HLA Typing Service Agreement
between
HistoGenetics,LLC.,300 Executive Blvd., Ossining, NY 10562, USA (“HistoGenetics”),
and BriaCell Therapeutics Corp, 820 Heinz Avenue, Berkeley, CA 94710 (“BriaCell”).
HistoGeneticsis an independent private company that specializes in HLA typing by DNAsequencing(SBT).
Subject of theAgreement
Performance of HLA high-resolution typing usingNGS forBriacellby HistoGenetics
1. | Sample Delivery and Duration |
l.1. | BriaCell will ship toHistoGeneticstime to timesamplesfor HLA-A, -B, -C, -DRB1, - DRB345, -DQAl,-DQBl,-DPAl and DPBl typing byNGS(Next Generation Sequencing). |
1.2. | HistoGenetics isstronglycommitted and recognizedasa laboratorywitha high quality level. Therefore HistoGeneticswillbe accredited at ASHIforHLAtypingand PCR-SBT. HistoGeneticswillinform BriaCell immediately iftheASHIaccreditation ofHistoGenetics has expired. |
1.3. | Tum-around timeis18 days. |
2. | Quality Specifications |
2.1. | Typing resolution: HLA-A,-B,-C, -DRBl,-DRB345, -DQAl,-DQBl, -DPAl and DPB1 8x High ResolutiontypingbyPacBio SMRTsequencing. Illumina technology may beusefor confirmationofHomozygous typing. |
2.2. | Typing methodologyand resolutionis8xhigh resolution byNGSincludingwhole gene for classIandexon2to3’UTRforclassILAllfieldsareresolvedwithoutNMDP codes. |
2.3. | HistoGeneticswill updatethe HLA database that is used to analyze the resultsyearlybut when a newvariantisfounditwill compareittothe latestdatabase. |
2.4. | Uponrequest HistoGeneticswillprovidethe rawdata to BriaCellatnocharge. The rawdatawillbe providedas text stringin XML-formataccording to theNMDPstandard.Raw datafor additional ornonNGStypings canbe submittedin differentformats,if thesearepreviouslyagreed onby HistoGeneticsandBriaCell. |
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3. | SampleVolumeand Pricing |
3.1. | Pricing isbasedonabout 50-100samplesper 24 months.Thecostof HLA-A,-B,-C, -DRBl,-DRB345, -DQA I,-DQBl,-DPAl and DPBl 8x high resolutiontypingbyNGSis$250/sample. |
3.2. | HistoGeneticsshallinvoice allcompleted workperformed on a monthly basis. Payment terms is net30daysfromthe invoice date. |
4. | Term and Termination |
4.1. | This Agreement is entered intoeffective,as of June1st,2019fora two yearperiod. |
4.2. | Therightto terminate thisAgreementforgood causeuponwrittennoticewithimmediate effectshallremain unaffected.ThisAgreementmaybe terminated in the eventofbut not limitedto |
4.2.1 | byBriacell in the eventofthesuspension or revocation ofthe ASHIaccreditation of HistoGenetics. | |
4.2.2 | by either party upon insolvencyorbankruptcyoftheotherparty. |
5. | Miscellaneous |
5.1. | HistoGeneticsstoresmaterial for 3 months.The samples willbe destroyed after that period unless instructedotherwiseby the Briacell. |
5.2. | Orders andelectronicresult reporting are processed ascurrently agreed upon. |
5.3. | If processesneedtobe altered bothpartieswillcollaborate to implement necessarychanges. |
5.4. | HistoGeneticswill thereforeinform Briacell in advanceof any plannedmajorchangeinthelegalstructureof HistoGeneticsandespecially inthe structure ofthe top management. |
5.5. | HistoGeneticswill report newalleles of BriaCelldonors to the WHO nomenclaturecommittee.HistoGenetics will alsoprovide BriaCellwith all information thatare necessary for scientificanalysisofnew alleles.Respectiveresultswill bejointly publishedbyBriaCelland HistoGenetics. |
5.6. | This Agreement shallbegovernedbyand construedinaccordance withthe lawsoftheNewYork State, withoutgivingeffectto itschoice of law principles. |
5.7. | Exclusive court of jurisdictionisNewYorkWestchester county. |
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Briacell | HistoGenetics LLC. | |
03 June 2019 | ||
Date, Signature | Date, Signature |
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