operations and may do so by an amendment to this prospectus, a prospectus supplement or a future filing with the Commission incorporated by reference in this prospectus.

This prospectus also covers any additional shares of Common Stock that become issuable in connection with the shares being registered by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of our outstanding shares of Common Stock.

-18-

PLAN OF DISTRIBUTION

We are registering the shares of Common Stock issuable to the Selling Stockholders upon conversion of the Series A Preferred Stock or exercise of the Warrants issued to the Selling Stockholders to permit the resale of these shares of Common Stock by the holders thereof from time to time after the date of this prospectus, pursuant to the provisions of the Registration Rights Agreement. As used in this prospectus, “Selling Stockholders” includes donees, pledgees, transferees or other successors-in-interest selling shares received after the date of this prospectus from a selling stockholder as a gift, pledge, partnership distribution or other permitted transfer.

We will not receive any of the proceeds from the sale by the Selling Stockholders of the shares of Common Stock. We will bear all fees and expenses incident to our obligation to register the shares of Common Stock.

The Selling Stockholders may sell all or a portion of the shares of Common Stock beneficially owned by them and offered hereby from time to time directly or through one or more underwriters, broker-dealers or agents. If the shares of Common Stock are sold through underwriters or broker-dealers, the Selling Stockholders will be responsible for underwriting discounts, commissions or any similar expenses it incurs in disposing of the Common Stock, if any, and any related legal expenses incurred by it. The shares of Common Stock may be sold on any national securities exchange or quotation service on which the securities may be listed or quoted at the time of sale, in the over-the-counter market or in transactions otherwise than on these exchanges or systems or in the over-the-counter market and in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale, or at negotiated prices. These sales may be effected in transactions, which may involve crosses or block transactions. In addition, the Selling Stockholders may use any one or more of the following methods when selling shares:

ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;

block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction;

purchases by a broker-dealer as principal and resale by the broker-dealer for its account;

an exchange distribution in accordance with the rules of the applicable exchange;

privately negotiated transactions;

settlement of short sales entered into after the effective date of the registration statement of which this prospectus is a part;

broker-dealers may agree with the Selling Stockholders to sell a specified number of such shares at a stipulated price per share;

through the writing or settlement of options or other hedging transactions, whether such options are listed on an options exchange or otherwise;

a combination of any such methods of sale; and

any other method permitted pursuant to applicable law.

The Selling Stockholders also may resell all or a portion of the shares in open market transactions in reliance upon Rule 144 under the Securities Act, as permitted by that rule, or Section 4(a)(1) under the Securities Act, if available, rather than under this prospectus, provided that they meet the criteria and conform to the requirements of those provisions.

-19-

Broker-dealers engaged by the Selling Stockholders may arrange for other broker-dealers to participate in sales. If the Selling Stockholders effect such transactions by selling shares of Common Stock to or through underwriters, broker-dealers or agents, such underwriters, broker-dealers or agents may receive commissions in the form of discounts, concessions or commissions from the selling shareholder and/Selling Stockholders or thecommissions from purchasers of the shares of common stockCommon Stock for whom such broker-dealersthey may act as agentsagent or to whom they may sell as principals, or both (which compensation,principal. Such commissions will be in amounts to be negotiated, but, except as set forth in a particular broker-dealer, mightsupplement to this prospectus, in the case of an agency transaction will not be in excess of a customary commissions). brokerage commission in compliance with FINRA Rule 2121; and in the case of a principal transaction a markup or markdown in compliance with FINRA Rule 2121.01.

In connection with distributionssales of the shares any selling stockholderof Common Stock or otherwise, the Selling Stockholders may enter into hedging transactions with broker-dealers and the broker-dealersor other financial institutions, which may in turn engage in short sales of the shares of Common Stock in the course of hedging thein positions they assume with the selling stockholder. Any selling stockholderassume. The Selling Stockholders may also may sell the shares of Common Stock short and if such short sale shall take place after the date that this Registration Statement is declared effective by the Commission, the Selling Stockholders may deliver the shares of Common Stock covered by this prospectus to close out short positions and to return borrowed shares in connection with such short positions. Any selling stockholdersales. The Selling Stockholders may also loan or pledge shares of Common Stock to broker-dealers that in turn may sell such shares, to the extent permitted by applicable law. The Selling Stockholders may also enter into option or other transactions with broker-dealers that involveor other financial institutions or the creation of one or more derivative securities which require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction). Notwithstanding the foregoing, the Selling Stockholders have been advised that they may not use shares registered on this registration statement to cover short sales of our common stock made prior to the date the registration statement, of which this prospectus forms a part, has been declared effective by the Commission.

The Selling Stockholders may, from time to time, pledge or grant a security interest in some or all of the Warrants or shares toof Series A Preferred Stock or Common Stock owned by them and, if they default in the broker-dealers, whichperformance of their secured obligations, the pledgees or secured parties may then resell or otherwise transfer such shares. Any selling stockholder also may loan or pledge the shares to a broker-dealeroffer and the broker-dealer may sell the shares so loanedof Common Stock from time to time pursuant to this prospectus or upon a default may sellany amendment to this prospectus under Rule 424(b)(3) or otherwise transfer the pledged shares. The activities are limited by the purchase agreement between us and the selling stockholders during periods when the conversion price is subject to periodic adjustment. The selling stockholders, any agents, dealers or underwriters that participate with the selling stockholders in the resaleother applicable provision of the sharesSecurities Act amending, if necessary, the list of common stock andSelling Stockholders to include the pledgees, donees, transfereespledgee, transferee or other successors in interest as Selling Stockholders under this prospectus. The Selling Stockholders also may transfer and donate the shares of Common Stock in other circumstances in which case the transferees, donees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus.

The Selling Stockholders and any broker-dealer or agents participating in the distribution of the selling stockholdersshares of Common Stock may be deemed to be "underwriters"“underwriters” within the meaning of Section 2(a)(11) of the Securities Act in which caseconnection with such sales. In such event, any commissions received bypaid, or any discounts or concessions allowed to, any such agents, dealersbroker-dealer or underwritersagent and aany profit on the resale of the shares of common stock purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Selling Stockholders who are "underwriters" within the meaning of Section 2(a)(11) of the Securities Act will be subject to the applicable prospectus delivery requirements of the Securities Act including Rule 172 thereunder and may be subject to certain statutory liabilities of, including but not limited to, Sections 11, 12 and 17 of the Securities Act and Rule 10b-5 under the Exchange Act.

Except as set forth herein, each Selling Stockholder has informed the Company that it is not a registered broker-dealer and does not have any written or oral agreement or understanding, directly or indirectly, with any person to distribute the Common Stock. Upon the Company being notified in writing by a Selling Stockholder that any material arrangement has been entered into with a broker-dealer for the sale of common stock through a block trade, special offering, exchange distribution or secondary distribution or a purchase by a broker or dealer, a supplement to this prospectus will be filed, if required, pursuant to Rule 424(b) under the Securities Act, disclosing (i) the name of each such Selling Stockholder and of the participating broker-dealer(s), (ii) the number of shares of Common Stock involved, (iii) the price at which such the shares of Common Stock were sold, (iv) the commissions paid or discounts or concessions allowed to such broker-dealer(s), where applicable, (v) that such broker-dealer(s) did not conduct any investigation to verify the information set out or incorporated by reference in this prospectus, and (vi) other facts material to the transaction. In order to comply withno event shall any broker-dealer receive fees, commissions and markups, in the aggregate, in excess of eight percent (8.0%) of any offering.

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Under the securities laws of particularsome states, if applicable, the shares of Common Stock may be sold in such states only through registered or licensed brokers or dealers. In addition, in some states the shares of Common Stock may not be sold unless such shares have been registered or qualified for sale in such state or an exemption from registration or qualification is available and is complied with. Subject to the terms of the Registration Rights Agreement, the Company has no obligation to qualify the resale of any shares in any particular state.

There iscan be no assurance that the selling stockholdersany Selling Stockholder will sell any or all of the shares. 14 19 Pursuantshares of Common Stock registered pursuant to the shelf registration rights agreements between usstatement, of which this prospectus forms a part.

Each Selling Stockholder and Advantage Fund II Ltd., Koch Investment Group Limited, Esquire Trade & Finance Inc.,any other person participating in such distribution will be subject to applicable provisions of the Exchange Act and Celeste Trust Reg., we have agreedthe rules and regulations thereunder, including, without limitation, to the extent applicable, Regulation M of the Exchange Act, which may limit the timing of purchases and sales of any of the shares of Common Stock by the Selling Stockholder and any other participating person. To the extent applicable, Regulation M may also restrict the ability of any person engaged in the distribution of the shares of Common Stock to engage in market-making activities with respect to the shares of Common Stock. All of the foregoing may affect the marketability of the shares of Common Stock and the ability of any person or entity to engage in market-making activities with respect to the shares of Common Stock.

We will pay all expenses incurred inof the registration of the shares of Common Stock pursuant to the registration rights agreement, including, without limitation, Commission filing fees and expenses of initial compliance with state securities or “blue sky” laws;provided,however, that each selling stockholder will pay all underwriting discounts, commissions and any similar expenses it incurs in disposing of the Common Stock, if any, and any related legal expenses incurred by such selling stockholders. However, we are not responsible for selling commissions and discounts, brokerage feesit. We will indemnify the Selling Stockholders against certain liabilities, including some liabilities under the Securities Act, in accordance with the Registration Rights Agreements, or any other expenses incurredthe Selling Stockholders will be entitled to contribution. We may be indemnified by the selling stockholders. We have agreed to indemnify each selling shareholder or their transferees or assigneesSelling Stockholders against certaincivil liabilities, including liabilities under the Securities Act of 1933, orthat may arise from any written information furnished to contribute to payments to which such selling shareholder or its pledgees, donees, transferees or other successors in interest may be required to make in respect thereof. In addition to selling their common stock under this prospectus,us by the selling stockholders may: - transfer their common stock in other ways not involving market makers or established trading markets, including by gift, distribution, or other transfer; or - sell their common stock under Rule 144 of the Securities Act. LEGAL OPINIONS James, Driggs, Walch, Santoro, Kearney, Johnson & Thompson will pass upon the validity of the common stock offered under this prospectus. EXPERTS The consolidated financial statements incorporatedSelling Stockholders specifically for use in this prospectus, by referencein accordance with the related Registration Rights Agreements or we may be entitled to our (annual report on Form 10-KSB) for the fiscal year ended January 1, 2000 have been so incorporated in reliance on the report of PricewaterhouseCoopers LLP, independent accountants, given on the authority of said firm as experts in auditing and accounting. contribution.

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WHERE YOU CAN FIND MORE INFORMATION GOVERNMENT FILINGS:

Available Information

We file annual, quarterly and specialcurrent reports, proxy statements and other information with the Securities and Exchange Commission. You may read and copy any document that we fileof this information at the Commission's Public Reference RoomCommission’s public reference room at 450 Fifth100 F Street, N.W.N.E., Room 1024, Washington, D.C. 20549, and at its regional offices located at 7 World Trade Center, 13th Floor, New York, New York 10048, and at Northwestern Atrium Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661.20549. Please call the Commission at 1-800-SEC-0330(800) SEC-0330 or (202) 942-8090 for morefurther information abouton the Public Reference Rooms. Mostpublic reference room. The Commission also maintains an Internet website that contains reports, proxy statements and other information regarding issuers, including us, who file electronically with the Commission. The address of our filings arethat site iswww.sec.gov.

We also availablemaintain an Internet website atwww.diffusionpharma.com, which can be used to youaccess free of charge, atthrough the Commission's web site at http://www.sec.gov. STOCK MARKET: Our common stockinvestor relations section, our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, current reports on Form 8-K and any amendments to those reports, as soon as reasonably practicable after we electronically file such material with or furnish it to the Commission and all such reports of ours going forward. The information set forth on, or connected to, our website is listedexpressly not incorporated by reference into, and does not constitute a part of, this prospectus.

This prospectus is part of a registration statement on the Nasdaq SmallCap Market and similar information can be inspected and copied at the offices of the National Association of Securities Dealers, Inc., 1735 K Street, N.W., Washington, D.C. 20006. REGISTRATION STATEMENT: WeForm S-3 that we have filed a registration statementwith the Commission under the Securities Act, withfor the Commission with respect toregistration under the common stock offered under this prospectus. This prospectus is a partSecurities Act of the registration statement. However, itsecurities offered hereby. This prospectus does not contain all of the information containedset forth in the registration statement, parts of which are omitted in accordance with the rules and its exhibits. You should referregulations of the Commission. Reference is hereby made to the registration statement and its exhibits forwhich contains further information about uswith respect to our company and our securities. Statements herein concerning the common stock offered under this prospectus. INFORMATION INCORPORATED BY REFERENCE: provisions of documents filed as exhibits to the registration statement are necessarily summaries of such documents, and each such statement is qualified by reference to the copy of the applicable document filed with the Commission.

Incorporation of Documents by Reference

The Commission allows us to "incorporateincorporate by reference" thereference information we file with it, whichinto this prospectus. This means that we can disclose important information to you by referring you to another document we filed with the Commission. We will make those documents. The information incorporateddocuments available to you without charge upon your oral or written request. Requests for those documents should be directed to Investor Relations Department, Diffusion Pharmaceuticals Inc., 2020 Avon Court, Suite 4, Charlottesville, Virginia 22902, Attention: Secretary, telephone: (434) 220-0718. This prospectus incorporates by reference is an important partthe following documents (other than any portion of this prospectus, and informationthe respective filings furnished, rather than filed, under the applicable Commission rules) that we file laterhave filed with the Commission will automatically update and supersedebut have not included or delivered with this information. prospectus:

Our Annual Report on Form 10-K for the fiscal year ended December 31, 2016, as amended, filed with the Commission on March 31, 2017.

Our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2017, filed with the Commission on May 15, 2017.

Our Current Reports on Form 8-K filed on January 9, 2017, January 26, 2017 (to the extent not furnished), March 15, 2017, April 3, 2017, April 11, 2017 and May 26, 2017.

Our Definitive Proxy Statement on Schedule 14A filed on May 12, 2016.

The description of our Common Stock included in our amended registration statements on Form 8-A filed on November 8, 2016 under the Exchange Act, and any amendment or report we may file with the Commission for the purpose of updating such description.

We have filed the following documents with the Commission and they are incorporatedalso incorporate by reference into this prospectus: 15 20 - our Annual Report on Form 10-KSB for the fiscal year ended January 1, 2000; - our Quarterly Report on Form 10-QSB for the fiscal quarter ended April 1, 2000; - our Proxy Statement for the 2000 Annual Meeting of Stockholders, dated June 20, 2000; - our Current Reports on Form 8-K, including Exhibits, filed March 24, 2000, June 22, 2000 and July 20, 2000; - the description of our capital stock contained in our registration statement on Form 10-SB, including all amendments or reports filed forand prospectus any future filings we will make with the purpose of updating the description of our capital stock. Please note that all other documents and reports filedCommission under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act following the date of this prospectus and prior to the termination of the offering of the securities covered by this offering will beprospectus (other than current reports or portions thereof furnished under Item 2.02 or Item 7.01 of Form 8-K).This additional information is a part of this prospectus from the date of filing of those documents.

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Any statements made in this prospectus or in a document incorporated or deemed to be incorporated by reference into this prospectus andwill be deemed to be mademodified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus or in any other subsequently filed document, which is also incorporated or deemed to be incorporated into this prospectus, modifies or supersedes the statement. Any statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of itthis prospectus. The information relating to us contained in this prospectus should be read together with the information in the documents incorporated by reference.

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LEGAL MATTERS 

The validity of the issuance of the Common Stock offered by this prospectus will be passed upon for us by Dechert LLP, New York, New York. Any underwriter or agent will be advised about other issues relating to any offering by its own legal counsel.

EXPERTS 

The consolidated financial statements of Diffusion Pharmaceuticals Inc. as of and for the years ended December 31, 2016 and 2015, have been incorporated by reference herein and in the registration statement in reliance upon the report of KPMG LLP, independent registered public accounting firm, incorporated by reference herein, and upon the authority of said firm as experts in accounting and auditing. The audit report covering the December 31, 2016 consolidated financial statements contains an explanatory paragraph that states that the Company has suffered recurring losses from operations, has limited resources available to fund current research and development activities, and will require substantial additional financing to continue to fund its research and development activities, which raise substantial doubt about its ability to continue as a going concern. The consolidated financial statements do not include any adjustments that might result from the dateoutcome of that uncertainty.

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PART II

Information Not Required in Prospectus

Item 14.Other Expenses of Issuance and Distribution

The following is a statement of the filingexpenses (all of our reports and documents. You may request free copies of these filingswhich are estimated) to be incurred by writing or telephoning us at the following address: Investor Relations Titan Motorcycle Co. of America 2222 West Peoria Avenue Phoenix, Arizona 85029 (602) 861-6977 16 21 PART II. INFORMATION NOT REQUIRED IN PROSPECTUS ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION The following are the estimated expenses in connection with the issuance anda distribution of the securities beingCommon Stock registered allunder this registration statement:

SEC registration fee

 $8,896 

Legal fees and expenses

 35,000 

Accounting fees and expenses

 $7,050 

Printing fees

   *

Miscellaneous

   *

Total

 $50,946

 

*

The estimated expenses are presently indeterminable and will be set forth in the applicable prospectus supplement with respect to any offering of the Common Stock registered hereunder.

Item 15.Indemnification of Directors and Officers

The summary set forth below does not purport to be complete and is subject to and qualified in its entirety by reference to our Certificate of Incorporation and Bylaws, each of which will be paidis incorporated by Titan: Securities and Exchange Commission Registration Fee $ 1,000 Nasdaq Listing Fee $ 7,500 Legal Fees and Expenses $ 75,000 Accounting Fees and Expenses $ 7,000 Transfer Agent Fees and Expenses $ 2,000 Miscellaneous $ 10,000 ----------- TOTAL $ 102,500
ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS Subsection 2reference as an exhibit to the registration statement of Section 78.7502 of Chapter 78which this prospectus is a part, and the applicable provisions of the Nevada Revised Statutes (the "NRS") empowersDelaware General Corporation Law.

We are incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation tomay indemnify any personpersons who wasare, or is a party or isare threatened to be made, a partyparties to any threatened, pending or completed action, or suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of thesuch corporation), by reason of the fact that he is orsuch person was aan officer, director, officer, employee or agent of thesuch corporation, or is or was serving at the request of the corporationsuch person as aan officer, director, officer, employee or agent of another corporation or other enterprise, againstenterprise. The indemnity may include expenses (including attorneys'attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by himsuch person in connection with such action, suit or proceeding, if heprovided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation’s best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement or conviction or upon a plea of nolo contendere or its equivalent does not, of itself, create a presumption that the person did not act in good faith or in a manner which he reasonably believed to be in or not opposed to the best interests of theillegal. A Delaware corporation or that, with respect to any criminal action or proceeding, he had reasonable cause to believe his actions were unlawful. Subsection 2 of Section 78.7502 of the NRS empowers a corporation tomay indemnify any personpersons who wasare, or is a party or isare threatened to be made, a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that such person acted in anywas a director, officer, employee or agent of such corporation, or is or was serving at the capacities set forth above againstrequest of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses including attorneys' fees,(including attorneys’ fees) actually and reasonably incurred by himsuch person in connection with the defense or settlement of such action or suit, ifprovided that such person acted in good faith and in a manner he acted under similar standardsor she reasonably believed to those described above expectbe in or not opposed to the corporation’s best interests except that no indemnification may be made in respect of any claim, issueis permitted without judicial approval if the officer or matter as to which such person shall have beendirector is adjudged to be liable to the corporationcorporation. Where an officer or for amounts paid in settlement todirector is successful on the corporation unless and only to the extent that the court in which such actionmerits or suit was brought determines that, despite the adjudication of liability, such person is fairly and reasonably entitled to indemnity for such expenses as the court deems proper. Section 78.7502 of the NRS further provides that to the extent a director or officer of a corporation has been successfulotherwise in the defense of any action suit or proceeding referred to in subsections (1) and (2)above, the corporation must indemnify him or inher against the 17 22 defense of any claim, issueexpenses which such officer or matter therein, he shall be indemnified against expenses (including attorneys' fees)director has actually and reasonably incurred by him in connection therewith. Section 78.751incurred. Our certificate of the NRS provides that any indemnification provided for by Section 78.7502 of the NRS (by court order or otherwise) shall not be deemed exclusive of any other rights to which the indemnified party may be entitledincorporation and that the scope of indemnification shall continue as to directors, officers, employees or agents who have ceased to hold such positions, and to their heirs, executors and administrators. Section 78.752 empowers the corporation to purchase and maintain insurance on behalf of a director, officer, employee or agent of the corporation against any liability asserted against him or incurred by him in any such capacity or arising out of his status as such whether or not the corporation would have the power to indemnify him against such liabilities under Section 78.7502. Article 4.2 of our Articles of Incorporationbylaws provide that no director or officer of ours shall be personally liable to us or any of our stockholders for damages for breach of their fiduciary duty as a director or officer. This provision, however, does not eliminate or limit the liability of our directors or officers for: X acts or omissions which involve intentional misconduct, fraud or a knowing violation of law, or X the payment of distributions in violation of Nevada Revised Statutes Section 78.300. Article VI of our bylaws provides for the indemnification of our directors and officers employees and agents in a manner substantially identical in scope to thatthe fullest extent permitted under the Delaware General Corporation Law.

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Section 78.7502102(b)(7) of the Nevada Revised Statutes. The BylawsDelaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the expensescorporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of officers and directorsfiduciary duties as a director, except for liability for any:

transaction from which the director derives an improper personal benefit;

act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

unlawful payment of dividends or redemption of shares; or

breach of a director’s duty of loyalty to the corporation or its stockholders.

Our certificate of incorporation includes such a provision. Expenses incurred by any officer or director in defending any civil or criminalsuch action, suit or proceeding in advance of its final disposition shall be paid by us as they are incurred and in advance of the final disposition of the action, suit or proceeding, upon receiptdelivery to us of an undertaking, by or on behalf of thesuch director or officer, to repay the amountall amounts so advanced if it isshall ultimately be determined by a court of competent jurisdiction that hesuch director or officer is not entitled to be indemnified. ITEM 16. EXHIBITS
EXHIBIT NUMBER DESCRIPTION - -------------- ----------- 4.1 Certificate of Designations of the Series C Convertible Preferred Stock (incorporated by reference to Exhibit 4.1 to the Company's Current Report on Form 8-K filed June 22, 2000). 4.2 Warrant issued to Esquire Trade & Finance Inc., dated June 20, 2000 (incorporated by reference to Exhibit 4.2 to the Company's Current Report on Form 8-K filed June 22, 2000. 4.3 Warrant issued to Celeste Trust Reg., dated June 20, 2000 (incorporated by reference to Exhibit 4.3 to the Company's Current Report on Form 8-K filed June 22, 2000). 4.4 Warrant issued to Advantage Fund II Ltd., dated June 20, 2000 4.5 Warrant issued to Koch Investment Group Limited, dated June 20, 2000 4.6 Registration Rights Agreementindemnified by the Company.

As permitted by the Delaware General Corporation Law, we have entered into and intend to enter into indemnification agreements with each of our directors and executive officers. These agreements, among other things, require us to indemnify each director and officer to the fullest extent permitted by law and advance expenses to each indemnitee in connection with Esquire Trade & Finance Inc. and Celeste Trust Reg., dated as of June 20, 2000 (incorporated by reference to Exhibit 4.5 to the Company's Current Report on Form 8-K filed June 22, 2000). 5 Opinion of James, Driggs, Walch, Santoro, Kearney, Johnson & Thompson regarding legality.

18 23 10.1 Securities Purchase Agreement with Esquire Trade & Finance Inc. and Celeste Trust Reg., dated as of June 20, 2000 (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K filed June 22, 2000). 23.1 Consent of PricewaterhouseCoopers LLP 23.2 Consent of James, Driggs, Walch, Santoro, Kearney, Johnson & Thompson (included in Exhibit 5). 24 Power of Attorney (included on signature page of registration statement).
ITEM 17. UNDERTAKINGS The undersigned Registrant hereby undertakes: (1) To file, during any periodproceeding in which offersindemnification is available.

We have an insurance policy covering our officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act or sales are being made, a post-effective amendmentotherwise.

Item 16.  Exhibits

The exhibits to this registration statement to include any material information with respect to the plan of distribution not previously disclosedare listed in the registration statement or any material change toexhibit index that immediately precedes such exhibits and is incorporated herein by reference.

Item 17.  Undertakings

(a)

The undersigned registrant hereby undertakes:

(1)

To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i)

To include any prospectus required by Section 10(a)(3) of the Securities Act;

(ii)

To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and

(iii)

To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

provided, however, that paragraphs (a)(1)(i), (ii) and (iii) do not apply if the information in the registration statement; (2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemedrequired to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof; (3) To remove from registration by means ofincluded in a post-effective amendment any ofby those paragraphs is contained in reports filed with or furnished to the securities being registered which remain unsold atCommission by the termination of the offering. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's Annual Report under Section 13(a)registrant pursuant to section 13 or Sectionsection 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report under Section 15(d) of the Securities Exchange Act of 1934) that isare incorporated by reference in the registration statement, shall be deemedor is contained in a form of prospectus filed pursuant to be a new registration statement relating to the securities offered therein, and the offering of such securities atRule 424(b) that time shall be deemed to be the initial bona fide offering thereof. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling personsis part of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. 19 24 registration statement.

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(2)

That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initialbona fide offering thereof.

(3)

To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(4)

That, for the purpose of determining liability under the Securities Act to any purchaser:

(i)

Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

(ii)

Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initialbona fide offering thereof.Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.

(b)

The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant’s annual report pursuant to section 13(a) or section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initialbona fide offering thereof.

(c)

Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue

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SIGNATURES

Pursuant to the requirements of the Securities Act, of 1933, the Registrantregistrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Amendment No. 1 to the Registration Statement on Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in the Citycity of Phoenix, StateCharlottesville, Commonwealth of Arizona,Virginia, on July 20, 2000. TITAN MOTORCYCLE CO. OF AMERICA /s/ Francis S. Keery Francis S. Keery, Chairmanthis 30th day of the Board of Directors and Chief Executive Officer Know all men by these presents, that each person whose signature appears below constitutes and appoints Francis S. Keery, Robert P. Lobban, Patrick Keery, and Barbara S. Keery, and each of them, his true and lawful attorneys-in-fact and agent, with full powers of substitution and resubstitution, for him and in his name, place, and stead, in any and all capacities, to sign any and all amendments to this registration statement on Form S-3 and to sign any registration statement for the same offering that is to be effective upon filing pursuant to Rule 462(b) of the Securities Act of 1933, and to file the same, with all exhibits thereto, and other documents in connection therewith with the Securities and Exchange Commission, granting under said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises as fully and to all intents and purposes as he might or could do in person hereby ratifying and confirming all that said attorneys-in-fact and agents, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. May, 2017.

DIFFUSION PHARMACEUTICALS INC.

By:

/s/ David G. Kalergis

David G. Kalergis

Chief Executive Officer
(Principal Executive Officer)

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statementAmendment No. 1 to the Registration Statement has been signed below by the following persons in the capacities and on the datedates indicated.

SIGNATURE TITLE DATE --------- ----- ---- /s/ Francis S. Keery

Signature

Title

Date

/s/ David G. Kalergis

Chief Executive Officer and Chairman of the

May 30, 2017

David G. Kalergis

/s/ Ben L. Shealy

Senior Vice President – Finance, Treasurer and

Secretary (Principal Financial Officer)

May 30, 2017

Ben L. Shealy

*

Vice Chairman, Board of Directors and Chief July 20, 2000 - ---------------------------------------- Executive Officer (Principal Executive Officer) Francis S. Keery /s/

May 30, 2017

Isaac Blech

*

Director

May 30, 2017

John L. Gainer, Ph.d.

*

Director

May 30, 2017

Robert P. Lobban Chief Financial Officer (Principal Financial July 20, 2000 - ---------------------------------------- Officer and Principal Accounting Officer) Robert P. Lobban /s/ Patrick Keery President and Adams

*

Director July 20, 2000 - ---------------------------------------- Patrick Keery /s/ Barbara S. Keery Vice President, Secretary and

May 30, 2017

Mark T. Giles

*

Director July 20, 2000 - ---------------------------------------- Barbara S. Keery /s/ Harry H. Birkenruth Director July 20, 2000 - ---------------------------------------- Harry H. Birkenruth /s/ H.B. Tony Turner Director July 20, 2000 - ---------------------------------------- H.B. Tony Turner

May 30, 2017

Alan Levin

20 25 **

*By:

/s/ David G. Kalergis

David G. Kalergis
Attorney-in-fact

-28-

EXHIBIT INDEX TO EXHIBITS

EXHIBIT NUMBER DESCRIPTION - -------------- ----------- 4.1

Exhibit No.

Description

3.1*

Certificate of Incorporation of Diffusion Pharmaceuticals Inc., as amended (incorporated by reference to Exhibit 3.1 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2016 (File No. 001-37942), filed March 31, 2017).

3.2*

Bylaws of Diffusion Pharmaceuticals Inc., as amended (incorporated by reference to Exhibit 3.4 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2015 (File No. 001-24477), filed March 25, 2016).

3.3*

Certificate of Designations of thefor Series CA Convertible Preferred Stock (incorporated by reference to Exhibit 4.13.1 to the Company'sRegistrant’s Current Report on Form 8-K (File No. 001-37942), filed March 15, 2017).

3.4*

Certificate of Conversion, as filed with the Secretary of State of the State of Delaware on June 18, 2015 (incorporated by reference to Exhibit 3.2 to the Registrant’s Current Report on Form 8-K (File No. 001-24477), filed June 22, 2000)18, 2015). 4.2

4.1*

Form of Warrant issued to Esquire Trade & FinanceInvestors in the 2017 Private Placement by Diffusion Pharmaceuticals Inc. (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K (File No. 001-37942), dated June 20, 2000filed March 15, 2017).

4.2*

Form of Registration Rights Agreement entered into by and among the Company and Investors in the 2017 Series A Private Placement (incorporated by reference to Exhibit 4.2 to the Company'sRegistrant’s Quarterly Report on Form 10-Q for the period ended March 31, 2017 (File No. 001-37942), filed May 15, 2017).

4.3*

Form of Diffusion Pharmaceuticals Inc. Convertible Note Agreement (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K (File No. 001-37942), filed June 22, 2000. 4.3 Warrant issued to Celeste Trust Reg., dated June 20, 2000October 3, 2016).

4.4*

Form of Diffusion Pharmaceuticals LLC Convertible Note Agreement (incorporated by reference to Exhibit 4.34.7 to the Company's CurrentRegistrant’s Annual Report on Form 8-K10-K for the year ended December 31, 2015 (File No. 001-24477), filed June 22, 2000)March 25, 2016). 4.4 Warrant issued to Advantage Fund II Ltd., dated June 20, 2000 4.5 Warrant issued to Koch Investment Group Limited, dated June 20, 2000 4.6 Registration Rights Agreement with Advantage Fund II Ltd., dated as of June 20, 2000 (incorporated by reference to Exhibit 4.5 to the Company's Current Report on Form 8-K filed June 22, 2000). 5

5.1*

Opinion of James, Driggs, Walch, Santoro, Kearney, Johnson & ThompsonDechert LLP regarding legality. validity

10.1 Securities Purchase*

Placement Agency Agreement, with Esquire Trade & Financedated January 27, 2017, by and between Diffusion Pharmaceuticals Inc. and Celeste Trust Reg., dated asMaxim Merchant Capital, a division of June 20, 2000Maxim Group LLC (incorporated by reference to Exhibit 10.1 to the Company'sRegistrant’s Current Report on Form 8-K (File No. 001-37942), filed June 22, 2000)March 15, 2017).

10.2*

Form of 2017 Private Placement Subscription Agreement (incorporated by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K (File No. 001-37942), filed March 15, 2017).

10.3*

Amendment to the Placement Agency Agreement, dated March 14, 2017, by and between Diffusion Pharmaceuticals Inc. and Maxim Merchant Capital, a division of Maxim Group LLC (incorporated by reference to Exhibit 10.17 to the Registrant’s Annual Report on Form 10-K for the year ended December 31, 2016 (File No. 001-37942), filed March 31, 2017).

23.1

Consent of PriceWaterhouseCoopersKPMG LLP

23.2*

Consent of James, Driggs, Walch, Santoro, Kearney, Johnson & ThompsonDechert LLP (included in Exhibit 5). 24 Power5.1)

24.1*

Powers of Attorney (included on signature page of registration statement). the Registration Statement)

*    -    Previously filed.