Exhibit 99.2
Company Introduction April 2021
Forward-Looking Statements This presentation contains "forward-looking statements" relating to future events, and AgPlenus (the “Company”) and its parent, Evogene Ltd. (“Evogene”), may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting us that are considered “forward-looking statements” as defined in the U.S. Private Securities Litigation Reform Act of 1995 (the “PSLRA”) and other securities laws. Such forward-looking statements may be identified by the use of such words as “believe”, “expect”, “anticipate”, “should”, “planned”, “estimated”, “intend” and “potential” or words of similar meaning. We are using forward-looking statements in this presentation when we discuss our value drivers, commercialization efforts and timing, product development and launches, estimated market sizes and milestones, as well as the capabilities of Evogene’s and our technology. Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance or achievements, and trends in the future may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond our control, including, without limitation, those described in greater detail in Evogene's Annual Report on Form 20-F and in other information Evogene files and furnishes with the Israel Securities Authority and the U.S. Securities and Exchange Commission, including those factors under the heading “Risk Factors”. Except as required by applicable securities laws, we disclaim any obligation or commitment to update any information contained in this presentation or to publicly release the results of any revisions to any statements that may be made to reflect future events or developments or changes in expectations, estimates, projections and assumptions.The information contained herein does not constitute a prospectus or other offering document, nor does it constitute or form part of any invitation or offer to sell, or any solicitation of any invitation or offer to purchase or subscribe for, any securities of Evogene or the Company, nor shall the information or any part of it or the fact of its distribution form the basis of, or be relied on in connection with, any action, contract, commitment or relating thereto or to the securities of Evogene or the Company. The trademarks included herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construed as an endorsement of our products or services.
Agenda Company introductionBusiness modelProduct pipelineTechnologyMilestone roadmap 3
We design next-generation, effective, sustainable and safer crop protection products by leveraging predictive biology & chemistry OURVISION 4
Growing market for Crop Protection products with need for innovation 5 Growing market Product introductions lag Source: Facts & Factors No new Mode-of-Action (MoAs) for 3 decadesMajor Ag companies have failed to meet the demand for innovation Number of new active ingredients introduced (decade)
Herbicide resistant weeds have flourished 6 Overuse of existing Modes of Actions (MoAs) has generated selection pressure 263 herbicide-resistant weed species have evolved*Substantial economic cost to farmersIncrease costs and reduce yieldsUnited States: Soybeans: $35/acre additional costs**$2 billion / year increased costs and lost yields*** Glyphosate-resistant Palmer Amaranth Sources * Intl. Herbicide Resistant Weed Database ** AgriBusiness Global, Farm Progress *** Michigan Farm News
Discovery Computational selection of the most promising candidates to initiate the product development process Hit Discovery Hit to Lead Lead Optimization AgPlenus’ target-based technology addresses the challenges OptimizationComputationally driven solution addressing optimization development challenges for the selected candidates, supporting the way to successful commercialization. 7 Target Identification Powered by: AgPlenus’ Technology
Experienced board of directors Robert A. WoodsMarrone Bio Innovations, Inc., ChairmanBioenterprise capital private equityPreviously, Syngenta, President USA Eli AssrafGalam Ltd., DirectorPreviously, Makhteshim Agan (Adama), CFO & COOStrauss Group, CFO Ofer HavivChairman of the board Evogene, President & CEO Innovative & experienced management team Eran Kosover Previously AgPlenus Ltd., CEOEvogene EVP & GM Crop Protection, Evogene VP of collaborations, Atera Networks Mirit RamDirector of Project Management Previous positions: Evogene, PMFMC, PMHP Boaz InbalVP R&D Previous positions: Epix pharmaceuticals, DirectorInsilicore, CEOPromining therapeutics, CTO Douglas A. Eisner CEO Previous positions: AgroSpheres, Inc., CEOGrassRoots Biotechnology, Inc., Co-founder and COO 8
Agenda Company introductionBusiness modelProduct pipelineTechnologyMilestone roadmap 9
Product development stages 10 Discovery Lead Optimization Target Hit Lead Commercial-level efficacy (field tests)Weed spectrumResistance-breakingTarget validatedIP filedStrong business case Commercial-level efficacy (multiple field trials)Formulation fixedInitial safety studiesCOGS (process chemistry)IP prosecution Greenhouse evidence for efficacyBinding pose to target understoodInitial business case Essentiality in target pestsAmenable to functional modification by a chemical compoundNovelty Registration (dossier)Manufacturing scale-upMarketing launch Commercial product Partners & Licensees Optimized Lead Continued Dev. & Registration
Business model – value creation through product development process 11 As candidates move further through our pipeline, we expect to receive higher fees from collaborators and licensees. Value Stage Candidate Target Hit Lead Optimized Lead Commercial product
Crop protection industry 12 Dominated by four Major ag-chemical companies70%* of ag-chemical crop protection marketPace of innovation and new product introductions have slowedLooking to smaller, ag-tech companies to develop new small-molecule candidatesAgPlenus is leading the integration of computational technology to discover small moleculesFocusing on developing products with new MoAs * Canadian Council on Food Safety and Health
Business model & potential revenue stream Discovery Lead Optimization Dev. & Registration Partners & Licensees Sales We typically provide our collaborators exclusive licenses with respect to a specified discovery, product type or market areaResearch & development fees typically cover the costs we incur during the discovery and optimization activity When our product candidates reach significant development milestones in the product development pipelines of our collaborators Royalty payments from sales of commercial products developed under the collaboration License fees & R&D fees Milestone payments Royalties
Corteva collaboration Develop new MoA herbicides to target resistant weeds Entered March 2020AgPlenus will discover and optimize herbicide candidatesCorteva will conduct testing and product developmentLicense to CortevaCorteva has exclusive license to products of collaborationAgPlenus receives research fees, milestones and royalties upon commercializationGoal for 2021 Advance development of collaboration compounds 14
Agenda Company introductionBusiness modelProduct pipelineTechnologyMilestone roadmap 15
Products under development 16 Herbicides:Novel MoA (Mode-of-Action) herbicidesOptimize existing herbicides to overcome resistanceHigh value crops – Corn, Soybean, Cereals, Rice, Cotton, Canola …By 2022, addressable market expected: $34B Insecticides:Novel SoA (Site-of-Action)By 2022, addressable market expected : $19B Sources: Research and Markets, Markets and Markets
Herbicides APTH 1 APTH 13 APTH 6 APTH 3 – S1 APTH 5, 8, 14 & 15 Insecticides APTI 2,3 AG 15306 AG 15324 AG 15325 AG 8146 X 4 AG 8783 Discovery Lead Optimization Pre-Development Development & Registration APH1 Novel MoA/SoA Target (1) X 2 Lead Hit Opt. Lead Pre Dev. Comp. AgPlenus product pipeline
APH 1 – New MoA herbicide reached Lead stage 18 Broad-spectrum weed control at commercial dosage ratesEffective against resistant weed strains – including Palmer Amaranth Solvent control APH1 (0.5 kg/ha) Glyphosate (0.75 kg/ha) (16DAA) (Rehovot, Israel; Aug. 2020)
APH 1 - a new MoA non-selective herbicide candidate 19 APH 1 displays herbicidal activity on multiple important weed species, both grasses and broad-leaves Relevant target crops – Cereals, Rice, Corn, Soybean, Cotton, Canola, Sugar beetLeading relevant geographies APH 1 target/MoA does not exist in human – high safety potentialMolecule safety predicted using multiple computational tools Molecule and several analogs synthesizedOngoing efforts to reduce production costs Good solubility, APH 1 active in water-based formulationsAPH 1 active both in pre- and post-emergence applications Product Efficacy Market Potential Safety Production Product Application APH 1 active on a new MoA – providing a solution to the rising resistance problem New MoA APH 1Non-selective grass and broadleaf herbicide
New MoA Herbicide active at commercial concentrations 20
APH 1 – Product efficacy 21 Strong activity on a broad panel of target weedsNo weed recovery from herbicide effect Strong activity in pre-application on both grasses and broad leaves LTP single dose (0.75 kg/ha), pre, TP2 (18DAA) APH 1Non-selective grass and broadleaf herbicide Broad activity, pre and post application ~750 gr/Ha ~750 gr/Ha APH 1 APH 1 APH 1 displays herbicidal activity on multiple important weed species, both grasses and broad-leaves Product Efficacy
APH 1 is a new MoA non-selective herbicide candidateKey next milestones 22 2022-2023 APH 1Non-selective grass and broadleaf herbicide Discovery Lead Optimization Target Hit Lead Commercial product Partners & Licensees Optimized Lead Continued Dev. & Registration
Agenda Company introductionBusiness modelProduct pipelineTechnologyMilestone roadmap 23
AgPlenus technology empowered by Evogene’s ChemPass AI 24 Chemistry library Research Development 160,000(random collection, undergo certain filters) 1 Product 1,000,000,000 ~10,000SMART library – enriched for key product attributes 1 Product Discovery Optimization ‘Standard’ crop protection pipeline – sequential screening Target-based product-driven crop protection pipeline Criteria 1 Criteria 2 Criteria 3 Criteria 4 Criteria N Predictive Biology Platform addressing multiple product criteria Delivering needed innovation & sustainabilityIncreased probability of success & reduced cost 100% New & safer MoAs 5% New MoA (estimated) Limited success & constantly increasing costs
Computational prediction of multiple product attributes 25 E-fate* Synthesizability* Absorbance* Mobility Phytotoxicity Metabolism* Safety Target Binding Structure based design Drugability Selectivity Resistance Energy calculation MD simulations Formulation/mixes Toxicity Eco-Toxicity Novelty PhysChem Diversity Efficacy Essentiality * In-process / Planned
From target to an optimized lead 26 PointLeadTM Target discovery & prioritization Hit discovery Hit & Lead optimization Several novel targets identified and successfully validated in-planta Active Hits discovered and successfully validated in-planta Hits optimized to achieve improved efficacy and target-binding
Experimental pipeline up to ‘Lead’ stage 27
Agenda Company introductionBusiness modelProduct pipelineTechnologyMilestone roadmap 28
Expected main near-term value drivers 29 New MoA Herbicide – reach an ‘Optimized Lead’ phase in the herbicide programNew MoA Herbicide – sign a strategic agreement for the development of an ‘Optimized Lead’ compound New MoA Herbicide – reach a herbicide tolerance trait POC for a ‘Lead’ herbicide under developmentNew MoA Herbicide/SoA Insecticide - sign a licensing agreement for a leading candidate 2021 2022
30 We are AgPlenusCreating effective, sustainable and safer crop protection products
THANK YOU