The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 2,502 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 5,550 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 10,296 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
ACCELERON PHARMA INC | COM | 00434H108 | 61,620 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 9,660 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
ADURO BIOTECH INC | COM | 00739L101 | 1,540 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 1,157 | 168,954 | SH | DFND | 1,2,3,4,5,6 | 168,954 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 7,500 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 24,940 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 4,988 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 2,057 | 425,000 | SH | DFND | 1,2,3,4,5,6 | 425,000 | 0 | 0 | |
ALBIREO PHARMA INC | COM | 01345P106 | 14,508 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 10,005 | 850,000 | SH | DFND | 1,2,3,4,5,6 | 850,000 | 0 | 0 | |
ALECTOR INC | COM | 014442107 | 4,275 | 225,000 | SH | DFND | 1,2,3,4,5,6 | 225,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 76,253 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 33,890 | 200,000 | SH | Call | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 |
ALLOGENE THERAPEUTICS INC | COM | 019770106 | 5,370 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 29,024 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 10,884 | 150,000 | SH | Call | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 |
AMERICAN AIRLS GROUP INC | COM | 02376R102 | 16,305 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 31,200 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
ARAVIVE INC | COM | 03890D108 | 1,845 | 307,466 | SH | DFND | 1,2,3,4,5,6 | 307,466 | 0 | 0 | |
ARCUS BIOSCIENCES INC | COM | 03969F109 | 2,147 | 270,000 | SH | DFND | 1,2,3,4,5,6 | 270,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 31,148 | 220,000 | SH | DFND | 1,2,3,4,5,6 | 220,000 | 0 | 0 | |
ARQULE INC | COM | 04269E107 | 7,707 | 700,000 | SH | DFND | 1,2,3,4,5,6 | 700,000 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 17,273 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 23,127 | 1,150,000 | SH | DFND | 1,2,3,4,5,6 | 1,150,000 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 13,251 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPONSORED ADS | 05280R100 | 8,050 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 133,630 | 7,000,000 | SH | DFND | 1,2,3,4,5,6 | 7,000,000 | 0 | 0 | |
AVROBIO INC | COM | 05455M100 | 1,463 | 90,000 | SH | DFND | 1,2,3,4,5,6 | 90,000 | 0 | 0 | |
AXCELLA HEALTH INC | COM | 05454B105 | 3,628 | 389,741 | SH | DFND | 1,2,3,4,5,6 | 389,741 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 80,568 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
BLUEBIRD BIO INC | COM | 09609G100 | 12,720 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 70,748 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 5,394 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 102,038 | 2,250,000 | SH | Call | DFND | 1,2,3,4,5,6 | 2,250,000 | 0 | 0 |
CHANGE HEALTHCARE INC | COM | 15912K100 | 10,950 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 4,710 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
CROWDSTRIKE HLDGS INC | CL A | 22788C105 | 6,829 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 15,590 | 1,361,584 | SH | DFND | 1,2,3,4 | 1,361,584 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 8,304 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
DICERNA PHARMACEUTICALS INC | COM | 253031108 | 15,750 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
EPIZYME INC | COM | 29428V104 | 20,708 | 1,650,000 | SH | DFND | 1,2,3,4,5,6 | 1,650,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 30,450 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 8,132 | 180,000 | SH | DFND | 1,2,3,4,5,6 | 180,000 | 0 | 0 | |
FRONTDOOR INC | COM | 35905A109 | 4,355 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
GENERAL MTRS CO | COM | 37045V100 | 38,530 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 |
GOSSAMER BIO INC | COM | 38341P102 | 8,872 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 26,815 | 1,208,968 | SH | DFND | 1,2,3,4 | 1,208,968 | 0 | 0 | |
GRITSTONE ONCOLOGY INC | COM | 39868T105 | 5,570 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 3,601 | 535,000 | SH | DFND | 1,2,3,4,5,6 | 535,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 4,035 | 599,616 | SH | DFND | 1,2,3,4 | 599,616 | 0 | 0 | |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 12,688 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 21,240 | 250,000 | SH | Call | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 17,164 | 700,000 | SH | DFND | 1,2,3,4,5,6 | 700,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,209 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 4,640 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 5,806 | 500,500 | SH | DFND | 1,2,3,4 | 500,500 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 12,081 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 22,117 | 3,516,214 | SH | DFND | 1,2,3,4,5,6 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 356,798 | 56,724,650 | SH | DFND | 1,2,3,4 | 56,724,650 | 0 | 0 | |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 3,668 | 35,000 | SH | DFND | 1,2,3,4,5,6 | 35,000 | 0 | 0 | |
MAGENTA THERAPEUTICS INC | COM | 55910K108 | 347 | 23,524 | SH | DFND | 1,2,3,4,5,6 | 23,524 | 0 | 0 | |
MEDICINES CO | COM | 584688105 | 36,470 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
MELCO RESORTS AND ENTMT LTD | ADR | 585464100 | 21,720 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 |
MERUS N V | COM | N5749R100 | 5,128 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 15,450 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 7,320 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 67,436 | 4,606,298 | SH | DFND | 1,2,3,4 | 4,606,298 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 9,910 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 24,906 | 700,000 | SH | DFND | 1,2,3,4,5,6 | 700,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 3,558 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 16,886 | 200,000 | SH | Call | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 |
NGM BIOPHARMACEUTICALS INC | COM | 62921N105 | 1,464 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
NIO INC | SPONSORED ADS | 62914V106 | 12,368 | 4,850,000 | SH | DFND | 1,2,3,4,5,6 | 4,850,000 | 0 | 0 | |
NIO INC | SPONSORED ADS | 62914V106 | 4,463 | 1,750,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,750,000 | 0 | 0 |
NVIDIA CORP | COM | 67066G104 | 68,977 | 420,000 | SH | DFND | 1,2,3,4,5,6 | 420,000 | 0 | 0 | |
NVIDIA CORP | COM | 67066G104 | 16,423 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 4,897 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 11,830 | 1,300,000 | SH | DFND | 1,2,3,4,5,6 | 1,300,000 | 0 | 0 | |
THE REALREAL INC | COM | 88339P101 | 578 | 20,000 | SH | DFND | 1,2,3,4,5,6 | 20,000 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 7,449 | 145,000 | SH | DFND | 1,2,3,4,5,6 | 145,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 8,796 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
RESTORBIO INC | COM | 76133L103 | 3,672 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 5,400 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 7,079 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 37,497 | 2,383,791 | SH | DFND | 1,2,3,4 | 2,383,791 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 27,464 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 4,362 | 405,000 | SH | DFND | 1,2,3,4,5,6 | 405,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 6,344 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 30,864 | 1,946,040 | SH | DFND | 1,2,3,4 | 1,946,040 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 3,759 | 2,100,000 | SH | DFND | 1,2,3,4,5,6 | 2,100,000 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM | 83422E105 | 6,900 | 1,200,000 | SH | DFND | 1,2,3,4,5,6 | 1,200,000 | 0 | 0 | |
SPERO THERAPEUTICS INC | COM | 84833T103 | 6,215 | 540,000 | SH | DFND | 1,2,3,4,5,6 | 540,000 | 0 | 0 | |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 5,515 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 8,874 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
TCR2 THERAPEUTICS INC | COM | 87808K106 | 7,012 | 490,000 | SH | DFND | 1,2,3,4,5,6 | 490,000 | 0 | 0 | |
TG THERAPEUTICS INC | COM | 88322Q108 | 7,785 | 900,000 | SH | DFND | 1,2,3,4,5,6 | 900,000 | 0 | 0 | |
TRANSLATE BIO INC | COM | 89374L104 | 9,473 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
TRICIDA INC | COM | 89610F101 | 14,206 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 8,140 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
TWIST BIOSCIENCE CORP | COM | 90184D100 | 2,901 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
UBER TECHNOLOGIES INC | COM | 90353T100 | 23,190 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
VIKING THERAPEUTICS INC | COM | 92686J106 | 830 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 283,030 | 14,818,300 | SH | DFND | 1,2,3,4,7 | 14,818,300 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 11,256 | 275,000 | SH | DFND | 1,2,3,4,5,6 | 275,000 | 0 | 0 | |
Y MABS THERAPEUTICS INC | COM | 984241109 | 9,148 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ZILLOW GROUP INC | CL C CAP STK | 98954M200 | 46,390 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 |