Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement on FormS-8 pertaining to the 2018 Equity Incentive Plan of Alpine Immune Sciences, Inc. of our report dated March 28, 2018, with respect to the consolidated financial statements of Alpine Immune Sciences, Inc. included in its Annual Report (Form10-K) for the year ended December 31, 2017, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Seattle, Washington
June 18, 2018