The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 4,297 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
21VIANET GROUP INC | SPONSORED ADS | 90138A103 | 13,860 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 6,910 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 4,998 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
ACCELERON PHARMA INC | COM | 00434H108 | 134,805 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 5,556 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
ADURO BIOTECH INC | COM | 00739L101 | 2,740 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 5,862 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 1,864 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 6,125 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 14,192 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 3,222 | 425,000 | SH | DFND | 1,2,3,4,5,6 | 425,000 | 0 | 0 | |
ALBIREO PHARMA INC | COM | 01345P106 | 9,628 | 588,125 | SH | DFND | 1,2,3,4,5,6 | 588,125 | 0 | 0 | |
ALECTOR INC | COM | 014442107 | 6,033 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 77,792 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 77,792 | 400,000 | SH | Call | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 119,735 | 1,100,000 | SH | DFND | 1,2,3,4,5,6 | 1,100,000 | 0 | 0 | |
AMERICAN AIRLS GROUP INC | COM | 02376R102 | 6,095 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 46,200 | 5,000,000 | SH | DFND | 1,2,3,4,5,6 | 5,000,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 9,240 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 |
APTINYX INC | COM | 03836N103 | 3,600 | 1,666,666 | SH | DFND | 1,2,3,4,5,6 | 1,666,666 | 0 | 0 | |
ARAVIVE INC | COM | 03890D108 | 8,352 | 1,450,000 | SH | DFND | 1,2,3,4,5,6 | 1,450,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 62,572 | 475,000 | SH | DFND | 1,2,3,4,5,6 | 475,000 | 0 | 0 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 17,262 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 11,261 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 21,275 | 2,500,000 | SH | DFND | 1,2,3,4,5,6 | 2,500,000 | 0 | 0 | |
AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 10,883 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPONSORED ADS | 05280R100 | 2,995 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 56,205 | 4,500,000 | SH | DFND | 1,2,3,4,5,6 | 4,500,000 | 0 | 0 | |
AXCELLA HEALTH INC | COM | 05454B105 | 2,052 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
BK OF AMERICA CORP | COM | 060505104 | 42,460 | 2,000,000 | SH | Call | DFND | 1,2,3,4,5,6 | 2,000,000 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 80,022 | 650,000 | SH | DFND | 1,2,3,4,5,6 | 650,000 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 16,900 | 200,000 | SH | Call | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 130,123 | 2,228,130 | SH | DFND | 1,2,3,4 | 2,228,130 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 42,328 | 1,696,517 | SH | DFND | 1,2,3,4,5,6 | 1,696,517 | 0 | 0 | |
BLUEBIRD BIO INC | COM | 09609G100 | 4,596 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 23,392 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 11,696 | 200,000 | SH | Call | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 15,950 | 550,000 | SH | DFND | 1,2,3,4,5,6 | 550,000 | 0 | 0 | |
CLOVIS ONCOLOGY INC | COM | 189464100 | 6,360 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
CLOVIS ONCOLOGY INC | COM | 189464100 | 3,180 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
CURIS INC | COM NEW | 231269200 | 1,056 | 1,500,000 | SH | DFND | 1,2,3,4,5,6 | 1,500,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 4,904 | 1,850,531 | SH | DFND | 1,2,3,4,5,6 | 1,850,531 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 29 | 11,053 | SH | DFND | 1,2,3,4 | 11,053 | 0 | 0 | |
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 32,936 | 800,000 | SH | DFND | 1,2,3,4,5,6 | 800,000 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 8,755 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
EPIZYME INC | COM | 29428V104 | 35,673 | 2,300,000 | SH | DFND | 1,2,3,4,5,6 | 2,300,000 | 0 | 0 | |
EPIZYME INC | COM | 29428V104 | 3,878 | 250,000 | SH | Call | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 46,641 | 2,100,000 | SH | DFND | 1,2,3,4,5,6 | 2,100,000 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 20,850 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 18,361 | 1,808,968 | SH | DFND | 1,2,3,4,5,6 | 1,808,968 | 0 | 0 | |
HARPOON THERAPEUTICS INC | COM | 41358P106 | 13,896 | 1,200,000 | SH | DFND | 1,2,3,4,5,6 | 1,200,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 6,569 | 796,259 | SH | DFND | 1,2,3,4,5,6 | 796,259 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 4,550 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 3,812 | 630,019 | SH | DFND | 1,2,3,4,5,6 | 630,019 | 0 | 0 | |
SELECT SECTOR SPDR TR | SBI INT-INDS | 81369Y704 | 35,406 | 600,000 | SH | Call | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 22,451 | 750,000 | SH | DFND | 1,2,3,4,5,6 | 750,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,115 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KALEIDO BIOSCIENCES INC | COM | 483347100 | 3,078 | 500,500 | SH | DFND | 1,2,3,4,5,6 | 500,500 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 4,324 | 100,000 | SH | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 3,980 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
LEAP THERAPEUTICS INC | COM | 52187K101 | 395 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 6,857 | 3,516,214 | SH | DFND | 1,2,3,4,5,6 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 110,613 | 56,724,650 | SH | DFND | 1,2,3,4 | 61,045,864 | 0 | 0 | |
MASTERCARD INC | CL A | 57636Q104 | 24,156 | 100,000 | SH | Call | DFND | 1,2,3,4,5,6 | 100,000 | 0 | 0 |
MELCO RESORTS AND ENTMNT LTD | ADR | 585464100 | 6,200 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
MERUS N V | COM | N5749R100 | 6,050 | 500,000 | SH | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 | |
MINERVA NEUROSCIENCES INC | COM | 603380106 | 6,020 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 89,850 | 3,000,000 | SH | DFND | 1,2,3,4,5,6 | 3,000,000 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 26,706 | 1,819,186 | SH | DFND | 1,2,3,4,5,6 | 1,819,186 | 0 | 0 | |
ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 3,012 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
PASSAGE BIO INC | COM | 702712100 | 3,938 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
PAYPAL HLDGS INC | COM | 70450Y103 | 42,126 | 440,000 | SH | DFND | 1,2,3,4,5,6 | 440,000 | 0 | 0 | |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 1,426 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
PREVAIL THERAPEUTICS INC | COM | 74140Y101 | 2,438 | 200,000 | SH | DFND | 1,2,3,4,5,6 | 200,000 | 0 | 0 | |
PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 14,845 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 7,137 | 1,300,000 | SH | DFND | 1,2,3,4,5,6 | 1,300,000 | 0 | 0 | |
PROTHENA CORP PLC | SHS | G72800108 | 3,210 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 8,095 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 5,982 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 546 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 17,283 | 3,883,791 | SH | DFND | 1,2,3,4,5,6 | 3,883,791 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 10,052 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 30,833 | 2,546,040 | SH | DFND | 1,2,3,4,5,6 | 2,546,040 | 0 | 0 | |
SCHRODINGER INC | COM | 80810D103 | 38,698 | 897,445 | SH | DFND | 1,2,3,4,5,6 | 897,445 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 8,227 | 3,413,629 | SH | DFND | 1,2,3,4,5,6 | 3,413,629 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM | 83422E105 | 4,302 | 1,800,000 | SH | DFND | 1,2,3,4,5,6 | 1,800,000 | 0 | 0 | |
SPDR SER TR | S&P BIOTECH | 78464A870 | 38,720 | 500,000 | SH | Call | DFND | 1,2,3,4,5,6 | 500,000 | 0 | 0 |
SPERO THERAPEUTICS INC | COM | 84833T103 | 4,654 | 576,000 | SH | DFND | 1,2,3,4,5,6 | 576,000 | 0 | 0 | |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 9,450 | 350,000 | SH | DFND | 1,2,3,4,5,6 | 350,000 | 0 | 0 | |
STOKE THERAPEUTICS INC | COM | 86150R107 | 5,725 | 250,000 | SH | DFND | 1,2,3,4,5,6 | 250,000 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 8,708 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 3,001 | 506,138 | SH | DFND | 1,2,3,4,5,6 | 506,138 | 0 | 0 | |
TCR2 THERAPEUTICS INC | COM | 87808K106 | 3,096 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
TG THERAPEUTICS INC | COM | 88322Q108 | 9,840 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
TRANSLATE BIO INC | COM | 89374L104 | 5,982 | 600,000 | SH | DFND | 1,2,3,4,5,6 | 600,000 | 0 | 0 | |
TRICIDA INC | COM | 89610F101 | 7,920 | 360,000 | SH | DFND | 1,2,3,4,5,6 | 360,000 | 0 | 0 | |
TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 4,040 | 1,000,000 | SH | DFND | 1,2,3,4,5,6 | 1,000,000 | 0 | 0 | |
TRIP COM GROUP LTD | ADS | 89677Q107 | 10,904 | 465,000 | SH | DFND | 1,2,3,4,5,6 | 465,000 | 0 | 0 | |
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 13,398 | 300,000 | SH | DFND | 1,2,3,4,5,6 | 300,000 | 0 | 0 | |
UBER TECHNOLOGIES INC | COM | 90353T100 | 11,168 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 54,568 | 1,150,000 | SH | DFND | 1,2,3,4,5,6 | 1,150,000 | 0 | 0 | |
WW INTL INC | COM | 98262P101 | 250,577 | 14,818,300 | SH | DFND | 1,2,3,4,7 | 14,818,300 | 0 | 0 | |
Y-MABS THERAPEUTICS INC | COM | 984241109 | 10,440 | 400,000 | SH | DFND | 1,2,3,4,5,6 | 400,000 | 0 | 0 | |
ZILLOW GROUP INC | CL C CAP STK | 98954M200 | 32,418 | 900,000 | SH | DFND | 1,2,3,4,5,6 | 900,000 | 0 | 0 |