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Baillie Gifford & Co

Filed: 20 Jan 22, 10:33am

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X Genomics Inc Class ACL A COM88025U109305,6782,052,083SH DFND12,052,08300
10X Genomics Inc Class ACL A COM88025U109292,3911,962,880SH DFND21,824,9020137,978
10X Genomics Inc Class ACL A COM88025U109149,8221,005,789SH DFND3840,0080165,781
10X Genomics Inc Class ACL A COM88025U109276,7121,857,625SH SOLE01,857,62500
1Life HealthcareCOM68269G1078445SH DFND344500
2UCOM90214J1016319SH DFND331900
2seventy bioCOM9013841077286SH DFND328600
8x8 IncCOM282914100342,045SH DFND32,04500
908 DevicesCOM65443P1026249SH DFND324900
ACM ResearchCOM00108J10919220SH DFND322000
AJ Gallagher & CoCOM363576109183,8891,083,805SH DFND11,083,80500
AJ Gallagher & CoCOM363576109633,0933,731,319SH DFND23,455,4340275,885
AJ Gallagher & CoCOM363576109109,075642,865SH DFND3356,7770286,088
AJ Gallagher & CoCOM363576109451,8052,662,847SH SOLE01,746,6550916,192
Abcellera Biologics IncCOM00288U10622,2121,553,262SH DFND11,553,26200
Abcellera Biologics IncCOM00288U1066,055423,404SH DFND2165,6550257,749
Abcellera Biologics IncCOM00288U10620,8651,459,075SH DFND31,147,1890311,886
Abcellera Biologics IncCOM00288U1061,976138,167SH SOLE0138,16700
AbiomedCOM003654100413,9961,152,646SH DFND11,152,64600
AbiomedCOM003654100568,9121,583,962SH DFND21,469,7490114,213
AbiomedCOM003654100184,822514,582SH DFND3396,3890118,193
AbiomedCOM003654100211,476588,790SH SOLE0434,6040154,186
Acadia Pharmaceuticals IncCOM00422510813544SH DFND354400
Accelerate DiagnosticsCOM00430H1022418SH DFND341800
Accenture 'A'COMG1151C1012048SH DFND34800
Acutus MedicalCOM0051111091424SH DFND342400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10719,3765,166,864SH DFND15,166,86400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10713,9093,709,166SH DFND21,286,10602,423,060
Adaptimmune Therapeutics ADRSPONDS ADR00653A1075,9981,599,343SH DFND31,599,34300
Adaptimmune Therapeutics ADRSPONDS ADR00653A10712,3043,280,979SH SOLE03,280,97900
Adicet Bio IncCOM0070021081,63493,449SH DFND193,44900
Adicet Bio IncCOM0070021081,54288,177SH SOLE088,17700
Advanced Micro Devices IncCOM00790310759407SH DFND340700
AerovironmentCOM00807310821,743350,517SH DFND1350,51700
AerovironmentCOM00807310815,231245,537SH DFND285,7930159,744
AerovironmentCOM0080731087,062113,841SH DFND3113,84100
AerovironmentCOM00807310813,682220,567SH SOLE0220,56700
Affirm Holdings Inc Class ACOM CL A00827B106256,1042,546,783SH DFND12,546,78300
Affirm Holdings Inc Class ACOM CL A00827B106647,0856,434,816SH DFND23,976,36402,458,452
Affirm Holdings Inc Class ACOM CL A00827B10667,948675,693SH DFND3584,606091,087
Affirm Holdings Inc Class ACOM CL A00827B106419,6014,172,646SH SOLE03,630,8830541,763
Affirm Holdings Inc Class B - converted at IPOCOM CL A00827B106249,8492,484,575SH SOLE02,484,57500
Agios Pharmaceuticals IncCOM00847X1046186SH DFND318600
Agora Inc ADRADS00851L1037,931489,288SH DFND1489,28800
Agora Inc ADRADS00851L1034,134255,012SH SOLE0255,01200
Albemarle CorpCOM012653101161,900692,561SH DFND1692,56100
Albemarle CorpCOM012653101490,3232,097,459SH DFND21,935,3710162,088
Albemarle CorpCOM01265310178,161334,351SH DFND3222,4870111,864
Albemarle CorpCOM012653101309,5671,324,238SH SOLE01,042,0270282,211
Alector IncCOM0144421071,29062,477SH DFND162,47700
Alector IncCOM0144421072,715131,492SH DFND2131,49200
Alector IncCOM0144421073,423165,755SH DFND3165,75500
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102117,119985,936SH DFND1985,93600
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102401,6623,381,277SH DFND22,823,2390558,038
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W10246,109388,154SH DFND3126,6810261,473
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102133,6591,125,171SH SOLE0777,1710348,000
Align Technology IncCOM01625510116,18724,631SH DFND224,63100
Alkermes PlcCOMG017671054192SH DFND319200
Allbirds IncCOM CL A01675A1098,030532,500SH SOLE0532,50000
Allscripts Healthcare SolutionCOM01988P10814744SH DFND374400
Alnylam PharmaceuticalsCOM02043Q107484,9492,859,708SH DFND12,859,70800
Alnylam PharmaceuticalsCOM02043Q107709,3954,183,249SH DFND23,530,3890652,860
Alnylam PharmaceuticalsCOM02043Q107239,4341,411,926SH DFND31,112,5080299,418
Alnylam PharmaceuticalsCOM02043Q107366,6102,161,868SH SOLE01,617,1650544,703
Alphabet Inc Class ACAP STK CL A02079K3056,6982,312SH DFND12,31200
Alphabet Inc Class ACAP STK CL A02079K30535,60212,289SH DFND212,0160273
Alphabet Inc Class ACAP STK CL A02079K3053,1691,094SH DFND37150379
Alphabet Inc Class ACAP STK CL A02079K305107,33537,050SH SOLE037,05000
Alphabet Inc Class CCAP STK CL C02079K107252,48087,255SH DFND187,25500
Alphabet Inc Class CCAP STK CL C02079K107976,966337,631SH DFND2313,003024,628
Alphabet Inc Class CCAP STK CL C02079K107161,13555,687SH DFND329,986025,701
Alphabet Inc Class CCAP STK CL C02079K107560,946193,858SH SOLE0111,772082,086
Alteryx IncCOM02156B10320336SH DFND333600
Amazon.ComCOM023135106969,523290,769SH DFND1290,76900
Amazon.ComCOM0231351063,646,8581,093,727SH DFND2624,8710468,856
Amazon.ComCOM023135106450,203135,020SH DFND3104,111030,909
Amazon.ComCOM0231351061,909,847572,781SH SOLE0418,7710154,010
AmbarellaSHSG037AX10154,943270,800SH DFND1270,80000
AmbarellaSHSG037AX10127,163133,882SH DFND245,883087,999
AmbarellaSHSG037AX10113,56566,857SH DFND366,85700
AmbarellaSHSG037AX10119,80397,605SH SOLE097,60500
AmdocsCOMG0260210327365SH DFND336500
AmerenCOM0236081021,06411,959SH DFND111,95900
American Superconductor CorpCOM0301112077,870723,370SH DFND1723,37000
American Superconductor CorpCOM0301112078,356768,000SH SOLE0768,00000
American Tower Corp REITCOM03027X1006822,330SH DFND12,33000
American Well Corp Class ACOM03044L10558596,791SH DFND196,79100
American Well Corp Class ACOM03044L1051,187196,523SH DFND2196,52300
American Well Corp Class ACOM03044L1051,969325,964SH DFND3325,96400
Amicus Therapeutics IncCOM03152W1096538SH DFND353800
Amkor TechnologyCOM031652100441,765SH DFND31,76500
Amneal Pharmaceuticals IncCOM03168L1052452SH DFND345200
Analog DevicesCOM03265410531,770180,748SH DFND1180,74800
Analog DevicesCOM0326541055903,356SH DFND2003,356
Analog DevicesCOM0326541056,63937,772SH DFND337,77200
Analog DevicesCOM03265410530,518173,622SH SOLE0173,62200
Anaplan Inc CommonCOM03272L10814306SH DFND330600
AnterixCOM03676C10010162SH DFND316200
Anthem IncCOM036752103264,343570,271SH DFND1570,27100
Anthem IncCOM036752103988,3342,132,143SH DFND21,971,5790160,564
Anthem IncCOM036752103169,739366,179SH DFND3200,3680165,811
Anthem IncCOM036752103701,6691,513,719SH SOLE0976,2420537,477
AppFolioCOM03783C10026212SH DFND321200
Appian CorpCL A03782L101144,4972,215,876SH DFND12,215,87600
Appian CorpCL A03782L101179,3022,749,611SH DFND22,414,3490335,262
Appian CorpCL A03782L10120,747318,164SH DFND3318,16400
Appian CorpCL A03782L10157,727885,245SH SOLE0885,24500
AppleCOM03783310038,602217,392SH DFND1217,39200
AppleCOM0378331007124,012SH DFND2004,012
AppleCOM0378331007,98044,939SH DFND344,93900
AppleCOM03783310036,591206,067SH SOLE0206,06700
AptivCOMG6095L10922134SH DFND313400
Ares Capital CorpCOM04010L10388,6594,184,000SH DFND14,184,00000
Ares Capital CorpCOM04010L10322710,700SH DFND210,70000
Ares Capital CorpCOM04010L1036,151290,270SH DFND3290,27000
ArganCOM04010E1094103SH DFND310300
Ascendis Pharma ADR 1:1SPON ADR04351P1011,97914,709SH DFND114,70900
Ascendis Pharma ADR 1:1SPON ADR04351P1014,27531,777SH DFND231,77700
Ascendis Pharma ADR 1:1SPON ADR04351P1015,32639,586SH DFND339,58600
Asensus Surgical IncCOM04367G10365,338SH DFND35,33800
AstraZeneca ADRCOM04635310823400SH DFND340000
Atlassian Corp PlcCL AG06242104187,736492,371SH DFND1492,37100
Atlassian Corp PlcCL AG062421041,408,0013,692,729SH DFND21,225,50402,467,225
Atlassian Corp PlcCL AG06242104179,831471,639SH DFND3397,377074,262
Atlassian Corp PlcCL AG06242104393,4271,031,831SH SOLE0478,2140553,617
AtrionCOM04990410569SH DFND3900
Aurora Innovation Class A CommonCOM CL A051774107168,90015,000,000SH SOLE015,000,00000
AvangridCOM05351W103128,3942,574,064SH DFND12,574,06400
AvangridCOM05351W1033166,328SH DFND26,32800
AvangridCOM05351W1037,907158,525SH DFND3158,52500
Avery Dennison CorporationCOM05361110922100SH DFND310000
Axogen IncCOM05463X10685491,124SH DFND191,12400
Axogen IncCOM05463X10677282,358SH DFND229,622052,736
Axogen IncCOM05463X10640142,820SH DFND342,82000
Axogen IncCOM05463X10632935,133SH SOLE035,13300
Axon Enterprise IncCOM05464C101130,414830,665SH DFND1830,66500
Axon Enterprise IncCOM05464C101304,6511,940,453SH DFND21,659,2790281,174
Axon Enterprise IncCOM05464C10164,939413,623SH DFND3276,5060137,117
Axon Enterprise IncCOM05464C101221,9911,413,954SH SOLE0953,5690460,385
Axonics Modulation TechnologiesCOM05465P10111198SH DFND319800
Baidu.com Sponsored ADRSPON ADR REP A0567521088,55457,489SH DFND157,48900
Baidu.com Sponsored ADRSPON ADR REP A056752108517,9083,480,798SH DFND23,169,9810310,817
Baidu.com Sponsored ADRSPON ADR REP A05675210827,271183,288SH DFND321,3080161,980
Baidu.com Sponsored ADRSPON ADR REP A0567521081,0587,113SH DFND47,11300
Banco Bradesco Pn ADRSP ADR PFD NEW05946030315,6244,568,526SH DFND14,568,52600
Banco Bradesco Pn ADRSP ADR PFD NEW059460303117,19034,266,085SH DFND218,874,357015,391,728
Banco Bradesco Pn ADRSP ADR PFD NEW0594603035,3031,550,515SH DFND31,550,51500
BandwidthCOM05988J10321287SH DFND228700
BandwidthCOM05988J1037109,892SH DFND39,89200
Baozun Spn Adr 1:1SPONSORED ADR06684L1038,234592,408SH DFND1592,40800
Baozun Spn Adr 1:1SPONSORED ADR06684L1036,192445,479SH DFND2155,2840290,195
Baozun Spn Adr 1:1SPONSORED ADR06684L1032,682192,945SH DFND3192,94500
Baozun Spn Adr 1:1SPONSORED ADR06684L1034,088294,100SH SOLE0294,10000
Beam TherapeuticsCOM07373V10532398SH DFND339800
Beam TherapeuticsCOM07373V10581910,275SH SOLE010,27500
BeiGene LtdSPONSORED ADR07725L102103,290381,241SH DFND1381,24100
BeiGene LtdSPONSORED ADR07725L102770,7602,844,868SH DFND21,119,60901,725,259
BeiGene LtdSPONSORED ADR07725L10275,891280,112SH DFND3235,497044,615
BeiGene LtdSPONSORED ADR07725L102167,348617,678SH SOLE0286,2070331,471
Benefitfocus IncCOM08180D1063,267306,448SH DFND1306,44800
Benefitfocus IncCOM08180D1063,343313,569SH DFND2105,8880207,681
Benefitfocus IncCOM08180D1061,778166,790SH DFND3166,79000
Benefitfocus IncCOM08180D1062,413226,368SH SOLE0226,36800
Berkeley Lights IncCOM08431010123,7981,309,003SH DFND11,309,00300
Berkeley Lights IncCOM0843101019,371515,466SH DFND2367,2000148,266
Berkeley Lights IncCOM08431010121,4041,177,327SH DFND31,000,1520177,175
Berkeley Lights IncCOM0843101015,939326,690SH SOLE0326,69000
Beyond Meat IncCOM08862E10983,0181,274,067SH DFND11,274,06700
Beyond Meat IncCOM08862E109304,3114,670,215SH DFND21,554,90203,115,313
Beyond Meat IncCOM08862E10979,2471,216,195SH DFND3991,2860224,909
Beyond Meat IncCOM08862E10985,4251,311,005SH SOLE0637,8160673,189
Bilibili Inc ADRSPONSORED ADR0900401066,491139,895SH DFND200139,895
Bilibili Inc ADRSPONSORED ADR0900401061,20926,051SH DFND30026,051
Bilibili Inc ADRSPONSORED ADR0900401062,63956,879SH SOLE00056,879
BioCryst PharmaceuticalsCOM09058V103211,500SH DFND31,50000
BioNTech ADRSPONS ADS09075V102138,799538,399SH DFND1538,39900
BioNTech ADRSPONS ADS09075V1021,129,3424,380,690SH DFND21,616,57202,764,118
BioNTech ADRSPONS ADS09075V102126,995492,611SH DFND3431,832060,779
BioNTech ADRSPONS ADS09075V102288,9261,120,736SH SOLE0519,6790601,057
Biomarin Pharmaceutical IncCOM09061G101782SH DFND38200
BlacklineCOM09239B10962,843606,942SH DFND1606,94200
BlacklineCOM09239B10935,415342,041SH DFND2119,4670222,574
BlacklineCOM09239B10916,239156,837SH DFND3156,83700
BlacklineCOM09239B10929,051280,576SH SOLE0280,57600
Blackrock IncCOM09247X1011921SH DFND32100
Blink ChargingCOM09354A10011400SH DFND340000
Blue Apron Holdings IncCL A09523Q101999148,506SH DFND1148,50600
Bluebird Bio IncCOM09609G1009860SH DFND386000
Blueprint Medicines CorpCOM09627Y10934315SH DFND331500
Booking Holdings IncCOM09857L108117,78849,094SH DFND149,09400
Booking Holdings IncCOM09857L108370,595154,464SH DFND2142,448012,016
Booking Holdings IncCOM09857L10865,82527,436SH DFND315,031012,405
Booking Holdings IncCOM09857L108271,595113,201SH SOLE072,460040,741
Boston OmahaCOM10104410515529SH DFND352900
Box IncCOM10316T10426979SH DFND397900
Brady CorpCOM10467410611200SH DFND320000
BridgeBio Pharma IncCOM10806X1021,39083,339SH DFND183,33900
BridgeBio Pharma IncCOM10806X1023,090185,242SH DFND2185,24200
BridgeBio Pharma IncCOM10806X1023,689221,140SH DFND3221,14000
Bristol Myers SquibbCOM11012210827427SH DFND342700
Broadridge Finl.Sltn.COM11133T10393,335510,527SH DFND1510,52700
Broadridge Finl.Sltn.COM11133T103360,8241,973,656SH DFND21,832,6510141,005
Broadridge Finl.Sltn.COM11133T10359,359324,687SH DFND3176,6930147,994
Broadridge Finl.Sltn.COM11133T103243,3041,330,837SH SOLE0851,4880479,349
Brookfield RenewableCOM11284V10575,4752,049,284SH DFND12,049,28400
Brookfield RenewableCOM11284V1051574,252SH DFND24,25200
Brookfield RenewableCOM11284V1053,905106,015SH DFND3106,01500
Bumble IncCOM CL A12047B10513,544400,000SH SOLE0400,00000
Burford CapitalORD SHSG179771105,215499,402SH DFND2499,40200
Burford CapitalORD SHSG1797711011,6851,118,922SH DFND11,118,92200
Burning Rock Biotech Ltd ADRSPON ADS12233L10721,5372,259,910SH DFND12,259,91000
Burning Rock Biotech Ltd ADRSPON ADS12233L10759,9606,291,678SH DFND24,066,02902,225,649
Burning Rock Biotech Ltd ADRSPON ADS12233L1072,069217,143SH DFND339,4310177,712
Burning Rock Biotech Ltd ADRSPON ADS12233L1071,256131,772SH SOLE0131,77200
Butterfly Network IncCOM CL A1241551021,607240,283SH DFND1240,28300
Butterfly Network IncCOM CL A1241551022,512375,532SH DFND2375,53200
Butterfly Network IncCOM CL A1241551024,319645,573SH DFND3645,57300
Butterfly Network IncCOM CL A1241551025,433812,150SH SOLE0812,15000
C3.aiCL A12468P1044117SH DFND311700
CEVA IncCOM1572101057,726178,680SH DFND1178,68000
CEVA IncCOM1572101056,888159,286SH DFND253,7650105,521
CEVA IncCOM1572101053,26775,552SH DFND375,55200
CEVA IncCOM1572101053,56782,500SH SOLE082,50000
CH Robinson WorldwideCOM NEW12541W20933,268309,092SH DFND1309,09200
CH Robinson WorldwideCOM NEW12541W2096105,663SH DFND2005,663
CH Robinson WorldwideCOM NEW12541W2096,70062,249SH DFND362,24900
CH Robinson WorldwideCOM NEW12541W20929,799276,867SH SOLE0276,86700
CS Disco IncCOM12632710518504SH DFND250400
CS Disco IncCOM12632710560416,907SH DFND316,90700
Calavo Growers IncCOM1282461055113SH DFND311300
Cardlytics IncCOM14161W10519,260291,424SH DFND1291,42400
Cardlytics IncCOM14161W10519,127289,409SH DFND2100,4850188,924
Cardlytics IncCOM14161W1058,705131,719SH DFND3131,71900
Cardlytics IncCOM14161W10513,570205,324SH SOLE0205,32400
Cargurus IncCOM14178810926759SH DFND275900
Cargurus IncCOM14178810987626,055SH DFND326,05500
CarvanaCOM146869102339,1401,463,136SH DFND11,463,13600
CarvanaCOM1468691021,184,0305,108,202SH DFND22,904,54102,203,661
CarvanaCOM146869102136,581589,243SH DFND3468,9250120,318
CarvanaCOM146869102578,3802,495,274SH SOLE01,840,5980654,676
Castle BiosciencesCOM14843C10510225SH DFND322500
Cbre Group IncCL A12504L109172,5411,590,094SH DFND11,590,09400
Cbre Group IncCL A12504L109554,8345,113,204SH DFND24,734,0730379,131
Cbre Group IncCL A12504L10994,064866,872SH DFND3477,6150389,257
Cbre Group IncCL A12504L109387,2203,568,522SH SOLE02,306,43701,262,085
Cellectis ADRSPONS ADS15117K1035,900726,605SH DFND1726,60500
Cellectis ADRSPONS ADS15117K1031,400172,406SH DFND2172,40600
Cellectis ADRSPONS ADS15117K1031,466180,500SH SOLE0180,50000
Celsius HoldingsCOM15118V20719260SH DFND326000
Cemex ADRSPON ADR NEW15129088936,0995,324,348SH DFND15,324,34800
Cemex ADRSPON ADR NEW151290889196,92929,045,627SH DFND211,115,564017,930,063
Cemex ADRSPON ADR NEW15129088958,2138,586,018SH DFND31,166,62507,419,393
Cemex ADRSPON ADR NEW1512908892,400353,925SH DFND4353,92500
CertaraCOM15687V10943,5961,533,993SH DFND11,533,99300
CertaraCOM15687V109161,1495,670,256SH DFND25,006,0560664,200
CertaraCOM15687V10928,364998,037SH DFND3540,6910457,346
CertaraCOM15687V109123,4224,342,782SH SOLE02,810,93601,531,846
CerusCOM15708510181,143SH DFND31,14300
ChargePoint Holdings IncCOM CL A15961R1051226,415SH DFND16,41500
ChargePoint Holdings IncCOM CL A15961R10587,1524,574,933SH SOLE04,574,93300
Charles SchwabCOM80851310580,338955,271SH DFND1955,27100
Charles SchwabCOM808513105289,0583,437,071SH DFND23,172,9000264,171
Charles SchwabCOM80851310550,394599,210SH DFND3331,2440267,966
Charles SchwabCOM808513105211,4882,514,716SH SOLE01,608,8030905,913
CheggCOM163092109181,7895,921,472SH DFND15,921,47200
CheggCOM163092109261,3788,513,946SH DFND27,595,5750918,371
CheggCOM16309210940,4931,319,002SH DFND31,058,1700260,832
CheggCOM16309210999,9163,254,587SH SOLE02,614,7960639,791
Chewy IncCL A16679L109212,2993,600,112SH DFND13,600,11200
Chewy IncCL A16679L109390,4946,621,912SH DFND26,380,0130241,899
Chewy IncCL A16679L10939,146663,835SH DFND3463,8470199,988
Chewy IncCL A16679L109142,5192,416,808SH SOLE01,771,3640645,444
Chinook TherapeuticsCOM16961L1066,462396,187SH DFND1396,18700
Chinook TherapeuticsCOM16961L1063,739229,272SH DFND283,2090146,063
Chinook TherapeuticsCOM16961L1061,652101,295SH DFND3101,29500
Chinook TherapeuticsCOM16961L1061,909117,058SH SOLE0117,05800
Church & Dwight Co IncCOM17134010218179SH DFND317900
Cisco SystemsCOM17275R10222,585356,400SH DFND1356,40000
Cisco SystemsCOM17275R1024106,472SH DFND2006,472
Cisco SystemsCOM17275R1024,68673,949SH DFND373,94900
Cisco SystemsCOM17275R10220,904329,865SH SOLE0329,86500
Clear Secure IncCOM18467V10931,3701,000,000SH SOLE01,000,00000
Cloudflare IncCL A COM18915M107612,7434,659,643SH DFND14,659,64300
Cloudflare IncCL A COM18915M1072,123,16916,145,772SH DFND29,760,10006,385,672
Cloudflare IncCL A COM18915M107246,7691,876,569SH DFND31,500,3450376,224
Cloudflare IncCL A COM18915M107748,3645,690,979SH SOLE03,399,70102,291,278
Clover Health Investments CorpCOM CL A18914F10328,9707,787,680SH SOLE07,787,68000
CoStar GroupCOM22160N109288,7173,653,262SH DFND13,653,26200
CoStar GroupCOM22160N109557,3427,052,279SH DFND26,779,0410273,238
CoStar GroupCOM22160N10957,928732,992SH DFND3498,5480234,444
CoStar GroupCOM22160N109217,6542,754,064SH SOLE01,999,4430754,621
Coca ColaCOM19121610021,737367,123SH DFND1367,12300
Coca ColaCOM1912161005579,414SH DFND2009,414
Coca ColaCOM19121610090015,207SH DFND315,20700
Coca ColaCOM19121610028,415479,900SH SOLE0479,90000
CodexisCOM19200510679,9402,556,457SH DFND12,556,45700
CodexisCOM19200510668,7512,198,633SH DFND2894,78201,303,851
CodexisCOM19200510633,5251,072,127SH DFND3994,322077,805
CodexisCOM19200510642,3771,355,185SH SOLE01,355,18500
Cognyte SoftwareORD SHSM251331056369SH DFND336900
Cohen & Steers IncCOM19247A10028301SH DFND330100
Coherus BioSciencesCOM19249H103231,431SH DFND31,43100
CohuCOM19257610627700SH DFND370000
Columbia Sportswear CoCOM198516106995SH DFND39500
Commscope Holding Co IncCOM20337X109161,442SH DFND31,44200
Consensus Cloud SolutionsCOM20848V105124SH DFND32400
Consolidated EdisonCOM209115104137,2591,608,754SH DFND11,608,75400
Consolidated EdisonCOM2091151043534,135SH DFND24,13500
Consolidated EdisonCOM2091151048,758102,646SH DFND3102,64600
Cooper Cos Inc/TheCOM21664840213,14331,373SH DFND231,37300
Copa Holdings S ACL AP3107610534,206413,810SH DFND1413,81000
Copa Holdings S ACL AP31076105292,9563,544,108SH DFND22,294,91101,249,197
Copa Holdings S ACL AP3107610562,367754,506SH DFND394,3080660,198
Copa Holdings S ACL AP310761052,32428,117SH DFND428,11700
CorningCOM21935010524653SH DFND365300
Costco Wholesale CorporationCOM22160K1053359SH DFND35900
Coupa Software IncCOM22266L10649309SH DFND330900
CoupangCL A22266T109173,6625,910,897SH DFND15,910,89700
CoupangCL A22266T1091,231,41041,913,213SH DFND221,472,127020,441,086
CoupangCL A22266T109144,0864,904,216SH DFND33,509,85801,394,358
CoupangCL A22266T10954518,547SH DFND418,54700
CoupangCL A22266T109348,69211,868,349SH SOLE06,299,09905,569,250
Coursera IncCOM22266M104164,8316,744,332SH DFND16,744,33200
Coursera IncCOM22266M104160,8386,580,949SH DFND26,084,4320496,517
Coursera IncCOM22266M10466,7152,729,728SH DFND32,230,6160499,112
Coursera IncCOM22266M10429,4651,205,588SH SOLE01,205,58800
CredicorpCOMG2519Y10811,34892,965SH DFND192,96500
CredicorpCOMG2519Y10831,087254,667SH DFND221,1650233,502
CredicorpCOMG2519Y10834,253280,599SH DFND334,8800245,719
CredicorpCOMG2519Y1081,48412,158SH DFND412,15800
CrowdStrike HoldingsCOM22788C10523114SH DFND311400
Cullen/Frost BankersCOM22989910915,843125,667SH DFND1125,66700
Cullen/Frost BankersCOM2298991092962,347SH DFND2002,347
Cullen/Frost BankersCOM2298991093,34626,541SH DFND326,54100
Cullen/Frost BankersCOM22989910914,918118,329SH SOLE0118,32900
Curevac N.V.COMN2451R105134,6103,923,340SH DFND23,479,9510443,389
CyberArk Software LtdSHSM2682V10844,026254,077SH DFND1254,07700
CyberArk Software LtdSHSM2682V10837,741217,803SH DFND275,9080141,895
CyberArk Software LtdSHSM2682V10817,634101,765SH DFND3101,76500
CyberArk Software LtdSHSM2682V10819,948115,118SH SOLE0115,11800
Dada Nexus Ltd ADRADS23344D10844,1323,353,506SH DFND13,353,50600
Dada Nexus Ltd ADRADS23344D10849,8513,788,081SH DFND22,553,97501,234,106
Dada Nexus Ltd ADRADS23344D10872354,962SH DFND354,96200
Dada Nexus Ltd ADRADS23344D10810,300782,705SH SOLE0782,70500
Darden RestaurantsCOM2371941051282SH DFND38200
DatadogCOM23804L103284,5331,597,512SH DFND11,597,51200
DatadogCOM23804L103584,7493,283,080SH DFND23,140,2800142,800
DatadogCOM23804L10365,521367,868SH DFND3239,6200128,248
DatadogCOM23804L103253,1551,421,338SH SOLE01,005,9960415,342
Deere & CoCOM244199105161,267470,316SH DFND1470,31600
Deere & CoCOM24419910544,628130,152SH DFND250,946079,206
Deere & CoCOM244199105161,074469,754SH DFND3374,043095,711
Deere & CoCOM24419910514,04840,968SH SOLE040,96800
Denali TherapeuticsCOM24823R105136,9973,071,691SH DFND13,071,69100
Denali TherapeuticsCOM24823R105188,7264,231,514SH DFND24,149,752081,762
Denali TherapeuticsCOM24823R10521,674485,954SH DFND3447,334038,620
Denali TherapeuticsCOM24823R105324,1187,267,222SH SOLE07,267,22200
DermTechCOM24984K1055286SH DFND328600
Dexcom IncCOM252131107393,216732,314SH DFND1732,31400
Dexcom IncCOM2521311071,274,8542,374,251SH DFND2807,85501,566,396
Dexcom IncCOM252131107394,779735,224SH DFND3602,8460132,378
Dexcom IncCOM252131107358,359667,397SH SOLE0329,1650338,232
DigimarcCOM25381B10110,361262,445SH DFND1262,44500
DigimarcCOM25381B10111,823299,472SH DFND2104,5990194,873
DigimarcCOM25381B1015,652143,163SH DFND3143,16300
DigimarcCOM25381B1016,108154,711SH SOLE0154,71100
Digital Realty Trust REITCOM2538681033511,986SH DFND11,98600
DoceboCOM25609L1059,368139,426SH DFND2139,42600
DoceboCOM25609L10518267SH DFND326700
Dolby Laboratories 'A'COM25659T10715,566163,477SH DFND1163,47700
Dolby Laboratories 'A'COM25659T1072863,008SH DFND2003,008
Dolby Laboratories 'A'COM25659T1073,21533,764SH DFND333,76400
Dolby Laboratories 'A'COM25659T10714,800155,427SH SOLE0155,42700
DomoCOM25755410516321SH DFND332100
DonaldsonCOM25765110926436SH DFND343600
Doordash IncCOM25809K105198,7671,334,903SH DFND11,334,90300
Doordash IncCOM25809K105462,7903,108,058SH DFND22,943,0940164,964
Doordash IncCOM25809K10560,204404,323SH DFND3246,3000158,023
Doordash IncCOM25809K105378,5232,542,132SH SOLE02,030,8840511,248
DropboxCL A26210C10422881SH DFND388100
Duck Creek TechnologiesSHS26412010611355SH DFND335500
Duke Realty Corporation REITCOM26441150587,0481,326,150SH DFND11,326,15000
Duke Realty Corporation REITCOM2644115052233,392SH DFND23,39200
Duke Realty Corporation REITCOM2644115053,93759,980SH DFND359,98000
Duolingo IncCL A COM26603R10685,529806,040SH DFND1806,04000
Duolingo IncCL A COM26603R10678,707741,748SH DFND2674,644067,104
Duolingo IncCL A COM26603R10640,274379,552SH DFND3311,632067,920
Duolingo IncCL A COM26603R10614,691138,448SH SOLE0138,44800
EHang Hdgs ADRADS26853E102432,855SH DFND12,85500
EargoCOM2700871091263SH DFND326300
EcolabCOM27886510094,888404,486SH DFND1404,48600
EcolabCOM27886510037,701160,709SH DFND293,163067,546
EcolabCOM27886510093,147397,064SH DFND3315,333081,731
EcolabCOM2788651007,52232,065SH SOLE032,06500
Edwards Lifesciences CorpCOM28176E1086,82252,660SH DFND152,66000
Edwards Lifesciences CorpCOM28176E10831,427242,589SH DFND2242,58900
Edwards Lifesciences CorpCOM28176E10817,805137,439SH DFND3137,43900
Electronic Arts, Inc.COM28551210922164SH DFND316400
Emergent Biosolutions IncCOM29089Q10517385SH DFND338500
Enphase Energy IncCOM29355A107175954SH DFND195400
Estee Lauder 'A'COM518439104136,365368,356SH DFND1368,35600
Estee Lauder 'A'COM518439104549,8841,485,370SH DFND21,381,4410103,929
Estee Lauder 'A'COM51843910486,891234,713SH DFND3127,4490107,264
Estee Lauder 'A'COM518439104361,482976,451SH SOLE0628,6990347,752
EverQuote IncCOM CL A30041R10811,259718,967SH DFND1718,96700
EverQuote IncCOM CL A30041R1084,431282,932SH DFND297,8100185,122
EverQuote IncCOM CL A30041R1082,594165,649SH DFND3165,64900
EverQuote IncCOM CL A30041R1083,626231,550SH SOLE0231,55000
Everbridge IncCOM29978A10422,272330,786SH DFND1330,78600
Everbridge IncCOM29978A10414,552216,129SH DFND275,2530140,876
Everbridge IncCOM29978A1046,872102,066SH DFND3102,06600
Everbridge IncCOM29978A1049,995148,446SH SOLE0148,44600
Eversource EnergyCOM30040W108146,8221,613,782SH DFND11,613,78200
Eversource EnergyCOM30040W1083123,428SH DFND23,42800
Eversource EnergyCOM30040W1087,77285,428SH DFND385,42800
Exact SciencesCOM30063P10584,8561,090,280SH DFND11,090,28000
Exact SciencesCOM30063P105136,8111,757,823SH DFND21,409,1850348,638
Exact SciencesCOM30063P10538,069489,136SH DFND3372,5680116,568
Exact SciencesCOM30063P10593,9221,206,755SH SOLE0864,2710342,484
ExelixisCOM30161Q104221,200SH DFND31,20000
Exelon CorporationCOM30161N1011,51926,295SH DFND126,29500
Expedia Group IncCOM30212P30330165SH DFND316500
Expeditors IntlCOM30213010917126SH DFND312600
Expensify IncCOM CL A30219Q10622,693515,760SH DFND1515,76000
Expensify IncCOM CL A30219Q10632722SH DFND272200
Expensify IncCOM CL A30219Q1061,07224,374SH DFND324,37400
Expensify IncCOM CL A30219Q10615,802359,144SH SOLE0359,14400
ExponentCOM30214U10228242SH DFND324200
Exscientia Ltd ADRADS30223G10218,065914,241SH DFND1914,24100
Exscientia Ltd ADRADS30223G10231,6291,600,646SH DFND2210,05601,390,590
Exscientia Ltd ADRADS30223G1024,062205,560SH DFND3205,56000
Exscientia Ltd ADRADS30223G10226,1751,324,645SH SOLE0767,3390557,306
Factset Research SystemsCOM3030751053061SH DFND36100
FarfetchORD SHS CL A30744W107113,1533,384,773SH DFND13,384,77300
FarfetchORD SHS CL A30744W107538,40516,105,441SH DFND213,628,44902,476,992
FarfetchORD SHS CL A30744W10762,2041,860,733SH DFND31,091,7410768,992
FarfetchORD SHS CL A30744W107302,5309,049,649SH SOLE05,818,66803,230,981
FastenalCOM31190010467,0601,046,836SH DFND11,046,83600
FastenalCOM31190010419,020296,909SH DFND2259,555037,354
FastenalCOM31190010416,800262,250SH DFND3233,974028,276
FastenalCOM31190010452,339817,025SH SOLE0817,02500
FastlyCL A31188V1007205SH DFND320500
Ferrari NVCOMN3167Y1032,226,9658,607,858SH DFND27,016,91101,590,947
Ferrari NVCOMN3167Y103351,8291,359,921SH SOLE01,359,92100
Fibrogen IncCOM31572Q8087467SH DFND346700
First Industrial REITCOM32054K10379,1931,196,270SH DFND11,196,27000
First Industrial REITCOM32054K1032023,053SH DFND23,05300
First Industrial REITCOM32054K1033,57954,063SH DFND354,06300
First Majestic SilverCOM32076V103908,100SH DFND28,10000
First Republic BankCOM33616C100342,9061,660,481SH DFND11,660,48100
First Republic BankCOM33616C100494,0462,392,359SH DFND22,352,404039,955
First Republic BankCOM33616C10036,421176,362SH DFND3158,568017,794
First Republic BankCOM33616C10068,954333,900SH SOLE0333,90000
FirstCash Holdings IncCOM33767D10514,594195,084SH DFND1195,08400
FirstCash Holdings IncCOM33767D10585811,467SH DFND311,46700
Fiverr IntlORD SHSM4R82T106761SH DFND36100
FortisCOM3495531071,51431,332SH DFND131,33200
Fortive CorpCOM34959J1087,46297,814SH DFND297,81400
FoxCOM35137L10513359SH DFND335900
Freshpet IncCOM35803910519196SH DFND219600
Freshpet IncCOM3580391056326,634SH DFND36,63400
Full Truck Alliance - converted at IPOSPONS ADS35969L10808SH SOLE0800
Full Truck Alliance Co Ltd ADRSPONS ADS35969L108134,56916,077,530SH DFND215,900,2440177,286
Full Truck Alliance Co Ltd ADRSPONS ADS35969L10852,3886,259,050SH SOLE06,259,05000
Futu Hdgs ADRSPON ADR CL A36118L10644,5151,028,054SH DFND2802,1120225,942
GANCOMG3728V1095572SH DFND357200
Gentex CorpCOM37190110918516SH DFND351600
Ginkgo Bioworks Holdings IncCL A COM37611X10091,89311,058,139SH DFND111,058,13900
Ginkgo Bioworks Holdings IncCL A COM37611X100125,41215,091,715SH DFND215,003,715088,000
Ginkgo Bioworks Holdings IncCL A COM37611X1007,171862,975SH DFND3862,97500
Ginkgo Bioworks Holdings IncCL A COM37611X100685,05482,437,342SH SOLE082,437,34200
Glaukos CorpCOM37732210213290SH DFND229000
Glaukos CorpCOM37732210245010,118SH DFND310,11800
Global Blood Therapeutics IncCOM37890U10824835SH DFND383500
Golub Capital BDC IncCOM38173M10249,7013,218,975SH DFND13,218,97500
Golub Capital BDC IncCOM38173M1021328,560SH DFND28,56000
Golub Capital BDC IncCOM38173M1023,355217,300SH DFND3217,30000
Goodyear Tire & Rubber Co/TheCOM382550101301,400SH DFND31,40000
GracoCOM38410910429363SH DFND336300
Grainger, WWCOM3848021043159SH DFND35900
HDFC Bank ADRADR REPS 3 SHS40415F1014,01461,687SH DFND161,68700
HDFC Bank ADRADR REPS 3 SHS40415F10158,705902,175SH DFND2800,6830101,492
HDFC Bank ADRADR REPS 3 SHS40415F10111,996184,359SH DFND3134,529049,830
HDFC Bank ADRADR REPS 3 SHS40415F10177,2511,187,195SH SOLE0864,7620322,433
HUYA ADRADS REP SHS A44852D10812,0241,732,547SH DFND11,732,54700
HUYA ADRADS REP SHS A44852D10831,2324,500,342SH DFND22,407,48002,092,862
HUYA ADRADS REP SHS A44852D1082,784401,194SH DFND333,1650368,029
HUYA ADRADS REP SHS A44852D1087,0721,019,065SH SOLE01,019,06500
Halozyme TherapeuticsCOM40637H10931779SH DFND377900
Harris CorpCOM5024311091361SH DFND36100
Hashicorp IncCOM CL A41810010357,395630,437SH DFND1630,43700
Hashicorp IncCOM CL A41810010382,324904,263SH DFND2892,950011,313
Hashicorp IncCOM CL A4181001034,61450,677SH DFND350,67700
Hashicorp IncCOM CL A41810010313,622149,630SH SOLE0149,63000
Health Catalyst IncCOM42225T1072,71268,449SH DFND168,44900
Health Catalyst IncCOM42225T1075,993151,258SH DFND2151,25800
Health Catalyst IncCOM42225T1077,079178,672SH DFND3178,67200
Healthcare Services Group IncCOM4219061083157SH DFND315700
Hecla Mining CoCOM4227041068716,700SH DFND216,70000
Heron Therapeutics IncCOM4277461023308SH DFND330800
HillenbrandCOM4315711089170SH DFND317000
Home DepotCOM4370761022356SH DFND35600
Homology MedicinesCOM4380831072481SH DFND348100
Howard HughesCOM44267D10758,859578,296SH DFND1578,29600
Howard HughesCOM44267D107152,4031,497,380SH DFND21,380,9860116,394
Howard HughesCOM44267D10727,753272,680SH DFND3153,4960119,184
Howard HughesCOM44267D107114,3191,123,200SH SOLE0716,3440406,856
HubbellCOM4435106071887SH DFND38700
Hubspot IncCOM44357310082124SH DFND312400
HumanaCOM4448591022656SH DFND35600
Hutchison China MeditechSPONSORED ADR44842L1034,191119,465SH DFND1119,46500
Hutchison China MeditechSPONSORED ADR44842L1032,13860,942SH DFND2262060,680
Hutchison China MeditechSPONSORED ADR44842L1036,443183,661SH DFND3720183,589
ICICI Bank ADRADR45104G104114,6945,795,540SH DFND15,795,54000
ICICI Bank ADRADR45104G10465,5583,312,702SH DFND23,312,70200
ICICI Bank ADRADR45104G10430,2001,526,009SH DFND31,357,0270168,982
ICICI Bank ADRADR45104G1047,913399,861SH DFND4399,86100
IPG Photonics CorpCOM44980X10920,785120,747SH DFND1120,74700
IPG Photonics CorpCOM44980X10920,169117,168SH DFND240,900076,268
IPG Photonics CorpCOM44980X1099,36154,378SH DFND354,37800
IPG Photonics CorpCOM44980X10915,55090,336SH SOLE090,33600
Iac/InteractivecorpCOM44891N20829,455225,349SH DFND1225,34900
Iac/InteractivecorpCOM44891N20898,696755,079SH DFND2693,500061,579
Iac/InteractivecorpCOM44891N20818,892144,530SH DFND378,881065,649
Iac/InteractivecorpCOM44891N20879,166605,660SH SOLE0385,3240220,336
Iclick Interactive Asia GSPON ADR45113Y10419,0684,136,135SH DFND14,136,13500
Iclick Interactive Asia GSPON ADR45113Y1044,7951,040,040SH DFND21,040,04000
Iclick Interactive Asia GSPON ADR45113Y10423150,082SH DFND350,08200
Iclick Interactive Asia GSPON ADR45113Y1043,188691,490SH SOLE0691,49000
Ii-Vi IncCOM90210410833478SH DFND347800
IlluminaCOM452327109812,2282,134,969SH DFND12,134,96900
IlluminaCOM4523271094,231,84811,123,562SH DFND27,799,59703,323,965
IlluminaCOM452327109468,7201,232,046SH DFND3993,7740238,272
IlluminaCOM4523271092,278,8205,989,960SH SOLE05,189,1560800,804
InModeSHSM5425M10337526SH DFND352600
Incyte CorpCOM45337C10212165SH DFND316500
InfineraCOM45667G103282,941SH DFND32,94100
Infosys Ltd ADRSPONSORED ADR45678810829,5071,165,809SH DFND11,165,80900
Infosys Ltd ADRSPONSORED ADR45678810825,8251,020,355SH DFND294,2180926,137
Infosys Ltd ADRSPONSORED ADR45678810818,180718,300SH DFND3595,8830122,417
Infosys Ltd ADRSPONSORED ADR4567881083,871152,945SH DFND4152,94500
Inogen IncCOM45780L1045141SH DFND314100
Insmed IncCOM45766930719707SH DFND370700
Inspire Medical SystemsCOM45773010935154SH DFND315400
Intercept Pharmaceuticals IncCOM45845P1082101SH DFND310100
International Game TechnologySHSG4863A108301,024SH DFND31,02400
Intersect ENTCOM46071F10312440SH DFND344000
IntuitCOM4612021033047SH DFND34700
Intuitive SurgicalCOM NEW46120E602138,053384,227SH DFND1384,22700
Intuitive SurgicalCOM NEW46120E6021,024,7562,852,091SH DFND2946,75601,905,335
Intuitive SurgicalCOM NEW46120E602132,523368,837SH DFND3311,305057,532
Intuitive SurgicalCOM NEW46120E602286,093796,251SH SOLE0369,0280427,223
InvitaeCOM46185L10312800SH DFND380000
Ionis PharmaceuticalsCOM4622221001,65654,414SH DFND154,41400
Ionis PharmaceuticalsCOM4622221003,567117,222SH DFND2117,22200
Ionis PharmaceuticalsCOM4622221004,388144,184SH DFND3144,18400
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621069,0412,410,946SH DFND12,410,94600
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210627,5567,348,152SH DFND2529,89806,818,254
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210633,7338,995,481SH DFND3918,72808,076,753
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621061,445385,212SH DFND4385,21200
Itron IncCOM46574110614204SH DFND320400
Ivanhoe MinesCOM CL A46579R104111,400SH DFND21,40000
J&J Snack Foods CorpCOM4660321091383SH DFND38300
JD.Com Inc - ADRSPON ADR CL A47215P10697,1341,386,239SH DFND11,386,23900
JD.Com Inc - ADRSPON ADR CL A47215P1064,79168,377SH DFND268,37700
JD.Com Inc - ADRSPON ADR CL A47215P10620,456291,937SH SOLE0291,93700
JDS Uniphase CorporationCOM925550105201,142SH DFND31,14200
JFrog LtdORD SHSM6191J10017,967604,939SH DFND1604,93900
JFrog LtdORD SHSM6191J10013,514455,003SH DFND2158,0710296,932
JFrog LtdORD SHSM6191J1006,298212,045SH DFND3212,04500
JFrog LtdORD SHSM6191J10012,298414,081SH SOLE0414,08100
Jack Henry & AssociatesCOM4262811011271SH DFND37100
Jazz PharmaceuticalsSHSG5087110521165SH DFND316500
Joby Aviation IncCOMG6516310056,0447,677,200SH SOLE07,677,20000
John Wiley & Sons IncCOM9682232069153SH DFND315300
Johnson & JohnsonCOM4781601041589SH DFND38900
Jumia Technologies Ag ADRSPONSORED ADS48138M105108,1699,488,528SH DFND29,064,5850423,943
Jumia Technologies Ag ADRSPONSORED ADS48138M1054,948434,078SH DFND33740433,704
KE Holdings ADRADR48249710445,7962,276,149SH DFND12,276,14900
KE Holdings ADRADR482497104252,66112,557,726SH DFND26,328,02906,229,697
KE Holdings ADRADR48249710421,9641,091,636SH DFND3844,5030247,133
KE Holdings ADRADR48249710497,1964,830,802SH SOLE03,519,15201,311,650
Kaleido Biosciences IncCOM483347100880368,288SH DFND1368,28800
Kaleido Biosciences IncCOM48334710041,836SH DFND21,83600
Kaleido Biosciences IncCOM48334710014962,285SH DFND362,28500
Kaleido Biosciences IncCOM483347100691289,103SH SOLE0289,10300
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10135,9042,279,611SH DFND12,279,61100
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10157,9613,680,063SH DFND22,374,97901,305,084
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1015,167328,090SH DFND344,2210283,869
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1016,192393,153SH SOLE0393,15300
Knowles CorpCOM49926D109281,200SH DFND31,20000
Kulicke & Soffa Industries IncCOM50124210130491SH DFND349100
Lemonade IncCOM52567D10770,2491,668,226SH DFND11,668,22600
Lemonade IncCOM52567D10798,7212,344,361SH DFND22,314,831029,530
Lemonade IncCOM52567D1075,451129,439SH DFND3129,43900
Lemonade IncCOM52567D10735,972854,229SH SOLE0854,22900
LendingTreeCOM52603B10727,528224,539SH DFND1224,53900
LendingTreeCOM52603B10728,008228,448SH DFND289,6080138,840
LendingTreeCOM52603B10713,373109,080SH DFND3103,24705,833
LendingTreeCOM52603B10714,500118,274SH SOLE0118,27400
Li Auto ADRSPONS ADS50202M10257,9791,806,184SH DFND11,806,18400
Li Auto ADRSPONS ADS50202M102215,0946,700,755SH DFND26,185,0540515,701
Li Auto ADRSPONS ADS50202M10237,7671,176,538SH DFND3635,0850541,453
Li Auto ADRSPONS ADS50202M102158,9274,950,994SH SOLE03,223,33101,727,663
Liberty Broadband CorpCOM5303073051170SH DFND37000
Lightspeed POSCOM53227R10613310SH DFND331000
Lilium NVCL A COMN52586109405,800SH DFND15,80000
Lilium NVCL A COMN525861092,542366,800SH DFND2366,80000
Lilium NVCL A COMN52586109122,65817,699,615SH SOLE017,699,61500
LivePerson IncCOM53814610117,585492,291SH DFND1492,29100
LivePerson IncCOM53814610113,815386,766SH DFND2134,1060252,660
LivePerson IncCOM5381461015,756161,154SH DFND3161,15400
LivePerson IncCOM5381461018,854247,880SH SOLE0247,88000
Liveramp Holdings IncCOM53815P10829,508615,401SH DFND1615,40100
Liveramp Holdings IncCOM53815P10816,052334,765SH DFND2117,5190217,246
Liveramp Holdings IncCOM53815P1088,320173,506SH DFND3173,50600
Liveramp Holdings IncCOM53815P10814,149295,075SH SOLE0295,07500
Logitech International SASHSH5043023220235SH DFND323500
Lowes CosCOM5486611071869SH DFND36900
Lufax Holding LtdCOM54975P10245,4508,072,785SH DFND18,072,78500
Lufax Holding LtdCOM54975P10298,20017,442,239SH DFND29,842,53207,599,707
Lufax Holding LtdCOM54975P1021,004178,376SH DFND3178,37600
Lufax Holding LtdCOM54975P1024,519802,735SH SOLE0802,73500
Lumentum HdgsCOM55024U10915141SH DFND314100
Lyell Immunopharma IncCOM55083R104952122,986SH DFND1122,98600
Lyell Immunopharma IncCOM55083R1042,153278,187SH DFND2278,18700
Lyell Immunopharma IncCOM55083R1042,494322,197SH DFND3322,19700
Lyft Inc Class A CommonCL A COM55087P10445,7081,069,694SH DFND11,069,69400
Lyft Inc Class A CommonCL A COM55087P104145,7383,410,669SH DFND23,149,4000261,269
Lyft Inc Class A CommonCL A COM55087P10425,845604,855SH DFND3339,9020264,953
Lyft Inc Class A CommonCL A COM55087P104105,9822,480,263SH SOLE01,588,5530891,710
MELI Kaszek PioneerCL A COMG5S74L10623,1202,000,000SH DFND22,000,00000
MP MaterialsCOM CL A55336810186,7521,910,000SH DFND11,910,00000
MP MaterialsCOM CL A5533681011954,300SH DFND24,30000
MP MaterialsCOM CL A5533681014,842106,600SH DFND3106,60000
MakeMyTripSHSV5633W10967,3312,429,848SH DFND21,839,5080590,340
Marathon Digital HoldingsCOM56578810611343SH DFND334300
Markel CorpCOM57053510464,17352,004SH DFND152,00400
Markel CorpCOM570535104239,827194,349SH DFND2179,824014,525
Markel CorpCOM57053510441,14233,340SH DFND317,938015,402
Markel CorpCOM570535104173,969140,980SH SOLE091,153049,827
MarketAxess HoldingsCOM57060D108243,712592,585SH DFND1592,58500
MarketAxess HoldingsCOM57060D108349,009848,614SH DFND2720,5220128,092
MarketAxess HoldingsCOM57060D10852,505127,665SH DFND3118,55809,107
MarketAxess HoldingsCOM57060D10878,164190,054SH SOLE0190,05400
Martin Marietta MaterialsCOM573284106260,332590,965SH DFND1590,96500
Martin Marietta MaterialsCOM573284106932,2802,116,317SH DFND21,955,3220160,995
Martin Marietta MaterialsCOM573284106142,032322,420SH DFND3190,2240132,196
Martin Marietta MaterialsCOM573284106578,3681,312,920SH SOLE0937,1930375,727
Masimo CorpCOM5747951004,55315,552SH DFND115,55200
Masimo CorpCOM5747951009,89033,780SH DFND233,78000
Masimo CorpCOM57479510011,88640,597SH DFND340,59700
Mastercard Inc-Class ACL A57636Q104147,481410,445SH DFND1410,44500
Mastercard Inc-Class ACL A57636Q104550,8611,533,065SH DFND21,420,5050112,560
Mastercard Inc-Class ACL A57636Q10493,121259,160SH DFND3142,0390117,121
Mastercard Inc-Class ACL A57636Q104371,8831,034,962SH SOLE0663,9330371,029
Materialise Nv ADRSPONSORED ADS57667T1006,397268,000SH DFND2268,00000
Maxlinear IncCOM57776J10030400SH DFND340000
McDonald'sCOM58013510119,27171,887SH DFND171,88700
McDonald'sCOM5801351014941,843SH DFND2001,843
McDonald'sCOM5801351017672,861SH DFND32,86100
McDonald'sCOM58013510125,18793,958SH SOLE093,95800
Medifast IncCOM58470H10123110SH DFND311000
MedtronicCOMG5960L10316,615160,609SH DFND1160,60900
MedtronicCOMG5960L1033103,001SH DFND2003,001
MedtronicCOMG5960L1033,18230,757SH DFND330,75700
MedtronicCOMG5960L10315,799152,721SH SOLE0152,72100
MercadoLibreCOM58733R102422,625313,427SH DFND1313,42700
MercadoLibreCOM58733R1025,445,6814,038,624SH DFND23,329,8100708,814
MercadoLibreCOM58733R102247,293183,397SH DFND3152,697030,700
MercadoLibreCOM58733R1027,9335,883SH DFND45,88300
MercadoLibreCOM58733R102561,215416,208SH SOLE0416,20800
Meta Platforms IncCL A30303M102262,083779,196SH DFND1779,19600
Meta Platforms IncCL A30303M1021,506,3704,478,578SH DFND22,278,85302,199,725
Meta Platforms IncCL A30303M102211,320628,274SH DFND3460,6940167,580
Meta Platforms IncCL A30303M102619,7451,842,559SH SOLE01,035,9000806,659
Mettler-ToledoCOM592688105168,39099,216SH DFND199,21600
Mettler-ToledoCOM592688105695,389409,725SH DFND2300,7000109,025
Mettler-ToledoCOM5926881056,7703,989SH DFND33,98900
Mettler-ToledoCOM59268810542,70925,164SH SOLE025,16400
MicrosoftCOM594918104327,831974,759SH DFND1974,75900
MicrosoftCOM5949181041,073,0133,190,453SH DFND22,963,5940226,859
MicrosoftCOM594918104184,053547,256SH DFND3312,7990234,457
MicrosoftCOM594918104752,7432,238,174SH SOLE01,491,5640746,610
Mobile Telesystems ADRSPONSORED ADR60740910923629,700SH DFND129,70000
Moderna IncCOM60770K1071,267,1104,989,015SH DFND14,989,01500
Moderna IncCOM60770K1076,422,44825,287,218SH DFND219,443,89605,843,322
Moderna IncCOM60770K107652,2262,568,020SH DFND32,052,8510515,169
Moderna IncCOM60770K1073,283,40912,927,826SH SOLE011,388,82801,538,998
Momentive Global IncCOM78489X103231,095SH DFND31,09500
MongoDB IncCOM60937P106106201SH DFND320100
Monolithic Power Systems IncCOM6098391053163SH DFND36300
Moody's CorpCOM615369105267,379684,570SH DFND1684,57000
Moody's CorpCOM6153691051,006,0972,575,906SH DFND22,382,1040193,802
Moody's CorpCOM615369105169,695434,469SH DFND3233,9740200,495
Moody's CorpCOM615369105690,2261,767,182SH SOLE01,125,8390641,343
NIO Inc ADRSPON ADS62914V10665,2862,060,793SH DFND12,060,79300
NIO Inc ADRSPON ADS62914V1061,843,25158,183,426SH DFND245,072,456013,110,970
NIO Inc ADRSPON ADS62914V10660,2171,900,790SH DFND31,592,9680307,822
NIO Inc ADRSPON ADS62914V106846,27926,713,356SH SOLE024,418,08402,295,272
NV5 GlobalCOM62945V10919138SH DFND313800
NVIDIACOM67066G104648,3752,204,533SH DFND12,204,53300
NVIDIACOM67066G1042,876,5459,780,507SH DFND24,414,97205,365,535
NVIDIACOM67066G104326,2171,109,167SH DFND3939,2020169,965
NVIDIACOM67066G1041,519,0895,165,037SH SOLE04,024,62901,140,408
Nano Dimension ADRSPONS ADS63008G20361,600SH DFND31,60000
Nanobiotix ADRCOM63009J1077,045850,841SH DFND1850,84100
Nanobiotix ADRCOM63009J1074,547549,159SH SOLE0549,15900
National Instruments CorpCOM63651810223,757544,010SH DFND1544,01000
National Instruments CorpCOM6365181024369,980SH DFND2009,980
National Instruments CorpCOM6365181024,856111,191SH DFND3111,19100
National Instruments CorpCOM63651810222,057505,090SH SOLE0505,09000
Nektar TherapeuticsCOM640268108191,376SH DFND31,37600
NetEase.com ADRSPONSORED ADR64110W10215,710154,351SH DFND1154,35100
NetEase.com ADRSPONSORED ADR64110W10210,563103,787SH DFND24470103,340
NetEase.com ADRSPONSORED ADR64110W10216154SH DFND315400
Netflix IncCOM64110L106742,9031,233,156SH DFND11,233,15600
Netflix IncCOM64110L1062,425,6724,026,412SH DFND22,295,21801,731,194
Netflix IncCOM64110L106283,931471,302SH DFND3381,396089,906
Netflix IncCOM64110L1061,258,9642,089,775SH SOLE01,606,0250483,750
Nevro CorpCOM64157F10312154SH DFND315400
New RelicCOM64829B10077704SH DFND370400
Newmont MiningCOM6516391061,25120,172SH DFND120,17200
NextEra EnergyCOM65339F10171,471765,543SH DFND1765,54300
NextEra EnergyCOM65339F1012032,170SH DFND22,17000
NextEra EnergyCOM65339F1014,94652,977SH DFND352,97700
NikeCOM6541061031590SH DFND39000
Novanta IncCOM67000B10436206SH DFND220600
Novanta IncCOM67000B1041,2296,970SH DFND36,97000
Novavax IncCOM NEW67000240119130SH DFND313000
Novocure LtdORD SHSG6674U108198,1992,639,843SH DFND12,639,84300
Novocure LtdORD SHSG6674U108330,0134,395,487SH DFND23,907,4520488,035
Novocure LtdORD SHSG6674U10854,002719,257SH DFND3584,1230135,134
Novocure LtdORD SHSG6674U108139,6921,860,581SH SOLE01,426,3660434,215
Nu Holdings Ltd.ORD SHS CL AG6683N10359,0936,299,905SH DFND16,299,90500
Nu Holdings Ltd.ORD SHS CL AG6683N103133,52814,235,430SH DFND212,659,13201,576,298
Nu Holdings Ltd.ORD SHS CL AG6683N10357,9076,173,437SH DFND34,900,42701,273,010
Nu Holdings Ltd.ORD SHS CL AG6683N1035,397575,423SH SOLE0575,42300
Nucana Plc ADRSPONSORED ADR67022C1065,7602,420,041SH DFND12,420,04100
Nucana Plc ADRSPONSORED ADR67022C1062,9491,238,989SH SOLE01,238,98900
Nutanix IncCOM67059N10818563SH DFND356300
Oatly Inc.SPONS ADS67421J108179,59422,562,028SH DFND219,300,92903,261,099
Oatly Inc.SPONS ADS67421J1088,4531,061,969SH SOLE01,061,96900
On Semiconductor CorpCOM68218910534500SH DFND350000
OneConnect Financial Technology ADRCOM68248T1055,0752,054,800SH DFND12,054,80000
OneConnect Financial Technology ADRCOM68248T1051,683681,340SH DFND2251,8220429,518
OneConnect Financial Technology ADRCOM68248T105712288,299SH DFND3288,29900
Opko Health IncCOM68375N103326,635SH DFND36,63500
Oscar Health IncCOM68779310922,9232,920,163SH DFND12,920,16300
Oscar Health IncCOM68779310980,28310,227,082SH DFND29,036,35901,190,723
Oscar Health IncCOM68779310914,8561,892,509SH DFND31,073,2450819,264
Oscar Health IncCOM68779310965,0358,284,742SH SOLE05,707,07602,577,666
Outset MedicalCOM69014510716346SH DFND334600
Oxford Industries IncCOM691497309773SH DFND37300
Ozon HoldingsCOM69269L1049,889333,970SH DFND1333,97000
Ozon HoldingsCOM69269L10474,9372,530,813SH DFND21,371,96801,158,845
Ozon HoldingsCOM69269L10457119,278SH DFND319,27800
PROCEPT BioRoboticsCOM74276L1059376SH DFND337600
Pacific Biosciences of CaliforniaCOM69404D10811561SH DFND356100
Pacira BioSciencesCOM69512710064,5061,072,068SH DFND11,072,06800
Pacira BioSciencesCOM69512710036,851612,450SH DFND2291,2210321,229
Pacira BioSciencesCOM69512710020,569341,850SH DFND3297,663044,187
Pacira BioSciencesCOM69512710019,788328,872SH SOLE0328,87200
PagerDutyCOM69553P10017503SH DFND350300
Pagseguro Digital LtdCOM CL AG687071014148SH DFND214800
Pan American Silver CorpCOM6979001081124,500SH DFND24,50000
PaychexCOM70432610716116SH DFND311600
Peloton Interactive IncCL A COM70614W100173,3844,848,548SH DFND14,848,54800
Peloton Interactive IncCL A COM70614W100647,97118,119,982SH DFND28,939,33109,180,651
Peloton Interactive IncCL A COM70614W100105,0042,936,354SH DFND32,322,3110614,043
Peloton Interactive IncCL A COM70614W100203,9885,704,373SH SOLE03,117,82102,586,552
Penumbra IncCOM70975L107145,738507,231SH DFND1507,23100
Penumbra IncCOM70975L107192,790670,995SH DFND2662,63008,365
Penumbra IncCOM70975L10711,10538,652SH DFND338,65200
Penumbra IncCOM70975L10730,398105,799SH SOLE0105,79900
PepsicoCOM71344810840,145231,104SH DFND1231,10400
PepsicoCOM7134481087374,244SH DFND2004,244
PepsicoCOM7134481088,17747,071SH DFND347,07100
PepsicoCOM71344810838,212219,977SH SOLE0219,97700
Petrobras Common ADRSPONSORED ADR71654V408211,89619,298,337SH DFND119,298,33700
Petrobras Common ADRSPONSORED ADR71654V408704,24264,138,632SH DFND228,339,595035,799,037
Petrobras Common ADRSPONSORED ADR71654V408191,51217,441,898SH DFND32,940,124014,501,774
Petrobras Common ADRSPONSORED ADR71654V4089,863898,231SH DFND4898,23100
Petrobras Common ADRSPONSORED ADR71654V40812,3981,129,188SH SOLE01,129,18800
Petrobras Pref ADRSP ADR NON VTG71654V10119,3441,913,345SH DFND11,913,34500
Petrobras Pref ADRSP ADR NON VTG71654V101136,24413,476,146SH DFND28,058,44905,417,697
Petrobras Pref ADRSP ADR NON VTG71654V1011,129111,646SH DFND3111,64600
PfizerCOM71708110330500SH DFND350000
Piedmont Lithium IncCOM72016P10511212SH DFND321200
Pinduoduo Inc ADRSPONSORED ADS722304102108,4031,859,406SH DFND11,859,40600
Pinduoduo Inc ADRSPONSORED ADS7223041021,003,77417,217,392SH DFND28,184,08309,033,309
Pinduoduo Inc ADRSPONSORED ADS72230410299,5781,708,024SH DFND31,445,3100262,714
Pinduoduo Inc ADRSPONSORED ADS722304102484,8788,316,944SH SOLE06,356,04001,960,904
PinterestCOM72352L10687,0662,395,207SH DFND12,395,20700
PinterestCOM72352L106124,4433,423,479SH DFND23,382,457041,022
PinterestCOM72352L1066,697184,238SH DFND3184,23800
PinterestCOM72352L10619,632540,069SH SOLE0540,06900
Plantronics IncCOM7274931087254SH DFND325400
Precision BioSciences IncCOM74019P108111,468SH DFND21,46800
Precision BioSciences IncCOM74019P10836749,607SH DFND349,60700
Procter & GambleCOM74271810949,468302,409SH DFND1302,40900
Procter & GambleCOM7427181099055,534SH DFND2005,534
Procter & GambleCOM7427181099,97860,996SH DFND360,99600
Procter & GambleCOM74271810947,335289,367SH SOLE0289,36700
ProgynyCOM74340E10320396SH DFND339600
Prologis Inc REITCOM74340W10390,366536,740SH DFND1536,74000
Prologis Inc REITCOM74340W1032281,357SH DFND21,35700
Prologis Inc REITCOM74340W1034,08324,254SH DFND324,25400
Proterra IncCOM74374T1099410,600SH DFND110,60000
Ptc Therapeutics IncCOM69366J20010246SH DFND324600
Pure Storage IncCOM74624M102411,261SH DFND31,26100
Q2 Holdings IncCOM74736L10925,289318,346SH DFND1318,34600
Q2 Holdings IncCOM74736L10915,520195,369SH DFND268,4220126,947
Q2 Holdings IncCOM74736L1097,64396,212SH DFND396,21200
Q2 Holdings IncCOM74736L1099,710122,235SH SOLE0122,23500
Quaker Chemical CorpCOM7473161072086SH DFND38600
QualcommCOM74752510333181SH DFND318100
Quanterix CorpCOM74766Q10116,584391,135SH DFND1391,13500
Quanterix CorpCOM74766Q10132746SH DFND274600
Quanterix CorpCOM74766Q1011,06225,044SH DFND325,04400
Quanterix CorpCOM74766Q1018,890209,677SH SOLE0209,67700
QuantumScape CorpCOM CL A74767V109652,914SH DFND12,91400
QuantumScape CorpCOM CL A74767V10920,266913,279SH SOLE0913,27900
Quest DiagnosticsCOM74834L10025145SH DFND314500
Quidel CorpCOM74838J10117128SH DFND312800
Rambus IncCOM75091710619630SH DFND363000
Recursion Pharmaceuticals IncCL A75629V10449,8632,910,856SH DFND12,910,85600
Recursion Pharmaceuticals IncCL A75629V10469,2364,041,816SH DFND23,994,295047,521
Recursion Pharmaceuticals IncCL A75629V1049,925579,393SH DFND3579,39300
Recursion Pharmaceuticals IncCL A75629V104249,94514,591,090SH SOLE014,591,09000
RedfinCOM75737F108155,3174,045,778SH DFND14,045,77800
RedfinCOM75737F108198,6025,173,280SH DFND25,076,084097,196
RedfinCOM75737F10816,867439,353SH DFND3397,756041,597
RedfinCOM75737F10829,131758,812SH SOLE0758,81200
Regeneron PharmaceuticalsCOM75886F1072946SH DFND34600
Relay Therapeutics IncCOM75943R1021,19939,053SH DFND139,05300
Relay Therapeutics IncCOM75943R1022,54082,714SH DFND282,71400
Relay Therapeutics IncCOM75943R1023,172103,274SH DFND3103,27400
ResMedCOM7611521074,32816,616SH DFND116,61600
ResMedCOM7611521079,01734,618SH DFND234,61800
ResMedCOM76115210711,31443,436SH DFND343,43600
Research in MotionCOM09228F103262,731SH DFND32,73100
Rexford Industrial Realty REITCOM76169C10088,9041,096,090SH DFND11,096,09000
Rexford Industrial Realty REITCOM76169C1002292,826SH DFND22,82600
Rexford Industrial Realty REITCOM76169C1004,01349,477SH DFND349,47700
Ringcentral IncCOM76680R20663337SH DFND333700
Ritchie Bros Auctioneers (USA)COM767744105102,1781,669,296SH DFND21,525,5850143,711
Ritchie Bros. AuctioneersCOM76774410564,6281,054,573SH DFND2604,3050450,268
Rivian Automotive IncCOM CL A76954A103138,7121,337,754SH DFND11,337,75400
Rivian Automotive IncCOM CL A76954A103187,6411,809,634SH DFND21,786,979022,655
Rivian Automotive IncCOM CL A76954A10310,596102,191SH DFND3102,19100
Rivian Automotive IncCOM CL A76954A10332,139309,954SH SOLE0309,95400
Robert Half International IncCOM77032310315131SH DFND313100
RokuCOM CL A77543R102308,6061,352,347SH DFND11,352,34700
RokuCOM CL A77543R102433,6741,900,414SH DFND21,877,125023,289
RokuCOM CL A77543R10224,151105,832SH DFND3105,83200
RokuCOM CL A77543R10265,222285,812SH SOLE0285,81200
Rollins IncCOM77571110419562SH DFND356200
Royal Caribbean CruisesCOMV7780T10313,142170,894SH DFND1170,89400
Royal Caribbean CruisesCOMV7780T10377410,063SH DFND310,06300
Rubius Therapeutics IncCOM78116T1038,586887,000SH DFND1887,00000
Rubius Therapeutics IncCOM78116T1032,992309,114SH DFND2107,4880201,626
Rubius Therapeutics IncCOM78116T1031,444149,186SH DFND3149,18600
Rubius Therapeutics IncCOM78116T10334,7083,585,559SH SOLE03,585,55900
Ryanair ADRSPONSORED ADR NE78351320369,988683,946SH DFND1683,94600
Ryanair ADRSPONSORED ADR NE783513203996,1439,734,610SH DFND28,658,05401,076,556
Ryanair ADRSPONSORED ADR NE7835132037,22570,604SH DFND370,60400
Ryanair ADRSPONSORED ADR NE78351320315,215148,688SH SOLE0148,68800
S&P Global IncCOM78409V104110,392233,916SH DFND1233,91600
S&P Global IncCOM78409V104420,677891,398SH DFND2825,950065,448
S&P Global IncCOM78409V10469,801147,906SH DFND380,173067,733
S&P Global IncCOM78409V104290,623615,819SH SOLE0397,1160218,703
SCP Pool CorporationCOM73278L1053766SH DFND36600
SEA Ltd ADRADR81141R100525,7052,349,940SH DFND12,349,94000
SEA Ltd ADRADR81141R1001,073,5734,798,949SH DFND23,912,9230886,026
SEA Ltd ADRADR81141R100117,458525,047SH DFND3290,7690234,278
SEA Ltd ADRADR81141R100520,3592,326,043SH SOLE01,590,4250735,618
Sage Therapeutics IncCOM78667J10861914,553SH DFND114,55300
Sage Therapeutics IncCOM78667J1081,44333,912SH DFND233,91200
Sage Therapeutics IncCOM78667J1081,78341,907SH DFND341,90700
Sailpoint Technologies HoldingCOM78781P10519388SH DFND338800
Salesforce.comCOM79466L30282,637325,178SH DFND1325,17800
Salesforce.comCOM79466L302628,6352,473,674SH DFND2874,30001,599,374
Salesforce.comCOM79466L30277,993306,901SH DFND3258,220048,681
Salesforce.comCOM79466L302171,593675,218SH SOLE0312,9850362,233
Sana Biotechnology IncCOM79956610432,1992,080,021SH DFND12,080,02100
Sana Biotechnology IncCOM79956610445,1322,915,474SH DFND22,915,47400
Sana Biotechnology IncCOM7995661043,436221,987SH DFND3221,98700
Sana Biotechnology IncCOM79956610493,5706,044,548SH SOLE06,044,54800
Sarepta Therapeutics IncCOM80360710016177SH DFND317700
SchrodingerCOM80810D1038242SH DFND324200
Schweitzer-Maudit Int.COM8085411068265SH DFND326500
Seagen IncCOM81181C10420128SH DFND312800
SeerCOM CL A81578P1065223SH DFND322300
Sei Investments CoCOM78411710327438SH DFND343800
Service Corp.Intl.COM817565104160,0942,255,168SH DFND12,255,16800
Service Corp.Intl.COM817565104599,8978,450,441SH DFND27,820,4970629,944
Service Corp.Intl.COM817565104101,3091,427,089SH DFND3775,0140652,075
Service Corp.Intl.COM817565104418,4765,894,864SH SOLE03,781,43502,113,429
Shake Shack IncCOM81904710113174SH DFND317400
Sherwin-Williams CoCOM82434810615,65544,453SH DFND244,45300
ShockWave Medical IncCOM82489T10426,410148,098SH DFND1148,09800
ShockWave Medical IncCOM82489T10435,938201,523SH DFND2118,219083,304
ShockWave Medical IncCOM82489T10426,965151,207SH DFND3151,20700
ShockWave Medical IncCOM82489T10415,31785,892SH SOLE085,89200
Shopify 'A'CL A82509L1071,533,2141,113,130SH DFND11,113,13000
Shopify 'A'CL A82509L1074,020,4212,918,869SH DFND22,028,7980890,071
Shopify 'A'CL A82509L107512,846372,332SH DFND3291,835080,497
Shopify 'A'CL A82509L1071,427,6791,036,510SH SOLE0771,7840264,726
Shopify IncCOM82509L10713,3789,702SH DFND29,70200
Shopify IncCOM82509L107248180SH DFND318000
Silicon Laboratories IncCOM82691910224116SH DFND311600
Silicon Motion Technology ADRCOM82706C10831,725333,844SH DFND1333,84400
Silicon Motion Technology ADRCOM82706C1084945,203SH DFND2005,203
Silicon Motion Technology ADRCOM82706C1086,34666,779SH DFND366,77900
Silicon Motion Technology ADRCOM82706C10830,805324,164SH SOLE0324,16400
Silk Road MedicalCOM82710M10010235SH DFND323500
SiteOne Landscape SupplyCOM82982L103115,523476,816SH DFND1476,81600
SiteOne Landscape SupplyCOM82982L103418,6361,727,901SH DFND21,597,4920130,409
SiteOne Landscape SupplyCOM82982L10373,643303,960SH DFND3163,0190140,941
SiteOne Landscape SupplyCOM82982L103297,0151,225,915SH SOLE0784,7480441,167
Six Flags Entertainment CorpCOM83001A10214,931350,649SH DFND1350,64900
Six Flags Entertainment CorpCOM83001A10287820,611SH DFND320,61100
Sixth Street Specialty LendingCOM83012A10945,1431,930,000SH DFND11,930,00000
Sixth Street Specialty LendingCOM83012A1091406,000SH DFND26,00000
Sixth Street Specialty LendingCOM83012A1093,597153,800SH DFND3153,80000
SmartsheetCOM83200N10324311SH DFND331100
Snap IncCL A83304A106205,5874,371,405SH DFND14,371,40500
Snap IncCL A83304A106281,9295,994,671SH DFND25,919,961074,710
Snap IncCL A83304A10616,108342,505SH DFND3342,50500
Snap IncCL A83304A10647,0581,000,588SH SOLE01,000,58800
Snowflake IncCOM833445109261,298771,358SH DFND1771,35800
Snowflake IncCOM833445109535,7931,581,677SH DFND21,513,429068,248
Snowflake IncCOM83344510959,936176,932SH DFND3115,906061,026
Snowflake IncCOM833445109496,7131,466,312SH SOLE01,269,0610197,251
Sohu.comCOM83410S1083,258200,140SH DFND300200,140
Solaredge Technologies IncCOM83417M1044091,459SH DFND11,45900
Solaredge Technologies IncCOM83417M10444156SH DFND315600
Sorrento TherapeuticsCOM83587F202204,314SH DFND34,31400
Spire Global IncCOM CL A8485601082,927866,045SH SOLE0866,04500
Splunk IncCOM84863710411,681100,940SH DFND1100,94000
Splunk IncCOM84863710416,636143,764SH DFND249,601094,163
Splunk IncCOM8486371046,94259,992SH DFND359,99200
Splunk IncCOM8486371048,55073,884SH SOLE073,88400
Spotify Technology SASHSL8681T102321,8561,375,276SH DFND11,375,27600
Spotify Technology SASHSL8681T1024,004,88517,112,698SH DFND212,707,01304,405,685
Spotify Technology SASHSL8681T102122,790524,675SH DFND3413,8660110,809
Spotify Technology SASHSL8681T102731,1693,124,253SH SOLE02,536,4670587,786
Sprout SocialCOM85209W10929,119321,078SH DFND1321,07800
Sprout SocialCOM85209W10916,902186,371SH DFND264,2430122,128
Sprout SocialCOM85209W1098,98099,022SH DFND399,02200
Sprout SocialCOM85209W10918,108199,670SH SOLE0199,67000
Staar SurgicalCOM PAR $0.01852312305135,6741,486,021SH DFND11,486,02100
Staar SurgicalCOM PAR $0.01852312305187,0442,048,676SH DFND21,545,5460503,130
Staar SurgicalCOM PAR $0.0185231230551,591565,073SH DFND3428,2480136,825
Staar SurgicalCOM PAR $0.01852312305130,5681,430,098SH SOLE01,091,3730338,725
Starbucks CorpCOM85524410917,563150,147SH DFND1150,14700
Starbucks CorpCOM8552441093032,593SH DFND2002,593
Starbucks CorpCOM8552441093,95733,828SH DFND333,82800
Starbucks CorpCOM85524410917,598150,451SH SOLE0150,45100
Stericycle IncCOM85891210834,306575,216SH DFND1575,21600
Stericycle IncCOM858912108131,5792,206,213SH DFND22,042,9720163,241
Stericycle IncCOM85891210822,299373,888SH DFND3204,0380169,850
Stericycle IncCOM85891210894,6521,587,064SH SOLE01,039,7900547,274
Stitch FixCOM CL A86089710716828SH DFND282800
Stitch FixCOM CL A86089710753228,092SH DFND328,09200
StoneCoCOM CL AG851581062,704160,397SH DFND1160,39700
StoneCoCOM CL AG8515810622,3491,325,566SH DFND2761,7650563,801
StoneCoCOM CL AG851581061549,131SH DFND39,13100
StoneCo Brazil DRCOM CL AG851581061196,994SH DFND36,99400
StratasysSHSM855481015,542226,300SH DFND1226,30000
StratasysSHSM855481019,086371,026SH DFND2123,9760247,050
StratasysSHSM855481014,110167,843SH DFND3167,84300
StratasysSHSM855481013,541144,600SH SOLE0144,60000
StrykerCOM8636671011454SH DFND35400
Summit Therapeutics New ListingCOM86627T108577214,617SH DFND1214,61700
Summit Therapeutics New ListingCOM86627T108597221,895SH SOLE0221,89500
Sumo LogicCOM86646P10310726SH DFND372600
Sunpower CorpCOM867652406241,171SH DFND31,17100
Sutro BiopharmaCOM86936710215,5111,042,428SH DFND11,042,42800
Sutro BiopharmaCOM869367102271,786SH DFND21,78600
Sutro BiopharmaCOM86936710289760,310SH DFND360,31000
Sutro BiopharmaCOM86936710211,171750,726SH SOLE0750,72600
T. Rowe PriceCOM74144T10819,52999,311SH DFND199,31100
T. Rowe PriceCOM74144T1083661,859SH DFND2001,859
T. Rowe PriceCOM74144T1084,06020,649SH DFND320,64900
T. Rowe PriceCOM74144T10819,34198,357SH SOLE098,35700
TAL Education Group ADRADS REPSTG COM87408010442,91510,919,769SH DFND210,275,5690644,200
TJX CompaniesCOM8725401096,59786,893SH DFND286,89300
TSMC ADRSPONSORED ADR874039100776,2296,451,907SH DFND25,069,80501,382,102
TSMC ADRSPONSORED ADR8740391001,96816,356SH DFND316,35600
TSMC ADRSPONSORED ADR874039100109,225907,859SH SOLE0735,7850172,074
Tabula Rasa HealthCare IncCOM8733791018,418561,175SH DFND1561,17500
Tabula Rasa HealthCare IncCOM8733791012,728181,861SH DFND262,3700119,491
Tabula Rasa HealthCare IncCOM8733791011,49899,887SH DFND399,88700
Tabula Rasa HealthCare IncCOM8733791013,579238,574SH SOLE0238,57400
Tandem Diabetes CareCOM NEW87537220329,832198,192SH DFND1198,19200
Tandem Diabetes CareCOM NEW87537220344295SH DFND229500
Tandem Diabetes CareCOM NEW8753722031,51810,088SH DFND310,08800
Tandem Diabetes CareCOM NEW87537220322,334148,377SH SOLE0148,37700
Target CorpCOM87612E10624105SH DFND310500
Tata Motors Ltd ADRCOM876568502131,2664,090,544SH DFND14,090,54400
Tata Motors Ltd ADRCOM876568502101,6143,166,543SH DFND23,166,54300
Tata Motors Ltd ADRCOM8765685022,38074,160SH DFND374,16000
Tata Motors Ltd ADRCOM87656850254,5861,701,035SH SOLE01,701,03500
TeladocCOM87918A105299,9173,266,359SH DFND13,266,35900
TeladocCOM87918A105381,8174,158,317SH DFND23,555,3880602,929
TeladocCOM87918A105151,0561,645,127SH DFND31,313,6160331,511
TeladocCOM87918A105165,9431,807,260SH SOLE01,391,2130416,047
Telus CorpCOM87971M1039397SH DFND339700
Tenable HoldingsCOM88025T10217315SH DFND331500
Tencent Music Entertainment ADRSPONSORED ADS88034P10929,7404,341,644SH DFND14,341,64400
Tencent Music Entertainment ADRSPONSORED ADS88034P109263,12038,411,694SH DFND228,646,55809,765,136
Tencent Music Entertainment ADRSPONSORED ADS88034P10911,9171,739,765SH DFND3986,0040753,761
Tencent Music Entertainment ADRSPONSORED ADS88034P10947,8856,990,456SH SOLE04,418,24102,572,215
TeradyneCOM880770102135,942831,299SH DFND1831,29900
TeradyneCOM880770102490,1272,997,169SH DFND22,766,8830230,286
TeradyneCOM88077010285,846524,956SH DFND3282,5470242,409
TeradyneCOM880770102350,1652,141,288SH SOLE01,372,3080768,980
Tesla IncCOM88160R1011,464,5701,385,880SH DFND11,385,88000
Tesla IncCOM88160R1016,513,8906,163,904SH DFND24,443,52401,720,380
Tesla IncCOM88160R101714,104675,736SH DFND3537,0750138,661
Tesla IncCOM88160R1012,718,5602,572,494SH SOLE02,125,2870447,207
Texas Roadhouse IncCOM88268110912131SH DFND313100
The Trade DeskCOM CL A88339J1051,074,69211,727,321SH DFND111,727,32100
The Trade DeskCOM CL A88339J1052,671,43229,151,378SH DFND220,851,54008,299,838
The Trade DeskCOM CL A88339J105299,6313,269,653SH DFND32,527,5940742,059
The Trade DeskCOM CL A88339J105843,5509,205,046SH SOLE05,952,96403,252,082
Thermo Fisher ScientificCOM883556102124,566186,688SH DFND1186,68800
Thermo Fisher ScientificCOM883556102475,849713,160SH DFND2662,747050,413
Thermo Fisher ScientificCOM88355610277,577116,266SH DFND362,971053,295
Thermo Fisher ScientificCOM883556102316,924474,978SH SOLE0305,2370169,741
Thor Industries IncCOM88516010114133SH DFND313300
Toro CoCOM89109210824245SH DFND324500
Tractor Supply CoCOM89235610632136SH DFND313600
TransMedics GroupCOM89377M10916822SH DFND282200
TransMedics GroupCOM89377M10953928,149SH DFND328,14900
Trip.com Group Sponsored ADRAMERICAN DEP SHS89677Q10778,8003,200,641SH DFND22,589,2280611,413
TrupanionCOM89820210626,089197,600SH DFND1197,60000
TrupanionCOM89820210647,107356,791SH DFND2122,6700234,121
TrupanionCOM89820210621,332161,568SH DFND3161,56800
TrupanionCOM89820210697,042735,000SH SOLE0735,00000
TuSimple HdgsCL A90089L10813349SH DFND334900
Twilio IncCL A90138F102451,0911,712,962SH DFND11,712,96200
Twilio IncCL A90138F102835,9493,174,408SH DFND23,046,8700127,538
Twilio IncCL A90138F10293,494355,031SH DFND3243,5080111,523
Twilio IncCL A90138F102319,6071,213,667SH SOLE0880,6010333,066
UltragenyxCOM90400D10810115SH DFND311500
United Parcel ServiceCL B91131210657,072266,270SH DFND1266,27000
United Parcel ServiceCL B9113121061,0684,981SH DFND2004,981
United Parcel ServiceCL B91131210610,93951,035SH DFND351,03500
United Parcel ServiceCL B91131210655,558259,205SH SOLE0259,20500
UnitedHealthCOM91324P1023263SH DFND36300
Unity Biotechnology IncCOM91381U101362248,000SH DFND1248,00000
Unity Biotechnology IncCOM91381U101498341,111SH SOLE0341,11100
Upwork IncCOM91688F10484,5662,475,575SH DFND12,475,57500
Upwork IncCOM91688F10459,7281,748,467SH DFND2738,19401,010,273
Upwork IncCOM91688F10429,693869,237SH DFND3792,935076,302
Upwork IncCOM91688F10441,4471,213,324SH SOLE01,213,32400
Uxin ADRADS91818X1081,9141,211,500SH DFND11,211,50000
Uxin ADRADS91818X108892564,600SH SOLE0564,60000
Vale SA ADRADR91912E10522,7241,620,823SH DFND11,620,82300
Vale SA ADRADR91912E105173,79012,395,897SH DFND26,564,71405,831,183
Vale SA ADRADR91912E1051,32094,127SH DFND394,12700
Varonis Systems IncCOM92228010226525SH DFND252500
Varonis Systems IncCOM92228010288618,166SH DFND318,16600
Vedanta Ltd ADRCOM92242Y10022,1531,206,000SH DFND11,206,00000
Vedanta Ltd ADRCOM92242Y1001,71993,606SH DFND393,60600
Vedanta Ltd ADRCOM92242Y10026,4811,441,655SH SOLE01,441,65500
Veeco InstrumentsCOM92241710016,708586,854SH DFND1586,85400
Veeco InstrumentsCOM92241710015,134531,586SH DFND2186,0060345,580
Veeco InstrumentsCOM9224171007,490263,088SH DFND3263,08800
Veeva Systems Inc Class ACOM9224751081,7306,770SH DFND16,77000
Veeva Systems Inc Class ACOM9224751083,90615,287SH DFND215,28700
Veeva Systems Inc Class ACOM9224751084,63818,156SH DFND318,15600
Veoneer IncCOM92336X10925700SH DFND370000
Verint Systems IncCOM92343X10021395SH DFND339500
Verisk AnalyticsCOM92345Y10611,55050,495SH DFND250,49500
VeritoneCOM92347M10015649SH DFND364900
ViewRayCOM92672L1075911SH DFND391100
Vimeo Inc.COM92719V10017,866994,740SH DFND1994,74000
Vimeo Inc.COM92719V10063,4583,533,298SH DFND23,110,1640423,134
Vimeo Inc.COM92719V10011,234625,479SH DFND3339,4200286,059
Vimeo Inc.COM92719V10048,0142,673,360SH SOLE01,723,7260949,634
Vir Biotechnology IncCOM92764N1021,21929,123SH DFND129,12300
Vir Biotechnology IncCOM92764N1022,65363,371SH DFND263,37100
Vir Biotechnology IncCOM92764N1023,30478,903SH DFND378,90300
Vir Biotechnology IncCOM92764N102156,7663,744,104SH SOLE03,744,10400
Visa Inc-Class A SharesCOM CL A92826C83911,35352,389SH DFND252,38900
Visa Inc-Class A SharesCOM CL A92826C83924110SH DFND311000
Visteon CorpCOM92839U20626230SH DFND323000
Vroom IncCOM92918V10945,5984,225,994SH DFND14,225,99400
Vroom IncCOM92918V10969,2986,422,433SH DFND26,341,677080,756
Vroom IncCOM92918V1093,407315,764SH DFND3315,76400
Vroom IncCOM92918V1099,719900,787SH SOLE0900,78700
VuzixCOM92921W3008924SH DFND392400
Vyne Therapeutics IncCOM92941V2095048,706SH DFND148,70600
Vyne Therapeutics IncCOM92941V2095150,056SH SOLE050,05600
WD-40 CoCOM9292361071458SH DFND35800
WEC Energy GroupCOM92939U1061,70517,566SH DFND117,56600
Wal-Mart StoresCOM93114210315101SH DFND310100
Warby Parker IncCL A COM93403J1067,583162,859SH DFND1162,85900
Warby Parker IncCL A COM93403J10625,884555,928SH DFND2253,5880302,340
Warby Parker IncCL A COM93403J1063,43973,869SH DFND350,200023,669
Warby Parker IncCL A COM93403J106225,8074,849,805SH SOLE04,849,80500
WatersCOM9418481039,41225,259SH DFND125,25900
WatersCOM94184810313,47136,155SH DFND233,35502,800
WatersCOM9418481034,23211,359SH DFND37,82003,539
WatersCOM941848103250672SH SOLE067200
Watsco IncCOM942622200246,411787,559SH DFND1787,55900
Watsco IncCOM942622200302,292966,161SH DFND2948,800017,361
Watsco IncCOM94262220028,71691,781SH DFND385,82505,956
Watsco IncCOM94262220075,258240,533SH SOLE0240,53300
Wayfair Inc Class ACL A94419L101515,1102,711,536SH DFND12,711,53600
Wayfair Inc Class ACL A94419L101830,1404,369,850SH DFND24,149,5940220,256
Wayfair Inc Class ACL A94419L10187,805462,205SH DFND3361,3460100,859
Wayfair Inc Class ACL A94419L101513,9822,705,593SH SOLE02,414,2240291,369
Wheaton Precious MetalsCOM96287910287620,416SH DFND120,41600
Williams-Sonoma IncCOM9699041011163SH DFND36300
Wix ComSHSM98068105515,1133,264,548SH DFND22,013,27001,251,278
Wix ComSHSM9806810562390SH DFND339000
Workday IncCL A98138H101404,1321,479,363SH DFND11,479,36300
Workday IncCL A98138H1011,473,2555,392,981SH DFND22,647,49202,745,489
Workday IncCL A98138H101169,692621,173SH DFND3527,634093,539
Workday IncCL A98138H101363,6101,331,026SH SOLE0720,1220610,904
XPCL AG982391091,96568,387SH DFND168,38700
XPCL AG982391095,151179,222SH DFND215,9820163,240
XPCL AG982391096,000208,760SH DFND322,2860186,474
XPCL AG982391092568,893SH DFND48,89300
XPELCOM98379L10020295SH DFND329500
Xencor IncCOM98401F10533828SH DFND282800
Xencor IncCOM98401F1051,14328,479SH DFND328,47900
Xperi Holding CorpCOM98390M103291,549SH DFND31,54900
XylemCOM98419M100127,8251,065,917SH DFND11,065,91700
XylemCOM98419M10035,369294,939SH DFND2115,4770179,462
XylemCOM98419M100127,8501,066,125SH DFND3847,7800218,345
XylemCOM98419M10011,11392,673SH SOLE092,67300
Yatsen Holding Ltd ADRCOM9851941091,725802,289SH DFND1802,28900
Yatsen Holding Ltd ADRCOM98519410916,0327,456,739SH DFND26,961,1760495,563
Yatsen Holding Ltd ADRCOM9851941091626SH DFND362600
YelpCOM9858171059262SH DFND326200
Zai Lab ADRADR98887Q10489,1221,418,017SH DFND11,418,01700
Zai Lab ADRADR98887Q104170,4952,712,730SH DFND21,489,02201,223,708
Zai Lab ADRADR98887Q10437,434595,616SH DFND3284,0430311,573
Zai Lab ADRADR98887Q1044136,577SH DFND46,57700
Zai Lab ADRADR98887Q10425,511405,906SH SOLE0405,90600
Ziff Davis IncCOM48123V102653SH DFND35300
Zillow Group Inc Class ACL A98954M1011,92830,990SH DFND130,99000
Zillow Group Inc Class ACL A98954M10110,627170,804SH DFND259,2070111,597
Zillow Group Inc Class ACL A98954M1014,39570,635SH DFND370,63500
Zillow Group Inc Class ACL A98954M1015,65290,840SH SOLE090,84000
Zillow Group Inc Class CCL C CAP STK98954M200127,1051,990,676SH DFND11,990,67600
Zillow Group Inc Class CCL C CAP STK98954M200271,0244,244,705SH DFND23,348,0380896,667
Zillow Group Inc Class CCL C CAP STK98954M20058,764920,342SH DFND3639,8160280,526
Zillow Group Inc Class CCL C CAP STK98954M200200,9943,147,913SH SOLE02,229,7590918,154
Zoom Video Communications IncCL A98980L101277,0251,506,308SH DFND11,506,30800
Zoom Video Communications IncCL A98980L101732,6743,983,873SH DFND22,398,64001,585,233
Zoom Video Communications IncCL A98980L10174,738406,383SH DFND3352,054054,329
Zoom Video Communications IncCL A98980L101355,5991,933,550SH SOLE01,584,0740349,476
Zuora Inc Class ACOM CL A98983V10633,2271,778,724SH DFND11,778,72400
Zuora Inc Class ACOM CL A98983V10622,2551,191,371SH DFND2414,2850777,086
Zuora Inc Class ACOM CL A98983V10610,750575,481SH DFND3575,48100
Zuora Inc Class ACOM CL A98983V10614,597781,436SH SOLE0781,43600
Zymergen IncCOM98985X10018,8792,821,956SH SOLE02,821,95600
ZynexCOM98986M1034437SH DFND343700
Zynga IncCOM98986T108182,863SH DFND32,86300
dLocalCL AG2901810119,763553,728SH DFND1553,72800
dLocalCL AG290181018,789246,272SH DFND300246,272
dLocalCL AG290181015142SH DFND214200
iRobotCOM46272610013,748208,682SH DFND1208,68200
iRobotCOM46272610017,051258,818SH DFND2108,8770149,941
iRobotCOM46272610019,510296,148SH SOLE0296,14800
iRobotCOM4627261008,825133,957SH DFND3123,169010,788
iShares Physical Silver ETC (c)COM46428Q1093,638164,100SH DFND3164,10000
iShares Physical Silver ETC (c)COM46428Q10949,6802,240,756SH DFND12,240,75600
nCinoCOM63947U10713232SH DFND323200
nLIGHTCOM65487K10011468SH DFND346800