Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2022 | Aug. 08, 2022 | |
Cover [Abstract] | ||
Entity Registrant Name | Spruce Biosciences, Inc. | |
Entity Central Index Key | 0001683553 | |
Document Type | 10-Q | |
Document Period End Date | Jun. 30, 2022 | |
Trading Symbol | SPRB | |
Amendment Flag | false | |
Document Fiscal Year Focus | 2022 | |
Document Fiscal Period Focus | Q2 | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Non-accelerated Filer | |
Entity Common Stock, Shares Outstanding | 23,560,250 | |
Entity Shell Company | false | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Emerging Growth Company | true | |
Entity Ex Transition Period | false | |
Entity Small Business | true | |
Entity File Number | 001-39594 | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 81-2154263 | |
Entity Address, Address Line One | 2001 Junipero Serra Boulevard | |
Entity Address, Address Line Two | Suite 640 | |
Entity Address, City or Town | Daly City | |
Entity Address, State or Province | CA | |
Entity Address, Postal Zip Code | 94014 | |
City Area Code | 415 | |
Local Phone Number | 655-4168 | |
Document Quarterly Report | true | |
Document Transition Report | false | |
Title of 12(b) Security | Common Stock, par value $0.0001 per share | |
Security Exchange Name | NASDAQ |
CONDENSED BALANCE SHEETS (Unaud
CONDENSED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Current assets: | ||
Cash and cash equivalents | $ 47,210 | $ 42,748 |
Short-term investments | 46,085 | 46,221 |
Prepaid expenses | 2,821 | 2,530 |
Other current assets | 390 | 396 |
Total current assets | 96,506 | 91,895 |
Restricted cash | 216 | 216 |
Right-of-use assets, net | 1,314 | 1,479 |
Long-term investments | 5,805 | 32,459 |
Other assets | 674 | 437 |
Total assets | 104,515 | 126,486 |
Current liabilities: | ||
Accounts payable | 1,445 | 2,823 |
Term loan, current portion | 811 | 0 |
Accrued expenses and other current liabilities | 6,953 | 4,613 |
Accrued compensation and benefits | 893 | 1,435 |
Total current liabilities | 10,102 | 8,871 |
Term loan, net of current portion | 4,077 | 4,878 |
Lease liability, net of current portion | 1,098 | 1,293 |
Other liabilities | 117 | 73 |
Total liabilities | 15,394 | 15,115 |
Commitments and contingencies (Note 8) | ||
Stockholders’ equity: | ||
Preferred stock, $0.0001 par value, 10,000,000 shares authorized, no shares issued or outstanding as of June 30, 2022 and December 31, 2021 | 0 | 0 |
Common stock, $0.0001 par value, 200,000,000 shares authorized, 23,560,250 and 23,491,881 shares issued and outstanding as of June 30, 2022 and December 31, 2021, respectively | 3 | 3 |
Additional paid-in capital | 216,731 | 214,685 |
Accumulated other comprehensive loss | (845) | (184) |
Accumulated deficit | (126,768) | (103,133) |
Total stockholders equity | 89,121 | 111,371 |
Total liabilities and stockholders’ equity | $ 104,515 | $ 126,486 |
CONDENSED BALANCE SHEETS (Paren
CONDENSED BALANCE SHEETS (Parenthetical) (Unaudited) - $ / shares | Jun. 30, 2022 | Dec. 31, 2021 |
Statement Of Financial Position [Abstract] | ||
Preferred Stock, Par Value | $ 0.0001 | $ 0.0001 |
Preferred stock, shares authorized | 10,000,000 | 10,000,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value | $ 0.0001 | $ 0.0001 |
Common stock, shares authorized | 200,000,000 | 200,000,000 |
Common stock, shares issued | 23,560,250 | 23,491,881 |
Common stock, shares outstanding | 23,560,250 | 23,491,881 |
CONDENSED STATEMENTS OF OPERATI
CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Operating expenses: | ||||
Research and development | $ 9,060 | $ 9,119 | $ 17,568 | $ 15,833 |
General and administrative | 2,822 | 2,595 | 6,048 | 5,698 |
Total operating expenses | 11,882 | 11,714 | 23,616 | 21,531 |
Loss from operations | (11,882) | (11,714) | (23,616) | (21,531) |
Interest expense | (94) | (80) | (181) | (169) |
Other income, net | 104 | 20 | 162 | 39 |
Net loss | (11,872) | (11,774) | (23,635) | (21,661) |
Unrealized loss on available for sale securities | (152) | (29) | (661) | (29) |
Comprehensive loss | $ (12,024) | $ (11,803) | $ (24,296) | $ (21,690) |
Net loss per share, basic and diluted | $ (0.51) | $ (0.50) | $ (1.01) | $ (0.93) |
Weighted-average shares of common stock outstanding, basic and diluted | 23,493,613 | 23,329,756 | 23,492,960 | 23,306,708 |
CONDENSED STATEMENT OF STOCKHOL
CONDENSED STATEMENT OF STOCKHOLDERS' EQUITY (Unaudited) - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Loss | Accumulated Deficit |
Balance at Dec. 31, 2020 | $ 149,427 | $ 2 | $ 210,266 | $ 0 | $ (60,841) |
Balance, Shares at Dec. 31, 2020 | 23,260,399 | ||||
Exercise of stock options | 143 | $ 1 | 142 | ||
Exercise of stock options, Shares | 99,544 | ||||
Issuance of common stock related to employee stock purchase plan | 96 | 96 | |||
Issuance of common stock related to employee stock purchase plan, Shares | 10,127 | ||||
Stock-based compensation | 2,130 | 2,130 | |||
Unrealized loss on available for sale securities | (29) | (29) | |||
Net loss | (21,661) | (21,661) | |||
Balance at Jun. 30, 2021 | 130,106 | $ 3 | 212,634 | (29) | (82,502) |
Balance, Shares at Jun. 30, 2021 | 23,370,070 | ||||
Balance at Mar. 31, 2021 | 140,723 | $ 2 | 211,449 | 0 | (70,728) |
Balance, Shares at Mar. 31, 2021 | 23,301,872 | ||||
Exercise of stock options | 80 | $ 1 | 79 | ||
Exercise of stock options, Shares | 58,071 | ||||
Issuance of common stock related to employee stock purchase plan | 96 | 96 | |||
Issuance of common stock related to employee stock purchase plan, Shares | 10,127 | ||||
Stock-based compensation | 1,010 | 1,010 | |||
Unrealized loss on available for sale securities | (29) | (29) | |||
Net loss | (11,774) | (11,774) | |||
Balance at Jun. 30, 2021 | 130,106 | $ 3 | 212,634 | (29) | (82,502) |
Balance, Shares at Jun. 30, 2021 | 23,370,070 | ||||
Balance at Dec. 31, 2021 | $ 111,371 | $ 3 | 214,685 | (184) | (103,133) |
Balance, Shares at Dec. 31, 2021 | 23,491,881 | 23,491,881 | |||
Exercise of stock options | $ 2 | 2 | |||
Exercise of stock options, Shares | 992 | ||||
Issuance of common stock related to employee stock purchase plan | 38 | 38 | |||
Issuance of common stock related to employee stock purchase plan, Shares | 25,545 | ||||
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings | (40) | (40) | |||
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings, shares | 41,832 | ||||
Stock-based compensation | 2,046 | 2,046 | |||
Unrealized loss on available for sale securities | (661) | (661) | |||
Net loss | (23,635) | (23,635) | |||
Balance at Jun. 30, 2022 | $ 89,121 | $ 3 | 216,731 | (845) | (126,768) |
Balance, Shares at Jun. 30, 2022 | 23,560,250 | 23,560,250 | |||
Balance at Mar. 31, 2022 | $ 100,243 | $ 3 | 215,828 | (693) | (114,895) |
Balance, Shares at Mar. 31, 2022 | 23,492,873 | ||||
Issuance of common stock related to employee stock purchase plan | 38 | 38 | |||
Issuance of common stock related to employee stock purchase plan, Shares | 25,545 | ||||
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings | (40) | (40) | |||
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings, shares | 41,832 | ||||
Stock-based compensation | 905 | 905 | |||
Unrealized loss on available for sale securities | (152) | (152) | |||
Net loss | (11,872) | (11,872) | |||
Balance at Jun. 30, 2022 | $ 89,121 | $ 3 | $ 216,731 | $ (845) | $ (126,768) |
Balance, Shares at Jun. 30, 2022 | 23,560,250 | 23,560,250 |
CONDENSED STATEMENTS OF CASH FL
CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2022 | Jun. 30, 2021 | |
Cash flows from operating activities | ||
Net loss | $ (23,635) | $ (21,661) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Stock-based compensation expense | 2,046 | 2,130 |
Depreciation and amortization | 27 | 30 |
Amortization of discount on investments | 108 | 3 |
Non-cash lease expense | 166 | 155 |
Changes in operating assets and liabilities: | ||
Prepaid expenses and other current assets | (285) | 1,186 |
Accounts payable and accrued expenses | 892 | (209) |
Accrued compensation and benefits | (582) | (112) |
Other assets | 27 | 31 |
Other liabilities | (131) | (34) |
Net cash used in operating activities | (21,367) | (18,481) |
Cash flows from investing activities | ||
Purchases of property and equipment | (6) | (22) |
Purchase of investments | (12,978) | (60,828) |
Proceeds from maturities of investments | 39,000 | 0 |
Net cash provided by (used in) investing activities | 26,016 | (60,850) |
Cash flows from financing activities | ||
Payment of deferred offering costs | (227) | 0 |
Proceeds from exercise of stock options | 2 | 143 |
Proceeds from issuance of common stock related to employee stock purchase plan | 38 | 96 |
Proceeds from issuance of long-term debt, net of issuance costs of $10 | 4,990 | |
Repayment of term loan | (4,770) | |
Net cash (used in) provided by financing activities | (187) | 459 |
Net increase (decrease) in cash, cash equivalents and restricted cash | 4,462 | (78,872) |
Cash, cash equivalents, and restricted cash at beginning of period | 42,964 | 157,366 |
Cash, cash equivalents, and restricted cash at end of period | 47,426 | 78,494 |
Supplemental cash flow data: | ||
Cash paid for interest | 110 | 97 |
Supplemental disclosure of non-cash investing and financing activities: | ||
Tax withholding payments on restricted stock units | (40) | 0 |
Deferred offering costs included in accounts payable and accrued expenses | $ 50 | $ 0 |
CONDENSED STATEMENTS OF CASH _2
CONDENSED STATEMENTS OF CASH FLOWS (Parenthetical) (Unaudited) $ in Thousands | 6 Months Ended |
Jun. 30, 2022 USD ($) | |
Statement Of Cash Flows [Abstract] | |
Proceeds from issuance of long-term debt, issuance costs | $ 10 |
Organization and Principal Acti
Organization and Principal Activities | 6 Months Ended |
Jun. 30, 2022 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Organization and Principal Activities | 1. Organization and Principal Activities Description of Business Spruce Biosciences, Inc. (the Company) is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The Company is initially developing its wholly-owned product candidate, tildacerfont, as the potential first non-steroidal therapy for patients suffering from classic congenital adrenal hyperplasia (CAH). The Company is also developing tildacerfont for females suffering from polycystic ovary syndrome (PCOS) with adrenal dysfunction. The Company is located in Daly City, California and was incorporated in the state of Delaware in April 2016. Liquidity and Capital Resources As of June 30, 2022, the Company had cash, cash equivalents and investments of $ 99.1 million, which management believes is sufficient to fund its planned operations for a period of at least twelve months following the issuance of the accompanying condensed financial statements. The Company has incurred significant losses and negative cash flows from operations. During the six months ended June 30, 2022, the Company incurred a net loss of $ 23.6 million and used $ 21.4 million of cash in operations. As of June 30, 2022, the Company had an accumulated deficit of $ 126.8 million and does not expect positive cash flows from operations in the foreseeable future. The Company has funded its operations primarily through the issuance and sale of equity securities and debt. The Company anticipates that it will need to raise substantial additional financing in the future to fund its operations. In order to meet these additional cash requirements, the Company may seek to sell additional equity or issue debt, convertible debt or other securities that may result in dilution to its stockholders. If the Company raises additional funds through the issuance of debt or convertible debt securities, these securities could have rights senior to those of its shares of common stock and could contain covenants that restrict its operations. There can be no assurance that the Company will be able to obtain additional equity or debt financing on terms acceptable to it, if at all. Additional debt financing, if available, would result in increased fixed payment obligations and may involve agreements that include covenants limiting or restricting the Company’s ability to take specific actions such as incurring debt, making capital expenditures or declaring dividends. The Company’s failure to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on its business, results of operations, and financial condition. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2022 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Interim Condensed Financial Statements The financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (U.S. GAAP) and applicable rules and regulations of the U.S. Securities and Exchange Commission (SEC) for interim reporting. As permitted under those rules and regulations, certain notes or other financial information normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. The condensed balance sheet as of June 30, 2022, the condensed statements of operations and comprehensive loss for the three and six months ended June 30, 2022 and 2021, the condensed statement of stockholders’ equity for the three and six months ended June 30, 2022 and 2021, and the condensed statements of cash flows for the six months ended June 30, 2022 and 2021 are unaudited. The interim condensed financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal, recurring adjustments that are necessary to present fairly the Company’s results for the interim periods presented. The condensed balance sheet as of December 31, 2021, is derived from the Company’s audited financial statements. The results of operations for the three and six months ended June 30, 2022, are not necessarily indicative of the results to be expected for the year ending December 31, 2022, or for any other future annual or interim period. These interim condensed financial statements should be read in conjunction with the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on March 14, 2022 (Annual Report). Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and expenses as well as related disclosure of contingent assets and liabilities. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, accrued research and development expenses, stock-based compensation and uncertain tax positions. The Company bases its estimates on its historical experience and on assumptions that it believes are reasonable; however, actual results could significantly differ from those estimates. Risks and Uncertainties Any product candidates developed by the Company will require approvals from the U.S. Food and Drug Administration (FDA) or foreign regulatory agencies prior to commercial sales. There can be no assurance that the Company’s current and future product candidates will meet desired efficacy and safety requirements to obtain the necessary approvals. If approval is denied or delayed, it may have a material adverse impact on the Company’s business and its financial statements. The Company is subject to a number of risks similar to other late-stage biopharmaceutical companies including, but not limited to, dependency on the clinical success of the Company’s product candidate, tildacerfont, ability to obtain regulatory approval of tildacerfont, the need for substantial additional financing to achieve its goals, uncertainty of broad adoption of its approved products, if any, by physicians and consumers, significant competition, untested manufacturing capabilities, and dependence on key individuals and sole source suppliers. The Company’s business has been and could continue to be adversely affected by the evolving COVID-19 pandemic. For example, the COVID-19 pandemic has resulted in and could result in delays to the Company’s clinical trials for numerous reasons including additional delays or difficulties in enrolling patients, diversion of healthcare resources away from the conduct of clinical trials, interruption or delays in the operations of the FDA or other regulatory authorities, and delays in clinical sites receiving the supplies and materials to conduct our clinical trials. At this time, the extent to which the COVID-19 pandemic impacts the Company’s business will depend on future developments, which are highly uncertain. While vaccines have become widely available in certain countries, and businesses and economies have reopened, the status of global economic recovery remains uncertain and unpredictable and will continue to be impacted by developments in the pandemic including any subsequent waves of outbreak or new variant strains of the COVID-19 virus which may require re-closures or other preventative measures. The Company will continue to evaluate the impact that these events could have on its future operations, financial position, results of operations and cash flows. Further, following the recent invasion of Ukraine by Russia, the U.S. and global financial markets experienced volatility, which has led to additional disruptions to trade, commerce, pricing stability, credit availability and supply chain continuity globally. It is uncertain what the long-term impact of the ongoing military conflict between Ukraine and Russia and related sanctions may have on the Company’s business. Significant Accounting Policies There have been no significant changes to the accounting policies during the six months ended June 30, 2022, as compared to the significant accounting policies described in the Annual Report. Restricted Cash The Company has cash in a collateral account related to a letter of credit issued on behalf of the Company for the security deposit on the non-cancelable operating lease for an office facility. The collateralized cash in connection with the letter of credit was classified as restricted cash on the balance sheet as of June 30, 2022 and December 31, 2021 based on the terms of the lease agreement, which expires in 2025, unless extended. The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, 2022 2021 Cash and cash equivalents $ 47,210 $ 78,278 Restricted cash 216 216 Total cash, cash equivalents and restricted cash $ 47,426 $ 78,494 Emerging Growth Company Status The Company is an emerging growth company (EGC) as defined in the Jumpstart Our Business Startups Act of 2012 (JOBS Act) and may take advantage of reduced reporting requirements that are otherwise applicable to public companies. Section 107 of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting standards until private companies are required to comply with those standards. The Company has elected to use the extended transition period for complying with new or revised accounting standards. Recent Accounting Pronouncements Not Yet Adopted In June 2016, the Financial Accounting Standards Board (FASB) issued ASU 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (ASU 2016-13). ASU 2016-13 requires companies to measure credit losses utilizing a methodology that reflects expected credit losses and requires a consideration of a broader range of reasonable and supportable information to inform credit loss estimates. ASU 2016-13 is effective for non-EGC’s electing to use the extended transition period for complying with new or revised accounting standards for fiscal years beginning after December 15, 2019, and for EGC’s for fiscal years beginning after December 15, 2022, with early adoption permitted. The Company expects to adopt this ASU on January 1, 2023. The Company is currently assessing the impact of adopting this standard, but based on a preliminary assessment, does not expect the adoption of this guidance to have a material impact on its financial statements. |
Cash Equivalents and Investment
Cash Equivalents and Investments | 6 Months Ended |
Jun. 30, 2022 | |
Investments Debt And Equity Securities [Abstract] | |
Cash Equivalents and Investments | 3. Cash Equivalents and Investments The Company considers all highly liquid investments with remaining maturities at the date of purchase of three months or less to be cash equivalents. Cash equivalents consist of amounts invested in money market funds and are stated at fair value. Investments are comprised of U.S. treasury securities, commercial paper, and corporate bonds. The following table is a summary of amortized cost, gross unrealized gains and losses, and fair value (in thousands): June 30, 2022 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Money market funds $ 44,320 $ — $ — $ 44,320 Total cash equivalents 44,320 — — 44,320 Corporate bonds 14,662 — ( 191 ) 14,471 U.S. treasury securities 32,080 — ( 466 ) 31,614 Total short-term investments 46,742 — ( 657 ) 46,085 U.S. treasury securities 5,994 — ( 189 ) 5,805 Total long-term investments 5,994 — ( 189 ) 5,805 Total cash equivalents and investments $ 97,056 $ — $ ( 845 ) * $ 96,210 *Total Gross Unrealized Losses in the table above does not recalculate due to rounding. As of June 30, 2022, $ 135 thousand of accrued interest on investments was recorded to other assets on the condensed balance sheets. December 31, 2021 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Money market funds $ 38,067 $ — $ — $ 38,067 Total cash equivalents 38,067 — — 38,067 Commercial paper 33,973 — — 33,973 Corporate bonds 6,285 — ( 23 ) 6,262 U.S. treasury securities 5,999 — ( 13 ) 5,986 Total short-term investments 46,257 — ( 36 ) 46,221 Corporate bonds 8,470 — ( 34 ) 8,436 U.S. treasury securities 24,137 — ( 114 ) 24,023 Total long-term investments 32,607 — ( 148 ) 32,459 Total cash equivalents and investments $ 116,931 $ — $ ( 184 ) $ 116,747 As of December 31, 2021, $ 135 thousand of accrued interest on investments was recorded to other assets on the condensed balance sheets. As of June 30, 2022, the weighted-average remaining contractual maturities of investments was approximately eight months . There have been no realized gains or losses on available for sale securities for the periods presented. No available for sale securities held as of June 30, 2022 have been in a continuous unrealized loss position for more than 12 months, and unrealized gains and losses are included in “accumulated other comprehensive loss” within stockholders' equity on the condensed balance sheets. As of June 30, 2022, unrealized losses on available for sale securities are not attributed to credit risk and are considered temporary. The Company believes that it is more-likely-than-not that investments in an unrealized loss position will be held until maturity or the cost basis of the investment will be recovered. The Company believes it has no other-than-temporary impairments on its securities as it does not intend to sell these securities and does not believe it is more likely than not that it will be required to sell these securities before the recovery of their amortized cost basis. To date, the Company has not recorded any impairment charges on securities related to other-than-temporary declines in fair value. The Company’s short-term investments are securities with contractual maturities of less than one year . |
Fair Value Measurements
Fair Value Measurements | 6 Months Ended |
Jun. 30, 2022 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | 4. Fair Value Measurements The Company measures and reports certain financial instruments as assets at fair value. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability, or an exit price, in the principal or most advantageous market for that asset or liability in an orderly transaction between market participants on the measurement date. Fair value measurement establishes a fair value hierarchy that requires an entity to maximize the use of observable inputs, where available, and minimize the use of unobservable inputs when measuring fair value. The Company determined the fair value of financial assets and liabilities using the fair value hierarchy that describes three levels of inputs that may be used to measure fair value, as follows: Level 1—Quoted prices in active markets for identical assets and liabilities; Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities; and Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. The carrying value of cash and cash equivalents, prepaid expenses, accounts payable, and accrued expenses are generally considered to be representative of their respective fair values because of the short-term nature of those instruments. The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): June 30, 2022 Total Level 1 Level 2 Level 3 Money market funds $ 44,320 $ 44,320 $ — $ — Total cash equivalents 44,320 44,320 — — Corporate bonds 14,471 14,471 — — U.S. treasury securities 31,614 31,614 — — Total short-term investments 46,085 46,085 — — U.S. treasury securities 5,805 5,805 — — Total long-term investments 5,805 5,805 — — Total cash equivalents and investments $ 96,210 $ 96,210 $ — $ — As of June 30, 2022, $ 135 thousand of accrued interest on investments was recorded to other assets on the condensed balance sheets. December 31, 2021 Total Level 1 Level 2 Level 3 Money market funds $ 38,067 $ 38,067 $ — $ — Total cash equivalents 38,067 38,067 — — Commercial paper 33,973 — 33,973 — Corporate bonds 6,262 6,262 — U.S. treasury securities 5,986 5,986 — — Total short-term investments 46,221 12,248 33,973 — Corporate bonds 8,436 8,436 — — U.S. treasury securities 24,023 24,023 — — Total long-term investments 32,459 32,459 — — Total cash equivalents and investments $ 116,747 $ 82,774 $ 33,973 $ - As of December 31, 2021, $ 135 thousand of accrued interest on investments was recorded to other assets on the condensed balance sheets. The Company's assets and liabilities that are recorded at fair value on a recurring or non-recurring basis as of June 30, 2022 are described below. For Level 1 investments, the Company uses quoted prices in active markets for identical assets to determine the fair value. For Level 2 investments, the Company uses quoted prices for similar assets sourced from certain third-party pricing services. The third-party pricing services generally utilize industry standard valuation models for which all significant inputs are observable, either directly or indirectly, to estimate the price or fair value of the securities. The primary input generally includes reported trades of or quotes on the same or similar securities. The Company does not make additional judgments or assumptions made to the pricing data sourced from the third-party pricing services. The estimated fair value of the term loan was $ 4.7 million as of June 30, 2022 and was based on estimated interest rates currently available to the Company for debt with similar terms, a Level 3 input. |
Balance Sheet Components
Balance Sheet Components | 6 Months Ended |
Jun. 30, 2022 | |
Text Block [Abstract] | |
Balance Sheet Components | 5. Balance Sheet Components Property and equipment, net Property and equipment, net consisted of the following (in thousands): June 30, December 31, 2022 2021 Computer and office equipment $ 20 $ 15 Computer software 27 27 Manufacturing machinery and equipment 58 58 Leasehold improvements 7 7 Furniture and fixtures 64 64 Less: accumulated depreciation ( 49 ) ( 31 ) Property and equipment, net $ 127 $ 140 Property and equipment, net is included in other assets on the condensed balance sheets. Depreciation expense was $ 9 thousand and $ 18 thousand for the three and six months ended June 30, 2022, respectively. Depreciation expense was $ 5 thousand and $ 9 thousand for the three and six months ended June 30, 2021, respectively. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consisted of the following (in thousands): June 30, December 31, Accrued research and development expenses $ 6,226 $ 3,837 Accrued general and administrative expenses 347 416 Lease liability, current portion 380 360 Total accrued expenses and other current liabilities $ 6,953 $ 4,613 Accrued research and development expenses were primarily related to clinical trials and manufacturing of clinical drug supply. |
Leases
Leases | 6 Months Ended |
Jun. 30, 2022 | |
Leases [Abstract] | |
Leases | 6. Leases The Company leases space under non-cancelable operating lease, which requires the Company to pay base rent, real estate taxes, insurance, general repairs, and maintenance. The Company does not have financing leases. In February 2020, the Company entered into a non-cancelable operating lease for office space with a commencement date of September 2020 . The monthly payments escalate over the 63 -month term with total gross commitments of $ 2.3 million. The lease includes an option to renew the lease term for an additional period of 60 months. The renewal option is not included in the lease term as the Company is not reasonably certain to exercise the option. Lease incentives, which relate to rent abatement, were considered in the calculation of the lease liability and right-of-use asset. Lease expense for the three and six months ended June 30, 2022 was $ 0.1 million and $ 0.2 million, respectively. Lease expense for the three and six months ended June 30, 2021 was $ 0.1 million and $ 0.2 million, respectively. Lease right-of-use assets and liabilities are recognized at the commencement date based on the present value of the remaining minimum lease payments over the lease term, with certain adjustments. As the leases do not provide an implicit rate, the Company uses a collateralized incremental borrowing rate based on the information available at the commencement date to determine the lease liability. As of June 30, 2022, the weighted-average remaining lease term for operating leases was 3.4 years and the weighted-average discount rate was 7.0 %. Cash paid for amounts included in the measurement of lease liabilities was $ 0.1 million and $ 0.2 million for the three and six months ended June 30, 2022, respectively. Cash paid for amounts included in the measurement of lease liabilities was $ 0.1 million and $ 0.1 million for the three and six months ended June 30, 2021, respectively. The Company recognizes monthly operating lease expense on a straight-line basis over the term of the lease. Variable lease expense relates primarily to office lease common area maintenance, insurance, and property taxes, is expensed as incurred, and is excluded from the calculation of the lease liability and right-of-use-asset. |
Term Loan
Term Loan | 6 Months Ended |
Jun. 30, 2022 | |
Debt Disclosure [Abstract] | |
Term Loan | 7. Term Loan In September 2019, the Company entered into a Loan and Security Agreement (the Loan Agreement) with Silicon Valley Bank (SVB) providing for a term loan (the Term Loan). In April 2020, the Company and SVB entered into an agreement (the Deferral Agreement) whereby the parties agreed to extend the interest-only period and repayment dates of all monthly payments of principal due and the maturity date with respect to the Term Loan by six months . All other terms under the Loan Agreement remained unchanged at that time. The Deferral Agreement was determined to be a debt modification, resulting in a prospective yield adjustment based on the revised terms. In connection with the Loan Agreement, the Company issued a warrant to purchase up to an aggregate of 49,609 shares of common stock at $ 1.44 per share. The Company determined the initial fair value of the warrant to be $ 0.1 million using the Black-Scholes option-pricing model. The fair value of the warrant was recorded to equity and as a debt discount, which was being amortized to interest expense using the effective interest method over the term of the Term Loan. In November 2020, the warrant was net-exercised for 46,358 shares of common stock. In March 2021, the Company entered into a First Amendment to Loan and Security Agreement (the First Amendment), pursuant to which the Company and SVB amended the Loan Agreement. The First Amendment increased the aggregate principal amount of the Term Loan commitment by SVB to up to $ 30.0 million. Up to $ 20.0 million was available under the first tranche of the Term Loan (First Tranche), $ 5.0 million of which was advanced immediately to repay the outstanding obligations under the Term Loan prior to the First Amendment with the remainder of the First Tranche commitment available through December 31, 2021 , and up to $ 10.0 million is available under the second tranche (Second Tranche), subject to the completion of certain clinical or financial milestones, which Second Tranche commitment is available through December 31, 2022 . Pursuant to the First Amendment, the Term Loan will mature on January 1, 2026 . The First Amendment was determined to be a debt modification. Pursuant to the First Amendment, the Company is required to make monthly payments of interest only commencing on the first day of the month following the funding date of each respective tranche and continuing thereafter through December 31, 2022 to the extent that the Company does not borrow any part of the Second Tranche or December 31, 2023 if the Company has borrowed some or all of the Second Tranche. Outstanding principal balances under the Term Loan, as amended by the First Amendment, bear interest at a floating per annum rate equal to (A) if the Company does not borrow under the Second Tranche, the greater of (x) 1 % above the prime rate or (y) 4.25 %; or (B) if the Company does borrow under the Second Tranche, the greater of (x) 3 % above the prime rate or (y) 6.25 %. In May 2022, the Company entered into a Second Amendment to Loan and Security Agreement (the Second Amendment), which amended the milestones upon which the Second Tranche commitment of $ 10.0 million would become available. The Second Amendment was determined to be a debt modification. The Second Amendment reduced the interest rate on the outstanding First Tranche Term Loan of $ 5.0 million and any advances that occur under the Second Tranche to a floating per annum rate equal to the greater of (A) one-half of one percent ( 0.50 %) above the Prime Rate (as defined in the Loan Agreement) or (B) three and three-quarters of one percent ( 3.75 %), and, in the event that the Supplemental Term Loans (as defined in the Loan Agreement) under the Second Tranche become available and the Company obtains an advance thereunder, the interest only period for all Term Loans (as defined in the Loan Agreement) will be extended from December 31, 2022, to June 30, 2023. Further, in the event that the Supplemental Term Loans under the Second Tranche become available and the Company obtains an advance thereunder, the Company will be required to comply with a new liquidity covenant of at least $50.0 million at all times. If the Company does not comply with the foregoing liquidity covenant, a springing cash pledge will occur, pursuant to which the Company must maintain a cash secured blocked account with SVB with a cash balance in an amount equal to the outstanding SVB obligations at such time (excluding Bank Services (as defined in the Loan Agreement)). The foregoing cash collateral requirement will terminate upon a certain additional equity raise, which must occur on or before September 30, 2024. The Loan Agreement, as amended by the Deferral Agreement, the First Amendment, and the Second Amendment, provides for monthly cash interest-only payments following the funding date of each respective tranche and continuing thereafter through December 31, 2022 to the extent that the Company does not borrow any part of the Second Tranche or June 30, 2023 if the Company has borrowed some or all of the Second Tranche. Following the interest-only period, the outstanding Term Loan balance will be payable in (i) 37 consecutive monthly payments (or 31 if the Company borrows under the Second Tranche) after the end of the interest-only period and continuing on the same day of each month thereafter, in amounts that would fully amortize such Term Loan balance, as of the first business day of the first month following the amended interest-only period, over the repayment period, plus (ii) monthly payments of accrued but unpaid interest. The Second Amendment amended the Second Tranche Final Payment due on the maturity date, which payments shall include all outstanding principal and all accrued unpaid interest and an end of term payment totaling (x) 6.0 % of the original funded principal amount of the First Tranche, and (y) 4.0 % of the total original funded principal amount under the Second Tranche if the Company does borrow under the Second Tranche (the Supplemental Final Payment). The Second Amendment also amended the prepayment amounts, so that the Company may prepay amounts outstanding under the Term Loan at any time provided certain notification conditions are met, in which case, all outstanding principal plus accrued and unpaid interest, the Supplemental Final Payment, a prepayment fee of 1 % or 2 % of the principal amount of the first and second tranches, and any bank expenses become due and payable. The Company incurred $ 10.0 thousand of debt issuance costs in connection with the First Amendment and $ 15.6 thousand of debt issuance costs in connection with the Second Amendment. The Company recorded these costs, including the unaccreted portion of the final payment obligation under the Loan Agreement as a discount from the carrying value of the Term Loan, which are being amortized using the effective interest method over the life of the First Amendment. The unamortized debt issuance costs and debt discount balance was $ 0.1 million as of June 30, 2022. The Term Loan and unamortized discount and debt issuance costs balances as of June 30, 2022 are shown below (in thousands): June 30, Total Term Loan debt $ 5,000 Less: unamortized discount and debt issuance costs ( 112 ) Total Term Loan, net 4,888 Less: Term Loan, current portion ( 811 ) Term loan, net of current portion $ 4,077 The Company is subject to customary affirmative and restrictive covenants under the Loan Agreement, as amended. The Company’s obligations under the Loan Agreement, as amended, are secured by a first priority security interest in substantially all of its current and future assets, other than intellectual property. The Company also agreed not to encumber its intellectual property assets, except as permitted by the Loan Agreement, as amended. The Loan Agreement, as amended, also contains customary indemnification obligations and customary events of default, including, among other things, the Company’s failure to fulfill certain obligations under the Loan Agreement, as amended, and the occurrence of a material adverse change in its business, operations, or condition (financial or otherwise), a material impairment of the prospect of repayment of any portion of the loan, or a material impairment in the perfection or priority of lender’s lien in the collateral or in the value of such collateral. In the event of default by the Company under the Loan Agreement, as amended, the lender would be entitled to exercise their remedies thereunder, including the right to accelerate the debt, upon which the Company may be required to repay all amounts then outstanding under the Loan Agreement, as amended. As of June 30, 2022, management believes that the Company was in compliance with all financial covenants under the Loan Agreement, as amended, and there had been no material adverse change. The Company made interest payments on the Term Loan of $ 57 thousand and $ 110 thousand during the three and six months ended June 30, 2022, respectively. The Company made interest payments on the Term Loan of $ 43 thousand and $ 97 thousand during the three and six months ended June 30, 2021, respectively. |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2022 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 8. Commitments and Contingencies From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of business. The Company evaluates the likelihood of an unfavorable outcome in legal or regulatory proceedings to which it is a party and records a loss contingency on an undiscounted basis when it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. These judgments are subjective and based on the status of such legal proceedings, the merits of the Company’s defenses, and consultation with legal counsel. Actual outcomes of these legal proceedings may differ materially from the Company’s estimates. License Agreement In May 2016, the Company entered into a license agreement (the License Agreement), with Eli Lilly and Company (Lilly). Pursuant to the terms of the License Agreement, Lilly granted the Company an exclusive, worldwide, royalty bearing, sublicensable license under certain technology, patent rights, know-how and proprietary materials related to certain compounds, to research, develop, and commercialize such compounds for all pharmaceutical uses. The Company is also required to pay Lilly up to an aggregate of $ 23.0 million upon the achievement, during the time the License Agreement remains in effect, of certain milestones relating to the clinical development and commercial sales of products licensed under the License Agreement. Such payments are for predetermined fixed amounts, are paid only upon the first occurrence of each event and are due shortly after achieving the applicable milestone. In addition, the Company is required to pay Lilly tiered royalties on annual worldwide net sales with rates ranging from mid-single digits to sub-teens. No additional amounts were paid by the Company to Lilly during any of the periods presented, nor were due as of such dates pursuant to the License Agreement. Legal Matters The Company’s industry is characterized by frequent claims and litigation, including claims regarding intellectual property. As a result, the Company may be subject to various legal proceedings from time to time. The results of any future litigation cannot be predicted with certainty, and regardless of the outcome, litigation can have an adverse impact on the Company because of defense and settlement costs, diversion of management resources and other factors. The Company was no t subject to any material legal proceedings during the six months ended June 30, 2022. |
Capital Structure
Capital Structure | 6 Months Ended |
Jun. 30, 2022 | |
Equity [Abstract] | |
Capital Structure | 9. Capital Structure Common Stock As of June 30, 2022 and December 31, 2021, the Company was authorized to issue 200,000,000 shares of common stock $ 0.0001 par value per share. Holders of the Company’s common stock are entitled to dividends if and when declared by the Board of Directors of the Company (Board of Directors). The holder of each share of common stock is entitled to one vote . As of June 30, 2022, no dividends were declared. Shares reserved for future issuance Common stock reserved for future issuance, on an as converted basis, consisted of the following: June 30, December 31, Stock options, issued and outstanding 3,954,980 2,215,942 Restricted and performance stock units, issued and outstanding 425,853 460,000 Shares available for future issuance under 2020 Equity Incentive Plan 2,815,275 2,636,506 Employee stock purchase plan, available for future issuance 642,573 433,200 Total shares reserved 7,838,681 5,745,648 In February 2022, the SEC declared effective a registration statement on Form S-3 (Shelf Registration) covering the sale of up to $ 200.0 million of the Company's securities. Also, in February 2022, the Company entered into an Open Market Sales Agreement SM (Sales Agreement), with Jefferies LLC (Jefferies), pursuant to which the Company may elect to issue and sell, from time to time, shares of common stock having an aggregate offering price of up to $ 21.0 million under the Shelf Registration through Jefferies acting as the sales agent and/or principal. As of June 30, 2022, the Company has issued no shares of common stock pursuant to the Sales |
Equity Incentive Plans and Stoc
Equity Incentive Plans and Stock-Based Compensation Expense | 6 Months Ended |
Jun. 30, 2022 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Equity Incentive Plans and Stock-Based Compensation Expense | 10. Equity Incentive Plans and Stock-Based Compensation Expense Equity Incentive Plans The Company adopted the 2020 Equity Incentive Plan (the 2020 Plan) in October 2020. The 2020 Plan is a successor to and continuation of the Amended and Restated 2016 Equity Incentive Plan (the 2016 Plan) and provides for the granting of stock options, stock appreciation rights, restricted stock, restricted stock units, and other stock or cash-based awards to individuals who are then employees, officers, directors or consultants. A total of 2,647,684 shares of common stock were approved to be initially reserved for issuance under the 2020 Plan, inclusive of the shares that remained available for issuance under the 2016 Plan at the time the 2020 Plan became effective. In addition, the number of shares of common stock available for issuance under the 2020 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2020 Plan, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to 5 % of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year or such lesser amount as determined by the Company’s Board of Directors. No further grants will be made under the 2016 Plan; however, shares subject to awards granted under the 2016 Plan will continue to be governed by the 2016 Plan. Under the 2020 Plan and the 2016 Plan, individuals can be granted the ability to early exercise their options. There were no shares, related to the early exercise of options, subject to repurchase by the Company as of June 30, 2022. As of June 30, 2022, a total of 4,985,297 shares were authorized for issuance under the 2020 Plan and 2,815,275 shares remained available for issuance, and a total of 1,275,158 shares were authorized for issuance under the 2016 Plan and no shares remained available for issuance. A summary of the Company’s stock option activity and related information is as follows (in thousands, except share and per share amounts): Outstanding Weighted- Weighted- Aggregate Balance as of December 31, 2021 2,215,942 $ 4.72 6.9 $ 3,959 Granted 2,143,125 3.23 — — Exercised ( 992 ) 1.39 — — Forfeited ( 403,095 ) 7.47 — — Balance as of June 30, 2022 3,954,980 $ 3.63 8.1 $ 410 Vested and expected to vest as of June 30, 2022 3,814,980 $ 3.59 8.0 $ 410 Vested and exercisable as of June 30, 2022 1,461,195 $ 3.57 5.4 $ 292 Stock options vested and expected to vest differs from total stock options outstanding as it excludes performance-based stock options for which the performance criteria have not been achieved and achievement is not expected as of June 30, 2022. The aggregate intrinsic values of options outstanding and exercisable were calculated as the difference between the exercise price of the options and the estimated fair value of the Company’s common stock as of the respective balance sheet date. The total intrinsic value of options exercised was $ 1 thousand for the six months ended June 30, 2022. There were no options exercised during the three months ended June 30, 2022. For the three and six months ended June 30, 2022, the weighted-average fair value of options granted was $ 1.47 per share and $ 2.56 per share, respectively. Restricted Stock Units (RSUs) A summary of the Company’s RSU activity and related information is as follows: RSUs Shares Weight-Average Grant Date Fair Value Per Share Unvested balance as of December 31, 2021 460,000 $ 2.48 Granted 92,200 2.58 Vested ( 64,347 ) 2.49 Forfeited ( 62,000 ) 2.55 Unvested balance as of June 30, 2022 425,853 $ 2.49 During the six months ended June 30, 2022, the Company granted 92,200 RSUs, including 68,775 RSUs subject to time-based vesting in installments through June 30, 2023, and 23,425 RSUs subject to performance-based vesting conditions related to the satisfaction of certain clinical development milestones. Employee Stock Purchase Plan The Board of Directors adopted and the Company’s stockholders approved the 2020 Employee Stock Purchase Plan (the ESPP) in October 2020. The ESPP allows eligible employees to purchase shares of the Company’s common stock at a discount through payroll deductions of up to 15 % of their eligible compensation. At the end of each purchase period, employees are able to purchase shares at 85 % of the lower of the fair market value of the Company’s common stock as of the offering date or the applicable purchase date. A total of 220,640 shares of common stock were approved to be initially reserved for issuance under the ESPP. In addition, the number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten-years of the term of the ESPP, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to the lesser of (i) 1 % of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year, (ii) 441,280 shares of common stock or (iii) such lesser amount as determined by the Board of Directors. During the six months ended June 30, 2022, 25,545 shares were issued under the ESPP. As of June 30, 2022, 642,573 shares of common stock remained available for issuance under the ESPP. Stock-Based Compensation Expense The following table summarizes the components of stock-based compensation expense recognized in the Company’s condensed statements of operations and comprehensive loss during the three and six months ended June 30, 2022 and 2021 (in thousands): Three Months Ended Six Months Ended 2022 2021 2022 2021 Research and development $ 245 $ 346 $ 545 $ 610 General and administrative 660 664 1,501 1,520 Total stock-based compensation expense $ 905 $ 1,010 $ 2,046 $ 2,130 As of June 30, 2022, there was approximately $ 7.4 million of unrecognized stock-based compensation expense related to stock options, which is expected to be recognized over a weighted-average vesting term of 2.9 years. As of June 30, 2022, there was approximately $ 0.6 million of unrecognized stock-based compensation expense related to RSUs, which is expected to be recognized over an estimated weighted-average vesting term of 1.3 years. |
Income Taxes
Income Taxes | 6 Months Ended |
Jun. 30, 2022 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | 11. Income Taxes The Company accounts for income taxes under ASC Topic 740, Income Taxes. Under this standard, deferred tax assets and liabilities are recognized for future tax benefits or consequences attributable to temporary differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. A valuation allowance is provided for significant deferred tax assets when it is more likely than not that such assets will not be realized through future operations. No provision for income taxes has been recorded due to losses incurred to date. Future tax benefits which may arise as a result of these losses have not been recognized in these financial statements, as their realization is determined not likely to occur and accordingly, the Company has recorded a full valuation allowance for deferred tax assets. |
Net Loss Per Share
Net Loss Per Share | 6 Months Ended |
Jun. 30, 2022 | |
Earnings Per Share [Abstract] | |
Net Loss Per Share | 12. Net Loss Per Share The following table sets forth the computation of the basic and diluted net loss per share (in thousands, except share and per share amounts): Three Months Ended Six Months Ended 2022 2021 2022 2021 Numerator: Net loss $ ( 11,872 ) $ ( 11,774 ) $ ( 23,635 ) $ ( 21,661 ) Denominator: Weighted-average shares of common stock outstanding 23,493,613 23,329,756 23,492,960 23,306,708 Net loss per share, basic and diluted $ ( 0.51 ) $ ( 0.50 ) $ ( 1.01 ) $ ( 0.93 ) Basic net loss per share was the same as diluted net loss per share for all periods as the inclusion of potentially dilutive securities would have been anti-dilutive. Potentially dilutive securities that were not included in the diluted per share calculations were as follows: June 30, 2022 2021 Shares subject to outstanding common stock options 3,954,980 2,612,963 Shares subject to outstanding RSUs 425,853 — Estimated shares issuable under the ESPP 138,365 32,255 Total 4,519,198 2,645,218 |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2022 | |
Accounting Policies [Abstract] | |
Interim Condensed Financial Statements | Interim Condensed Financial Statements The financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (U.S. GAAP) and applicable rules and regulations of the U.S. Securities and Exchange Commission (SEC) for interim reporting. As permitted under those rules and regulations, certain notes or other financial information normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. The condensed balance sheet as of June 30, 2022, the condensed statements of operations and comprehensive loss for the three and six months ended June 30, 2022 and 2021, the condensed statement of stockholders’ equity for the three and six months ended June 30, 2022 and 2021, and the condensed statements of cash flows for the six months ended June 30, 2022 and 2021 are unaudited. The interim condensed financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal, recurring adjustments that are necessary to present fairly the Company’s results for the interim periods presented. The condensed balance sheet as of December 31, 2021, is derived from the Company’s audited financial statements. The results of operations for the three and six months ended June 30, 2022, are not necessarily indicative of the results to be expected for the year ending December 31, 2022, or for any other future annual or interim period. These interim condensed financial statements should be read in conjunction with the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on March 14, 2022 (Annual Report). |
Use of Estimates | Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and expenses as well as related disclosure of contingent assets and liabilities. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, accrued research and development expenses, stock-based compensation and uncertain tax positions. The Company bases its estimates on its historical experience and on assumptions that it believes are reasonable; however, actual results could significantly differ from those estimates. |
Risks and Uncertainties | Risks and Uncertainties Any product candidates developed by the Company will require approvals from the U.S. Food and Drug Administration (FDA) or foreign regulatory agencies prior to commercial sales. There can be no assurance that the Company’s current and future product candidates will meet desired efficacy and safety requirements to obtain the necessary approvals. If approval is denied or delayed, it may have a material adverse impact on the Company’s business and its financial statements. The Company is subject to a number of risks similar to other late-stage biopharmaceutical companies including, but not limited to, dependency on the clinical success of the Company’s product candidate, tildacerfont, ability to obtain regulatory approval of tildacerfont, the need for substantial additional financing to achieve its goals, uncertainty of broad adoption of its approved products, if any, by physicians and consumers, significant competition, untested manufacturing capabilities, and dependence on key individuals and sole source suppliers. The Company’s business has been and could continue to be adversely affected by the evolving COVID-19 pandemic. For example, the COVID-19 pandemic has resulted in and could result in delays to the Company’s clinical trials for numerous reasons including additional delays or difficulties in enrolling patients, diversion of healthcare resources away from the conduct of clinical trials, interruption or delays in the operations of the FDA or other regulatory authorities, and delays in clinical sites receiving the supplies and materials to conduct our clinical trials. At this time, the extent to which the COVID-19 pandemic impacts the Company’s business will depend on future developments, which are highly uncertain. While vaccines have become widely available in certain countries, and businesses and economies have reopened, the status of global economic recovery remains uncertain and unpredictable and will continue to be impacted by developments in the pandemic including any subsequent waves of outbreak or new variant strains of the COVID-19 virus which may require re-closures or other preventative measures. The Company will continue to evaluate the impact that these events could have on its future operations, financial position, results of operations and cash flows. Further, following the recent invasion of Ukraine by Russia, the U.S. and global financial markets experienced volatility, which has led to additional disruptions to trade, commerce, pricing stability, credit availability and supply chain continuity globally. It is uncertain what the long-term impact of the ongoing military conflict between Ukraine and Russia and related sanctions may have on the Company’s business. |
Significant Accounting Policies | Significant Accounting Policies There have been no significant changes to the accounting policies during the six months ended June 30, 2022, as compared to the significant accounting policies described in the Annual Report. |
Restricted Cash | Restricted Cash The Company has cash in a collateral account related to a letter of credit issued on behalf of the Company for the security deposit on the non-cancelable operating lease for an office facility. The collateralized cash in connection with the letter of credit was classified as restricted cash on the balance sheet as of June 30, 2022 and December 31, 2021 based on the terms of the lease agreement, which expires in 2025, unless extended. The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, 2022 2021 Cash and cash equivalents $ 47,210 $ 78,278 Restricted cash 216 216 Total cash, cash equivalents and restricted cash $ 47,426 $ 78,494 |
Emerging Growth Company Status | Emerging Growth Company Status The Company is an emerging growth company (EGC) as defined in the Jumpstart Our Business Startups Act of 2012 (JOBS Act) and may take advantage of reduced reporting requirements that are otherwise applicable to public companies. Section 107 of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting standards until private companies are required to comply with those standards. The Company has elected to use the extended transition period for complying with new or revised accounting standards. |
Recent Accounting Pronouncements Not Yet Adopted | Recent Accounting Pronouncements Not Yet Adopted In June 2016, the Financial Accounting Standards Board (FASB) issued ASU 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (ASU 2016-13). ASU 2016-13 requires companies to measure credit losses utilizing a methodology that reflects expected credit losses and requires a consideration of a broader range of reasonable and supportable information to inform credit loss estimates. ASU 2016-13 is effective for non-EGC’s electing to use the extended transition period for complying with new or revised accounting standards for fiscal years beginning after December 15, 2019, and for EGC’s for fiscal years beginning after December 15, 2022, with early adoption permitted. The Company expects to adopt this ASU on January 1, 2023. The Company is currently assessing the impact of adopting this standard, but based on a preliminary assessment, does not expect the adoption of this guidance to have a material impact on its financial statements. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Accounting Policies [Abstract] | |
Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash | The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, 2022 2021 Cash and cash equivalents $ 47,210 $ 78,278 Restricted cash 216 216 Total cash, cash equivalents and restricted cash $ 47,426 $ 78,494 |
Cash Equivalents and Investme_2
Cash Equivalents and Investments (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Investments Debt And Equity Securities [Abstract] | |
Summary of Amortized Cost, Unrealized Gains, and Losses, and Fair Value | The following table is a summary of amortized cost, gross unrealized gains and losses, and fair value (in thousands): June 30, 2022 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Money market funds $ 44,320 $ — $ — $ 44,320 Total cash equivalents 44,320 — — 44,320 Corporate bonds 14,662 — ( 191 ) 14,471 U.S. treasury securities 32,080 — ( 466 ) 31,614 Total short-term investments 46,742 — ( 657 ) 46,085 U.S. treasury securities 5,994 — ( 189 ) 5,805 Total long-term investments 5,994 — ( 189 ) 5,805 Total cash equivalents and investments $ 97,056 $ — $ ( 845 ) * $ 96,210 *Total Gross Unrealized Losses in the table above does not recalculate due to rounding. December 31, 2021 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Money market funds $ 38,067 $ — $ — $ 38,067 Total cash equivalents 38,067 — — 38,067 Commercial paper 33,973 — — 33,973 Corporate bonds 6,285 — ( 23 ) 6,262 U.S. treasury securities 5,999 — ( 13 ) 5,986 Total short-term investments 46,257 — ( 36 ) 46,221 Corporate bonds 8,470 — ( 34 ) 8,436 U.S. treasury securities 24,137 — ( 114 ) 24,023 Total long-term investments 32,607 — ( 148 ) 32,459 Total cash equivalents and investments $ 116,931 $ — $ ( 184 ) $ 116,747 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Fair Value Disclosures [Abstract] | |
Summary of Financial Assets Measured at Fair Value on Recurring Basis | The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): June 30, 2022 Total Level 1 Level 2 Level 3 Money market funds $ 44,320 $ 44,320 $ — $ — Total cash equivalents 44,320 44,320 — — Corporate bonds 14,471 14,471 — — U.S. treasury securities 31,614 31,614 — — Total short-term investments 46,085 46,085 — — U.S. treasury securities 5,805 5,805 — — Total long-term investments 5,805 5,805 — — Total cash equivalents and investments $ 96,210 $ 96,210 $ — $ — December 31, 2021 Total Level 1 Level 2 Level 3 Money market funds $ 38,067 $ 38,067 $ — $ — Total cash equivalents 38,067 38,067 — — Commercial paper 33,973 — 33,973 — Corporate bonds 6,262 6,262 — U.S. treasury securities 5,986 5,986 — — Total short-term investments 46,221 12,248 33,973 — Corporate bonds 8,436 8,436 — — U.S. treasury securities 24,023 24,023 — — Total long-term investments 32,459 32,459 — — Total cash equivalents and investments $ 116,747 $ 82,774 $ 33,973 $ - |
Balance Sheet Components (Table
Balance Sheet Components (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Balance Sheet Components Disclosure [Abstract] | |
Schedule of Accrued Expenses and Other Current Liabilities | Accrued expenses and other current liabilities consisted of the following (in thousands): June 30, December 31, Accrued research and development expenses $ 6,226 $ 3,837 Accrued general and administrative expenses 347 416 Lease liability, current portion 380 360 Total accrued expenses and other current liabilities $ 6,953 $ 4,613 |
Schedule of Property and equipment | Property and equipment, net consisted of the following (in thousands): June 30, December 31, 2022 2021 Computer and office equipment $ 20 $ 15 Computer software 27 27 Manufacturing machinery and equipment 58 58 Leasehold improvements 7 7 Furniture and fixtures 64 64 Less: accumulated depreciation ( 49 ) ( 31 ) Property and equipment, net $ 127 $ 140 |
Term Loan (Tables)
Term Loan (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Debt Disclosure [Abstract] | |
Schedule of Term Loan | The Term Loan and unamortized discount and debt issuance costs balances as of June 30, 2022 are shown below (in thousands): June 30, Total Term Loan debt $ 5,000 Less: unamortized discount and debt issuance costs ( 112 ) Total Term Loan, net 4,888 Less: Term Loan, current portion ( 811 ) Term loan, net of current portion $ 4,077 |
Capital Structure (Tables)
Capital Structure (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Equity [Abstract] | |
Summary of Common Stock Reserved for Future Issuance | Common stock reserved for future issuance, on an as converted basis, consisted of the following: June 30, December 31, Stock options, issued and outstanding 3,954,980 2,215,942 Restricted and performance stock units, issued and outstanding 425,853 460,000 Shares available for future issuance under 2020 Equity Incentive Plan 2,815,275 2,636,506 Employee stock purchase plan, available for future issuance 642,573 433,200 Total shares reserved 7,838,681 5,745,648 |
Equity Incentive Plans and St_2
Equity Incentive Plans and Stock-Based Compensation Expense (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Stock Option Activity | A summary of the Company’s stock option activity and related information is as follows (in thousands, except share and per share amounts): Outstanding Weighted- Weighted- Aggregate Balance as of December 31, 2021 2,215,942 $ 4.72 6.9 $ 3,959 Granted 2,143,125 3.23 — — Exercised ( 992 ) 1.39 — — Forfeited ( 403,095 ) 7.47 — — Balance as of June 30, 2022 3,954,980 $ 3.63 8.1 $ 410 Vested and expected to vest as of June 30, 2022 3,814,980 $ 3.59 8.0 $ 410 Vested and exercisable as of June 30, 2022 1,461,195 $ 3.57 5.4 $ 292 |
Summary of RSU Activity | A summary of the Company’s RSU activity and related information is as follows: RSUs Shares Weight-Average Grant Date Fair Value Per Share Unvested balance as of December 31, 2021 460,000 $ 2.48 Granted 92,200 2.58 Vested ( 64,347 ) 2.49 Forfeited ( 62,000 ) 2.55 Unvested balance as of June 30, 2022 425,853 $ 2.49 |
Summary of Stock-Based Compensation Expense | The following table summarizes the components of stock-based compensation expense recognized in the Company’s condensed statements of operations and comprehensive loss during the three and six months ended June 30, 2022 and 2021 (in thousands): Three Months Ended Six Months Ended 2022 2021 2022 2021 Research and development $ 245 $ 346 $ 545 $ 610 General and administrative 660 664 1,501 1,520 Total stock-based compensation expense $ 905 $ 1,010 $ 2,046 $ 2,130 |
Net Loss Per Share (Tables)
Net Loss Per Share (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Earnings Per Share [Abstract] | |
Schedule of Computation of Basic and Diluted Net Loss Per Share | The following table sets forth the computation of the basic and diluted net loss per share (in thousands, except share and per share amounts): Three Months Ended Six Months Ended 2022 2021 2022 2021 Numerator: Net loss $ ( 11,872 ) $ ( 11,774 ) $ ( 23,635 ) $ ( 21,661 ) Denominator: Weighted-average shares of common stock outstanding 23,493,613 23,329,756 23,492,960 23,306,708 Net loss per share, basic and diluted $ ( 0.51 ) $ ( 0.50 ) $ ( 1.01 ) $ ( 0.93 ) |
Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share | Basic net loss per share was the same as diluted net loss per share for all periods as the inclusion of potentially dilutive securities would have been anti-dilutive. Potentially dilutive securities that were not included in the diluted per share calculations were as follows: June 30, 2022 2021 Shares subject to outstanding common stock options 3,954,980 2,612,963 Shares subject to outstanding RSUs 425,853 — Estimated shares issuable under the ESPP 138,365 32,255 Total 4,519,198 2,645,218 |
Organization and Principal Ac_2
Organization and Principal Activities - Additional Information (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | |||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021 | |
Organization And Principal Activities [Line Items] | |||||
Cash, cash equivalents and investments | $ 99,100 | $ 99,100 | |||
Net loss | (11,872) | $ (11,774) | (23,635) | $ (21,661) | |
Cash in operations | 21,400 | ||||
Accumulated deficit | $ (126,768) | $ (126,768) | $ (103,133) |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 | Jun. 30, 2021 |
Accounting Policies [Abstract] | |||
Cash and cash equivalents | $ 47,210 | $ 42,748 | $ 78,278 |
Restricted cash | 216 | 216 | |
Total cash, cash equivalents and restricted cash | $ 47,426 | $ 78,494 |
Cash Equivalents and Investme_3
Cash Equivalents and Investments - Summary of Amortized Cost, Unrealized Gains, and Losses, and Fair Value (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Schedule Of Available For Sale Securities [Line Items] | ||
Cash and cash equivalents and available for sale securities, amortized cost | $ 97,056 | $ 116,931 |
Cash and cash equivalents and available for sale securities, gross unrealized losses | (845) | (184) |
Cash and cash equivalents and available for sale securities, fair value | 96,210 | 116,747 |
Short Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 46,742 | 46,257 |
Available for sale, gross unrealized losses | (657) | (36) |
Available for sale, fair value | 46,085 | 46,221 |
Long Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 5,994 | 32,607 |
Available for sale, gross unrealized losses | (189) | (148) |
Available for sale, fair value | 5,805 | 32,459 |
Money Market Funds | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Cash and cash equivalents, amortized cost | 44,320 | 38,067 |
Cash and cash equivalents, fair value | 44,320 | 38,067 |
Cash And Cash Equivalents | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Cash and cash equivalents, amortized cost | 44,320 | 38,067 |
Cash and cash equivalents, fair value | 44,320 | 38,067 |
Commercial Paper | Short Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 33,973 | |
Available for sale, fair value | 33,973 | |
Corporate Bond | Short Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 14,662 | 6,285 |
Available for sale, gross unrealized losses | (191) | (23) |
Available for sale, fair value | 14,471 | 6,262 |
Corporate Bond | Long Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 8,470 | |
Available for sale, gross unrealized losses | (34) | |
Available for sale, fair value | 8,436 | |
US Treasury Securities | Short Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 32,080 | 5,999 |
Available for sale, gross unrealized losses | (466) | (13) |
Available for sale, fair value | 31,614 | 5,986 |
US Treasury Securities | Long Term Investments | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Available for sale, amortized cost | 5,994 | 24,137 |
Available for sale, gross unrealized losses | (189) | (114) |
Available for sale, fair value | $ 5,805 | $ 24,023 |
Cash Equivalents and Investme_4
Cash Equivalents and Investments - Additional Information (Details) - USD ($) | 6 Months Ended | |
Jun. 30, 2022 | Dec. 31, 2021 | |
Accrued interest on investments | $ 135,000 | $ 135,000 |
Weighted-average remaining contractual term maturities available for sale | 8 months | |
Debt securities, available-for-sale, realized gain (loss) | $ 0 | |
Debt securities, available-for-sale, Continuous unrealized loss position, 12 months or longer | 0 | |
Debt securities, available-for-sale, realized gain (loss), excluding other-than-temporary impairment | $ 0 | |
Cash equivalents and short term investments due term | 1 year |
Fair Value Measurements - Summa
Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Total cash equivalents and investments | $ 96,210 | $ 116,747 |
Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 46,085 | 46,221 |
Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 5,805 | 32,459 |
Money Market Funds | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Cash equivalents, fair value | 44,320 | 38,067 |
Commercial Paper | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 33,973 | |
Corporate Bond | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 14,471 | 6,262 |
Corporate Bond | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 8,436 | |
US Treasury Securities | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 31,614 | 5,986 |
US Treasury Securities | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 5,805 | 24,023 |
Fair Value Recurring | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Cash equivalents, fair value | 44,320 | 38,067 |
Total cash equivalents and investments | 96,210 | 116,747 |
Fair Value Recurring | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 46,085 | 46,221 |
Fair Value Recurring | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 5,805 | 32,459 |
Fair Value Recurring | Level 1 | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Cash equivalents, fair value | 44,320 | 38,067 |
Total cash equivalents and investments | 96,210 | 82,774 |
Fair Value Recurring | Level 1 | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 46,085 | 12,248 |
Fair Value Recurring | Level 1 | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 5,805 | 32,459 |
Fair Value Recurring | Level 2 | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Total cash equivalents and investments | 33,973 | |
Fair Value Recurring | Level 2 | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 33,973 | |
Fair Value Recurring | Money Market Funds | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Cash equivalents, fair value | 44,320 | 38,067 |
Fair Value Recurring | Money Market Funds | Level 1 | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Cash equivalents, fair value | 44,320 | 38,067 |
Fair Value Recurring | Commercial Paper | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 33,973 | |
Fair Value Recurring | Commercial Paper | Level 2 | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 33,973 | |
Fair Value Recurring | Corporate Bond | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 14,471 | 6,262 |
Fair Value Recurring | Corporate Bond | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 8,436 | |
Fair Value Recurring | Corporate Bond | Level 1 | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 14,471 | 6,262 |
Fair Value Recurring | Corporate Bond | Level 1 | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 8,436 | |
Fair Value Recurring | US Treasury Securities | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 31,614 | 5,986 |
Fair Value Recurring | US Treasury Securities | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 5,805 | 24,023 |
Fair Value Recurring | US Treasury Securities | Level 1 | Short Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | 31,614 | 5,986 |
Fair Value Recurring | US Treasury Securities | Level 1 | Long Term Investments | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Available for sale, fair value | $ 5,805 | $ 24,023 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Accrued interest on investments | $ 135 | $ 135 |
Estimated fair value of term loan | $ 4,700 |
Balance Sheet Components Additi
Balance Sheet Components Additional Information (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Balance Sheet Components Disclosure [Abstract] | ||||
Depreciation | $ 9 | $ 5 | $ 18 | $ 9 |
Balance Sheet Components - Sche
Balance Sheet Components - Schedule of Property and equipment (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Property, Plant and Equipment [Line Items] | ||
Less: accumulated depreciation | $ (49) | $ (31) |
Property and equipment, net | 127 | 140 |
Computer And Office Equipment [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 20 | 15 |
Software Development [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 27 | 27 |
Machinery And Equipment [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 58 | 58 |
Leasehold Improvements [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 7 | 7 |
Furniture And Fixtures [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | $ 64 | $ 64 |
Balance Sheet Components - Sc_2
Balance Sheet Components - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Balance Sheet Components Disclosure [Abstract] | ||
Accrued research and development expenses | $ 6,226 | $ 3,837 |
Accrued general and administrative expenses | 347 | 416 |
Lease liability, current portion | 380 | 360 |
Total accrued expenses and other current liabilities | $ 6,953 | $ 4,613 |
Leases - Additional Information
Leases - Additional Information (Details) - USD ($) $ in Millions | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||
Feb. 29, 2020 | Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Leases [Abstract] | |||||
Operating lease commencement date | 2020-09 | ||||
Operating lease term | 63 months | ||||
Operating leases, gross commitment | $ 2.3 | ||||
Operating Leases, option to renew lease term description | The lease includes an option to renew the lease term for an additional period of 60 months. The renewal option is not included in the lease term as the Company is not reasonably certain to exercise the option. | ||||
Operating leases, renew lease term | 60 months | ||||
Operating leases, lease expense | $ 0.1 | $ 0.1 | $ 0.2 | $ 0.2 | |
Weighted-average remaining lease term for operating leases | 3 years 4 months 24 days | 3 years 4 months 24 days | |||
weighted-average discount rate | 7% | 7% | |||
Cash paid for amounts included in measurement of lease liabilities | $ 0.1 | $ 0.1 | $ 0.2 | $ 0.1 |
Term Loan - Additional Informat
Term Loan - Additional Information (Details) | 1 Months Ended | 3 Months Ended | 6 Months Ended | |||||
Nov. 30, 2020 shares | Apr. 30, 2020 | Sep. 30, 2019 USD ($) $ / shares shares | Jun. 30, 2022 USD ($) Installment | Jun. 30, 2021 USD ($) | Jun. 30, 2022 USD ($) Installment | Jun. 30, 2021 USD ($) | May 31, 2022 USD ($) | |
Debt Instrument [Line Items] | ||||||||
Aggregate principal amount | $ 4,888,000 | $ 4,888,000 | ||||||
Silicon Valley Bank | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt liquidity covenant | If the Company does not comply with the foregoing liquidity covenant, a springing cash pledge will occur, pursuant to which the Company must maintain a cash secured blocked account with SVB with a cash balance in an amount equal to the outstanding SVB obligations at such time (excluding Bank Services (as defined in the Loan Agreement)). The foregoing cash collateral requirement will terminate upon a certain additional equity raise, which must occur on or before September 30, 2024. | |||||||
Liquidity covenant amount | Further, in the event that the Supplemental Term Loans under the Second Tranche become available and the Company obtains an advance thereunder, the Company will be required to comply with a new liquidity covenant of at least $50.0 million at all times. | |||||||
Term Loan | Silicon Valley Bank | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt instrument, extended term | 6 months | |||||||
Aggregate principal amount | $ 30,000,000 | $ 30,000,000 | ||||||
Debt instrument, maturity date | Jan. 01, 2026 | |||||||
Debt Instrument Frequency Of Periodic Payment | monthly | |||||||
Number of Monthly Installments | Installment | 37 | 37 | ||||||
End of term payment, percentage | 4% | |||||||
Debt issuance costs | $ 10,000 | $ 10,000 | ||||||
Unamortized debt issuance costs and debt discount | 100,000 | 100,000 | ||||||
Interest payments on debt | 57,000 | $ 43,000 | 110,000 | $ 97,000 | ||||
Term Loan | Silicon Valley Bank | The Second Amendment | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt issuance costs | 15,600 | $ 15,600 | ||||||
Term Loan | Silicon Valley Bank | Maximum | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt instrument prepayment fee percentage | 2% | |||||||
Term Loan | Silicon Valley Bank | Minimum | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt instrument prepayment fee percentage | 1% | |||||||
Term Loan | Silicon Valley Bank | Warrant | ||||||||
Debt Instrument [Line Items] | ||||||||
Number of shares issuable upon the exercise of warrant | shares | 49,609 | |||||||
Warrants exercise price | $ / shares | $ 1.44 | |||||||
Estimated fair value of the warrant | $ 100,000 | |||||||
Term Loan | Silicon Valley Bank | Common Stock | Warrant | ||||||||
Debt Instrument [Line Items] | ||||||||
Net exercised of common stock | shares | 46,358 | |||||||
First Tranche Term Loan | Silicon Valley Bank | ||||||||
Debt Instrument [Line Items] | ||||||||
Aggregate principal amount | 20,000,000 | $ 20,000,000 | ||||||
Repayment of outstanding obligations | $ 5,000,000 | |||||||
Debt instrument, maturity date | Dec. 31, 2021 | |||||||
End of term payment, percentage | 6% | |||||||
Outstanding interest rate | $ 5,000,000 | |||||||
Second Tranche Term Loan | Silicon Valley Bank | ||||||||
Debt Instrument [Line Items] | ||||||||
Aggregate principal amount | $ 10,000,000 | $ 10,000,000 | $ 10,000,000 | |||||
Debt instrument, maturity date | Dec. 31, 2022 | |||||||
Floating interest rate scenario one | 4.25% | |||||||
Debt instrument basis spread variable rate scenario two | 6.25% | |||||||
Number of Monthly Installments | Installment | 31 | 31 | ||||||
Second Tranche Term Loan | Silicon Valley Bank | Prime Rate | ||||||||
Debt Instrument [Line Items] | ||||||||
Floating interest scenario two | 3.75% | |||||||
Second Tranche Term Loan | Silicon Valley Bank | Prime Rate | Maximum | ||||||||
Debt Instrument [Line Items] | ||||||||
Debt instrument basis spread variable rate scenario one | 1% | |||||||
Debt instrument basis spread variable rate scenario two | 3% | |||||||
Floating interest scenario one | 0.50% |
Term Loan - Schedule of Term Lo
Term Loan - Schedule of Term Loan (Details) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Debt Disclosure [Abstract] | ||
Total Term Loan debt | $ 5,000 | |
Less: unamortized discount and debt issuance costs | (112) | |
Total Term Loan, net | 4,888 | |
Less: Term Loan, current portion | (811) | $ 0 |
Term loan, net of current portion | $ 4,077 | $ 4,878 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) | 6 Months Ended |
Jun. 30, 2022 USD ($) | |
Commitments And Contingencies Disclosure [Abstract] | |
Aggregate license agreement amount | $ 23,000,000 |
Additional aggregate license agreement amount | 0 |
Legal fees | $ 0 |
Capital Structure - Additional
Capital Structure - Additional Information (Details) - USD ($) | 6 Months Ended | ||
Jun. 30, 2022 | Feb. 28, 2022 | Dec. 31, 2021 | |
Class Of Stock [Line Items] | |||
Common stock shares authorized | 200,000,000 | 200,000,000 | |
Common stock par value per share | $ 0.0001 | $ 0.0001 | |
Common stockholders voting rights | one vote | ||
Common stock dividends declared | $ 0 | ||
Common stock, shares issued | 23,560,250 | 23,491,881 | |
Shelf Registration And Sales Agreement | |||
Class Of Stock [Line Items] | |||
Maximum amount of sale covered in shelf registration statement | $ 200,000,000 | ||
Shelf Registration And Sales Agreement | Jefferies LLC | |||
Class Of Stock [Line Items] | |||
Maximum amount of offering issuance and sale covered in sales agreement | $ 21,000,000 | ||
Redeemable Convertible Preferred Stock | |||
Class Of Stock [Line Items] | |||
Common stock, shares issued | 0 |
Capital Structure - Summary of
Capital Structure - Summary of Common Stock Reserved for Future Issuance (Details) - shares | Jun. 30, 2022 | Dec. 31, 2021 |
Class Of Stock [Line Items] | ||
Shares reserved for future issuance | 7,838,681 | 5,745,648 |
Employee Stock Purchase Plan, Available for Future Issuance | ||
Class Of Stock [Line Items] | ||
Shares reserved for future issuance | 642,573 | 433,200 |
Stock Options, Issued and Outstanding | ||
Class Of Stock [Line Items] | ||
Shares reserved for future issuance | 3,954,980 | 2,215,942 |
Restricted and Performance Stock Units, Issued and Outstanding [Member] | ||
Class Of Stock [Line Items] | ||
Shares reserved for future issuance | 425,853 | 460,000 |
Shares available for future issuance under 2020 Equity Incentive Plan | ||
Class Of Stock [Line Items] | ||
Shares reserved for future issuance | 2,815,275 | 2,636,506 |
Equity Incentive Plans and St_3
Equity Incentive Plans and Stock-Based Compensation Expense - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended | |
Oct. 31, 2020 | Jun. 30, 2022 | Jun. 30, 2022 | Dec. 31, 2021 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares reserved for issuance | 7,838,681 | 7,838,681 | 5,745,648 | |
Equity incentive plan, terms | No further grants will be made under the 2016 Plan; however, shares subject to awards granted under the 2016 Plan will continue to be governed by the 2016 Plan. | |||
Number of shares early exercised under any plan | 0 | 0 | ||
Aggregate intrinsic value of options exercised | $ 0 | $ 1,000 | ||
Weighted-average fair value of options granted | $ 1.47 | $ 2.56 | ||
Unrecognized stock-based compensation expense | $ 7,400,000 | $ 7,400,000 | ||
Unrecognized stock-based compensation expense expected to be recognized over weighted-average vesting term | 2 years 10 months 24 days | |||
RSU | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares, Granted | 92,200 | |||
Unrecognized stock-based compensation expense | $ 600,000 | $ 600,000 | ||
Unrecognized stock-based compensation expense expected to be recognized over weighted-average vesting term | 1 year 3 months 18 days | |||
RSU | Share Based Compensation Award Tranche Three Member | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares, Granted | 68,775 | |||
RSU | Share Based Compensation Award Tranche Four Member | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares, Granted | 23,425 | |||
2020 Equity Incentive Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares reserved for issuance | 2,647,684 | |||
Equity incentive plan, terms | In addition, the number of shares of common stock available for issuance under the 2020 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2020 Plan, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to 5% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year or such lesser amount as determined by the Company’s Board of Directors. | |||
Shares authorized for issuance | 4,985,297 | 4,985,297 | ||
Shares remained available for issuance | 2,815,275 | 2,815,275 | ||
Term of automatically increase in common stock available for issuance | 10 years | |||
Percentage of outstanding shares subject to automatic increase in common stock | 5% | |||
2016 Equity Incentive Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares authorized for issuance | 1,275,158 | 1,275,158 | ||
Shares remained available for issuance | 0 | 0 | ||
2020 Employee Stock Purchase Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Shares reserved for issuance | 220,640 | |||
Equity incentive plan, terms | In addition, the number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten-years of the term of the ESPP, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to the lesser of (i) 1% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year, (ii) 441,280 shares of common stock or (iii) such lesser amount as determined by the Board of Directors. | |||
Shares remained available for issuance | 441,280 | 642,573 | 642,573 | |
ESPP issued | 25,545 | |||
Maximum percentage of compensation that an employee is allowed to purchase shares | 15% | |||
Purchase price of common stock expressed as a percentage of fair market value | 85% | |||
Term of automatically increase in common stock available for issuance | 10 years | |||
Percentage of outstanding shares subject to automatic increase in common stock | 1% |
Equity Incentive Plans and St_4
Equity Incentive Plans and Stock-Based Compensation Expense - Summary of Stock Option Activity (Details) - 2020 Equity Incentive Plan - USD ($) $ / shares in Units, $ in Thousands | 6 Months Ended | 12 Months Ended |
Jun. 30, 2022 | Dec. 31, 2021 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Beginning Balance, Outstanding Stock Options | 2,215,942 | |
Granted, Outstanding Stock Options | 2,143,125 | |
Exercised, Outstanding Stock Options | (992) | |
Forfeited, Outstanding Stock Options | (403,095) | |
Ending Balance, Outstanding Stock Options | 3,954,980 | 2,215,942 |
Vested and expected to vest, Outstanding Stock Options | 3,814,980 | |
Vested and exercisable, Outstanding Stock Options | 1,461,195 | |
Weighted Average Grant Date Fair Value Per Share, Beginning Balance | $ 4.72 | |
Granted, Weighted-Average Exercise Price | 3.23 | |
Exercised, Weighted-Average Exercise Price | 1.39 | |
Forfeited, Weighted-Average Exercise Price | 7.47 | |
Ending Balance, Weighted-Average Exercise Price | 3.63 | $ 4.72 |
Vested and expected to vest, Weighted-Average Exercise Price | 3.59 | |
Vested and exercisable, Weighted-Average Exercise Price | $ 3.57 | |
Weighted-Average Remaining Contractual Life (Years) | 8 years 1 month 6 days | 6 years 10 months 24 days |
Vested and expected to vest, Weighted-Average Remaining Contractual Life (Years) | 8 years | |
Vested and exercisable, Weighted-Average Remaining Contractual Life (Years) | 5 years 4 months 24 days | |
Aggregate Intrinsic Value | $ 410 | $ 3,959 |
Vested and expected to vest, Aggregate Intrinsic Value | 410 | |
Vested and exercisable, Aggregate Intrinsic Value | $ 292 |
Equity Incentive Plans and St_5
Equity Incentive Plans and Stock-Based Compensation Expense - Summary of RSU Activity (Details) - RSU | 6 Months Ended |
Jun. 30, 2022 $ / shares shares | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |
Shares, Unvested, Beginning Balance | shares | 460,000 |
Shares, Granted | shares | 92,200 |
Shares, Vested | shares | (64,347) |
Shares, Forfeited | shares | (62,000) |
Shares, Unvested, Ending Balance | shares | 425,853 |
Weighted Average Grant Date Fair Value Per Share, Beginning Balance | $ / shares | $ 2.48 |
Weighted Average Grant Date Fair Value Per Share, Granted | $ / shares | 2.58 |
Weighted Average Grant Date Fair Value Per Share, Vested | $ / shares | 2.49 |
Weighted Average Grant Date Fair Value Per Share, Forfeited | $ / shares | 2.55 |
Weighted Average Grant Date Fair Value Per Share, Ending Balance | $ / shares | $ 2.49 |
Equity Incentive Plans and St_6
Equity Incentive Plans and Stock-Based Compensation Expense - Summary of Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||||
Total stock-based compensation expense | $ 905 | $ 1,010 | $ 2,046 | $ 2,130 |
Research and Development | ||||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||||
Total stock-based compensation expense | 245 | 346 | 545 | 610 |
General and Administrative | ||||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||||
Total stock-based compensation expense | $ 660 | $ 664 | $ 1,501 | $ 1,520 |
Net Loss Per Share - Schedule o
Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Numerator: | ||||
Net loss | $ (11,872) | $ (11,774) | $ (23,635) | $ (21,661) |
Denominator: | ||||
Weighted-average shares of common stock outstanding | 23,493,613 | 23,329,756 | 23,492,960 | 23,306,708 |
Net loss per share, basic and diluted | $ (0.51) | $ (0.50) | $ (1.01) | $ (0.93) |
Net Loss Per Share - Schedule_2
Net Loss Per Share - Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share (Details) - shares | 6 Months Ended | |
Jun. 30, 2022 | Jun. 30, 2021 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Potential dilutive securities excluded from diluted net loss per share | 4,519,198 | 2,645,218 |
Shares Subject to Outstanding Common Stock Options | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Potential dilutive securities excluded from diluted net loss per share | 3,954,980 | 2,612,963 |
Shares Subject To Outstanding Restricted Stock Units | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Potential dilutive securities excluded from diluted net loss per share | 425,853 | 0 |
Estimated Shares Issuable Under ESPP | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Potential dilutive securities excluded from diluted net loss per share | 138,365 | 32,255 |