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Orbimed Advisors

Filed: 16 May 22, 4:17pm

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
89BIO INCCOM28255910313,7943,658,869SH SOLE 3,658,86900
9 METERS BIOPHARMA INCCOM6544051096,15810,275,887SH SOLE 10,275,88700
ABBVIE INCCOM00287Y109148,428915,600SH DFND 93,2000822,400
ABCELLERA BIOLOGICS INCCOM00288U10640,7624,180,768SH SOLE 4,180,76800
ACHILLES THERAPEUTICS PLCSPONSORED ADS00449L1024,6591,584,845SH DFND 178,73501,406,110
ACLARIS THERAPEUTICS INCCOM00461U10527,2371,579,900SH DFND 258,40001,321,500
ACUTUS MED INCCOM0051111093,6812,648,386SH SOLE 2,648,38600
ADAGIO THERAPEUTICS INCCOM00534A10223,0555,056,000SH SOLE 5,056,00000
ADICET BIO INCCOM007002108148,7197,447,141SH SOLE 7,447,14100
AEGLEA BIOTHERAPEUTICS INCCOM00773J1036,7992,956,124SH SOLE 2,956,12400
AEROVATE THERAPEUTICS INCCOM0080641079,347509,949SH DFND 107,1140402,835
ALBIREO PHARMA INCCOM01345P1065,787194,000SH SOLE 194,00000
ALPINE IMMUNE SCIENCES INCCOM02083G10036,6124,081,592SH SOLE 4,081,59200
ALX ONCOLOGY HLDGS INCCOM00166B10510,507621,700SH DFND 178,7000443,000
AMGEN INCCOM03116210013,80857,100SH SOLE 0057,100
APTINYX INCCOM03836N1031,222538,500SH SOLE 538,50000
ARCUTIS BIOTHERAPEUTICS INCCOM03969K108116,9826,073,850SH DFND 4,267,56401,806,286
ARGENX SESPONSORED ADR04016X10153,540169,800SH SOLE 00169,800
ASLAN PHARMACEUTICALS LTDADS04522R1011,7471,941,219SH SOLE 001,941,219
BELLUS HEALTH INC NEWCOM NEW07987C20410,0681,454,800SH SOLE 1,454,80000
BIOGEN INCCOM09062X10324,830117,900SH DFND 13,3000104,600
BIOHAVEN PHARMACTL HLDG CO LCOMG1119610585,256719,034SH SOLE 719,03400
BIOMARIN PHARMACEUTICAL INCCOM09061G101126,9861,647,030SH DFND 125,35001,521,680
BIOMX INCCOM09090D1035,4302,813,489SH SOLE 2,813,48900
BOSTON SCIENTIFIC CORPCOM101137107203,7124,599,500SH DFND 480,00004,119,500
BRIDGEBIO PHARMA INCNOTE 2.250% 2/010806XAD414,41630,000,000PRN SOLE 30,000,00000
BRIDGEBIO PHARMA INCNOTE 2.500% 3/110806XAB812,00020,000,000PRN SOLE 20,000,00000
BRISTOL-MYERS SQUIBB COCOM110122108190,4402,607,700SH DFND 186,00002,421,700
BURNING ROCK BIOTECH LTDSPONSORED ADS12233L10713,4931,452,402SH DFND 125,67801,326,724
CABALETTA BIO INCCOM12674W1091,172577,509SH DFND 275,0000302,509
CELLDEX THERAPEUTICS INC NEWCOM NEW15117B20213,832406,100SH DFND 49,6000356,500
CHEMOMAB THERAPEUTICS LTDSPONSORED ADS16385C10412,3752,578,174SH SOLE 2,578,17400
CHINOOK THERAPEUTICS INCCOM16961L10623,2031,418,300SH DFND 478,3000940,000
COMPASS THERAPEUTICS INCCOM20454B10429,65121,642,975SH DFND 18,071,54703,571,428
CORVUS PHARMACEUTICALS INCCOM22101510011,3886,943,654SH SOLE 6,943,65400
CRINETICS PHARMACEUTICALS INCOM22663K10770,1713,196,876SH SOLE 3,196,87600
CULLINAN ONCOLOGY INCCOM2300311067,023670,787SH SOLE 670,78700
CYBIN INCCOM23256X1008,59810,524,300SH SOLE 0010,524,300
CYTOMX THERAPEUTICS INCCOM23284F1055,6742,124,975SH DFND 544,55901,580,416
DANAHER CORPORATION5% CONV PFD B23585140912,6968,039PRN SOLE 008,039
DECIBEL THERAPEUTICS INCCOM24343R10615,0334,945,192SH DFND 4,061,7740883,418
DEXCOM INCCOM25213110776,689149,900SH DFND 9,6000140,300
EDGEWISE THERAPEUTICS INCCOM28036F105135,26313,944,680SH DFND 13,679,0550265,625
EDWARDS LIFESCIENCES CORPCOM28176E108123,7591,051,300SH DFND 85,0000966,300
ERASCA INCCOM29479A10814,3421,667,693SH SOLE 001,667,693
EVOLENT HEALTH INCCL A30050B10145,2201,400,000SH SOLE 001,400,000
EXSCIENTIA PLCADS30223G1021,800125,000SH SOLE 125,00000
FIELD TRIP HEALTH LTDCOM31656R102762576,930SH SOLE 00576,930
FUSION PHARMACEUTICALS INCCOM36118A10025,0563,224,770SH DFND 2,930,6700294,100
GALAPAGOS NVSPON ADR36315X10112,914208,225SH DFND 11,8000196,425
GALECTO INCCOM36322Q1079,0004,090,937SH DFND 3,803,2550287,682
GEMINI THERAPEUTICS INCCOM36870G1058,0985,826,224SH SOLE 5,826,22400
GH RESEARCH PLCORDINARY SHARESG3855L10626,1321,428,732SH DFND 125,00001,303,732
GILEAD SCIENCES INCCOM37555810317,098287,600SH SOLE 00287,600
GLOBAL BLOOD THERAPEUTICS INCOM37890U10854,6131,576,600SH DFND 52,70001,523,900
GLOBAL BLOOD THERAPEUTICS INCOM37890U1081,73250,000SHCallDFND 24,000026,000
GRACELL BIOTECHNOLOGIES INCSPONSORED ADS38406L10318,3727,884,870SH DFND 5,970,67201,914,198
GRAPHITE BIO INCCOM38870X1047,9861,565,812SH DFND 430,00001,135,812
GRAYBUG VISION INCCOM SHS38942Q1035,1214,163,347SH SOLE 4,163,34700
GUARDANT HEALTH INCCOM40131M10987,7941,325,400SH DFND 108,70001,216,700
HARPOON THERAPEUTICS INCCOM41358P10615,1063,039,508SH DFND 1,371,60801,667,900
HORIZON THERAPEUTICS PUB LSHSG46188101231,1002,196,555SH DFND 185,00002,011,555
HUMANA INCCOM444859102166,104381,700SH DFND 33,0000348,700
I MABSPONSORED ADS44975P1031,805111,120SH DFND 25,000086,120
IKENA ONCOLOGY INCCOM45175G10817,8972,933,941SH DFND 1,936,8860997,055
IKENA ONCOLOGY INCNONVOTING00000000037,9146,215,466SH DFND 5,586,3110629,155
ILLUMINA INCCOM45232710915,75845,100SH SOLE 0045,100
IMARA INCCOM45249V1078,2474,386,568SH DFND 4,199,0680187,500
IMMUNOCORE HLDGS PLCADS45258D1053,830128,100SH SOLE 128,10000
INTUITIVE SURGICAL INCCOM NEW46120E602161,157534,200SH DFND 36,0000498,200
IOVANCE BIOTHERAPEUTICS INCCOM462260100110,4406,633,006SH DFND 1,263,70005,369,306
JANUX THERAPEUTICS INCCOM47103J10540,6742,836,386SH DFND 2,489,6640346,722
JOUNCE THERAPEUTICS INCCOM48111610119,4192,859,900SH DFND 659,70002,200,200
KEROS THERAPEUTICS INCCOM49232710191,3271,679,417SH DFND 1,268,7340410,683
KINNATE BIOPHARMA INCCOM49705R10545,5314,043,629SH DFND 3,593,6290450,000
LANDOS BIOPHARMA INCCOM515069102418283,217SH SOLE 00283,217
LOGICBIO THERAPEUTICS INCCOM54142F1025,7588,466,783SH DFND 7,948,2650518,518
LONGBOARD PHARMACEUTICALS INCOM54300N103606113,500SH SOLE 00113,500
MAGENTA THERAPEUTICS INCCOM55910K1086,5282,250,953SH DFND 543,00001,707,953
MEIRAGTX HLDGS PLCCOMG5966510245,6593,296,666SH DFND 133,50003,163,166
MEREO BIOPHARMA GROUP PLCADS58949210711,37310,154,810SH DFND 4,471,02305,683,787
MEREO BIOPHARMA GROUP PLCADS5894921077,9637,109,954PRN DFND 4,739,96902,369,985
MERSANA THERAPEUTICS INCCOM59045L10619,1084,788,900SH DFND 1,353,00003,435,900
MILESTONE PHARMACEUTICALS INCOM59935V10716,5882,583,821SH SOLE 002,583,821
MIRATI THERAPEUTICS INCCOM60468T105134,0601,630,500SH DFND 220,60001,409,900
MIRUM PHARMACEUTICALS INCCOM60474910159527,000SH SOLE 27,00000
NANOSTRING TECHNOLOGIES INCNOTE 2.625% 3/063009RAD16,0866,000,000PRN SOLE 006,000,000
NANOSTRING TECHNOLOGIES INCCOM63009R10940,2191,157,387SH DFND 67,40001,089,987
NATERA INCCOM6323071046,102150,000SHCallDFND 72,500077,500
NATERA INCCOM63230710464,9001,595,385SH DFND 125,00001,470,385
NEUROCRINE BIOSCIENCES INCCOM64125C10982,080875,515SH DFND 52,9700822,545
NEUROPACE INCCOM64128810532,9414,012,281SH SOLE 4,012,28100
NEXTCURE INCCOM65343E10813,1762,711,013SH SOLE 2,711,01300
ONCOCYTE CORPCOM68235C1075,2063,493,800SH DFND 1,188,80002,305,000
ORIC PHARMACEUTICALS INCCOM68622P10911,1482,087,568SH SOLE 2,087,56800
OWLET INC*W EXP 09/14/20269120X115170220,704SH DFND 82,5440138,160
PASSAGE BIO INCCOM70271210022,7297,331,999SH DFND 6,316,42301,015,576
PFIZER INCCOM717081103202,1883,905,500SH DFND 275,00003,630,500
PMV PHARMACEUTICALS INCCOM69353Y103142,7306,855,423SH DFND 6,589,3300266,093
PRELUDE THERAPEUTICS INCCOM74065P10169,27410,039,691SH DFND 9,250,1910789,500
PRELUDE THERAPEUTICS INCNONVOTING00000000039,1935,680,186SH DFND 5,596,886083,300
PROTARA THERAPEUTICS INCCOM STK74365U1074,245830,641SH DFND 158,9000671,741
PULMONX CORPCOM74584810110,792435,000SH DFND 83,6000351,400
PYXIS ONCOLOGY INCCOMMON STOCK747324101580143,640SH DFND 49,540094,100
RAPT THERAPEUTICS INCCOM75382E1097,945361,300SH DFND 144,3000217,000
REPARE THERAPEUTICS INCCOM76027310247,3123,322,488SH DFND 3,177,0410145,447
RXSIGHT INCCOM78349D10717,1281,383,500SH DFND 321,00001,062,500
SAREPTA THERAPEUTICS INCCOM8036071003,05439,100SH SOLE 39,10000
SCPHARMACEUTICALS INCCOM81064810527,2484,797,148SH SOLE 4,797,14800
SEAGEN INCCOM81181C10496,182667,700SH DFND 66,1000601,600
SI-BONE INCCOM82570410970,9473,139,247SH SOLE 003,139,247
SIERRA ONCOLOGY INCCOM NEW82640U40462,9711,964,770SH DFND 1,738,0660226,704
SIGHT SCIENCES INCCOM82657M1052,312200,000SH SOLE 00200,000
SIGNIFY HEALTH INCCL A COM82671G10011,266620,700SH SOLE 00620,700
SILVERBACK THERAPEUTICS INCCOM82835W10830,6818,740,887SH DFND 7,788,5100952,377
SINGULAR GENOMICS SYSTEMS INCOM82933R10014,5182,300,792SH DFND 985,89701,314,895
SONENDO INCCOM8354311077,8921,968,180SH SOLE 1,968,18000
SPDR SER TRS&P BIOTECH78464A87010,049111,800SH SOLE 111,80000
SPRINGWORKS THERAPEUTICS INCCOM85205L107340,2386,028,307SH SOLE 6,028,30700
STRYKER CORPORATIONCOM863667101122,206457,100SH DFND 34,0000423,100
SYNDAX PHARMACEUTICALS INCCOM87164F10537,5112,158,300SH DFND 387,00001,771,300
SYNLOGIC INCCOM87166L10014,4726,029,995SH SOLE 6,029,99500
TALARIS THERAPEUTICS INCCOM87410C1042,433247,240SH SOLE 00247,240
TELA BIO INCCOM87238110835,2103,027,542SH SOLE 3,027,54200
TENET HEALTHCARE CORPCOM NEW88033G40754,009628,300SH DFND 51,0000577,300
TERNS PHARMACEUTICALS INCCOM88088110711,2603,791,204SH SOLE 3,791,20400
THERAVANCE BIOPHARMA INCCOMG8807B10631,1153,254,713SH DFND 34,28003,220,433
THERMO FISHER SCIENTIFIC INCCOM88355610271,232120,600SH DFND 12,2000108,400
THESEUS PHARMACEUTICALS INCCOM88369M101196,49017,041,668SH SOLE 17,041,66800
TRICIDA INCCOM89610F10184,50910,280,947SH SOLE 10,280,94700
TURNING POINT THERAPEUTICS ICOM90041T10854,2092,018,950SH DFND 1,656,4500362,500
ULTRAGENYX PHARMACEUTICAL INCOM90400D10816,528227,600SH DFND 60,3000167,300
UNIQURE NVSHSN9006410116,611919,249SH DFND 94,4000824,849
UNITEDHEALTH GROUP INCCOM91324P102150,033294,200SH DFND 27,0000267,200
VAXCYTE INCCOM92243G10836,5551,513,659SH DFND 207,94501,305,714
VECTIVBIO HLDG AGORD SHSH9060V10125,1085,330,704SH DFND 5,037,4040293,300
VENTYX BIOSCIENCES INCCOM92332V10717,4961,289,280SH SOLE 1,289,28000
VERONA PHARMA PLCSPONSORED ADS92505010628,4175,694,841SH DFND 5,028,1740666,667
VERTEX PHARMACEUTICALS INCCOM92532F100104,440400,200SH DFND 27,0000373,200
VIGIL NEUROSCIENCE INCCOM92673K1082,891411,191SH SOLE 411,19100
VISTAGEN THERAPEUTICS INCCOM NEW92840H20216,00812,909,283SH DFND 2,390,043010,519,240
VOR BIOPHARMA INCCOM9290331085,033833,333SH SOLE 00833,333
X4 PHARMACEUTICALS INCCOM98420X1032,4041,373,849SH SOLE 1,373,84900
XENON PHARMACEUTICALS INCCOM98420N10520,971686,000SH DFND 55,0000631,000
XTANT MED HLDGS INCCOM NEW98420P30849,60272,943,918SH SOLE 72,943,91800