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RTW Investments

Filed: 15 Nov 21, 4:46pm

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X GENOMICS INCCL A COM88025U109106,926734,481SH SOLE1,2,3734,48100
5 01 ACQUISITION CORPCOM CL A33836P1053,849392,000SH SOLE1,2,3392,00000
908 DEVICES INCCOM65443P1021,30140,000SH SOLE1,2,340,00000
AADI BIOSCIENCES INCCOM00032Q10421,336764,701SH SOLE1,2,3764,70100
ACUTUS MED INCCOM0051111094,348491,834SH SOLE1,2,3491,83400
ADVERUM BIOTECHNOLOGIES INCCOM00773U10816,2407,483,757SH SOLE1,2,37,483,75700
AGENUS INCCOM NEW00847G70547,6419,074,438SH SOLE1,2,39,074,43800
AKOYA BIOSCIENCES INCCOM00974H1041,396100,000SH SOLE1,2,3100,00000
ALNYLAM PHARMACEUTICALS INCCOM02043Q107317,8361,683,362SH SOLE1,2,31,683,36200
APTEVO THERAPEUTICS INCCOM NEW03835L2074,345281,402SH SOLE1,2,3281,40200
APYX MEDICAL CORPORATIONCOM03837C10647,0663,398,279SH SOLE1,2,33,398,27900
ARBUTUS BIOPHARMA CORPCOM03879J10020,3064,733,323SH SOLE1,2,34,733,32300
ARGENX SESPONSORED ADR04016X10142,374140,311SH SOLE1,2,3140,31100
ARYA SCIENCES ACQU CORP IVCL AG316591085,025500,000SH SOLE1,2,3500,00000
ARYA SCIENCES ACQUISITN CORPCLASS A ORD SHSG316581004,940500,000SH SOLE1,2,3500,00000
ASLAN PHARMACEUTICALS LTDADS04522R1015,7853,250,000SH SOLE1,2,33,250,00000
ATHIRA PHARMA INCCOM04746L10417,8841,906,557SH SOLE1,2,31,906,55700
AVADEL PHARMACEUTICALS PLCSPONSORED ADR05337M10456,2715,741,939SH SOLE1,2,35,741,93900
AVIDITY BIOSCIENCES INCCOM05370A108118,1014,795,000SH SOLE1,2,34,795,00000
AVITA MEDICAL INCCOM05380C1024,962280,000SH SOLE1,2,3280,00000
AXONICS INCCOM05465P101126,5261,943,864SH SOLE1,2,31,943,86400
AXSOME THERAPEUTICS INCCOM05464T10453,2801,616,497SH SOLE1,2,31,616,49700
BCLS ACQUISITION CORPCOM CL AG0904B1056,101612,500SH SOLE1,2,3612,50000
BELLUS HEALTH INC NEWCOM NEW07987C20430,4314,968,017SH SOLE1,2,34,968,01700
BERKELEY LTS INCCOM0843101015,038257,546SH SOLE1,2,3257,54600
BIOMEA FUSION INCCOM09077A1069,877830,794SH SOLE1,2,3830,79400
BOLT BIOTHERAPEUTICS INCCOM0977021041,599126,365SH SOLE1,2,3126,36500
BRAINSWAY LTDSPONSORED ADS10501L10612,9151,602,381SH SOLE1,2,31,602,38100
BURNING ROCK BIOTECH LTDSPONSORED ADS12233L10753630,000SH SOLE1,2,330,00000
C4 THERAPEUTICS INCCOM STK12529R107111,4752,494,965SH SOLE1,2,32,494,96500
CASTLE BIOSCIENCES INCCOM14843C10539,834599,009SH SOLE1,2,3599,00900
CELLDEX THERAPEUTICS INC NEWCOM NEW15117B202211,0443,908,947SH SOLE1,2,33,908,94700
CEREVEL THERAPEUTICS HLDNG ICOM15678U12819,667666,666SH SOLE1,2,3666,66600
CLEARSIDE BIOMEDICAL INCCOM18506310425,2414,206,765SH SOLE1,2,34,206,76500
CODEX DNA INCCOM1920031012,226200,000SH SOLE1,2,3200,00000
CONNECT BIOPHARMA HLDGS LTDADS20752310110,904450,000SH SOLE1,2,3450,00000
CUTERA INCCOM23210910858,6161,257,862SH SOLE1,2,31,257,86200
CVRX INCCOM1266381052,481150,000SH SOLE1,2,3150,00000
CYTOKINETICS INCCOM NEW23282W60571,4802,000,000SH SOLE1,2,32,000,00000
CYTOMX THERAPEUTICS INCCOM23284F1057,1311,400,939SH SOLE1,2,31,400,93900
DERMTECH INCCOM24984K105100,1403,118,665SH SOLE1,2,33,118,66500
DICERNA PHARMACEUTICALS INCCOM253031108152,8617,582,396SH SOLE1,2,37,582,39600
ESSA PHARMA INCCOM NEW29668H70821,0982,637,192SH SOLE1,2,32,637,19200
ESTABLISHMENT LABS HLDGS INCCOMG31249108166,0042,319,138SH SOLE1,2,32,319,13800
EXAGEN INCCOM30068X10311,171821,414SH SOLE1,2,3821,41400
FULCRUM THERAPEUTICS INCCOM359616109108,7583,855,291SH SOLE1,2,33,855,29100
GENETRON HLDGS LTDADS37186H10023,1561,671,894SH SOLE1,2,31,671,89400
GH RESEARCH PLCORDINARY SHARESG3855L10645,7192,168,957SH SOLE1,2,32,168,95700
GLOBUS MED INCCL A379577208128,0181,670,811SH SOLE1,2,31,670,81100
GUARDANT HEALTH INCCOM40131M109115,677925,342SH SOLE1,2,3925,34200
HELIX ACQUISITION CORPCOM CL AG4444C1027,388750,000SH SOLE1,2,3750,00000
IDEAYA BIOSCIENCES INCCOM45166A10283,2573,266,255SH SOLE1,2,33,266,25500
ILLUMINA INCCOM452327109195,825482,791SH SOLE1,2,3482,79100
IMMATICS N.VSHSN444451094,550350,000SH SOLE1,2,3350,00000
IMMUNIC INCCOM4525EP10112,1321,370,814SH SOLE1,2,31,370,81400
IMMUNOCORE HLDGS PLCADS45258D10546,1721,245,532SH SOLE1,2,31,245,53200
INMODE LTDSHSM5425M10319,931124,999SH SOLE1,2124,99900
ITEOS THERAPEUTICS INCCOM46565G10463,5312,353,015SH SOLE1,2,32,353,01500
IVERIC BIO INCCOM46583P102109,1756,722,624SH SOLE1,2,36,722,62400
JOHNSON & JOHNSONCOM47816010427,543170,542SH SOLE1,2,3170,54200
JOUNCE THERAPEUTICS INCCOM48111610110,3741,396,203SH SOLE1,2,31,396,20300
LA JOLLA PHARMACEUTICAL COCOM PAR $.0001 25034596049,2882,327,903SH SOLE1,2,32,327,90300
LANDOS BIOPHARMA INCCOM51506910262,4264,275,722SH SOLE1,2,34,275,72200
LIFESCI ACQUISITION II CORPCOM53229E1039,555975,000SH SOLE1,2,3975,00000
MACROGENICS INCCOM55609910983,2483,975,554SH SOLE1,2,33,975,55400
MASIMO CORPCOM574795100225,377832,540SH SOLE1,2,3832,54000
MAXCYTE INCCOM57777K1063,358275,000SH SOLE1,2,3275,00000
MEDICUS SCIENCES ACQUISITION*W EXP 02/12/202G5960S1242433,331SH SOLE1,2,333,33100
MEDICUS SCIENCES ACQUISITIONCL A SHSG5960S1082,925300,000SH SOLE1,2,3300,00000
MILESTONE PHARMACEUTICALS INCOM59935V10724,6394,315,102SH SOLE1,2,34,315,10200
MIMEDX GROUP INCCOM6024961011,792295,748SH SOLE1,2,3295,74800
MIRATI THERAPEUTICS INCCOM60468T105264,0441,492,532SH SOLE1,2,31,492,53200
MIROMATRIX MED INCCOM60471P1081,949280,000SH SOLE1,2,3280,00000
MONTE ROSA THERAPEUTICS INCCOM61225M10226,0051,214,572SH SOLE1,2,31,214,57200
MONTES ARCHIMEDES ACQUISITIOCOM CL A6126571063,160400,000SH SOLE1,2,3400,00000
NANOSTRING TECHNOLOGIES INCCOM63009R10938,601804,029SH SOLE1,2,3804,02900
NATERA INCCOM632307104207,5271,862,234SH SOLE1,2,31,862,23400
NAUTILUS BIOTECHNOLOGY INCCOM63909J1086,5881,100,000SH SOLE1,2,31,100,00000
NEOGENOMICS INCCOM NEW64049M20914,873311,111SH SOLE1,2,3311,11100
NYXOAH S ASHSB6S7WD10610,087344,911SH SOLE1,2,3344,91100
OLINK HLDG ABSPONSORED ADS68071010031,9661,318,188SH SOLE1,2,31,318,18800
ORASURE TECHNOLOGIES INCCOM68554V10813,2861,174,722SH SOLE1,2,31,174,72200
OUTSET MED INCCOM69014510744,232894,652SH SOLE1,2,3894,65200
OYSTER PT PHARMA INCCOM69242L10622,0551,861,209SH SOLE1,2,31,861,20900
PENUMBRA INCCOM70975L107102,654385,194SH SOLE1,2,3385,19400
PMV PHARMACEUTICALS INCCOM69353Y10324,134809,863SH SOLE1,2,3809,86300
POINT BIOPHARMA GLOBAL INCCOM7305411093,768490,000SH SOLE1,2,3490,00000
PROCEPT BIOROBOTICS CORPCOM74276L1057,406194,136SH SOLE1,2,3194,13600
PROFOUND MED CORPCOM NEW74319B5021,788122,098SH SOLE1,2,3122,09800
PROMETHEUS BIOSCIENCES INCCOM74349U10877,3903,264,031SH SOLE1,2,33,264,03100
PROQR THRAPEUTICS N VSHS EURON7154210953,9296,443,113SH SOLE1,2,36,443,11300
PROTAGONIST THERAPEUTICS INCCOM74366E10231,0751,753,695SH SOLE1,2,31,753,69500
PTC THERAPEUTICS INCCOM69366J200196,9885,293,966SH SOLE1,2,35,293,96600
PULMONX CORPCOM74584810141,9021,164,600SH SOLE1,2,31,164,60000
REGENXBIO INCCOM75901B10777,3581,845,366SH SOLE1,2,31,845,36600
RELMADA THERAPEUTICS INCCOM75955J40240,3121,538,026SH SOLE1,2,31,538,02600
RENOVACOR INC*W EXP 99/99/99975989E114224350,000SH SOLE1,2,3350,00000
RENOVACOR INCCOM75989E10619,2542,187,540SH SOLE1,2,32,187,54000
RESEARCH ALLIANCE CORP IICOM CL A7608731096,274637,000SH SOLE1,2,3637,00000
ROCKET PHARMACEUTICALS INCCOM77313F106469,60115,802,802SH SOLE1,2,315,802,80200
RXSIGHT INCCOM78349D1071,901150,000SH SOLE1,2,3150,00000
SEMA4 HOLDINGS CORPCOM CL A81663L1012,936400,000SH SOLE1,2,3400,00000
SCHOLAR ROCK HLDG CORPCOM80706P1035,336161,612SH SOLE1,2,3161,61200
SIGHT SCIENCES INCCOM82657M10529,1441,283,871SH SOLE1,2,31,283,87100
SINGULAR GENOMICS SYSTEMS INCOM82933R1001,119100,000SH SOLE1,2,3100,00000
SOPHIA GENETICS SAORDINARY SHARESH820271055,259300,000SH SOLE1,2,3300,00000
SPDR S&P 500 ETF TRTR UNIT78462F103374,749873,255SH SOLE1,2,3873,25500
STOKE THERAPEUTICS INCCOM86150R10792,7103,644,248SH SOLE1,2,33,644,24800
SUMMIT HEALTHCRE ACQUISTN COUNIT 06/03/2026G8566R1285,025500,000SH SOLE1,2,3500,00000
TANDEM DIABETES CARE INCCOM NEW875372203138,5681,160,734SH SOLE1,2,31,160,73400
TANGO THERAPEUTICS INCCOM87583X1097,758600,000SH SOLE1,2,3600,00000
TARSUS PHARMACEUTICALS INCCOM87650L10343,3932,013,601SH SOLE1,2,32,013,60100
TELA BIO INCCOM87238110819,0101,391,619SH SOLE1,2,31,391,61900
TENAYA THERAPEUTICS INCCOM87990A10648,5812,458,750SH SOLE1,2,32,458,75000
THERMO FISHER SCIENTIFIC INCCOM883556102237,673416,000SH SOLE1,2,3416,00000
TWIST BIOSCIENCE CORPCOM90184D1001,97618,473SH SOLE1,2,318,47300
UROGEN PHARMA LTDCOMM9608810514,423857,464SH SOLE1,2,3857,46400
VERICEL CORPCOM92346J108220,4574,517,570SH SOLE1,2,34,517,57000
VINCERX PHARMA INCCOM NEW92731L10612,127749,999SH SOLE1,2,3749,99900
ZYMERGEN INCCOM98985X10092270,000SH SOLE1,2,370,00000