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Palo Alto Investors

Filed: 16 May 22, 4:35pm

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABIOMED INCCOM003654100163,764494,397SH SOLE 494,39700
ACADIA PHARMACEUTICALS INCCOM00422510854,5392,251,834SH SOLE 2,251,83400
ALDEYRA THERAPEUTICS INCCOM01438T106715160,800SH SOLE 160,80000
ALIGN TECHNOLOGY INCCOM01625510119,31744,305SH SOLE 44,30500
ALIMERA SCIENCES INCCOM0162592021,125200,919SH SOLE 200,91900
ALKERMES PLCCOMG0176710517,722673,571SH SOLE 673,57100
AMICUS THERAPEUTICS INCCOM03152W10993,7899,903,761SH SOLE 9,903,76100
ANAPTYSBIO INCCOM03272410610,664431,024SH SOLE 431,02400
BIOGEN INCCOM09062X10376,023360,981SH SOLE 360,98100
BIOMARIN PHARMACEUTICAL INCCOM09061G101164,9642,139,614SH SOLE 2,139,61400
CLOVIS ONCOLOGY INCCOM1894641009,0374,473,967SH SOLE 4,473,96700
CYTOKINETICS INCCOM23282W6054,112111,717SH SOLE 111,71700
EHEALTH INCCOM28238P10920,5051,652,260SH SOLE 1,652,26000
EPIZYME INCCOM29428V1047,7916,774,541SH SOLE 6,774,54100
GOSSAMER BIO INCCOM38341P10215,2491,756,757SH SOLE 1,756,75700
GRITSTONE ONCOLOGY INCCOM39868T1059,6022,330,504SH SOLE 2,330,50400
INSMED INCCOM457669307138,2115,881,299SH SOLE 5,881,29900
KALEIDO BIOSCIENCES INCCOM483347100511309,692SH SOLE 309,69200
KARYOPHARM THERAPEUTICS INCCOM48576U10641,4315,621,533SH SOLE 5,621,53300
KEZAR LIFE SCIENCES INCCOM49372L10010,906656,200SH SOLE 656,20000
MAGENTA THERAPEUTICS INCCOM55910K1081,254432,300SH SOLE 432,30000
MARINUS PHARMACEUTICALS INCCOM56854Q20029331,330SH SOLE 31,33000
MIRUM PHARMACEUTICALS INCCOM6047491011,42564,700SH SOLE 64,70000
NOVAVAX INCCOM67000240192112,500SH SOLE 12,50000
PROTHENA CORP PLCCOMG7280010861,4921,681,477SH SOLE 1,681,47700
REVANCE THERAPEUTICS INCCOM76133010986,1064,415,689SH SOLE 4,415,68900
RIGEL PHARMACEUTICALS INCCOM7665596031,951652,395SH SOLE 652,39500
SAGE THERAPEUTICS INCCOM78667J10828,192851,719SH SOLE 851,71900
STAAR SURGICAL COCOM85231230590,8551,136,968SH SOLE 1,136,96800
SYNDAX PHARMACEUTICALS INCCOM87164F10510,647612,600SH SOLE 612,60000
TACTILE SYSTEMS TECHNOLOGY ICOM87357P10054627,100SH SOLE 27,10000
TRAVERE THERAPEUTICS INCCOM89422G1074,280166,069SH SOLE 166,06900
UNITED THERAPEUTICS CORPCOM91307C102117,169653,079SH SOLE 653,07900
UROGEN PHARMA LTDCOMM9608810521324,500SH SOLE 24,50000
VANDA PHARMACEUTICALS INCCOM92165910828,1752,491,200SH SOLE 2,491,20000