The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
23ANDME HOLDING CO | CLASS A COM | 90138Q108 | 604 | 661,009 | SH | DFND | 1,2,3,4,5 | 661,009 | 0 | 0 | |
ACELYRIN INC | COM | 00445A100 | 22,648 | 3,035,888 | SH | DFND | 1,2,3,4,5 | 3,035,888 | 0 | 0 | |
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 2,005 | 2,255,375 | SH | DFND | 1,2,3,4,5 | 2,255,375 | 0 | 0 | |
ADAGENE INC | ADS | 005329107 | 1,931 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
ADVANCED MICRO DEVICES INC | COM | 007903107 | 369 | 2,500 | SH | DFND | 1,2,3,4,5 | 2,500 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 12,941 | 15,631,235 | SH | DFND | 1,2,3,4,5 | 15,631,235 | 0 | 0 | |
ALLOVIR INC | COM | 019818103 | 4,485 | 6,597,167 | SH | DFND | 1,2,3,4,5 | 6,597,167 | 0 | 0 | |
ALPHABET INC | CAP STK CL A | 02079K305 | 1,090 | 7,800 | SH | DFND | 1,2,3,4,5 | 7,800 | 0 | 0 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 967 | 50,759 | SH | DFND | 1,2,3,4,5 | 50,759 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 1,823 | 12,000 | SH | DFND | 1,2,3,4,5 | 12,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 28,754 | 2,026,364 | SH | DFND | 1,2,3,4,5 | 2,026,364 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 35,475 | 2,500,000 | SH | Call | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 85,082 | 1,421,346 | SH | DFND | 1,2,3,4,5 | 1,421,346 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 44,277 | 116,388 | SH | DFND | 1,2,3,4,5 | 116,388 | 0 | 0 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 31,465 | 1,028,255 | SH | DFND | 1,2,3,4,5 | 1,028,255 | 0 | 0 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 6,120 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 72,952 | 404,480 | SH | DFND | 1,2,3,4,5 | 404,480 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 5,751 | 2,046,517 | SH | DFND | 1,2,3,4,5 | 2,046,517 | 0 | 0 | |
CARIBOU BIOSCIENCES INC | COM | 142038108 | 604 | 105,347 | SH | DFND | 1,2,3,4,5 | 105,347 | 0 | 0 | |
CARTESIAN THERAPEUTICS INC | COM | 816212104 | 6,299 | 9,136,635 | SH | DFND | 1,2,3,4,5 | 9,136,635 | 0 | 0 | |
CAVA GROUP INC | COM | 148929102 | 1,375,703 | 32,007,990 | SH | DFND | 1,2,3,4 | 32,007,990 | 0 | 0 | |
CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 8,060 | 1,012,500 | SH | DFND | 1,2,3,4,5 | 1,012,500 | 0 | 0 | |
CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | 214 | 5,041 | SH | DFND | 1,2,3,4,5 | 5,041 | 0 | 0 | |
CLEARWATER ANALYTICS HLDGS I | CL A | 185123106 | 401 | 20,000 | SH | DFND | 1,2,3,4,5 | 20,000 | 0 | 0 | |
CONFLUENT INC | CLASS A COM | 20717M103 | 445 | 19,000 | SH | DFND | 1,2,3,4,5 | 19,000 | 0 | 0 | |
CURIS INC | COM | 231269309 | 1,339 | 105,000 | SH | DFND | 1,2,3,4,5 | 105,000 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M204 | 464 | 138,403 | SH | DFND | 1,2,3,4,5 | 138,403 | 0 | 0 | |
CYCLERION THERAPEUTICS INC | COM | 23255M204 | 2 | 552 | SH | DFND | 1,2,3,4 | 552 | 0 | 0 | |
CYMABAY THERAPEUTICS INC | COM | 23257D103 | 7,171 | 303,600 | SH | DFND | 1,2,3,4,5 | 303,600 | 0 | 0 | |
CYTOKINETICS INC | COM NEW | 23282W605 | 101,381 | 1,214,284 | SH | DFND | 1,2,3,4,5 | 1,214,284 | 0 | 0 | |
DATADOG INC | CL A COM | 23804L103 | 910 | 7,500 | SH | DFND | 1,2,3,4,5 | 7,500 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 17,230 | 802,899 | SH | DFND | 1,2,3,4,5 | 802,899 | 0 | 0 | |
DLOCAL LTD | CLASS A COM | G29018101 | 354 | 20,000 | SH | DFND | 1,2,3,4,5 | 20,000 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 16,199 | 1,217,960 | SH | DFND | 1,2,3,4,5 | 1,217,960 | 0 | 0 | |
ELI LILLY & CO | COM | 532457108 | 583 | 1,000 | SH | DFND | 1,2,3,4,5 | 1,000 | 0 | 0 | |
ERASCA INC | COM | 29479A108 | 10,056 | 4,721,194 | SH | DFND | 1,2,3,4,5 | 4,721,194 | 0 | 0 | |
FOGHORN THERAPEUTICS INC | COM | 344174107 | 4,649 | 720,720 | SH | DFND | 1,2,3,4,5 | 720,720 | 0 | 0 | |
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 9,663 | 1,005,500 | SH | DFND | 1,2,3,4,5 | 1,005,500 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 4,643 | 2,814,191 | SH | DFND | 1,2,3,4,5 | 2,814,191 | 0 | 0 | |
GLYCOMIMETICS INC | COM | 38000Q102 | 20,270 | 8,589,064 | SH | DFND | 1,2,3,4,5 | 8,589,064 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 11,004 | 12,058,968 | SH | DFND | 1,2,3,4,5 | 12,058,968 | 0 | 0 | |
GOSSAMER BIO INC | COM | 38341P102 | 189 | 207,000 | SH | Call | DFND | 1,2,3,4,5 | 207,000 | 0 | 0 |
HARPOON THERAPEUTICS INC | COM NEW | 41358P205 | 14,828 | 1,304,127 | SH | DFND | 1,2,3,4,5 | 1,304,127 | 0 | 0 | |
HIPPO HLDGS INC | COM NEW | 433539202 | 219 | 24,000 | SH | DFND | 1,2,3,4,5 | 24,000 | 0 | 0 | |
HOOKIPA PHARMA INC | COM | 43906K100 | 4,590 | 5,666,410 | SH | DFND | 1,2,3,4,5 | 5,666,410 | 0 | 0 | |
IGM BIOSCIENCES INC | COM | 449585108 | 25,765 | 3,100,422 | SH | DFND | 1,2,3,4,5 | 4,787,922 | 0 | 0 | |
IKENA ONCOLOGY INC | COM | 45175G108 | 1,969 | 999,513 | SH | DFND | 1,2,3,4,5 | 999,513 | 0 | 0 | |
INTAPP INC | COM | 45827U109 | 665 | 17,500 | SH | DFND | 1,2,3,4,5 | 17,500 | 0 | 0 | |
ITEOS THERAPEUTICS INC | COM | 46565G104 | 4,380 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,264 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KANZHUN LIMITED | SPONSORED ADS | 48553T106 | 1,661 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
KE HLDGS INC | SPONSORED ADS | 482497104 | 4,053 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
KORRO BIO INC | COM | 500946108 | 20,064 | 418,605 | SH | DFND | 1,2,3,4,5 | 418,605 | 0 | 0 | |
KRONOS BIO INC | COM | 50107A104 | 1,054 | 842,954 | SH | DFND | 1,2,3,4,5 | 842,954 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 25,425 | 1,768,056 | SH | DFND | 1,2,3,4,5 | 1,768,056 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 64,433 | 2,530,735 | SH | DFND | 1,2,3,4,5 | 2,530,735 | 0 | 0 | |
LEXEO THERAPEUTICS INC | COM | 52886X107 | 8,098 | 603,435 | SH | DFND | 1,2,3,4,5 | 603,435 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 5,380 | 3,516,214 | SH | DFND | 1,2,3,4,5 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 174,477 | 114,037,070 | SH | DFND | 1,2,3,4 | 114,037,070 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 940 | 2,500 | SH | DFND | 1,2,3,4,5 | 2,500 | 0 | 0 | |
MINK THERAPEUTICS INC | COM | 603693102 | 2 | 1,916 | SH | DFND | 1,2,3,4,5 | 1,916 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 29,375 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
MONGODB INC | CL A | 60937P106 | 409 | 1,000 | SH | DFND | 1,2,3,4,5 | 1,000 | 0 | 0 | |
MORPHIC HLDG INC | COM | 61775R105 | 61,751 | 2,138,188 | SH | DFND | 1,2,3,4,5 | 2,138,188 | 0 | 0 | |
NATERA INC | COM | 632307104 | 12,528 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
NEUMORA THERAPEUTICS INC | COM | 640979100 | 43,524 | 2,552,702 | SH | DFND | 1,2,3,4,5 | 2,552,702 | 0 | 0 | |
OMEGA THERAPEUTICS INC | COM | 68217N105 | 3,984 | 1,323,530 | SH | DFND | 1,2,3,4,5 | 1,323,530 | 0 | 0 | |
OVID THERAPEUTICS INC | COM | 690469101 | 8,050 | 2,500,000 | SH | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 | |
PAYPAL HLDGS INC | COM | 70450Y103 | 307 | 5,000 | SH | DFND | 1,2,3,4,5 | 5,000 | 0 | 0 | |
PAYPAL HLDGS INC | COM | 70450Y103 | 3,562 | 58,000 | SH | Call | DFND | 1,2,3,4,5 | 58,000 | 0 | 0 |
PDD HOLDINGS INC | SPONSORED ADS | 722304102 | 4,755 | 32,500 | SH | DFND | 1,2,3,4,5 | 32,500 | 0 | 0 | |
PEGASYSTEMS INC | COM | 705573103 | 562 | 11,500 | SH | DFND | 1,2,3,4,5 | 11,500 | 0 | 0 | |
PROCORE TECHNOLOGIES INC | COM | 74275K108 | 658 | 9,500 | SH | DFND | 1,2,3,4,5 | 9,500 | 0 | 0 | |
PROTHENA CORP PLC | SHS | G72800108 | 18,219 | 501,360 | SH | DFND | 1,2,3,4,5 | 501,360 | 0 | 0 | |
REMITLY GLOBAL INC | COM | 75960P104 | 486 | 25,000 | SH | DFND | 1,2,3,4,5 | 25,000 | 0 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 5,110 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 4,215 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 48,640 | 1,695,949 | SH | DFND | 1,2,3,4,5 | 1,695,949 | 0 | 0 | |
ROIVANT SCIENCES LTD | SHS | G76279101 | 11,230 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
SAGIMET BIOSCIENCES INC | COM SER A | 786700104 | 5,012 | 924,771 | SH | DFND | 1,2,3,4,5 | 924,771 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 211,677 | 11,259,438 | SH | DFND | 1,2,3,4,5 | 11,259,438 | 0 | 0 | |
SCHRODINGER INC | COM | 80810D103 | 10,740 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
SEA LTD | SPONSORED ADS | 81141R100 | 15,066 | 372,000 | SH | DFND | 1,2,3,4,5 | 372,000 | 0 | 0 | |
SEER INC | COM CL A | 81578P106 | 9,215 | 4,750,000 | SH | DFND | 1,2,3,4,5 | 4,750,000 | 0 | 0 | |
SENTI BIOSCIENCES INC | COM | 81726A100 | 37 | 55,555 | SH | DFND | 1,2,3,4,5 | 55,555 | 0 | 0 | |
SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 52,110 | 3,000,000 | SH | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM NEW | 83422E204 | 5,583 | 909,219 | SH | DFND | 1,2,3,4,5 | 909,219 | 0 | 0 | |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 58,960 | 1,615,348 | SH | DFND | 1,2,3,4,5 | 1,615,348 | 0 | 0 | |
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 3,530 | 86,600 | SH | DFND | 1,2,3,4,5 | 86,600 | 0 | 0 | |
SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 | 19,514 | 2,505,013 | SH | DFND | 1,2,3,4,5 | 2,505,013 | 0 | 0 | |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 7,072 | 67,999 | SH | DFND | 1,2,3,4,5 | 67,999 | 0 | 0 | |
TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 6,484 | 3,663,104 | SH | DFND | 1,2,3,4,5 | 3,663,104 | 0 | 0 | |
TOURMALINE BIO INC | COM | 89157D105 | 2,394 | 91,426 | SH | DFND | 1,2,3,4,5 | 91,426 | 0 | 0 | |
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 6,122 | 1,811,191 | SH | DFND | 1,2,3,4,5 | 1,811,191 | 0 | 0 | |
VISA INC | COM CL A | 92826C839 | 651 | 2,500 | SH | DFND | 1,2,3,4,5 | 2,500 | 0 | 0 | |
VOR BIOPHARMA INC | COM | 929033108 | 5,282 | 2,347,424 | SH | DFND | 1,2,3,4,5 | 2,347,424 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 15,187 | 3,007,400 | SH | DFND | 1,2,3,4,5 | 3,007,400 | 0 | 0 | |
XILIO THERAPEUTICS INC | COM | 98422T100 | 248 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |