The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 3,166 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 4,950 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 9,285 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
ACCELERON PHARMA INC | COM | 00434H108 | 59,265 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 4,635 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
ADURO BIOTECH INC | COM | 00739L101 | 1,060 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 2,307 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 6,450 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 12,960 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 1,666 | 425,000 | SH | DFND | 1,2,3,4,5,6 | 425,000 | 0 | 0 | |
ALBIREO PHARMA INC | COM | 01345P106 | 9,004 | 450,200 | SH | DFND | 1,2,3,4,5,6 | 450,200 | 0 | 0 | |
ALECTOR INC | COM | 014442107 | 3,245 | 225,000 | SH | DFND | 1,2,3,4,5,6 | 225,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 75,254 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 16,723 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
ALLOGENE THERAPEUTICS INC | COM | 019770106 | 2,726 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 56,294 | 700,000 | SH | DFND | 1,2,3,4,5,6 | 700,000 | 0 | 0 | |
AMERICAN AIRLS GROUP INC | COM | 02376R102 | 13,485 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 20,050 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 4,010 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
ARAVIVE INC | COM | 03890D108 | 3,000 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 22,792 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
ARQULE INC | COM | 04269E107 | 6,095 | 850,000 | SH | DFND | 1,2,3,4,5,6 | 850,000 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 14,448 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 21,180 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 9,832 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPONSORED ADS | 05280R100 | 6,210 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 88,200 | 6,000,000 | SH | DFND | 1,2,3,4,5,6 | 6,000,000 | 0 | 0 | |
AVROBIO INC | COM | 05455M100 | 331 | 23,449 | SH | DFND | 1,2,3,4,5,6 | 23,449 | 0 | 0 | |
AXCELLA HEALTH INC | COM | 05454B105 | 2,547 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
BANK AMER CORP | COM | 060505104 | 87,510 | 3,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 3,000,000 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 79,599 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
BLUEBIRD BIO INC | COM | 09609G100 | 9,182 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 44,082 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 4,294 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 177,485 | 3,500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 3,500,000 | 0 | 0 |
CLOVIS ONCOLOGY INC | COM | 189464100 | 1,965 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 16,502 | 1,361,584 | SH | DFND | 1,2,3,4 | 1,361,584 | 0 | 0 | |
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 16,970 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
DELPHI TECHNOLOGIES PLC | SHS | G2709G107 | 10,050 | 750,000 | SH | Call | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 |
DENALI THERAPEUTICS INC | COM | 24823R105 | 6,128 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
DICERNA PHARMACEUTICALS INC | COM | 253031108 | 14,360 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
DOUYU INTERNATIONAL HLDNGS L | SPONSORED ADS | 25985W105 | 3,276 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
EPIZYME INC | COM | 29428V104 | 15,473 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 31,060 | 2,000,000 | SH | DFND | 1,2,3,4,5,6 | 2,000,000 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 6,656 | 180,000 | SH | DFND | 1,2,3,4,5,6 | 180,000 | 0 | 0 | |
FIDELITY NATL INFORMATION SV | COM | 31620M106 | 9,957 | 75,000 | SH | DFND | 1,2,3,4,5,6 | 75,000 | 0 | 0 | |
GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 16,982 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 6,716 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 20,299 | 1,208,968 | SH | DFND | 1,2,3,4 | 1,208,968 | 0 | 0 | |
GRITSTONE ONCOLOGY INC | COM | 39868T105 | 2,159 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 4,013 | 535,000 | SH | DFND | 1,2,3,4,5,6 | 535,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 4,497 | 599,616 | SH | DFND | 1,2,3,4 | 599,616 | 0 | 0 | |
IGM BIOSCIENCES INC | COM | 449585108 | 3,550 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 18,558 | 250,000 | SH | Call | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 12,740 | 700,000 | SH | DFND | 1,2,3,4,5,6 | 700,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 949 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 3,012 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 3,769 | 500,500 | SH | DFND | 1,2,3,4 | 500,500 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 5,209 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 3,793 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 10,584 | 3,516,214 | SH | DFND | 1,2,3,4,5,6 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 170,741 | 56,724,650 | SH | DFND | 1,2,3,4 | 56,724,650 | 0 | 0 | |
LIONS GATE ENTMNT CORP | CL A VTG | 535919401 | 4,625 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MEDICINES CO | COM | 584688105 | 70,000 | 1,400,000 | SH | DFND | 1,2,3,4,5,6 | 1,400,000 | 0 | 0 | |
MERUS N V | COM | N5749R100 | 8,910 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
MINERVA NEUROSCIENCES INC | COM | 603380106 | 7,750 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 15,582 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 7,960 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 73,332 | 4,606,298 | SH | DFND | 1,2,3,4 | 4,606,298 | 0 | 0 | |
MORGAN STANLEY | COM NEW | 617446448 | 64,005 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 |
MORPHIC HLDG INC | COM | 61775R105 | 9,055 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 23,890 | 1,319,186 | SH | DFND | 1,2,3,4 | 1,319,186 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 9,108 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 10,929 | 600,000 | SH | Call | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 |
NIO INC | SPONSORED ADS | 62914V106 | 3,120 | 2,000,000 | SH | DFND | 1,2,3,4,5,6 | 2,000,000 | 0 | 0 | |
NIO INC | SPONSORED ADS | 62914V106 | 2,730 | 1,750,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,750,000 | 0 | 0 |
NVIDIA CORP | COM | 67066G104 | 34,814 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 4,158 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 7,488 | 1,300,000 | SH | DFND | 1,2,3,4,5,6 | 1,300,000 | 0 | 0 | |
THE REALREAL INC | COM | 88339P101 | 12,633 | 565,000 | SH | DFND | 1,2,3,4,5,6 | 565,000 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 5,162 | 145,000 | SH | DFND | 1,2,3,4,5,6 | 145,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 8,340 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
RESTORBIO INC | COM | 76133L103 | 4,420 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 3,533 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 18,713 | 2,383,791 | SH | DFND | 1,2,3,4 | 2,383,791 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 21,044 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 3,665 | 405,000 | SH | DFND | 1,2,3,4,5,6 | 405,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 3,580 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 17,417 | 1,946,040 | SH | DFND | 1,2,3,4 | 1,946,040 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 3,675 | 2,100,000 | SH | DFND | 1,2,3,4,5,6 | 2,100,000 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM | 83422E105 | 17,578 | 1,700,000 | SH | DFND | 1,2,3,4,5,6 | 1,700,000 | 0 | 0 | |
SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 19,063 | 250,000 | SH | Call | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 |
SPERO THERAPEUTICS INC | COM | 84833T103 | 5,724 | 540,000 | SH | DFND | 1,2,3,4,5,6 | 540,000 | 0 | 0 | |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 6,689 | 308,526 | SH | DFND | 1,2,3,4,5,6 | 308,526 | 0 | 0 | |
SQUARE INC | CL A | 852234103 | 1,859 | 30,000 | SH | DFND | 1,2,3,4,5,6 | 30,000 | 0 | 0 | |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 3,748 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 10,434 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
TCR2 THERAPEUTICS INC | COM | 87808K106 | 7,092 | 471,846 | SH | DFND | 1,2,3,4,5,6 | 471,846 | 0 | 0 | |
TG THERAPEUTICS INC | COM | 88322Q108 | 5,054 | 900,000 | SH | DFND | 1,2,3,4,5,6 | 900,000 | 0 | 0 | |
TRANSLATE BIO INC | COM | 89374L104 | 7,433 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
TRICIDA INC | COM | 89610F101 | 11,113 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 15,040 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
TWIST BIOSCIENCE CORP | COM | 90184D100 | 2,388 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
UBER TECHNOLOGIES INC | COM | 90353T100 | 15,235 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
VIKING THERAPEUTICS INC | COM | 92686J106 | 2,408 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
WW INTL INC | COM | 98262P101 | 560,428 | 14,818,300 | SH | DFND | 1,2,3,4,7 | 14,818,300 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 10,119 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
Y MABS THERAPEUTICS INC | COM | 984241109 | 10,424 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ZILLOW GROUP INC | CL C CAP STK | 98954M200 | 19,383 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 |