The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 64,322 | 596,294 | SH | DFND | 1,2,3 | 596,294 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 812 | 121,019 | SH | DFND | 1,2,3 | 121,019 | 0 | 0 | |
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 1,889 | 242,500 | SH | DFND | 1,2,3 | 242,500 | 0 | 0 | |
AFFIMED N V | COM | N01045108 | 6,907 | 1,117,619 | SH | DFND | 1,2,3 | 1,117,619 | 0 | 0 | |
ALIGOS THERAPEUTICS INC | COM | 01626L105 | 3,865 | 249,197 | SH | DFND | 1,2,3 | 249,197 | 0 | 0 | |
ALLOT LTD | SHS | M0854Q105 | 5,068 | 341,067 | SH | DFND | 341,067 | 0 | 0 | ||
ALTIMMUNE INC | COM NEW | 02155H200 | 12,315 | 1,088,854 | SH | DFND | 1,2,3 | 1,088,854 | 0 | 0 | |
ALTIMMUNE INC | CALL | 02155H200 | 11,310 | 1,000,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 1,000,000 |
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 9,506 | 128,706 | SH | DFND | 1,2,3 | 128,706 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 529 | 161 | SH | DFND | 161 | 0 | 0 | ||
AMICUS THERAPEUTICS INC | COM | 03152W109 | 4,691 | 491,159 | SH | DFND | 1,2,3 | 491,159 | 0 | 0 | |
ANNEXON INC | COM | 03589W102 | 2,301 | 123,637 | SH | DFND | 1,2,3 | 123,637 | 0 | 0 | |
APPLIED MATLS INC | COM | 038222105 | 1,867 | 14,500 | SH | DFND | 14,500 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 2,793 | 9,249 | SH | DFND | 1,2,3 | 9,249 | 0 | 0 | |
ARYA SCIENCES ACQU CORP IV | CL A | G31659108 | 10,060 | 1,000,000 | SH | DFND | 1,2,3 | 1,000,000 | 0 | 0 | |
ARYA SCIENCES ACQUISITN CORP | CLASS A ORD SHS | G31658100 | 1,976 | 200,000 | SH | DFND | 1,2,3 | 200,000 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 77,578 | 1,291,667 | SH | DFND | 1,2,3 | 1,291,667 | 0 | 0 | |
AUDIOCODES LTD | ORD | M15342104 | 10,297 | 316,428 | SH | DFND | 316,428 | 0 | 0 | ||
AUTODESK INC | COM | 052769106 | 7,842 | 27,500 | SH | DFND | 27,500 | 0 | 0 | ||
BCLS ACQUISITION CORP | COM CL A | G0904B105 | 6,879 | 687,900 | SH | DFND | 1,2,3 | 687,900 | 0 | 0 | |
BIOATLA INC | COM | 09077B104 | 6,309 | 214,300 | SH | DFND | 1,2,3 | 214,300 | 0 | 0 | |
BIOGEN INC | CALL | 09062X103 | 14,149 | 50,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 50,000 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 11,518 | 149,017 | SH | DFND | 1,2,3 | 149,017 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | CALL | 110122108 | 29,585 | 500,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 500,000 |
C4 THERAPEUTICS INC | COM STK | 12529R107 | 17,058 | 381,774 | SH | DFND | 1,2,3 | 381,774 | 0 | 0 | |
CAESARSTONE LTD | ORD SHS | M20598104 | 8,000 | 644,146 | SH | DFND | 644,146 | 0 | 0 | ||
CALIX INC | COM | 13100M509 | 5,204 | 105,290 | SH | DFND | 105,290 | 0 | 0 | ||
CARIBOU BIOSCIENCES INC | COM | 142038108 | 4,774 | 200,000 | SH | DFND | 1,2,3 | 200,000 | 0 | 0 | |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 7,037 | 130,330 | SH | DFND | 1,2,3 | 130,330 | 0 | 0 | |
CM LIFE SCIENCES III INC | UNIT 04/30/2028 | 125841205 | 769 | 75,000 | SH | DFND | 1,2,3 | 75,000 | 0 | 0 | |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 11,549 | 548,643 | SH | DFND | 1,2,3 | 548,643 | 0 | 0 | |
CVRX INC | COM | 126638105 | 2,481 | 150,000 | SH | DFND | 1,2,3 | 150,000 | 0 | 0 | |
CYCLACEL PHARMACEUTICALS INC | COM | 23254L603 | 2,679 | 508,322 | SH | DFND | 1,2,3 | 508,322 | 0 | 0 | |
CYTEIR THERAPEUTICS INC | COM | 23284P103 | 2,372 | 135,145 | SH | DFND | 1,2,3 | 135,145 | 0 | 0 | |
DICE THERAPEUTICS INC | COM | 23345J104 | 2,784 | 85,000 | SH | DFND | 1,2,3 | 85,000 | 0 | 0 | |
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 3,820 | 198,880 | SH | DFND | 1,2,3 | 198,880 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 3,655 | 225,083 | SH | DFND | 1,2,3 | 225,083 | 0 | 0 | |
ERASCA INC | COM | 29479A108 | 1,485 | 70,000 | SH | DFND | 1,2,3 | 70,000 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 3,755 | 469,402 | SH | DFND | 1,2,3 | 469,402 | 0 | 0 | |
EUCRATES BIOMEDICAL ACQU COR | SHS | G3141W106 | 3,218 | 329,025 | SH | DFND | 1,2,3 | 329,025 | 0 | 0 | |
FACEBOOK INC | CL A | 30303M102 | 11,675 | 34,400 | SH | DFND | 34,400 | 0 | 0 | ||
FATE THERAPEUTICS INC | COM | 31189P102 | 12,998 | 219,299 | SH | DFND | 1,2,3 | 219,299 | 0 | 0 | |
FRAZIER LIFESCIENCES ACQU CO | CL A SHS | G3710A105 | 1,244 | 126,687 | SH | DFND | 1,2,3 | 126,687 | 0 | 0 | |
GENERAC HLDGS INC | COM | 368736104 | 29,021 | 71,013 | SH | DFND | 71,013 | 0 | 0 | ||
GRAPHITE BIO INC | COM | 38870X104 | 8,707 | 531,269 | SH | DFND | 1,2,3 | 531,269 | 0 | 0 | |
HIPPO HLDGS INC | COMMON STOCK | 433539103 | 2,644 | 564,967 | SH | DFND | 564,967 | 0 | 0 | ||
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 7,510 | 294,619 | SH | DFND | 1,2,3 | 294,619 | 0 | 0 | |
IMMATICS N.V | *W EXP 07/01/202 | N44445117 | 423 | 100,000 | SH | DFND | 1,2,3 | 100,000 | 0 | 0 | |
IMMATICS N.V | SHS | N44445109 | 10,401 | 800,043 | SH | DFND | 1,2,3 | 800,043 | 0 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 3,450 | 389,812 | SH | DFND | 1,2,3 | 389,812 | 0 | 0 | |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 157 | 4,235 | SH | DFND | 1,2,3 | 4,235 | 0 | 0 | |
INHIBRX INC | COM | 45720L107 | 10,329 | 310,077 | SH | DFND | 1,2,3 | 310,077 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 3,172 | 23,647 | SH | DFND | 1,2,3 | 23,647 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 738 | 22,000 | SH | DFND | 1,2,3 | 22,000 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | CALL | 462222100 | 11,739 | 350,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 350,000 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 12,202 | 494,809 | SH | DFND | 1,2,3 | 494,809 | 0 | 0 | |
IRONSOURCE LTD | CL A ORD SHS | M5R75Y101 | 3,990 | 367,070 | SH | DFND | 367,070 | 0 | 0 | ||
ISHARES TR | PUT | 464287655 | 45,938 | 210,000 | SH | Put | DFND | 210,000 | 0 | 0 | |
IVERIC BIO INC | COM | 46583P102 | 7,876 | 485,001 | SH | DFND | 1,2,3 | 485,001 | 0 | 0 | |
JIYA ACQUISITION CORP | COM CL A | 47760M102 | 1,946 | 199,028 | SH | DFND | 1,2,3 | 199,028 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 38,590 | 238,948 | SH | DFND | 1,2,3 | 238,948 | 0 | 0 | |
KORNIT DIGITAL LTD | SHS | M6372Q113 | 10,432 | 72,076 | SH | DFND | 72,076 | 0 | 0 | ||
KURA ONCOLOGY INC | COM | 50127T109 | 14,773 | 788,735 | SH | DFND | 1,2,3 | 788,735 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 21,103 | 359,260 | SH | DFND | 1,2,3 | 359,260 | 0 | 0 | |
LAVA THERAPEUTICS NV | SHS | N51517105 | 1,275 | 215,359 | SH | DFND | 1,2,3 | 215,359 | 0 | 0 | |
LESLIES INC | COM | 527064109 | 3,081 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
LILLY ELI & CO | COM | 532457108 | 80,520 | 348,495 | SH | DFND | 1,2,3 | 348,495 | 0 | 0 | |
LOGICBIO THERAPEUTICS INC | COM | 54142F102 | 110 | 24,042 | SH | DFND | 1,2,3 | 24,042 | 0 | 0 | |
MAGIC SOFTWARE ENTERPRISES L | ORD | 559166103 | 1,154 | 57,704 | SH | DFND | 57,704 | 0 | 0 | ||
MERUS N V | COM | N5749R100 | 6,807 | 309,427 | SH | DFND | 1,2,3 | 309,427 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 19,040 | 67,536 | SH | DFND | 67,536 | 0 | 0 | ||
MOLECULAR PARTNERS AG | ADS | 60853G106 | 1,580 | 80,555 | SH | DFND | 1,2,3 | 80,555 | 0 | 0 | |
MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 2,666 | 119,647 | SH | DFND | 1,2,3 | 119,647 | 0 | 0 | |
NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 | 4,912 | 800,000 | SH | DFND | 1,2,3 | 800,000 | 0 | 0 | |
NICE LTD | SPONSORED ADR | 653656108 | 10,733 | 37,786 | SH | DFND | 37,786 | 0 | 0 | ||
NICE SYS INC | NOTE 1.250% 1/1 | 65366HAB9 | 846 | 250,000 | SH | DFND | 250,000 | 0 | 0 | ||
NIKE INC | CL B | 654106103 | 9,440 | 65,000 | SH | DFND | 65,000 | 0 | 0 | ||
OMEGA ALPHA SPAC | CL A | G6749V107 | 974 | 100,000 | SH | DFND | 1,2,3 | 100,000 | 0 | 0 | |
OMEGA THERAPEUTICS INC | COMMON STOCK | 68217N105 | 9,952 | 527,948 | SH | DFND | 1,2,3 | 527,948 | 0 | 0 | |
ONCORUS INC | COM | 68236R103 | 8,226 | 880,702 | SH | DFND | 1,2,3 | 880,702 | 0 | 0 | |
OTONOMO TECHNOLOGIES LTD | ORDINARY SHARES | M7571L103 | 2,868 | 600,000 | SH | DFND | 600,000 | 0 | 0 | ||
OUTBRAIN INC | COM | 69002R103 | 6,382 | 431,194 | SH | DFND | 431,194 | 0 | 0 | ||
OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 26 | 129,500 | SH | DFND | 1,2,3 | 129,500 | 0 | 0 | |
PALO ALTO NETWORKS INC | COM | 697435105 | 14,849 | 31,000 | SH | DFND | 31,000 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 47,592 | 1,106,528 | SH | DFND | 1,2,3 | 1,106,528 | 0 | 0 | |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 5,678 | 190,525 | SH | DFND | 1,2,3 | 190,525 | 0 | 0 | |
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 5,684 | 739,190 | SH | DFND | 1,2,3 | 739,190 | 0 | 0 | |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 4,614 | 260,379 | SH | DFND | 1,2,3 | 260,379 | 0 | 0 | |
PROTAGONIST THERAPEUTICS INC | CALL | 74366E102 | 4,430 | 250,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 250,000 |
REPARE THERAPEUTICS INC | COM | 760273102 | 2,634 | 100,391 | SH | DFND | 1,2,3 | 100,391 | 0 | 0 | |
RESEARCH ALLIANCE CORP II | COM CL A | 760873109 | 5,910 | 600,000 | SH | DFND | 1,2,3 | 600,000 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 40,660 | 843,400 | SH | DFND | 1,2,3 | 843,400 | 0 | 0 | |
SARISSA CAPITAL ACQUISITN CO | CL A | G7823W102 | 236 | 23,900 | SH | DFND | 1,2,3 | 23,900 | 0 | 0 | |
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 13,261 | 50,000 | SH | DFND | 50,000 | 0 | 0 | ||
SPDR SER TR | PUT | 78464A870 | 50,284 | 400,000 | SH | Put | DFND | 1,2,3 | 400,000 | 0 | 0 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 15,728 | 247,917 | SH | DFND | 1,2,3 | 247,917 | 0 | 0 | |
SUNRUN INC | COM | 86771W105 | 8,316 | 189,000 | SH | DFND | 189,000 | 0 | 0 | ||
SUTRO BIOPHARMA INC | COM | 869367102 | 5,569 | 294,825 | SH | DFND | 1,2,3 | 294,825 | 0 | 0 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 14,344 | 750,603 | SH | DFND | 1,2,3 | 750,603 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 8,112 | 832,878 | SH | DFND | 832,878 | 0 | 0 | ||
TEVA PHARMACEUTICAL INDS LTD | CALL | 881624209 | 10,227 | 1,050,000 | SH | Call | DFND | 0 | 0 | 1,050,000 | |
TURMERIC ACQUISITION CORP | CL A | G9127T108 | 2,148 | 219,440 | SH | DFND | 1,2,3 | 219,440 | 0 | 0 | |
TWILIO INC | CL A | 90138F102 | 11,326 | 35,500 | SH | DFND | 35,500 | 0 | 0 | ||
UNIQURE NV | SHS | N90064101 | 5,506 | 172,000 | SH | DFND | 1,2,3 | 172,000 | 0 | 0 | |
UNIQURE NV | CALL | N90064101 | 3,201 | 100,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 100,000 |
UPWORK INC | COM | 91688F104 | 450 | 10,000 | SH | DFND | 10,000 | 0 | 0 | ||
VERINT SYS INC | COM | 92343X100 | 6,719 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 4,391 | 801,256 | SH | DFND | 1,2,3 | 801,256 | 0 | 0 | |
VINCERX PHARMA INC | COM NEW | 92731L106 | 10,584 | 654,572 | SH | DFND | 1,2,3 | 654,572 | 0 | 0 | |
VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 10,480 | 3,824,938 | SH | DFND | 1,2,3 | 3,824,938 | 0 | 0 | |
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 11,814 | 688,475 | SH | DFND | 1,2,3 | 688,475 | 0 | 0 | |
WIX COM LTD | NOTE 8/1 | 92940WAD1 | 10,722 | 11,100,000 | SH | DFND | 11,100,000 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 5,707 | 373,510 | SH | DFND | 1,2,3 | 373,510 | 0 | 0 | |
YUMANITY THERAPEUTICS INC | COM | 98872L102 | 783 | 75,836 | SH | DFND | 1,2,3 | 75,836 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 15,385 | 145,982 | SH | DFND | 1,2,3 | 145,982 | 0 | 0 | |
ZENDESK INC | COM | 98936J101 | 6,275 | 53,910 | SH | DFND | 53,910 | 0 | 0 |