The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 4,375 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 8,520 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 10,140 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
ACCELERON PHARMA INC | COM | 00434H108 | 63,624 | 1,200,000 | SH | DFND | 1,2,3,4,5,6 | 1,200,000 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 4,488 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
ADURO BIOTECH INC | COM | 00739L101 | 1,180 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 2,292 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 10,175 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 28,650 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 2,686 | 425,000 | SH | DFND | 1,2,3,4,5,6 | 425,000 | 0 | 0 | |
ALBIREO PHARMA INC | COM | 01345P106 | 11,444 | 450,200 | SH | DFND | 1,2,3,4,5,6 | 450,200 | 0 | 0 | |
ALECTOR INC | COM | 014442107 | 3,877 | 225,000 | SH | DFND | 1,2,3,4,5,6 | 225,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 95,445 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 115,170 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
AMERICAN AIRLS GROUP INC | COM | 02376R102 | 14,340 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 29,220 | 3,000,000 | SH | DFND | 1,2,3,4,5,6 | 3,000,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 4,870 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
ARAVIVE INC | COM | 03890D108 | 18,455 | 1,350,000 | SH | DFND | 1,2,3,4,5,6 | 1,350,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 56,182 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 13,912 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 28,823 | 1,750,000 | SH | DFND | 1,2,3,4,5,6 | 1,750,000 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPONSORED ADS | 05280R100 | 6,600 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 86,213 | 4,750,000 | SH | DFND | 1,2,3,4,5,6 | 4,750,000 | 0 | 0 | |
AXCELLA HEALTH INC | COM | 05454B105 | 1,805 | 450,000 | SH | DFND | 1,2,3,4,5,6 | 450,000 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 106,086 | 640,000 | SH | DFND | 1,2,3,4,5,6 | 640,000 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 8,455 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 75,489 | 2,228,130 | SH | DFND | 1,2,3,4 | 2,228,130 | 0 | 0 | |
BIONTECH SE | SPONSORED ADS | 09075V102 | 13,552 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
BLUEBIRD BIO INC | COM | 09609G100 | 8,775 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 32,044 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 8,011 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 7,010 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
CLOVIS ONCOLOGY INC | COM | 189464100 | 10,425 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
CLOVIS ONCOLOGY INC | COM | 189464100 | 7,819 | 750,000 | SH | Call | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 |
CURIS INC | COM NEW | 231269200 | 2,550 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 3,673 | 1,350,531 | SH | DFND | 1,2,3,4,5,6 | 1,350,531 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 30 | 11,053 | SH | DFND | 1,2,3,4 | 11,053 | 0 | 0 | |
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 15,560 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 6,968 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
DICERNA PHARMACEUTICALS INC | COM | 253031108 | 11,015 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
DOUYU INTERNATIONAL HLDNGS L | SPONSORED ADS | 25985W105 | 3,388 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
EPIZYME INC | COM | 29428V104 | 55,350 | 2,250,000 | SH | DFND | 1,2,3,4,5,6 | 2,250,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 39,140 | 2,000,000 | SH | DFND | 1,2,3,4,5,6 | 2,000,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 3,914 | 200,000 | SH | Call | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 |
FIBROGEN INC | COM | 31572Q808 | 17,156 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 25,148 | 1,608,968 | SH | DFND | 1,2,3,4,5,6 | 1,608,968 | 0 | 0 | |
HARPOON THERAPEUTICS INC | COM | 41358P106 | 12,572 | 850,000 | SH | DFND | 1,2,3,4,5,6 | 850,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 12,291 | 1,004,987 | SH | DFND | 1,2,3,4,5,6 | 1,004,987 | 0 | 0 | |
IGM BIOSCIENCES INC | COM | 449585108 | 5,724 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 6,111 | 630,019 | SH | DFND | 1,2,3,4,5,6 | 630,019 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 8,732 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 2,930 | 199,700 | SH | DFND | 1,2,3,4,5,6 | 199,700 | 0 | 0 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 13,840 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,471 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 2,513 | 500,500 | SH | DFND | 1,2,3,4,5,6 | 500,500 | 0 | 0 | |
KARUNA THERAPEUTICS INC | COM | 48576A100 | 3,767 | 50,000 | SH | DFND | 1,2,3,4,5,6 | 50,000 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 4,430 | 80,000 | SH | DFND | 1,2,3,4,5,6 | 80,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 5,500 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 14,592 | 3,516,214 | SH | DFND | 1,2,3,4,5,6 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 235,407 | 56,724,650 | SH | DFND | 1,2,3,4 | 61,045,868 | 0 | 0 | |
LIONS GATE ENTMNT CORP | CL A VTG | 535919401 | 5,330 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MERUS N V | COM | N5749R100 | 7,040 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
MINERVA NEUROSCIENCES INC | COM | 603380106 | 7,110 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 90,099 | 4,606,298 | SH | DFND | 1,2,3,4,5,6 | 4,606,298 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 9,780 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MORGAN STANLEY | COM NEW | 617446448 | 102,240 | 2,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 2,000,000 | 0 | 0 |
MORPHIC HLDG INC | COM | 61775R105 | 31,217 | 1,819,186 | SH | DFND | 1,2,3,4,5,6 | 1,319,186 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 10,793 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
NIO INC | SPONSORED ADS | 62914V106 | 7,035 | 1,750,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,750,000 | 0 | 0 |
ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 4,813 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
PAYPAL HLDGS INC | COM | 70450Y103 | 21,634 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 12,883 | 1,300,000 | SH | DFND | 1,2,3,4,5,6 | 1,300,000 | 0 | 0 | |
PROTHENA CORP PLC | SHS | G72800108 | 4,749 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
THE REALREAL INC | COM | 88339P101 | 3,770 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
REATA PHARMACEUTICALS INC | CL A | 75615P103 | 10,222 | 50,000 | SH | DFND | 1,2,3,4,5,6 | 50,000 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 5,941 | 145,000 | SH | DFND | 1,2,3,4,5,6 | 145,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 8,610 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 26,921 | 2,833,791 | SH | DFND | 1,2,3,4,5,6 | 2,833,791 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 10,829 | 150,000 | SH | DFND | 1,2,3,4,5,6 | 150,000 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 3,390 | 405,000 | SH | DFND | 1,2,3,4,5,6 | 405,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 33,557 | 2,546,040 | SH | DFND | 1,2,3,4,5,6 | 2,546,040 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 8,124 | 3,413,629 | SH | DFND | 1,2,3,4,5,6 | 3,413,629 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM | 83422E105 | 8,010 | 1,800,000 | SH | DFND | 1,2,3,4,5,6 | 1,800,000 | 0 | 0 | |
SPERO THERAPEUTICS INC | COM | 84833T103 | 4,808 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 13,472 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 3,827 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 15,956 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
TCR2 THERAPEUTICS INC | COM | 87808K106 | 5,712 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
TG THERAPEUTICS INC | COM | 88322Q108 | 7,215 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
TRANSLATE BIO INC | COM | 89374L104 | 5,291 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
TRICIDA INC | COM | 89610F101 | 13,586 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 18,687 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
TWIST BIOSCIENCE CORP | COM | 90184D100 | 2,100 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
UBER TECHNOLOGIES INC | COM | 90353T100 | 14,870 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
VIKING THERAPEUTICS INC | COM | 92686J106 | 2,807 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
WW INTL INC | COM | 98262P101 | 566,207 | 14,818,300 | SH | DFND | 1,2,3,4,7 | 14,818,300 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 18,915 | 550,000 | SH | DFND | 1,2,3,4,5,6 | 550,000 | 0 | 0 | |
Y MABS THERAPEUTICS INC | COM | 984241109 | 12,500 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ZILLOW GROUP INC | CL C CAP STK | 98954M200 | 34,455 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 |