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Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
Cortexyme, Inc.
South San Francisco, California
We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-238851) and Form S-8 (Nos. 333-253743, 333-237199 and 333-231307) of Cortexyme, Inc. of our reports dated March 1, 2022, relating to the consolidated financial statements, and the effectiveness of Cortexyme, Inc.’s internal control over financial reporting, which appear in this Form 10-K.
/s/ BDO USA, LLP
San Jose, California
March 1, 2022