Cover Page
Cover Page - USD ($) | 12 Months Ended | ||
Dec. 31, 2022 | Feb. 17, 2023 | Jun. 30, 2022 | |
Cover [Abstract] | |||
Document Type | 10-K | ||
Document Annual Report | true | ||
Document Period End Date | Dec. 31, 2022 | ||
Current Fiscal Year End Date | --12-31 | ||
Document Transition Report | false | ||
Entity File Number | 001-36014 | ||
Entity Registrant Name | AGIOS PHARMACEUTICALS, INC. | ||
Entity Incorporation, State or Country Code | DE | ||
Entity Tax Identification Number | 26-0662915 | ||
Entity Address, Address Line One | 88 Sidney Street | ||
Entity Address, City or Town | Cambridge | ||
Entity Address, State or Province | MA | ||
Entity Address, Postal Zip Code | 02139 | ||
City Area Code | 617 | ||
Local Phone Number | 649-8600 | ||
Title of 12(b) Security | Common Stock, Par Value $0.001 per share | ||
Trading Symbol | AGIO | ||
Security Exchange Name | NASDAQ | ||
Entity Well-known Seasoned Issuer | Yes | ||
Entity Voluntary Filers | No | ||
Entity Current Reporting Status | Yes | ||
Entity Interactive Data Current | Yes | ||
Entity Filer Category | Large Accelerated Filer | ||
Entity Small Business | false | ||
Entity Emerging Growth Company | false | ||
ICFR Auditor Attestation Flag | true | ||
Entity Shell Company | false | ||
Entity Public Float | $ 1,200,277,504 | ||
Entity Common Stock, Shares Outstanding | 55,285,223 | ||
Documents Incorporated by Reference | Portions of the registrant’s definitive proxy statement for its 2023 Annual Meeting of Stockholders to be filed pursuant to Regulation 14A within 120 days of the end of the registrant’s fiscal year ended December 31, 2022 are incorporated by reference into Part III of this Annual Report on Form 10-K to the extent stated herein. | ||
Document Fiscal Year Focus | 2022 | ||
Document Fiscal Period Focus | FY | ||
Amendment Flag | false | ||
Entity Central Index Key | 0001439222 |
Audit Information
Audit Information | 12 Months Ended |
Dec. 31, 2022 | |
Auditor Information [Abstract] | |
Auditor Firm ID | 238 |
Auditor Name | PricewaterhouseCoopers LLP |
Auditor Location | Boston, Massachusetts |
Consolidated Balance Sheets
Consolidated Balance Sheets - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Current assets: | ||
Cash and cash equivalents | $ 139,259 | $ 203,126 |
Marketable securities | 643,860 | 816,892 |
Accounts receivable, net | 2,206 | 0 |
Other receivable | 0 | 4,378 |
Inventory | 8,492 | 0 |
Prepaid expenses and other current assets | 38,955 | 39,835 |
Total current assets | 832,772 | 1,064,231 |
Marketable securities | 313,874 | 266,375 |
Operating lease assets | 65,129 | 75,124 |
Property and equipment, net | 22,987 | 28,923 |
Financing lease assets | 0 | 183 |
Other non-current assets | 3,956 | 2,900 |
Total assets | 1,238,718 | 1,437,736 |
Current liabilities: | ||
Accounts payable | 18,616 | 16,700 |
Accrued expenses | 30,350 | 31,967 |
Operating lease liabilities | 13,663 | 10,828 |
Financing lease liabilities | 0 | 331 |
Total current liabilities | 62,629 | 59,826 |
Operating lease liabilities, net of current portion | 71,996 | 85,659 |
Financing lease liabilities, net of current portion | 0 | 276 |
Other non-current liabilities | 3,279 | 0 |
Total liabilities | 137,904 | 145,761 |
Commitments and contingent liabilities (Note 16) | ||
Stockholders’ equity: | ||
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2022 and 2021 | 0 | 0 |
Common stock, $0.001 par value; 125,000,000 shares authorized; 71,256,118 shares issued and 55,039,707 outstanding at December 31, 2022 and 70,550,631 shares issued and 54,334,220 outstanding at December 31, 2021 | 71 | 71 |
Additional paid-in capital | 2,386,325 | 2,334,348 |
Accumulated other comprehensive loss | (12,535) | (1,198) |
Accumulated deficit | (470,561) | (238,760) |
Treasury stock, at cost (16,216,411 shares at December 31, 2022 and December 31, 2021) | (802,486) | (802,486) |
Total stockholders’ equity | 1,100,814 | 1,291,975 |
Total liabilities and stockholders’ equity | $ 1,238,718 | $ 1,437,736 |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) - $ / shares | Dec. 31, 2022 | Dec. 31, 2021 |
Statement of Financial Position [Abstract] | ||
Preferred stock, par value (in usd per share) | $ 0.001 | $ 0.001 |
Preferred stock, shares authorized (in shares) | 25,000,000 | 25,000,000 |
Preferred stock, shares issued (in shares) | 0 | 0 |
Preferred stock, shares outstanding (in shares) | 0 | 0 |
Common stock, par value (in usd per share) | $ 0.001 | $ 0.001 |
Common stock, shares authorized (in shares) | 125,000,000 | 125,000,000 |
Common stock, shares issued (in shares) | 71,256,118 | 70,550,631 |
Common stock, shares outstanding (in shares) | 55,039,707 | 54,334,220 |
Treasury stock (in shares) | 16,216,411 |
Consolidated Statements of Oper
Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Total revenue | $ 14,240 | $ 0 | $ 0 |
Operating expenses | |||
Cost of sales | 1,704 | 0 | 0 |
Research and development | 279,910 | 256,973 | 220,811 |
Selling, general and administrative | 121,673 | 121,445 | 115,105 |
Total operating expenses | 403,287 | 378,418 | 335,916 |
Loss from operations | (389,047) | (378,418) | (335,916) |
Gain on sale of contingent payments | 127,853 | 0 | 0 |
Royalty income from gain on sale of oncology business | 9,851 | 6,639 | 0 |
Interest income, net | 12,793 | 836 | 6,611 |
Other income, net | 6,749 | 14,433 | 0 |
Net loss from continuing operations | (231,801) | (356,510) | (329,305) |
Net income from discontinued operations, net of tax | 0 | 1,961,225 | 1,935 |
Net (loss) income | $ (231,801) | $ 1,604,715 | $ (327,370) |
Net loss from continuing operations per share - basic (in usd per share) | $ (4.23) | $ (5.90) | $ (4.77) |
Net loss from continuing operations per share - diluted (in usd per share) | (4.23) | (5.90) | (4.77) |
Net income from discontinued operations per share - basic (in usd per share) | 0 | 32.45 | 0.03 |
Net income from discontinued operations per share - diluted (in usd per share) | 0 | 32.45 | 0.03 |
Net income (loss) per share – basic (in usd per share) | (4.23) | 26.55 | (4.74) |
Net income (loss) per share – diluted (in usd per share) | $ (4.23) | $ 26.55 | $ (4.74) |
Weighted-average number of common shares used in computing net loss per share – basic (in shares) | 54,789,435 | 60,447,346 | 68,997,879 |
Weighted-average number of common shares used in computing net loss per share – diluted (in shares) | 54,789,435 | 60,447,346 | 68,997,879 |
Product revenue, net | |||
Total revenue | $ 11,740 | $ 0 | $ 0 |
Milestone revenue | |||
Total revenue | $ 2,500 | $ 0 | $ 0 |
Consolidated Statements of Comp
Consolidated Statements of Comprehensive (Loss) Income - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Statement of Comprehensive Income [Abstract] | |||
Net (loss) income | $ (231,801) | $ 1,604,715 | $ (327,370) |
Other comprehensive (loss) income | |||
Unrealized loss on available-for-sale securities | (11,337) | (1,303) | (97) |
Comprehensive (loss) income | $ (243,138) | $ 1,603,412 | $ (327,467) |
Consolidated Statements of Stoc
Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Treasury |
Common stock, beginning balance (in shares) at Dec. 31, 2019 | 68,401,105 | |||||
Beginning balance at Dec. 31, 2019 | $ 640,528 | $ 68 | $ 2,156,363 | $ 202 | $ (1,516,105) | $ 0 |
Treasury stock, beginning balance (in shares) at Dec. 31, 2019 | 0 | |||||
Increase (Decrease) in Stockholders' Equity [Roll Forward] | ||||||
Unrealized gain (loss) on available-for-sale securities | (97) | (97) | ||||
Net (loss) income | (327,370) | (327,370) | ||||
Stock-based compensation expense | 61,602 | 61,602 | ||||
Issuance of common stock under stock incentive and employee stock purchase plans (in shares) | 892,815 | |||||
Issuance of common stock under stock incentive and employee stock purchase plans | 11,317 | $ 1 | 11,316 | |||
Disposition of oncology business | 13,520 | 13,520 | ||||
Common stock, ending balance (in shares) at Dec. 31, 2020 | 69,293,920 | |||||
Ending balance at Dec. 31, 2020 | 399,500 | $ 69 | 2,242,801 | 105 | (1,843,475) | $ 0 |
Treasury stock, ending balance (in shares) at Dec. 31, 2020 | 0 | |||||
Increase (Decrease) in Stockholders' Equity [Roll Forward] | ||||||
Unrealized gain (loss) on available-for-sale securities | (1,303) | (1,303) | ||||
Net (loss) income | 1,604,715 | 1,604,715 | ||||
Stock-based compensation expense | 53,508 | 53,508 | ||||
Issuance of common stock under stock incentive and employee stock purchase plans (in shares) | 1,256,711 | |||||
Issuance of common stock under stock incentive and employee stock purchase plans | 37,296 | $ 2 | 37,294 | |||
Repurchase of common stock (in shares) | (16,216,411) | |||||
Repurchase of common stock | (802,486) | $ (802,486) | ||||
Disposition of oncology business | $ 745 | 745 | ||||
Common stock, ending balance (in shares) at Dec. 31, 2021 | 54,334,220 | 70,550,631 | ||||
Ending balance at Dec. 31, 2021 | $ 1,291,975 | $ 71 | 2,334,348 | (1,198) | (238,760) | $ (802,486) |
Treasury stock, ending balance (in shares) at Dec. 31, 2021 | (16,216,411) | |||||
Increase (Decrease) in Stockholders' Equity [Roll Forward] | ||||||
Unrealized gain (loss) on available-for-sale securities | (11,337) | (11,337) | ||||
Net (loss) income | (231,801) | (231,801) | ||||
Stock-based compensation expense | $ 49,296 | 49,296 | ||||
Issuance of common stock under stock incentive and employee stock purchase plans (in shares) | 15,539 | 705,487 | ||||
Issuance of common stock under stock incentive and employee stock purchase plans | $ 2,681 | 2,681 | ||||
Common stock, ending balance (in shares) at Dec. 31, 2022 | 55,039,707 | 71,256,118 | ||||
Ending balance at Dec. 31, 2022 | $ 1,100,814 | $ 71 | $ 2,386,325 | $ (12,535) | $ (470,561) | $ (802,486) |
Treasury stock, ending balance (in shares) at Dec. 31, 2022 | (16,216,411) |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Operating activities | |||
Net (loss) income | $ (231,801) | $ 1,604,715 | $ (327,370) |
Less: Net income from discontinued operations | 0 | 1,961,225 | 1,935 |
Net loss from continuing operations | (231,801) | (356,510) | (329,305) |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Depreciation and amortization | 8,564 | 9,240 | 9,790 |
Stock-based compensation expense | 49,296 | 53,508 | 61,602 |
Net (accretion of discount) amortization of premium on marketable securities | (1,198) | 6,949 | 3,022 |
Gain on sale of contingent payments | (127,853) | 0 | 0 |
(Gain) loss on disposal of property and equipment | (48) | 12 | 0 |
Non-cash operating lease expense | 9,995 | 9,537 | 8,982 |
Changes in operating assets and liabilities: | |||
Accounts receivable, net | (2,206) | 0 | 0 |
Inventory | (8,492) | 0 | 0 |
Other receivables | 447 | (4,378) | 0 |
Prepaid expenses and other current and non-current assets | (176) | (26,846) | (3) |
Accounts payable | 3,436 | 1,863 | 3,330 |
Accrued expenses | (1,617) | 66 | 6,765 |
Operating lease liabilities | (10,828) | (7,527) | (8,127) |
Other liabilities | 3,003 | 0 | 0 |
Net cash used in operating activities | (309,478) | (314,086) | (243,944) |
Net cash used in operating activities - discontinued operations | 0 | (93,234) | (46,815) |
Net cash used in operating activities | (309,478) | (407,320) | (290,759) |
Investing activities | |||
Purchases of marketable securities | (1,030,781) | (1,378,221) | (557,030) |
Proceeds from maturities and sales of marketable securities | 1,146,175 | 829,804 | 647,685 |
Proceeds from sale of contingent payments | 131,784 | 0 | 0 |
Purchases of property and equipment | (4,881) | (5,741) | (14,106) |
Proceeds from sale of equipment | 964 | 0 | 0 |
Net cash provided by (used in) investing activities | 243,261 | (554,158) | 76,549 |
Net cash provided by (used in) investing activities - discontinued operations | 0 | 1,802,936 | (803) |
Net cash provided by investing activities | 243,261 | 1,248,778 | 75,746 |
Financing activities | |||
Payments on financing lease obligations | (331) | (578) | (336) |
Purchase of treasury stock | 0 | (802,486) | 0 |
Net proceeds from stock option exercises and employee stock purchase plan | 2,681 | 37,296 | 11,317 |
Net cash provided by (used in) financing activities | 2,350 | (765,768) | 10,981 |
Net cash provided by financing activities - discontinued operations | 0 | 0 | 250,537 |
Net cash provided by (used in) financing activities | 2,350 | (765,768) | 261,518 |
Net change in cash and cash equivalents | (63,867) | 75,690 | 46,505 |
Cash and cash equivalents at beginning of the period | 203,126 | 127,436 | 80,931 |
Cash and cash equivalents at end of the period | 139,259 | 203,126 | 127,436 |
Supplemental disclosure of non-cash investing and financing transactions: | |||
Additions to property and equipment in accounts payable and accrued expenses | 158 | 1,678 | 465 |
Cash taxes paid | 0 | 16,078 | 0 |
Financing lease liabilities arising from obtaining financing lease assets | $ 0 | $ 511 | $ 0 |
Nature of Business
Nature of Business | 12 Months Ended |
Dec. 31, 2022 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Nature of Business | Nature of Business References to Agios Throughout this Annual Report on Form 10-K, “the Company,” “we,” “us,” and “our,” and similar expressions, except where the context requires otherwise, refer to Agios Pharmaceuticals, Inc. and its consolidated subsidiaries, and “our board of directors” refers to the board of directors of Agios Pharmaceuticals, Inc. Overview We are a biopharmaceutical company committed to transforming patients’ lives through leadership in the field of cellular metabolism, with the goal of creating differentiated, small molecule medicines for rare diseases. With a history of focused study on cellular metabolism, we have a deep and mature understanding of this biology, which is involved in the healthy functioning of nearly every system in the body. We accelerate the impact of our portfolio by cultivating connections with patient communities, healthcare professionals, partners and colleagues to discover, develop and deliver potential therapies for rare diseases. We are located in Cambridge, Massachusetts. The lead product candidate in our portfolio, PYRUKYND® (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. In February 2022, the Food and Drug Administration, or FDA, approved PYRUKYND® for the treatment of hemolytic anemia in adults with PK deficiency in the United States. In November 2022, we received marketing authorization from the European Commission for PYRUKYND® for the treatment of PK deficiency in adult patients in the European Union, or EU. In December 2022, we received marketing authorization in Great Britain for PYRUKYND® for the treatment of PK deficiency in adult patients under the European Commission Decision Reliance Procedure. In addition, we are currently evaluating PYRUKYND® in clinical trials for the treatment of thalassemia, sickle cell disease, or SCD, and in pediatric patients with PK deficiency. We are also developing AG-946, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndrome, or LR MDS, and hemolytic anemias. In addition to the aforementioned clinical development programs, we continue to invest in our late-stage research program focused on advancing a phenylalanine hydroxylase, or PAH, stabilizer for the treatment of phenylketonuria, or PKU. We are subject to risks common to companies in our industry including, but not limited to, uncertainties relating to conducting clinical research and development, the manufacture and supply of products for clinical and commercial use, obtaining and maintaining regulatory approvals and pricing and reimbursement for our products, market acceptance, managing global growth and operating expenses, availability of additional capital, competition, obtaining and enforcing patents, stock price volatility, dependence on collaborative relationships and third-party service providers, dependence on key personnel, potential litigation, product liability claims and government investigations. Sale of our Oncology Business to Servier On March 31, 2021, we completed the sale of our oncology business to Servier Pharmaceuticals, LLC, or Servier, which represented a discontinued operation. The transaction included the sale of our oncology business, including TIBSOVO®, our clinical-stage product candidates vorasidenib, AG-270 and AG-636, and our oncology research programs for a payment of approximately $1.8 billion in cash at the closing, subject to certain adjustments, and a payment of $200.0 million in cash, if, prior to January 1, 2027, vorasidenib is granted new drug application, or NDA, approval from the FDA with an approved label that permits vorasidenib’s use as a single agent for the adjuvant treatment of patients with Grade 2 glioma that have an isocitrate dehydrogenase 1 or 2 mutation (and, to the extent required by such approval, the vorasidenib companion diagnostic test is granted an FDA premarket approval), as well as a royalty of 5% of U.S. net sales of TIBSOVO® from the close of the transaction through loss of exclusivity, and a royalty of 15% of U.S. net sales of vorasidenib from the first commercial sale of vorasidenib through loss of exclusivity. Servier also acquired our co-commercialization rights for Bristol Myers Squibb’s IDHIFA® and the right to receive a $25.0 million potential milestone payment under our prior collaboration agreement with Celgene Corporation, or Celgene, and following the sale Servier will conduct certain clinical development activities within the IDHIFA® development program. We recorded income from royalties of approximately $9.9 million and $6.6 million on U.S. net sales of TIBSOVO® by Servier in the royalty income from gain on sale of oncology business line item within the consolidated statements of operation s , for the years ended December 31, 2022 and December 31, 2021, respectively. Sale of Contingent Payments The consideration for the sale of our oncology business to Servier includes a royalty of 5% of U.S. net sales of TIBSOVO® from the close of the transaction through loss of exclusivity, referred to as contingent payments. We recognize the contingent payments in the royalty income from gain on sale of oncology business line item in our consolidated statement of operations in the period when realizable. On October 27, 2022, we sold our rights to future contingent payments to entities affiliated with Sagard Healthcare Partners, or Sagard, and recognized income of $127.9 million within the gain on sale of contingent payments line item in our consolidated statements of operations for the year ended December 31, 2022. We retained our rights to the potential milestone payment and royalties from Servier if vorasidenib is approved by the FDA. Reclassifications Certain amounts in prior periods have been reclassified to reflect the impact of the discontinued operations treatment of the oncology business in order to conform to the current period presentation. Liquidity On March 31, 2021, we completed the sale of our oncology business to Servier, and received approximately $1.8 billion in cash at closing. In connection with the sale, on March 25, 2021, we announced that our Board of Directors authorized the repurchase of up to $1.2 billion of our outstanding shares of common stock, or the Repurchase Program, using the proceeds from the sale of our oncology business to Servier. On March 31, 2021, in connection with the Repurchase Program, we entered into a definitive share repurchase agreement with Bristol-Myers Squibb Company, or BMS, to repurchase 7.1 million shares of our common stock held by certain subsidiaries of BMS for an aggregate purchase price of $344.5 million, or $48.38 per share. This repurchase was completed on April 5, 2021. Further, on April 2, 2021, in connection with the Repurchase Program, we entered into a Rule 10b5-1 repurchase plan pursuant to which we could repurchase up to $600.0 million of shares of our common stock. On October 5, 2021, we terminated our Rule 10b5-1 share repurchase program and on October 13, 2021 we entered into a Rule 10b-18 repurchase plan that allows us to conduct open market repurchases over time up to our remaining authorization under the Repurchase Program. We have not repurchased any shares of common stock in fiscal year 2022 and as of December 31, 2022 we have repurchased approximately 9.1 million shares of common stock for $458.0 million, or $50.35 per share, under the Rule 10b5-1 repurchase plan. As of December 31, 2022, we have not repurchased any shares under the Rule 10b-18 repurchase plan. In total, as of December 31, 2022, we repurchased 16.2 million shares of common stock for $802.5 million, or $49.49 per share, under the Repurchase Program. We have paused our share repurchases for the foreseeable future. On April 30, 2020, we entered into an at-the-market sales agreement, or the 2020 sales agreement, with Cowen & Company LLC, or Cowen, pursuant to which we may offer and sell shares of our common stock having an aggregate offering price of up to $250.0 million through Cowen pursuant to a universal shelf registration statement on Form S-3 filed with the SEC on April 30, 2020. As of December 31, 2022, $250.0 million in common stock remained available for future issuance under the 2020 sales agreement. On February 15, 2023, we delivered written notice to Cowen that we were terminating the 2020 sales agreement, effective on February 22, 2023. As of the termination of the 2020 sales agreement, we had not sold any shares of our common stock under the 2020 sales agreement. As of December 31, 2022, we had cash, cash equivalents and marketable securities of $1.1 billion. Although we have incurred recurring losses and expect to continue to incur losses for the foreseeable future, we expect our cash, cash equivalents and marketable securities to be sufficient to fund current operations for at least the next twelve months from the issuance of the financial statements. If we are unable to raise additional funds through equity or debt financings, we may be required to delay, limit, reduce or terminate product development or future commercialization efforts or grant rights to develop and market products or product candidates that we would otherwise prefer to develop and market ourselves. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 12 Months Ended |
Dec. 31, 2022 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | Summary of Significant Accounting Policies Principles of consolidation The consolidated financial statements include our accounts and the accounts of our wholly owned subsidiaries, Agios Securities Corporation, Agios International Sarl (GmbH), Agios Germany GmbH, Agios Netherlands B.V., Agios Italy S.R.L., Agios France SARL, and Agios Limited. All intercompany transactions have been eliminated in consolidation. The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles, or U.S. GAAP. Use of estimates The preparation of our consolidated financial statements requires us to make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, equity, revenues and expenses and related disclosure of contingent assets and liabilities. On an ongoing basis we evaluate our estimates, judgments and methodologies. We base our estimates on historical experience and on various other assumptions that we believe are reasonable, the results of which form the basis for making judgments about the carrying values of assets, liabilities and equity and the amount of revenues and expenses. The full extent to which the COVID-19 pandemic will directly or indirectly impact our business, results of operations and financial condition, including expenses, reserves and allowances, clinical trials, research and development costs and employee-related amounts, will depend on future developments that are highly uncertain, including as a result of new information that may emerge concerning COVID-19 and any variant strains of the virus and the actions taken to contain the pandemic or treat COVID-19, as well as the economic impact on local, regional, national and international customers and markets. We have made estimates of the impact of COVID-19 within our financial statements and there may be changes to those estimates in future periods. Actual results may differ from these estimates. Cash and cash equivalents We consider highly liquid investments with a maturity of three months or less when purchased to be cash equivalents. Cash equivalents are stated at fair value. Accounts receivable, net Our trade accounts receivable arise from product sales and represent amounts due from specialty distributors and specialty pharmacy providers in the U.S. We monitor the financial performance and creditworthiness of our customers so that we can properly assess and respond to changes in their credit profile. We reserve against these receivables for estimated losses that may arise from a customer’s inability to pay. Amounts determined to be uncollectible are charged or written-off against the reserve. Inventory Inventory is stated at the lower of cost or estimated net realizable value on a first-in, first-out basis. Prior to the regulatory approval of our product candidates, we incur expenses for the manufacture of drug product that could potentially be available to support the commercial launch of those products. Until the date at which regulatory approval has been received or is otherwise considered probable, we record all such costs as research and development expenses. Upon approval of our wholly owned product, PYRUKYND®, by the FDA on February 17, 2022 for the treatment of hemolytic anemia in adults with PK deficiency in the United States, we began to capitalize inventories of PYRUKYND®. Revenue recognition Under Accounting Standards Codification 606, Revenue from Contracts with Customers , or ASC 606, revenue is recognized when the customer obtains control of promised goods or services, in an amount that reflects the consideration that we expect to receive in exchange for those goods or services. To determine revenue recognition for arrangements that have been determined to be within the scope of ASC 606, we perform the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) we satisfy a performance obligation. We only apply the five-step model to contracts when it is probable that we will collect the consideration we are entitled to in exchange for the goods or services we transfer to the customer. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Once the contract is determined to be within the scope of ASC 606, we assess the goods or services promised within each contract and determine those that are performance obligations, and assess whether each promised good or service is distinct. We will then recognize as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Product Revenue We generate product revenue from sales of PYRUKYND® to a limited number of specialty distributors and specialty pharmacy providers, or collectively, the Customers. These Customers subsequently resell PYRUKYND® to pharmacies or dispense directly to patients. In addition to distribution agreements with Customers, we enter into arrangements with healthcare providers and payors that provide for government-mandated and/or privately-negotiated rebates, chargebacks and discounts with respect to the purchase of PYRUKYND®. The performance obligation related to the sale of PYRUKYND® is satisfied and revenue is recognized when the Customer obtains control of the product, which occurs at a point in time, typically upon delivery to the Customer. Revenues from product sales are recorded at the net sales price, or transaction price, which includes estimates of variable consideration for which reserves are established and result from contractual adjustments, government rebates, returns and other allowances that are offered within the contracts with our Customers, healthcare providers, payors and other indirect customers relating to the sale of our products. Contractual Adjustments . We generally provide Customers with discounts, including prompt pay discounts, and allowances that are explicitly stated in the contracts and are recorded as a reduction of revenue in the period the related product revenue is recognized. In addition, we receive sales order management, data and distribution services from certain Customers. Chargebacks and discounts represent the estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices charged to Customers who directly purchase the product from us. Customers charge us for the difference between what they pay for the product and the ultimate selling price to the qualified healthcare providers. These reserves are estimated using the expected value method, based upon a range of possible outcomes that are probability-weighted for the estimated channel mix and are established in the same period that the related revenue is recognized, resulting in a reduction of product revenue. Government Rebates . Government rebates include Medicare, TriCare, and Medicaid rebates, which we estimate using the expected value method, based upon a range of possible outcomes that are probability-weighted for the estimated payor mix. These reserves are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue. For Medicare, we also estimate the number of patients in the prescription drug coverage gap for whom we will owe an additional liability under the Medicare Part D program. Returns . We estimate the amount of product sales that may be returned by Customers and record this estimate as a reduction of revenue in the period the related product revenue is recognized. We currently estimate product return liabilities using the expected value method, based on available industry data, including our visibility into the inventory remaining in the distribution channel. Cost of sales Cost of sales consists primarily of manufacturing costs for sales of PYRUKYND®. Based on our policy to expense costs associated with the manufacturing of our products prior to regulatory approval, certain of the manufacturing costs associated with product shipments of PYRUKYND® recorded during the twelve months ended December 31, 2022 were expensed prior to February 17, 2022 and, therefore, are not included in costs of sales during the twelve months ended December 31, 2022. Marketable securities Marketable securities at December 31, 2022 and 2021 consisted of investments in U.S. Treasuries, government securities and corporate debt securities. We determine the appropriate classification of the securities at the time they are acquired and evaluate the appropriateness of such classifications at each balance sheet date. We classify our marketable securities as available-for-sale pursuant to ASC 320, Investments – Debt and Equity Securities . Marketable securities are recorded at fair value. Unrealized gains and losses are included as a component of accumulated other comprehensive (loss) income in the consolidated balance sheets and statements of stockholders’ equity and a component of total comprehensive (loss) income in the consolidated statements of comprehensive (loss) income, until realized. Realized gains and losses are included in investment income on a specific-identification basis. At December 31, 2022 and 2021, we held both current and non-current investments. Investments classified as current have maturities of less than one year. Investments classified as non-current are those that: (i) have a maturity of one We review marketable securities for impairment whenever the fair value of a marketable security is less than the amortized cost and evidence indicates that a marketable security’s carrying amount is not recoverable. Unrealized losses are evaluated for impairment under ASC 326, Financial Instruments - Credit Losses , to determine if the impairment is credit-related or noncredit-related. Credit-related impairment is recognized as an allowance on the balance sheet with a corresponding adjustment to earnings, and noncredit-related impairment is recognized in other comprehensive (loss) income, net of taxes. Evidence considered in this assessment includes reasons for the impairment, compliance with our investment policy, the severity of the impairment, collectability of the security, and any adverse conditions specifically related to the security, an industry, or geographic area. Fair value measurements We record cash equivalents and marketable securities at fair value. ASC 820, Fair Value Measurements and Disclosures , establishes a fair value hierarchy for those instruments measured at fair value that distinguishes between assumptions based on market data (observable inputs) and our own assumptions (unobservable inputs). The hierarchy consists of three levels: Level 1 – Unadjusted quoted prices in active markets for identical assets or liabilities. Level 2 – Quoted prices for similar assets and liabilities in active markets, quoted prices in markets that are not active, or inputs which are observable, either directly or indirectly, for substantially the full term of the asset or liability. Level 3 – Unobservable inputs that reflect our own assumptions about the assumptions market participants would use in pricing the asset or liability in which there is little, if any, market activity for the asset or liability at the measurement date. Our financial assets, which include cash equivalents and marketable securities, have been initially valued at the transaction price, and subsequently revalued at the end of each reporting period, utilizing third-party pricing services or other observable market data. The pricing services utilize industry standard valuation models, including both income and market based approaches, and observable market inputs to determine value. After completing our validation procedures, we did not adjust or override any fair value measurements provided by the pricing services as of December 31, 2022 or 2021. Fair value information for these assets, including their classification in the fair value hierarchy is included in Note 3 , Fair Value Measurements . There have been no changes to the valuation methods during the years ended December 31, 2022 and 2021. We evaluate transfers between levels at the end of each reporting period. The carrying amounts of other receivables, prepaid expenses and other current assets, accounts payable, and accrued expenses approximate their fair values due to their short-term maturities. Concentrations of credit risk Financial instruments which potentially subject us to credit risk consist primarily of cash, cash equivalents, and marketable securities. We hold these investments in highly rated financial institutions, and, by policy, limit the amounts of credit exposure to any one financial institution. These amounts at times may exceed federally insured limits. We have not experienced any credit losses in such accounts and do not believe we are exposed to any significant credit risk on these funds. We have no off-balance sheet concentrations of credit risk, such as foreign currency exchange contracts, option contracts, or other hedging arrangements. Property and equipment Property and equipment consist of laboratory equipment, computer equipment and software, leasehold improvements, furniture and fixtures, and office equipment. Costs of major additions and betterment are capitalized; maintenance and repairs, which do not improve or extend the life of the respective assets, are charged to expense as incurred. Upon retirement or sale, the cost of the disposed asset and the related accumulated depreciation are removed from the accounts and the resulting gain or loss is recognized. Property and equipment is stated at cost, and depreciated using the straight-line method over the estimated useful lives of the respective assets: Years Laboratory equipment 5 Computer equipment and software 3 Furniture and fixtures 5 Office equipment 5 Leasehold improvements are amortized over the lesser of the remaining lease term or the estimated useful life of the improvement. Impairment of long-lived assets We periodically evaluate our long-lived assets for potential impairment in accordance with ASC 360, Property, Plant and Equipment . Potential impairment is assessed when there is evidence that events or changes in circumstances indicate that the carrying amount of an asset may not be recovered. Recoverability of these assets is assessed based on the undiscounted expected future cash flows from the assets, considering a number of factors, including past operating results, budgets and economic projections, market trends and product development cycles. If impairments are identified, assets are written down to their estimated fair value. We did not recognize any impairment charges through December 31, 2022. Leases We determine if an arrangement is a lease at inception. An arrangement is determined to contain a lease if the contract conveys the right to control the use of an identified property or equipment for a period of time in exchange for consideration. If we can benefit from the various underlying assets of a lease on their own or together with other resources that are readily available, or if the various underlying assets are neither highly dependent on nor highly interrelated with other underlying assets in the arrangement, they are considered to be a separate lease component. In the event multiple underlying assets are identified, the lease consideration is allocated to the various components based on each of the component’s relative fair value. Operating lease assets represent our right to use an underlying asset for the lease term and operating lease liabilities represent our obligation to make lease payments arising from the leasing arrangement. Operating lease assets and operating lease liabilities are recognized at commencement date based on the present value of lease payments over the lease term. As most of our leases do not provide an implicit rate, in determining the operating lease liabilities we use an estimate of our incremental borrowing rate. The incremental borrowing rate is determined using two alternative credit scoring models to estimate our credit rating, adjusted for collateralization. The calculation of the operating lease assets includes any lease payments made and excludes any lease incentives. Our lease terms may include options to extend or terminate the lease when it is reasonably certain that we will exercise that option. For operating leases, we record operating lease assets and lease liabilities in our consolidated balance sheets. Lease expense for lease payments is recognized on a straight-line basis over the lease term. Short-term leases, or leases that have a lease term of 12 months or less at commencement date, are excluded from this treatment and are recognized on a straight-line basis over the term of the lease. We have not entered into any material short-term leases or financing leases as of December 31, 2022. Research and development costs Research and development costs, including those accrued as of each balance sheet date, are expensed as incurred. These costs include salaries and personnel-related costs, consulting fees, fees paid for contract research services, fees paid to contract research organizations, or CROs, and other third parties in connection with clinical trials and preclinical development activities, fees paid to investigative sites in connection with clinical studies, the costs associated with the product manufacturing, development, and distribution of clinical supplies, the costs of laboratory equipment and facilities, and other external costs. Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are deferred and capitalized. Additionally, there may be instances in which payments made to our vendors will exceed the level of services provided, and result in a prepayment of the research and development expense. The capitalized amounts are expensed as the related goods are delivered or the services are performed. We estimate the time period over which services will be performed and the level of effort to be expended in each period. If the actual timing of the performance of services or the level of effort varies from our estimate, we adjust the accrual or prepaid accordingly. Stock-based compensation We account for stock-based compensation awards in accordance with ASC 718, Compensation –Stock Compensation , or ASC 718. For stock-based awards granted to employees, non-employees and members of the board of directors for their services and for participation in our employee stock purchase plan, we estimate the grant date fair value of each option award using the Black-Scholes option-pricing model. The use of the Black-Scholes option-pricing model requires us to make assumptions with respect to the expected term of the option, the expected volatility of the common stock consistent with the expected life of the option, risk-free interest rates and expected dividend yields of the common stock. For awards subject to service-based vesting conditions, we recognize stock-based compensation expense equal to the grant date fair value of stock options on a straight-line basis over the requisite service period. For awards subject to both performance and service-based vesting conditions, we recognize stock-based compensation expense over the remaining service period if the performance condition is considered probable of achievement using management’s best estimates. Income taxes Income taxes are recorded in accordance with ASC 740, Accounting for Income Taxes , or ASC 740, which provides for deferred taxes using an asset and liability approach. We recognize deferred tax assets and liabilities for the expected future tax consequences of events that have been included in our financial statements or tax returns. We determine our deferred tax assets and liabilities based on differences between the financial reporting and tax bases of assets and liabilities, which are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. Valuation allowances are provided, if based upon the weight of available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. We also account for uncertain tax positions in accordance with the provisions of ASC 740. When uncertain tax positions exist, we recognize the tax benefit of tax positions to the extent that the benefit will more likely than not be realized. The determination as to whether the tax benefit will more likely than not be realized is based upon the technical merits of the tax position as well as consideration of the available facts and circumstances. Comprehensive income (loss) Comprehensive income (loss) is defined as the change in equity of a business enterprise during a period from transactions, and other events and circumstances, and currently consists of net loss and unrealized gains and losses on available-for-sale securities. Accumulated other comprehensive (loss) income consists entirely of unrealized gains and losses from available-for-sale securities as of December 31, 2022 and 2021. Net income (loss) per share Basic net income (loss) per share is calculated by dividing net income (loss) by the weighted-average shares outstanding during the period, without consideration for common stock equivalents. Diluted net income (loss) per share is calculated by adjusting weighted-average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, determined using the treasury-stock method. For purposes of the dilutive net income (loss) per share calculation, stock options, restricted stock units, or RSUs, performance-based stock units, or PSUs, and market-based stock units, or MSUs, for which the performance and market vesting conditions, respectively, have been deemed probable, and employee stock purchase plan shares are considered to be common stock equivalents but are excluded from the calculation of diluted net income (loss) per share as their effect would be anti-dilutive. We utilize the control number concept in the computation of diluted earnings per share to determine whether potential common stock equivalents are dilutive. The control number used is loss from continuing operations. The control number concept requires that the same number of potentially dilutive securities applied in computing diluted earnings per share from continuing operations be applied to all other categories of income or loss, regardless of their anti-dilutive effect on such categories. Since we had a net loss from continuing operations for all periods presented, no dilutive effect has been recognized in the calculation of income (loss) from discontinued operations per share or net income (loss) per share. Segment and geographic information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker or decision-making group in making decisions on how to allocate resources and assess performance. Our chief operating decision maker is the chief executive officer. Our chief operating decision maker and we view our operations and manage our business as one operating segment. Discontinued operations We accounted for the sale of our oncology business in accordance with ASC 205, Discontinued Operations and Accounting Standards Update, or ASU, No. 2014-08, Reporting of Discontinued Operations and Disclosures of Disposals of Components of an Entity . We followed the held-for-sale criteria as defined in ASC 360, Property, Plant and Equipment, and ASC 205. ASC 205 requires that a component of an entity that has been disposed of or is classified as held for sale and has operations and cash flows that can be clearly distinguished from the rest of the entity be reported as assets held for sale and discontinued operations. In the period a component of an entity has been disposed of or classified as held for sale, the results of operations for the periods presented are reclassified into separate line items in the consolidated statements of operations. Assets and liabilities are also reclassified into separate line items on the related consolidated balance sheets for the periods presented. The statements of cash flows for the periods presented are also reclassified to reflect the results of discontinued operations as separate line items. ASU 2014-08 requires that only a disposal of a component of an entity, or a group of components of an entity, that represents a strategic shift that has, or will have, a major effect on the reporting entity’s operations and financial results be reported in the financial statements as discontinued operations. ASU 2014-08 also provides guidance on the financial statement presentations and disclosures of discontinued operations. Due to the sale of the oncology business during the first quarter of 2021, in accordance with ASC 205, we have classified the results of the oncology business as discontinued operations in our consolidated statements of operations and cash flows for all periods presented, and refer to Note 15 , Discontinued Operations . All assets and liabilities associated with our oncology business were therefore classified as assets and liabilities of discontinued operations in our consolidated balance sheets for the periods presented. All amounts included in the notes to the consolidated financial statements relate to continuing operations unless otherwise noted. Treasury stock Treasury stock purchases are accounted for under the cost method whereby the entire cost of the acquired stock is recorded as treasury stock. Recent accounting pronouncements In June 2016, the Financial Accounting Standards Board, or FASB, issued ASU 2016-13, Financial Instruments - Credit Losses (Topic 326) , which introduces new guidance for the accounting for credit losses on instruments within its scope. The new guidance introduces an approach based on expected losses to estimate credit losses on certain types of financial instruments. Credit losses relating to available-for-sale debt securities will also be recorded through an allowance for credit losses rather than as a reduction in the amortized cost basis of the securities. The guidance is effective for fiscal years beginning after December 31, 2019, including interim periods within those years. The Company adopted this amendment as of January 1, 2020, which eliminated the concept of other-than-temporary impairments and required credit losses on debt securities to be recorded through an allowance for credit losses instead of as a reduction in the amortized cost basis of the securities. Application of the amendments is through a cumulative-effect adjustment to retained earnings as of the effective date. There was no material impact to the Company’s consolidated financial position, results of operation, or cash flows. Other accounting standards that have been issued by the FASB or other standards-setting bodies that do not require adoption until a future date are not expected to have a material impact on our financial statements upon adoption. Subsequent events We considered events or transactions occurring after the balance sheet date, but prior to the issuance of the consolidated financial statements, for potential recognition or disclosure in our consolidated financial statements. All significant subsequent events have been properly disclosed in the consolidated financial statements. |
Fair Value Measurements
Fair Value Measurements | 12 Months Ended |
Dec. 31, 2022 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | Fair Value Measurements The following table summarizes our cash equivalents and marketable securities measured at fair value and by level (as described in Note 2. Summary of Significant Accounting Policies ) on a recurring basis as of December 31, 2022: (In thousands) Level 1 Level 2 Level 3 Total Cash equivalents $ 37,093 $ 50,909 $ — $ 88,002 Total cash equivalents 37,093 50,909 — 88,002 Marketable securities: U.S. Treasuries — 84,596 — 84,596 Government securities — 331,443 — 331,443 Corporate debt securities — 541,695 — 541,695 Total marketable securities — 957,734 — 957,734 Total cash equivalents and marketable securities $ 37,093 $ 1,008,643 $ — $ 1,045,736 There were no transfers between Level 1 and Level 2 and we had no financial assets or liabilities that were classified as Level 3 at any point during the year ended December 31, 2022. |
Marketable Securities
Marketable Securities | 12 Months Ended |
Dec. 31, 2022 | |
Investments, Debt and Equity Securities [Abstract] | |
Marketable Securities | Marketable Securities Marketable securities at December 31, 2022 consisted of the following: (In thousands) Amortized Unrealized Unrealized Fair Current: U.S. Treasuries $ 68,175 $ 3 $ (811) $ 67,367 Government securities 220,901 8 (5,289) 215,620 Corporate debt securities 363,263 1 (2,391) 360,873 Total Current 652,339 12 (8,491) 643,860 Non-current: U.S. Treasuries 17,418 4 (193) 17,229 Government securities 117,475 7 (1,659) 115,823 Corporate debt securities 183,037 76 (2,291) 180,822 Total Non-current 317,930 87 (4,143) 313,874 Total marketable securities $ 970,269 $ 99 $ (12,634) $ 957,734 Marketable securities at December 31, 2021 consisted of the following: (In thousands) Amortized Cost Unrealized Gains Unrealized Losses Fair Value Current: U.S. Treasuries $ 269,109 $ — $ (36) $ 269,073 Government securities 17,764 1 (10) 17,755 Corporate debt securities 530,490 3 (429) 530,064 Total Current 817,363 4 (475) 816,892 Non-current: U.S. Treasuries 40,607 — (23) 40,584 Government securities 148,820 — (470) 148,350 Corporate debt securities 77,675 — (234) 77,441 Total Non-current 267,102 — (727) 266,375 Total marketable securities $ 1,084,465 $ 4 $ (1,202) $ 1,083,267 There were no material realized gains or losses on marketable securities for the years ended December 31, 2022 and 2021. At December 31, 2022 and 2021, we held 259 and 294 debt securities, respectively, that were in an unrealized loss position for less than one year. We did not record an allowance for credit losses as of December 31, 2022 and December 31, 2021 related to these securities. The aggregate fair value of debt securities in an unrealized loss position at December 31, 2022 and 2021 was $868.2 million and $950.5 million, respectively. There were no individual securities that were in a significant unrealized loss position as of December 31, 2022 and 2021. We regularly review the securities in an unrealized loss position and evaluate the current expected credit loss by considering factors such as historical experience, market data, issuer-specific factors, and current economic conditions. We do not consider these marketable securities to be impaired as of December 31, 2022 and 2021. |
Inventory
Inventory | 12 Months Ended |
Dec. 31, 2022 | |
Inventory Disclosure [Abstract] | |
Inventory | Inventory Inventory, which consists of commercial supply of PYRUKYND®, consisted of the following: (In thousands) December 31, December 31, Raw materials $ — $ — Work-in-process 7,550 — Finished goods 942 — Total inventory $ 8,492 $ — |
Leases
Leases | 12 Months Ended |
Dec. 31, 2022 | |
Leases [Abstract] | |
Leases | Leases Our building leases are comprised of office and laboratory space under non-cancelable operating leases. These lease agreements have remaining lease terms of five years and contain various clauses for renewal at our option. The renewal options were not included in the calculation of the operating lease assets and the operating lease liabilities as the renewal options are not reasonably certain of being exercised. The lease agreements do not contain residual value guarantees. On April 11, 2019, we entered into an agreement to lease approximately 13,000 square feet of office space located at 38 Sidney Street, Cambridge, Massachusetts, or the 38 Sidney Lease, with Thirty-Eight Sidney Street, LLC. The initial term of the 38 Sidney Lease commenced on May 1, 2019 and expires on February 29, 2028. At the end of the lease term, we have the option to extend the 38 Sidney Lease for two consecutive terms of five years at fair market rent at the time of the extension. The 38 Sidney Lease provides us with the right to lease additional space within the 38 Sidney Street building and also includes rent escalation clauses and a tenant improvement allowance of $1.0 million. In connection with the 38 Sidney Lease, we also amended our existing building leases at 88 Sidney Street, Cambridge, Massachusetts and at 64 Sidney Street, Cambridge, Massachusetts to extend the initial terms of those leases by approximately three years through February 29, 2028. The amendments also provide us with the right to lease additional space at the 64 Sidney Street building. Our existing extension options for the 88 Sidney Street building and 64 Sidney Street building continue as set forth in the existing leases for those buildings. The components of lease expense and other information related to leases were as follows: (In millions) 2022 2021 2020 Operating lease costs $ 15,227 $ 15,229 $ 15,241 Cash paid for amounts included in the measurement of operating lease liabilities 17,035 14,411 14,424 We have not entered into any material short-term leases or financing leases as of December 31, 2022. In arriving at the operating lease liabilities as of December 31, 2022, we applied the weighted-average incremental borrowing rate of 5.7% from inception over a weighted-average remaining lease term of 5.2 years. In arriving at the operating lease liabilities as of December 31, 2021, we applied the weighted-average incremental borrowing rate of 5.7% over a weighted-average remaining lease term of 6.2 years. As of December 31, 2022, undiscounted minimum rental commitments under non-cancelable leases, for each of the next five years and total thereafter, were as follows: (In thousands) 2023 $ 16,651 2024 18,660 2025 19,507 2026 20,151 2027 20,755 Thereafter 3,479 Undiscounted minimum rental commitments 99,203 Interest (13,544) Total operating lease liabilities $ 85,659 We provided our landlord a standby letter of credit of $2.9 million as security for our leases. We are not required to maintain any cash collateral for the standby letter of credit. In August 2021, we entered into a long-term sublease agreement for 13,000 square feet of the office space at 38 Sidney Street, Cambridge, Massachusetts, with the term of the lease running through December 2024. In April 2022, we entered into a long-term sublease agreement for 27,000 square feet of the office space at 64 Sidney Street, Cambridge, Massachusetts, with the term of the lease running through April 2025. We recorded operating sublease income of $4.1 million and $0.5 million for the years ended December 31, 2022 and December 31, 2021, respectively, in other income, net in the consolidated statements of operations. We received a security deposit from our sublessee of approximately $1.1 million which is recorded within other non-current assets on our consolidated balance sheet. As of December 31, 2022, the future minimum lease payments to be received under the long-term sublease agreements were as follows: (In thousands) 2023 4,329 2024 4,459 2025 1,101 Total $ 9,889 |
Accrued Expenses
Accrued Expenses | 12 Months Ended |
Dec. 31, 2022 | |
Payables and Accruals [Abstract] | |
Accrued Expenses | Accrued Expenses Accrued expenses consisted of the following at December 31: (In thousands) 2022 2021 Accrued compensation $ 18,105 $ 19,818 Accrued research and development costs 8,425 5,980 Accrued professional fees 2,435 2,335 Accrued other 1,385 3,834 Total accrued expenses $ 30,350 $ 31,967 |
Product Revenue
Product Revenue | 12 Months Ended |
Dec. 31, 2022 | |
Revenue from Contract with Customer [Abstract] | |
Product Revenue | Product Revenue We sell PYRUKYND®, our wholly owned product, to the Customers. The Customers subsequently resell PYRUKYND® to pharmacies or dispense directly to patients. In addition to distribution agreements with Customers, we enter into arrangements with healthcare providers and payors that provide for government-mandated and/or privately-negotiated rebates, chargebacks and discounts with respect to the purchase of PYRUKYND®. The performance obligation related to the sale of PYRUKYND® is satisfied and revenue is recognized when the Customer obtains control of the product, which occurs at a point in time, typically upon delivery to the Customer. Product revenue, net, was as follows for the years ended December 31: (In thousands) 2022 2021 2020 Product revenue, net $ 11,740 $ — $ — Reserves for Variable Consideration Revenues from product sales are recorded at the net sales price, or transaction price, which includes estimates of variable consideration for which reserves are established and result from contractual adjustments, government rebates, returns and other allowances that are offered within the contracts with our Customers, healthcare providers, payors and other indirect customers relating to the sale of our products. The following table summarizes balances and activity in each of the product revenue allowance and reserve categories for the year ended December 31, 2022: (In thousands) Contractual Adjustments Government Rebates Returns Total Balance at December 31, 2021 $ — $ — $ — $ — Current provisions relating to sales in the current year 497 912 133 1,542 Adjustments relating to prior years — — — — Payments/returns relating to sales in the current year (432) (339) (771) Payments/returns relating to sales in the prior years — — — — Balance at December 31, 2022 $ 65 $ 573 $ 133 $ 771 There were no balances or activity related to product revenue allowance and reserve categories for the year ended December 31, 2021. Total revenue-related reserves above, included in our consolidated balance sheets, are summarized as follows: (In thousands) December 31, 2022 December 31, 2021 Reduction of accounts receivable $ 60 $ — Component of accrued expenses 711 — Total revenue-related reserves $ 771 $ — The following table presents changes in our contract assets during the year ended December 31, 2022: (In thousands) December 31, 2021 Additions Deductions December 31, 2022 Contract assets (1) Accounts receivable, net $ — $ 13,283 $ (11,077) $ 2,206 (1) Additions to contract assets relate to amounts billed to Customers for product sales, and deductions to contract assets primarily relate to collection of receivables during the reporting period. There were no balances or activity related to contract assets for the year ended December 31, 2021. |
Share-Based Payments
Share-Based Payments | 12 Months Ended |
Dec. 31, 2022 | |
Share-Based Payment Arrangement [Abstract] | |
Share-Based Payments | Share-Based Payments Stock incentive plans In June 2013, our Board of Directors adopted and, in July 2013 our stockholders approved, the 2013 Stock Incentive Plan, or the 2013 Plan. The 2013 Plan became effective upon the closing of our initial public offering and provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock awards, RSUs, PSUs, and other stock-based awards to employees, non-employees and non-employee directors. Following the adoption of the 2013 Plan, we granted no further stock options or other awards under the 2007 Stock Incentive Plan, or the 2007 Plan. Any options or awards outstanding under the 2007 Plan at the time of adoption of the 2013 Plan remain outstanding and effective. As of December 31, 2022, the total number of shares reserved under the 2007 Plan and the 2013 Plan was 12,821,789, and we had 5,458,366 shares available for future issuance under the 2013 Plan. The 2013 Plan provides for an annual increase, to be added on the first day of each fiscal year, beginning with the fiscal year ending December 31, 2014 and continuing until the expiration of the 2013 Plan, equal to the lesser of (i) 2,000,000 shares of common stock, (ii) 4% of the outstanding shares of common stock on such date or (iii) an amount determined by our Board of Directors. On January 1, 2023, the annual increase for the 2013 Plan resulted in an additional 2,000,000 shares authorized for issuance. Stock options The following table summarizes the stock option activity of all stock incentive plans for the year ended December 31, 2022: Number of Stock Options Weighted- Average Exercise Price Weighted- Average Remaining Contractual Term (in years) Aggregate Intrinsic Value (in thousands) Outstanding at December 31, 2021 4,798,826 $ 58.51 6.24 $ 4,697 Granted 1,850,093 28.89 Exercised (15,539) 11.50 Forfeited/Expired (860,816) 60.91 Outstanding at December 31, 2022 5,772,564 $ 48.81 6.50 $ 5,362 Exercisable at December 31, 2022 3,497,660 $ 58.24 4.84 $ 3,141 Vested and expected to vest at December 31, 2022 5,772,564 $ 48.81 6.50 $ 5,362 The weighted-average grant date fair value of options granted was $15.64, $31.20 and $32.10 during the years ended December 31, 2022, 2021 and 2020, respectively. The total intrinsic value of options exercised was $0.3 million, $8.5 million and $10.4 million during the years ended December 31, 2022, 2021 and 2020, respectively. At December 31, 2022, the total unrecognized compensation expense related to unvested stock option awards was $38.1 million, which we expect to recognize over a weighted-average period of approximately 2.71 years. Restricted stock units Upon vesting, each RSU entitles the holder to receive a specified number of shares of our common stock. The following table presents RSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 1,002,924 $ 51.51 Granted 869,766 31.16 Vested (531,304) 50.16 Forfeited (223,465) 41.84 Unvested shares at December 31, 2022 1,117,921 $ 38.30 As of December 31, 2022, there was approximately $25.6 million of total unrecognized compensation expense related to RSUs, which we expect to be recognized over a weighted-average period of 1.76 years. Performance-based stock units At the achievement of the performance-based and service-based vesting criteria, each PSU entitles the holder to receive a specified number of shares of our common stock. The following table presents PSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 234,059 $ 54.28 Granted 337,243 30.33 Vested (53,777) 54.28 Forfeited (47,190) 49.06 Expired (40,092) 56.52 Unvested shares at December 31, 2022 430,243 $ 35.87 Stock-based compensation expense associated with these PSUs is recognized if the underlying performance condition is considered probable of achievement using our management’s best estimates. As of December 31, 2022, there was no unrecognized compensation expense related to PSUs with performance-based vesting criteria that are considered probable of achievement that we expect to recognize. There is $15.4 million of total unrecognized compensation expense related to PSUs with performance-based vesting criteria that are considered not probable of achievement. Market-based stock units We have issued certain equity awards that contain market based vesting conditions, in which shares of stock are earned at vesting based on stock price performance. The fair value of MSUs are estimated using a Monte Carlo simulation model. Assumptions and estimates utilized in the model include the risk-free interest rate, dividend yield, expected stock volatility and the estimated period to achievement of the market condition. The following table presents MSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 42,695 $ 41.50 Granted — — Unvested shares at December 31, 2022 42,695 $ 41.50 As of December 31, 2022, there was no remaining unrecognized compensation expense related to MSUs. 2013 Employee Stock Purchase Plan In June 2013, our Board of Directors adopted, and in July 2013 our stockholders approved, the 2013 Employee Stock Purchase Plan, or the 2013 ESPP. On January 1, 2023, the annual increase for the 2013 ESPP resulted in an additional 509,091 shares authorized for issuance. We issued 104,867 shares and 94,888 shares during the years ended December 31, 2022 and 2021, respectively, under the 2013 ESPP. The 2013 ESPP provides participating employees with the opportunity to purchase up to an aggregate of 1,854,545 shares of our common stock. As of December 31, 2022, we had 1,289,780 shares available for future issuance under the 2013 ESPP. Stock-based compensation expense During the years ended December 31, 2022, 2021 and 2020, we recorded stock-based compensation expense for employee and non-employee stock options, RSUs, PSUs, ESPP shares and other stock-based awards. Stock-based compensation expense by award type included within the consolidated statements of operations is as follows: (In thousands) 2022 2021 2020 Stock options $ 23,731 $ 30,985 $ 37,705 Restricted stock units 21,670 21,510 19,893 Performance-based stock units 2,919 — 1,760 Employee Stock Purchase Plan 976 1,013 1,463 Other stock awards — — 781 Total stock-based compensation expense $ 49,296 $ 53,508 $ 61,602 Expenses related to equity-based awards were allocated as follows in the consolidated statements of operations: (In thousands) 2022 2021 2020 Research and development expense $ 20,988 $ 24,527 $ 27,119 Selling, general and administrative expense 28,308 28,981 34,483 Total stock-based compensation expense $ 49,296 $ 53,508 $ 61,602 No related tax benefits were recognized for the years ended December 31, 2022, 2021 and 2020. The fair value of each stock option granted to employees and non-employees is estimated on the date of grant using the Black-Scholes option-pricing model. The following table summarizes the weighted average assumptions used in calculating the grant date fair value of the awards: 2022 2021 2020 Risk-free interest rate 2.55 % 0.72 % 1.24 % Expected dividend yield — — — Expected term (in years) 6.03 6.05 6.05 Expected volatility 55.30 % 61.72 % 73.80 % Expected term We use the “simplified method” as prescribed by the Securities and Exchange Commission Staff Accounting Bulletin No. 107, Share Based Payments , to estimate the expected term of stock option grants. Under this approach, the weighted-average expected life is presumed to be the average of the contractual term of ten years and the weighted-average vesting term of the stock options, taking into consideration multiple vesting tranches. We utilize this method due to lack of historical data and the plain-vanilla nature of our share-based awards. Volatility The expected volatility has been determined using Agios' historical volatilities for a period equal to the expected term of the option grant. Risk-free rate The risk-free rate is based on the yield curve of U.S. Treasury securities with periods commensurate with the expected term of the options being valued. Dividends We have never paid, and do not anticipate paying, any cash dividends in the foreseeable future, and, therefore, use an expected dividend yield of zero in the option-pricing model. Forfeitures We account for forfeitures as they occur and, therefore, do not estimate forfeitures. |
Net Income (Loss) per Share
Net Income (Loss) per Share | 12 Months Ended |
Dec. 31, 2022 | |
Earnings Per Share [Abstract] | |
Net Income (Loss) per Share | Net Income (Loss) per Share Basic net income (loss) per share is calculated by dividing net income (loss) by the weighted-average shares outstanding during the period, without consideration for common stock equivalents. Diluted net income (loss) per share is calculated by adjusting weighted-average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, determined using the treasury stock method. For purposes of the dilutive net income (loss) per share calculation, stock options, RSUs, PSUs and MSUs for which the performance and market vesting conditions, respectively, have been deemed probable, and 2013 ESPP shares are considered to be common stock equivalents, while PSUs and MSUs with performance and market vesting conditions, respectively, that were not deemed probable as of December 31, 2022 are not considered to be common stock equivalents. We utilize the control number concept in the computation of diluted earnings per share to determine whether potential common stock equivalents are dilutive. The control number used is loss from continuing operations. The control number concept requires that the same number of potentially dilutive securities applied in computing diluted earnings per share from continuing operations be applied to all other categories of income or loss, regardless of their anti-dilutive effect on such categories. Since we had a net loss from continuing operations for all periods presented, no dilutive effect has been recognized in the calculation of income (loss) from discontinued operations per share or net income (loss) per share. Basic and diluted net loss per share were the same for all periods presented. The following common stock equivalents were excluded from the calculation of diluted net loss per share applicable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: Years ended December 31, 2022 2021 2020 Stock options 5,772,564 4,798,826 6,143,046 Restricted stock units 1,117,921 1,002,924 1,284,378 Employee Stock Purchase Plan shares 42,026 39,864 46,439 Total 6,932,511 5,841,614 7,473,863 |
Income Taxes
Income Taxes | 12 Months Ended |
Dec. 31, 2022 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | Income Taxes The domestic and foreign components of loss from continuing operations before income taxes are as follows: (In thousands) 2022 2021 2020 Domestic $ (231,767) $ (356,665) $ (330,669) Foreign (34) 155 1,364 Total $ (231,801) $ (356,510) $ (329,305) We did not have any material provision for income taxes for the years ended December 31, 2022, 2021 and 2020. A reconciliation of the expected income tax benefit (expense) computed using the federal statutory income tax rate to our effective income tax rate is as follows for the years ended December 31, 2022, 2021 and 2020: 2022 2021 2020 Income tax benefit computed at federal statutory tax rate 21.0 % 21.0 % 21.0 % State taxes, net of federal benefit 2.9 % 2.6 % 2.5 % Change in valuation allowance (25.7) % (24.5) % (28.2) % General business credits and other credits 5.2 % 5.3 % 7.0 % Permanent differences and other adjustments (2.3) % (3.9) % (1.6) % Stock based compensation (1.1) % (0.5) % (0.7) % Total — % — % — % Deferred income taxes reflect the net tax effects of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of our deferred tax assets and liabilities for the years ended December 31, 2022 and 2021 are as follows: (In thousands) 2022 2021 Deferred tax assets: Net operating loss carryforwards $ 32,907 $ 39,186 Tax credit carryforwards 163,780 152,128 Purchased intangible assets 11,583 12,150 Stock-based compensation 26,236 27,217 Operating lease liability 21,042 22,963 Non-deductible accruals and reserves, including inventory 3,992 4,033 Section 174 R&D expense 56,565 — Total deferred tax assets 316,105 257,677 Depreciation and amortization (3,767) (3,168) Operating lease right of use asset (16,345) (18,031) Less: valuation allowance (295,993) (236,478) Net deferred taxes $ — $ — The Tax Cuts and Jobs Act (TCJA) requires taxpayers to capitalize and amortize research and experimental expenditures under section 174 for tax years beginning after December 31, 2021. This rule became effective for the Company during the year ending December 31, 2022 and resulted in the capitalization of research and development costs of $261.4 million. We will amortize these costs for tax purposes over 5 years if the research and development was performed in the U.S. and over 15 years if the research and development was performed outside the U.S. As of December 31, 2022, we had net operating loss carryforwards, or NOLs, available to reduce state and foreign income taxes of approximately $1.2 billion and $65.2 million, respectively. At December 31, 2022, we also had available research and development tax credits for federal and state income tax purposes of approximately $16.9 million and $25.7 million, respectively. If not utilized, the credits begin to expire in 2039 and 2027 for federal and state income tax purposes, respectively. We engaged in clinical testing activities and incurred expenses that qualify for the federal orphan drug tax credit. At December 31, 2022, we had available orphan drug tax credits for federal purposes only of approximately $126.5 million. If not utilized, the orphan drug credits begin to expire in 2035. As provided by Section 382 of the Internal Revenue Code of 1986, or Section 382, and similar state provisions, utilization of NOLs and tax credit carryforwards may be subject to substantial annual limitations due to ownership change limitations that have previously occurred or that could occur in the future. Ownership changes may limit the amount of NOLs and tax credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. In general, an ownership change, as defined by Section 382, results from transactions that increase the ownership of five percent stockholders in the stock of a corporation by more than 50 percent in the aggregate over a three year period. We completed a review of our changes in ownership through December 31, 2022 and determined that transactions have resulted in no ownership changes during the year ended December 31, 2022, as defined by Section 382. The impact of the historical ownership changes has been reflected in our deferred tax assets in the table above. As required by ASC 740, we have evaluated the positive and negative evidence bearing upon the realizability of our deferred tax assets. Based on the weight of available evidence, both positive and negative, we recorded a valuation allowance of $296.0 million and $236.5 million as of December 31, 2022 and December 31, 2021, respectively, because we have determined that it is more likely than not that these assets will not be fully realized. The valuation allowance increased by $59.5 million for the year ended December 31, 2022 primarily due to the Section 174 R&D expense capitalization and decreased by $358.3 million for the year ended December 31, 2021 primarily due to the utilization of net operating losses and tax credits. The following table presents our change in valuation allowance for the years ended December 31, 2022 and, 2021: (in thousands) 2022 2021 Valuation allowance at the beginning of the year $ 236,478 $ 594,752 Increase (decrease) for the current period 59,515 (358,274) Valuation allowance at the end of the year $ 295,993 $ 236,478 As of December 31, 2022, the unremitted earnings of our foreign subsidiaries are not material. We have not provided for U.S. income taxes or foreign withholding taxes on these earnings as it is our current intention to permanently reinvest these earnings outside the U.S. The tax liability on these earnings is also not material. Events that could trigger a tax liability include, but are not limited to, distributions, reorganizations or restructurings and/or tax law changes. We apply the accounting guidance in ASC 740 related to accounting for uncertainty in income taxes. Our reserves related to taxes are based on a determination of whether, and how much of, a tax benefit taken by us in our tax filings or positions is more likely than not to be realized following resolution of any potential contingencies present related to the tax benefit. The following table presents our unrecognized tax benefits activity for the years ended December 31, 2022 and 2021: (In thousands) 2022 2021 Unrecognized tax benefits at the beginning of the year $ 24,220 $ 21,131 Gross increases - current period tax positions 1,970 3,089 Unrecognized tax benefits at the end of the year $ 26,190 $ 24,220 We will recognize interest and penalties related to uncertain tax positions above the line as an expense to continuing operations. As of December 31, 2022 and 2021, we had no accrued interest or penalties related to uncertain tax positions and no such amounts have been recognized. If all of the Company’s unrecognized tax benefits as of December 31, 2022 were to become recognizable in the future, we would record $26.2 million of unrecognized tax benefits. The uncertain tax position does not impact our effective income tax rate due to the full valuation allowance. We are subject to taxation in the United States, Switzerland, Netherlands, Germany, Italy and France. The statute of limitations for assessment by the IRS and state tax authorities is open for tax years ending December 31, 2022, 2021, 2020, and 2019, although carryforward attributes that were generated for tax years prior to 2019 may still be adjusted upon examination by the IRS or state tax authorities if they either have been, or will be, used in a future period. The statute of limitations for assessment in Switzerland remains open for tax years ending December 31, 2022, 2021, 2020, and 2019. The Company’s subsidiaries in the Netherlands and Germany were incorporated in 2019 and therefore the statute of limitations for assessment that remain open in these jurisdictions are for the tax years ending December 31, 2022, 2021, 2020 and 2019. The Company’s subsidiaries in Italy and France were incorporated in 2020 and therefore the statute of limitations for assessment that remain open in these jurisdictions are for the tax years ending December 31, 2022, 2021 and 2020. There are currently no federal, state or foreign audits in progress. |
Property and Equipment, net
Property and Equipment, net | 12 Months Ended |
Dec. 31, 2022 | |
Property, Plant and Equipment [Abstract] | |
Property and Equipment, net | Property and Equipment, net Property and equipment, net consisted of the following at December 31: (In thousands) 2022 2021 Laboratory equipment $ 23,182 $ 22,165 Computer equipment and software 6,179 6,913 Leasehold improvements 37,277 32,726 Furniture and fixtures 3,514 3,035 Office equipment 2,248 1,690 Construction in progress 657 7,368 Total property and equipment 73,057 73,897 Less: accumulated depreciation (50,070) (44,974) Total property and equipment, net $ 22,987 $ 28,923 Depreciation expense for the years ended December 31, 2022, 2021 and 2020 was $8.4 million, $8.8 million and $9.4 million, respectively. |
Common Stock
Common Stock | 12 Months Ended |
Dec. 31, 2022 | |
Equity [Abstract] | |
Common Stock | Common StockWe are authorized to issue 125,000,000 shares of our common stock. Holders of common stock are entitled to one vote per share. Additionally, holders of common stock are entitled to receive dividends, if and when declared by our board of directors, and to share ratably in our assets legally available for distribution to our shareholders in the event of liquidation. |
Share Repurchase Program
Share Repurchase Program | 12 Months Ended |
Dec. 31, 2022 | |
Equity [Abstract] | |
Share Repurchase Program | Share Repurchase Program On March 25, 2021, we announced that our board of directors authorized the Repurchase Program for the repurchase of up to $1.2 billion of our outstanding shares of common stock. On March 31, 2021, in connection with the Repurchase Program, we entered into a definitive share repurchase agreement with BMS to repurchase 7.1 million shares of our common stock held by certain subsidiaries of BMS for an aggregate purchase price of $344.5 million, or $48.38 per share. This repurchase was completed on April 5, 2021. Further, on April 2, 2021, in connection with the Repurchase Program, we entered into a Rule 10b5-1 repurchase plan to which we may repurchase up to $600.0 million of shares of our common stock. As of December 31, 2022, we have repurchased approximately 9.1 million shares of common stock for $458.0 million, or $50.35 per share, under the Rule 10b5-1 repurchase plan. In total, as of December 31, 2022, we have repurchased 16.2 million shares of common stock for $802.5 million, or $49.49 per share, under the Repurchase Program. On October 5, 2021, we terminated our Rule 10b5-1 share repurchase plan and on October 13, 2021, we entered into a Rule 10b-18 repurchase plan that allows us to conduct open market repurchases over time up to our remaining authorization under the Repurchase Program. We have paused our share repurchases for the foreseeable future. Repurchased shares are held as treasury stock until they are retired or re-issued. Treasury stock purchases are accounted for under the cost method whereby the entire cost of the acquired stock is recorded as treasury stock. Repurchases of our common stock are accounted for as of the settlement date. There were no retirements or re-issuances of treasury stock during the year ended December 31, 2022. |
Discontinued Operations
Discontinued Operations | 12 Months Ended |
Dec. 31, 2022 | |
Discontinued Operations and Disposal Groups [Abstract] | |
Discontinued Operations | Discontinued Operations On March 31, 2021, we completed the sale of our oncology business to Servier. We determined the sale of the oncology business represented a strategic shift that had a major effect on our business and therefore met the criteria for classification as discontinued operations at March 31, 2021. Accordingly, the oncology business is reported as discontinued operations in accordance with ASC 205-20, Discontinued Operations . The related assets and liabilities of the oncology business were classified as assets and liabilities of discontinued operations in the consolidated balance sheets and the results of operations from the oncology business as discontinued operations in the consolidated statements of operations. Applicable amounts in prior years have been recast to conform to this discontinued operations presentation. We recognized a gain on the sale of the oncology business upon closing. The following table presents the net liabilities transferred for the sale of the oncology business at March 31, 2021: (in thousands) March 31, 2021 Assets Current assets: Accounts receivable, net $ 25,386 Collaboration receivable – related party 2,253 Collaboration receivable – other 2,438 Inventory 16,190 Prepaid expenses and other current assets 7,125 Total current assets of discontinued operations 53,392 Other non-current assets 2,234 Total assets of discontinued operations $ 55,626 Liabilities Current liabilities: Accounts payable $ 4,245 Accrued expenses 30,288 Total current liabilities of discontinued operations 34,533 Liability related to the sale of future revenue, net of debt issuance costs 264,281 Total liabilities of discontinued operations 298,814 Net liabilities distributed to Servier $ (243,188) The following table presents the gain on the sale for the year ended December 31, 2021: (in thousands) December 31, 2021 Cash proceeds $ 1,802,936 Less: transaction and insurance costs (53,573) Plus: net liabilities distributed, including working capital adjustment 239,770 Gain on sale, pre-tax 1,989,133 Income tax expense (12,799) Gain on sale, net of tax $ 1,976,334 As of December 31, 2022 and December 31, 2021, there were no assets or liabilities classified as discontinued operations. The following table presents the financial results of the discontinued operations: (in thousands) 2021 2020 Revenues: Product revenue, net $ 36,909 $ 121,089 Collaboration revenue – related party 1,350 68,274 Collaboration revenue – other 491 3,571 Royalty revenue – related party 2,659 10,262 Total revenue 41,409 203,196 Cost and expenses: Cost of sales 706 2,805 Research and development 41,564 146,659 Selling, general and administrative 8,551 33,965 Total cost and expenses 50,821 183,429 (Loss) income from discontinued operations (9,412) 19,767 Non-cash interest expense for the sale of future revenue (5,697) (17,832) Gain on the sale of the oncology business 1,989,133 — Income from discontinued operations, pre-tax 1,974,024 1,935 Income tax expense (12,799) — Net income from discontinued operations $ 1,961,225 $ 1,935 In accordance with ASC 205-20, only expenses specifically identifiable and related to a business to be disposed may be presented in discontinued operations. As such, the research and development, marketing, selling and general and administrative expenses in discontinued operations include corporate costs incurred directly to solely support our oncology business. We also entered into a Transition Services Agreement with Servier, through which we provided transitional services related to discovery, clinical development, technical operations, commercial and general and administrative related activities through March 31, 2022. The milestone payment for approval of vorasidenib and royalty payments related to vorasidenib and TIBSOVO® represent contingent consideration. Contingent consideration has been accounted for as a gain contingency in accordance with ASC 450, Contingencies , and will be recognized in earnings in the period when realizable. As described in Note 1, Nature of Business , on October 27, 2022, we sold our rights to future contingent payments to entities affiliated with Sagard and recognized income of $127.9 million within the gain on sale of contingent payments line item in our consolidated statements of operations for the year ended December 31, 2022. |
Commitments and Contingent Liab
Commitments and Contingent Liabilities | 12 Months Ended |
Dec. 31, 2022 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingent Liabilities | Commitments and Contingent Liabilities Manufacturing Commitments We are party to various agreements with contract manufacturing organizations that we are not contractually able to terminate for convenience and avoid any and all future obligations to the vendors. Under such agreements, we are obligated to make certain minimum payments, with the exact amounts in the event of termination to be based on the timing of the termination and the exact terms of the agreement. Legal Contingencies From time to time, we may be involved in disputes and legal proceedings in the ordinary course of business. These proceedings may include allegations of infringement of intellectual property, employment or other matters. We do not have any ongoing legal proceedings that, based on our estimates, could have a material effect on our consolidated financial statements. |
Defined Contribution Benefit Pl
Defined Contribution Benefit Plan | 12 Months Ended |
Dec. 31, 2022 | |
Retirement Benefits [Abstract] | |
Defined Contribution Benefit Plan | Defined Contribution Benefit PlanWe sponsor a 401(k) retirement plan, in which substantially all of our full-time employees are eligible to participate. Participants may contribute a percentage of their annual compensation to this plan, subject to statutory limitations. We will make matching contributions equal to 100% of the employee’s contributions, subject to a maximum of 4% of eligible compensation. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 12 Months Ended |
Dec. 31, 2022 | |
Accounting Policies [Abstract] | |
Principles of consolidation | Principles of consolidation The consolidated financial statements include our accounts and the accounts of our wholly owned subsidiaries, Agios Securities Corporation, Agios International Sarl (GmbH), Agios Germany GmbH, Agios Netherlands B.V., Agios Italy S.R.L., Agios France SARL, and Agios Limited. All intercompany transactions have been eliminated in consolidation. The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles, or U.S. GAAP. |
Use of estimates | Use of estimates The preparation of our consolidated financial statements requires us to make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, equity, revenues and expenses and related disclosure of contingent assets and liabilities. On an ongoing basis we evaluate our estimates, judgments and methodologies. We base our estimates on historical experience and on various other assumptions that we believe are reasonable, the results of which form the basis for making |
Cash and cash equivalents | Cash and cash equivalents We consider highly liquid investments with a maturity of three months or less when purchased to be cash equivalents. Cash equivalents are stated at fair value. |
Accounts receivable, net | Accounts receivable, net Our trade accounts receivable arise from product sales and represent amounts due from specialty distributors and specialty pharmacy providers in the U.S. We monitor the financial performance and creditworthiness of our customers so that we can properly assess and respond to changes in their credit profile. We reserve against these receivables for estimated losses that may arise from a customer’s inability to pay. Amounts determined to be uncollectible are charged or written-off against the reserve. |
Inventory | Inventory Inventory is stated at the lower of cost or estimated net realizable value on a first-in, first-out basis. Prior to the regulatory approval of our product candidates, we incur expenses for the manufacture of drug product that could potentially be available to support the commercial launch of those products. Until the date at which regulatory approval has been received or is otherwise considered probable, we record all such costs as research and development expenses. Upon approval of our wholly owned product, PYRUKYND®, by the FDA on February 17, 2022 for the treatment of hemolytic anemia in adults with PK deficiency in the United States, we began to capitalize inventories of PYRUKYND®. |
Revenue recognition | Revenue recognition Under Accounting Standards Codification 606, Revenue from Contracts with Customers , or ASC 606, revenue is recognized when the customer obtains control of promised goods or services, in an amount that reflects the consideration that we expect to receive in exchange for those goods or services. To determine revenue recognition for arrangements that have been determined to be within the scope of ASC 606, we perform the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) we satisfy a performance obligation. We only apply the five-step model to contracts when it is probable that we will collect the consideration we are entitled to in exchange for the goods or services we transfer to the customer. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Once the contract is determined to be within the scope of ASC 606, we assess the goods or services promised within each contract and determine those that are performance obligations, and assess whether each promised good or service is distinct. We will then recognize as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Product Revenue We generate product revenue from sales of PYRUKYND® to a limited number of specialty distributors and specialty pharmacy providers, or collectively, the Customers. These Customers subsequently resell PYRUKYND® to pharmacies or dispense directly to patients. In addition to distribution agreements with Customers, we enter into arrangements with healthcare providers and payors that provide for government-mandated and/or privately-negotiated rebates, chargebacks and discounts with respect to the purchase of PYRUKYND®. The performance obligation related to the sale of PYRUKYND® is satisfied and revenue is recognized when the Customer obtains control of the product, which occurs at a point in time, typically upon delivery to the Customer. Revenues from product sales are recorded at the net sales price, or transaction price, which includes estimates of variable consideration for which reserves are established and result from contractual adjustments, government rebates, returns and other allowances that are offered within the contracts with our Customers, healthcare providers, payors and other indirect customers relating to the sale of our products. Contractual Adjustments . We generally provide Customers with discounts, including prompt pay discounts, and allowances that are explicitly stated in the contracts and are recorded as a reduction of revenue in the period the related product revenue is recognized. In addition, we receive sales order management, data and distribution services from certain Customers. Chargebacks and discounts represent the estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices charged to Customers who directly purchase the product from us. Customers charge us for the difference between what they pay for the product and the ultimate selling price to the qualified healthcare providers. These reserves are estimated using the expected value method, based upon a range of possible outcomes that are probability-weighted for the estimated channel mix and are established in the same period that the related revenue is recognized, resulting in a reduction of product revenue. Government Rebates . Government rebates include Medicare, TriCare, and Medicaid rebates, which we estimate using the expected value method, based upon a range of possible outcomes that are probability-weighted for the estimated payor mix. These reserves are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue. For Medicare, we also estimate the number of patients in the prescription drug coverage gap for whom we will owe an additional liability under the Medicare Part D program. Returns . We estimate the amount of product sales that may be returned by Customers and record this estimate as a reduction of revenue in the period the related product revenue is recognized. We currently estimate product return liabilities using the expected value method, based on available industry data, including our visibility into the inventory remaining in the distribution channel. |
Cost of sales | Cost of sales Cost of sales consists primarily of manufacturing costs for sales of PYRUKYND®. Based on our policy to expense costs associated with the manufacturing of our products prior to regulatory approval, certain of the manufacturing costs associated with product shipments of PYRUKYND® recorded during the twelve months ended December 31, 2022 were expensed prior to February 17, 2022 and, therefore, are not included in costs of sales during the twelve months ended December 31, 2022. |
Marketable securities | Marketable securities Marketable securities at December 31, 2022 and 2021 consisted of investments in U.S. Treasuries, government securities and corporate debt securities. We determine the appropriate classification of the securities at the time they are acquired and evaluate the appropriateness of such classifications at each balance sheet date. We classify our marketable securities as available-for-sale pursuant to ASC 320, Investments – Debt and Equity Securities . Marketable securities are recorded at fair value. Unrealized gains and losses are included as a component of accumulated other comprehensive (loss) income in the consolidated balance sheets and statements of stockholders’ equity and a component of total comprehensive (loss) income in the consolidated statements of comprehensive (loss) income, until realized. Realized gains and losses are included in investment income on a specific-identification basis. At December 31, 2022 and 2021, we held both current and non-current investments. Investments classified as current have maturities of less than one year. Investments classified as non-current are those that: (i) have a maturity of one We review marketable securities for impairment whenever the fair value of a marketable security is less than the amortized cost and evidence indicates that a marketable security’s carrying amount is not recoverable. Unrealized losses are evaluated for impairment under ASC 326, Financial Instruments - Credit Losses , to determine if the impairment is credit-related or noncredit-related. Credit-related impairment is recognized as an allowance on the balance sheet with a corresponding adjustment to earnings, and noncredit-related impairment is recognized in other comprehensive (loss) income, net of taxes. Evidence considered in this assessment includes reasons for the impairment, compliance with our investment policy, the severity of the impairment, collectability of the security, and any adverse conditions specifically related to the security, an industry, or geographic area. |
Fair value measurements | Fair value measurements We record cash equivalents and marketable securities at fair value. ASC 820, Fair Value Measurements and Disclosures , establishes a fair value hierarchy for those instruments measured at fair value that distinguishes between assumptions based on market data (observable inputs) and our own assumptions (unobservable inputs). The hierarchy consists of three levels: Level 1 – Unadjusted quoted prices in active markets for identical assets or liabilities. Level 2 – Quoted prices for similar assets and liabilities in active markets, quoted prices in markets that are not active, or inputs which are observable, either directly or indirectly, for substantially the full term of the asset or liability. Level 3 – Unobservable inputs that reflect our own assumptions about the assumptions market participants would use in pricing the asset or liability in which there is little, if any, market activity for the asset or liability at the measurement date. Our financial assets, which include cash equivalents and marketable securities, have been initially valued at the transaction price, and subsequently revalued at the end of each reporting period, utilizing third-party pricing services or other observable market data. The pricing services utilize industry standard valuation models, including both income and market based approaches, and observable market inputs to determine value. After completing our validation procedures, we did not adjust or override any fair value measurements provided by the pricing services as of December 31, 2022 or 2021. Fair value information for these assets, including their classification in the fair value hierarchy is included in Note 3 , Fair Value Measurements . There have been no changes to the valuation methods during the years ended December 31, 2022 and 2021. We evaluate transfers between levels at the end of each reporting period. The carrying amounts of other receivables, prepaid expenses and other current assets, accounts payable, and accrued expenses approximate their fair values due to their short-term maturities. |
Concentrations of credit risk | Concentrations of credit risk Financial instruments which potentially subject us to credit risk consist primarily of cash, cash equivalents, and marketable securities. We hold these investments in highly rated financial institutions, and, by policy, limit the amounts of credit exposure to any one financial institution. These amounts at times may exceed federally insured limits. We have not experienced any credit losses in such accounts and do not believe we are exposed to any significant credit risk on these funds. We have no off-balance sheet concentrations of credit risk, such as foreign currency exchange contracts, option contracts, or other hedging arrangements. |
Property and equipment | Property and equipment Property and equipment consist of laboratory equipment, computer equipment and software, leasehold improvements, furniture and fixtures, and office equipment. Costs of major additions and betterment are capitalized; maintenance and repairs, which do not improve or extend the life of the respective assets, are charged to expense as incurred. Upon retirement or sale, the cost of the disposed asset and the related accumulated depreciation are removed from the accounts and the resulting gain or loss is recognized. Property and equipment is stated at cost, and depreciated using the straight-line method over the estimated useful lives of the respective assets: Years Laboratory equipment 5 Computer equipment and software 3 Furniture and fixtures 5 Office equipment 5 Leasehold improvements are amortized over the lesser of the remaining lease term or the estimated useful life of the improvement. |
Impairment of long-lived assets | Impairment of long-lived assets We periodically evaluate our long-lived assets for potential impairment in accordance with ASC 360, Property, Plant and Equipment . Potential impairment is assessed when there is evidence that events or changes in circumstances indicate that the carrying amount of an asset may not be recovered. Recoverability of these assets is assessed based on the undiscounted expected future cash flows from the assets, considering a number of factors, including past operating results, budgets and |
Leases | Leases We determine if an arrangement is a lease at inception. An arrangement is determined to contain a lease if the contract conveys the right to control the use of an identified property or equipment for a period of time in exchange for consideration. If we can benefit from the various underlying assets of a lease on their own or together with other resources that are readily available, or if the various underlying assets are neither highly dependent on nor highly interrelated with other underlying assets in the arrangement, they are considered to be a separate lease component. In the event multiple underlying assets are identified, the lease consideration is allocated to the various components based on each of the component’s relative fair value. Operating lease assets represent our right to use an underlying asset for the lease term and operating lease liabilities represent our obligation to make lease payments arising from the leasing arrangement. Operating lease assets and operating lease liabilities are recognized at commencement date based on the present value of lease payments over the lease term. As most of our leases do not provide an implicit rate, in determining the operating lease liabilities we use an estimate of our incremental borrowing rate. The incremental borrowing rate is determined using two alternative credit scoring models to estimate our credit rating, adjusted for collateralization. The calculation of the operating lease assets includes any lease payments made and excludes any lease incentives. Our lease terms may include options to extend or terminate the lease when it is reasonably certain that we will exercise that option. For operating leases, we record operating lease assets and lease liabilities in our consolidated balance sheets. Lease expense for lease payments is recognized on a straight-line basis over the lease term. Short-term leases, or leases that have a lease term of 12 months or less at commencement date, are excluded from this treatment and are recognized on a straight-line basis over the term of the lease. We have not entered into any material short-term leases or financing leases as of December 31, 2022. |
Research and development costs | Research and development costs Research and development costs, including those accrued as of each balance sheet date, are expensed as incurred. These costs include salaries and personnel-related costs, consulting fees, fees paid for contract research services, fees paid to contract research organizations, or CROs, and other third parties in connection with clinical trials and preclinical development activities, fees paid to investigative sites in connection with clinical studies, the costs associated with the product manufacturing, development, and distribution of clinical supplies, the costs of laboratory equipment and facilities, and other external costs. Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are deferred and capitalized. Additionally, there may be instances in which payments made to our vendors will exceed the level of services provided, and result in a prepayment of the research and development expense. The capitalized amounts are expensed as the related goods are delivered or the services are performed. We estimate the time period over which services will be performed and the level of effort to be expended in each period. If the actual timing of the performance of services or the level of effort varies from our estimate, we adjust the accrual or prepaid accordingly. |
Stock-based compensation | Stock-based compensation We account for stock-based compensation awards in accordance with ASC 718, Compensation –Stock Compensation , or ASC 718. For stock-based awards granted to employees, non-employees and members of the board of directors for their services and for participation in our employee stock purchase plan, we estimate the grant date fair value of each option award using the Black-Scholes option-pricing model. The use of the Black-Scholes option-pricing model requires us to make assumptions with respect to the expected term of the option, the expected volatility of the common stock consistent with the expected life of the option, risk-free interest rates and expected dividend yields of the common stock. For awards subject to service-based vesting conditions, we recognize stock-based compensation expense equal to the grant date fair value of stock options on a straight-line basis over the requisite service period. For awards subject to both performance and service-based vesting conditions, we recognize stock-based compensation expense over the remaining service period if the performance condition is considered probable of achievement using management’s best estimates. |
Income taxes | Income taxes Income taxes are recorded in accordance with ASC 740, Accounting for Income Taxes , or ASC 740, which provides for deferred taxes using an asset and liability approach. We recognize deferred tax assets and liabilities for the expected future tax consequences of events that have been included in our financial statements or tax returns. We determine our deferred tax assets and liabilities based on differences between the financial reporting and tax bases of assets and liabilities, which are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. Valuation allowances are provided, if based upon the weight of available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. We also account for uncertain tax positions in accordance with the provisions of ASC 740. When uncertain tax positions exist, we recognize the tax benefit of tax positions to the extent that the benefit will more likely than not be realized. The determination as to whether the tax benefit will more likely than not be realized is based upon the technical merits of the tax position as well as consideration of the available facts and circumstances. |
Comprehensive income (loss) | Comprehensive income (loss) Comprehensive income (loss) is defined as the change in equity of a business enterprise during a period from transactions, and other events and circumstances, and currently consists of net loss and unrealized gains and losses on available-for-sale securities. Accumulated other comprehensive (loss) income consists entirely of unrealized gains and losses from available-for-sale securities as of December 31, 2022 and 2021. |
Net income (loss) per share | Net income (loss) per share Basic net income (loss) per share is calculated by dividing net income (loss) by the weighted-average shares outstanding during the period, without consideration for common stock equivalents. Diluted net income (loss) per share is calculated by adjusting weighted-average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, determined using the treasury-stock method. For purposes of the dilutive net income (loss) per share calculation, stock options, restricted stock units, or RSUs, performance-based stock units, or PSUs, and market-based stock units, or MSUs, for which the performance and market vesting conditions, respectively, have been deemed probable, and employee stock purchase plan shares are considered to be common stock equivalents but are excluded from the calculation of diluted net income (loss) per share as their effect would be anti-dilutive. We utilize the control number concept in the computation of diluted earnings per share to determine whether potential common stock equivalents are dilutive. The control number used is loss from continuing operations. The control number concept requires that the same number of potentially dilutive securities applied in computing diluted earnings per share from continuing operations be applied to all other categories of income or loss, regardless of their anti-dilutive effect on such categories. Since we had a net loss from continuing operations for all periods presented, no dilutive effect has been recognized in the calculation of income (loss) from discontinued operations per share or net income (loss) per share. |
Segment and geographic information | Segment and geographic information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker or decision-making group in making decisions on how to allocate resources and assess performance. Our chief operating decision maker is the chief executive officer. Our chief operating decision maker and we view our operations and manage our business as one operating segment. |
Discontinued operations | Discontinued operations We accounted for the sale of our oncology business in accordance with ASC 205, Discontinued Operations and Accounting Standards Update, or ASU, No. 2014-08, Reporting of Discontinued Operations and Disclosures of Disposals of Components of an Entity . We followed the held-for-sale criteria as defined in ASC 360, Property, Plant and Equipment, and ASC 205. ASC 205 requires that a component of an entity that has been disposed of or is classified as held for sale and has operations and cash flows that can be clearly distinguished from the rest of the entity be reported as assets held for sale and discontinued operations. In the period a component of an entity has been disposed of or classified as held for sale, the results of operations for the periods presented are reclassified into separate line items in the consolidated statements of operations. Assets and liabilities are also reclassified into separate line items on the related consolidated balance sheets for the periods presented. The statements of cash flows for the periods presented are also reclassified to reflect the results of discontinued operations as separate line items. ASU 2014-08 requires that only a disposal of a component of an entity, or a group of components of an entity, that represents a strategic shift that has, or will have, a major effect on the reporting entity’s operations and financial results be reported in the financial statements as discontinued operations. ASU 2014-08 also provides guidance on the financial statement presentations and disclosures of discontinued operations. Due to the sale of the oncology business during the first quarter of 2021, in accordance with ASC 205, we have classified the results of the oncology business as discontinued operations in our consolidated statements of operations and cash flows for all periods presented, and refer to Note 15 , Discontinued Operations . All assets and liabilities associated with our oncology business were therefore classified as assets and liabilities of discontinued operations in our consolidated balance sheets for the periods presented. All amounts included in the notes to the consolidated financial statements relate to continuing operations unless otherwise noted. |
Treasury stock | Treasury stockTreasury stock purchases are accounted for under the cost method whereby the entire cost of the acquired stock is recorded as treasury stock. |
Recent accounting pronouncements | Recent accounting pronouncements In June 2016, the Financial Accounting Standards Board, or FASB, issued ASU 2016-13, Financial Instruments - Credit Losses (Topic 326) , which introduces new guidance for the accounting for credit losses on instruments within its scope. The new guidance introduces an approach based on expected losses to estimate credit losses on certain types of financial instruments. Credit losses relating to available-for-sale debt securities will also be recorded through an allowance for credit losses rather than as a reduction in the amortized cost basis of the securities. The guidance is effective for fiscal years beginning after December 31, 2019, including interim periods within those years. The Company adopted this amendment as of January 1, 2020, which eliminated the concept of other-than-temporary impairments and required credit losses on debt securities to be recorded through an allowance for credit losses instead of as a reduction in the amortized cost basis of the securities. Application of the amendments is through a cumulative-effect adjustment to retained earnings as of the effective date. There was no material impact to the Company’s consolidated financial position, results of operation, or cash flows. Other accounting standards that have been issued by the FASB or other standards-setting bodies that do not require adoption until a future date are not expected to have a material impact on our financial statements upon adoption. |
Subsequent events | Subsequent events We considered events or transactions occurring after the balance sheet date, but prior to the issuance of the consolidated financial statements, for potential recognition or disclosure in our consolidated financial statements. All significant subsequent events have been properly disclosed in the consolidated financial statements. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Accounting Policies [Abstract] | |
Estimated Useful Lives of Property and Equipment | Property and equipment is stated at cost, and depreciated using the straight-line method over the estimated useful lives of the respective assets: Years Laboratory equipment 5 Computer equipment and software 3 Furniture and fixtures 5 Office equipment 5 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Fair Value Disclosures [Abstract] | |
Cash Equivalents and Marketable Securities Measured at Fair Value on a Recurring Basis | The following table summarizes our cash equivalents and marketable securities measured at fair value and by level (as described in Note 2. Summary of Significant Accounting Policies ) on a recurring basis as of December 31, 2022: (In thousands) Level 1 Level 2 Level 3 Total Cash equivalents $ 37,093 $ 50,909 $ — $ 88,002 Total cash equivalents 37,093 50,909 — 88,002 Marketable securities: U.S. Treasuries — 84,596 — 84,596 Government securities — 331,443 — 331,443 Corporate debt securities — 541,695 — 541,695 Total marketable securities — 957,734 — 957,734 Total cash equivalents and marketable securities $ 37,093 $ 1,008,643 $ — $ 1,045,736 |
Marketable Securities (Tables)
Marketable Securities (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Investments, Debt and Equity Securities [Abstract] | |
Summary of Marketable Securities | Marketable securities at December 31, 2022 consisted of the following: (In thousands) Amortized Unrealized Unrealized Fair Current: U.S. Treasuries $ 68,175 $ 3 $ (811) $ 67,367 Government securities 220,901 8 (5,289) 215,620 Corporate debt securities 363,263 1 (2,391) 360,873 Total Current 652,339 12 (8,491) 643,860 Non-current: U.S. Treasuries 17,418 4 (193) 17,229 Government securities 117,475 7 (1,659) 115,823 Corporate debt securities 183,037 76 (2,291) 180,822 Total Non-current 317,930 87 (4,143) 313,874 Total marketable securities $ 970,269 $ 99 $ (12,634) $ 957,734 Marketable securities at December 31, 2021 consisted of the following: (In thousands) Amortized Cost Unrealized Gains Unrealized Losses Fair Value Current: U.S. Treasuries $ 269,109 $ — $ (36) $ 269,073 Government securities 17,764 1 (10) 17,755 Corporate debt securities 530,490 3 (429) 530,064 Total Current 817,363 4 (475) 816,892 Non-current: U.S. Treasuries 40,607 — (23) 40,584 Government securities 148,820 — (470) 148,350 Corporate debt securities 77,675 — (234) 77,441 Total Non-current 267,102 — (727) 266,375 Total marketable securities $ 1,084,465 $ 4 $ (1,202) $ 1,083,267 |
Inventory (Tables)
Inventory (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Inventory Disclosure [Abstract] | |
Schedule of Inventory | Inventory, which consists of commercial supply of PYRUKYND®, consisted of the following: (In thousands) December 31, December 31, Raw materials $ — $ — Work-in-process 7,550 — Finished goods 942 — Total inventory $ 8,492 $ — |
Leases (Tables)
Leases (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Leases [Abstract] | |
Schedule of Lease Cost and Other Information | The components of lease expense and other information related to leases were as follows: (In millions) 2022 2021 2020 Operating lease costs $ 15,227 $ 15,229 $ 15,241 Cash paid for amounts included in the measurement of operating lease liabilities 17,035 14,411 14,424 |
Schedule of Undiscounted Minimum Rental Commitments | As of December 31, 2022, undiscounted minimum rental commitments under non-cancelable leases, for each of the next five years and total thereafter, were as follows: (In thousands) 2023 $ 16,651 2024 18,660 2025 19,507 2026 20,151 2027 20,755 Thereafter 3,479 Undiscounted minimum rental commitments 99,203 Interest (13,544) Total operating lease liabilities $ 85,659 |
Schedule of Future Minimum Lease Payments to be Received | As of December 31, 2022, the future minimum lease payments to be received under the long-term sublease agreements were as follows: (In thousands) 2023 4,329 2024 4,459 2025 1,101 Total $ 9,889 |
Accrued Expenses (Tables)
Accrued Expenses (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Payables and Accruals [Abstract] | |
Summary of Accrued Expenses | Accrued expenses consisted of the following at December 31: (In thousands) 2022 2021 Accrued compensation $ 18,105 $ 19,818 Accrued research and development costs 8,425 5,980 Accrued professional fees 2,435 2,335 Accrued other 1,385 3,834 Total accrued expenses $ 30,350 $ 31,967 |
Product Revenue (Tables)
Product Revenue (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Revenue from Contract with Customer [Abstract] | |
Schedule of Product Revenue | Product revenue, net, was as follows for the years ended December 31: (In thousands) 2022 2021 2020 Product revenue, net $ 11,740 $ — $ — |
Schedule of Product Revenue Allowance and Reserves | The following table summarizes balances and activity in each of the product revenue allowance and reserve categories for the year ended December 31, 2022: (In thousands) Contractual Adjustments Government Rebates Returns Total Balance at December 31, 2021 $ — $ — $ — $ — Current provisions relating to sales in the current year 497 912 133 1,542 Adjustments relating to prior years — — — — Payments/returns relating to sales in the current year (432) (339) (771) Payments/returns relating to sales in the prior years — — — — Balance at December 31, 2022 $ 65 $ 573 $ 133 $ 771 |
Schedule of Revenue Related Reserves | Total revenue-related reserves above, included in our consolidated balance sheets, are summarized as follows: (In thousands) December 31, 2022 December 31, 2021 Reduction of accounts receivable $ 60 $ — Component of accrued expenses 711 — Total revenue-related reserves $ 771 $ — |
Schedule of Changes in Contract Assets | The following table presents changes in our contract assets during the year ended December 31, 2022: (In thousands) December 31, 2021 Additions Deductions December 31, 2022 Contract assets (1) Accounts receivable, net $ — $ 13,283 $ (11,077) $ 2,206 |
Share-Based Payments (Tables)
Share-Based Payments (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Share-Based Payment Arrangement [Abstract] | |
Summary of Company's Stock Option Activity of all Stock Incentive Plans | The following table summarizes the stock option activity of all stock incentive plans for the year ended December 31, 2022: Number of Stock Options Weighted- Average Exercise Price Weighted- Average Remaining Contractual Term (in years) Aggregate Intrinsic Value (in thousands) Outstanding at December 31, 2021 4,798,826 $ 58.51 6.24 $ 4,697 Granted 1,850,093 28.89 Exercised (15,539) 11.50 Forfeited/Expired (860,816) 60.91 Outstanding at December 31, 2022 5,772,564 $ 48.81 6.50 $ 5,362 Exercisable at December 31, 2022 3,497,660 $ 58.24 4.84 $ 3,141 Vested and expected to vest at December 31, 2022 5,772,564 $ 48.81 6.50 $ 5,362 |
Schedule of Restricted Stock Unit Activity | The following table presents RSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 1,002,924 $ 51.51 Granted 869,766 31.16 Vested (531,304) 50.16 Forfeited (223,465) 41.84 Unvested shares at December 31, 2022 1,117,921 $ 38.30 |
Schedule of Performance-Based Unit Activity | The following table presents PSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 234,059 $ 54.28 Granted 337,243 30.33 Vested (53,777) 54.28 Forfeited (47,190) 49.06 Expired (40,092) 56.52 Unvested shares at December 31, 2022 430,243 $ 35.87 |
Schedule of Market-Based Unit Activity | The following table presents MSU activity for the year ended December 31, 2022: Number of Weighted-Average Unvested shares at December 31, 2021 42,695 $ 41.50 Granted — — Unvested shares at December 31, 2022 42,695 $ 41.50 |
Schedule of Stock-Based Compensation Expense by Award Type Included Within the Condensed Consolidated Statements of Operations | Stock-based compensation expense by award type included within the consolidated statements of operations is as follows: (In thousands) 2022 2021 2020 Stock options $ 23,731 $ 30,985 $ 37,705 Restricted stock units 21,670 21,510 19,893 Performance-based stock units 2,919 — 1,760 Employee Stock Purchase Plan 976 1,013 1,463 Other stock awards — — 781 Total stock-based compensation expense $ 49,296 $ 53,508 $ 61,602 |
Stock-Based Compensation Expense for Employee and Non-Employee Stock Options, Restricted Stock Units, Performance-Based Stock Options, Performance-Based Stock Units and Employee Stock Purchase Plan Shares | Expenses related to equity-based awards were allocated as follows in the consolidated statements of operations: (In thousands) 2022 2021 2020 Research and development expense $ 20,988 $ 24,527 $ 27,119 Selling, general and administrative expense 28,308 28,981 34,483 Total stock-based compensation expense $ 49,296 $ 53,508 $ 61,602 |
Schedule of Grant Date Fair Value Option Award Weighted Average Assumptions Used | The following table summarizes the weighted average assumptions used in calculating the grant date fair value of the awards: 2022 2021 2020 Risk-free interest rate 2.55 % 0.72 % 1.24 % Expected dividend yield — — — Expected term (in years) 6.03 6.05 6.05 Expected volatility 55.30 % 61.72 % 73.80 % |
Net Income (Loss) per Share (Ta
Net Income (Loss) per Share (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Earnings Per Share [Abstract] | |
Common Stock Excluded from Calculation of Diluted Earnings Per Share | The following common stock equivalents were excluded from the calculation of diluted net loss per share applicable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: Years ended December 31, 2022 2021 2020 Stock options 5,772,564 4,798,826 6,143,046 Restricted stock units 1,117,921 1,002,924 1,284,378 Employee Stock Purchase Plan shares 42,026 39,864 46,439 Total 6,932,511 5,841,614 7,473,863 |
Income Taxes (Tables)
Income Taxes (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Income Tax Disclosure [Abstract] | |
Schedule of Domestic and Foreign Components of Loss Before Income Taxes | The domestic and foreign components of loss from continuing operations before income taxes are as follows: (In thousands) 2022 2021 2020 Domestic $ (231,767) $ (356,665) $ (330,669) Foreign (34) 155 1,364 Total $ (231,801) $ (356,510) $ (329,305) |
Reconciliation of Expected Income Tax Benefit (Expense) Computed Using Federal Statutory Income Tax Rate | A reconciliation of the expected income tax benefit (expense) computed using the federal statutory income tax rate to our effective income tax rate is as follows for the years ended December 31, 2022, 2021 and 2020: 2022 2021 2020 Income tax benefit computed at federal statutory tax rate 21.0 % 21.0 % 21.0 % State taxes, net of federal benefit 2.9 % 2.6 % 2.5 % Change in valuation allowance (25.7) % (24.5) % (28.2) % General business credits and other credits 5.2 % 5.3 % 7.0 % Permanent differences and other adjustments (2.3) % (3.9) % (1.6) % Stock based compensation (1.1) % (0.5) % (0.7) % Total — % — % — % |
Company's Deferred Tax Assets and Liabilities | Significant components of our deferred tax assets and liabilities for the years ended December 31, 2022 and 2021 are as follows: (In thousands) 2022 2021 Deferred tax assets: Net operating loss carryforwards $ 32,907 $ 39,186 Tax credit carryforwards 163,780 152,128 Purchased intangible assets 11,583 12,150 Stock-based compensation 26,236 27,217 Operating lease liability 21,042 22,963 Non-deductible accruals and reserves, including inventory 3,992 4,033 Section 174 R&D expense 56,565 — Total deferred tax assets 316,105 257,677 Depreciation and amortization (3,767) (3,168) Operating lease right of use asset (16,345) (18,031) Less: valuation allowance (295,993) (236,478) Net deferred taxes $ — $ — |
Changes in Valuation Allowance | The following table presents our change in valuation allowance for the years ended December 31, 2022 and, 2021: (in thousands) 2022 2021 Valuation allowance at the beginning of the year $ 236,478 $ 594,752 Increase (decrease) for the current period 59,515 (358,274) Valuation allowance at the end of the year $ 295,993 $ 236,478 |
Schedule of Unrecognized Tax Benefits Rollforward | The following table presents our unrecognized tax benefits activity for the years ended December 31, 2022 and 2021: (In thousands) 2022 2021 Unrecognized tax benefits at the beginning of the year $ 24,220 $ 21,131 Gross increases - current period tax positions 1,970 3,089 Unrecognized tax benefits at the end of the year $ 26,190 $ 24,220 |
Property and Equipment, net (Ta
Property and Equipment, net (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Property, Plant and Equipment [Abstract] | |
Summary of Property and Equipment | Property and equipment, net consisted of the following at December 31: (In thousands) 2022 2021 Laboratory equipment $ 23,182 $ 22,165 Computer equipment and software 6,179 6,913 Leasehold improvements 37,277 32,726 Furniture and fixtures 3,514 3,035 Office equipment 2,248 1,690 Construction in progress 657 7,368 Total property and equipment 73,057 73,897 Less: accumulated depreciation (50,070) (44,974) Total property and equipment, net $ 22,987 $ 28,923 |
Discontinued Operations and Dis
Discontinued Operations and Disposal Groups (Tables) | 12 Months Ended |
Dec. 31, 2022 | |
Discontinued Operations and Disposal Groups [Abstract] | |
Disposal Groups, Including Discontinued Operations | The following table presents the net liabilities transferred for the sale of the oncology business at March 31, 2021: (in thousands) March 31, 2021 Assets Current assets: Accounts receivable, net $ 25,386 Collaboration receivable – related party 2,253 Collaboration receivable – other 2,438 Inventory 16,190 Prepaid expenses and other current assets 7,125 Total current assets of discontinued operations 53,392 Other non-current assets 2,234 Total assets of discontinued operations $ 55,626 Liabilities Current liabilities: Accounts payable $ 4,245 Accrued expenses 30,288 Total current liabilities of discontinued operations 34,533 Liability related to the sale of future revenue, net of debt issuance costs 264,281 Total liabilities of discontinued operations 298,814 Net liabilities distributed to Servier $ (243,188) The following table presents the gain on the sale for the year ended December 31, 2021: (in thousands) December 31, 2021 Cash proceeds $ 1,802,936 Less: transaction and insurance costs (53,573) Plus: net liabilities distributed, including working capital adjustment 239,770 Gain on sale, pre-tax 1,989,133 Income tax expense (12,799) Gain on sale, net of tax $ 1,976,334 The following table presents the financial results of the discontinued operations: (in thousands) 2021 2020 Revenues: Product revenue, net $ 36,909 $ 121,089 Collaboration revenue – related party 1,350 68,274 Collaboration revenue – other 491 3,571 Royalty revenue – related party 2,659 10,262 Total revenue 41,409 203,196 Cost and expenses: Cost of sales 706 2,805 Research and development 41,564 146,659 Selling, general and administrative 8,551 33,965 Total cost and expenses 50,821 183,429 (Loss) income from discontinued operations (9,412) 19,767 Non-cash interest expense for the sale of future revenue (5,697) (17,832) Gain on the sale of the oncology business 1,989,133 — Income from discontinued operations, pre-tax 1,974,024 1,935 Income tax expense (12,799) — Net income from discontinued operations $ 1,961,225 $ 1,935 |
Nature of Business - Additional
Nature of Business - Additional Information (Details) $ / shares in Units, $ in Thousands | 12 Months Ended | 21 Months Ended | |||||||
Apr. 05, 2021 USD ($) $ / shares shares | Mar. 31, 2021 USD ($) | Dec. 31, 2022 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2022 USD ($) $ / shares shares | Apr. 02, 2021 USD ($) | Mar. 25, 2021 USD ($) | Apr. 30, 2020 USD ($) | |
Subsidiary, Sale of Stock [Line Items] | |||||||||
Royalty income from gain on sale of oncology business | $ 9,851 | $ 6,639 | $ 0 | ||||||
Gain on sale of contingent payments | 127,853 | 0 | $ 0 | ||||||
Stock repurchase program, authorized amount | $ 1,200,000 | ||||||||
Repurchase of common stock | 802,486 | ||||||||
Cash, cash equivalents and marketable securities | $ 1,100,000 | $ 1,100,000 | |||||||
Repurchase Program | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Stock repurchase program, authorized amount | $ 1,200,000 | ||||||||
Shares repurchased (in shares) | shares | 16,200,000 | ||||||||
Repurchase of common stock | $ 802,500 | ||||||||
Shares repurchased (in usd per share) | $ / shares | $ 49.49 | ||||||||
BMS Repurchase | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Shares repurchased (in shares) | shares | 7,100,000 | ||||||||
Repurchase of common stock | $ 344,500 | ||||||||
Shares repurchased (in usd per share) | $ / shares | $ 48.38 | ||||||||
Rule 10b5-1 Repurchase | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Stock repurchase program, authorized amount | $ 600,000 | ||||||||
Shares repurchased (in shares) | shares | 9,100,000 | ||||||||
Repurchase of common stock | $ 458,000 | ||||||||
Shares repurchased (in usd per share) | $ / shares | $ 50.35 | ||||||||
October 13 2021 Repurchase Program , Rule 10b-18 Repurchase | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Shares repurchased (in shares) | shares | 0 | ||||||||
Repurchase Program | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Shares repurchased (in shares) | shares | 16,200,000 | ||||||||
Repurchase of common stock | $ 802,500 | ||||||||
Shares repurchased (in usd per share) | $ / shares | $ 49.49 | ||||||||
U.S. | TIBSOVO | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Earn-out revenue for royalties | 6,600 | ||||||||
Discontinued Operations, Disposed of by Sale | Agios Oncology Business | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Cash proceeds | $ 1,800,000 | $ 1,802,936 | |||||||
Contingent milestone payment | $ 200,000 | ||||||||
Discontinued Operations, Disposed of by Sale | Agios Oncology Business | U.S. | TIBSOVO | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Contingent royalty payment | 0.05 | ||||||||
Discontinued Operations, Disposed of by Sale | Agios Oncology Business | U.S. | vorasidenib | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Contingent royalty payment | 0.15 | ||||||||
At-the-market Offering | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Maximum value of shares issued | $ 250,000 | ||||||||
Value of common stock reserved for future issuance | $ 250,000 | $ 250,000 | |||||||
2010 Agreement | |||||||||
Subsidiary, Sale of Stock [Line Items] | |||||||||
Milestone payment for achievement of specified ex-U.S. commercial milestone event | $ 25,000 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Additional Information (Details) | 12 Months Ended |
Dec. 31, 2022 segment | |
Schedule of Significant Accounting Policies [Line Items] | |
Minimum period to liquidate | 12 months |
Number of operating segments | 1 |
Minimum | |
Schedule of Significant Accounting Policies [Line Items] | |
Investment maturity period, non-current | 1 year |
Maximum | |
Schedule of Significant Accounting Policies [Line Items] | |
Investment maturity period, current | 1 year |
Investment maturity period, non-current | 2 years |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Estimated Useful Lives of Property and Equipment (Details) | 12 Months Ended |
Dec. 31, 2022 | |
Laboratory equipment | |
Property, Plant and Equipment [Line Items] | |
Estimated useful lives of property and equipment (in years) | 5 years |
Computer equipment and software | |
Property, Plant and Equipment [Line Items] | |
Estimated useful lives of property and equipment (in years) | 3 years |
Furniture and fixtures | |
Property, Plant and Equipment [Line Items] | |
Estimated useful lives of property and equipment (in years) | 5 years |
Office equipment | |
Property, Plant and Equipment [Line Items] | |
Estimated useful lives of property and equipment (in years) | 5 years |
Fair Value Measurements - Cash
Fair Value Measurements - Cash Equivalents and Marketable Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | $ 957,734 | $ 1,083,267 |
Fair Value, Measurements, Recurring | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 88,002 | |
Total marketable securities | 957,734 | |
Total cash equivalents and marketable securities | 1,045,736 | |
Fair Value, Measurements, Recurring | U.S. Treasuries | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 84,596 | |
Fair Value, Measurements, Recurring | Government securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 331,443 | |
Fair Value, Measurements, Recurring | Corporate debt securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 541,695 | |
Fair Value, Measurements, Recurring | Cash equivalents | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 88,002 | |
Fair Value, Measurements, Recurring | Level 1 | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 37,093 | |
Total marketable securities | 0 | |
Total cash equivalents and marketable securities | 37,093 | |
Fair Value, Measurements, Recurring | Level 1 | U.S. Treasuries | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 1 | Government securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 1 | Corporate debt securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 1 | Cash equivalents | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 37,093 | |
Fair Value, Measurements, Recurring | Level 2 | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 50,909 | |
Total marketable securities | 957,734 | |
Total cash equivalents and marketable securities | 1,008,643 | |
Fair Value, Measurements, Recurring | Level 2 | U.S. Treasuries | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 84,596 | |
Fair Value, Measurements, Recurring | Level 2 | Government securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 331,443 | |
Fair Value, Measurements, Recurring | Level 2 | Corporate debt securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 541,695 | |
Fair Value, Measurements, Recurring | Level 2 | Cash equivalents | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 50,909 | |
Fair Value, Measurements, Recurring | Level 3 | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | 0 | |
Total marketable securities | 0 | |
Total cash equivalents and marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 3 | U.S. Treasuries | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 3 | Government securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 3 | Corporate debt securities | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total marketable securities | 0 | |
Fair Value, Measurements, Recurring | Level 3 | Cash equivalents | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Total cash equivalents | $ 0 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Details) | Dec. 31, 2022 USD ($) |
Fair Value, Measurements, Recurring | Level 3 | |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |
Fair value of assets (liabilities) | $ 0 |
Marketable Securities - Summary
Marketable Securities - Summary of Marketable Securities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | $ 970,269 | $ 1,084,465 |
Unrealized Gains | 99 | 4 |
Unrealized Losses | (12,634) | (1,202) |
Fair Value | 957,734 | 1,083,267 |
Current: | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 652,339 | 817,363 |
Unrealized Gains | 12 | 4 |
Unrealized Losses | (8,491) | (475) |
Fair Value | 643,860 | 816,892 |
Current: | U.S. Treasuries | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 68,175 | 269,109 |
Unrealized Gains | 3 | 0 |
Unrealized Losses | (811) | (36) |
Fair Value | 67,367 | 269,073 |
Current: | Government securities | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 220,901 | 17,764 |
Unrealized Gains | 8 | 1 |
Unrealized Losses | (5,289) | (10) |
Fair Value | 215,620 | 17,755 |
Current: | Corporate debt securities | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 363,263 | 530,490 |
Unrealized Gains | 1 | 3 |
Unrealized Losses | (2,391) | (429) |
Fair Value | 360,873 | 530,064 |
Non-current: | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 317,930 | 267,102 |
Unrealized Gains | 87 | 0 |
Unrealized Losses | (4,143) | (727) |
Fair Value | 313,874 | 266,375 |
Non-current: | U.S. Treasuries | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 17,418 | 40,607 |
Unrealized Gains | 4 | 0 |
Unrealized Losses | (193) | (23) |
Fair Value | 17,229 | 40,584 |
Non-current: | Government securities | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 117,475 | 148,820 |
Unrealized Gains | 7 | 0 |
Unrealized Losses | (1,659) | (470) |
Fair Value | 115,823 | 148,350 |
Non-current: | Corporate debt securities | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 183,037 | 77,675 |
Unrealized Gains | 76 | 0 |
Unrealized Losses | (2,291) | (234) |
Fair Value | $ 180,822 | $ 77,441 |
Marketable Securities - Additio
Marketable Securities - Additional Information (Details) | 12 Months Ended | |
Dec. 31, 2022 USD ($) security | Dec. 31, 2021 USD ($) security | |
Investments, Debt and Equity Securities [Abstract] | ||
Realized gain (loss) on marketable securities | $ | $ 0 | $ 0 |
Number of debt securities in an unrealized loss position for less than one year | security | 259 | 294 |
Aggregate fair value of debt securities in an unrealized loss position | $ | $ 868,200,000 | $ 950,500,000 |
Number of unrealized loss position | security | 0 | 0 |
Inventory - Schedule of Invento
Inventory - Schedule of Inventory (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Inventory Disclosure [Abstract] | ||
Raw materials | $ 0 | $ 0 |
Work-in-process | 7,550 | 0 |
Finished goods | 942 | 0 |
Total inventory | $ 8,492 | $ 0 |
Leases - Additional Information
Leases - Additional Information (Details) ft² in Thousands, $ in Millions | 12 Months Ended | ||||
Apr. 11, 2019 USD ($) ft² leaseTerm | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Apr. 30, 2022 ft² | Aug. 31, 2021 ft² | |
Lessee, Lease, Description [Line Items] | |||||
Remaining lease terms | 5 years | ||||
Weighted-average incremental borrowing rate | 5.70% | 5.70% | |||
Weighted-average remaining lease term | 5 years 2 months 12 days | 6 years 2 months 12 days | |||
Standby letter of credit | $ 2.9 | ||||
38 Sidney Street Lease | |||||
Lessee, Lease, Description [Line Items] | |||||
Number of square feet of office space (in square feet) | ft² | 13 | ||||
Number of optional terms available at end of current lease term (in lease terms) | leaseTerm | 2 | ||||
Term for extension of operating lease (in years) | 5 years | ||||
Tenant improvement allowance | $ 1 | ||||
Area of premises subleased (in square feet) | ft² | 27 | 13 | |||
Sublease income | 4.1 | $ 0.5 | |||
38 Sidney Street Lease | Other Noncurrent Assets | |||||
Lessee, Lease, Description [Line Items] | |||||
Security deposit liability | $ 1.1 | ||||
64 Sidney Street Lease | |||||
Lessee, Lease, Description [Line Items] | |||||
Term for extension of operating lease (in years) | 3 years | ||||
88 Sidney Street Lease | |||||
Lessee, Lease, Description [Line Items] | |||||
Term for extension of operating lease (in years) | 3 years |
Leases - Schedule of Lease Cost
Leases - Schedule of Lease Cost and Other Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Leases [Abstract] | |||
Operating lease costs | $ 15,227 | $ 15,229 | $ 15,241 |
Cash paid for amounts included in the measurement of operating lease liabilities | $ 17,035 | $ 14,411 | $ 14,424 |
Leases - Schedule of Undiscount
Leases - Schedule of Undiscounted Minimum Rental Commitments (Details) $ in Thousands | Dec. 31, 2022 USD ($) |
Leases [Abstract] | |
2023 | $ 16,651 |
2024 | 18,660 |
2025 | 19,507 |
2026 | 20,151 |
2027 | 20,755 |
Thereafter | 3,479 |
Undiscounted minimum rental commitments | 99,203 |
Interest | (13,544) |
Total operating lease liabilities | $ 85,659 |
Leases - Schedule of Future Min
Leases - Schedule of Future Minimum Lease Payments to be Received (Details) $ in Thousands | Dec. 31, 2022 USD ($) |
Leases [Abstract] | |
2023 | $ 4,329 |
2024 | 4,459 |
2025 | 1,101 |
Total | $ 9,889 |
Accrued Expenses - Summary of A
Accrued Expenses - Summary of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Payables and Accruals [Abstract] | ||
Accrued compensation | $ 18,105 | $ 19,818 |
Accrued research and development costs | 8,425 | 5,980 |
Accrued professional fees | 2,435 | 2,335 |
Accrued other | 1,385 | 3,834 |
Total accrued expenses | $ 30,350 | $ 31,967 |
Product Revenue - Schedule of P
Product Revenue - Schedule of Product Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Disaggregation of Revenue [Line Items] | |||
Total revenue | $ 14,240 | $ 0 | $ 0 |
Product revenue, net | |||
Disaggregation of Revenue [Line Items] | |||
Total revenue | $ 11,740 | $ 0 | $ 0 |
Product Revenue - Schedule of_2
Product Revenue - Schedule of Product Revenue Allowance and Reserves (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2022 | Dec. 31, 2021 | |
Contractual Adjustments | ||
Contractual adjustments, beginning balance | $ 0 | |
Contractual adjustments, current provisions relating to sales in the current year | 497 | |
Contractual adjustments, adjustments relating to prior years | 0 | |
Contractual adjustments, payments/returns relating to sales in the current year | (432) | |
Contractual adjustments, payments/returns relating to sales in the prior year | 0 | |
Contractual adjustments, ending balance | 65 | |
Government Rebates [Roll Forward] | ||
Government rebates, beginning balance | 0 | |
Government rebates, current provisions relating to sales in the current year | 912 | |
Government rebates, adjustments relating to prior years | 0 | |
Government rebates, payments/returns relating to sales in the current year | (339) | |
Government rebates, payments/returns relating to sales in the prior years | 0 | |
Government rebates, ending balance | 573 | |
Returns | ||
Returns, beginning balance | 0 | |
Returns, current provisions relating to sales in the current year | 133 | |
Returns, adjustments relating to prior years | 0 | |
Returns, payments/returns relating to sales in the current year | ||
Returns, payments/returns relating to sales in the prior years | 0 | |
Returns, ending balance | 133 | |
Total | ||
Total revenue-related reserves | 771 | $ 0 |
Total allowances and reserves, current provisions relating to sales in the current year | 1,542 | |
Total allowances and reserves, adjustments relating to prior years | 0 | |
Total allowances and reserves, payments/returns relating to sales in the current year | (771) | |
Total allowances and reserves, payments/returns relating to sales in the prior years | $ 0 |
Product Revenue - Schedule of R
Product Revenue - Schedule of Revenue-Related Reserves (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Revenue from Contract with Customer [Abstract] | ||
Reduction of accounts receivable | $ 60 | $ 0 |
Component of accrued expenses | 711 | 0 |
Total revenue-related reserves | $ 771 | $ 0 |
Product Revenue - Schedule of C
Product Revenue - Schedule of Changes in Contract Assets (Details) | 12 Months Ended |
Dec. 31, 2022 USD ($) | |
Contract Assets and Liabilities [Roll Forward] | |
Contract assets, beginning balance | $ 0 |
Additions | 13,283,000 |
Deductions | (11,077,000) |
Contract assets, ending balance | $ 2,206,000 |
Product Revenue - Additional In
Product Revenue - Additional Information (Details) - USD ($) | Dec. 31, 2022 | Dec. 31, 2021 |
Revenue from Contract with Customer [Abstract] | ||
Contract assets | $ 2,206,000 | $ 0 |
Share-Based Payments - Addition
Share-Based Payments - Additional Information (Details) - USD ($) | 12 Months Ended | ||||
Jan. 03, 2023 | Jan. 01, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Tax benefits related to stock based compensation | $ 0 | $ 0 | $ 0 | ||
Expected contractual term | 10 years | ||||
Expected dividend yield | 0% | 0% | 0% | ||
Restricted stock units | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Weighted-average period to recognize compensation expense | 1 year 9 months 3 days | ||||
Unrecognized compensation expense excluding options | $ 25,600,000 | ||||
Performance-based stock units | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Unrecognized compensation expense excluding options | 0 | ||||
Unrecognized compensation cost not expected to be recognized | 15,400,000 | ||||
Market-based stock units | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Unrecognized compensation expense excluding options | $ 0 | ||||
2007 Plan and 2013 Plan | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Share based awards reserved for issuance (in shares) | 12,821,789 | ||||
2013 Stock Incentive Plan | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Shares available for future issuance (in shares) | 5,458,366 | ||||
Annual increase in common stock (in shares) | 2,000,000 | ||||
Percentage of outstanding shares of common stock | 4% | ||||
Weighted-average grant date fair value of options (in usd per share) | $ 15.64 | $ 31.2 | $ 32.1 | ||
Intrinsic value of options exercised | $ 300,000 | $ 8,500,000 | $ 10,400,000 | ||
Unrecognized compensation expense related to options | $ 38,100,000 | ||||
Weighted-average period to recognize compensation expense | 2 years 8 months 15 days | ||||
2013 Stock Incentive Plan | Subsequent Event | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Additional shares authorized for issuance (in shares) | 2,000,000 | ||||
2013 Employee Stock Purchase Plan | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Shares available for future issuance (in shares) | 1,289,780 | ||||
Shares issued under 2013 ESPP (in shares) | 104,867 | 94,888 | |||
Opportunity to purchase common stock (in shares) | 1,854,545 | ||||
2013 Employee Stock Purchase Plan | Subsequent Event | |||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||
Additional shares authorized for issuance (in shares) | 509,091 |
Share-Based Payments - Summary
Share-Based Payments - Summary of Company's Stock Option Activity of all Stock Incentive Plans (Details) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended | |
Dec. 31, 2022 | Dec. 31, 2021 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] | ||
Number of stock options, outstanding, beginning balance (in shares) | 4,798,826 | |
Number of stock options, granted (in shares) | 1,850,093 | |
Number of stock options, exercised (in shares) | (15,539) | |
Number of stock options, forfeited/expired (in shares) | (860,816) | |
Number of stock options, outstanding, ending balance (in shares) | 5,772,564 | 4,798,826 |
Number of stock options, exercisable (in shares) | 3,497,660 | |
Number of stock options, vested and expected to vest (in shares) | 5,772,564 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] | ||
Weighted-average exercise price, outstanding, beginning balance (in usd per share) | $ 58.51 | |
Weighted-average exercise price, granted (in usd per share) | 28.89 | |
Weighted-average exercise price, exercised (in usd per share) | 11.50 | |
Weighted-average exercise price, forfeited/expired (in usd per share) | 60.91 | |
Weighted-average exercise price, outstanding, ending balance (in usd per share) | 48.81 | $ 58.51 |
Weighted-average exercise price, exercisable (in usd per share) | 58.24 | |
Weighted-average exercise price, vested and expected to vest (in usd per share) | $ 48.81 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] | ||
Weighted-average remaining contractual term, outstanding (in years) | 6 years 6 months | 6 years 2 months 26 days |
Weighted-average remaining contractual term, exercisable (in years) | 4 years 10 months 2 days | |
Weighted-average remaining contractual term, vested and expected to vest (in years) | 6 years 6 months | |
Aggregate intrinsic value, outstanding | $ 5,362 | $ 4,697 |
Aggregate intrinsic value, exercisable | 3,141 | |
Aggregate intrinsic value, vested and expected to vest | $ 5,362 |
Share-Based Payments - Summar_2
Share-Based Payments - Summary of Unvested RSUs, Performance-Based Stock and Market-Based Stock Unit Activity (Details) | 12 Months Ended |
Dec. 31, 2022 $ / shares shares | |
Restricted stock units | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] | |
Unvested shares beginning of period (in shares) | shares | 1,002,924 |
Granted (in shares) | shares | 869,766 |
Vested (in shares) | shares | (531,304) |
Forfeited (in shares) | shares | (223,465) |
Unvested shares end of period (in shares) | shares | 1,117,921 |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] | |
Weighted-average grant date fair value, unvested shares beginning of period (in usd per share) | $ / shares | $ 51.51 |
Weighted-average grant date fair value, granted (in usd per share) | $ / shares | 31.16 |
Weighted-average grant date fair value, vested (in usd per share) | $ / shares | 50.16 |
Weighted-average grant date fair value, forfeited (in usd per share) | $ / shares | 41.84 |
Weighted-average grant date fair value, unvested shares end of period (in usd per share) | $ / shares | $ 38.30 |
Performance-based stock units | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] | |
Unvested shares beginning of period (in shares) | shares | 234,059 |
Granted (in shares) | shares | 337,243 |
Vested (in shares) | shares | (53,777) |
Forfeited (in shares) | shares | (47,190) |
Expired (in shares) | shares | (40,092) |
Unvested shares end of period (in shares) | shares | 430,243 |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] | |
Weighted-average grant date fair value, unvested shares beginning of period (in usd per share) | $ / shares | $ 54.28 |
Weighted-average grant date fair value, granted (in usd per share) | $ / shares | 30.33 |
Weighted-average grant date fair value, vested (in usd per share) | $ / shares | 54.28 |
Weighted-average grant date fair value, forfeited (in usd per share) | $ / shares | 49.06 |
Weighted-average grant date fair value, expired (in usd per share) | $ / shares | 56.52 |
Weighted-average grant date fair value, unvested shares end of period (in usd per share) | $ / shares | $ 35.87 |
Market-based stock units | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] | |
Unvested shares beginning of period (in shares) | shares | 42,695 |
Granted (in shares) | shares | 0 |
Unvested shares end of period (in shares) | shares | 42,695 |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] | |
Weighted-average grant date fair value, unvested shares beginning of period (in usd per share) | $ / shares | $ 41.50 |
Weighted-average grant date fair value, granted (in usd per share) | $ / shares | 0 |
Weighted-average grant date fair value, unvested shares end of period (in usd per share) | $ / shares | $ 41.50 |
Share-Based Payments - Schedule
Share-Based Payments - Schedule of Stock-Based Compensation by Award Type Included Within the Consolidated Statements of Operations (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | $ 49,296 | $ 53,508 | $ 61,602 |
Stock options | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | 23,731 | 30,985 | 37,705 |
Restricted stock units | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | 21,670 | 21,510 | 19,893 |
Performance-based stock units | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | 2,919 | 0 | 1,760 |
Employee Stock Purchase Plan | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | 976 | 1,013 | 1,463 |
Other stock awards | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Total stock-based compensation expense | $ 0 | $ 0 | $ 781 |
Share-Based Payments - Stock-Ba
Share-Based Payments - Stock-Based Compensation Expense for Equity-Based Awards (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Allocated share based compensation expense | $ 49,296 | $ 53,508 | $ 61,602 |
Research and development expense | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Allocated share based compensation expense | 20,988 | 24,527 | 27,119 |
Selling, general and administrative expense | |||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Allocated share based compensation expense | $ 28,308 | $ 28,981 | $ 34,483 |
Share-Based Payments - Schedu_2
Share-Based Payments - Schedule of Grant Date Fair Value Option Award Weighted Average Assumptions Used (Details) | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Share-Based Payment Arrangement [Abstract] | |||
Risk-free interest rate | 2.55% | 0.72% | 1.24% |
Expected dividend yield | 0% | 0% | 0% |
Expected term (in years) | 6 years 10 days | 6 years 18 days | 6 years 18 days |
Expected volatility | 55.30% | 61.72% | 73.80% |
Net Income (Loss) per Share - C
Net Income (Loss) per Share - Common Stock Excluded from Calculation of Diluted Net Loss Per Share (Detail) - shares | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share (in shares) | 6,932,511 | 5,841,614 | 7,473,863 |
Stock options | |||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share (in shares) | 5,772,564 | 4,798,826 | 6,143,046 |
Restricted stock units | |||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share (in shares) | 1,117,921 | 1,002,924 | 1,284,378 |
Employee Stock Purchase Plan shares | |||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share (in shares) | 42,026 | 39,864 | 46,439 |
Income Taxes - Schedule of Dome
Income Taxes - Schedule of Domestic and Foreign Components of Loss Before Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Income Tax Disclosure [Abstract] | |||
Domestic | $ (231,767) | $ (356,665) | $ (330,669) |
Foreign | (34) | 155 | 1,364 |
Net loss from continuing operations | $ (231,801) | $ (356,510) | $ (329,305) |
Income Taxes - Reconciliation o
Income Taxes - Reconciliation of Expected Income Tax Benefit (Expense) Computed Using Federal Statutory Income Tax Rate (Details) | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Income Tax Disclosure [Abstract] | |||
Income tax benefit computed at federal statutory tax rate | 21% | 21% | 21% |
State taxes, net of federal benefit | 2.90% | 2.60% | 2.50% |
Change in valuation allowance | (25.70%) | (24.50%) | (28.20%) |
General business credits and other credits | 5.20% | 5.30% | 7% |
Permanent differences and other adjustments | (2.30%) | (3.90%) | (1.60%) |
Stock based compensation | (1.10%) | (0.50%) | (0.70%) |
Total | 0% | 0% | 0% |
Income Taxes - Components of De
Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 |
Deferred tax assets: | |||
Net operating loss carryforwards | $ 32,907 | $ 39,186 | |
Tax credit carryforwards | 163,780 | 152,128 | |
Purchased intangible assets | 11,583 | 12,150 | |
Stock-based compensation | 26,236 | 27,217 | |
Operating lease liability | 21,042 | 22,963 | |
Non-deductible accruals and reserves, including inventory | 3,992 | 4,033 | |
Section 174 R&D expense | 56,565 | 0 | |
Total deferred tax assets | 316,105 | 257,677 | |
Depreciation and amortization | (3,767) | (3,168) | |
Operating lease right of use asset | (16,345) | (18,031) | |
Less: valuation allowance | (295,993) | (236,478) | $ (594,752) |
Net deferred taxes | $ 0 | $ 0 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Details) | 12 Months Ended | ||
Dec. 31, 2022 USD ($) audit | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | |
Income Taxes Disclosure [Line Items] | |||
Capitalized research and development costs | $ 261,400,000 | ||
Percentage of stock owned resulting in an ownership change | 50% | ||
Aggregate period | 3 years | ||
Valuation allowance | $ 295,993,000 | $ 236,478,000 | $ 594,752,000 |
Increase (decrease) for the current period | 59,515,000 | (358,274,000) | |
Accrued interest and penalties related to uncertain tax positions | 0 | 0 | |
Unrecognized tax benefits | $ 26,190,000 | 24,220,000 | $ 21,131,000 |
Number of federal, state or foreign audits in process | audit | 0 | ||
U.S. | |||
Income Taxes Disclosure [Line Items] | |||
Capitalized research and development costs, amortization period | 5 years | ||
Non-US | |||
Income Taxes Disclosure [Line Items] | |||
Capitalized research and development costs, amortization period | 15 years | ||
Prepaid Expenses and Other Current Assets | |||
Income Taxes Disclosure [Line Items] | |||
Income tax receivable | $ 300,000 | $ 2,900,000 | |
Federal Orphan Drug Tax Credit | |||
Income Taxes Disclosure [Line Items] | |||
Research and development tax credit | 126,500,000 | ||
State and Local Jurisdiction | |||
Income Taxes Disclosure [Line Items] | |||
Net operating loss carryforwards | 1,200,000,000 | ||
State and Local Jurisdiction | Research Tax Credit Carryforward | |||
Income Taxes Disclosure [Line Items] | |||
Research and development tax credit | 25,700,000 | ||
Foreign Income Tax | |||
Income Taxes Disclosure [Line Items] | |||
Net operating loss carryforwards | 65,200,000 | ||
Federal | Research Tax Credit Carryforward | |||
Income Taxes Disclosure [Line Items] | |||
Research and development tax credit | $ 16,900,000 |
Income Taxes - Changes in Valua
Income Taxes - Changes in Valuation Allowance (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2022 | Dec. 31, 2021 | |
Deferred Tax Assets, Valuation Allowance [Roll Forward] | ||
Valuation allowance at the beginning of the year | $ 236,478 | $ 594,752 |
Increase (decrease) for the current period | 59,515 | (358,274) |
Valuation allowance at the end of the year | $ 295,993 | $ 236,478 |
Income Taxes - Unrecognized Tax
Income Taxes - Unrecognized Tax Benefits Rollforward (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2022 | Dec. 31, 2021 | |
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] | ||
Unrecognized tax benefits at the beginning of the year | $ 24,220 | $ 21,131 |
Gross increases - current period tax positions | 1,970 | 3,089 |
Unrecognized tax benefits at the end of the year | $ 26,190 | $ 24,220 |
Property and Equipment, net - S
Property and Equipment, net - Summary of Property and Equipment (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 |
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | $ 73,057 | $ 73,897 |
Less: accumulated depreciation | (50,070) | (44,974) |
Property and equipment, net | 22,987 | 28,923 |
Laboratory equipment | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | 23,182 | 22,165 |
Computer equipment and software | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | 6,179 | 6,913 |
Leasehold improvements | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | 37,277 | 32,726 |
Furniture and fixtures | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | 3,514 | 3,035 |
Office equipment | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | 2,248 | 1,690 |
Construction in progress | ||
Property, Plant and Equipment [Line Items] | ||
Total property and equipment | $ 657 | $ 7,368 |
Property and Equipment, net - A
Property and Equipment, net - Additional Information (Details) - USD ($) $ in Millions | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Property, Plant and Equipment [Abstract] | |||
Depreciation expense | $ 8.4 | $ 8.8 | $ 9.4 |
Common Stock - Additional Infor
Common Stock - Additional Information (Details) | Dec. 31, 2022 vote shares | Dec. 31, 2021 vote shares |
Equity [Abstract] | ||
Common stock, shares authorized (in shares) | shares | 125,000,000 | 125,000,000 |
Number of votes per share | vote | 1 | 1 |
Share Repurchase Program (Detai
Share Repurchase Program (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions | 12 Months Ended | 21 Months Ended | ||||
Apr. 05, 2021 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2022 | Apr. 02, 2021 | Mar. 25, 2021 | |
Equity, Class of Treasury Stock [Line Items] | ||||||
Stock repurchase program, authorized amount | $ 1,200,000 | |||||
Repurchase of common stock | $ 802,486 | |||||
Repurchase Program | ||||||
Equity, Class of Treasury Stock [Line Items] | ||||||
Stock repurchase program, authorized amount | $ 1,200,000 | |||||
Shares repurchased (in shares) | 16.2 | |||||
Repurchase of common stock | $ 802,500 | |||||
Shares repurchased (in usd per share) | $ 49.49 | |||||
BMS Repurchase | ||||||
Equity, Class of Treasury Stock [Line Items] | ||||||
Shares repurchased (in shares) | 7.1 | |||||
Repurchase of common stock | $ 344,500 | |||||
Shares repurchased (in usd per share) | $ 48.38 | |||||
Rule 10b5-1 Repurchase | ||||||
Equity, Class of Treasury Stock [Line Items] | ||||||
Stock repurchase program, authorized amount | $ 600,000 | |||||
Shares repurchased (in shares) | 9.1 | |||||
Repurchase of common stock | $ 458,000 | |||||
Shares repurchased (in usd per share) | $ 50.35 |
Discontinued Operations - Asset
Discontinued Operations - Assets and Liabilities of Discontinued Operations (Details) - Agios Oncology Business - Discontinued Operations, Disposed of by Sale - USD ($) | 12 Months Ended | ||
Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2022 | |
Current assets: | |||
Accounts receivable, net | $ 25,386,000 | ||
Collaboration receivable – related party | 2,253,000 | ||
Collaboration receivable – other | 2,438,000 | ||
Inventory | 16,190,000 | ||
Prepaid expenses and other current assets | 7,125,000 | ||
Total current assets of discontinued operations | 53,392,000 | ||
Other non-current assets | 2,234,000 | ||
Total assets of discontinued operations | 55,626,000 | $ 0 | $ 0 |
Current liabilities: | |||
Accounts payable | 4,245,000 | ||
Accrued expenses | 30,288,000 | ||
Total current liabilities of discontinued operations | 34,533,000 | ||
Liability related to the sale of future revenue, net of debt issuance costs | 264,281,000 | ||
Total liabilities of discontinued operations | 298,814,000 | 0 | $ 0 |
Net liabilities distributed to Servier | $ (243,188,000) | $ (239,770,000) |
Discontinued Operations - Summa
Discontinued Operations - Summary of Gain on Sale of Discontinued Operations (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | |
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] | |||
Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration] | Less: Net income from discontinued operations | ||
Agios Oncology Business | Discontinued Operations, Disposed of by Sale | |||
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] | |||
Cash proceeds | $ 1,800,000 | $ 1,802,936 | |
Less: transaction and insurance costs | (53,573) | ||
Plus: net liabilities distributed, including working capital adjustment | $ 243,188 | 239,770 | |
Gain on sale, pre-tax | 1,989,133 | $ 0 | |
Income tax expense | (12,799) | $ 0 | |
Gain on sale, net of tax | $ 1,976,334 |
Discontinued Operations - Addit
Discontinued Operations - Additional Information (Details) - USD ($) | 12 Months Ended | |||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Mar. 31, 2021 | |
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] | ||||
Gain on sale of contingent payments | $ 127,853,000 | $ 0 | $ 0 | |
Agios Oncology Business | Discontinued Operations, Disposed of by Sale | ||||
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] | ||||
Total assets of discontinued operations | 0 | 0 | $ 55,626,000 | |
Total liabilities of discontinued operations | $ 0 | $ 0 | $ 298,814,000 |
Discontinued Operations - Finan
Discontinued Operations - Financial Results of Discontinued Operations (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
Cost and expenses: | |||
Net income from discontinued operations | $ 0 | $ 1,961,225 | $ 1,935 |
Agios Oncology Business | Discontinued Operations, Disposed of by Sale | |||
Revenues: | |||
Total revenue | 41,409 | 203,196 | |
Cost and expenses: | |||
Cost of sales | 706 | 2,805 | |
Research and development | 41,564 | 146,659 | |
Selling, general and administrative | 8,551 | 33,965 | |
Total cost and expenses | 50,821 | 183,429 | |
(Loss) income from discontinued operations | (9,412) | 19,767 | |
Non-cash interest expense for the sale of future revenue | (5,697) | (17,832) | |
Gain on the sale of the oncology business | 1,989,133 | 0 | |
Income from discontinued operations, pre-tax | 1,974,024 | 1,935 | |
Income tax expense | (12,799) | 0 | |
Net income from discontinued operations | 1,961,225 | 1,935 | |
Agios Oncology Business | Product revenue, net | Discontinued Operations, Disposed of by Sale | |||
Revenues: | |||
Total revenue | 36,909 | 121,089 | |
Agios Oncology Business | Collaboration revenue – related party | Discontinued Operations, Disposed of by Sale | |||
Revenues: | |||
Total revenue | 1,350 | 68,274 | |
Agios Oncology Business | Collaboration revenue – other | Discontinued Operations, Disposed of by Sale | |||
Revenues: | |||
Total revenue | 491 | 3,571 | |
Agios Oncology Business | Milestone revenue | Discontinued Operations, Disposed of by Sale | |||
Revenues: | |||
Total revenue | $ 2,659 | $ 10,262 |
Commitments and Contingent Li_2
Commitments and Contingent Liabilities - Additional Information (Details) | Dec. 31, 2022 lawsuit |
Commitments and Contingencies Disclosure [Abstract] | |
Number of ongoing legal proceedings | 0 |
Defined Contribution Benefit _2
Defined Contribution Benefit Plan - Additional Information (Details) | 12 Months Ended |
Dec. 31, 2022 | |
Retirement Benefits [Abstract] | |
Employer's matching contribution percentage | 100% |
Employer's contribution percentage of eligible compensation | 4% |