Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Illumina, Inc. Amended and Restated 2015 Stock and Incentive Plan of our reports dated February 17, 2023, with respect to the consolidated financial statements of Illumina, Inc. and the effectiveness of internal control over financial reporting of Illumina, Inc. included in its Annual Report (Form 10-K) for the year ended January 1, 2023, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
San Diego, California
March 1, 2023