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Sphera Funds Management

Filed: 15 Nov 21, 3:41pm

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABBVIE INCCOM00287Y10964,322596,294SH DFND1,2,3596,29400
AC IMMUNE SASHSH00263105812121,019SH DFND1,2,3121,01900
ACHILLES THERAPEUTICS PLCSPONSORED ADS00449L1021,889242,500SH DFND1,2,3242,50000
AFFIMED N VCOMN010451086,9071,117,619SH DFND1,2,31,117,61900
ALIGOS THERAPEUTICS INCCOM01626L1053,865249,197SH DFND1,2,3249,19700
ALLOT LTDSHSM0854Q1055,068341,067SH DFND 341,06700
ALTIMMUNE INCCOM NEW02155H20012,3151,088,854SH DFND1,2,31,088,85400
ALTIMMUNE INCCALL02155H20011,3101,000,000SHCallDFND1,2,3001,000,000
ALX ONCOLOGY HLDGS INCCOM00166B1059,506128,706SH DFND1,2,3128,70600
AMAZON COM INCCOM023135106529161SH DFND 16100
AMICUS THERAPEUTICS INCCOM03152W1094,691491,159SH DFND1,2,3491,15900
ANNEXON INCCOM03589W1022,301123,637SH DFND1,2,3123,63700
APPLIED MATLS INCCOM0382221051,86714,500SH DFND 14,50000
ARGENX SESPONSORED ADR04016X1012,7939,249SH DFND1,2,39,24900
ARYA SCIENCES ACQU CORP IVCL AG3165910810,0601,000,000SH DFND1,2,31,000,00000
ARYA SCIENCES ACQUISITN CORPCLASS A ORD SHSG316581001,976200,000SH DFND1,2,3200,00000
ASTRAZENECA PLCSPONSORED ADR04635310877,5781,291,667SH DFND1,2,31,291,66700
AUDIOCODES LTDORDM1534210410,297316,428SH DFND 316,42800
AUTODESK INCCOM0527691067,84227,500SH DFND 27,50000
BCLS ACQUISITION CORPCOM CL AG0904B1056,879687,900SH DFND1,2,3687,90000
BIOATLA INCCOM09077B1046,309214,300SH DFND1,2,3214,30000
BIOGEN INCCALL09062X10314,14950,000SHCallDFND1,2,30050,000
BIOMARIN PHARMACEUTICAL INCCOM09061G10111,518149,017SH DFND1,2,3149,01700
BRISTOL-MYERS SQUIBB COCALL11012210829,585500,000SHCallDFND1,2,300500,000
C4 THERAPEUTICS INCCOM STK12529R10717,058381,774SH DFND1,2,3381,77400
CAESARSTONE LTDORD SHSM205981048,000644,146SH DFND 644,14600
CALIX INCCOM13100M5095,204105,290SH DFND 105,29000
CARIBOU BIOSCIENCES INCCOM1420381084,774200,000SH DFND1,2,3200,00000
CELLDEX THERAPEUTICS INC NEWCOM NEW15117B2027,037130,330SH DFND1,2,3130,33000
CM LIFE SCIENCES III INCUNIT 04/30/202812584120576975,000SH DFND1,2,375,00000
CRINETICS PHARMACEUTICALS INCOM22663K10711,549548,643SH DFND1,2,3548,64300
CVRX INCCOM1266381052,481150,000SH DFND1,2,3150,00000
CYCLACEL PHARMACEUTICALS INCCOM23254L6032,679508,322SH DFND1,2,3508,32200
CYTEIR THERAPEUTICS INCCOM23284P1032,372135,145SH DFND1,2,3135,14500
DICE THERAPEUTICS INCCOM23345J1042,78485,000SH DFND1,2,385,00000
DYNAVAX TECHNOLOGIES CORPCOM NEW2681582013,820198,880SH DFND1,2,3198,88000
DYNE THERAPEUTICS INCCOM26818M1083,655225,083SH DFND1,2,3225,08300
ERASCA INCCOM29479A1081,48570,000SH DFND1,2,370,00000
ESSA PHARMA INCCOM NEW29668H7083,755469,402SH DFND1,2,3469,40200
EUCRATES BIOMEDICAL ACQU CORSHSG3141W1063,218329,025SH DFND1,2,3329,02500
FACEBOOK INCCL A30303M10211,67534,400SH DFND 34,40000
FATE THERAPEUTICS INCCOM31189P10212,998219,299SH DFND1,2,3219,29900
FRAZIER LIFESCIENCES ACQU COCL A SHSG3710A1051,244126,687SH DFND1,2,3126,68700
GENERAC HLDGS INCCOM36873610429,02171,013SH DFND 71,01300
GRAPHITE BIO INCCOM38870X1048,707531,269SH DFND1,2,3531,26900
HIPPO HLDGS INCCOMMON STOCK4335391032,644564,967SH DFND 564,96700
IDEAYA BIOSCIENCES INCCOM45166A1027,510294,619SH DFND1,2,3294,61900
IMMATICS N.V*W EXP 07/01/202N44445117423100,000SH DFND1,2,3100,00000
IMMATICS N.VSHSN4444510910,401800,043SH DFND1,2,3800,04300
IMMUNIC INCCOM4525EP1013,450389,812SH DFND1,2,3389,81200
IMMUNOCORE HLDGS PLCADS45258D1051574,235SH DFND1,2,34,23500
INHIBRX INCCOM45720L10710,329310,077SH DFND1,2,3310,07700
INTELLIA THERAPEUTICS INCCOM45826J1053,17223,647SH DFND1,2,323,64700
IONIS PHARMACEUTICALS INCCOM46222210073822,000SH DFND1,2,322,00000
IONIS PHARMACEUTICALS INCCALL46222210011,739350,000SHCallDFND1,2,300350,000
IOVANCE BIOTHERAPEUTICS INCCOM46226010012,202494,809SH DFND1,2,3494,80900
IRONSOURCE LTDCL A ORD SHSM5R75Y1013,990367,070SH DFND 367,07000
ISHARES TRPUT46428765545,938210,000SHPutDFND 210,00000
IVERIC BIO INCCOM46583P1027,876485,001SH DFND1,2,3485,00100
JIYA ACQUISITION CORPCOM CL A47760M1021,946199,028SH DFND1,2,3199,02800
JOHNSON & JOHNSONCOM47816010438,590238,948SH DFND1,2,3238,94800
KORNIT DIGITAL LTDSHSM6372Q11310,43272,076SH DFND 72,07600
KURA ONCOLOGY INCCOM50127T10914,773788,735SH DFND1,2,3788,73500
KYMERA THERAPEUTICS INCCOM50157510421,103359,260SH DFND1,2,3359,26000
LAVA THERAPEUTICS NVSHSN515171051,275215,359SH DFND1,2,3215,35900
LESLIES INCCOM5270641093,081150,000SH DFND 150,00000
LILLY ELI & COCOM53245710880,520348,495SH DFND1,2,3348,49500
LOGICBIO THERAPEUTICS INCCOM54142F10211024,042SH DFND1,2,324,04200
MAGIC SOFTWARE ENTERPRISES LORD5591661031,15457,704SH DFND 57,70400
MERUS N VCOMN5749R1006,807309,427SH DFND1,2,3309,42700
MICROSOFT CORPCOM59491810419,04067,536SH DFND 67,53600
MOLECULAR PARTNERS AGADS60853G1061,58080,555SH DFND1,2,380,55500
MONTE ROSA THERAPEUTICS INCCOM61225M1022,666119,647SH DFND1,2,3119,64700
NAUTILUS BIOTECHNOLOGY INCCOM63909J1084,912800,000SH DFND1,2,3800,00000
NICE LTDSPONSORED ADR65365610810,73337,786SH DFND 37,78600
NICE SYS INCNOTE 1.250% 1/165366HAB9846250,000SH DFND 250,00000
NIKE INCCL B6541061039,44065,000SH DFND 65,00000
OMEGA ALPHA SPACCL AG6749V107974100,000SH DFND1,2,3100,00000
OMEGA THERAPEUTICS INCCOMMON STOCK68217N1059,952527,948SH DFND1,2,3527,94800
ONCORUS INCCOM68236R1038,226880,702SH DFND1,2,3880,70200
OTONOMO TECHNOLOGIES LTDORDINARY SHARESM7571L1032,868600,000SH DFND 600,00000
OUTBRAIN INCCOM69002R1036,382431,194SH DFND 431,19400
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11526129,500SH DFND1,2,3129,50000
PALO ALTO NETWORKS INCCOM69743510514,84931,000SH DFND 31,00000
PFIZER INCCOM71708110347,5921,106,528SH DFND1,2,31,106,52800
PMV PHARMACEUTICALS INCCOM69353Y1035,678190,525SH DFND1,2,3190,52500
POINT BIOPHARMA GLOBAL INCCOM7305411095,684739,190SH DFND1,2,3739,19000
PROTAGONIST THERAPEUTICS INCCOM74366E1024,614260,379SH DFND1,2,3260,37900
PROTAGONIST THERAPEUTICS INCCALL74366E1024,430250,000SHCallDFND1,2,300250,000
REPARE THERAPEUTICS INCCOM7602731022,634100,391SH DFND1,2,3100,39100
RESEARCH ALLIANCE CORP IICOM CL A7608731095,910600,000SH DFND1,2,3600,00000
SANOFISPONSORED ADR80105N10540,660843,400SH DFND1,2,3843,40000
SARISSA CAPITAL ACQUISITN COCL AG7823W10223623,900SH DFND1,2,323,90000
SOLAREDGE TECHNOLOGIES INCCOM83417M10413,26150,000SH DFND 50,00000
SPDR SER TRPUT78464A87050,284400,000SHPutDFND1,2,3400,00000
SPRINGWORKS THERAPEUTICS INCCOM85205L10715,728247,917SH DFND1,2,3247,91700
SUNRUN INCCOM86771W1058,316189,000SH DFND 189,00000
SUTRO BIOPHARMA INCCOM8693671025,569294,825SH DFND1,2,3294,82500
SYNDAX PHARMACEUTICALS INCCOM87164F10514,344750,603SH DFND1,2,3750,60300
TEVA PHARMACEUTICAL INDS LTDSPONSORED ADS8816242098,112832,878SH DFND 832,87800
TEVA PHARMACEUTICAL INDS LTDCALL88162420910,2271,050,000SHCallDFND 001,050,000
TURMERIC ACQUISITION CORPCL AG9127T1082,148219,440SH DFND1,2,3219,44000
TWILIO INCCL A90138F10211,32635,500SH DFND 35,50000
UNIQURE NVSHSN900641015,506172,000SH DFND1,2,3172,00000
UNIQURE NVCALLN900641013,201100,000SHCallDFND1,2,300100,000
UPWORK INCCOM91688F10445010,000SH DFND 10,00000
VERINT SYS INCCOM92343X1006,719150,000SH DFND 150,00000
VERONA PHARMA PLCSPONSORED ADS9250501064,391801,256SH DFND1,2,3801,25600
VINCERX PHARMA INCCOM NEW92731L10610,584654,572SH DFND1,2,3654,57200
VISTAGEN THERAPEUTICS INCCOM NEW92840H20210,4803,824,938SH DFND1,2,33,824,93800
WEREWOLF THERAPEUTICS INCCOM95075A10711,814688,475SH DFND1,2,3688,47500
WIX COM LTDNOTE 8/192940WAD110,72211,100,000SH DFND 11,100,00000
XENON PHARMACEUTICALS INCCOM98420N1055,707373,510SH DFND1,2,3373,51000
YUMANITY THERAPEUTICS INCCOM98872L10278375,836SH DFND1,2,375,83600
ZAI LAB LTDADR98887Q10415,385145,982SH DFND1,2,3145,98200
ZENDESK INCCOM98936J1016,27553,910SH DFND 53,91000