The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
89BIO INC | COM | 282559103 | 13,794 | 3,658,869 | SH | SOLE | 3,658,869 | 0 | 0 | ||
9 METERS BIOPHARMA INC | COM | 654405109 | 6,158 | 10,275,887 | SH | SOLE | 10,275,887 | 0 | 0 | ||
ABBVIE INC | COM | 00287Y109 | 148,428 | 915,600 | SH | DFND | 93,200 | 0 | 822,400 | ||
ABCELLERA BIOLOGICS INC | COM | 00288U106 | 40,762 | 4,180,768 | SH | SOLE | 4,180,768 | 0 | 0 | ||
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 4,659 | 1,584,845 | SH | DFND | 178,735 | 0 | 1,406,110 | ||
ACLARIS THERAPEUTICS INC | COM | 00461U105 | 27,237 | 1,579,900 | SH | DFND | 258,400 | 0 | 1,321,500 | ||
ACUTUS MED INC | COM | 005111109 | 3,681 | 2,648,386 | SH | SOLE | 2,648,386 | 0 | 0 | ||
ADAGIO THERAPEUTICS INC | COM | 00534A102 | 23,055 | 5,056,000 | SH | SOLE | 5,056,000 | 0 | 0 | ||
ADICET BIO INC | COM | 007002108 | 148,719 | 7,447,141 | SH | SOLE | 7,447,141 | 0 | 0 | ||
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 6,799 | 2,956,124 | SH | SOLE | 2,956,124 | 0 | 0 | ||
AEROVATE THERAPEUTICS INC | COM | 008064107 | 9,347 | 509,949 | SH | DFND | 107,114 | 0 | 402,835 | ||
ALBIREO PHARMA INC | COM | 01345P106 | 5,787 | 194,000 | SH | SOLE | 194,000 | 0 | 0 | ||
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 36,612 | 4,081,592 | SH | SOLE | 4,081,592 | 0 | 0 | ||
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 10,507 | 621,700 | SH | DFND | 178,700 | 0 | 443,000 | ||
AMGEN INC | COM | 031162100 | 13,808 | 57,100 | SH | SOLE | 0 | 0 | 57,100 | ||
APTINYX INC | COM | 03836N103 | 1,222 | 538,500 | SH | SOLE | 538,500 | 0 | 0 | ||
ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 116,982 | 6,073,850 | SH | DFND | 4,267,564 | 0 | 1,806,286 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 53,540 | 169,800 | SH | SOLE | 0 | 0 | 169,800 | ||
ASLAN PHARMACEUTICALS LTD | ADS | 04522R101 | 1,747 | 1,941,219 | SH | SOLE | 0 | 0 | 1,941,219 | ||
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 10,068 | 1,454,800 | SH | SOLE | 1,454,800 | 0 | 0 | ||
BIOGEN INC | COM | 09062X103 | 24,830 | 117,900 | SH | DFND | 13,300 | 0 | 104,600 | ||
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 85,256 | 719,034 | SH | SOLE | 719,034 | 0 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 126,986 | 1,647,030 | SH | DFND | 125,350 | 0 | 1,521,680 | ||
BIOMX INC | COM | 09090D103 | 5,430 | 2,813,489 | SH | SOLE | 2,813,489 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 203,712 | 4,599,500 | SH | DFND | 480,000 | 0 | 4,119,500 | ||
BRIDGEBIO PHARMA INC | NOTE 2.250% 2/0 | 10806XAD4 | 14,416 | 30,000,000 | PRN | SOLE | 30,000,000 | 0 | 0 | ||
BRIDGEBIO PHARMA INC | NOTE 2.500% 3/1 | 10806XAB8 | 12,000 | 20,000,000 | PRN | SOLE | 20,000,000 | 0 | 0 | ||
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 190,440 | 2,607,700 | SH | DFND | 186,000 | 0 | 2,421,700 | ||
BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 13,493 | 1,452,402 | SH | DFND | 125,678 | 0 | 1,326,724 | ||
CABALETTA BIO INC | COM | 12674W109 | 1,172 | 577,509 | SH | DFND | 275,000 | 0 | 302,509 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 13,832 | 406,100 | SH | DFND | 49,600 | 0 | 356,500 | ||
CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 12,375 | 2,578,174 | SH | SOLE | 2,578,174 | 0 | 0 | ||
CHINOOK THERAPEUTICS INC | COM | 16961L106 | 23,203 | 1,418,300 | SH | DFND | 478,300 | 0 | 940,000 | ||
COMPASS THERAPEUTICS INC | COM | 20454B104 | 29,651 | 21,642,975 | SH | DFND | 18,071,547 | 0 | 3,571,428 | ||
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 11,388 | 6,943,654 | SH | SOLE | 6,943,654 | 0 | 0 | ||
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 70,171 | 3,196,876 | SH | SOLE | 3,196,876 | 0 | 0 | ||
CULLINAN ONCOLOGY INC | COM | 230031106 | 7,023 | 670,787 | SH | SOLE | 670,787 | 0 | 0 | ||
CYBIN INC | COM | 23256X100 | 8,598 | 10,524,300 | SH | SOLE | 0 | 0 | 10,524,300 | ||
CYTOMX THERAPEUTICS INC | COM | 23284F105 | 5,674 | 2,124,975 | SH | DFND | 544,559 | 0 | 1,580,416 | ||
DANAHER CORPORATION | 5% CONV PFD B | 235851409 | 12,696 | 8,039 | PRN | SOLE | 0 | 0 | 8,039 | ||
DECIBEL THERAPEUTICS INC | COM | 24343R106 | 15,033 | 4,945,192 | SH | DFND | 4,061,774 | 0 | 883,418 | ||
DEXCOM INC | COM | 252131107 | 76,689 | 149,900 | SH | DFND | 9,600 | 0 | 140,300 | ||
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 135,263 | 13,944,680 | SH | DFND | 13,679,055 | 0 | 265,625 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 123,759 | 1,051,300 | SH | DFND | 85,000 | 0 | 966,300 | ||
ERASCA INC | COM | 29479A108 | 14,342 | 1,667,693 | SH | SOLE | 0 | 0 | 1,667,693 | ||
EVOLENT HEALTH INC | CL A | 30050B101 | 45,220 | 1,400,000 | SH | SOLE | 0 | 0 | 1,400,000 | ||
EXSCIENTIA PLC | ADS | 30223G102 | 1,800 | 125,000 | SH | SOLE | 125,000 | 0 | 0 | ||
FIELD TRIP HEALTH LTD | COM | 31656R102 | 762 | 576,930 | SH | SOLE | 0 | 0 | 576,930 | ||
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 25,056 | 3,224,770 | SH | DFND | 2,930,670 | 0 | 294,100 | ||
GALAPAGOS NV | SPON ADR | 36315X101 | 12,914 | 208,225 | SH | DFND | 11,800 | 0 | 196,425 | ||
GALECTO INC | COM | 36322Q107 | 9,000 | 4,090,937 | SH | DFND | 3,803,255 | 0 | 287,682 | ||
GEMINI THERAPEUTICS INC | COM | 36870G105 | 8,098 | 5,826,224 | SH | SOLE | 5,826,224 | 0 | 0 | ||
GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 26,132 | 1,428,732 | SH | DFND | 125,000 | 0 | 1,303,732 | ||
GILEAD SCIENCES INC | COM | 375558103 | 17,098 | 287,600 | SH | SOLE | 0 | 0 | 287,600 | ||
GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 54,613 | 1,576,600 | SH | DFND | 52,700 | 0 | 1,523,900 | ||
GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 1,732 | 50,000 | SH | Call | DFND | 24,000 | 0 | 26,000 | |
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 18,372 | 7,884,870 | SH | DFND | 5,970,672 | 0 | 1,914,198 | ||
GRAPHITE BIO INC | COM | 38870X104 | 7,986 | 1,565,812 | SH | DFND | 430,000 | 0 | 1,135,812 | ||
GRAYBUG VISION INC | COM SHS | 38942Q103 | 5,121 | 4,163,347 | SH | SOLE | 4,163,347 | 0 | 0 | ||
GUARDANT HEALTH INC | COM | 40131M109 | 87,794 | 1,325,400 | SH | DFND | 108,700 | 0 | 1,216,700 | ||
HARPOON THERAPEUTICS INC | COM | 41358P106 | 15,106 | 3,039,508 | SH | DFND | 1,371,608 | 0 | 1,667,900 | ||
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 231,100 | 2,196,555 | SH | DFND | 185,000 | 0 | 2,011,555 | ||
HUMANA INC | COM | 444859102 | 166,104 | 381,700 | SH | DFND | 33,000 | 0 | 348,700 | ||
I MAB | SPONSORED ADS | 44975P103 | 1,805 | 111,120 | SH | DFND | 25,000 | 0 | 86,120 | ||
IKENA ONCOLOGY INC | COM | 45175G108 | 17,897 | 2,933,941 | SH | DFND | 1,936,886 | 0 | 997,055 | ||
IKENA ONCOLOGY INC | NONVOTING | 000000000 | 37,914 | 6,215,466 | SH | DFND | 5,586,311 | 0 | 629,155 | ||
ILLUMINA INC | COM | 452327109 | 15,758 | 45,100 | SH | SOLE | 0 | 0 | 45,100 | ||
IMARA INC | COM | 45249V107 | 8,247 | 4,386,568 | SH | DFND | 4,199,068 | 0 | 187,500 | ||
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 3,830 | 128,100 | SH | SOLE | 128,100 | 0 | 0 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 161,157 | 534,200 | SH | DFND | 36,000 | 0 | 498,200 | ||
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 110,440 | 6,633,006 | SH | DFND | 1,263,700 | 0 | 5,369,306 | ||
JANUX THERAPEUTICS INC | COM | 47103J105 | 40,674 | 2,836,386 | SH | DFND | 2,489,664 | 0 | 346,722 | ||
JOUNCE THERAPEUTICS INC | COM | 481116101 | 19,419 | 2,859,900 | SH | DFND | 659,700 | 0 | 2,200,200 | ||
KEROS THERAPEUTICS INC | COM | 492327101 | 91,327 | 1,679,417 | SH | DFND | 1,268,734 | 0 | 410,683 | ||
KINNATE BIOPHARMA INC | COM | 49705R105 | 45,531 | 4,043,629 | SH | DFND | 3,593,629 | 0 | 450,000 | ||
LANDOS BIOPHARMA INC | COM | 515069102 | 418 | 283,217 | SH | SOLE | 0 | 0 | 283,217 | ||
LOGICBIO THERAPEUTICS INC | COM | 54142F102 | 5,758 | 8,466,783 | SH | DFND | 7,948,265 | 0 | 518,518 | ||
LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 606 | 113,500 | SH | SOLE | 0 | 0 | 113,500 | ||
MAGENTA THERAPEUTICS INC | COM | 55910K108 | 6,528 | 2,250,953 | SH | DFND | 543,000 | 0 | 1,707,953 | ||
MEIRAGTX HLDGS PLC | COM | G59665102 | 45,659 | 3,296,666 | SH | DFND | 133,500 | 0 | 3,163,166 | ||
MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 11,373 | 10,154,810 | SH | DFND | 4,471,023 | 0 | 5,683,787 | ||
MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 7,963 | 7,109,954 | PRN | DFND | 4,739,969 | 0 | 2,369,985 | ||
MERSANA THERAPEUTICS INC | COM | 59045L106 | 19,108 | 4,788,900 | SH | DFND | 1,353,000 | 0 | 3,435,900 | ||
MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 16,588 | 2,583,821 | SH | SOLE | 0 | 0 | 2,583,821 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 134,060 | 1,630,500 | SH | DFND | 220,600 | 0 | 1,409,900 | ||
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 595 | 27,000 | SH | SOLE | 27,000 | 0 | 0 | ||
NANOSTRING TECHNOLOGIES INC | NOTE 2.625% 3/0 | 63009RAD1 | 6,086 | 6,000,000 | PRN | SOLE | 0 | 0 | 6,000,000 | ||
NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 40,219 | 1,157,387 | SH | DFND | 67,400 | 0 | 1,089,987 | ||
NATERA INC | COM | 632307104 | 6,102 | 150,000 | SH | Call | DFND | 72,500 | 0 | 77,500 | |
NATERA INC | COM | 632307104 | 64,900 | 1,595,385 | SH | DFND | 125,000 | 0 | 1,470,385 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 82,080 | 875,515 | SH | DFND | 52,970 | 0 | 822,545 | ||
NEUROPACE INC | COM | 641288105 | 32,941 | 4,012,281 | SH | SOLE | 4,012,281 | 0 | 0 | ||
NEXTCURE INC | COM | 65343E108 | 13,176 | 2,711,013 | SH | SOLE | 2,711,013 | 0 | 0 | ||
ONCOCYTE CORP | COM | 68235C107 | 5,206 | 3,493,800 | SH | DFND | 1,188,800 | 0 | 2,305,000 | ||
ORIC PHARMACEUTICALS INC | COM | 68622P109 | 11,148 | 2,087,568 | SH | SOLE | 2,087,568 | 0 | 0 | ||
OWLET INC | *W EXP 09/14/202 | 69120X115 | 170 | 220,704 | SH | DFND | 82,544 | 0 | 138,160 | ||
PASSAGE BIO INC | COM | 702712100 | 22,729 | 7,331,999 | SH | DFND | 6,316,423 | 0 | 1,015,576 | ||
PFIZER INC | COM | 717081103 | 202,188 | 3,905,500 | SH | DFND | 275,000 | 0 | 3,630,500 | ||
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 142,730 | 6,855,423 | SH | DFND | 6,589,330 | 0 | 266,093 | ||
PRELUDE THERAPEUTICS INC | COM | 74065P101 | 69,274 | 10,039,691 | SH | DFND | 9,250,191 | 0 | 789,500 | ||
PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 | 39,193 | 5,680,186 | SH | DFND | 5,596,886 | 0 | 83,300 | ||
PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 4,245 | 830,641 | SH | DFND | 158,900 | 0 | 671,741 | ||
PULMONX CORP | COM | 745848101 | 10,792 | 435,000 | SH | DFND | 83,600 | 0 | 351,400 | ||
PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 580 | 143,640 | SH | DFND | 49,540 | 0 | 94,100 | ||
RAPT THERAPEUTICS INC | COM | 75382E109 | 7,945 | 361,300 | SH | DFND | 144,300 | 0 | 217,000 | ||
REPARE THERAPEUTICS INC | COM | 760273102 | 47,312 | 3,322,488 | SH | DFND | 3,177,041 | 0 | 145,447 | ||
RXSIGHT INC | COM | 78349D107 | 17,128 | 1,383,500 | SH | DFND | 321,000 | 0 | 1,062,500 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,054 | 39,100 | SH | SOLE | 39,100 | 0 | 0 | ||
SCPHARMACEUTICALS INC | COM | 810648105 | 27,248 | 4,797,148 | SH | SOLE | 4,797,148 | 0 | 0 | ||
SEAGEN INC | COM | 81181C104 | 96,182 | 667,700 | SH | DFND | 66,100 | 0 | 601,600 | ||
SI-BONE INC | COM | 825704109 | 70,947 | 3,139,247 | SH | SOLE | 0 | 0 | 3,139,247 | ||
SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 62,971 | 1,964,770 | SH | DFND | 1,738,066 | 0 | 226,704 | ||
SIGHT SCIENCES INC | COM | 82657M105 | 2,312 | 200,000 | SH | SOLE | 0 | 0 | 200,000 | ||
SIGNIFY HEALTH INC | CL A COM | 82671G100 | 11,266 | 620,700 | SH | SOLE | 0 | 0 | 620,700 | ||
SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 30,681 | 8,740,887 | SH | DFND | 7,788,510 | 0 | 952,377 | ||
SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 14,518 | 2,300,792 | SH | DFND | 985,897 | 0 | 1,314,895 | ||
SONENDO INC | COM | 835431107 | 7,892 | 1,968,180 | SH | SOLE | 1,968,180 | 0 | 0 | ||
SPDR SER TR | S&P BIOTECH | 78464A870 | 10,049 | 111,800 | SH | SOLE | 111,800 | 0 | 0 | ||
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 340,238 | 6,028,307 | SH | SOLE | 6,028,307 | 0 | 0 | ||
STRYKER CORPORATION | COM | 863667101 | 122,206 | 457,100 | SH | DFND | 34,000 | 0 | 423,100 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 37,511 | 2,158,300 | SH | DFND | 387,000 | 0 | 1,771,300 | ||
SYNLOGIC INC | COM | 87166L100 | 14,472 | 6,029,995 | SH | SOLE | 6,029,995 | 0 | 0 | ||
TALARIS THERAPEUTICS INC | COM | 87410C104 | 2,433 | 247,240 | SH | SOLE | 0 | 0 | 247,240 | ||
TELA BIO INC | COM | 872381108 | 35,210 | 3,027,542 | SH | SOLE | 3,027,542 | 0 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 54,009 | 628,300 | SH | DFND | 51,000 | 0 | 577,300 | ||
TERNS PHARMACEUTICALS INC | COM | 880881107 | 11,260 | 3,791,204 | SH | SOLE | 3,791,204 | 0 | 0 | ||
THERAVANCE BIOPHARMA INC | COM | G8807B106 | 31,115 | 3,254,713 | SH | DFND | 34,280 | 0 | 3,220,433 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 71,232 | 120,600 | SH | DFND | 12,200 | 0 | 108,400 | ||
THESEUS PHARMACEUTICALS INC | COM | 88369M101 | 196,490 | 17,041,668 | SH | SOLE | 17,041,668 | 0 | 0 | ||
TRICIDA INC | COM | 89610F101 | 84,509 | 10,280,947 | SH | SOLE | 10,280,947 | 0 | 0 | ||
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 54,209 | 2,018,950 | SH | DFND | 1,656,450 | 0 | 362,500 | ||
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 16,528 | 227,600 | SH | DFND | 60,300 | 0 | 167,300 | ||
UNIQURE NV | SHS | N90064101 | 16,611 | 919,249 | SH | DFND | 94,400 | 0 | 824,849 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 150,033 | 294,200 | SH | DFND | 27,000 | 0 | 267,200 | ||
VAXCYTE INC | COM | 92243G108 | 36,555 | 1,513,659 | SH | DFND | 207,945 | 0 | 1,305,714 | ||
VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 25,108 | 5,330,704 | SH | DFND | 5,037,404 | 0 | 293,300 | ||
VENTYX BIOSCIENCES INC | COM | 92332V107 | 17,496 | 1,289,280 | SH | SOLE | 1,289,280 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 28,417 | 5,694,841 | SH | DFND | 5,028,174 | 0 | 666,667 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 104,440 | 400,200 | SH | DFND | 27,000 | 0 | 373,200 | ||
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 2,891 | 411,191 | SH | SOLE | 411,191 | 0 | 0 | ||
VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 16,008 | 12,909,283 | SH | DFND | 2,390,043 | 0 | 10,519,240 | ||
VOR BIOPHARMA INC | COM | 929033108 | 5,033 | 833,333 | SH | SOLE | 0 | 0 | 833,333 | ||
X4 PHARMACEUTICALS INC | COM | 98420X103 | 2,404 | 1,373,849 | SH | SOLE | 1,373,849 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 20,971 | 686,000 | SH | DFND | 55,000 | 0 | 631,000 | ||
XTANT MED HLDGS INC | COM NEW | 98420P308 | 49,602 | 72,943,918 | SH | SOLE | 72,943,918 | 0 | 0 |