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Baillie Gifford & Co

Filed: 19 Oct 21, 11:25am

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X Genomics Inc Class ACL A COM88025U109291,0131,998,987SH DFND11,998,98700
10X Genomics Inc Class ACL A COM88025U109276,5031,899,319SH DFND21,773,2160126,103
10X Genomics Inc Class ACL A COM88025U109128,988886,028SH DFND3732,3980153,630
10X Genomics Inc Class ACL A COM88025U109110,392758,291SH SOLE0758,29100
1Life HealthcareCOM68269G1079445SH DFND344500
2UCOM90214J10111319SH DFND331900
8x8 IncCOM282914100512,193SH DFND32,19300
908 DevicesCOM65443P1028249SH DFND324900
ACM ResearchCOM00108J10924220SH DFND322000
AJ Gallagher & CoCOM363576109165,0161,110,096SH DFND11,110,09600
AJ Gallagher & CoCOM363576109541,0253,639,589SH DFND23,404,7060234,883
AJ Gallagher & CoCOM363576109103,283694,806SH DFND3326,8690367,937
AJ Gallagher & CoCOM363576109391,4012,633,038SH SOLE02,315,4100317,628
Abcellera Biologics IncCOM00288U10627,4371,369,135SH DFND11,369,13500
Abcellera Biologics IncCOM00288U1068,397419,028SH DFND2161,2790257,749
Abcellera Biologics IncCOM00288U10626,3371,314,213SH DFND31,022,7340291,479
Abcellera Biologics IncCOM00288U1062,769138,167SH SOLE0138,16700
AbiomedCOM003654100366,3181,125,332SH DFND11,125,33200
AbiomedCOM003654100506,6091,556,308SH DFND21,437,6070118,701
AbiomedCOM003654100154,098473,391SH DFND3345,7930127,598
AbiomedCOM003654100188,372578,679SH SOLE0525,595053,084
Acadia Pharmaceuticals IncCOM0042251089544SH DFND354400
Accelerate DiagnosticsCOM00430H1022418SH DFND341800
Accenture 'A'COMG1151C1011548SH DFND34800
Acutus MedicalCOM0051111094424SH DFND342400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10726,7135,166,864SH DFND15,166,86400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10716,0153,097,654SH DFND21,008,40202,089,252
Adaptimmune Therapeutics ADRSPONDS ADR00653A1076,6151,279,483SH DFND31,279,48300
Adaptimmune Therapeutics ADRSPONDS ADR00653A10716,9633,280,979SH SOLE03,280,97900
Adicet Bio IncCOM00700210873393,449SH DFND193,44900
Adicet Bio IncCOM00700210869188,177SH SOLE088,17700
Advanced Micro Devices IncCOM00790310744428SH DFND342800
AerovironmentCOM00807310830,257350,517SH DFND1350,51700
AerovironmentCOM00807310820,491237,385SH DFND277,6410159,744
AerovironmentCOM0080731088,61799,827SH DFND399,82700
AerovironmentCOM00807310819,039220,567SH SOLE0220,56700
Affirm Holdings Inc Class ACOM CL A00827B106255,3222,143,220SH DFND12,143,22000
Affirm Holdings Inc Class ACOM CL A00827B106333,1172,796,247SH DFND22,707,833088,414
Affirm Holdings Inc Class ACOM CL A00827B10622,004184,704SH DFND3166,746017,958
Affirm Holdings Inc Class ACOM CL A00827B106303,5142,547,756SH SOLE02,547,75600
Affirm Holdings Inc Class A - converted at IPOCOM CL A00827B10674,732627,313SH SOLE0627,31300
Affirm Holdings Inc Class B - converted at IPOCOM CL A00827B106295,9872,484,575SH SOLE02,484,57500
Agios Pharmaceuticals IncCOM00847X1049186SH DFND318600
Agora Inc ADRADS00851L10314,189489,288SH DFND1489,28800
Agora Inc ADRADS00851L1037,395255,012SH SOLE0255,01200
Albemarle CorpCOM012653101153,041698,911SH DFND1698,91100
Albemarle CorpCOM012653101450,4252,057,019SH DFND21,920,7280136,291
Albemarle CorpCOM01265310176,069347,394SH DFND3192,8550154,539
Albemarle CorpCOM012653101322,6911,473,676SH SOLE01,287,5110186,165
Alector IncCOM0144421071,37260,132SH DFND160,13200
Alector IncCOM0144421072,904127,253SH DFND2127,25300
Alector IncCOM0144421073,491152,967SH DFND3152,96700
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102147,473996,101SH DFND1996,10100
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102636,1464,296,834SH DFND23,563,3890733,445
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W10284,861573,193SH DFND3243,5540329,639
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102608,6574,111,160SH SOLE03,876,2960234,864
Align Technology IncCOM01625510116,39024,631SH DFND224,63100
Alkermes PlcCOMG017671056192SH DFND319200
Allscripts Healthcare SolutionCOM01988P10810744SH DFND374400
Alnylam PharmaceuticalsCOM02043Q107530,5222,809,819SH DFND12,809,81900
Alnylam PharmaceuticalsCOM02043Q107773,5394,096,915SH DFND23,449,4740647,441
Alnylam PharmaceuticalsCOM02043Q107254,1961,346,307SH DFND31,007,6510338,656
Alnylam PharmaceuticalsCOM02043Q107408,3482,162,743SH SOLE01,972,1800190,563
Alphabet Inc Class ACAP STK CL A02079K30512,4724,665SH DFND14,66500
Alphabet Inc Class ACAP STK CL A02079K30534,64312,958SH DFND212,95800
Alphabet Inc Class ACAP STK CL A02079K3055,7052,134SH DFND31,4560678
Alphabet Inc Class ACAP STK CL A02079K30599,22037,112SH SOLE037,11200
Alphabet Inc Class CCAP STK CL C02079K107236,78388,839SH DFND188,83900
Alphabet Inc Class CCAP STK CL C02079K107885,480332,224SH DFND2311,173021,051
Alphabet Inc Class CCAP STK CL C02079K107167,42162,815SH DFND329,589033,226
Alphabet Inc Class CCAP STK CL C02079K107513,744192,752SH SOLE0164,422028,330
Alteryx IncCOM02156B10325336SH DFND333600
Amazon.ComCOM0231351061,038,007315,980SH DFND1315,98000
Amazon.ComCOM0231351063,884,1161,182,365SH DFND2675,6990506,666
Amazon.ComCOM023135106470,789143,313SH DFND3106,607036,706
Amazon.ComCOM0231351061,982,256603,419SH SOLE0483,7570119,662
AmbarellaSHSG037AX10145,351291,200SH DFND1291,20000
AmbarellaSHSG037AX10120,198129,692SH DFND241,693087,999
AmbarellaSHSG037AX1018,13352,222SH DFND352,22200
AmbarellaSHSG037AX10115,20197,605SH SOLE097,60500
AmdocsCOMG0260210328365SH DFND336500
AmerenCOM02360810243,820540,982SH DFND1540,98200
AmerenCOM023608102981,204SH DFND21,20400
AmerenCOM0236081022,54931,463SH DFND331,46300
American Electric PowerCOM02553710147,449584,496SH DFND1584,49600
American Electric PowerCOM025537101981,202SH DFND21,20200
American Electric PowerCOM0255371012,73333,666SH DFND333,66600
American Superconductor CorpCOM03011120710,547723,370SH DFND1723,37000
American Superconductor CorpCOM03011120711,197768,000SH SOLE0768,00000
American Tower Corp REITCOM03027X1005121,930SH DFND11,93000
American Well Corp Class ACOM03044L10582090,028SH DFND190,02800
American Well Corp Class ACOM03044L1051,732190,084SH DFND2190,08400
American Well Corp Class ACOM03044L1052,026222,439SH DFND3222,43900
Amicus Therapeutics IncCOM03152W1095538SH DFND353800
Amkor TechnologyCOM031652100471,891SH DFND31,89100
Amneal Pharmaceuticals IncCOM03168L1052452SH DFND345200
Analog DevicesCOM03265410529,731177,522SH DFND1177,52200
Analog DevicesCOM0326541056303,763SH DFND2003,763
Analog DevicesCOM0326541055253,135SH DFND33,13500
Analog DevicesCOM03265410528,403169,590SH SOLE0169,59000
Anaplan Inc CommonCOM03272L10819306SH DFND330600
AnterixCOM03676C10010162SH DFND316200
Anthem IncCOM036752103185,464497,488SH DFND1497,48800
Anthem IncCOM036752103682,9531,831,955SH DFND21,711,0960120,859
Anthem IncCOM036752103133,371357,754SH DFND3168,0870189,667
Anthem IncCOM036752103487,4231,307,466SH SOLE01,144,3640163,102
AppFolioCOM03783C10029241SH DFND324100
Appian CorpCL A03782L101206,8492,235,963SH DFND12,235,96300
Appian CorpCL A03782L101252,7182,731,787SH DFND22,351,1660380,621
Appian CorpCL A03782L10127,341295,544SH DFND3295,54400
Appian CorpCL A03782L10182,628893,176SH SOLE0893,17600
AppleCOM03783310030,161213,152SH DFND1213,15200
AppleCOM0378331006484,579SH DFND2004,579
AppleCOM0378331005403,816SH DFND33,81600
AppleCOM03783310029,182206,235SH SOLE0206,23500
AptivCOMG6095L10920134SH DFND313400
Ares Capital CorpCOM04010L103102,4105,037,400SH DFND15,037,40000
Ares Capital CorpCOM04010L10321810,700SH DFND210,70000
Ares Capital CorpCOM04010L1035,901290,270SH DFND3290,27000
ArganCOM04010E1094103SH DFND310300
Ascendis Pharma ADR 1:1SPON ADR04351P1012,30714,474SH DFND114,47400
Ascendis Pharma ADR 1:1SPON ADR04351P1015,01031,431SH DFND231,43100
Ascendis Pharma ADR 1:1SPON ADR04351P1015,98237,529SH DFND337,52900
Asensus Surgical IncCOM04367G103105,338SH DFND35,33800
AstraZeneca ADRCOM04635310824400SH DFND340000
Atlassian Corp PlcCL AG06242104197,624504,889SH DFND1504,88900
Atlassian Corp PlcCL AG062421041,521,5903,887,358SH DFND21,227,12902,660,229
Atlassian Corp PlcCL AG06242104180,789461,879SH DFND3385,269076,610
Atlassian Corp PlcCL AG06242104406,4601,038,423SH SOLE0480,9160557,507
AtrionCOM04990410569SH DFND3900
Autohome Inc - ADRSP ADR RP CL A05278C10717,513373,164SH DFND1373,16400
Autohome Inc - ADRSP ADR RP CL A05278C10763,3111,349,058SH DFND21,256,642092,416
Autohome Inc - ADRSP ADR RP CL A05278C10712,502266,392SH DFND3121,6680144,724
Autohome Inc - ADRSP ADR RP CL A05278C10746,525991,370SH SOLE0869,2800122,090
AvangridCOM05351W10370,3031,446,574SH DFND11,446,57400
AvangridCOM05351W1031372,828SH DFND22,82800
AvangridCOM05351W1033,65575,212SH DFND375,21200
Avery Dennison CorporationCOM05361110923110SH DFND311000
Axogen IncCOM05463X1066,950439,900SH DFND1439,90000
Axogen IncCOM05463X1066,021381,062SH DFND2126,4870254,575
Axogen IncCOM05463X1062,703171,097SH DFND3171,09700
Axogen IncCOM05463X1062,680169,600SH SOLE0169,60000
Axon Enterprise IncCOM05464C101143,463819,697SH DFND1819,69700
Axon Enterprise IncCOM05464C101329,0131,879,860SH DFND21,620,3980259,462
Axon Enterprise IncCOM05464C10176,211435,444SH DFND3257,3420178,102
Axon Enterprise IncCOM05464C101245,6681,403,657SH SOLE01,245,9320157,725
Axonics Modulation TechnologiesCOM05465P10115230SH DFND323000
Baidu.com Sponsored ADRSPON ADR REP A05675210811,38074,017SH DFND174,01700
Baidu.com Sponsored ADRSPON ADR REP A056752108548,9213,570,217SH DFND23,260,2350309,982
Baidu.com Sponsored ADRSPON ADR REP A05675210829,332190,779SH DFND328,7990161,980
Baidu.com Sponsored ADRSPON ADR REP A0567521081,0947,113SH DFND47,11300
Baidu.com Sponsored ADRSPON ADR REP A05675210877498SH SOLE049800
Banco Bradesco Pn ADRSP ADR PFD NEW05946030316,8214,391,881SH DFND14,391,88100
Banco Bradesco Pn ADRSP ADR PFD NEW059460303130,95034,190,491SH DFND218,902,188015,288,303
Banco Bradesco Pn ADRSP ADR PFD NEW0594603036,4551,685,300SH DFND31,685,30000
BandwidthCOM05988J10326287SH DFND228700
BandwidthCOM05988J10315161SH DFND316100
Baozun Spn Adr 1:1SPONSORED ADR06684L10310,385592,408SH DFND1592,40800
Baozun Spn Adr 1:1SPONSORED ADR06684L1037,522429,093SH DFND2138,8980290,195
Baozun Spn Adr 1:1SPONSORED ADR06684L1033,256185,739SH DFND3185,73900
Baozun Spn Adr 1:1SPONSORED ADR06684L1035,156294,100SH SOLE0294,10000
Beam TherapeuticsCOM07373V10537425SH DFND342500
Beam TherapeuticsCOM07373V10589410,275SH SOLE010,27500
BeiGene LtdSPONSORED ADR07725L102140,251386,366SH DFND1386,36600
BeiGene LtdSPONSORED ADR07725L1021,075,8402,963,747SH DFND21,114,23501,849,512
BeiGene LtdSPONSORED ADR07725L102100,394276,567SH DFND3230,286046,281
BeiGene LtdSPONSORED ADR07725L102225,921622,372SH SOLE0288,7090333,663
Benefitfocus IncCOM08180D1063,402306,448SH DFND1306,44800
Benefitfocus IncCOM08180D1063,215289,682SH DFND282,0010207,681
Benefitfocus IncCOM08180D1061,309117,894SH DFND3117,89400
Benefitfocus IncCOM08180D1062,513226,368SH SOLE0226,36800
Berkeley Lights IncCOM08431010123,8571,219,671SH DFND11,219,67100
Berkeley Lights IncCOM0843101018,295424,061SH DFND2275,7950148,266
Berkeley Lights IncCOM08431010118,887965,612SH DFND3796,4000169,212
Berkeley Lights IncCOM0843101016,390326,690SH SOLE0326,69000
Beyond Meat IncCOM08862E109127,5891,212,132SH DFND11,212,13200
Beyond Meat IncCOM08862E109515,1564,894,133SH DFND21,552,30903,341,824
Beyond Meat IncCOM08862E109119,7611,137,767SH DFND3917,9010219,866
Beyond Meat IncCOM08862E109138,4421,315,239SH SOLE0639,6680675,571
Bilibili Inc ADRSPONSORED ADR09004010626,199395,941SH DFND1395,94100
Bilibili Inc ADRSPONSORED ADR09004010628,762434,662SH DFND2246,1350188,527
Bilibili Inc ADRSPONSORED ADR0900401062,04630,913SH DFND30030,913
Bilibili Inc ADRSPONSORED ADR0900401066,53898,800SH SOLE041,921056,879
BioCryst PharmaceuticalsCOM09058V103221,500SH DFND31,50000
BioNTech ADRSPONS ADS09075V102150,038549,610SH DFND1549,61000
BioNTech ADRSPONS ADS09075V1021,151,0034,216,281SH DFND21,330,14202,886,139
BioNTech ADRSPONS ADS09075V102123,709453,162SH DFND3388,406064,756
BioNTech ADRSPONS ADS09075V102307,4581,126,260SH SOLE0522,5120603,748
Biomarin Pharmaceutical IncCOM09061G101682SH DFND38200
BlacklineCOM09239B10971,656606,942SH DFND1606,94200
BlacklineCOM09239B10939,057330,826SH DFND2108,2520222,574
BlacklineCOM09239B10916,417139,059SH DFND3139,05900
BlacklineCOM09239B10933,125280,576SH SOLE0280,57600
Blackrock IncCOM09247X1011821SH DFND32100
Blink ChargingCOM09354A10011400SH DFND340000
Blue Apron Holdings IncCL A09523Q1011,092148,506SH DFND1148,50600
Bluebird Bio IncCOM09609G10016860SH DFND386000
Blueprint Medicines CorpCOM09627Y10935343SH DFND334300
Booking Holdings IncCOM09857L108117,11349,334SH DFND149,33400
Booking Holdings IncCOM09857L108358,295150,933SH DFND2140,850010,083
Booking Holdings IncCOM09857L10873,34530,897SH DFND314,793016,104
Booking Holdings IncCOM09857L108267,281112,593SH SOLE098,516014,077
Boston OmahaCOM10104410521529SH DFND352900
Box IncCOM10316T10423979SH DFND397900
Brady CorpCOM10467410612245SH DFND324500
BridgeBio Pharma IncCOM10806X1023,76780,367SH DFND180,36700
BridgeBio Pharma IncCOM10806X1028,425179,760SH DFND2179,76000
BridgeBio Pharma IncCOM10806X1029,643205,749SH DFND3205,74900
Bristol Myers SquibbCOM11012210828474SH DFND347400
British Amer.Tobacco - ADRSPONSORED ADR1104481073,35695,121SH DFND195,12100
British Amer.Tobacco - ADRSPONSORED ADR110448107531,493SH DFND31,49300
British Amer.Tobacco - ADRSPONSORED ADR1104481073,44097,492SH SOLE097,49200
Broadridge Finl.Sltn.COM11133T10383,287499,801SH DFND1499,80100
Broadridge Finl.Sltn.COM11133T103319,9121,919,777SH DFND21,799,6890120,088
Broadridge Finl.Sltn.COM11133T10359,892359,408SH DFND3170,8180188,590
Broadridge Finl.Sltn.COM11133T103217,2521,303,720SH SOLE01,144,1350159,585
Brookfield RenewableCOM11284V10540,6371,047,076SH DFND11,047,07600
Brookfield RenewableCOM11284V1051263,252SH DFND23,25200
Brookfield RenewableCOM11284V1053,21382,792SH DFND382,79200
Bumble IncCOM CL A12047B10519,992400,000SH SOLE0400,00000
Burford CapitalORD SHSG1797711011,3381,038,109SH DFND11,038,10900
Burning Rock Biotech Ltd ADRSPON ADS12233L10736,6682,050,783SH DFND12,050,78300
Burning Rock Biotech Ltd ADRSPON ADS12233L107114,3256,394,005SH DFND24,718,69001,675,315
Burning Rock Biotech Ltd ADRSPON ADS12233L1073,855215,592SH DFND337,8800177,712
Burning Rock Biotech Ltd ADRSPON ADS12233L1072,356131,772SH SOLE0131,77200
Butterfly Network IncCOM CL A1241551022,451234,811SH DFND1234,81100
Butterfly Network IncCOM CL A1241551023,743358,547SH DFND2358,54700
Butterfly Network IncCOM CL A1241551026,363609,500SH DFND3609,50000
Butterfly Network IncCOM CL A1241551028,479812,150SH SOLE0812,15000
C3.aiCL A12468P1045117SH DFND311700
CEVA IncCOM1572101057,624178,680SH DFND1178,68000
CEVA IncCOM1572101056,611154,930SH DFND249,4090105,521
CEVA IncCOM1572101052,70363,354SH DFND363,35400
CEVA IncCOM1572101053,52082,500SH SOLE082,50000
CH Robinson WorldwideCOM NEW12541W20926,136300,409SH DFND1300,40900
CH Robinson WorldwideCOM NEW12541W2095606,439SH DFND2006,439
CH Robinson WorldwideCOM NEW12541W2094655,341SH DFND35,34100
CH Robinson WorldwideCOM NEW12541W20925,156289,151SH SOLE0289,15100
CS Disco IncCOM12632710524504SH DFND250400
Calavo Growers IncCOM1282461054113SH DFND311300
Cardlytics IncCOM14161W10521,721258,770SH DFND1258,77000
Cardlytics IncCOM14161W10518,060215,151SH DFND270,1970144,954
Cardlytics IncCOM14161W1057,45188,771SH DFND388,77100
Cardlytics IncCOM14161W10515,370183,112SH SOLE0183,11200
Cargurus IncCOM14178810924759SH DFND275900
Cargurus IncCOM14178810914431SH DFND343100
CarvanaCOM146869102395,5591,311,795SH DFND11,311,79500
CarvanaCOM1468691021,160,1563,847,435SH DFND22,426,56201,420,873
CarvanaCOM146869102126,532419,618SH DFND3307,0860112,532
CarvanaCOM146869102645,0532,139,195SH SOLE01,796,3870342,808
Castle BiosciencesCOM14843C10515225SH DFND322500
Cbre Group IncCL A12504L109155,0421,592,457SH DFND11,592,45700
Cbre Group IncCL A12504L109489,6395,029,156SH DFND24,710,1030319,053
Cbre Group IncCL A12504L10993,946964,932SH DFND3462,0320502,900
Cbre Group IncCL A12504L109344,1423,534,736SH SOLE03,100,0320434,704
Cellectis ADRSPONS ADS15117K1039,162726,605SH DFND1726,60500
Cellectis ADRSPONS ADS15117K1032,136169,420SH DFND2169,42000
Cellectis ADRSPONS ADS15117K1032,276180,500SH SOLE0180,50000
Celsius HoldingsCOM15118V20723260SH DFND326000
Cemex ADRSPON ADR NEW15129088937,6805,255,166SH DFND15,255,16600
Cemex ADRSPON ADR NEW151290889196,70427,434,341SH DFND211,161,053016,273,288
Cemex ADRSPON ADR NEW15129088962,1118,662,679SH DFND31,243,28607,419,393
Cemex ADRSPON ADR NEW1512908892,538353,925SH DFND4353,92500
CertaraCOM15687V10953,7731,624,567SH DFND11,624,56700
CertaraCOM15687V109185,1985,595,107SH DFND24,997,3040597,803
CertaraCOM15687V10937,2461,125,255SH DFND3535,7520589,503
CertaraCOM15687V109142,5984,308,086SH SOLE03,787,9030520,183
CerusCOM15708510171,143SH DFND31,14300
ChargePoint Holdings IncCOM CL A15961R1051276,341SH DFND16,34100
ChargePoint Holdings IncCOM CL A15961R10591,4534,574,933SH SOLE04,574,93300
CheggCOM163092109401,3055,899,810SH DFND15,899,81000
CheggCOM163092109554,7948,156,336SH DFND27,313,4290842,907
CheggCOM16309210982,8351,217,810SH DFND3911,3360306,474
CheggCOM163092109219,5273,227,389SH SOLE03,003,1480224,241
Chewy IncCL A16679L109203,7892,992,058SH DFND12,992,05800
Chewy IncCL A16679L109274,7094,033,312SH DFND23,901,7810131,531
Chewy IncCL A16679L10913,380196,449SH DFND3196,44900
Chewy IncCL A16679L10942,597625,420SH SOLE0625,42000
Chinook TherapeuticsCOM16961L1065,055396,187SH DFND1396,18700
Chinook TherapeuticsCOM16961L1062,857223,878SH DFND277,8150146,063
Chinook TherapeuticsCOM16961L1061,282100,453SH DFND3100,45300
Chinook TherapeuticsCOM16961L1061,494117,058SH SOLE0117,05800
Church & Dwight Co IncCOM17134010215179SH DFND317900
Cisco SystemsCOM17275R10218,680343,198SH DFND1343,19800
Cisco SystemsCOM17275R1023957,263SH DFND2007,263
Cisco SystemsCOM17275R1023346,128SH DFND36,12800
Cisco SystemsCOM17275R10218,014330,966SH SOLE0330,96600
Clear Secure IncCOM18467V10941,0501,000,000SH SOLE01,000,00000
Cloudera IncCOM18914U1007428SH DFND342800
Cloudflare IncCL A COM18915M107547,8254,863,068SH DFND14,863,06800
Cloudflare IncCL A COM18915M1071,911,86216,971,699SH DFND210,054,74106,916,958
Cloudflare IncCL A COM18915M107215,8101,915,755SH DFND31,461,9370453,818
Cloudflare IncCL A COM18915M107674,1455,984,420SH SOLE04,258,38101,726,039
Clover Health Investments CorpCOM CL A18914F10338,0015,142,177SH SOLE05,142,17700
CoStar GroupCOM22160N109305,7823,553,124SH DFND13,553,12400
CoStar GroupCOM22160N109529,4676,152,305SH DFND25,883,3570268,948
CoStar GroupCOM22160N10953,279619,086SH DFND3393,3880225,698
CoStar GroupCOM22160N109190,4052,212,465SH SOLE02,017,1110195,354
Coca ColaCOM19121610019,191365,761SH DFND1365,76100
Coca ColaCOM19121610056010,677SH DFND20010,677
Coca ColaCOM1912161003827,271SH DFND37,27100
Coca ColaCOM19121610025,289481,962SH SOLE0481,96200
CodexisCOM19200510655,0052,364,796SH DFND12,364,79600
CodexisCOM19200510646,1931,985,960SH DFND2744,76601,241,194
CodexisCOM19200510621,351917,928SH DFND3868,361049,567
CodexisCOM19200510631,4041,350,139SH SOLE01,350,13900
Cognyte SoftwareORD SHSM251331058369SH DFND336900
Cohen & Steers IncCOM19247A10027325SH DFND332500
Coherus BioSciencesCOM19249H103261,605SH DFND31,60500
CohuCOM19257610622700SH DFND370000
Columbia Sportswear CoCOM198516106995SH DFND39500
Commscope Holding Co IncCOM20337X109201,442SH DFND31,44200
Consolidated EdisonCOM20911510454,001743,914SH DFND1743,91400
Consolidated EdisonCOM209115104971,335SH DFND21,33500
Consolidated EdisonCOM2091151042,62136,103SH DFND336,10300
Cooper Cos Inc/TheCOM21664840212,96731,373SH DFND231,37300
Copa Holdings S ACL AP3107610533,641413,383SH DFND1413,38300
Copa Holdings S ACL AP31076105281,5163,459,280SH DFND22,278,33701,180,943
Copa Holdings S ACL AP3107610561,844759,947SH DFND399,7490660,198
Copa Holdings S ACL AP310761052,28828,117SH DFND428,11700
Cornerstone Ondemand IncCOM21925Y10348838SH DFND383800
Costco Wholesale CorporationCOM22160K1052965SH DFND36500
Coupa Software IncCOM22266L10671324SH DFND332400
CoupangCL A22266T109113,5864,078,493SH DFND14,078,49300
CoupangCL A22266T109938,87033,711,665SH DFND213,247,345020,464,320
CoupangCL A22266T109105,8883,802,078SH DFND32,893,5030908,575
CoupangCL A22266T10951718,547SH DFND418,54700
CoupangCL A22266T109206,2207,404,672SH SOLE03,439,20403,965,468
Coursera IncCOM22266M104210,3936,647,502SH DFND16,647,50200
Coursera IncCOM22266M104207,2876,549,343SH DFND25,947,9210601,422
Coursera IncCOM22266M10475,8492,396,489SH DFND31,927,6150468,874
Coursera IncCOM22266M10438,8151,226,384SH SOLE01,226,38400
CredicorpCOMG2519Y1089,96789,842SH DFND189,84200
CredicorpCOMG2519Y108146,2391,318,185SH DFND2875,3750442,810
CredicorpCOMG2519Y10831,596284,805SH DFND339,0860245,719
CredicorpCOMG2519Y1081,34912,158SH DFND412,15800
CrowdStrike HoldingsCOM22788C10531125SH DFND312500
Cullen/Frost BankersCOM22989910914,457121,878SH DFND1121,87800
Cullen/Frost BankersCOM2298991093062,576SH DFND2002,576
Cullen/Frost BankersCOM2298991092592,187SH DFND32,18700
Cullen/Frost BankersCOM22989910914,125119,081SH SOLE0119,08100
CureVac N.V. - Converted at IPOCOMN2451R10591,5861,676,780SH DFND21,676,78000
Curevac N.V.COMN2451R105123,6572,263,951SH DFND21,803,0840460,867
CyberArk Software LtdSHSM2682V10840,098254,077SH DFND1254,07700
CyberArk Software LtdSHSM2682V10833,273210,829SH DFND268,9340141,895
CyberArk Software LtdSHSM2682V10813,89888,062SH DFND388,06200
CyberArk Software LtdSHSM2682V10818,168115,118SH SOLE0115,11800
DTE Energy CoCOM23333110748,151431,032SH DFND1431,03200
DTE Energy CoCOM23333110798877SH DFND287700
DTE Energy CoCOM2333311072,68224,012SH DFND324,01200
Dada Nexus Ltd ADRADS23344D10859,5812,973,115SH DFND12,973,11500
Dada Nexus Ltd ADRADS23344D10875,3133,758,131SH DFND22,535,80001,222,331
Dada Nexus Ltd ADRADS23344D1081,06553,141SH DFND353,14100
Dada Nexus Ltd ADRADS23344D10815,685782,705SH SOLE0782,70500
Darden RestaurantsCOM2371941051282SH DFND38200
DatadogCOM23804L103229,9421,626,753SH DFND11,626,75300
DatadogCOM23804L103458,2493,241,945SH DFND23,086,2890155,656
DatadogCOM23804L10355,029389,313SH DFND3222,7920166,521
DatadogCOM23804L103199,1821,409,137SH SOLE01,268,2820140,855
Deere & CoCOM244199105143,339427,789SH DFND1427,78900
Deere & CoCOM24419910542,059125,523SH DFND248,201077,322
Deere & CoCOM244199105135,814405,331SH DFND3315,487089,844
Deere & CoCOM24419910513,72740,968SH SOLE040,96800
Denali TherapeuticsCOM24823R105156,1693,095,518SH DFND13,095,51800
Denali TherapeuticsCOM24823R105211,2124,186,566SH DFND24,058,9080127,658
Denali TherapeuticsCOM24823R10522,037436,801SH DFND3398,181038,620
Denali TherapeuticsCOM24823R105367,8277,290,931SH SOLE07,290,93100
DermTechCOM24984K1059286SH DFND328600
Dexcom IncCOM252131107419,537767,175SH DFND1767,17500
Dexcom IncCOM2521311071,655,4473,027,187SH DFND2972,95902,054,228
Dexcom IncCOM252131107407,341744,872SH DFND3606,2300138,642
Dexcom IncCOM252131107443,276810,584SH SOLE0395,9200414,664
DigimarcCOM25381B1019,039262,445SH DFND1262,44500
DigimarcCOM25381B1019,959289,172SH DFND294,2990194,873
DigimarcCOM25381B1014,142120,256SH DFND3120,25600
DigimarcCOM25381B1015,328154,711SH SOLE0154,71100
DoceboCOM25609L1059,867135,151SH DFND2135,15100
DoceboCOM25609L10519267SH DFND326700
Dolby Laboratories 'A'COM25659T10713,803156,851SH DFND1156,85100
Dolby Laboratories 'A'COM25659T1072923,321SH DFND2003,321
Dolby Laboratories 'A'COM25659T1072452,789SH DFND32,78900
Dolby Laboratories 'A'COM25659T10713,125149,143SH SOLE0149,14300
DomoCOM25755410529348SH DFND334800
Doordash IncCOM25809K105276,8371,344,001SH DFND11,344,00100
Doordash IncCOM25809K105630,5443,061,189SH DFND22,897,4340163,755
Doordash IncCOM25809K10590,485439,292SH DFND3235,1890204,103
Doordash IncCOM25809K105522,2092,535,243SH SOLE02,358,5110176,732
DropboxCL A26210C10426881SH DFND388100
Dt Midstream IncCOM23345M10710,027216,850SH DFND1216,85000
Dt Midstream IncCOM23345M10720438SH DFND243800
Dt Midstream IncCOM23345M10755512,006SH DFND312,00600
Duck Creek TechnologiesSHS26412010616355SH DFND335500
Duke Realty Corporation REITCOM26441150564,9791,357,400SH DFND11,357,40000
Duke Realty Corporation REITCOM2644115051623,392SH DFND23,39200
Duke Realty Corporation REITCOM2644115053,51373,390SH DFND373,39000
Duolingo IncCL A COM26603R10679,653478,798SH DFND1478,79800
Duolingo IncCL A COM26603R106107,291644,932SH DFND2624,302020,630
Duolingo IncCL A COM26603R1065,22631,411SH DFND331,41100
Duolingo IncCL A COM26603R10618,352110,316SH SOLE0110,31600
EHang Hdgs ADRADS26853E102502,100SH DFND12,10000
EargoCOM2700871092263SH DFND326300
EcolabCOM27886510075,892363,781SH DFND1363,78100
EcolabCOM27886510032,673156,616SH DFND290,677065,939
EcolabCOM27886510072,422347,147SH DFND3270,476076,671
EcolabCOM2788651006,68932,065SH SOLE032,06500
Edwards Lifesciences CorpCOM28176E1085,73750,676SH DFND150,67600
Edwards Lifesciences CorpCOM28176E10827,164239,942SH DFND2239,94200
Edwards Lifesciences CorpCOM28176E10814,822130,927SH DFND3130,92700
Emergent Biosolutions IncCOM29089Q10519385SH DFND338500
Enphase Energy IncCOM29355A107135900SH DFND190000
Estee Lauder 'A'COM518439104112,611375,458SH DFND1375,45800
Estee Lauder 'A'COM518439104435,5681,452,232SH DFND21,364,378087,854
Estee Lauder 'A'COM51843910478,318261,122SH DFND3123,5560137,566
Estee Lauder 'A'COM518439104288,724962,638SH SOLE0843,5490119,089
EverQuote IncCOM CL A30041R10813,394718,967SH DFND1718,96700
EverQuote IncCOM CL A30041R1085,111274,364SH DFND289,2420185,122
EverQuote IncCOM CL A30041R1082,138114,740SH DFND3114,74000
EverQuote IncCOM CL A30041R1084,314231,550SH SOLE0231,55000
Everbridge IncCOM29978A10449,962330,786SH DFND1330,78600
Everbridge IncCOM29978A10431,640209,484SH DFND268,6080140,876
Everbridge IncCOM29978A10413,20187,403SH DFND387,40300
Everbridge IncCOM29978A10422,421148,446SH SOLE0148,44600
Eversource EnergyCOM30040W10844,289541,700SH DFND1541,70000
Eversource EnergyCOM30040W108921,128SH DFND21,12800
Eversource EnergyCOM30040W1082,54331,107SH DFND331,10700
Exact SciencesCOM30063P105104,0131,089,714SH DFND11,089,71400
Exact SciencesCOM30063P105160,5001,681,507SH DFND21,356,9340324,573
Exact SciencesCOM30063P10548,267505,675SH DFND3360,9150144,760
Exact SciencesCOM30063P105112,2141,175,631SH SOLE01,061,9110113,720
ExelixisCOM30161Q104251,200SH DFND31,20000
Exelon CorporationCOM30161N1011,07622,268SH DFND122,26800
Expedia Group IncCOM30212P30327165SH DFND316500
Expeditors IntlCOM30213010915126SH DFND312600
ExponentCOM30214U10227242SH DFND324200
Facebook Cl.ACL A30303M102266,276784,571SH DFND1784,57100
Facebook Cl.ACL A30303M1021,568,3994,621,228SH DFND22,268,77302,352,455
Facebook Cl.ACL A30303M102223,802659,425SH DFND3460,3140199,111
Facebook Cl.ACL A30303M102624,2661,839,378SH SOLE01,249,1780590,200
FarfetchORD SHS CL A30744W10768,6651,832,046SH DFND11,832,04600
FarfetchORD SHS CL A30744W107214,1785,714,469SH DFND25,327,0670387,402
FarfetchORD SHS CL A30744W10747,7211,273,227SH DFND3675,6820597,545
FarfetchORD SHS CL A30744W107232,2636,196,982SH SOLE05,204,9440992,038
FastenalCOM31190010452,7491,022,074SH DFND11,022,07400
FastenalCOM31190010420,032388,139SH DFND2370,349017,790
FastenalCOM3119001045,223101,192SH DFND373,992027,200
FastenalCOM31190010442,240818,452SH SOLE0818,45200
FastlyCL A31188V1008205SH DFND320500
Ferrari NVCOMN3167Y1031,848,6708,815,282SH DFND27,211,27601,604,006
Ferrari NVCOMN3167Y103285,1921,359,921SH SOLE01,359,92100
Fibrogen IncCOM31572Q8085467SH DFND346700
First Industrial REITCOM32054K10363,7671,224,400SH DFND11,224,40000
First Industrial REITCOM32054K1031593,053SH DFND23,05300
First Industrial REITCOM32054K1033,44566,148SH DFND366,14800
First Majestic SilverCOM32076V103928,100SH DFND28,10000
First Republic BankCOM33616C100351,0801,820,198SH DFND11,820,19800
First Republic BankCOM33616C100493,4682,558,419SH DFND22,484,887073,532
First Republic BankCOM33616C10032,384167,898SH DFND3150,481017,417
First Republic BankCOM33616C10071,266369,482SH SOLE0369,48200
FirstCashCOM33767D10517,773203,120SH DFND1203,12000
FirstCashCOM33767D1051,00311,467SH DFND311,46700
Fiverr IntlORD SHSM4R82T1061161SH DFND36100
FortisCOM3495531071,35130,457SH DFND130,45700
Fortive CorpCOM34959J1086,90397,814SH DFND297,81400
FoxCOM35137L10514359SH DFND335900
Freshpet IncCOM35803910528196SH DFND219600
Full Truck Alliance - converted at IPOSPONS ADS35969L10895,951125,181,008SH SOLE0125,181,00800
Full Truck Alliance Co Ltd ADRSPONS ADS35969L108246,43816,075,519SH DFND215,898,2330177,286
Futu Hdgs ADRSPON ADR CL A36118L10692,5491,016,800SH DFND2799,7000217,100
GANCOMG3728V1099572SH DFND357200
Gentex CorpCOM37190110917516SH DFND351600
Ginkgo Bioworks Holdings IncCL A COM37611X10046,1683,983,452SH DFND13,983,45200
Ginkgo Bioworks Holdings IncCL A COM37611X10060,6175,230,080SH DFND25,210,788019,292
Ginkgo Bioworks Holdings IncCL A COM37611X1003,036261,983SH DFND3261,98300
Ginkgo Bioworks Holdings IncCL A COM37611X100944,90181,527,295SH SOLE081,527,29500
Glaukos CorpCOM37732210236,690761,687SH DFND1761,68700
Glaukos CorpCOM37732210247,140978,619SH DFND2949,707028,912
Glaukos CorpCOM3773221026,928143,822SH DFND3135,64808,174
Glaukos CorpCOM3773221026,561136,197SH SOLE0136,19700
Global Blood Therapeutics IncCOM37890U10821835SH DFND383500
Golub Capital BDC IncCOM38173M10221,0701,332,700SH DFND11,332,70000
Golub Capital BDC IncCOM38173M102483,018SH DFND23,01800
Golub Capital BDC IncCOM38173M1021,21176,612SH DFND376,61200
Goodyear Tire & Rubber Co/TheCOM382550101251,400SH DFND31,40000
GracoCOM38410910425363SH DFND336300
Grainger, WWCOM3848021042359SH DFND35900
HDFC Bank ADRADR REPS 3 SHS40415F1014,50961,687SH DFND161,68700
HDFC Bank ADRADR REPS 3 SHS40415F10163,545869,411SH DFND2804,937064,474
HDFC Bank ADRADR REPS 3 SHS40415F10115,086206,407SH DFND3120,627085,780
HDFC Bank ADRADR REPS 3 SHS40415F10185,8751,174,926SH SOLE01,071,6340103,292
HUYA ADRADS REP SHS A44852D10814,4491,732,547SH DFND11,732,54700
HUYA ADRADS REP SHS A44852D10837,3634,479,938SH DFND22,413,09702,066,841
HUYA ADRADS REP SHS A44852D1083,346401,194SH DFND333,1650368,029
HUYA ADRADS REP SHS A44852D1088,4991,019,065SH SOLE01,019,06500
Halozyme TherapeuticsCOM40637H10936880SH DFND388000
Harris CorpCOM5024311091361SH DFND36100
Health Catalyst IncCOM42225T1073,29465,863SH DFND165,86300
Health Catalyst IncCOM42225T1077,341146,800SH DFND2146,80000
Health Catalyst IncCOM42225T1078,419168,340SH DFND3168,34000
Healthcare Services Group IncCOM4219061084157SH DFND315700
Hecla Mining CoCOM4227041069216,700SH DFND216,70000
Heron Therapeutics IncCOM4277461023308SH DFND330800
HillenbrandCOM4315711087170SH DFND317000
Home DepotCOM4370761021856SH DFND35600
Homology MedicinesCOM4380831074481SH DFND348100
Howard HughesCOM44267D10751,412585,486SH DFND1585,48600
Howard HughesCOM44267D107128,3141,461,271SH DFND21,362,861098,410
Howard HughesCOM44267D10726,410300,767SH DFND3145,5040155,263
Howard HughesCOM44267D10796,2111,095,670SH SOLE0967,4710128,199
HubbellCOM4435106071687SH DFND38700
Hubspot IncCOM44357310089132SH DFND313200
HumanaCOM4448591022256SH DFND35600
Hutchison China MeditechSPONSORED ADR44842L1034,521123,500SH DFND1123,50000
Hutchison China MeditechSPONSORED ADR44842L1032,22660,804SH DFND2124060,680
Hutchison China MeditechSPONSORED ADR44842L1036,724183,661SH DFND3720183,589
ICICI Bank ADRADR45104G104168,6288,936,327SH DFND18,936,32700
ICICI Bank ADRADR45104G104183,7309,736,631SH DFND29,095,1600641,471
ICICI Bank ADRADR45104G10473,2873,883,789SH DFND32,679,25001,204,539
ICICI Bank ADRADR45104G1047,545399,861SH DFND4399,86100
ICICI Bank ADRADR45104G104186,5689,887,005SH SOLE08,628,52601,258,479
IPG Photonics CorpCOM44980X10919,126120,747SH DFND1120,74700
IPG Photonics CorpCOM44980X10917,970113,449SH DFND237,181076,268
IPG Photonics CorpCOM44980X1097,48547,252SH DFND347,25200
IPG Photonics CorpCOM44980X10914,30990,336SH SOLE090,33600
Iac/InteractivecorpCOM44891N20829,361225,349SH DFND1225,34900
Iac/InteractivecorpCOM44891N20896,732742,436SH DFND2687,927054,509
Iac/InteractivecorpCOM44891N20821,123162,123SH DFND376,365085,758
Iac/InteractivecorpCOM44891N20876,374586,183SH SOLE0515,433070,750
Iclick Interactive Asia GSPON ADR45113Y10419,7373,569,062SH DFND13,569,06200
Iclick Interactive Asia GSPON ADR45113Y1045,6391,019,641SH DFND21,019,64100
Iclick Interactive Asia GSPON ADR45113Y10425846,694SH DFND346,69400
Iclick Interactive Asia GSPON ADR45113Y1043,824691,490SH SOLE0691,49000
Ii-Vi IncCOM90210410832533SH DFND353300
IlluminaCOM452327109856,8732,112,554SH DFND12,112,55400
IlluminaCOM4523271094,594,32711,326,958SH DFND27,805,08903,521,869
IlluminaCOM452327109483,9321,193,097SH DFND3943,4660249,631
IlluminaCOM4523271092,432,0565,996,046SH SOLE05,300,8900695,156
InModeSHSM5425M10349308SH DFND330800
Incyte CorpCOM45337C10211165SH DFND316500
InfineraCOM45667G103242,941SH DFND32,94100
Infosys Ltd ADRSPONSORED ADR45678810826,5111,191,515SH DFND11,191,51500
Infosys Ltd ADRSPONSORED ADR45678810820,791934,422SH DFND289,0630845,359
Infosys Ltd ADRSPONSORED ADR45678810816,318733,384SH DFND3610,9670122,417
Infosys Ltd ADRSPONSORED ADR4567881083,403152,945SH DFND4152,94500
Inogen IncCOM45780L1046141SH DFND314100
Insmed IncCOM45766930719707SH DFND370700
Inspire Medical SystemsCOM45773010940170SH DFND317000
Intercept Pharmaceuticals IncCOM45845P1081101SH DFND310100
International Game TechnologySHSG4863A108291,100SH DFND31,10000
Intersect ENTCOM46071F10312440SH DFND344000
Intuitive SurgicalCOM NEW46120E602129,299130,060SH DFND1130,06000
Intuitive SurgicalCOM NEW46120E602991,605997,440SH DFND2313,8110683,629
Intuitive SurgicalCOM NEW46120E602115,034115,711SH DFND395,926019,785
Intuitive SurgicalCOM NEW46120E602264,923266,482SH SOLE0123,5420142,940
InvitaeCOM46185L10323800SH DFND380000
Ionis PharmaceuticalsCOM4622221001,76652,652SH DFND152,65200
Ionis PharmaceuticalsCOM4622221003,803113,397SH DFND2113,39700
Ionis PharmaceuticalsCOM4622221004,560135,954SH DFND3135,95400
Ironwood Pharmaceuticals IncCOM46333X10812935SH DFND393500
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210615,6102,962,059SH DFND12,962,05900
Itau Unibanco Holding SA-ADRSPON ADR REP PFD465562106198,45837,658,110SH DFND224,525,687013,132,423
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210649,0489,307,029SH DFND31,230,27608,076,753
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621062,030385,212SH DFND4385,21200
Itron IncCOM46574110615204SH DFND320400
J&J Snack Foods CorpCOM4660321091383SH DFND38300
JD.Com Inc - ADRSPON ADR CL A47215P106100,1421,386,239SH DFND11,386,23900
JD.Com Inc - ADRSPON ADR CL A47215P1064,94068,377SH DFND268,37700
JD.Com Inc - ADRSPON ADR CL A47215P106771,066SH DFND31,06600
JD.Com Inc - ADRSPON ADR CL A47215P10621,090291,937SH SOLE0291,93700
JDS Uniphase CorporationCOM925550105181,142SH DFND31,14200
JFrog LtdORD SHSM6191J10017,504522,500SH DFND1522,50000
JFrog LtdORD SHSM6191J1009,692289,316SH DFND294,5290194,787
JFrog LtdORD SHSM6191J1004,111122,707SH DFND3122,70700
JFrog LtdORD SHSM6191J10011,993358,000SH SOLE0358,00000
Jack Henry & AssociatesCOM4262811011271SH DFND37100
Jackson Financial CDICOM CL A46817M10752720,266SH DFND120,26600
Jackson Financial CDICOM CL A46817M1072098,026SH DFND28,02600
Jackson Financial CDICOM CL A46817M1072369,080SH DFND36,18502,895
Jackson Financial CDICOM CL A46817M10714535SH SOLE053500
Jaguar Health - US indemnity sharesCOM47010C40902,033,592SH SOLE02,033,59200
Joby Aviation IncCOMG6516310077,2337,677,200SH SOLE07,677,20000
John Wiley & Sons IncCOM9682232068153SH DFND315300
Johnson & JohnsonCOM4781601041489SH DFND38900
Jumia Technologies Ag ADRSPONSORED ADS48138M105176,3929,488,528SH DFND29,064,5850423,943
Jumia Technologies Ag ADRSPONSORED ADS48138M1057374SH DFND337400
KE Holdings ADRADR48249710439,7902,179,095SH DFND12,179,09500
KE Holdings ADRADR482497104234,18612,825,059SH DFND26,313,22006,511,839
KE Holdings ADRADR48249710418,172995,165SH DFND3729,5400265,625
KE Holdings ADRADR48249710488,3324,837,457SH SOLE03,707,21301,130,244
Kaleido Biosciences IncCOM4833471002,011368,288SH DFND1368,28800
Kaleido Biosciences IncCOM483347100101,836SH DFND21,83600
Kaleido Biosciences IncCOM4833471001,579289,103SH SOLE0289,10300
Keysight TechnologiesCOM49338L10326158SH DFND315800
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10156,1971,984,362SH DFND11,984,36200
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K101103,5903,657,847SH DFND22,367,80901,290,038
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1019,250326,627SH DFND342,7580283,869
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10111,134393,153SH SOLE0393,15300
Knowles CorpCOM49926D109221,200SH DFND31,20000
Korea Electric Power ADRSPONSORED ADR500631106222,224SH DFND22,22400
Korea Electric Power ADRSPONSORED ADR5006311061,593161,422SH DFND3161,42200
Kulicke & Soffa Industries IncCOM50124210129491SH DFND349100
Lci IndustriesCOM50189K1031286SH DFND38600
Lemonade IncCOM52567D107114,7801,712,881SH DFND11,712,88100
Lemonade IncCOM52567D107156,9642,342,398SH DFND22,266,258076,140
Lemonade IncCOM52567D1077,426110,822SH DFND3110,82200
Lemonade IncCOM52567D10757,868863,575SH SOLE0863,57500
LendingTreeCOM52603B10743,054307,900SH DFND1307,90000
LendingTreeCOM52603B10771,817513,605SH DFND2359,7550153,850
LendingTreeCOM52603B10722,284159,363SH DFND3121,573037,790
LendingTreeCOM52603B10746,011329,049SH SOLE0303,218025,831
Li Auto ADRSPONS ADS50202M10249,7461,892,209SH DFND11,892,20900
Li Auto ADRSPONS ADS50202M102173,6056,603,449SH DFND25,894,4450709,004
Li Auto ADRSPONS ADS50202M10234,8401,325,200SH DFND3619,6860705,514
Li Auto ADRSPONS ADS50202M102130,8144,975,791SH SOLE04,368,7300607,061
Liberty Broadband CorpCOM5303073051270SH DFND37000
Lightspeed POSCOM53227R10630310SH DFND331000
Lilium NVCL A COMN52586109615,800SH DFND15,80000
Lilium NVCL A COMN52586109186,02317,699,615SH SOLE017,699,61500
LivePerson IncCOM53814610129,021492,291SH DFND1492,29100
LivePerson IncCOM53814610122,112375,103SH DFND2122,4430252,660
LivePerson IncCOM5381461019,239156,733SH DFND3156,73300
LivePerson IncCOM53814610114,613247,880SH SOLE0247,88000
Liveramp Holdings IncCOM53815P10829,065615,401SH DFND1615,40100
Liveramp Holdings IncCOM53815P10815,260323,108SH DFND2105,8620217,246
Liveramp Holdings IncCOM53815P1086,533138,318SH DFND3138,31800
Liveramp Holdings IncCOM53815P10813,936295,075SH SOLE0295,07500
Logitech International SASHSH5043023221235SH DFND323500
Lowes CosCOM5486611071469SH DFND36900
Lufax Holding LtdCOM54975P10246,8656,714,184SH DFND16,714,18400
Lufax Holding LtdCOM54975P10283,98212,031,797SH DFND26,999,49605,032,301
Lufax Holding LtdCOM54975P102943135,102SH DFND3135,10200
Lufax Holding LtdCOM54975P1025,603802,735SH SOLE0802,73500
Lumentum HdgsCOM55024U10912141SH DFND314100
Lyell Immunopharma IncCOM55083R1041,09974,223SH DFND174,22300
Lyell Immunopharma IncCOM55083R1042,451165,597SH DFND2165,59700
Lyell Immunopharma IncCOM55083R1042,777187,663SH DFND3187,66300
Lyft Inc Class A CommonCL A COM55087P10457,5901,074,643SH DFND11,074,64300
Lyft Inc Class A CommonCL A COM55087P104183,1343,417,315SH DFND23,194,1000223,215
Lyft Inc Class A CommonCL A COM55087P10435,854669,048SH DFND3324,7650344,283
Lyft Inc Class A CommonCL A COM55087P104130,4152,433,566SH SOLE02,141,4190292,147
MELI Kaszek PioneerCL A COMG5S74L10622,1002,000,000SH DFND22,000,00000
MakeMyTripSHSV5633W10966,9622,462,730SH DFND21,842,0770620,653
Marathon Digital HoldingsCOM56578810611343SH DFND334300
Markel CorpCOM57053510462,44352,248SH DFND152,24800
Markel CorpCOM570535104228,553191,237SH DFND2178,563012,674
Markel CorpCOM57053510444,95037,611SH DFND317,622019,989
Markel CorpCOM570535104166,941139,684SH SOLE0122,717016,967
MarketAxess HoldingsCOM57060D108251,753598,428SH DFND1598,42800
MarketAxess HoldingsCOM57060D108353,973841,410SH DFND2708,6050132,805
MarketAxess HoldingsCOM57060D10852,104123,853SH DFND3114,74609,107
MarketAxess HoldingsCOM57060D10880,277190,823SH SOLE0190,82300
Martin Marietta MaterialsCOM573284106176,172515,606SH DFND1515,60600
Martin Marietta MaterialsCOM573284106588,8211,723,310SH DFND21,610,8570112,453
Martin Marietta MaterialsCOM573284106107,286313,996SH DFND3161,4990152,497
Martin Marietta MaterialsCOM573284106409,8411,199,489SH SOLE01,046,5380152,951
Masimo CorpCOM5747951004,06315,009SH DFND115,00900
Masimo CorpCOM5747951008,84932,688SH DFND232,68800
Masimo CorpCOM57479510010,46938,671SH DFND338,67100
Mastercard Inc-Class ACL A57636Q104145,825419,424SH DFND1419,42400
Mastercard Inc-Class ACL A57636Q104524,9431,509,846SH DFND21,416,932092,914
Mastercard Inc-Class ACL A57636Q104100,215288,240SH DFND3138,3510149,889
Mastercard Inc-Class ACL A57636Q104356,5051,025,383SH SOLE0898,7060126,677
McDonald'sCOM58013510117,18071,253SH DFND171,25300
McDonald'sCOM5801351015102,115SH DFND2002,115
McDonald'sCOM5801351013431,423SH DFND31,42300
McDonald'sCOM58013510122,74194,316SH SOLE094,31600
Medifast IncCOM58470H10121110SH DFND311000
MedtronicCOMG5960L10319,503155,588SH DFND1155,58800
MedtronicCOMG5960L1034243,382SH DFND2003,382
MedtronicCOMG5960L1033452,755SH DFND32,75500
MedtronicCOMG5960L10319,022151,755SH SOLE0151,75500
MercadoLibreCOM58733R102503,059299,547SH DFND1299,54700
MercadoLibreCOM58733R1026,481,6833,859,523SH DFND23,235,9400623,583
MercadoLibreCOM58733R102275,947164,313SH DFND3135,528028,785
MercadoLibreCOM58733R1029,8805,883SH DFND45,88300
MercadoLibreCOM58733R102626,495373,047SH SOLE0373,04700
Mettler-ToledoCOM592688105129,05393,696SH DFND193,69600
Mettler-ToledoCOM592688105585,760425,277SH DFND2301,2610124,016
Mettler-ToledoCOM5926881055,2793,833SH DFND33,83300
Mettler-ToledoCOM59268810537,09426,931SH SOLE026,93100
MicrosoftCOM594918104277,747985,197SH DFND1985,19700
MicrosoftCOM594918104885,9373,142,513SH DFND22,947,7290194,784
MicrosoftCOM594918104163,001578,183SH DFND3275,7140302,469
MicrosoftCOM594918104626,2912,221,519SH SOLE01,964,3260257,193
Mobile Telesystems ADRSPONSORED ADR60740910928629,700SH DFND129,70000
Moderna IncCOM60770K1071,909,2654,960,933SH DFND14,960,93300
Moderna IncCOM60770K1079,229,08623,980,373SH DFND218,008,29105,972,082
Moderna IncCOM60770K107941,3462,445,944SH DFND31,893,6060552,338
Moderna IncCOM60770K1074,168,07410,830,104SH SOLE09,633,50901,196,595
Momentive Global IncCOM78489X103211,095SH DFND31,09500
MongoDB IncCOM60937P106100213SH DFND321300
Monolithic Power Systems IncCOM6098391053470SH DFND37000
Moody's CorpCOM615369105248,115698,699SH DFND1698,69900
Moody's CorpCOM615369105903,9262,545,482SH DFND22,381,2450164,237
Moody's CorpCOM615369105174,939492,634SH DFND3232,3720260,262
Moody's CorpCOM615369105626,1451,763,243SH SOLE01,539,4850223,758
NIO Inc ADRSPON ADS62914V10675,0092,105,228SH DFND12,105,22800
NIO Inc ADRSPON ADS62914V1062,130,30459,789,603SH DFND246,015,844013,773,759
NIO Inc ADRSPON ADS62914V10669,2391,943,288SH DFND31,621,0770322,211
NIO Inc ADRSPON ADS62914V106954,48826,788,885SH SOLE024,471,82502,317,060
NV5 GlobalCOM62945V10914138SH DFND313800
NVIDIACOM67066G104496,3722,396,081SH DFND12,396,08100
NVIDIACOM67066G1042,330,43011,249,421SH DFND24,783,23406,466,187
NVIDIACOM67066G104258,9391,249,948SH DFND31,054,1030195,845
NVIDIACOM67066G1041,183,5975,713,443SH SOLE04,416,93601,296,507
Nano Dimension ADRSPONS ADS63008G20391,600SH DFND31,60000
Nanobiotix ADRCOM63009J1079,640850,841SH DFND1850,84100
Nanobiotix ADRCOM63009J1076,222549,159SH SOLE0549,15900
National Instruments CorpCOM63651810220,603525,197SH DFND1525,19700
National Instruments CorpCOM63651810244811,424SH DFND20011,424
National Instruments CorpCOM6365181023699,396SH DFND39,39600
National Instruments CorpCOM63651810219,864506,350SH SOLE0506,35000
Nektar TherapeuticsCOM640268108251,376SH DFND31,37600
NetEase.com ADRSPONSORED ADR64110W10212,668148,337SH DFND1148,33700
NetEase.com ADRSPONSORED ADR64110W1028,843103,549SH DFND22090103,340
NetEase.com ADRSPONSORED ADR64110W10212142SH DFND314200
Netflix IncCOM64110L106770,0491,261,673SH DFND11,261,67300
Netflix IncCOM64110L1062,531,6954,148,008SH DFND22,274,68001,873,328
Netflix IncCOM64110L106293,581481,012SH DFND3379,8840101,128
Netflix IncCOM64110L1061,278,4712,094,687SH SOLE01,678,7400415,947
Nevro CorpCOM64157F10318154SH DFND315400
New RelicCOM64829B10053742SH DFND374200
Newmont MiningCOM6516391061,09520,172SH DFND120,17200
NextEra EnergyCOM65339F10158,697747,548SH DFND1747,54800
NextEra EnergyCOM65339F1011231,570SH DFND21,57000
NextEra EnergyCOM65339F1013,57345,505SH DFND345,50500
NikeCOM65410610315105SH DFND310500
Novanta IncCOM67000B10432206SH DFND220600
Novocure LtdORD SHSG6674U108301,9182,598,934SH DFND12,598,93400
Novocure LtdORD SHSG6674U108494,3204,255,147SH DFND23,791,7790463,368
Novocure LtdORD SHSG6674U10880,507693,013SH DFND3518,8400174,173
Novocure LtdORD SHSG6674U108211,7331,822,611SH SOLE01,675,7950146,816
Nucana Plc ADRSPONSORED ADR67022C1066,2442,420,041SH DFND12,420,04100
Nucana Plc ADRSPONSORED ADR67022C1063,1971,238,989SH SOLE01,238,98900
Nutanix IncCOM67059N10821563SH DFND356300
Oatly Inc.SPONS ADS67421J108342,30922,639,457SH DFND219,435,97503,203,482
Oatly Inc.SPONS ADS67421J10816,0571,061,969SH SOLE01,061,96900
On Semiconductor CorpCOM68218910523500SH DFND350000
OneConnect Financial Technology ADRCOM68248T1058,4252,054,800SH DFND12,054,80000
OneConnect Financial Technology ADRCOM68248T1052,613637,316SH DFND2207,7980429,518
OneConnect Financial Technology ADRCOM68248T1051,152281,030SH DFND3281,03000
Opko Health IncCOM68375N103246,635SH DFND36,63500
Oscar Health IncCOM68779310926,8571,544,374SH DFND11,544,37400
Oscar Health IncCOM687793109114,7116,596,357SH DFND25,163,90701,432,450
Oscar Health IncCOM68779310920,7771,194,746SH DFND3616,7930577,953
Oscar Health IncCOM68779310989,6485,155,120SH SOLE04,662,5110492,609
Outset MedicalCOM69014510717346SH DFND334600
Oxford Industries IncCOM691497309773SH DFND37300
Ozon HoldingsCOM69269L10411,866235,211SH DFND1235,21100
Ozon HoldingsCOM69269L10491,4481,812,642SH DFND2996,9500815,692
Ozon HoldingsCOM69269L10469613,790SH DFND313,79000
Pacific Biosciences of CaliforniaCOM69404D10814561SH DFND356100
Pacira BioSciencesCOM69512710054,560974,287SH DFND1974,28700
Pacira BioSciencesCOM69512710028,793514,162SH DFND2228,5150285,647
Pacira BioSciencesCOM69512710015,283272,912SH DFND3241,737031,175
Pacira BioSciencesCOM69512710018,281326,446SH SOLE0326,44600
PagerDutyCOM69553P10023567SH DFND356700
Pan American Silver CorpCOM6979001081054,500SH DFND24,50000
PaychexCOM70432610713116SH DFND311600
Peloton Interactive IncCL A COM70614W100379,9864,365,150SH DFND14,365,15000
Peloton Interactive IncCL A COM70614W1001,442,51516,571,106SH DFND27,735,62508,835,481
Peloton Interactive IncCL A COM70614W100218,2882,507,616SH DFND31,963,0790544,537
Peloton Interactive IncCL A COM70614W100413,0664,745,159SH SOLE02,815,76301,929,396
Penumbra IncCOM70975L107136,974513,973SH DFND1513,97300
Penumbra IncCOM70975L107178,275668,950SH DFND2647,401021,549
Penumbra IncCOM70975L1078,85833,238SH DFND333,23800
Penumbra IncCOM70975L10728,671107,583SH SOLE0107,58300
PepsicoCOM71344810833,820224,852SH DFND1224,85200
PepsicoCOM7134481087324,865SH DFND2004,865
PepsicoCOM7134481086054,025SH DFND34,02500
PepsicoCOM71344810832,578216,594SH SOLE0216,59400
Petrobras Common ADRSPONSORED ADR71654V408185,74817,964,024SH DFND117,964,02400
Petrobras Common ADRSPONSORED ADR71654V408608,04258,804,836SH DFND228,155,161030,649,675
Petrobras Common ADRSPONSORED ADR71654V408176,20717,041,314SH DFND32,539,540014,501,774
Petrobras Common ADRSPONSORED ADR71654V4087,300706,010SH DFND4706,01000
Petrobras Common ADRSPONSORED ADR71654V40812,9731,254,653SH SOLE01,254,65300
Petrobras Pref ADRSP ADR NON VTG71654V10119,1331,913,345SH DFND11,913,34500
Petrobras Pref ADRSP ADR NON VTG71654V101134,20513,420,519SH DFND28,050,82405,369,695
Petrobras Pref ADRSP ADR NON VTG71654V1011,116111,646SH DFND3111,64600
PfizerCOM71708110322500SH DFND350000
Piedmont Lithium IncCOM72016P10512212SH DFND321200
Pinduoduo Inc ADRSPONSORED ADS722304102171,5331,891,837SH DFND11,891,83700
Pinduoduo Inc ADRSPONSORED ADS7223041021,591,49317,552,591SH DFND27,888,06609,664,525
Pinduoduo Inc ADRSPONSORED ADS722304102155,0941,710,531SH DFND31,439,4210271,110
Pinduoduo Inc ADRSPONSORED ADS722304102574,2636,333,551SH SOLE04,365,02201,968,529
PinterestCOM72352L106124,3502,440,626SH DFND12,440,62600
PinterestCOM72352L106174,1553,418,150SH DFND23,310,9460107,204
PinterestCOM72352L1068,224161,420SH DFND3161,42000
PinterestCOM72352L10627,723544,112SH SOLE0544,11200
Plantronics IncCOM7274931087254SH DFND325400
Precision BioSciences IncCOM74019P108171,468SH DFND21,46800
Procter & GambleCOM74271810941,222294,862SH DFND1294,86200
Procter & GambleCOM7427181098886,350SH DFND2006,350
Procter & GambleCOM7427181097365,267SH DFND35,26700
Procter & GambleCOM74271810940,587290,323SH SOLE0290,32300
ProgynyCOM74340E10322396SH DFND339600
Prologis Inc REITCOM74340W10368,899549,300SH DFND1549,30000
Prologis Inc REITCOM74340W1031701,357SH DFND21,35700
Prologis Inc REITCOM74340W1033,72329,684SH DFND329,68400
Proterra IncCOM74374T10910710,600SH DFND110,60000
Ptc Therapeutics IncCOM69366J2009246SH DFND324600
Puma BiotechnologyCOM74587V1072252SH DFND325200
Pure Storage IncCOM74624M102341,364SH DFND31,36400
Q2 Holdings IncCOM74736L10925,512318,346SH DFND1318,34600
Q2 Holdings IncCOM74736L10915,149189,034SH DFND262,0870126,947
Q2 Holdings IncCOM74736L1096,34179,125SH DFND379,12500
Q2 Holdings IncCOM74736L1099,796122,235SH SOLE0122,23500
Quaker Chemical CorpCOM7473161072086SH DFND38600
QualcommCOM74752510326200SH DFND320000
Quanterix CorpCOM74766Q10119,475391,135SH DFND1391,13500
Quanterix CorpCOM74766Q10137746SH DFND274600
Quanterix CorpCOM74766Q10110,440209,677SH SOLE0209,67700
QuantumScape CorpCOM CL A74767V109692,830SH DFND12,83000
QuantumScape CorpCOM CL A74767V10922,412913,279SH SOLE0913,27900
Quest DiagnosticsCOM74834L10021145SH DFND314500
Quidel CorpCOM74838J10118128SH DFND312800
Rambus IncCOM75091710616699SH DFND369900
Recursion Pharmaceuticals - converted at IPOCL A75629V104295,82512,856,385SH SOLE012,856,38500
Recursion Pharmaceuticals IncCL A75629V10466,9002,907,422SH DFND12,907,42200
Recursion Pharmaceuticals IncCL A75629V10492,7624,031,371SH DFND23,911,8080119,563
Recursion Pharmaceuticals IncCL A75629V10411,969520,153SH DFND3520,15300
Recursion Pharmaceuticals IncCL A75629V10440,1761,746,043SH SOLE01,746,04300
RedfinCOM75737F108207,0334,132,390SH DFND14,132,39000
RedfinCOM75737F108256,2605,114,964SH DFND24,955,1290159,835
RedfinCOM75737F10818,921377,671SH DFND3336,074041,597
RedfinCOM75737F10838,475767,961SH SOLE0767,96100
Regeneron PharmaceuticalsCOM75886F1073355SH DFND35500
Relay Therapeutics IncCOM75943R1021,20038,069SH DFND138,06900
Relay Therapeutics IncCOM75943R1022,53180,273SH DFND280,27300
Relay Therapeutics IncCOM75943R1022,98794,747SH DFND394,74700
ResMedCOM76115210799,914379,110SH DFND1379,11000
ResMedCOM761152107333,4081,265,065SH DFND21,183,666081,399
ResMedCOM76115210774,845283,989SH DFND3155,9880128,001
ResMedCOM761152107242,987921,978SH SOLE0807,8990114,079
Research in MotionCOM09228F103272,731SH DFND32,73100
Rexford Industrial Realty REITCOM76169C10063,6741,122,000SH DFND11,122,00000
Rexford Industrial Realty REITCOM76169C1001602,826SH DFND22,82600
Rexford Industrial Realty REITCOM76169C1003,43660,547SH DFND360,54700
Ringcentral IncCOM76680R20678358SH DFND335800
Ritchie Bros Auctioneers (USA)COM767744105102,4181,661,015SH DFND21,536,2800124,735
Ritchie Bros. AuctioneersCOM76774410565,6891,064,717SH DFND2603,4310461,286
Robert Half International IncCOM77032310315151SH DFND315100
RokuCOM CL A77543R102431,1211,375,845SH DFND11,375,84500
RokuCOM CL A77543R102594,3371,896,718SH DFND21,836,519060,199
RokuCOM CL A77543R10228,41490,679SH DFND390,67900
RokuCOM CL A77543R10290,936290,207SH SOLE0290,20700
Rollins IncCOM77571110420562SH DFND356200
Royal Caribbean CruisesCOMV7780T10315,858178,276SH DFND1178,27600
Royal Caribbean CruisesCOMV7780T10389510,063SH DFND310,06300
Rubius Therapeutics IncCOM78116T10315,860887,000SH DFND1887,00000
Rubius Therapeutics IncCOM78116T1032,735152,937SH DFND257,890095,047
Rubius Therapeutics IncCOM78116T1031,22268,336SH DFND368,33600
Rubius Therapeutics IncCOM78116T10364,1103,585,559SH SOLE03,585,55900
Ryanair ADRSPONSORED ADR NE78351320356,255511,127SH DFND1511,12700
Ryanair ADRSPONSORED ADR NE7835132031,100,0789,995,255SH DFND28,744,84601,250,409
Ryanair ADRSPONSORED ADR NE78351320314,060127,744SH DFND352,924074,820
Ryanair ADRSPONSORED ADR NE78351320315,777143,348SH SOLE0112,148031,200
S&P Global IncCOM78409V104101,244238,284SH DFND1238,28400
S&P Global IncCOM78409V104371,659874,717SH DFND2819,873054,844
S&P Global IncCOM78409V10470,206165,234SH DFND378,325086,909
S&P Global IncCOM78409V104259,354610,403SH SOLE0535,067075,336
SCP Pool CorporationCOM73278L1053376SH DFND37600
SEA Ltd ADRADR81141R100696,9762,186,730SH DFND12,186,73000
SEA Ltd ADRADR81141R1001,445,8304,536,223SH DFND23,743,3360792,887
SEA Ltd ADRADR81141R100188,472591,323SH DFND3288,7900302,533
SEA Ltd ADRADR81141R100740,4982,323,276SH SOLE02,069,0380254,238
Saba Capital Income & Opportunities FundSH BEN INT92913A1001,013222,592SH DFND1222,59200
Saba Capital Income & Opportunities FundSH BEN INT92913A100956210,200SH DFND3210,20000
Sage Therapeutics IncCOM78667J10864514,553SH DFND114,55300
Sage Therapeutics IncCOM78667J1081,45732,882SH DFND232,88200
Sage Therapeutics IncCOM78667J1081,72238,863SH DFND338,86300
Sailpoint Technologies HoldingCOM78781P10517388SH DFND338800
Salesforce.comCOM79466L302118,062435,301SH DFND1435,30100
Salesforce.comCOM79466L302920,2473,392,992SH DFND21,118,42802,274,564
Salesforce.comCOM79466L302102,454377,751SH DFND3312,045065,706
Salesforce.comCOM79466L302240,053885,087SH SOLE0409,8760475,211
Sana Biotechnology IncCOM79956610446,8422,080,021SH DFND12,080,02100
Sana Biotechnology IncCOM79956610464,3222,856,227SH DFND22,856,22700
Sana Biotechnology IncCOM7995661044,363193,717SH DFND3193,71700
Sana Biotechnology IncCOM799566104136,4686,059,867SH SOLE06,059,86700
Sarepta Therapeutics IncCOM80360710016177SH DFND317700
SchrodingerCOM80810D10313242SH DFND324200
Schweitzer-Maudit Int.COM8085411069265SH DFND326500
Seagen IncCOM81181C10422128SH DFND312800
SeerCOM CL A81578P1068223SH DFND322300
Sei Investments CoCOM78411710324400SH DFND340000
Service Corp.Intl.COM817565104138,3022,295,092SH DFND12,295,09200
Service Corp.Intl.COM817565104499,7348,292,962SH DFND27,762,2150530,747
Service Corp.Intl.COM81756510495,9501,592,259SH DFND3749,7320842,527
Service Corp.Intl.COM817565104352,7525,853,829SH SOLE05,121,4420732,387
Shake Shack IncCOM81904710114174SH DFND317400
Sherwin-Williams CoCOM82434810612,43544,453SH DFND244,45300
ShockWave Medical IncCOM82489T10435,396171,923SH DFND1171,92300
ShockWave Medical IncCOM82489T10440,310195,793SH DFND2112,489083,304
ShockWave Medical IncCOM82489T10427,831135,181SH DFND3135,18100
ShockWave Medical IncCOM82489T10417,68385,892SH SOLE085,89200
Shopify 'A'CL A82509L1071,527,2161,126,448SH DFND11,126,44800
Shopify 'A'CL A82509L1074,002,4132,952,111SH DFND22,003,5520948,559
Shopify 'A'CL A82509L107497,163366,699SH DFND3275,379091,320
Shopify 'A'CL A82509L1071,409,3921,039,543SH SOLE0850,5240189,019
Shopify IncCOM82509L10713,1669,702SH DFND29,70200
Shopify IncCOM82509L107252186SH DFND318600
Silicon Laboratories IncCOM82691910218127SH DFND312700
Silicon Motion Technology ADRCOM82706C10822,541326,775SH DFND1326,77500
Silicon Motion Technology ADRCOM82706C1083765,450SH DFND2005,450
Silicon Motion Technology ADRCOM82706C1084025,827SH DFND35,82700
Silicon Motion Technology ADRCOM82706C10821,636313,651SH SOLE0313,65100
Silk Road MedicalCOM82710M10013235SH DFND323500
SiteOne Landscape SupplyCOM82982L10396,953486,052SH DFND1486,05200
SiteOne Landscape SupplyCOM82982L103337,2581,690,773SH DFND21,578,4810112,292
SiteOne Landscape SupplyCOM82982L10367,987340,837SH DFND3160,8870179,950
SiteOne Landscape SupplyCOM82982L103243,6031,221,249SH SOLE01,067,5680153,681
Six Flags Entertainment CorpCOM83001A10215,516365,090SH DFND1365,09000
Six Flags Entertainment CorpCOM83001A10287620,611SH DFND320,61100
Sixth Street Specialty LendingCOM83012A1094,779215,169SH DFND1215,16900
Sixth Street Specialty LendingCOM83012A10912530SH DFND253000
Sixth Street Specialty LendingCOM83012A10927512,379SH DFND312,37900
SmartsheetCOM83200N10321311SH DFND331100
Snap IncCL A83304A106145,4841,969,462SH DFND11,969,46200
Snap IncCL A83304A106199,0692,694,857SH DFND22,608,498086,359
Snap IncCL A83304A1069,552129,309SH DFND3129,30900
Snap IncCL A83304A10632,333437,707SH SOLE0437,70700
Snowflake IncCOM833445109240,161794,106SH DFND1794,10600
Snowflake IncCOM833445109455,0561,504,666SH DFND21,430,121074,545
Snowflake IncCOM83344510956,331186,262SH DFND3107,599078,663
Snowflake IncCOM833445109444,1741,468,685SH SOLE01,402,835065,850
Sohu.comCOM83410S1084,171200,140SH DFND300200,140
Solaredge Technologies IncCOM83417M1043821,442SH DFND11,44200
Solaredge Technologies IncCOM83417M10444167SH DFND316700
Sorrento TherapeuticsCOM83587F202334,314SH DFND34,31400
Spire Global IncCOM CL A84856010810,852866,045SH SOLE0866,04500
Splunk IncCOM84863710414,607100,940SH DFND1100,94000
Splunk IncCOM84863710420,126139,078SH DFND244,915094,163
Splunk IncCOM8486371048,41758,168SH DFND358,16800
Splunk IncCOM84863710410,69273,884SH SOLE073,88400
Spotify Technology SASHSL8681T102298,6631,325,389SH DFND11,325,38900
Spotify Technology SASHSL8681T1023,910,03717,351,723SH DFND212,815,64404,536,079
Spotify Technology SASHSL8681T102118,629526,444SH DFND3400,2940126,150
Spotify Technology SASHSL8681T102705,3113,129,988SH SOLE02,638,0160491,972
Sprout SocialCOM85209W10939,155321,078SH DFND1321,07800
Sprout SocialCOM85209W10922,071180,986SH DFND258,8580122,128
Sprout SocialCOM85209W1098,96173,478SH DFND373,47800
Sprout SocialCOM85209W10924,350199,670SH SOLE0199,67000
Staar SurgicalCOM PAR $0.01852312305191,0091,486,107SH DFND11,486,10700
Staar SurgicalCOM PAR $0.01852312305255,2621,986,012SH DFND21,515,5980470,414
Staar SurgicalCOM PAR $0.0185231230574,886582,635SH DFND3414,1730168,462
Staar SurgicalCOM PAR $0.01852312305181,1331,409,265SH SOLE01,289,9840119,281
Stamps.ComCOM NEW8528572001647SH DFND34700
Stanley Black & DeckerCOM8545021011377SH DFND37700
Starbucks CorpCOM85524410916,060145,588SH DFND1145,58800
Starbucks CorpCOM8552441092682,429SH DFND2002,429
Starbucks CorpCOM8552441092101,908SH DFND31,90800
Starbucks CorpCOM85524410916,386148,543SH SOLE0148,54300
Stericycle IncCOM85891210841,023603,539SH DFND1603,53900
Stericycle IncCOM858912108147,7982,174,455SH DFND22,031,4790142,976
Stericycle IncCOM85891210828,598420,745SH DFND3200,0430220,702
Stericycle IncCOM858912108106,3951,565,319SH SOLE01,366,2060199,113
Stitch FixCOM CL A86089710733828SH DFND282800
StoneCoCOM CL AG851581065,569160,397SH DFND1160,39700
StoneCoCOM CL AG8515810646,0831,327,279SH DFND2763,4780563,801
StoneCoCOM CL AG851581063179,131SH DFND39,13100
StoneCo Brazil DRCOM CL AG851581062446,994SH DFND36,99400
StratasysSHSM855481014,870226,300SH DFND1226,30000
StratasysSHSM855481017,760360,617SH DFND2113,5670247,050
StratasysSHSM855481013,074142,866SH DFND3142,86600
StratasysSHSM855481013,112144,600SH SOLE0144,60000
StrykerCOM8636671011454SH DFND35400
Summit Therapeutics New ListingCOM86627T1081,075214,617SH DFND1214,61700
Summit Therapeutics New ListingCOM86627T1081,112221,895SH SOLE0221,89500
Sumo LogicCOM86646P10312726SH DFND372600
Sunpower CorpCOM867652406291,269SH DFND31,26900
Sutro BiopharmaCOM86936710219,6911,042,428SH DFND11,042,42800
Sutro BiopharmaCOM869367102341,786SH DFND21,78600
Sutro BiopharmaCOM86936710214,181750,726SH SOLE0750,72600
Symantec CorpCOM66877110814554SH DFND355400
SynopsysCOM87160710734112SH DFND311200
T. Rowe PriceCOM74144T10819,36198,427SH DFND198,42700
T. Rowe PriceCOM74144T1084172,119SH DFND2002,119
T. Rowe PriceCOM74144T1083451,753SH DFND31,75300
T. Rowe PriceCOM74144T10819,34798,357SH SOLE098,35700
TAL Education Group ADRADS REPSTG COM874080104106,79922,065,841SH DFND220,827,29601,238,545
TJX CompaniesCOM8725401095,73386,893SH DFND286,89300
TSMC ADRSPONSORED ADR874039100716,0396,413,245SH DFND24,950,56901,462,676
TSMC ADRSPONSORED ADR8740391002,50622,445SH DFND322,44500
TSMC ADRSPONSORED ADR874039100108,623972,888SH SOLE0800,8140172,074
Tabula Rasa HealthCare IncCOM87337910114,708561,175SH DFND1561,17500
Tabula Rasa HealthCare IncCOM8733791014,632176,716SH DFND257,2250119,491
Tabula Rasa HealthCare IncCOM8733791011,91473,034SH DFND373,03400
Tabula Rasa HealthCare IncCOM8733791016,253238,574SH SOLE0238,57400
Tandem Diabetes CareCOM NEW87537220323,660198,192SH DFND1198,19200
Tandem Diabetes CareCOM NEW87537220335295SH DFND229500
Tandem Diabetes CareCOM NEW87537220322188SH DFND318800
Tandem Diabetes CareCOM NEW87537220317,713148,377SH SOLE0148,37700
Tata Motors Ltd ADRCOM87656850291,6694,090,544SH DFND14,090,54400
Tata Motors Ltd ADRCOM87656850270,2913,136,590SH DFND23,136,59000
Tata Motors Ltd ADRCOM8765685021,61071,835SH DFND371,83500
Tata Motors Ltd ADRCOM87656850238,1201,701,035SH SOLE01,701,03500
TeladocCOM87918A105316,8022,498,241SH DFND12,498,24100
TeladocCOM87918A105437,1943,447,628SH DFND22,942,2620505,366
TeladocCOM87918A105150,3261,185,439SH DFND3892,5940292,845
TeladocCOM87918A105212,2801,673,999SH SOLE01,530,6150143,384
Telus CorpCOM87971M1039397SH DFND339700
Tenable HoldingsCOM88025T10215315SH DFND331500
Tencent Music Entertainment ADRSPONSORED ADS88034P10931,6934,371,428SH DFND14,371,42800
Tencent Music Entertainment ADRSPONSORED ADS88034P109274,16737,816,187SH DFND228,474,81809,341,369
Tencent Music Entertainment ADRSPONSORED ADS88034P10913,7211,892,505SH DFND3915,8650976,640
Tencent Music Entertainment ADRSPONSORED ADS88034P10948,8316,735,243SH SOLE05,887,6190847,624
TeradyneCOM88077010292,826850,290SH DFND1850,29000
TeradyneCOM880770102402,3033,685,106SH DFND23,487,9080197,198
TeradyneCOM88077010264,013586,363SH DFND3276,2190310,144
TeradyneCOM880770102231,6062,121,519SH SOLE01,853,2700268,249
Tesla IncCOM88160R1011,458,2321,880,425SH DFND11,880,42500
Tesla IncCOM88160R1016,046,9417,797,675SH DFND25,482,35402,315,321
Tesla IncCOM88160R101669,899863,851SH DFND3666,3160197,535
Tesla IncCOM88160R1012,567,7483,311,173SH SOLE02,860,3920450,781
Texas Roadhouse IncCOM88268110912131SH DFND313100
The Trade DeskCOM CL A88339J105824,46611,727,821SH DFND111,727,82100
The Trade DeskCOM CL A88339J1052,007,21028,552,064SH DFND219,562,47908,989,585
The Trade DeskCOM CL A88339J105221,0033,143,714SH DFND32,329,8790813,835
The Trade DeskCOM CL A88339J105608,7848,659,807SH SOLE06,477,75602,182,051
Thermo Fisher ScientificCOM883556102106,660186,688SH DFND1186,68800
Thermo Fisher ScientificCOM883556102403,056705,470SH DFND2661,910043,560
Thermo Fisher ScientificCOM88355610274,507130,409SH DFND361,554068,855
Thermo Fisher ScientificCOM883556102271,210474,699SH SOLE0415,368059,331
Thor Industries IncCOM88516010116133SH DFND313300
Toro CoCOM89109210824245SH DFND324500
Tractor Supply CoCOM89235610631151SH DFND315100
TransMedics GroupCOM89377M10927822SH DFND282200
TransMedics GroupCOM89377M10913400SH DFND340000
Trip.com Group Sponsored ADRAMERICAN DEP SHS89677Q107101,2953,294,152SH DFND22,584,9420709,210
TrupanionCOM89820210615,348197,600SH DFND1197,60000
TrupanionCOM89820210626,892346,239SH DFND2112,1180234,121
TrupanionCOM89820210611,088142,756SH DFND3142,75600
TrupanionCOM89820210657,087735,000SH SOLE0735,00000
TuSimple HdgsCL A90089L10813349SH DFND334900
Twilio IncCL A90138F102538,1241,686,644SH DFND11,686,64400
Twilio IncCL A90138F102953,1042,987,319SH DFND22,855,9580131,361
Twilio IncCL A90138F102107,355336,484SH DFND3211,1400125,344
Twilio IncCL A90138F102350,5451,098,714SH SOLE01,000,008098,706
UltragenyxCOM90400D10810115SH DFND311500
United Parcel ServiceCL B91131210647,184259,113SH DFND1259,11300
United Parcel ServiceCL B9113121061,0235,617SH DFND2005,617
United Parcel ServiceCL B9113121068504,666SH DFND34,66600
United Parcel ServiceCL B91131210647,350260,022SH SOLE0260,02200
UnitedHealthCOM91324P10239100SH DFND310000
Unity Biotechnology IncCOM91381U101744248,000SH DFND1248,00000
Unity Biotechnology IncCOM91381U1011,023341,111SH SOLE0341,11100
Upwork IncCOM91688F104111,0122,465,281SH DFND12,465,28100
Upwork IncCOM91688F10469,6291,546,272SH DFND2656,2860889,986
Upwork IncCOM91688F10435,175781,137SH DFND3706,489074,648
Upwork IncCOM91688F10454,6361,213,324SH SOLE01,213,32400
Uxin ADRADS91818X1083,3441,211,500SH DFND11,211,50000
Uxin ADRADS91818X1081,558564,600SH SOLE0564,60000
Vale SA ADRADR91912E10521,9071,570,361SH DFND11,570,36100
Vale SA ADRADR91912E105172,83512,389,609SH DFND26,564,03505,825,574
Vale SA ADRADR91912E1051,27291,158SH DFND391,15800
Varonis Systems IncCOM92228010232525SH DFND252500
Varonis Systems IncCOM92228010231517SH DFND351700
Vedanta Ltd ADRCOM92242Y10018,4281,206,000SH DFND11,206,00000
Vedanta Ltd ADRCOM92242Y10022,1171,447,435SH DFND21,447,43500
Vedanta Ltd ADRCOM92242Y1001,34087,716SH DFND387,71600
Vedanta Ltd ADRCOM92242Y10022,0281,441,655SH SOLE01,441,65500
Veeco InstrumentsCOM92241710013,034586,854SH DFND1586,85400
Veeco InstrumentsCOM92241710011,382512,454SH DFND2166,8740345,580
Veeco InstrumentsCOM9224171004,787215,536SH DFND3215,53600
Veeva Systems Inc Class ACOM9224751081,9166,648SH DFND16,64800
Veeva Systems Inc Class ACOM9224751084,26714,807SH DFND214,80700
Veeva Systems Inc Class ACOM9224751084,90417,016SH DFND317,01600
Veoneer IncCOM92336X10924700SH DFND370000
Verint Systems IncCOM92343X10018395SH DFND339500
Verisk AnalyticsCOM92345Y10610,11350,495SH DFND250,49500
VeritoneCOM92347M10014569SH DFND356900
ViewRayCOM92672L1077911SH DFND391100
Vimeo Inc.COM92719V10029,216994,740SH DFND1994,74000
Vimeo Inc.COM92719V100101,7403,464,092SH DFND23,090,8030373,289
Vimeo Inc.COM92719V10020,726705,688SH DFND3329,1540376,534
Vimeo Inc.COM92719V10076,6532,609,904SH SOLE02,285,1360324,768
Vir Biotechnology IncCOM92764N1021,25728,874SH DFND128,87400
Vir Biotechnology IncCOM92764N1022,66861,306SH DFND261,30600
Vir Biotechnology IncCOM92764N1023,17172,866SH DFND372,86600
Vir Biotechnology IncCOM92764N102162,6193,736,646SH SOLE03,736,64600
Visa Inc-Class A SharesCOM CL A92826C83911,67052,389SH DFND252,38900
Visa Inc-Class A SharesCOM CL A92826C83927121SH DFND312100
Visteon CorpCOM92839U20619200SH DFND320000
Vroom IncCOM92918V10993,2684,225,994SH DFND14,225,99400
Vroom IncCOM92918V109141,9236,430,576SH DFND26,220,9900209,586
Vroom IncCOM92918V1096,077275,341SH DFND3275,34100
Vroom IncCOM92918V10919,939903,446SH SOLE0903,44600
VuzixCOM92921W30010924SH DFND392400
Vyne Therapeutics IncCOM92941V2096848,706SH DFND148,70600
Vyne Therapeutics IncCOM92941V2097050,056SH SOLE050,05600
WD-40 CoCOM9292361071358SH DFND35800
WEC Energy GroupCOM92939U1061,34415,233SH DFND115,23300
Wal-Mart StoresCOM93114210314101SH DFND310100
Warby Parker IncCL A COM93403J10624,576463,257SH DFND2179,8010283,456
Warby Parker IncCL A COM93403J106240,1954,527,716SH SOLE04,527,71600
WatersCOM9418481039,02525,259SH DFND125,25900
WatersCOM94184810311,73532,843SH DFND232,84300
WatersCOM9418481034,05911,359SH DFND37,82003,539
WatersCOM941848103240672SH SOLE067200
Watsco IncCOM942622200211,367798,758SH DFND1798,75800
Watsco IncCOM942622200248,713939,889SH DFND2910,287029,602
Watsco IncCOM94262220016,81363,536SH DFND357,58005,956
Watsco IncCOM94262220063,502239,973SH SOLE0239,97300
Wayfair Inc Class ACL A94419L101714,3492,795,776SH DFND12,795,77600
Wayfair Inc Class ACL A94419L1011,103,9244,320,473SH DFND24,061,6050258,868
Wayfair Inc Class ACL A94419L101117,730460,766SH DFND3333,5170127,249
Wayfair Inc Class ACL A94419L101615,7612,409,929SH SOLE02,309,6390100,290
Wheaton Precious MetalsCOM96287910276720,416SH DFND120,41600
Williams-Sonoma IncCOM9699041011376SH DFND37600
Wix ComSHSM98068105651,7803,325,916SH DFND22,070,60301,255,313
Wix ComSHSM9806810580406SH DFND340600
Workday IncCL A98138H101378,3131,513,919SH DFND11,513,91900
Workday IncCL A98138H1011,393,2635,575,505SH DFND22,600,19202,975,313
Workday IncCL A98138H101154,672618,961SH DFND3522,368096,593
Workday IncCL A98138H101335,5691,342,865SH SOLE0727,0280615,837
XPELCOM98379L10022295SH DFND329500
Xencor IncCOM98401F10527828SH DFND282800
Xencor IncCOM98401F10514431SH DFND343100
Xperi Holding CorpCOM98390M103341,793SH DFND31,79300
XylemCOM98419M100119,870969,198SH DFND1969,19800
XylemCOM98419M10035,101283,801SH DFND2108,8400174,961
XylemCOM98419M100113,722919,489SH DFND3714,6750204,814
XylemCOM98419M10011,46292,673SH SOLE092,67300
Yatsen Holding Ltd ADRCOM9851941094,9491,298,849SH DFND11,298,84900
Yatsen Holding Ltd ADRCOM98519410941,33610,849,262SH DFND28,742,41002,106,852
Yatsen Holding Ltd ADRCOM98519410910026,280SH DFND326,28000
YelpCOM98581710510262SH DFND326200
Zai Lab ADRADR98887Q104148,5511,409,535SH DFND11,409,53500
Zai Lab ADRADR98887Q104271,0392,571,771SH DFND21,439,98901,131,782
Zai Lab ADRADR98887Q10458,499555,071SH DFND3243,4980311,573
Zai Lab ADRADR98887Q1046936,577SH DFND46,57700
Zai Lab ADRADR98887Q10437,132352,327SH SOLE0352,32700
Ziff Davis IncCOM48123V1021073SH DFND37300
Zillow Group Inc Class ACL A98954M101105,6901,193,155SH DFND11,193,15500
Zillow Group Inc Class ACL A98954M101174,6191,971,315SH DFND21,809,7820161,533
Zillow Group Inc Class ACL A98954M10112,747143,907SH DFND3143,90700
Zillow Group Inc Class ACL A98954M10129,111328,638SH SOLE0328,63800
Zillow Group Inc Class CCL C CAP STK98954M200150,7911,710,808SH DFND11,710,80800
Zillow Group Inc Class CCL C CAP STK98954M200304,6743,456,709SH DFND22,711,7090745,000
Zillow Group Inc Class CCL C CAP STK98954M20073,204830,543SH DFND3535,2010295,342
Zillow Group Inc Class CCL C CAP STK98954M200229,1142,599,435SH SOLE02,344,8220254,613
Zoom Video Communications IncCL A98980L101402,4251,538,909SH DFND11,538,90900
Zoom Video Communications IncCL A98980L1011,070,1904,092,503SH DFND22,364,63201,727,871
Zoom Video Communications IncCL A98980L101101,530388,260SH DFND3332,433055,827
Zoom Video Communications IncCL A98980L101507,1491,939,385SH SOLE01,588,2090351,176
Zuora Inc Class ACOM CL A98983V10629,4911,778,724SH DFND11,778,72400
Zuora Inc Class ACOM CL A98983V10615,942961,512SH DFND2312,2000649,312
Zuora Inc Class ACOM CL A98983V1066,671402,365SH DFND3402,36500
Zuora Inc Class ACOM CL A98983V10612,956781,436SH SOLE0781,43600
Zymergen IncCOM98985X10010,621806,451SH SOLE0806,45100
Zymergen Inc - converted at IPOCOM98985X10026,5442,015,505SH SOLE02,015,50500
ZynexCOM98986M1035437SH DFND343700
Zynga IncCOM98986T108222,863SH DFND32,86300
dLocalCL AG2901810130,211553,728SH DFND1553,72800
dLocalCL AG2901810113,437246,272SH DFND300246,272
iRobotCOM46272610016,382208,682SH DFND1208,68200
iRobotCOM4627261009,372119,385SH DFND3108,597010,788
iRobotCOM46272610023,248296,148SH SOLE0296,14800
iRobotCOM46272610018,976241,733SH DFND2100,5920141,141
iShares Physical Silver ETC (c)COM46428Q10955,8882,623,100SH DFND12,623,10000
iShares Physical Silver ETC (c)COM46428Q1093,496164,100SH DFND3164,10000
nCinoCOM63947U10716232SH DFND323200
nLIGHTCOM65487K10015542SH DFND354200