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LPTX Leap Therapeutics

Document and Entity Information

Document and Entity Information - shares9 Months Ended
Sep. 30, 2020Nov. 10, 2020
Document and Entity Information
Document Type10-Q
Document Period End DateSep. 30,
2020
Entity Registrant NameLEAP THERAPEUTICS, INC.
Title of 12(b) SecurityCommon Stock, par value $0.001 per share
Trading SymbolLPTX
Security Exchange NameNASDAQ
Entity Current Reporting StatusYes
Entity Interactive Data CurrentYes
Entity Filer CategoryNon-accelerated Filer
Entity Small Businesstrue
Entity Emerging Growth Companytrue
Entity Ex Transition Periodfalse
Entity Shell Companyfalse
Entity Common Stock, Shares Outstanding59,657,742
Entity Central Index Key0001509745
Current Fiscal Year End Date--12-31
Document Fiscal Year Focus2020
Document Fiscal Period FocusQ3
Amendment Flagfalse

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in ThousandsSep. 30, 2020Dec. 31, 2019
Current assets:
Cash and cash equivalents $ 57,975 $ 3,891
Research and development incentive receivable209 185
Prepaid expenses and other current assets217 165
Total current assets58,401 4,241
Property and equipment, net73 124
Right of use assets, net620 1,026
Deferred tax assets130 127
Deferred costs379 831
Deposits941 1,099
Total assets60,544 7,448
Current liabilities:
Accounts payable2,547 4,571
Accrued expenses2,270 3,441
Deferred revenue - current portion1,500
Lease liability - current portion398 474
Total current liabilities6,715 8,486
Non current liabilities:
Restricted stock liability66 159
Deferred revenue, net of current portion375
Lease liability, net of current portion250 552
Total liabilities7,406 9,197
Stockholders' equity (deficiency):
Common stock, $0.001 par value; 240,000,000 and 100,000,000 shares authorized as of September 30, 2020 and December 31, 2019, respectively; 59,657,742 and 24,194,877 shares issued and outstanding as of September 30, 2020 and December 31, 2019, respectively60 24
Additional paid-in capital269,440 193,319
Accumulated other comprehensive income (loss)(87)76
Accumulated deficit(216,275)(195,168)
Total stockholders' equity (deficiency)53,138 (1,749)
Total liabilities and stockholders' equity (deficiency) $ 60,544 $ 7,448

CONDENSED CONSOLIDATED BALANC_2

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / sharesSep. 30, 2020Dec. 31, 2019
CONDENSED CONSOLIDATED BALANCE SHEETS
Common stock, par value (in dollars per share) $ 0.001 $ 0.001
Common stock, authorized shares240,000,000 100,000,000
Common stock, issued shares59,657,742 24,194,877
Common stock, outstanding shares59,657,742 24,194,877

CONDENSED CONSOLIDATED STATEMEN

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
License revenue $ 375 $ 1,125
Operating expenses:
Research and development5,369 $ 5,772 15,322 $ 18,698
General and administrative2,514 2,151 7,188 6,481
Total operating expenses7,883 7,923 22,510 25,179
Loss from operations(7,508)(7,923)(21,385)(25,179)
Interest income3 80 91 281
Interest expense(17)(5)(42)(21)
Australian research and development incentives228 (7)343 129
Foreign currency gains (loss)237 (80)189 (114)
Loss before income taxes(7,057)(7,935)(20,804)(24,904)
Net loss(7,057)(7,935)(20,804)(24,904)
Dividend attributable to down round feature of warrants(303)(359)
Dividend attributable to Series A & B convertible preferred stock(372)
Series A & B convertible preferred stock - beneficial conversion feature(9,399)
Net loss attributable to common stockholders $ (7,057) $ (7,935) $ (30,878) $ (25,263)
Net loss per share
Basic (in dollars per share) $ (0.09) $ (0.33) $ (0.58) $ (1.15)
Diluted (in dollars per share) $ (0.09) $ (0.33) $ (0.58) $ (1.15)
Weighted average common shares outstanding
Basic (in shares)76,321,644 23,923,196 53,548,902 22,039,386
Diluted (in shares)76,321,644 23,923,196 53,548,902 22,039,386

CONDENSED CONSOLIDATED STATEM_2

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
Net loss $ (7,057) $ (7,935) $ (20,804) $ (24,904)
Other comprehensive income (loss):
Foreign currency translation adjustments(208)5 (163)25
Comprehensive loss $ (7,265) $ (7,930) $ (20,967) $ (24,879)

CONDENSED CONSOLIDATED STATEM_3

CONDENSED CONSOLIDATED STATEMENTS OF COVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY - USD ($)Series A Convertible Preferred StockSeries B Convertible Preferred Stock2020 Public offeringCommon Stock2020 Public offeringAdditional Paid- In Capital2020 Public offeringLincoln Park Capital Commitment Purchase Agreement Offering MemberCommon Stock2019 Public OfferingCommon Stock2019 Public OfferingAdditional Paid- In Capital2019 Public OfferingLincoln Park Capital Registered Offering Purchase Agreement Offering MemberCommon StockLincoln Park Capital Registered Offering Purchase Agreement Offering MemberAdditional Paid- In CapitalLincoln Park Capital Registered Offering Purchase Agreement Offering MemberCommon StockAdditional Paid- In CapitalAccumulated Other Comprehensive Income (loss)Accumulated DeficitTotal
Balance at the beginning of the period (in shares) at Dec. 31, 201814,703,159
Increase (Decrease) in Shares Outstanding
Issuance of common stock through ATM sales (in shares)1,033,147
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)330,000 7,557,142 571,429
Balance at the end of the period (in shares) at Sep. 30, 201924,194,877
Balance at the beginning of the period at Dec. 31, 2018 $ 15,000 $ 162,393,000 $ 302,000 $ (153,535,000) $ 9,175,000
Increase (Decrease) in Stockholders' Equity
Issuance of common stock through ATM sales1,000 1,922,000 1,923,000
To record ATM issuance costs in additional paid-in-capital(13,000)(13,000)
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts $ 7,000 $ 12,115,000 $ 12,122,000 $ 1,000 $ 989,000 $ 990,000
Reclassification of 2017 warrants from liability to equity11,822,000 (8,374,000)3,448,000
Dividend attributable to down round feature of 2017 warrants $ 359,000 359,000 (359,000)359,000
Foreign currency translation adjustment25,000 25,000
Stock-based compensation2,796,000 2,796,000
Net loss(24,904,000)(24,904,000)
Balance at the end of the period at Sep. 30, 2019 $ 24,000 192,383,000 327,000 (187,172,000)5,562,000
Balance at the beginning of the period (in shares) at Dec. 31, 201814,703,159
Balance at the end of the period (in shares) at Dec. 31, 20190 0 24,194,877
Balance at the beginning of the period at Dec. 31, 2018 $ 15,000 162,393,000 302,000 (153,535,000)9,175,000
Balance at the end of the period at Dec. 31, 2019 $ 0 $ 0 $ 24,000 193,319,000 76,000 (195,168,000)(1,749,000)
Balance at the beginning of the period (in shares) at Jun. 30, 201922,949,064
Increase (Decrease) in Shares Outstanding
Issuance of common stock through ATM sales (in shares)344,384
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)571,429
Balance at the end of the period (in shares) at Sep. 30, 201924,194,877
Balance at the beginning of the period at Jun. 30, 2019 $ 23,000 189,831,000 322,000 (179,237,000)10,939,000
Increase (Decrease) in Stockholders' Equity
Issuance of common stock through ATM sales617,000 617,000
To record ATM issuance costs in additional paid-in-capital(4,000)(4,000)
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts $ 330,000 $ 1,000 $ 989,000 $ 990,000
Foreign currency translation adjustment5,000 5,000
Stock-based compensation950,000 950,000
Net loss(7,935,000)(7,935,000)
Balance at the end of the period at Sep. 30, 2019 $ 24,000 192,383,000 327,000 (187,172,000) $ 5,562,000
Balance at the beginning of the period (in shares) at Dec. 31, 20190 0 24,194,877
Increase (Decrease) in Shares Outstanding
Conversion of Series A Convertible Preferred Stock to prefunded warrants (in shares)(1,421,801)
Conversion of Series B Convertible Preferred Stock to common stock (in shares)(1,137,442)11,374,420
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)1,421,801 1,137,442 23,625,000
Issuance of common stock upon exercise of warrant (in shares)273,954
Issuance of common stock upon exercise of stock options (in shares)32,778 32,778
Balance at the end of the period (in shares) at Sep. 30, 20200 0 59,657,742
Balance at the beginning of the period at Dec. 31, 2019 $ 0 $ 0 $ 24,000 193,319,000 76,000 (195,168,000) $ (1,749,000)
Increase (Decrease) in Stockholders' Equity
Issuance of common stock upon exercise of warrants348,000 348,000
Series A & B Convertible Preferred Stock discount - beneficial conversion feature5,226,000 4,173,000 (9,399,000)(9,399,000)
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts14,062,000 11,260,000 $ 24,000 $ 48,252,000 $ 48,276,000
Series A & B Convertible Preferred Stock accrued dividends(207,000)(165,000)(372,000)(372,000)
Conversion of Series A & B Convertible Preferred Stock dividends to prefunded warrants and common stock(207,000)(165,000) $ 1,000 371,000 372,000
Conversion of Series A & B Convertible Preferred Stock dividends to prefunded warrants and common stock156,713
Conversion of Series A Convertible Preferred Stock to prefunded warrants8,836,000 (8,836,000)(8,836,000)
Conversion of Series B Convertible Preferred Stock to common stock(7,087,000) $ 11,000 7,076,000 7,087,000
Dividend attributable to down round feature of 2017 warrants303,000 (303,000)303,000
Issuance of common stock upon exercise of stock options51,000 51,000
Foreign currency translation adjustment(163,000)(163,000)
Stock-based compensation1,857,000 1,857,000
Net loss(20,804,000)(20,804,000)
Balance at the end of the period at Sep. 30, 2020 $ 0 $ 0 $ 60,000 269,440,000 (87,000)(216,275,000)53,138,000
Balance at the beginning of the period (in shares) at Jun. 30, 20200 0 59,657,742
Balance at the end of the period (in shares) at Sep. 30, 20200 0 59,657,742
Balance at the beginning of the period at Jun. 30, 2020 $ 0 $ 0 $ 60,000 268,770,000 121,000 (209,218,000)59,733,000
Increase (Decrease) in Stockholders' Equity
Foreign currency translation adjustment(208,000)(208,000)
Stock-based compensation670,000 670,000
Net loss(7,057,000)(7,057,000)
Balance at the end of the period at Sep. 30, 2020 $ 0 $ 0 $ 60,000 $ 269,440,000 $ (87,000) $ (216,275,000) $ 53,138,000

CONDENSED CONSOLIDATED STATEM_4

CONDENSED CONSOLIDATED STATEMENTS OF COVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (Parenthetical) - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019
2019 Public Offering
CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)
Issuance of common stock, issuance costs $ 1,102
2020 Public offering
CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)
Issuance of common stock, issuance costs $ 3,472
Lincoln Park Capital Registered Offering Purchase Agreement Offering Member
CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)
Issuance of common stock, issuance costs $ 10 $ 10

CONDENSED CONSOLIDATED STATEM_5

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands9 Months Ended
Sep. 30, 2020Sep. 30, 2019
Cash flows from operating activities:
Net loss $ (20,804) $ (24,904)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense26 37
Amortization of contract asset101
Amortization on right-of-use asset406 541
Stock-based compensation expense1,857 2,796
Foreign currency (gain) loss(189)114
Change in fair value of restricted stock liability(94)159
Changes in operating assets and liabilities:
Prepaid expenses and other assets727 280
Research and development incentive receivable(20)(128)
Contract acquisition costs(270)
Accounts payable and accrued expenses(3,206)717
Deferred revenue1,875
Lease liability(378)(506)
Net cash used in operating activities(19,969)(21,008)
Cash flows from investing activities:
Proceeds from the sale of property and equipment25
Purchases of property and equipment(100)
Net cash provided by (used) in investing activities25 (100)
Cash flows from financing activities:
Proceeds from issuance of common stock - June 2020 Public Offering48,518
Proceeds from issuance of common stock12,331
Proceeds from issuance of common stock from ATM sales1,923
Proceeds from issuance of common stock in connection with July 2019 Lincoln Park Capital Registered Offering Purchase Agreement, net of issuance costs999
Proceeds from the exercise of common stock warrants348
Proceeds from the exercise of stock options51
Payment of deferred offering costs(1,906)(417)
Net cash provided by financing activities73,997 14,836
Effect of exchange rate changes on cash and cash equivalents31 46
Net increase (decrease) in cash and cash equivalents54,084 (6,226)
Cash and cash equivalents at beginning of period3,891 16,284
Cash and cash equivalents at end of period57,975 10,058
Supplemental disclosure of non-cash financing activities:
Reclassification of 2017 Warrants from liability to equity3,448
Dividend attributable to down round feature of warrants303 359
Offering costs included in accounts payable and accrued expenses - February 2019 Public Offering20
Right-of-use asset recorded upon adoption of ASU 2016-021,720
Lease liability recorded upon adoption of ASU 2016-021,720
Prepaid rent reclassified upon adoption of ASU 2016-02 $ 35
Conversion of Series A convertible preferred stock to prefunded warrants(8,836)
Conversion of Series B convertible preferred stock to common stock(7,087)
Series A & B Convertible Preferred Stock discount - beneficial conversion feature(9,399)
Series A Convertible Preferred Stock
Cash flows from financing activities:
Proceeds from the issuance of Series convertible preferred stock14,986
Supplemental disclosure of non-cash financing activities:
Conversion of Series A convertible preferred stock to prefunded warrants8,836
Series A & B Convertible Preferred Stock discount - beneficial conversion feature5,226
Series B Convertible Preferred Stock
Cash flows from financing activities:
Proceeds from the issuance of Series convertible preferred stock12,000
Supplemental disclosure of non-cash financing activities:
Conversion of Series B convertible preferred stock to common stock7,087
Series A & B Convertible Preferred Stock discount - beneficial conversion feature $ 4,173

Nature of Business, Basis of Pr

Nature of Business, Basis of Presentation and Liquidity9 Months Ended
Sep. 30, 2020
Nature of Business, Basis of Presentation and Liquidity
Nature of Business, Basis of Presentation and Liquidity1. Nature of Business, Basis of Presentation and Liquidity
Nature of Business
Leap Therapeutics, Inc. was incorporated in the state of Delaware on January 3, 2011. During 2015, HealthCare Pharmaceuticals Pty Ltd. (“HCP Australia”) was formed and is a wholly owned subsidiary of the Company.
The Company is a biopharmaceutical company acquiring and developing novel therapeutics at the leading edge of cancer biology. The Company’s approach is designed to target compelling tumor-promoting and immuno-oncology pathways to generate durable clinical benefit and enhanced outcomes for patients. The Company’s programs are monoclonal antibodies that target key cellular pathways that enable cancer to grow and spread and specific mechanisms that activate the body’s immune system to identify and attack cancer.
Basis of Presentation
The accompanying condensed consolidated financial statements as of September 30, 2020 and for the three and nine months ended September 30, 2020 and 2019 have been prepared by the Company, pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) have been condensed or omitted pursuant to such rules and regulations. However, the Company believes that the disclosures are adequate to make the information presented not misleading. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the year ended December 31, 2019 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 16, 2020.
The condensed consolidated financial statements have been prepared on the same basis as the audited consolidated financial statements. In the opinion of management, the accompanying condensed consolidated financial statements contain all adjustments which are necessary for the fair presentation of the Company’s financial position as of September 30, 2020, statements of operations and statements of comprehensive loss for the three and nine months ended September 30, 2020 and 2019 and statements of cash flows for the nine months ended September 30, 2020 and 2019. Such adjustments are of a normal and recurring nature. The results of operations for the three and nine months ended September 30, 2020 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2020.
Liquidity
Since inception, the Company has been engaged in organizational activities, including raising capital, and research and development activities. The Company does not yet have a product that has been approved by the Food and Drug Administration (the “FDA”), has not generated any product sales revenues and has not yet achieved profitable operations, nor has it ever generated positive cash flows from operations. There is no assurance that profitable operations, if achieved, could be sustained on a continuing basis. Further, the Company’s future operations are dependent on the success of the Company’s efforts to raise additional capital, its research and commercialization efforts, regulatory approval, and, ultimately, the market acceptance of the Company’s products.
In accordance with Accounting Standards Codification (“ASC”) 205‑40, Going Concern, the Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that the condensed consolidated financial statements are issued. As of September 30, 2020, the Company had cash and cash equivalents of $57,975. Additionally, the Company had an accumulated deficit of $216,275 at September 30, 2020, and during the nine months ended September 30, 2020, the Company incurred a net loss of $20,804. The Company expects to continue to generate operating losses for the foreseeable future. The Company believes that its cash and cash equivalents of $57,975 as of September 30, 2020, will be sufficient to fund its operating expenses for at least the next 12 months from issuance of these financial statements.

Summary of Significant Accounti

Summary of Significant Accounting Policies9 Months Ended
Sep. 30, 2020
Summary of Significant Accounting Policies
Summary of Significant Accounting Policies2. Summary of Significant Accounting Policies
Principles of Consolidation
The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions are eliminated upon consolidation.
Use of Estimates
The presentation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
Research and development incentive income and receivable
The Company recognizes other income from Australian research and development incentives when there is reasonable assurance that the income will be received, the relevant expenditure has been incurred, and the consideration can be reliably measured. The research and development incentive is one of the key elements of the Australian Government’s support for Australia’s innovation system and is supported by legislative law primarily in the form of the Australian Income Tax Assessment Act 1997, as long as eligibility criteria are met.
Management has assessed the Company’s research and development activities and expenditures to determine which activities and expenditures are likely to be eligible under the research and development incentive regime described above. At each period end, management estimates the refundable tax offset available to the Company based on available information at the time. This estimate is also reviewed by external tax advisors on an annual basis.
Under the program, a percentage of eligible research and development expenses incurred by the Company through its subsidiary in Australia are reimbursed. The percentage was 43.5% for the year ended December 31, 2019 and for the three and nine months ended September 30, 2020.
The research and development incentive receivable represents an amount due in connection with the above program. The Company has recorded a research and development incentive receivable of $209 and $185 as of September 30, 2020 and December 31, 2019, respectively, in the condensed consolidated balance sheets and other income from Australian research and development incentives of $228 for the three months ended September 30, 2020. During the three months ended September 30, 2019, the Australian research and development incentives recognized were offset by an adjustment to the prior year estimated Australian research and development incentives, resulting in a net expense for the period. During the three months ended September 30, 2020, the Company recorded an adjustment to increase Australian research and development incentive income by approximately $150 as the cash received from the Australian Government during the three months ended September 30, 2020 for 2019 eligible expenditures was higher than the prior year estimated Australian research and development incentives. During the nine months ended September 30, 2020 and 2019, the Company recorded $343 and $129, respectively, of other income from Australian research and development incentives.
The following table shows the change in the research and development incentive receivable from December 31, 2018 to September 30, 2020 (in thousands):
Balance at December 31, 2018
$
836
Australian research and development incentive income, net
132
Cash received for 2018 eligible expenses
(757)
Foreign currency translation
(26)
Balance at December 31, 2019
185
Australian research and development incentive income, net
343
Cash received for 2019 eligible expenses
(331)
Foreign currency translation
12
Balance at September 30, 2020
$
209
Foreign Currency Translation
The financial statements of the Company’s Australian subsidiary are measured using the local currency as the functional currency. Assets and liabilities of this subsidiary are translated into U.S. dollars at an exchange rate as of the consolidated balance sheet date. Equity is translated at historical exchange rates. Revenues and expenses are translated into U.S. dollars at average rates of exchange in effect during the period. The resulting cumulative translation adjustments have been recorded as a separate component of stockholders’ equity. Realized foreign currency transaction gains and losses are included in the results of operations.
Deferred Costs
The Company capitalizes certain legal, professional, accounting and other third-party fees that are directly associated with in-process equity financings as deferred costs until such financings are consummated. After consummation of the equity financing, these costs are recorded in stockholders’ equity (deficiency) as a reduction of additional paid-in capital generated as a result of the offering.
The Company also capitalizes certain contract acquisition costs. During the nine months ended September 30, 2020, the Company incurred contract acquisition costs which were capitalized under ASC 340-40 as incremental costs of obtaining the contract with BeiGene. This cost is amortized on a straight-line basis over the performance period of the research and development services.
As of September 30, 2020 and December 31, 2019 there was $379 and $831, respectively, of deferred costs.
Deposits
As of September 30, 2020 and December 31, 2019, $941 and $1,099, respectively, of deposits made by the Company with certain service providers that are to be applied to future payments due under the service agreements or returned to the Company if not utilized, were recorded in the condensed consolidated balance sheets.
Warrants
On January 1, 2019, the Company adopted ASU No. 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480), and Derivatives and Hedging (Topic 815) (“ASU 2017-11”), which changes the classification analysis of certain equity-linked financial instruments (or embedded features) with down round features. The amendments require entities that present earnings per share (“EPS”) in accordance with Topic 260 to recognize the effect of the down round feature when triggered with the effect treated as a dividend and as a reduction of income available to common stockholders in basic EPS.
The Company concluded that the common stock warrants (the “2017 Warrants”) issued in connection with the private placement of common stock completed in November 2017 (the “November 2017 Private Placement”), qualify for equity classification under ASU 2017-11. The adoption guidance of ASU 2017-11 provides for a modified retrospective adoption. The Company applied the guidance retrospectively to the 2017 Warrants by means of a cumulative-effect adjustment to its statement of financial position as of the beginning of the interim and annual period beginning January 1, 2019. The Company performed a final remeasurement of the warrant liability as of January 1, 2019 and reclassified $3,448 from warrant liability to equity.
The Company will recognize on a prospective basis the value of the effect of the down round feature in the 2017 Warrants when it is triggered (i.e., when the exercise price is adjusted downward). This value is measured as the difference between (1) the financial instrument’s fair value (without the down round feature) using the pre-trigger exercise price and (2) the financial instrument’s fair value (with the down round feature) using the reduced exercise price. The value of the effect of the down round feature will be treated as a dividend and a reduction to income available to common stockholders in the basic EPS calculation. In connection with the public offering, completed in February 2019 (the “2019 Public Offering”), when the 2017 Warrants were repriced from $6.085 to $1.75 as a result of a down round, the Company recorded a dividend of $359 during the nine months ended September 30, 2019. In connection with the private placement of common stock completed in January 2020 (the “January 2020 Private Placement”), when the 2017 Warrants were repriced from $1.75 to $1.055 as a result of a down round, the Company recorded a dividend of $303 during the nine months ended September 30, 2020.
Fair Value of Financial Instruments
Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable:
·
Level 1—Quoted prices in active markets for identical assets or liabilities.
·
Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data.
·
Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.
During the periods presented, the Company has not changed the manner in which it values assets and liabilities that are measured at fair value using Level 3 inputs. There were no transfers within the hierarchy during the three and nine months ended September 30, 2020 or the year ended December 31, 2019.
A summary of the assets and liabilities carried at fair value in accordance with the hierarchy defined above is as follows (in thousands):
Total
Level 1
Level 2
Level 3
September 30, 2020
Assets:
Cash equivalents
$
57,975
$
57,975
$

$

Total assets
$
57,975
$
57,975
$

$

December 31, 2019
Assets:
Cash equivalents
$
3,891
$
3,891
$

$

Total assets
$
3,891
$
3,891
$

$

Cash equivalents of $57,975 and $3,891 as of September 30, 2020 and December 31, 2019, respectively, consisted of overnight investments and money market funds and are classified within Level 1 of the fair value hierarchy because they are valued using quoted market prices in active markets.
The carrying value of the research and development incentive receivable, accounts payable and accrued liabilities approximate their fair value due to the short-term nature of these assets and liabilities.
Leases
In February 2016, the Financial Accounting Standards Board, or FASB, issued ASU 2016-02, Leases, or ASU 2016-02, to enhance the transparency and comparability of financial reporting related to leasing arrangements. The Company adopted ASU 2016-02 on January 1, 2019, or the effective date, and used the effective date as its date of initial application.
At the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the unique facts and circumstances present. Most leases with a term greater than one year are recognized on the balance sheet as right-of-use assets, lease liabilities and, if applicable, long-term lease liabilities. The Company has elected not to recognize on the balance sheet leases with terms of one year or less. Operating lease liabilities and their corresponding right-of-use assets are recorded based on the present value of lease payments over the expected remaining lease term. The Company has determined that the rate implicit in the lease is not determinable and the Company does not have borrowings with similar terms and collateral. Therefore, the Company considered a variety of factors, including observable debt yields from comparable companies and the volatility in the debt market for securities with similar terms, in determining that 8% was reasonable to use as the incremental borrowing rate for purposes of the calculation of lease liabilities.
In accordance with the guidance in ASU 2016-02, components of a lease should be split into three categories: lease components (e.g. land, building, etc.), non-lease components (e.g. common area maintenance, maintenance, consumables, etc.), and non-components (e.g. property taxes, insurance, etc.). Then the fixed and in-substance fixed contract consideration (including any related to non-components) must be allocated based on fair values to the lease components and non-lease components.
Although separation of lease and non-lease components is required, certain practical expedients are available. Entities may elect the practical expedient to not separate lease and non-lease components. Rather, they would account for each lease component and the related non-lease component together as a single component. The Company has elected to account for the lease and non-lease components of each of its operating leases as a single lease component and allocate all of the contract consideration to the lease component only. The lease component results in an operating right-of-use asset being recorded on the consolidated balance sheets and amortized such that lease expense is recorded on a straight line basis over the term of the lease.
Revenue Recognition
The Company records revenue in accordance with Accounting Standards Codification, or ASC, Topic 606, Revenue From Contracts with Customers. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Under Topic 606, an entity recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that an entity determines are within the scope of Topic 606, the entity performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. The Company only applies the five step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied.
License revenue. The Company’s performance obligations under its license agreements may include providing intellectual property licenses, performing technology transfer, performing research and development consulting services and notifying the customer of any enhancements to licensed technology or new technology that it discovers, among others. The Company determined that its performance obligations under its license agreements as evaluated at contract inception were not distinct and represented a single performance obligation. Upfront payments are amortized to revenue on a straight-line basis over the performance period. Upfront payment contract liabilities resulting from the Company’s license agreements do not represent a financing component as the payment is not financing the transfer of goods or services, and the technology underlying the licenses granted reflects research and development expenses already incurred by the Company. Generally, all amounts received or due other than sales-based milestones and royalties are classified as license revenues. Sales-based milestones and royalties under the Company’s license agreements will be recognized as royalty revenue in the period the related sale occurred. The Company generally invoices its licensees upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of the culmination of the earnings process and is recognized as revenue in future periods as performance obligations are satisfied. Deferred revenue expected to be recognized within the next twelve months is classified as a current liability.
Research and Development Services. The promises under the Company's license agreements may include research and development services to be performed by the Company on behalf of the customer. Payments or reimbursements resulting from the Company's research and development efforts are recognized as the services are performed and presented on a gross basis because the Company is the principal for such efforts.
Customer Options. If an arrangement is determined to contain customer options that allow the customer to acquire additional goods or services, the goods and services underlying the customer options that are not determined to be material rights are not considered to be performance obligations at the outset of the arrangement, as they are contingent upon option exercise. The Company evaluates the customer options for material rights, or options to acquire additional goods or services for free or at a discount. If the customer options are determined to represent a material right, the material right is recognized as a separate performance obligation at the outset of the arrangement. The Company allocates the transaction price to material rights based on the relative standalone selling price, which is determined based on the identified discount and the probability that the customer will exercise the option. Amounts allocated to a material right are not recognized as revenue until (1) the option is exercised and the additional goods or services are transferred or (2) the option expires.
Milestone Payments. At the inception of each arrangement that includes research or development milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be overcome to achieve the particular milestone in making this assessment. There is considerable judgment involved in determining whether it is probable that a significant revenue reversal would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment.
Royalties . For arrangements that include sales-based royalties, including milestone payments upon first commercial sales and milestone payments based on a level of sales, which are the result of a customer-vendor relationship and for which the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied or partially satisfied. To date, the Company has not recognized any royalty revenue resulting from any of its licensing arrangements.
Collaborative Arrangements
The Company analyzes its collaboration arrangements to assess whether such arrangements involve joint operating activities performed by parties that are both active participants in the activities and exposed to significant risks and rewards dependent on the commercial success of such activities and therefore within the scope of ASC Topic 808, Collaborative Arrangements (ASC 808). This assessment is performed throughout the life of the arrangement based on changes in the responsibilities of all parties in the arrangement. For collaboration arrangements within the scope of ASC 808 that contain multiple elements, the Company first determines which elements of the collaboration are deemed to be within the scope of ASC 808 and which elements of the collaboration are more reflective of a vendor-customer relationship and therefore within the scope of ASC 606. For elements of collaboration arrangements that are accounted for pursuant to ASC 808, an appropriate recognition method is determined and applied consistently, generally by analogy to ASC 606. Amounts that are owed to collaboration partners are recognized as an offset to collaboration revenues as such amounts are incurred by the collaboration partner. Where amounts owed to a collaboration partner exceed the Company's collaboration revenues in each quarterly period, such amounts are classified as research and development expense. Reimbursements from and payments to the customer that are the result of a collaborative relationship with a partner, instead of a customer relationship, such as co-development activities, are recorded as a reduction to research and development expense. For those elements of the arrangement that are accounted for pursuant to ASC 606, the Company applies the five-step model described above under ASC 606.
See Note 3 for a complete discussion of the revenue recognition for the Company's license agreement.
Net Loss per Share
Basic net loss per share is computed using the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed using the weighted average number of common shares outstanding during the period and, if dilutive, the weighted average number of potential shares of common stock, including the assumed exercise of stock options and warrants.
Subsequent Events
The Company considers events or transactions that occur after the balance sheet date but prior to the issuance of the financial statements to provide additional evidence for certain estimates or to identify matters that require additional disclosure. Subsequent events have been evaluated as required.
Recent Accounting Pronouncements
From time to time, new accounting pronouncements are issued by the FASB, and are early adopted by the Company or adopted as of the specified effective date.
In November 2018, the FASB issued “ASU 2018-18, Clarifying the Interaction between Topic 808 and Topic 606.” The objective of the standard is to clarify the interaction between ASC Topic 808--Collaborative Arrangements and ASC Topic 606--Revenue from Contracts with Customers. Currently, ASC Topic 808 does not provide comprehensive recognition or measurement guidance for collaborative arrangements, and the accounting for those arrangements is often based on an analogy to other accounting literature or an accounting policy election. Similarly, aspects of ASC Topic 606 have resulted in uncertainty in practice about the effect of the revenue standard on the accounting for collaborative arrangements. The standard became effective for us beginning on January 1, 2020 and the adoption of this ASU did not have a material impact on our financial condition, results of operations, cash flows, and financial statement disclosures.

BeiGene Exclusive Option and Li

BeiGene Exclusive Option and License Agreement9 Months Ended
Sep. 30, 2020
BeiGene Exclusive Option and License Agreement
BeiGene Exclusive Option and License Agreement3. BeiGene Exclusive Option and License Agreement
Terms of Agreement
On January 3, 2020, the Company entered into an exclusive option and license agreement (the "BeiGene Agreement") with BeiGene, Ltd. ("BeiGene") for the clinical development and commercialization of DKN-01, in Asia (excluding Japan), Australia, and New Zealand. The Company retains exclusive rights for the development, manufacturing, and commercialization of DKN-01 for the rest of the world.
Pursuant to the BeiGene Agreement, the Company received an upfront cash payment of $3,000 from BeiGene in exchange for granting BeiGene an option to an exclusive license to develop and commercialize DKN-01 in Asia (excluding Japan), Australia, and New Zealand. The Company is eligible to receive up to $132,000 in future option exercise and milestone payments, based upon the achievement of certain development, regulatory, and sales milestones, as well as tiered royalties on any product sales of DKN-01 in the licensed territory.
The Company is responsible for conducting development activities prior to the exercise of the option. After the option is exercised, BeiGene is solely responsible for the development and commercialization of DKN-01 in the territory. The BeiGene Agreement continues in effect until the earlier of: (i) 120 days after the end of the option period, if BeiGene has not exercised the option by such date; and (ii) on a country-by country and Licensed Product-by-Licensed Product (as defined in the BeiGene Agreement) basis, the expiration of the Royalty Term (as defined in the BeiGene Agreement) applicable to such licensed product in such country. At any time, BeiGene may terminate the agreement by providing at least 60 days written notice of termination to the Company. Upon termination of the License Agreement, all rights granted by the Company to BeiGene terminate.
Revenue Recognition
The Company evaluated the BeiGene Agreement to determine whether it is a collaborative arrangement for purposes of ASC 808. The Company concluded that because both parties were active participants and were exposed to the risks and rewards of the BeiGene Agreement, that such activities are under the scope of ASC 808. The Company concluded that BeiGene was a customer with regard to the combined license and research and development activities and as such the contract should be evaluated under ASC 606.
In determining the appropriate amount of revenue to be recognized under ASC 606 as the Company fulfills its obligations under the Agreement, the Company performs the following steps: (i) identifies the promised goods or services in the contract; (ii) determines whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measures the transaction price, including any constraints on variable consideration; (iv) allocates the transaction price to the performance obligations; and (v) recognizes revenue when (or as) the Company satisfies each performance obligation.
The Company identified the following material promises under the BeiGene Agreement: (1) option to an exclusive license to develop and commercialize DKN-01 in Asia (excluding Japan), Australia, and New Zealand, (2) participation in a joint development committee, (3) technology transfer services and (4) pre-option research and development services. The Company determined that the option to an exclusive license in the territory does not represent a material right. Additionally, the Company determined that the participation in the joint development committee, research and development services and technology transfer services are not distinct from each other, as each has limited value without the other. As such, for the purposes of ASC 606, the Company determined that these four material promises, described above, should be combined into a single performance obligation.
The Company determined the transaction price is equal to the up-front fee of $3,000. The transaction price was fully allocated to the single performance obligation and is recognized as revenue on a straight-line basis over the performance period of the research and development services . During the three and nine months ended September 30, 2020, the Company recognized $375 and $1,125, respectively, of license revenue related to the up-front fee received from BeiGene. The Company did not have any such license revenue during the three and nine months ended September 30, 2019.
Cost of contract acquisition
The Company incurred contract acquisition costs of $270 which were capitalized under ASC 340-40 as incremental costs of obtaining the contract with BeiGene. This cost is amortized on a straight-line basis over the performance period of the research and development services. The total amount of amortization expense during the three and nine months ended September 30, 2020 was $34 and $101, respectively, and the closing balance recorded in deferred costs as of September 30, 2020 was $169.
Royalties
As the license is deemed to be the predominant item to which sales-based royalties relate, the Company will recognize revenue when the related sales occur. No royalty revenue was recognized during the three and nine months ended September 30, 2020.
The following table presents a summary of the activity in the Company's contract liabilities, related to the upfront cash payment received of $3,000, during the nine months ended September 30, 2020 (in thousands):
Balance at
Balance at
January 1,2020
Additions
Deductions
September 30, 2020
Contract liabilities
Deferred revenue - current
$

$
1,500
$

$
1,500
Deferred revenue - non current

1,500
(1,125)
375
Total contract liabilities
$

$
3,000
$
(1,125)
$
1,875

Accrued Expenses

Accrued Expenses9 Months Ended
Sep. 30, 2020
Accrued Expenses
Accrued Expenses4. Accrued Expenses
Accrued expenses consist of the following:
September 30,
December 31,
2020
2019
Clinical trials
$
1,049
$
1,828
Professional fees
191
609
Payroll and related expenses
1,030
1,004
Accrued expenses
$
2,270
$
3,441

Leases

Leases9 Months Ended
Sep. 30, 2020
Leases
Leases5. Leases
In February 2016, the FASB issued ASU 2016-02, Leases, or ASU 2016-02. ASU 2016-02 requires a lessee to recognize on its balance sheet (for both finance and operating leases) a liability to make lease payments and a right-of-use asset representing its right to use the underlying asset for the lease term. The Company adopted ASU 2016-02 on January 1, 2019, on the effective date, and used the effective date as its date of initial application. As such, the Company did not adjust prior period amounts. The Company also elected to adopt the practical expedients upon transition, which permit companies to not reassess lease identification, classification, and initial direct costs under ASU 2016-02 for leases that commenced prior to the effective date.
The Company has operating leases for real estate in the United States and does not have any finance leases. The Company’s leases may contain options to renew and extend lease terms and options to terminate leases early. Reflected in the right-of-use asset and lease liability on the Company’s consolidated balance sheets are the periods provided by renewal and extension options that the Company is reasonably certain to exercise, as well as the periods provided by termination options that the Company is reasonably certain to not exercise.
The Company has existing leases that include variable lease and non-lease components that are not included in the right-of-use asset and lease liability and are reflected as an expense in the period incurred. Such payments primarily include common area maintenance charges and increases in rent payments that are driven by factors such as future changes in an index (e.g., the Consumer Price Index).
In calculating the present value of future lease payments, the Company utilized its incremental borrowing rate based on the remaining lease term at the date of adoption. The Company has elected to account for each lease component and its associated non-lease components as a single lease component and has allocated all of the contract consideration across lease components only. This will potentially result in the initial and subsequent measurement of the balances of the right-of-use asset and lease liability for leases being greater than if the policy election was not applied. The Company has existing net leases in which the non-lease components (e.g. common area maintenance, maintenance, consumables, etc.) are paid separately from rent based on actual costs incurred and therefore are not included in the right-of-use asset and lease liability and are reflected as an expense in the period incurred. On January 1, 2019, the Company recorded a right-of-use asset of $1,720 and a lease liability of $1,720 on its consolidated balance sheets and reclassified prepaid rent to the right-of-use asset of $35. As of September 30, 2020, a right-of-use asset of $620 and lease liability of $648 are reflected on the condensed consolidated balance sheets. The Company recorded rent expense of $105 and $211, respectively, during the three months ended September 30, 2020 and 2019 and $445 and $629, respectively, for the nine months ended September 30, 2020.
Future lease payments under non-cancelable operating leases as of September 30, 2020 are detailed as follows:
Future Operating Lease Payments
2020
$
107
2021
434
2022
146
Total Lease Payments
687
Less: imputed interest
(39)
Total operating lease liabilities
$
648

Warrants

Warrants9 Months Ended
Sep. 30, 2020
Warrants
Warrants6. Warrants
As of September 30, 2020, outstanding warrants to purchase common stock, all of which are classified as equity warrants, consisted of the following:
September 30, 2020
Date
Number of Shares
Exercisable
Issuable
Exercise Price
1/23/2017
54,516
$
11/14/2017
2,549,840
$
1.055
2/5/2019
7,491,442
$
1.95
3/5/2020
14,413,902
$
0.001
3/5/2020
25,945,035
$
2.11
6/22/2020
2,250,000
$
0.001
52,704,735
2017 Warrants
The 2017 Warrants contain full ratchet anti-dilution protection provisions. Prior to January 1, 2019, the Company classified the 2017 Warrants as a liability on its consolidated balance sheet because each warrant represented a freestanding financial instrument that, due to the potential variable nature of the exercise price, is not considered to be indexed to the Company’s own shares. The warrant liability was initially recorded at fair value upon entering into the November 2017 Private Placement and has been subsequently remeasured to fair value at each reporting date. Changes in the fair value of the warrant liability were recognized as gains (losses) in the Company’s consolidated statement of operations.
On January 1, 2019, the Company adopted ASU 2017-11 and concluded that the 2017 Warrants now qualify for equity classification. The Company applied the guidance retrospectively to the 2017 Warrants by means of a cumulative-effect adjustment to its statement of financial position as of the beginning of the interim and annual period beginning January 1, 2019. The Company performed a final remeasurement of the warrant liability as of January 1, 2019 and reclassified $3,448 to additional paid in capital.
The Company will recognize on a prospective basis the value of the effect of the down round feature in the warrant when it is triggered (i.e., when the exercise price is adjusted downward). This value is measured as the difference between (1) the financial instrument’s fair value (without the down round feature) using the pre-trigger exercise price and (2) the financial instrument’s fair value (with the down round feature) using the reduced exercise price. The value of the effect of the down round feature will be treated as a dividend and a reduction to income available to common stockholders in the basic EPS calculation. In connection with the 2019 Public Offering, when the 2017 Warrants were repriced from $6.085 to $1.75, the Company recorded a dividend of $359 during the nine months ended September 30, 2019. In connection with the January 2020 Private Placement, when the 2017 Warrants were repriced from $1.75 to $1.055, the Company recorded a dividend of $303 during the nine months ended September 30, 2020.
During the nine months ended September 30, 2020, 208,254 of 2017 Warrants were exercised for cash resulting in gross proceeds to the Company of $220.
2019 Warrants
On February 5, 2019, in connection with the 2019 Public Offering, the Company issued immediately exercisable warrants (the “2019 Warrants”) to purchase 7,557,142 shares of common stock to investors. The 2019 Warrants have an exercise price of $1.95 per share and expire on February 5, 2026. The 2019 Warrants qualify for equity classification.
During the nine months ended September 30, 2020, 65,700 of 2019 Warrants were exercised for cash resulting in gross proceeds to the Company of $128.
March 2020 Warrants
On January 3, 2020, the Company entered into a Securities Purchase Agreement with investors, providing for a private placement transaction exempt from the Securities Act of 1933, as amended, pursuant to which the Company issued and sold 1,421,801 shares of its Series A Preferred Stock, at a purchase price of $10.54 per share, and 1,137,442 shares of its Series B Preferred Stock at a purchase price of $10.55 per share, and one (1) share of the Company's Special Voting Stock entitling the purchaser of Series A Preferred Stock to elect one member of the Company's board of directors.
On March 5, 2020, the Company's stockholders approved the conversion of the Series A Preferred Stock into a pre-funded warrant to purchase 14,413,902 shares of common stock at an exercise price of $0.001 (the “March 2020 Pre-funded Warrants”) and the conversion of the Series B Preferred Stock into 11,531,133 shares of common stock. Each investor also received a warrant to purchase an equal number of shares of common stock at an exercise price of $2.11 per share (the “Coverage Warrants”). The March 2020 Pre-funded Warrants and the Coverage Warrants expire on March 5, 2027 and qualify for equity classification.
June 2020 Warrants
On June 22, 2020, the Company completed a Public Offering ("the 2020 Public Offering") whereby the Company issued 20,250,000 shares of its common stock, at $2.00 per share and, in lieu of common stock, offered pre-funded warrants (the "June 2020 Pre-funded Warrants") to purchase up to 2,250,000 shares of its common stock to certain investors. The June 2020 Pre-funded Warrants have an exercise price of $0.001 per share, expire on June 22, 2027 and qualify for equity classification.

Common Stock

Common Stock9 Months Ended
Sep. 30, 2020
Common Stock
Common Stock7. Common Stock
Each share of common stock entitles the holder to one vote on all matters submitted to a vote of the Company’s stockholders. Common stockholders are entitled to receive dividends, as may be declared by the board of directors, if any, subject to the preferential dividend rights of the preferred stockholders. Through September 30, 2020, no dividends have been declared for shares of common stock.
Public Offering of Common Stock — February 2019
On February 5, 2019, the Company completed the 2019 Public Offering whereby the Company issued 7,557,142 shares of its common stock at a price of $1.75 per share, which included 985,714 shares issued pursuant to the underwriters’ exercise of their option to purchase additional shares of common stock, each share was issued with a warrant to purchase one share of common stock. Each warrant has an exercise price of $1.95 per share with an exercise period expiring seven years from the date of issuance. The aggregate net proceeds received by the Company from the 2019 Public Offering were approximately $12,122, net of underwriting discounts and commissions and estimated offering expenses payable by the Company.
Issuance of Common Stock under Distribution Agreement
On September 7, 2018, the Company filed a Prospectus Supplement to register the offer and sale of shares of common stock having an aggregate offering price of up to $30,000 pursuant to the terms of a distribution agreement, or the Distribution Agreement, with Raymond James & Associates, Inc. During the year ended December 31, 2019, the Company issued 1,033,147 shares under the Distribution Agreement, for net proceeds of $1,923. In June 2020, the Company terminated the Distribution Agreement and did not issue any shares under the Distribution Agreement during the nine months ended September 30, 2020.
Lincoln Park Purchase Agreements
On July 10, 2019, the Company entered into a Commitment Purchase Agreement and a Registration Rights Agreement with Lincoln Park, pursuant to which the Company has the right to sell to Lincoln Park up to $20,000 in shares of its common stock, subject to certain limitations and conditions set forth in the Commitment Purchase Agreement. As consideration for Lincoln Park’s commitment to purchase shares of common stock pursuant to the Commitment Purchase Agreement, the Company issued to Lincoln Park 330,000 shares of common stock. The Company did not receive any cash proceeds from the issuance of such shares. During the three and nine months ended September 30, 2020, the Company did not issue any shares under the Commitment Purchase Agreement .
On July 11, 2019, the Company entered into a Registered Offering Purchase Agreement, under which the Company agreed to sell to Lincoln Park, and Lincoln Park agreed to purchase 571,429 shares of common stock, at a price of $1.75 per share for an aggregate purchase price of $1,000, pursuant to the Company’s effective shelf Registration Statement on Form S-3, including the prospectus supplement thereto dated July 11, 2019.
January 2020 Private Placement
On January 3, 2020, the Company issued and sold 1,421,801 shares of its Series A Preferred Stock at a purchase price of $10.54 per share, and 1,137,442 shares of its Series B Preferred Stock at a purchase price of $10.55 per share, and one (1) share of its Special Voting Stock, entitling the purchaser of Series A Preferred Stock to elect one member of the Company’s board of directors, for aggregate net proceeds to the Company of approximately $25,322.
On March 5, 2020, the Company’s stockholders approved the conversion of the Series A Preferred Stock into a pre-funded warrant to purchase 14,413,902 shares of common stock at an exercise price of $0.001 per share and the conversion of the Series B Preferred Stock into 11,531,133 shares of its common stock, par value $0.001 per share. Each investor also received the Coverage Warrants to purchase an equal number of shares at an exercise price of $2.11 per share.
In connection with the January 2020 Private Placement, Series A Preferred Stock holders and Series B Preferred Stock holders were entitled to cash dividends at fixed cumulative percentage of 8% per annum plus any dividends declared on outstanding common stock on an as-converted basis, effective on the issuance date of the Series A Preferred Stock and Series B Preferred Stock. The cash dividends were converted to shares of common stock upon the conversion of the Series A Preferred Stock to pre-funded warrants and Series B Preferred Stock to common stock. During the nine months ended September 30, 2020, the Company recorded $372 of Series A Preferred Stock and Series B Preferred Stock dividends, which qualify as cumulative dividends, and in the calculation of EPS are subtracted from net income in arriving at income attributable to common stockholders.
The Company determined that the embedded conversion features of the Series A Preferred Stock and Series B Preferred Stock to receive the Coverage Warrants each met the definition of a contingent beneficial conversion feature and should be accounted for separately as a derivative. The recognition of the beneficial conversion feature occurred upon the conversion of the Series A Preferred Stock into pre-funded warrants and Series B Preferred Stock into common stock and the issuance of the Coverage Warrants. The Company measured the contingent beneficial conversion features’ intrinsic values on January 3, 2020 and determined that the beneficial conversion features were valued at $5,226 for Series A and $4,173 for Series B, respectively. Upon conversion, the discount originated by the contingent beneficial conversion feature, at its intrinsic value for Series A Preferred Stock and Series B Preferred Stock, was immediately recognized as a dividend. The dividend is reflected as an adjustment to basic and diluted net loss per share attributable to common stockholders.
Public Offering of Common Stock – June 2020
On June 22, 2020, the Company completed the 2020 Public Offering, whereby the Company issued 20,250,000 shares of its common stock at $2.00 per share and, in lieu of common stock, issued certain investors 2,250,000 of its June 2020 Pre-funded Warrants. The June 2020 Pre-funded Warrants have an exercise price of $0.001 per share, expire on June 22, 2027 and qualify for equity classification.
On June 25, 2020, the underwriters exercised their right to purchase 3,375,000 additional shares of the Company’s common stock at the public offering price per share of common stock, less underwriting discounts and commissions. The aggregate net proceeds received by the Company from the 2020 Public Offering were approximately $48,276, net of underwriting discounts and commissions and estimated offering expenses payable by the Company.

Equity Incentive Plans

Equity Incentive Plans9 Months Ended
Sep. 30, 2020
Equity Incentive Plans
Equity Incentive Plans8 . Equity Incentive Plans
Equity Incentive Plans
In September 2012, the Company adopted the 2012 Equity Incentive Plan, as amended (the “Plan”), which provides designated employees of the Company and its affiliates, certain consultants and advisors who perform services for the Company and its affiliates, and nonemployee members of the board of directors of the Company and its affiliates with the opportunity to receive grants of incentive stock options, nonqualified stock options and stock awards.
On January 20, 2017, the Company’s stockholders approved the 2016 Equity Incentive Plan (the “2016 Plan”). Beginning on January 1, 2018, the number of shares of common stock authorized for issuance pursuant to the 2016 Plan was increased each January 1 by an amount equal to four percent (4%) of the Company’s outstanding common stock as of the end of the immediately preceding calendar year or such other amount as determined by the compensation committee of the Company’s board of directors. In 2019, the board of directors and the stockholders approved and authorized an additional 3,000,000 shares of common stock to be added to the shares authorized for issuance under the 2016 Plan.
As of September 30, 2020, there were 455,144 shares available for grant under the Company’s equity incentive plans.
A summary of stock option activity under the Equity Plans is as follows:
Weighted
Average
Weighted
Aggregate
Exercise Price
Average Remaining
Intrinsic
Options
Per Share
Life in Years
Value
Outstanding at December 31, 2019
4,024,566
$
7.48
7.98
$
2
Granted
2,547,500
$
2.12
Exercised
(32,778)
$
1.53
Forfeited
(260,435)
$
6.95
Outstanding at September 30, 2020
6,278,853
$
5.35
$
1,082
Options exercisable at September 30, 2020
3,113,663
$
8.45
$
359
Options vested and expected to vest at September 30, 2020
6,278,853
$
5.35
$
1,082
The grant date fair value of the options granted during the year ended December 31, 2019 and the nine months ended September 30, 2020, was estimated at the date of grant using the Black-Scholes option valuation model. The expected life was estimated using the “simplified” method as defined by the SEC's Staff Accounting Bulletin 107, Share-Based Payment. The expected volatility was based on the historical volatility of comparable public companies from a representative peer group selected based on industry and market capitalization data. The risk-free interest rate was based on the continuous rates provided by the U.S. Treasury with a term approximating the expected life of the option. The expected dividend yield was 0% because the Company does not expect to pay any dividends for the foreseeable future. The Company elected the straight-line attribution method in recognizing the grant date fair value of options issued over the requisite service periods of the awards, which are generally the vesting periods.
The assumptions that the Company used to determine the grant-date fair value of stock options granted to employees and directors during the year ended December 31, 2019 and the nine months ended September 30, 2020 were as follows, presented on a weighted average basis:
Nine Months
Year Ended
Ended September 30,
December 31,
2020
2019
Expected volatility
66.94
%
66.94
%
Weighted average risk-free interest rate
0.66
%
%
Expected dividend yield
0.00
%
0.00
%
Expected term (in years)
6.77
Stock options generally vest over a three or four year period, as determined by the compensation committee of the board of directors at the time of grant. The options expire ten years from the grant date. As of September 30, 2020, there was approximately $4,453 of unrecognized compensation cost related to non-vested stock options, which is expected to be recognized over a remaining weighted-average period of approximately 2.21 years.
The Company recognized stock-based compensation expense related to the issuance of stock option awards to employees and non-employees in the condensed consolidated statements of operations as follows:
Three Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Research and development
$
282
$
181
$
720
$
536
General and administrative
309
769
967
2,260
Total
$
591
$
950
$
1,687
$
2,796
Restricted Stock Units
During the nine months ended September 30, 2020 and 2019, the Company issued 92,500 and 181,000 restricted stock units ("RSUs"), respectively, to employees under the 2016 Plan. Upon vesting of the RSUs, the Company has the option to settle the award by either issuing shares of the Company's common stock or paying an amount of cash equal to the fair value of the Company's common stock on the settlement date. In each of October 2019 and January 2020, the Company cash settled 90,500 RSUs. As of September 30, 2020 and December 31, 2019, these RSUs are classified as restricted stock liability in the condensed consolidated balance sheets of $66 and $159, respectively, as they contain a cash settlement option.
During the nine months ended September 30, 2020, the Company granted 660,606 RSUs to an executive officer that will cliff vest and will be settled after three years of continuous service, or upon a change of control of the Company, whichever is earlier, pursuant to the 2016 Plan. During the nine months ended September 30, 2020, the Company recognized $170 of stock based compensation expense related to equity classified RSUs, as they do not contain a cash settlement option.
The following table presents a summary of outstanding RSUs under the 2016 Plan as of September 30, 2020:
Weighted
Average
Number of
Grant Date
Shares
Fair Value
Outstanding at December 31, 2019
90,500
$
1.74
Awarded
753,106
$
1.49
Settled in cash
(90,500)
$
1.74
Outstanding at June 30, 2020
753,106
$
1.49
As of September 30, 2020, there were 753,106 shares outstanding covered by RSUs that are expected to vest. The weighted average grant date fair value of these shares of restricted stock was $1.49 per share and the aggregate grant date fair value of these shares of restricted stock was approximately $1,112. As of September 30, 2020, there was approximately $884 of unrecognized compensation costs related to RSUs granted to employees, which are expected to be recognized as expense over a remaining weighted average period of 2.17 years.

Net Loss Per Share

Net Loss Per Share9 Months Ended
Sep. 30, 2020
Net Loss Per Share
Net Loss Per Share9. Net Loss Per Share
Basic and diluted net loss per share for the three and nine months ended September 30, 2020 and 2019 was calculated as follows (in thousands except share and per share amounts).
Three Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Numerator:
Net loss
$
(7,057)
$
(7,935)
$
(20,804)
$
(24,904)
Dividend attributable to down round feature of warrants


(303)
(359)
Dividend attributable to Series A & B convertible preferred stock


(372)

Series A & B convertible preferred stock - beneficial conversion feature


(9,399)

Net loss attributable to common stockholders for basic and diluted loss per share
$
(7,057)
$
(7,935)
$
(30,878)
$
(25,263)
Denominator:
Weighted average number of common shares outstanding – basic and diluted
76,321,644
23,923,196
53,548,902
22,039,386
Net loss per share attributable to common stockholders – basic and diluted
$
(0.09)
$
(0.33)
$
(0.58)
$
(1.15)
Included within weighted average common shares outstanding are 16,663,902 common shares issuable upon the exercise of the pre-funded warrants as the warrants are exercisable at any time for nominal consideration, and as such, the shares are considered outstanding for the purpose of calculating basic and diluted net loss per share attributable to common stockholders.
The Company’s potentially dilutive securities include RSUs, stock options and warrants. These securities were excluded from the computations of diluted net loss per share for the three and nine months ended September 30, 2020 and 2019, as the effect would be to reduce the net loss per share. The following table includes the potential shares of common stock, presented based on amounts outstanding at each period end, that were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect:
Three Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Restricted stock units to purchase common stock
753,106

753,106

Options to purchase common stock
6,278,853
4,019,566
6,278,853
4,019,566
Warrants to purchase common stock
36,040,833
10,369,752
36,040,833
10,369,752
43,072,792
14,389,318
43,072,792
14,389,318

Commitments and Contingencies

Commitments and Contingencies9 Months Ended
Sep. 30, 2020
Commitments and Contingencies
Commitments and Contingencies10. Commitments and Contingencies
Manufacturing Agreements —The Company is party to manufacturing agreements with vendors to manufacture DKN‑01, its lead product candidate, for use in clinical trials. As of September 30, 2020, there were $381 noncancelable commitments under these agreements.
License and Service Agreement —On January 3, 2011, the Company entered into a license agreement with Eli Lilly and Company (“Lilly”), a shareholder, to grant a license to the Company for certain intellectual property rights relating to pharmaceutically active compounds that may be useful in the treatment of bone healing, cancer and, potentially, other medical conditions. As defined in the license agreement, the Company would be required to pay royalties to Lilly based upon a percentage in the low single digits of net sales of developed products, if and when achieved. However, there can be no assurance that clinical or commercialization success of developed products will occur, and no royalties have been paid or accrued through September 30, 2020.
License Agreement —On May 28, 2015, the Company entered into a license agreement with Lonza Sales AG (“Lonza”), pursuant to which Lonza granted the Company a world-wide, non-exclusive license for certain intellectual property relating to a gene expression system for manufacturing DKN‑01. As defined in the license agreement, the Company would be required to pay royalties to Lonza based on a percentage in the low single digits of net sales of DKN‑01, if and when achieved. However, there can be no assurance that clinical or commercialization success will occur, and no royalties have been paid or accrued through September 30, 2020.
Legal Proceedings —At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses as incurred the costs related to its legal proceedings.
A patent covering the TRX518 antibody and its uses in methods of inducing or enhancing an immune response in a subject was granted in 2013 to the Company by the European Patent Office (EPO). Three notices of opposition to this patent were filed: two by major pharmaceutical companies and a third by an individual, possibly on behalf of a major pharmaceutical company. At the conclusion of the opposition proceedings before the Opposition Division of the EPO, the Opposition Division issued a decision indicating that the Company’s patent was maintained with modified claims that differ from the claims as originally granted. These narrowed claims cover the TRX518 antibody and uses of the TRX518 antibody in methods of inducing or enhancing an immune response in a subject. The Company filed an appeal of the decision of the Opposition Division seeking to obtain broader claims that more closely reflect the claims as granted in the patent. A hearing before the EPO Boards of Appeal took place on September 16, 2020, which resulted in the Boards of Appeal dismissing the appeal and maintaining the Decision of the Opposition Division. A written Decision by the Boards of Appeal was issued on September 25, 2020.
In 2016, a patent covering the use of the TRX518 antibody in combination with a chemotherapeutic agent for treating cancer was granted to the Company by the EPO. In March 2017, notices of opposition to this patent were filed at the EPO by ten different entities, including several major pharmaceutical companies. Oral proceedings at the EPO took place on December 4 and 5, 2018. At the conclusion of the oral proceedings, the Opposition Division decided that the patent should be revoked in its entirety on the ground that the claims as granted contained added matter. Subsequently, the Opposition Division issued an interlocutory decision restating its conclusion that the claims as granted contained added matter and revoking the patent. The Company has filed an appeal of the decision of the Opposition Division seeking to obtain a reversal of the Opposition Division’s decision on added matter. The EPO Board of Appeal has not yet scheduled the appeal hearing.
In December of 2019, a patent covering the use of the TRX518 antibody in combination with the chemotherapeutic agent, gemcitabine, for treating a colon tumor or adenocarcinoma of the colon, was granted to the Company by the EPO. A Notice of Opposition was filed against the patent by a single opponent, Sanofi, on September 25, 2020. The EPO issued a Communication on October 9, 2020 setting a deadline of February 9, 2021 for the Patentee to file a response to the Notice of Opposition. Oral proceedings at the EPO have not yet been scheduled.
Indemnification Agreements —In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any claims under indemnification arrangements, and it has not accrued any liabilities related to such obligations in its condensed consolidated financial statements as of September 30, 2020 or December 31, 2019.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)9 Months Ended
Sep. 30, 2020
Summary of Significant Accounting Policies
Principles of ConsolidationPrinciples of Consolidation
The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions are eliminated upon consolidation.
Use of EstimatesUse of Estimates
The presentation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
Research and development incentive income and receivableResearch and development incentive income and receivable
The Company recognizes other income from Australian research and development incentives when there is reasonable assurance that the income will be received, the relevant expenditure has been incurred, and the consideration can be reliably measured. The research and development incentive is one of the key elements of the Australian Government’s support for Australia’s innovation system and is supported by legislative law primarily in the form of the Australian Income Tax Assessment Act 1997, as long as eligibility criteria are met.
Management has assessed the Company’s research and development activities and expenditures to determine which activities and expenditures are likely to be eligible under the research and development incentive regime described above. At each period end, management estimates the refundable tax offset available to the Company based on available information at the time. This estimate is also reviewed by external tax advisors on an annual basis.
Under the program, a percentage of eligible research and development expenses incurred by the Company through its subsidiary in Australia are reimbursed. The percentage was 43.5% for the year ended December 31, 2019 and for the three and nine months ended September 30, 2020.
The research and development incentive receivable represents an amount due in connection with the above program. The Company has recorded a research and development incentive receivable of $209 and $185 as of September 30, 2020 and December 31, 2019, respectively, in the condensed consolidated balance sheets and other income from Australian research and development incentives of $228 for the three months ended September 30, 2020. During the three months ended September 30, 2019, the Australian research and development incentives recognized were offset by an adjustment to the prior year estimated Australian research and development incentives, resulting in a net expense for the period. During the three months ended September 30, 2020, the Company recorded an adjustment to increase Australian research and development incentive income by approximately $150 as the cash received from the Australian Government during the three months ended September 30, 2020 for 2019 eligible expenditures was higher than the prior year estimated Australian research and development incentives. During the nine months ended September 30, 2020 and 2019, the Company recorded $343 and $129, respectively, of other income from Australian research and development incentives.
The following table shows the change in the research and development incentive receivable from December 31, 2018 to September 30, 2020 (in thousands):
Balance at December 31, 2018
$
836
Australian research and development incentive income, net
132
Cash received for 2018 eligible expenses
(757)
Foreign currency translation
(26)
Balance at December 31, 2019
185
Australian research and development incentive income, net
343
Cash received for 2019 eligible expenses
(331)
Foreign currency translation
12
Balance at September 30, 2020
$
209
Foreign Currency TranslationForeign Currency Translation
The financial statements of the Company’s Australian subsidiary are measured using the local currency as the functional currency. Assets and liabilities of this subsidiary are translated into U.S. dollars at an exchange rate as of the consolidated balance sheet date. Equity is translated at historical exchange rates. Revenues and expenses are translated into U.S. dollars at average rates of exchange in effect during the period. The resulting cumulative translation adjustments have been recorded as a separate component of stockholders’ equity. Realized foreign currency transaction gains and losses are included in the results of operations.
Deferred CostsDeferred Costs
The Company capitalizes certain legal, professional, accounting and other third-party fees that are directly associated with in-process equity financings as deferred costs until such financings are consummated. After consummation of the equity financing, these costs are recorded in stockholders’ equity (deficiency) as a reduction of additional paid-in capital generated as a result of the offering.
The Company also capitalizes certain contract acquisition costs. During the nine months ended September 30, 2020, the Company incurred contract acquisition costs which were capitalized under ASC 340-40 as incremental costs of obtaining the contract with BeiGene. This cost is amortized on a straight-line basis over the performance period of the research and development services.
As of September 30, 2020 and December 31, 2019 there was $379 and $831, respectively, of deferred costs.
DepositsDeposits
As of September 30, 2020 and December 31, 2019, $941 and $1,099, respectively, of deposits made by the Company with certain service providers that are to be applied to future payments due under the service agreements or returned to the Company if not utilized, were recorded in the condensed consolidated balance sheets.
WarrantsWarrants
On January 1, 2019, the Company adopted ASU No. 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480), and Derivatives and Hedging (Topic 815) (“ASU 2017-11”), which changes the classification analysis of certain equity-linked financial instruments (or embedded features) with down round features. The amendments require entities that present earnings per share (“EPS”) in accordance with Topic 260 to recognize the effect of the down round feature when triggered with the effect treated as a dividend and as a reduction of income available to common stockholders in basic EPS.
The Company concluded that the common stock warrants (the “2017 Warrants”) issued in connection with the private placement of common stock completed in November 2017 (the “November 2017 Private Placement”), qualify for equity classification under ASU 2017-11. The adoption guidance of ASU 2017-11 provides for a modified retrospective adoption. The Company applied the guidance retrospectively to the 2017 Warrants by means of a cumulative-effect adjustment to its statement of financial position as of the beginning of the interim and annual period beginning January 1, 2019. The Company performed a final remeasurement of the warrant liability as of January 1, 2019 and reclassified $3,448 from warrant liability to equity.
The Company will recognize on a prospective basis the value of the effect of the down round feature in the 2017 Warrants when it is triggered (i.e., when the exercise price is adjusted downward). This value is measured as the difference between (1) the financial instrument’s fair value (without the down round feature) using the pre-trigger exercise price and (2) the financial instrument’s fair value (with the down round feature) using the reduced exercise price. The value of the effect of the down round feature will be treated as a dividend and a reduction to income available to common stockholders in the basic EPS calculation. In connection with the public offering, completed in February 2019 (the “2019 Public Offering”), when the 2017 Warrants were repriced from $6.085 to $1.75 as a result of a down round, the Company recorded a dividend of $359 during the nine months ended September 30, 2019. In connection with the private placement of common stock completed in January 2020 (the “January 2020 Private Placement”), when the 2017 Warrants were repriced from $1.75 to $1.055 as a result of a down round, the Company recorded a dividend of $303 during the nine months ended September 30, 2020.
Fair Value of Financial InstrumentsFair Value of Financial Instruments
Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable:
·
Level 1—Quoted prices in active markets for identical assets or liabilities.
·
Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data.
·
Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.
During the periods presented, the Company has not changed the manner in which it values assets and liabilities that are measured at fair value using Level 3 inputs. There were no transfers within the hierarchy during the three and nine months ended September 30, 2020 or the year ended December 31, 2019.
A summary of the assets and liabilities carried at fair value in accordance with the hierarchy defined above is as follows (in thousands):
Total
Level 1
Level 2
Level 3
September 30, 2020
Assets:
Cash equivalents
$
57,975
$
57,975
$

$

Total assets
$
57,975
$
57,975
$

$

December 31, 2019
Assets:
Cash equivalents
$
3,891
$
3,891
$

$

Total assets
$
3,891
$
3,891
$

$

Cash equivalents of $57,975 and $3,891 as of September 30, 2020 and December 31, 2019, respectively, consisted of overnight investments and money market funds and are classified within Level 1 of the fair value hierarchy because they are valued using quoted market prices in active markets.
The carrying value of the research and development incentive receivable, accounts payable and accrued liabilities approximate their fair value due to the short-term nature of these assets and liabilities.
LeasesLeases
In February 2016, the Financial Accounting Standards Board, or FASB, issued ASU 2016-02, Leases, or ASU 2016-02, to enhance the transparency and comparability of financial reporting related to leasing arrangements. The Company adopted ASU 2016-02 on January 1, 2019, or the effective date, and used the effective date as its date of initial application.
At the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the unique facts and circumstances present. Most leases with a term greater than one year are recognized on the balance sheet as right-of-use assets, lease liabilities and, if applicable, long-term lease liabilities. The Company has elected not to recognize on the balance sheet leases with terms of one year or less. Operating lease liabilities and their corresponding right-of-use assets are recorded based on the present value of lease payments over the expected remaining lease term. The Company has determined that the rate implicit in the lease is not determinable and the Company does not have borrowings with similar terms and collateral. Therefore, the Company considered a variety of factors, including observable debt yields from comparable companies and the volatility in the debt market for securities with similar terms, in determining that 8% was reasonable to use as the incremental borrowing rate for purposes of the calculation of lease liabilities.
In accordance with the guidance in ASU 2016-02, components of a lease should be split into three categories: lease components (e.g. land, building, etc.), non-lease components (e.g. common area maintenance, maintenance, consumables, etc.), and non-components (e.g. property taxes, insurance, etc.). Then the fixed and in-substance fixed contract consideration (including any related to non-components) must be allocated based on fair values to the lease components and non-lease components.
Although separation of lease and non-lease components is required, certain practical expedients are available. Entities may elect the practical expedient to not separate lease and non-lease components. Rather, they would account for each lease component and the related non-lease component together as a single component. The Company has elected to account for the lease and non-lease components of each of its operating leases as a single lease component and allocate all of the contract consideration to the lease component only. The lease component results in an operating right-of-use asset being recorded on the consolidated balance sheets and amortized such that lease expense is recorded on a straight line basis over the term of the lease.
Revenue RecognitionRevenue Recognition
The Company records revenue in accordance with Accounting Standards Codification, or ASC, Topic 606, Revenue From Contracts with Customers. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Under Topic 606, an entity recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that an entity determines are within the scope of Topic 606, the entity performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. The Company only applies the five step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied.
License revenueLicense revenue. The Company’s performance obligations under its license agreements may include providing intellectual property licenses, performing technology transfer, performing research and development consulting services and notifying the customer of any enhancements to licensed technology or new technology that it discovers, among others. The Company determined that its performance obligations under its license agreements as evaluated at contract inception were not distinct and represented a single performance obligation. Upfront payments are amortized to revenue on a straight-line basis over the performance period. Upfront payment contract liabilities resulting from the Company’s license agreements do not represent a financing component as the payment is not financing the transfer of goods or services, and the technology underlying the licenses granted reflects research and development expenses already incurred by the Company. Generally, all amounts received or due other than sales-based milestones and royalties are classified as license revenues. Sales-based milestones and royalties under the Company’s license agreements will be recognized as royalty revenue in the period the related sale occurred. The Company generally invoices its licensees upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of the culmination of the earnings process and is recognized as revenue in future periods as performance obligations are satisfied. Deferred revenue expected to be recognized within the next twelve months is classified as a current liability.
Research and Development ServicesResearch and Development Services. The promises under the Company's license agreements may include research and development services to be performed by the Company on behalf of the customer. Payments or reimbursements resulting from the Company's research and development efforts are recognized as the services are performed and presented on a gross basis because the Company is the principal for such efforts.
Customer OptionsCustomer Options. If an arrangement is determined to contain customer options that allow the customer to acquire additional goods or services, the goods and services underlying the customer options that are not determined to be material rights are not considered to be performance obligations at the outset of the arrangement, as they are contingent upon option exercise. The Company evaluates the customer options for material rights, or options to acquire additional goods or services for free or at a discount. If the customer options are determined to represent a material right, the material right is recognized as a separate performance obligation at the outset of the arrangement. The Company allocates the transaction price to material rights based on the relative standalone selling price, which is determined based on the identified discount and the probability that the customer will exercise the option. Amounts allocated to a material right are not recognized as revenue until (1) the option is exercised and the additional goods or services are transferred or (2) the option expires.
Milestone PaymentsMilestone Payments. At the inception of each arrangement that includes research or development milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be overcome to achieve the particular milestone in making this assessment. There is considerable judgment involved in determining whether it is probable that a significant revenue reversal would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment.
RoyaltiesRoyalties . For arrangements that include sales-based royalties, including milestone payments upon first commercial sales and milestone payments based on a level of sales, which are the result of a customer-vendor relationship and for which the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied or partially satisfied. To date, the Company has not recognized any royalty revenue resulting from any of its licensing arrangements.
Collaborative ArrangementsCollaborative Arrangements
The Company analyzes its collaboration arrangements to assess whether such arrangements involve joint operating activities performed by parties that are both active participants in the activities and exposed to significant risks and rewards dependent on the commercial success of such activities and therefore within the scope of ASC Topic 808, Collaborative Arrangements (ASC 808). This assessment is performed throughout the life of the arrangement based on changes in the responsibilities of all parties in the arrangement. For collaboration arrangements within the scope of ASC 808 that contain multiple elements, the Company first determines which elements of the collaboration are deemed to be within the scope of ASC 808 and which elements of the collaboration are more reflective of a vendor-customer relationship and therefore within the scope of ASC 606. For elements of collaboration arrangements that are accounted for pursuant to ASC 808, an appropriate recognition method is determined and applied consistently, generally by analogy to ASC 606. Amounts that are owed to collaboration partners are recognized as an offset to collaboration revenues as such amounts are incurred by the collaboration partner. Where amounts owed to a collaboration partner exceed the Company's collaboration revenues in each quarterly period, such amounts are classified as research and development expense. Reimbursements from and payments to the customer that are the result of a collaborative relationship with a partner, instead of a customer relationship, such as co-development activities, are recorded as a reduction to research and development expense. For those elements of the arrangement that are accounted for pursuant to ASC 606, the Company applies the five-step model described above under ASC 606.
See Note 3 for a complete discussion of the revenue recognition for the Company's license agreement.
Net Loss per ShareNet Loss per Share
Basic net loss per share is computed using the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed using the weighted average number of common shares outstanding during the period and, if dilutive, the weighted average number of potential shares of common stock, including the assumed exercise of stock options and warrants.
Subsequent EventsSubsequent Events
The Company considers events or transactions that occur after the balance sheet date but prior to the issuance of the financial statements to provide additional evidence for certain estimates or to identify matters that require additional disclosure. Subsequent events have been evaluated as required.
Recent Accounting PronouncementsRecent Accounting Pronouncements
From time to time, new accounting pronouncements are issued by the FASB, and are early adopted by the Company or adopted as of the specified effective date.
In November 2018, the FASB issued “ASU 2018-18, Clarifying the Interaction between Topic 808 and Topic 606.” The objective of the standard is to clarify the interaction between ASC Topic 808--Collaborative Arrangements and ASC Topic 606--Revenue from Contracts with Customers. Currently, ASC Topic 808 does not provide comprehensive recognition or measurement guidance for collaborative arrangements, and the accounting for those arrangements is often based on an analogy to other accounting literature or an accounting policy election. Similarly, aspects of ASC Topic 606 have resulted in uncertainty in practice about the effect of the revenue standard on the accounting for collaborative arrangements. The standard became effective for us beginning on January 1, 2020 and the adoption of this ASU did not have a material impact on our financial condition, results of operations, cash flows, and financial statement disclosures.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)9 Months Ended
Sep. 30, 2020
Summary of Significant Accounting Policies
Schedule of change in the research and development incentive receivableThe following table shows the change in the research and development incentive receivable from December 31, 2018 to September 30, 2020 (in thousands):
Balance at December 31, 2018
$
836
Australian research and development incentive income, net
132
Cash received for 2018 eligible expenses
(757)
Foreign currency translation
(26)
Balance at December 31, 2019
185
Australian research and development incentive income, net
343
Cash received for 2019 eligible expenses
(331)
Foreign currency translation
12
Balance at September 30, 2020
$
209
Summary of assets and liabilities carried at fair value in accordance with the hierarchyA summary of the assets and liabilities carried at fair value in accordance with the hierarchy defined above is as follows (in thousands):
Total
Level 1
Level 2
Level 3
September 30, 2020
Assets:
Cash equivalents
$
57,975
$
57,975
$

$

Total assets
$
57,975
$
57,975
$

$

December 31, 2019
Assets:
Cash equivalents
$
3,891
$
3,891
$

$

Total assets
$
3,891
$
3,891
$

$

BeiGene Exclusive Option and _2

BeiGene Exclusive Option and License Agreement (Tables)9 Months Ended
Sep. 30, 2020
BeiGene Exclusive Option and License Agreement
Summary of activity in Company's contract liabilitiesThe following table presents a summary of the activity in the Company's contract liabilities, related to the upfront cash payment received of $3,000, during the nine months ended September 30, 2020 (in thousands):
Balance at
Balance at
January 1,2020
Additions
Deductions
September 30, 2020
Contract liabilities
Deferred revenue - current
$

$
1,500
$

$
1,500
Deferred revenue - non current

1,500
(1,125)
375
Total contract liabilities
$

$
3,000
$
(1,125)
$
1,875

Accrued Expenses (Tables)

Accrued Expenses (Tables)9 Months Ended
Sep. 30, 2020
Accrued Expenses
Schedule of accrued expensesSeptember 30,
December 31,
2020
2019
Clinical trials
$
1,049
$
1,828
Professional fees
191
609
Payroll and related expenses
1,030
1,004
Accrued expenses
$
2,270
$
3,441

Leases (Tables)

Leases (Tables)9 Months Ended
Sep. 30, 2020
Leases
Schedule of future lease paymentsFuture Operating Lease Payments
2020
$
107
2021
434
2022
146
Total Lease Payments
687
Less: imputed interest
(39)
Total operating lease liabilities
$
648

Warrants (Tables)

Warrants (Tables)9 Months Ended
Sep. 30, 2020
Warrants
Schedule of warrantsSeptember 30, 2020
Date
Number of Shares
Exercisable
Issuable
Exercise Price
1/23/2017
54,516
$
11/14/2017
2,549,840
$
1.055
2/5/2019
7,491,442
$
1.95
3/5/2020
14,413,902
$
0.001
3/5/2020
25,945,035
$
2.11
6/22/2020
2,250,000
$
0.001
52,704,735

Equity Incentive Plans (Tables)

Equity Incentive Plans (Tables)9 Months Ended
Sep. 30, 2020
Equity Incentive Plans
Summary of stock option activity under the Equity PlansWeighted
Average
Weighted
Aggregate
Exercise Price
Average Remaining
Intrinsic
Options
Per Share
Life in Years
Value
Outstanding at December 31, 2019
4,024,566
$
7.48
7.98
$
2
Granted
2,547,500
$
2.12
Exercised
(32,778)
$
1.53
Forfeited
(260,435)
$
6.95
Outstanding at September 30, 2020
6,278,853
$
5.35
$
1,082
Options exercisable at September 30, 2020
3,113,663
$
8.45
$
359
Options vested and expected to vest at September 30, 2020
6,278,853
$
5.35
$
1,082
Schedule of assumptions used to determine grant-date fair value of stock optionsNine Months
Year Ended
Ended September 30,
December 31,
2020
2019
Expected volatility
66.94
%
66.94
%
Weighted average risk-free interest rate
0.66
%
%
Expected dividend yield
0.00
%
0.00
%
Expected term (in years)
6.77
Schedule of stock-based compensation expense related to issuance of stock option awards recognized in condensed consolidated statements of operationsThree Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Research and development
$
282
$
181
$
720
$
536
General and administrative
309
769
967
2,260
Total
$
591
$
950
$
1,687
$
2,796
Summary of outstanding RSU under the 2016 PlanWeighted
Average
Number of
Grant Date
Shares
Fair Value
Outstanding at December 31, 2019
90,500
$
1.74
Awarded
753,106
$
1.49
Settled in cash
(90,500)
$
1.74
Outstanding at June 30, 2020
753,106
$
1.49

Net Loss Per Share (Tables)

Net Loss Per Share (Tables)9 Months Ended
Sep. 30, 2020
Net Loss Per Share
Schedule of basic and diluted net loss per shareThree Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Numerator:
Net loss
$
(7,057)
$
(7,935)
$
(20,804)
$
(24,904)
Dividend attributable to down round feature of warrants


(303)
(359)
Dividend attributable to Series A & B convertible preferred stock


(372)

Series A & B convertible preferred stock - beneficial conversion feature


(9,399)

Net loss attributable to common stockholders for basic and diluted loss per share
$
(7,057)
$
(7,935)
$
(30,878)
$
(25,263)
Denominator:
Weighted average number of common shares outstanding – basic and diluted
76,321,644
23,923,196
53,548,902
22,039,386
Net loss per share attributable to common stockholders – basic and diluted
$
(0.09)
$
(0.33)
$
(0.58)
$
(1.15)
Schedule of potentially anti-dilutive securities excluded from calculation of diluted net loss per shareThree Months Ended September 30,
Nine Months Ended September 30,
2020
2019
2020
2019
Restricted stock units to purchase common stock
753,106

753,106

Options to purchase common stock
6,278,853
4,019,566
6,278,853
4,019,566
Warrants to purchase common stock
36,040,833
10,369,752
36,040,833
10,369,752
43,072,792
14,389,318
43,072,792
14,389,318

Nature of Business, Basis of _2

Nature of Business, Basis of Presentation and Liquidity - Liquidity (Details) - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019
Liquidity
Accumulated deficit $ 216,275 $ 216,275 $ 195,168
Net loss7,057 $ 7,935 20,804 $ 24,904
Net cash used in operating activities(19,969) $ (21,008)
Cash and cash equivalents $ 57,975 $ 57,975 $ 3,891
Minimum period to fund Operating expense12 months

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Significant Accounting Policies (Details) - USD ($) $ / shares in Units, $ in ThousandsJan. 01, 2019Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019Mar. 05, 2020Jan. 31, 2019
Research and development incentive income and receivable
Research and development expenses reimbursed (as a percent)43.50%43.50%43.50%
Adjustment to increase Australian research and development incentive income $ 150
Research and development incentive income and receivable
Balance at the beginning of the period $ 836 $ 185 $ 836 $ 836
Australian research and development incentive income, net228 $ (7)343 129 132
Cash received for eligible expenses(331)(757)
Foreign currency translation12 (26)
Balance at the end of the period209 209 185
Deferred Offering Costs
Deferred Offering Costs Noncurrent379 379 831
Other Assets
Deposits with service providers that are to be applied to future payments $ 941 941 $ 1,099
Warrant liability reclassified to equity $ 3,448 3,448
Dividend attributable to down round feature of warrants $ 303 359
Incremental borrowing rate8.00%8.00%
2019 Public Offering
Other Assets
Exercise price of warrant $ 1.75 $ 1.75 $ 6.085
Dividend attributable to down round feature of warrants $ 359
January 2020 Private Placement
Other Assets
Exercise price of warrant $ 1.055 $ 1.055 $ 2.11 $ 1.75
Dividend attributable to down round feature of warrants $ 303

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Fair Value of Financial Instruments (Details) - USD ($) $ in ThousandsSep. 30, 2020Dec. 31, 2019
Assets:
Cash equivalents $ 57,975 $ 3,891
Total assets57,975 3,891
Level 1
Assets:
Cash equivalents57,975 3,891
Total assets $ 57,975 $ 3,891

BeiGene Exclusive Option and _3

BeiGene Exclusive Option and License Agreement - Additional Information (Details) - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2020Jan. 03, 2020
BeiGene Exclusive Option and License Agreement
Up-front fee $ 3,000
Contract acquisition costs $ 270 270
Amortization expense34 101
Deferred Costs169 169
Exclusive Option and License Agreement
BeiGene Exclusive Option and License Agreement
Upfront cash payment3,000 3,000 $ 3,000
Future option exercise and milestone payments, maximum $ 132,000
License
BeiGene Exclusive Option and License Agreement
Revenue recognized375 1,125
Royalty
BeiGene Exclusive Option and License Agreement
Revenue recognized $ 0 $ 0

BeiGene Exclusive Option and _4

BeiGene Exclusive Option and License Agreement - Contract Liabilities (Details) $ in Thousands9 Months Ended
Sep. 30, 2020USD ($)
Deferred revenue - current
Additions $ 1,500
Balance at March 31, 20201,500
Deferred revenue - non current
Additions1,500
Deductions(1,125)
Balance at March 31, 2020375
Total contract liabilities
Additions3,000
Deductions(1,125)
Contract liabilities $ 1,875

Accrued Expenses (Details)

Accrued Expenses (Details) - USD ($) $ in ThousandsSep. 30, 2020Dec. 31, 2019
Accrued Expenses
Clinical trials $ 1,049 $ 1,828
Professional fees191 609
Payroll and related expenses1,030 1,004
Accrued expenses $ 2,270 $ 3,441

Leases (Details)

Leases (Details) - USD ($) $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019Jan. 01, 2019
Right of use assets, net $ 620 $ 620 $ 1,026
Lease liability648 648
Rent expense $ 105 $ 211 $ 445 $ 629
Restatement Adjustment | Accounting Standards Update 2016-02 [Member]
Right of use assets, net $ 1,720
Lease liability1,720
Reclassification of rent liability against right-of-use asset $ 35

Leases - Future minimum lease p

Leases - Future minimum lease payments (Details) $ in ThousandsSep. 30, 2020USD ($)
Leases
2020 $ 107
2021434
2022146
Total Lease Payments687
Less: Imputed Interest(39)
Total operating lease liabilities $ 648

Warrants - (Details)

Warrants - (Details) - USD ($) $ / shares in Units, $ in ThousandsJun. 22, 2020Mar. 05, 2020Jan. 03, 2020Feb. 05, 2019Jan. 01, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019
Warrants
Number of Shares Issuable52,704,735
Warrant liability reclassified to additional paid in capital $ 3,448
Warrant, Down Round Feature, (Increase) Decrease in Equity, Amount $ 303 $ 359
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)7,557,142
Common stock issued7,557,142
Series A Convertible Preferred Stock
Warrants
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)1,421,801
Common stock issued1,421,801
Series B Convertible Preferred Stock
Warrants
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)1,137,442
Common stock issued1,137,442
2017 Warrants
Warrants
Exercise price of warrant $ 6.085 $ 1.055 $ 1.75
Class of Warrant or Right, Exercised $ 220
Number of warrants or rights exercised.208,254,000
2019 Warrants
Warrants
Number of Shares Issuable7,557,142
Exercise price of warrant $ 1.95
Class of Warrant or Right, Exercised $ 128
Number of warrants or rights exercised.65,700,000
January 2020 Warrants | Series A Convertible Preferred Stock
Warrants
Exercise price of warrant $ 0.001
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)1,421,801
Purchase price $ 10.54
Warrant to purchase shares of common stock14,413,902
Common stock issued1,421,801
January 2020 Warrants | Series B Convertible Preferred Stock
Warrants
Exercise price of warrant $ 2.11
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)1,137,442
Purchase price $ 10.55
Conversion of Stock, Shares Issued11,531,133
Common stock issued1,137,442
June 2020 Warrants
Warrants
Exercise price of warrant $ 0.001
Warrant to purchase shares of common stock2,250,000
June 2020 Warrants | Common Stock
Warrants
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)20,250,000
Purchase price $ 2
Common stock issued20,250,000
1/23/2017
Warrants
Number of Shares Issuable54,516
Exercise price of warrant $ 0.01
11/14/2017
Warrants
Number of Shares Issuable2,549,840
Exercise price of warrant $ 1.055
2/5/2019
Warrants
Number of Shares Issuable7,491,442
Exercise price of warrant $ 1.95
3/5/2020
Warrants
Number of Shares Issuable14,413,902
Exercise price of warrant $ 0.001
3/5/2020
Warrants
Number of Shares Issuable25,945,035
Exercise price of warrant $ 2.11
6/22/2020
Warrants
Number of Shares Issuable2,250,000
Exercise price of warrant $ 0.001
Common Stock | June 2020 Warrants
Warrants
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares)20,250,000
Common stock issued20,250,000

Common stock - Public Offering

Common stock - Public Offering of Common Stock (Details) $ / shares in Units, $ in ThousandsJun. 25, 2020USD ($)sharesJun. 22, 2020$ / sharessharesJul. 11, 2019USD ($)$ / sharessharesJul. 10, 2019USD ($)sharesFeb. 05, 2019$ / sharessharesSep. 07, 2018USD ($)Sep. 30, 2020sharesMar. 31, 2019USD ($)Sep. 30, 2020USD ($)itemsharesSep. 30, 2019USD ($)Dec. 31, 2019USD ($)shares
Common stock issued7,557,142
Price per share (in dollars per share) | $ / shares $ 1.75
Proceeds from the issuance of common stock | $ $ 12,122
Proceeds From Issuance Of Common Stock Net Of Issuance Costs | $ $ 999
Number of Vote on Common Shares | item1
Dividends, Common Stock | $ $ 0
June 2020 Warrants
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares $ 0.001
Exercise price of warrant | $ / shares $ 0.001
Warrant to purchase shares of common stock2,250,000
February 2019 [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares1.95
Exercise price of warrant | $ / shares $ 1.95
Common Stock | June 2020 Warrants
Common stock issued20,250,000
Issue price | $ / shares $ 2
Net proceeds from issuance of common stock | $ $ 48,276
Distribution Agreement [Member]
Common stock issued0 1,033,147
Commons Stock Value Maximum Right To Sell | $ $ 30,000
Proceeds From Issuance Of Common Stock From Atm Sales | $ $ 1,923
Lincoln Park Purchase Agreements [Member]
Common stock issued571,429 0 0
Price per share (in dollars per share) | $ / shares $ 1.75
Commons Stock Value Maximum Right To Sell | $ $ 20,000
Stock Issued During Period, Shares, Issued for Services330,000
Proceeds From Issuance Of Common Stock Net Of Issuance Costs | $ $ 1,000 $ 0
Underwriters' exercise
Shares issued985,714
Underwriters' exercise | Common Stock | June 2020 Warrants
Common stock issued3,375,000
Common Stock | June 2020 Warrants
Common stock issued20,250,000

Common Stock - Private Placemen

Common Stock - Private Placement of Common Stock (Details) - USD ($) $ / shares in Units, $ in ThousandsJan. 03, 2020Feb. 05, 2019Sep. 30, 2020Mar. 05, 2020Dec. 31, 2019Jan. 31, 2019
Private Placement of Common Stock
Common stock issued7,557,142
Price per share (in dollars per share) $ 1.75
Common Stock, Par or Stated Value Per Share $ 0.001 $ 0.001
January 2020 Private Placement
Private Placement of Common Stock
Exercise price of warrant $ 1.055 $ 2.11 $ 1.75
Fixed cumulative percentage per annum8.00%
Cumulative Dividends $ 372
Series A Preferred | January 2020 Private Placement
Private Placement of Common Stock
Common stock issued1,421,801
Price per share (in dollars per share) $ 10.54
Net proceeds from issuance of stock in private placement $ 25,322
Convertible Preferred Stock, Shares Issued upon Conversion14,413,902
Common Stock, Par or Stated Value Per Share $ 0.001
Value of beneficial conversion features $ 5,226
Series B Preferred | January 2020 Private Placement
Private Placement of Common Stock
Common stock issued1,137,442
Price per share (in dollars per share) $ 10.55
Convertible Preferred Stock, Shares Issued upon Conversion11,531,133
Common Stock, Par or Stated Value Per Share $ 0.001
Value of beneficial conversion features $ 4,173

Equity Incentive Plans - Equity

Equity Incentive Plans - Equity Incentive Plans (Details) - USD ($) $ / shares in Units, $ in ThousandsJan. 20, 2017Oct. 31, 2019Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019
Stock-Based Compensation
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross2,547,500
Allocated Share-based Compensation Expense $ 591 $ 950 $ 1,687 $ 2,796
Restricted stock liability66 66 $ 159
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized $ 4,453 $ 4,453
Maximum
Stock-Based Compensation
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period4 years
2016 Plan
Stock-Based Compensation
Number of options or stock awards available for grant under the Plan455,144 455,144
Annual increase in authorized shares (as a percent)4.00%
Common Stock | 2016 Plan
Stock-Based Compensation
Additional shares issuable3,000,000
Restricted Stock Units (RSUs)
Stock-Based Compensation
Restricted stock liability $ 66 $ 66 $ 159
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value1,112
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount $ 884 $ 884
Restricted Stock Units (RSUs) | Executive Officer [Member]
Stock-Based Compensation
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period660,606
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period3 years
Allocated Share-based Compensation Expense $ 170
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsSettledInCash90,500
Restricted Stock Units (RSUs) | 2016 Plan
Stock-Based Compensation
Number of options issued under the plan92,500 181,000
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period753,106
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsSettledInCash(90,500)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value $ 1.49

Equity Incentive Plans - Stock

Equity Incentive Plans - Stock options (Details) - USD ($) $ / shares in Units, $ in Thousands1 Months Ended3 Months Ended9 Months Ended12 Months Ended
Oct. 31, 2019Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019Dec. 31, 2019Sep. 30, 2020Dec. 31, 2019
Options
Outstanding balance at the beginning of the period (in shares)4,024,566
Granted (in shares)2,547,500
Exercised (in shares)(32,778)
Forfeited (in shares)(260,435)
Outstanding balance at the end of the period (in shares)6,278,853 6,278,853 4,024,566
Options exercisable at the end of the period (in shares)3,113,663
Options vested and expected to vest at end of period (in shares)6,278,853
Weighted Average Exercise Price Per Share
Outstanding balance at the beginning of the period (in dollars per share) $ 7.48
Granted (in dollars per share)2.12
Exercised (in dollars per share)1.53
Forfeited (in dollars per share)6.95
Outstanding balance at the end of the period (in dollars per share) $ 5.35 $ 5.35 $ 7.48
Exercisable at the end of the period (in dollars per share) $ 8.45
Options vested and expected to vest at end of the period (in dollars per share) $ 5.35
Weighted Average Remaining Life in Years
Outstanding balance8 years 2 months 5 days7 years 11 months 23 days
Options exercisable at end of period7 years 1 month 13 days
Options vested and expected to vest at end of the period8 years 2 months 5 days
Aggregate Intrinsic Value
Outstanding balance $ 1,082 $ 2
Options exercisable at the end of the period359
Options vested and expected to vest at end of the period1,082
Stock-based compensation expense $ 591 $ 950 $ 1,687 $ 2,796
Assumptions used to determine grant-date fair value
Expected Volatility66.94%66.94%
Weighted average risk-free interest rate0.66%2.07%
Expected dividend yield0.00%0.00%
Expected term (in years)6 years 10 months 6 days6 years 9 months 7 days
Expiration period10 years
Compensation cost related to the non-vested awards not yet recognized $ 4,453
Weighted average period for recognition of compensation cost2 years 2 months 16 days
Research and development
Aggregate Intrinsic Value
Stock-based compensation expense282 181 $ 720 536
General and administrative
Aggregate Intrinsic Value
Stock-based compensation expense $ 309 $ 769 $ 967 $ 2,260
Minimum
Assumptions used to determine grant-date fair value
Vesting period3 years
Maximum
Assumptions used to determine grant-date fair value
Vesting period4 years
Restricted Stock Units (RSUs)
Assumptions used to determine grant-date fair value
Weighted average period for recognition of compensation cost2 years 2 months 1 day
Restricted Stock Units (RSUs) | Executive Officer [Member]
Aggregate Intrinsic Value
Stock-based compensation expense $ 170
Assumptions used to determine grant-date fair value
Vesting period3 years
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Awarded660,606
Settled in cash90,500
Restricted Stock Units (RSUs) | 2016 Plan
Assumptions used to determine grant-date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value $ 1.49 $ 1.49 $ 1.74 $ 1.49 $ 1.74
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Outstanding at the beginning90,500
Awarded753,106
Settled in cash(90,500)
Outstanding at the end753,106 753,106 90,500
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Outstanding at beginning( in dollars per share) $ 1.74
Awarded (in dollars per share)1.49
Settled in cash(in dollars per share)1.74
Outstanding at end(in dollars per share) $ 1.49 $ 1.49 $ 1.74

Net Loss Per Share - Basic and

Net Loss Per Share - Basic and Diluted (Details) - USD ($) $ / shares in Units, $ in Thousands3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019
Numerator:
Net loss $ (7,057) $ (7,935) $ (20,804) $ (24,904)
Dividend attributable to down round feature of warrants(303)(359)
Dividend attributable to Series A & B convertible preferred stock(372)
Series A & B convertible preferred stock - beneficial conversion feature(9,399)
Net loss attributable to common stockholders for basic and diluted loss per share $ (7,057) $ (7,935) $ (30,878) $ (25,263)
Denominator:
Weighted average number of common shares outstanding - basic and diluted (in shares)76,321,644 23,923,196 53,548,902 22,039,386
Net loss per share attributable to common stockholders - basic and diluted (in dollars per share) $ (0.09) $ (0.33) $ (0.58) $ (1.15)
Exercise of the pre-funded warrants16,663,902

Net Loss Per Share - Antidiluti

Net Loss Per Share - Antidilutive (Details) - shares3 Months Ended9 Months Ended
Sep. 30, 2020Sep. 30, 2019Sep. 30, 2020Sep. 30, 2019
Securities excluded from computation of diluted net loss per share
Anti-dilutive securities excluded from calculation of diluted net loss per share43,072,792 14,389,318 43,072,792 14,389,318
Restricted Stock Units (RSUs)
Securities excluded from computation of diluted net loss per share
Anti-dilutive securities excluded from calculation of diluted net loss per share753,106 753,106
Options to purchase common stock
Securities excluded from computation of diluted net loss per share
Anti-dilutive securities excluded from calculation of diluted net loss per share6,278,853 4,019,566 6,278,853 4,019,566
Warrants to purchase common stock
Securities excluded from computation of diluted net loss per share
Anti-dilutive securities excluded from calculation of diluted net loss per share36,040,833 10,369,752 36,040,833 10,369,752

Commitments and Contingencies -

Commitments and Contingencies - Manufacturing, License and Other Agreements (Details) $ in ThousandsSep. 30, 2020USD ($)
Commitments and Contingencies
Manufacturing commitments $ 381
License and service agreements
Commitments and Contingencies
Royalties paid or accrued0
Licensing agreements
Commitments and Contingencies
Royalties paid or accrued $ 0

Commitments and Contingencies_2

Commitments and Contingencies - Legal Proceedings (Details)1 Months Ended
Mar. 31, 2017entity
Commitments and Contingencies
Number filing notice of opposition10