The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
23ANDME HOLDING CO | CLASS A COM | 90138Q108 | 1,157 | 661,009 | SH | DFND | 1,2,3,4,5 | 661,009 | 0 | 0 | |
ACELYRIN INC | COM | 00445A100 | 38,063 | 1,821,214 | SH | DFND | 1,2,3,4,5 | 1,821,214 | 0 | 0 | |
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 2,132 | 2,255,375 | SH | DFND | 1,2,3,4,5 | 2,255,375 | 0 | 0 | |
ADAGENE INC | ADS | 005329107 | 1,480 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 1,049 | 1,133,775 | SH | DFND | 1,2,3,4,5 | 1,133,775 | 0 | 0 | |
ADVANCED MICRO DEVICES INC | COM | 007903107 | 683 | 6,000 | SH | DFND | 1,2,3,4,5 | 6,000 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 25,010 | 15,631,235 | SH | DFND | 1,2,3,4,5 | 15,631,235 | 0 | 0 | |
ALLOVIR INC | COM | 019818103 | 22,430 | 6,597,167 | SH | DFND | 1,2,3,4,5 | 6,597,167 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 178 | 936 | SH | DFND | 1,2,3,4,5 | 936 | 0 | 0 | |
ALPHABET INC | CAP STK CL A | 02079K305 | 479 | 4,000 | SH | DFND | 1,2,3,4,5 | 4,000 | 0 | 0 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 12,264 | 1,193,030 | SH | DFND | 1,2,3,4,5 | 1,193,030 | 0 | 0 | |
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 3,755 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 1,304 | 10,000 | SH | DFND | 1,2,3,4,5 | 10,000 | 0 | 0 | |
AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 11,560 | 702,291 | SH | DFND | 1,2,3,4,5 | 702,291 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 57,306 | 4,562,567 | SH | DFND | 1,2,3,4,5 | 4,562,567 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 6,280 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 95,661 | 1,050,067 | SH | DFND | 1,2,3,4,5 | 1,050,067 | 0 | 0 | |
ARAVIVE INC | COM | 03890D108 | 5,761 | 4,572,515 | SH | DFND | 1,2,3,4,5 | 4,572,515 | 0 | 0 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 194 | 5,440 | SH | DFND | 1,2,3,4,5 | 5,440 | 0 | 0 | |
AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 9,680 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
AVIDITY BIOSCIENCES INC | COM | 05370A108 | 3,327 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 350 | 10,975 | SH | DFND | 1,2,3,4,5 | 10,975 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 73,548 | 412,496 | SH | DFND | 1,2,3,4,5 | 412,496 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 436 | 5,028 | SH | DFND | 1,2,3,4,5 | 5,028 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 10,335 | 2,046,517 | SH | DFND | 1,2,3,4,5 | 2,046,517 | 0 | 0 | |
CARIBOU BIOSCIENCES INC | COM | 142038108 | 448 | 105,347 | SH | DFND | 1,2,3,4,5 | 105,347 | 0 | 0 | |
CAVA GROUP INC | COM | 148929102 | 1,310,727 | 32,007,990 | SH | DFND | 1,2,3,4 | 32,007,990 | 0 | 0 | |
CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | 52,099 | 1,638,858 | SH | DFND | 1,2,3,4,5 | 1,638,858 | 0 | 0 | |
CITIZENS FINL GROUP INC | COM | 174610105 | 261 | 10,000 | SH | DFND | 1,2,3,4,5 | 10,000 | 0 | 0 | |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 1,145 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
CROWDSTRIKE HLDGS INC | CL A | 22788C105 | 514 | 3,500 | SH | DFND | 1,2,3,4,5 | 3,500 | 0 | 0 | |
CULLINAN ONCOLOGY INC | COM | 230031106 | 2,690 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
CURIS INC | COM NEW | 231269200 | 1,079 | 1,300,000 | SH | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M204 | 570 | 138,403 | SH | DFND | 1,2,3,4,5 | 138,403 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M105 | 2 | 552 | SH | DFND | 1,2,3,4 | 552 | 0 | 0 | |
CYTOKINETICS INC | COM NEW | 23282W605 | 46,191 | 1,416,031 | SH | DFND | 1,2,3,4,5 | 1,416,031 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 11,400 | 47,500 | SH | DFND | 1,2,3,4,5 | 47,500 | 0 | 0 | |
DATADOG INC | CL A COM | 23804L103 | 492 | 5,000 | SH | DFND | 1,2,3,4,5 | 5,000 | 0 | 0 | |
DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 5,970 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 23,694 | 802,899 | SH | DFND | 1,2,3,4,5 | 802,899 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 9,170 | 815,085 | SH | DFND | 1,2,3,4,5 | 815,085 | 0 | 0 | |
ERASCA INC | COM | 29479A108 | 13,030 | 4,721,194 | SH | DFND | 1,2,3,4,5 | 4,721,194 | 0 | 0 | |
FOGHORN THERAPEUTICS INC | COM | 344174107 | 12,114 | 1,720,720 | SH | DFND | 1,2,3,4,5 | 1,720,720 | 0 | 0 | |
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 8,056 | 1,725,000 | SH | DFND | 1,2,3,4,5 | 1,725,000 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 15,478 | 2,814,191 | SH | DFND | 1,2,3,4,5 | 2,814,191 | 0 | 0 | |
GERON CORP | COM | 374163103 | 17,867 | 5,565,889 | SH | DFND | 1,2,3,4,5 | 5,565,889 | 0 | 0 | |
GLYCOMIMETICS INC | COM | 38000Q102 | 14,945 | 8,589,064 | SH | DFND | 1,2,3,4,5 | 8,589,064 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 3,634 | 3,028,171 | SH | DFND | 1,2,3,4,5 | 3,028,171 | 0 | 0 | |
HARPOON THERAPEUTICS INC | COM | 41358P106 | 710 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
HIPPO HLDGS INC | COM NEW | 433539202 | 397 | 24,000 | SH | DFND | 1,2,3,4,5 | 24,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 4,986 | 5,666,410 | SH | DFND | 1,2,3,4,5 | 5,666,410 | 0 | 0 | |
IGM BIOSCIENCES INC | COM | 449585108 | 23,280 | 2,522,244 | SH | DFND | 1,2,3,4,5 | 4,209,744 | 0 | 0 | |
IKENA ONCOLOGY INC | COM | 45175G108 | 12,133 | 1,849,513 | SH | DFND | 1,2,3,4,5 | 1,849,513 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 2,542 | 850,000 | SH | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 | |
IMMUNOGEN INC | COM | 45253H101 | 14,445 | 765,497 | SH | DFND | 1,2,3,4,5 | 765,497 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 11,258 | 276,077 | SH | DFND | 1,2,3,4,5 | 276,077 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,176 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
ITEOS THERAPEUTICS INC | COM | 46565G104 | 5,296 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
KANZHUN LIMITED | SPONSORED ADS | 48553T106 | 3,311 | 220,000 | SH | DFND | 1,2,3,4,5 | 220,000 | 0 | 0 | |
KE HLDGS INC | SPONSORED ADS | 482497104 | 5,198 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
KINETA INC | COM | 49461C102 | 80 | 31,055 | SH | DFND | 1,2,3,4,5 | 31,055 | 0 | 0 | |
KINNATE BIOPHARMA INC | COM | 49705R105 | 379 | 125,000 | SH | DFND | 1,2,3,4,5 | 125,000 | 0 | 0 | |
KRONOS BIO INC | COM | 50107A104 | 2,654 | 1,542,954 | SH | DFND | 1,2,3,4,5 | 1,542,954 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 41,051 | 349,669 | SH | DFND | 1,2,3,4,5 | 349,669 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 21,351 | 2,018,056 | SH | DFND | 1,2,3,4,5 | 2,018,056 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 41,505 | 1,805,346 | SH | DFND | 1,2,3,4,5 | 1,805,346 | 0 | 0 | |
LAVA THERAPEUTICS NV | SHS | N51517105 | 406 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 8,052 | 3,516,214 | SH | DFND | 1,2,3,4,5 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 261,145 | 114,037,070 | SH | DFND | 1,2,3,4 | 114,037,070 | 0 | 0 | |
LUCID GROUP INC | COM | 549498103 | 3,376 | 490,000 | SH | DFND | 1,2,3,4,5 | 490,000 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 9,967 | 3,029,555 | SH | DFND | 1,2,3,4,5 | 3,029,555 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 1,022 | 3,000 | SH | DFND | 1,2,3,4,5 | 3,000 | 0 | 0 | |
MINK THERAPEUTICS INC | COM | 603693102 | 479 | 228,216 | SH | DFND | 1,2,3,4,5 | 228,216 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 74,254 | 2,055,181 | SH | DFND | 1,2,3,4,5 | 2,055,181 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 9,033 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 20,400 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 122,686 | 2,139,995 | SH | DFND | 1,2,3,4,5 | 2,139,995 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 5,733 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
NANOBIOTIX | SPONSORED ADS | 63009J107 | 5,070 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
NATERA INC | COM | 632307104 | 9,732 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
OMEGA THERAPEUTICS INC | COM | 68217N105 | 14,185 | 2,533,045 | SH | DFND | 1,2,3,4,5 | 2,533,045 | 0 | 0 | |
OVID THERAPEUTICS INC | COM | 690469101 | 8,200 | 2,500,000 | SH | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 | |
PLIANT THERAPEUTICS INC | COM | 729139105 | 27 | 1,490 | SH | DFND | 1,2,3,4,5 | 1,490 | 0 | 0 | |
PORTAGE FINTECH ACQUISITN CO | CLASS A ORD SHS | G7185D106 | 3,941 | 380,000 | SH | DFND | 1,2,3,4,5 | 380,000 | 0 | 0 | |
PROCORE TECHNOLOGIES INC | COM | 74275K108 | 293 | 4,500 | SH | DFND | 1,2,3,4,5 | 4,500 | 0 | 0 | |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 13,810 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 15,244 | 1,213,725 | SH | DFND | 1,2,3,4,5 | 1,213,725 | 0 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 7,406 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 11,610 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 64,243 | 2,401,617 | SH | DFND | 1,2,3,4,5 | 2,401,617 | 0 | 0 | |
ROIVANT SCIENCES LTD | SHS | G76279101 | 16,380 | 1,625,000 | SH | DFND | 1,2,3,4,5 | 1,625,000 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 23,510 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
SANA BIOTECHNOLOGY INC | COM | 799566104 | 2,384 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 68,309 | 9,059,507 | SH | DFND | 1,2,3,4,5 | 9,059,507 | 0 | 0 | |
SCHRODINGER INC | COM | 80810D103 | 34,944 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
SEA LTD | SPONSORED ADS | 81141R100 | 20,314 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
SEER INC | COM CL A | 81578P106 | 20,283 | 4,750,000 | SH | DFND | 1,2,3,4,5 | 4,750,000 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 10,233 | 9,136,635 | SH | DFND | 1,2,3,4,5 | 9,136,635 | 0 | 0 | |
SENTI BIOSCIENCES INC | COM | 81726A100 | 35 | 55,555 | SH | DFND | 1,2,3,4,5 | 55,555 | 0 | 0 | |
SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 9,350 | 1,700,000 | SH | DFND | 1,2,3,4,5 | 1,700,000 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM NEW | 83422E204 | 4,764 | 909,219 | SH | DFND | 1,2,3,4,5 | 909,219 | 0 | 0 | |
SPDR SER TR | S&P BIOTECH | 78464A870 | 83,200 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 47,632 | 1,816,620 | SH | DFND | 1,2,3,4,5 | 1,816,620 | 0 | 0 | |
SQZ BIOTECHNOLOGIES CO | COM | 78472W104 | 434 | 1,606,309 | SH | DFND | 1,2,3,4,5 | 1,606,309 | 0 | 0 | |
STERLING CHECK CORP | COM | 85917T109 | 307 | 25,000 | SH | DFND | 1,2,3,4,5 | 25,000 | 0 | 0 | |
STOKE THERAPEUTICS INC | COM | 86150R107 | 2,658 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 | 4,649 | 1,475,744 | SH | DFND | 1,2,3,4,5 | 1,475,744 | 0 | 0 | |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 4,289 | 42,500 | SH | DFND | 1,2,3,4,5 | 42,500 | 0 | 0 | |
TALARIS THERAPEUTICS INC | COM | 87410C104 | 2,779 | 914,262 | SH | DFND | 1,2,3,4,5 | 914,262 | 0 | 0 | |
TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 952 | 1,440,882 | SH | DFND | 1,2,3,4,5 | 1,440,882 | 0 | 0 | |
UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 656 | 2,971 | SH | DFND | 1,2,3,4,5 | 2,971 | 0 | 0 | |
VENTYX BIOSCIENCES INC | COM | 92332V107 | 13,399 | 408,519 | SH | DFND | 1,2,3,4,5 | 408,519 | 0 | 0 | |
VERVE THERAPEUTICS INC | COM | 92539P101 | 5,625 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 17,965 | 1,911,191 | SH | DFND | 1,2,3,4,5 | 1,911,191 | 0 | 0 | |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 12,013 | 504,978 | SH | DFND | 1,2,3,4,5 | 504,978 | 0 | 0 | |
VISA INC | COM CL A | 92826C839 | 1,781 | 7,500 | SH | DFND | 1,2,3,4,5 | 7,500 | 0 | 0 | |
VOR BIOPHARMA INC | COM | 929033108 | 8,306 | 2,688,015 | SH | DFND | 1,2,3,4,5 | 2,688,015 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 10,449 | 2,870,523 | SH | DFND | 1,2,3,4,5 | 2,870,523 | 0 | 0 | |
XILIO THERAPEUTICS INC | COM | 98422T100 | 1,179 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |