Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2023 | Aug. 08, 2023 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Jun. 30, 2023 | |
Document Fiscal Year Focus | 2023 | |
Document Fiscal Period Focus | Q2 | |
Trading Symbol | SLDB | |
Entity Registrant Name | Solid Biosciences Inc. | |
Entity Current Reporting Status | Yes | |
Entity Central Index Key | 0001707502 | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Non-accelerated Filer | |
Entity Shell Company | false | |
Entity Small Business | true | |
Entity Emerging Growth Company | true | |
Entity Ex Transition Period | true | |
Entity Common Stock, Shares Outstanding | 20,060,039 | |
Entity File Number | 001-38360 | |
Entity Tax Identification Number | 90-0943402 | |
Entity Address, Address Line One | 500 Rutherford Avenue | |
Entity Address, City or Town | Third FloorCharlestown | |
Entity Address, State or Province | MA | |
Entity Address, Postal Zip Code | 02129 | |
City Area Code | 617 | |
Local Phone Number | 337-4680 | |
Entity Interactive Data Current | Yes | |
Title of 12(b) Security | Common Stock $0.001 par value per share | |
Security Exchange Name | NASDAQ | |
Entity Incorporation, State or Country Code | DE | |
Document Quarterly Report | true | |
Document Transition Report | false |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Current assets: | ||
Cash and cash equivalents | $ 91,569 | $ 155,384 |
Available-for-sale securities | 68,623 | 58,338 |
Prepaid expenses and other current assets | 7,283 | 5,916 |
Total current assets | 167,475 | 219,638 |
Operating lease, right-of-use assets | 27,841 | 28,949 |
Property and equipment, net | 7,391 | 9,657 |
Other non-current assets | 181 | 175 |
Restricted cash | 1,833 | 1,833 |
Total assets | 204,721 | 260,252 |
Current liabilities: | ||
Accounts payable | 2,968 | 3,238 |
Accrued expenses | 10,509 | 16,691 |
Operating lease liabilities | 1,853 | 1,897 |
Finance liabilities and finance lease liabilities | 419 | 668 |
Other current liabilities | 117 | 14 |
Total current liabilities | 15,866 | 22,508 |
Operating lease liabilities, excluding current portion | 23,645 | 24,279 |
Finance liabilities and finance lease liabilities, excluding current portion | 1,482 | 1,703 |
Other non-current liabilities | 96 | |
Total liabilities | 40,993 | 48,586 |
Commitments and contingencies (Note 13) | ||
Preferred stock, $0.001 par value; 10,000,000 shares authorizedat June 30, 2023 and December 31, 2022; no shares issued and outstanding at June 30, 2023 and December 31, 2022 | ||
Common stock, $0.001 par value; 60,000,000 shares authorized at June 30, 2023 and December 31, 2022; 20,044,389 shares issued and outstanding at June 30, 2023 and 19,556,732 shares issued and outstanding at December 31, 2022 | 20 | 20 |
Additional paid-in capital | 781,131 | 774,452 |
Accumulated other comprehensive income (loss) | 14 | (68) |
Accumulated deficit | (617,437) | (562,738) |
Total stockholders’ equity | 163,728 | 211,666 |
Total liabilities and stockholders’ equity | $ 204,721 | $ 260,252 |
Condensed Consolidated Balanc_2
Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares | Jun. 30, 2023 | Dec. 31, 2022 |
Statement of Financial Position [Abstract] | ||
Preferred stock, par value | $ 0.001 | $ 0.001 |
Preferred stock, shares authorized | 10,000,000 | 10,000,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 60,000,000 | 60,000,000 |
Common stock, shares issued | 20,044,389 | 19,556,732 |
Common stock, shares outstanding | 20,044,389 | 19,556,732 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | |
Operating expenses: | ||||
Research and development | $ 19,777 | $ 23,180 | $ 44,408 | $ 43,125 |
General and administrative | 7,129 | 6,851 | 14,528 | 14,203 |
Restructuring Charges | (63) | 1,520 | (63) | 1,520 |
Total operating expenses | 26,843 | 31,551 | 58,873 | 58,848 |
Loss from operations | (26,843) | (25,382) | (58,873) | (50,754) |
Other income, net: | ||||
Interest income, net | 1,949 | 293 | 3,627 | 347 |
Other income (expense), net | 265 | (3) | 547 | (13) |
Total other income, net | 2,214 | 290 | 4,174 | 334 |
Net loss | $ (24,629) | $ (25,092) | $ (54,699) | $ (50,420) |
Net loss per share attributable to common stockholders, basic | $ (1.25) | $ (3.33) | $ (2.79) | $ (6.71) |
Net loss per share attributable to common stockholders, diluted | $ (1.25) | $ (3.33) | $ (2.79) | $ (6.71) |
Weighted average shares of common stock outstanding, basic | 19,663,672 | 7,523,964 | 19,618,517 | 7,515,673 |
Weighted average shares of common stock outstanding, diluted | 19,663,672 | 7,523,964 | 19,618,517 | 7,515,673 |
Related Party [Member] | ||||
Collaboration revenue - related party | $ 6,169 | $ 8,094 |
Condensed Consolidated Statem_2
Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | |
Statement of Comprehensive Income [Abstract] | ||||
Net loss | $ (24,629) | $ (25,092) | $ (54,699) | $ (50,420) |
Other comprehensive loss: | ||||
Unrealized gain (loss) on available-for-sale securities | 9 | (71) | 82 | (77) |
Comprehensive loss | $ (24,620) | $ (25,163) | $ (54,617) | $ (50,497) |
Condensed Consolidated Statem_3
Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid in Capital [Member] | Accumulated Other Comprehensive Income (Loss) [Member] | Accumulated Deficit [Member] |
Beginning balance at Dec. 31, 2021 | $ 208,211 | $ 7 | $ 685,006 | $ (45) | $ (476,757) |
Beginning balance, units at Dec. 31, 2021 | 7,499,905 | ||||
Equity-based compensation | 4,426 | 4,426 | |||
Exercise of pre-funded warrants | 22 | 22 | |||
Vesting of restricted stock, units | 20,885 | ||||
Issuance of common stock in connection with employee stock purchase plan | 73 | 73 | |||
Issuance of common stock in connection with employee stock purchase plan, units | 10,190 | ||||
Unrealized gain (loss) on available-for-sale securities | (77) | (77) | |||
Net loss | (50,420) | (50,420) | |||
Ending balance at Jun. 30, 2022 | 162,235 | $ 7 | 689,527 | (122) | (527,177) |
Ending balance, units at Jun. 30, 2022 | 7,530,980 | ||||
Beginning balance at Mar. 31, 2022 | 185,511 | $ 7 | 687,640 | (51) | (502,085) |
Beginning balance, units at Mar. 31, 2022 | 7,518,753 | ||||
Equity-based compensation | 1,814 | 1,814 | |||
Vesting of restricted stock, units | 2,038 | ||||
Issuance of common stock in connection with employee stock purchase plan | 73 | 73 | |||
Issuance of common stock in connection with employee stock purchase plan, units | 10,189 | ||||
Unrealized gain (loss) on available-for-sale securities | (71) | (71) | |||
Net loss | (25,092) | (25,092) | |||
Ending balance at Jun. 30, 2022 | 162,235 | $ 7 | 689,527 | (122) | (527,177) |
Ending balance, units at Jun. 30, 2022 | 7,530,980 | ||||
Beginning balance at Dec. 31, 2022 | 211,666 | $ 20 | 774,452 | (68) | (562,738) |
Beginning balance, units at Dec. 31, 2022 | 19,556,732 | ||||
Equity-based compensation | 4,062 | 4,062 | |||
Vesting of restricted stock, units | 52,721 | ||||
Sales of common stock, net of issuance costs | 2,539 | 2,539 | |||
Sales of common stock, net of issuance costs, units | 420,000 | ||||
Issuance of common stock in connection with employee stock purchase plan | 78 | 78 | |||
Issuance of common stock in connection with employee stock purchase plan, units | 14,936 | ||||
Unrealized gain (loss) on available-for-sale securities | 82 | 82 | |||
Net loss | (54,699) | (54,699) | |||
Ending balance at Jun. 30, 2023 | 163,728 | $ 20 | 781,131 | 14 | (617,437) |
Ending balance, units at Jun. 30, 2023 | 20,044,389 | ||||
Beginning balance at Mar. 31, 2023 | 183,787 | $ 20 | 776,570 | 5 | (592,808) |
Beginning balance, units at Mar. 31, 2023 | 19,573,132 | ||||
Equity-based compensation | 1,944 | 1,944 | |||
Vesting of restricted stock, units | 36,321 | ||||
Sales of common stock, net of issuance costs | 2,539 | 2,539 | |||
Sales of common stock, net of issuance costs, units | 420,000 | ||||
Issuance of common stock in connection with employee stock purchase plan | 78 | 78 | |||
Issuance of common stock in connection with employee stock purchase plan, units | 14,936 | ||||
Unrealized gain (loss) on available-for-sale securities | 9 | 9 | |||
Net loss | (24,629) | (24,629) | |||
Ending balance at Jun. 30, 2023 | $ 163,728 | $ 20 | $ 781,131 | $ 14 | $ (617,437) |
Ending balance, units at Jun. 30, 2023 | 20,044,389 |
Condensed Consolidated Statem_4
Condensed Consolidated Statements of Changes in Stockholders' Equity (Parenthetical) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
Jun. 30, 2023 | Jun. 30, 2023 | |
Statement of Stockholders' Equity [Abstract] | ||
Issuance costs | $ 65 | $ 65 |
Condensed Consolidated Statem_5
Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2023 | Jun. 30, 2022 | |
Cash flows from operating activities: | ||
Net loss | $ (54,699) | $ (50,420) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Amortization of (discount) premium on available-for-sale securities | (273) | 526 |
Equity-based compensation expense | 4,062 | 4,426 |
Depreciation and impairment expense | 1,780 | 1,431 |
Gain on termination of lease | (249) | |
Changes in operating assets and liabilities: | ||
Prepaid expenses and other current and non-current assets | 962 | 586 |
Accounts receivable - related party | 110 | |
Accounts payable | 31 | 373 |
Accrued expenses and other current and non-current liabilities | (7,323) | 8,229 |
Deferred revenue- related party, current and non-current | (8,080) | |
Net cash used in operating activities | (55,460) | (43,068) |
Cash flows from investing activities: | ||
Purchases of property and equipment | (1,042) | (1,320) |
Proceeds from sale and maturities of available-for-sale securities | 58,632 | 92,156 |
Purchases of available-for-sale securities | (68,562) | (112,688) |
Net cash used in investing activities | (10,972) | (21,852) |
Cash flows from financing activities: | ||
Proceeds from issuance of common stock, net of issuance costs | 2,539 | |
Proceeds from exercise of warrants | 22 | |
Employee stock purchases and withholdings | 78 | 73 |
Net cash provided by financing activities | 2,617 | 95 |
Net decrease in cash, cash equivalents and restricted cash | (63,815) | (64,825) |
Cash, cash equivalents, and restricted cash at beginning of period | 157,217 | 121,206 |
Cash, cash equivalents, and restricted cash at end of period | 93,402 | 56,381 |
Supplemental disclosure of non-cash investing and financing activities: | ||
Right-of-use assets obtained in exchange for operating lease liabilities | 417 | 29,126 |
Decrease in right-of-use asset due to lease termination | (252) | (464) |
Decrease in property plant and equipment due to asset exchange | (950) | |
Property and equipment included in accounts payable and accruals | $ 141 | $ 600 |
Nature of the Business and Basi
Nature of the Business and Basis of Presentation | 6 Months Ended |
Jun. 30, 2023 | |
Accounting Policies [Abstract] | |
Nature of the Business and Basis of Presentation | 1. Nature of the Business and Basis of Presentation Nature of Business Solid Biosciences Inc. was organized in March 2013 under the name SOLID Ventures Management, LLC and operated as a Delaware limited liability company until immediately prior to the effectiveness of its registration statement on Form S-1 on January 25, 2018, at which time it completed a statutory corporate conversion into a Delaware corporation and changed its name to Solid Biosciences Inc. (the “Company”). On December 2, 2022, the Company completed its acquisition of AavantiBio, Inc. (“AavantiBio”), a privately held gene therapy company focused on transforming the lives of patients with Friedreich’s ataxia ("FA") and rare cardiomyopathies (the “Acquisition”). Upon the consummation of the Acquisition, the Company acquired AavantiBio’s candidates, AVB-202-TT and AVB-401, as well as additional assets for the treatment of undisclosed cardiac diseases, platform technologies and know-how related thereto. AavantiBio is a wholly owned subsidiary of the Company. The Company is a life sciences company focused on advancing a portfolio of neuromuscular and cardiac programs, including SGT-003, a differentiated gene therapy candidate, for the treatment of Duchenne muscular dystrophy ("Duchenne"); AVB-202-TT, a gene therapy program for the treatment of FA; AVB-401, a gene therapy program for the treatment of BAG3-mediated dilated cardiomyopathy; and additional assets for the treatment of undisclosed cardiac diseases. The Company aims to be a center of excellence, bringing together those with expertise in science, technology, disease management and care. Patient-focused and founded by those directly impacted by Duchenne, the Company's mandate is to improve the daily lives of patients living with these devastating diseases. The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development by competitors of new technological innovations, dependence on licenses, protection of proprietary technology, dependence on key personnel, compliance with government regulations and the need to obtain additional financing to fund operations. Product candidates currently under development will require significant additional research and development efforts, including extensive preclinical studies and clinical trials and regulatory approval, prior to commercialization. These efforts require significant amounts of additional capital, adequate personnel infrastructure and extensive compliance and reporting capabilities. The Company’s candidates are in development. There can be no assurance that the Company’s research and development will be successfully completed, that adequate protection for the Company’s intellectual property will be obtained, that any products developed will obtain necessary government regulatory approval or that any approved products will be commercially viable. Even if the Company’s product development efforts are successful, it is uncertain when, if ever, the Company will generate significant revenue from product sales. The Company operates in an environment of rapid change in technology and substantial competition from, among others, other pharmaceutical and biotechnology companies. In addition, the Company is dependent upon the services of its employees, partners and consultants. On October 27, 2022, the Company effected a reverse stock split of its outstanding shares of common stock at a ratio of one-for- 15 pursuant to a certificate of amendment to its certificate of incorporation filed with the Secretary of State of the State of Delaware. The reverse stock split was reflected on the Nasdaq Stock Market ("Nasdaq") beginning with the opening of trading on October 28, 2022. Pursuant to the reverse stock split, every 15 shares of the Company's issued and outstanding shares of common stock were automatically combined into one issued and outstanding share of common stock, without any change in the par value per share of the common stock. The reverse stock split reduced the authorized number of shares of common stock from 300,000,000 to 20,000,000 and, pursuant to the certificate of amendment, such reduced authorized number of shares of common stock was subsequently multiplied by three, such that following the reverse stock split the Company has 60,000,000 shares of common stock authorized. The reverse stock split affected all issued and outstanding shares of the Company's common stock, and the respective numbers of shares of common stock underlying the Company’s outstanding stock options, outstanding restricted stock units, outstanding warrants and the Company's equity incentive plans were proportionately adjusted. All share and per share amounts of the common stock included in the accompanying condensed consolidated financial statements have been retrospectively adjusted to give effect to the reverse stock split for all periods presented, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Basis of Presentation The accompanying condensed consolidated financial statements have been prepared on a basis that assumes the Company will continue as a going concern and which contemplates the realization of assets and satisfaction of liabilities and commitments in the ordinary course of business. Through June 30, 2023, the Company has funded its operations primarily with the proceeds from the sale of redeemable preferred units and member units as well as the sale of common stock and prefunded warrants to purchase shares of its common stock in private placements and the sale of common stock in its initial public offering, follow-on public offering in March 2021 and under its at-the-market sales agreement. On September 29, 2022, the Company entered into a securities purchase agreement, pursuant to which, on December 2, 2022, the Company issued an aggregate of 10,638,290 shares of the Company’s common stock in a private placement. The private placement closed immediately following the closing of the Acquisition on December 2, 2022. The Company received net proceeds from the private placement of $ 72,551 . During the three months ended June 30, 2023, the Company issued and sold 420,000 shares of its common stock pursuant to the Company's "at-the-market-offering" sales agreement, between us and Jefferies LLC, or Jefferies, or the ATM Sales Agreement. The Company receive net proceeds of $ 2,539 . In accordance with Accounting Standards Codification (“ASC”) 205-40, Going Concern, the Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the financial statements are issued. As of June 30, 2023, the Company had an accumulated deficit of $ 617,437 . During the three and six months ended June 30, 2023, the Company incurred a net loss of $ 24,629 and $ 54,699 , respectively, and the Company used $ 55,460 of cash in operations for the six months ended June 30, 2023. The Company expects to continue to generate operating losses in the foreseeable future. Based upon its current operating plan, the Company expects that its cash, cash equivalents and available-for-sale securities of $ 160,192 , excluding restricted cash of $ 1,833 , as of June 30, 2023, will be sufficient to fund its operating expenses and capital expenditure requirements for at least twelve months from the date of issuance of these financial statements. However, the Company has based this estimate on assumptions that may prove to be wrong, and its operating plan may change as a result of many factors currently unknown to it. As a result, the Company could deplete its capital resources sooner than it currently expects. The Company expects to finance its future cash needs through a combination of equity offerings, debt financings, collaborations, strategic alliances or licensing arrangements. If the Company is unable to obtain funding, the Company would be forced to delay, reduce or eliminate some or all of its research and development programs, preclinical and clinical testing or commercialization efforts, which could adversely affect its business prospects. The accompanying condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”). The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly owned or controlled subsidiaries. All intercompany accounts and transactions have been eliminated. In the opinion of management, the Company’s accompanying unaudited condensed consolidated financial statements include all adjustments, consisting of normal recurring accruals, necessary for a fair statement of the Company’s financial statements for interim periods in accordance with GAAP. The information included in this quarterly report on Form 10-Q should be read in conjunction with the Company’s consolidated financial statements and the accompanying notes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. The year-end condensed consolidated balance sheet data presented for comparative purposes was derived from the Company’s audited financial statements but does not include all disclosures required by GAAP. The results of operations for the three and six months ended June 30, 2023 are not necessarily indicative of the operating results for the full year or for any other subsequent interim period. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2023 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies The Company’s accounting policies are described in the “Notes to Consolidated Financial Statements” in its Annual Report on Form 10-K for the year ended December 31, 2022 and updated, as necessary, in this report. Use of Estimates The preparation of the Company’s condensed consolidated financial statements in conformity with GAAP requires management to make estimates, judgments and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, estimates related to revenue recognition, the recognition of research and development expenses and equity-based compensation. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from the Company’s estimates. The Company has made estimates of the impact of the recent COVID-19 pandemic within its financial statements and there may be changes to those estimates in future periods. Actual results could differ from the Company’s estimates. Cash Equivalents The Company considers all short-term, highly liquid investments with original maturities of 90 days or less at acquisition date to be cash equivalents. Restricted Cash The Company held restricted cash of $ 1,833 in a restricted bank account as a security deposit for a lease of the Company’s facilities as of June 30, 2023 and December 31, 2022. The Company has included restricted cash of $ 1,833 classified as non-current assets as of June 30, 2023 and December 31, 2022. A reconciliation of the amounts of cash and cash equivalents and restricted cash from the cash flow statement to the balance sheet is as follows: June 30, December 31, June 30, December 31, Cash and cash equivalents as presented on balance sheet $ 91,569 $ 155,384 $ 54,311 $ 119,136 Restricted cash, current, as presented on balance sheet — — 237 — Restricted cash, non-current, as presented on balance sheet 1,833 1,833 1,833 2,070 Cash and cash equivalents and restricted cash as presented on $ 93,402 $ 157,217 $ 56,381 $ 121,206 Leases The Company has operating leases for laboratory and office space in Massachusetts, North Carolina and Florida. In June 2021, the Company entered into a lease with Hood Park LLC (“Landlord”), pursuant to which the Company leases approximately 49,869 square feet of office, laboratory, research and development and manufacturing space located in Charlestown, Massachusetts (“Premises”). The Company relocated its corporate headquarters to the Premises in June 2022. The initial term of the lease commenced in June 2022 when the construction of the lessor assets was substantially completed and continues for a ten-year period, unless earlier terminated. The lease provides the Company with an option to extend the lease for an additional five-year term. The Company and the Landlord were each obligated to undertake certain improvements prior to the commencement of the lease, and significant improvements were completed as of June 2022. The monthly lease payment is approximately $ 305 with annual escalation of approximately 3 %. The lease includes a $ 10,223 construction allowance. The Company was required to post a customary letter of credit in the amount of $ 1,833 , subject to decrease on a set schedule, as a security deposit pursuant to the lease. During the year ended December 31, 2022, the Company recorded a failed sales-leaseback transaction related to certain lab equipment. The related financing liabilities are recorded on the Company's consolidated balance sheets within financing labilities. In connection with this transaction, the Company also recorded a cash inflow within financing activities under proceeds from financing liabilities of $ 2,143 . Segment Data The Company manages its operations as a single segment for the purposes of assessing performance and making operating decisions. The Company’s singular focus is on developing treatments through gene therapy and other means for patients with neuromuscular and cardiac diseases. All of the Company’s tangible assets are held in the United States. |
License and Research Agreements
License and Research Agreements | 6 Months Ended |
Jun. 30, 2023 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
License and Research Agreements | 3. License and Research Agreements Ultragenyx Collaboration Collaboration Agreement On October 22, 2020 (the “Effective Date”), the Company entered into the Collaboration Agreement with Ultragenyx to focus on the development and commercialization of new gene therapies for Duchenne. The Company granted Ultragenyx an exclusive worldwide license for any pharmaceutical product that expresses the Company’s proprietary microdystrophin construct from AAV8 and variants thereof in clade E for the treatment of Duchenne and other diseases resulting from the lack of functional dystrophin (the “Licensed Products”). The Company retains exclusive rights to all other uses of its microdystrophin proteins, including under its SGT-001 and SGT-003 programs. The Company has conducted certain research and development activities with respect to the development of the Licensed Products, and concluded such activities as were contemplated under the Collaboration Agreement during the second quarter of 2022, resulting in the recognition of the remaining deferred revenue recorded at the time the Collaboration Agreement was executed, related to the upfront payment received from Ultragenyx. The Company may conduct additional research and development activities in collaboration with Ultragenyx from time to time in the future. Ultragenyx reimbursed the Company for personnel and out-of-pocket costs that the Company incurred in conducting such activities. In addition, the Company is entitled to certain milestone payments, royalties and profit sharing for each Licensed Product dependent on the Company's election to exercise a Development Option or Income Share Options as defined in the Collaboration Agreement. The Collaboration Agreement continues on a country-by-country and Licensed Product-by-Licensed Product basis until the expiration of all payment obligations under the agreement. With respect to any Licensed Product for which the Company has exercised an Income Share Option, the Collaboration Agreement continues until there are no longer sales of such Licensed Product in the United States or Europe. Either party has the right to terminate the agreement if the other party has materially breached in the performance of its obligations under the agreement and such breach has not been cured within the applicable cure period. Ultragenyx may also terminate the Collaboration Agreement in its sole discretion upon 90 days’ prior written notice to the Company. Stock Purchase Agreement In connection with the execution of the Collaboration Agreement, Ultragenyx and the Company also entered into a stock purchase agreement (the “Stock Purchase Agreement”) on the Effective Date, pursuant to which the Company issued and sold 521,719 shares of its common stock (the “Shares”) to Ultragenyx at a price of $ 76.6695 per share for an aggregate purchase price of approximately $ 40,000 . The Stock Purchase Agreement contains customary representations, warranties and covenants of each of the parties thereto. Following the sale of the Shares, Ultragenyx beneficially owned approximately 14.45 % of the Company’s outstanding common stock. As of June 30, 2023 , Ultragenyx beneficially owned approximately 2.6 % of the Company’s outstanding common stock. Investor Agreement In connection with the consummation of the transactions contemplated by the Stock Purchase Agreement, the Company and Ultragenyx entered into an Investor Agreement (the “Investor Agreement”) on the Effective Date. Pursuant to the terms of the Investor Agreement, Ultragenyx agreed that, so long as it holds at least 10 % of the Company’s outstanding common stock, the Shares will be subject to a voting agreement, such that until the earliest to occur of certain specified events, and subject to specified conditions, Ultragenyx will, and will cause its permitted transferees to, vote in accordance with the recommendation of the Company’s Board of Directors with respect to specified matters. Accounting Treatment The Company concluded that the Collaboration Agreement and the Stock Purchase Agreement should be combined and treated as a single arrangement for accounting purposes as the agreements were entered into contemporaneously and in contemplation of one another. The Company assessed this arrangement in accordance with ASC 606 and concluded that the contract counterparty, Ultragenyx, is a customer. The Company identified the following promises in the Collaboration Agreement that were evaluated under the scope of ASC 606: (1) an exclusive worldwide license to the Licensed Products; (2) an obligation to perform research and development services; and (3) an obligation to participate in a joint steering committee. The Company assessed the promised goods and services to determine if they are distinct. Based on this assessment, the Company determined that Ultragenyx cannot benefit from the promised goods and services separately from the others as they are highly interrelated and therefore not distinct. Due to the early stage of the Licensed Products, the research and development services could not be performed by another party. The Company’s skill-set, knowledge and expertise are required to conduct the research and development services and the research and development services are expected to involve significant further development of the Licensed Products. Accordingly, the promised goods and services represent one combined performance obligation and the entire transaction price will be allocated to that single combined performance obligation. The Company determined the transaction price under ASC 606 at the inception of the Collaboration Agreement to be $ 22,513 , which represents the excess proceeds from the equity investment under the Stock Purchase Agreement, when measured at fair value after taking into consideration a discount for lack of marketability, plus the estimated reimbursement of research and development costs, which represents variable consideration. The Company included the estimated reimbursement of research and development costs in the transaction price at the inception of the arrangement because the Company is required to perform research and development services and the contract requires Ultragenyx to reimburse the Company for costs incurred. Also, since the related revenue would be recognized only as the costs are incurred, the Company determined it is not probable that a significant reversal of cumulative revenue would occur. The Company evaluated how much variable consideration related to development and regulatory milestones, and the Company’s potential exercise of its Development Option or Income Share Option per Licensed Product, to include in the transaction price using the most likely amount approach and concluded that no amount should be included in the transaction price due to the high degree of uncertainty and risk associated with these potential payments. The Company also determined that royalties and sales milestones relate solely to the license of intellectual property and are therefore excluded from the transaction price under the sales- or usage-based royalty exception of ASC 606. Revenue related to these royalties and sales milestones will only be recognized when the associated sales occur, and relevant thresholds are met. The Company determined that revenue under the Collaboration Agreement should be recognized over time as Ultragenyx simultaneously receives the benefit from the Company as the Company performs under the single performance obligation over time. The Company will recognize revenue for the single performance obligation using a cost-to-cost input method as the Company has concluded it best depicts the research and development and joint steering committee participation services performed. Under this method, the transaction price is recognized over the contract’s entire performance period, using costs incurred relative to total estimated costs to determine the extent of progress towards completion. During the three and six months ended June 30, 2023, the Company did no t recognize any related party collaboration revenue associated with its collaboration with Ultragenyx. During the three and six months ended June 30, 2022, the Company recognized $ 6,169 and $ 8,094 , respectively, of related party collaboration revenue. As of June 30, 2023 and December 31, 2022, there was $ 0 of deferred revenue related to the Collaboration Agreement. Additionally, as of June 30, 2023 and December 31, 2022, there was $ 0 of related party collaboration receivables related to reimbursable costs expected to be received from Ultragenyx for research and development services performed. Costs incurred relating to the Collaboration Agreement consist of internal and external research and development costs, which primarily include salaries and benefits, lab supplies, preclinical research studies, clinical studies, consulting services, and commercial development. These costs are included in research and development expenses in the Company’s condensed consolidated statement of operations during the three and six months ended June 30, 2023 and three and six months ended June 30, 2022. Maugeri License Agreement On June 29, 2023 the Company entered into a license agreement (the “Agreement”) with ICS Maugeri S.p.A. SB ("Maugeri"), to focus on the development and commercialization of cardiac-related products by the Company based on Maugeri's inventions. Pursuant to the Agreement, Maugeri granted the Company an exclusive worldwide sublicensable license in certain Maugeri patent rights, including existing patent rights, and those in any improvements or know-how made in performance of the Agreement, and a non-exclusive worldwide sublicensable license in certain Maugeri know-how, including existing know-how, and on any improvement thereto, in each case, subject to certain conditions, that is necessary or reasonably useful to develop the licensed products under the terms of the Agreement. The Company will conduct certain activities agreed to by the parties with respect to the research and development of licensed products. A condition precedent to the effectiveness of the Agreement is regulatory review in Italy, which the Company anticipates will occur in the third quarter of 2023. The Company has agreed to pay to Maugeri an upfront license fee of € 1,500 which was recorded as research and development expense during the second quarter of 2023. Additionally, the Company agreed to cumulative developmental, regulatory, and commercial milestone payments of up to € 15,000 , cumulative sales milestone payments of up to € 15,000 , upon achievement of specified milestone events, and tiered royalties on worldwide net sales in the low-to-mid-single-digits. The Agreement continues until the latest expiry of (i) the last valid claim (as defined in the Agreement), (ii) regulatory exclusivity, and (iii) all payment obligations. Either party may terminate the agreement for the other party’s uncured material breach. The Company may also terminate the agreement in its sole discretion upon 60 days ’ prior written notice to Maugeri and payment of a fee. |
Acquisition
Acquisition | 6 Months Ended |
Jun. 30, 2023 | |
Business Combinations [Abstract] | |
Acquisition | 4. Acquisition On September 29, 2022 , the Company entered into an Agreement and Plan of Merger with AavantiBio. The Acquisition closed on December 2, 2022 and was announced on December 5, 2022. This acquisition allowed the Company to add to its pipeline of assets. The Company acquired AavantiBio for a total purchase price of $ 9,169 , including (i) $ 1 in cash and (ii) 1,354,258 shares of its common stock, par value $ 0.001 per share, with a fair value of $ 9,168 to AavantiBio equityholders. The price per share of the Company’s common stock used in the calculation of the purchase price is based on the closing price of Solid’s common stock on the Nasdaq Global Select Market on December 2, 2022, which was $ 6.77 . The Acquisition was accounted for as a business combination in which the Company, as the accounting acquirer, recorded the assets acquired and liabilities assumed from AavantiBio at their fair values as of the acquisition date. The Company recognized a gain on the purchase of AavantiBio of $ 18,236 as the net assets acquired of $ 27,405 were greater than the purchase price of $ 9,169 . Prior to recognizing the gain, the Company reassessed the measurement and recognition of identifiable assets acquired, and liabilities assumed and concluded that the valuation procedures and resulting measures were appropriate, in all material respects. The Company believes that its ability to negotiate a purchase price lower than the fair market value of the acquired net assets was due to a combination of factors, including the then prevailing market conditions and the uncertain future macroeconomic environment. The Company believes the seller, as a smaller, less well capitalized company, was motivated to complete the transaction under the terms described above as growing economic uncertainty and a rising interest rate environment negatively impacted their ability to raise additional capital. The Company incurred acquisition related costs of $ 0 for the three and six months ended June 30, 2023. The fair value was determined utilizing the fair value hierarchy as described in Note 2 and Note 5 to the Company's consolidated financial statements included in the Company's Annual Report on Form 10-K for the year ended December 31, 2022. The following table summarizes the fair values of the assets acquired and liabilities assumed from AavantiBio at the acquisition date. December 2, 2022 Assets Current assets: Cash and cash equivalents $ 31,524 Prepaid expenses and other current assets 403 Total current assets 31,927 Operating lease, right-of-use asset 1,027 Property and equipment 2,765 Other non-current assets 23 Total assets $ 35,742 Liabilities Current liabilities: Accounts payable $ 3,575 Accrued expenses 3,634 Operating lease liabilities 778 Total current liabilities 7,987 Operating lease liabilities, excluding current portion 350 Total liabilities 8,337 Net assets acquired 27,405 Total consideration paid 9,169 Gain on acquisition of business $ 18,236 For the period from December 3, 2022 to December 31, 2022, AavantiBio's revenue and net loss before taxes included within the consolidated statement of operations subsequent to the closing of the Acquisition was $ 0 and $ 6,041 , respectively. |
Fair Value of Financial Assets
Fair Value of Financial Assets and Liabilities | 6 Months Ended |
Jun. 30, 2023 | |
Fair Value Disclosures [Abstract] | |
Fair Value of Financial Assets and Liabilities | 5. Fair Value of Financial Assets and Liabilities The following tables present information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values: Fair Value Measurements as of June 30, 2023 Level 1 Level 2 Level 3 Total Assets: Cash equivalents $ — $ 65,134 $ — $ 65,134 Available-for-sale securities — 68,623 — 68,623 $ — $ 133,757 $ — $ 133,757 Fair Value Measurements as of December 31, 2022 Level 1 Level 2 Level 3 Total Assets: Cash equivalents $ — $ 69,374 $ — $ 69,374 Available-for-sale securities — 58,338 — 58,338 $ — $ 127,712 $ — $ 127,712 As of June 30, 2023 and December 31, 2022, the fair values of the Company’s cash equivalents and available-for-sale securities were determined using Level 2 inputs. During the six months ended June 30, 2023 and the year ended December 31, 2022, there were no transfers between Level 1, Level 2 and Level 3. The fair value of the Company’s cash, restricted cash, accounts payable, and accrued expenses and other current liabilities approximate their carrying value due to their short-term maturities. |
Available-for-Sale Securities
Available-for-Sale Securities | 6 Months Ended |
Jun. 30, 2023 | |
Investments, Debt and Equity Securities [Abstract] | |
Available-for-Sale Securities | 6. Available-for-Sale Securities As of June 30, 2023, the fair value of available-for-sale securities by type of security was as follows: June 30, 2023 Amortized Gross Gross Fair Investments: Treasury bills $ 68,609 $ 14 $ — $ 68,623 $ 68,609 $ 14 $ — $ 68,623 As of December 31, 2022, the fair value of available-for-sale securities by type of security was as follows: December 31, 2022 Amortized Gross Gross Fair Investments: Treasury bill $ 34,780 $ — $ ( 30 ) $ 34,750 Corporate bond securities 23,626 — ( 38 ) 23,588 $ 58,406 $ — $ ( 68 ) $ 58,338 The estimated fair value and amortized cost of the Company’s available-for-sale securities as of June 30, 2023 by contractual maturity are summarized as follows: June 30, 2023 Amortized Fair Due in one year or less $ 68,609 $ 68,623 Total available-for-sale securities $ 68,609 $ 68,623 The weighted average maturity of the Company’s available-for-sale securities as of June 30, 2023 was approximately 0.4 years. The estimated fair value and amortized cost of the Company’s available-for-sale securities as of December 31, 2022 by contractual maturity are summarized as follows: December 31, 2022 Amortized Fair Due in one year or less $ 58,406 $ 58,338 Total available-for-sale securities $ 58,406 $ 58,338 The weighted average maturity of the Company’s available-for-sale securities as of December 31, 2022 was approximately 0.5 years. |
Property and Equipment
Property and Equipment | 6 Months Ended |
Jun. 30, 2023 | |
Property, Plant and Equipment [Abstract] | |
Property and Equipment | 7. Property and Equipment Property and equipment consists of the following: June 30, December 31, Furniture and fixtures $ 936 $ 868 Laboratory equipment 15,853 16,416 Leasehold improvements 481 384 Computer equipment 677 677 Computer software 553 553 Construction in process 451 1,715 18,951 20,613 Less accumulated depreciation 11,560 10,956 $ 7,391 $ 9,657 Depreciation expense was $ 703 and $ 1,406 for the three and six months ended June 30, 2023 , respectively. Depreciation expense was $ 722 and $ 1,431 for the three and six months ended June 30, 2022, respectively. During three and six months ended June 30, 2023, the Company recognized an impairment loss of $ 0 and $ 374 , respectively. During each of the three and six months ended June 30, 2022 , the Company recognized an impairment loss of $ 0 . |
Prepaid Expenses and Other Curr
Prepaid Expenses and Other Current Assets | 6 Months Ended |
Jun. 30, 2023 | |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | |
Prepaid Expenses and Other Current Assets | 8. Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consist of the following: June 30, December 31, Prepaid research and development expenses $ 4,385 $ 2,913 Prepaid expenses and other assets 2,898 3,003 $ 7,283 $ 5,916 |
Accrued Expenses and Other Curr
Accrued Expenses and Other Current Liabilities | 6 Months Ended |
Jun. 30, 2023 | |
Payables and Accruals [Abstract] | |
Accrued Expenses and Other Current Liabilities | 9. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consist of the following: June 30, December 31, Accrued research and development $ 4,991 $ 3,033 Accrued compensation 3,920 8,370 Accrued other 1,598 5,288 $ 10,509 $ 16,691 |
Stockholders' Equity
Stockholders' Equity | 6 Months Ended |
Jun. 30, 2023 | |
Equity [Abstract] | |
Stockholders' Equity | 10. Stockholders’ Equity In July 2019, the Company issued and sold in a private placement (i) 707,168 shares of its common stock at a price per share of $ 69.75 and (ii) 153,046 pre-funded warrants to purchase shares of its common stock at a price per warrant of $ 69.60 . Each pre-funded warrant was exercisable for one share of common stock at an exercise price of $ 0.15 and the pre-funded warrants had no expiration date. In October 2020, 9,158 of these pre-funded warrants were exercised. As of December 31, 2022, there were no pre-funded warrants outstanding. In March 2021, the Company issued and sold in a public offering 1,666,666 shares of its common stock at a price to the public of $ 83.63 per share. The Company received net proceeds of $ 134,878 after deducting underwriting discounts and commissions and offering expenses. On December 2, 2022, the Company issued and sold 10,638,290 shares of its common stock at a price per share of $ 7.05 in a private placement, which closed immediately following the Acquisition. The Company received net proceeds of $ 72,551 after deducting offering costs. During the three months ended June 30, 2023, the Company issued and sold 420,000 shares of its common stock pursuant to the Company's "at-the-market offering" sales agreement, between the Company and Jefferies LLC. The Company received net proceeds of $ 2,539 . |
Equity-Based Compensation
Equity-Based Compensation | 6 Months Ended |
Jun. 30, 2023 | |
Share-Based Payment Arrangement [Abstract] | |
Equity-Based Compensation | 11. Equity-Based Compensation In connection with the closing of the Company’s initial public offering, the Board of Directors and stockholders approved the 2018 Omnibus Incentive Plan (the “2018 Plan”), which provides for the reservation of 333,400 shares of common stock for equity awards. On June 16, 2020, the Company’s stockholders approved the 2020 Equity Incentive Plan (as amended or restated, the “2020 Plan”) which consisted of, at the time of approval (i) 200,000 shares of common stock and (ii) additional shares of common stock (up to 325,268 ) as is equal to (i) the number of shares reserved under the 2018 Plan that remain available for grant under the 2018 Plan as of immediately prior to the date the 2020 Plan was approved by the Company’s stockholders and (ii) the number of shares subject to awards granted under the 2018 Plan which awards expire, terminate or are otherwise surrendered, cancelled, forfeited or repurchased by the Company at their original issuance price pursuant to a contractual repurchase right. As of the effective date of the 2020 Plan, no further awards will be made under the 2018 Plan. Any options or awards outstanding under the 2018 Plan remain outstanding and effective and are governed by their existing terms. In June 2021, the Company’s stockholders approved an amendment to the 2020 Plan to reserve an additional 466,666 shares of common stock for issuance under the plan. On December 1, 2022, the Company's stockholders approved an amendment and restatement of the 2020 Plan to (i) increase the number of shares of common stock reserved for issuance under the plan by 866,666 shares to 1,533,333 shares, subject to adjustment in the event of stock splits and other similar events, (ii) provide for an annual increase, to be added on the first day of each fiscal year during the term of the plan, beginning with the fiscal year ending December 31, 2023, of 5 % of the number of shares of common stock outstanding on the first day of such fiscal year or a lesser number of shares determined by the Board of Directors, (iii) provide that up to 1,858,601 shares of common stock may be granted as “incentive stock options” under the 2020 Plan, (iv) extend the term of the plan to December 1, 2032 and (v) revise certain provisions of the plan relating to the Board of Director’s ability to delegate authority to make awards under the plan. Under the 2020 Plan, stock options may not be granted at less than fair value on the date of grant. As of June 30, 2023 , 838,659 shares remained available for future issuance under the 2020 Plan. In June 2021, the Company's stockholders also approved the 2021 Employee Stock Purchase Plan (“ESPP”), which provides for 73,525 shares to be available for purchase by eligible employees according to its terms. The first offering period under the ESPP commenced on September 1, 2021. On June 6, 2023, the Company's stockholders approved an amendment and restatement of the ESPP to (i) increase the number of shares of common stock reserved for issuance under the ESPP from 73,525 to 473,525 and (ii) provide for an annual increase to be added on the first day of each fiscal year, beginning with the fiscal year ending December 31, 2024 and ending with the fiscal year ending December 31, 2033, equal to the least of (a) 293,597 shares of common stock, (b) one percent ( 1 %) of the outstanding shares of common stock on such date and (c) the number of shares of common stock determined by the Board of Directors. As of June 30, 2023 , 426,503 shares remained available for future issuance under the ESPP. During the three and six months ended June 30, 2023 , the Company granted options to purchase 226,500 and 922,096 shares of common stock under the 2020 Plan and options to purchase 0 and 90,000 shares of common stock as an inducement award in accordance with Nasdaq Listing Rule 5635(c)(4), respectively. During the three and six months ended June 30, 2022 , the Company granted options to purchase 127,167 and 301,905 shares of common stock, respectively. During the three and six months ended June 30, 2023 , the Company granted 181,945 and 556,822 restricted stock units under the 2020 Plan and 0 and 45,000 restricted stock units as an inducement award in accordance with Nasdaq Listing Rule 5635(c)(4), respectively. During the three and six months ended June 30, 2022 , the Company granted 65,283 and 162,050 restricted stock units, respectively. The Company recorded equity-based compensation expense related to all of its share-based awards to employees and non-employees in the following captions within its condensed consolidated statements of operations: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Research and development $ 710 $ 394 $ 1,608 $ 1,574 General and administrative 1,234 1,420 2,454 2,852 Total $ 1,944 $ 1,814 $ 4,062 $ 4,426 |
Income Taxes
Income Taxes | 6 Months Ended |
Jun. 30, 2023 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | 12. Income Taxes During the three and six months ended June 30, 2023 and 2022, the Company recorded no income tax benefits for the net operating losses incurred or for the research and development tax credits and orphan drug credits generated in each year due to its uncertainty of realizing a benefit from those items. The Company has provided a valuation allowance for the full amount of its net deferred tax assets because, at June 30, 2023 and December 31, 2022, it was more likely than not that any future benefit from deductible temporary differences and net operating loss and tax credit carryforwards would not be realized. As of June 30, 2023 and December 31, 2022, the Company had no t recorded any amounts for unrecognized tax benefits. The Company files income tax returns as prescribed by the tax laws of the jurisdictions in which it operates. In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending income tax examinations. The Company’s C-Corporation tax years beginning with the year ended December 31, 2019 are open under statute. Any tax credit or net operating loss carryforward can be adjusted in future periods after the respective year of generation’s statute of limitation has closed. |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2023 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 13. Commitments and Contingencies Letter of Credit The Company had an outstanding letter of credit in the amount of $ 1,833 at June 30, 2023 and December 31, 2022, which was required as a condition of the Company’s office and laboratory lease. Indemnification Agreements In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters, including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with its executive officers and members of its Board of Directors that require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as executive officers or directors. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnification arrangements. The Company does not believe that the outcome of any claims under indemnification arrangements will have a material effect on its financial position, results of operations or cash flows, and it has not accrued any liabilities related to such obligations in its consolidated financial statements as of June 30, 2023 and December 31, 2022. Legal Proceedings The Company may periodically become subject to legal proceedings and claims arising in connection with ongoing business activities, including claims or disputes related to patents that have been issued or that are pending in the field of research on which the Company is focused. The Company is not aware of any material legal proceedings or claims as of June 30, 2023 . |
Net Loss per Share
Net Loss per Share | 6 Months Ended |
Jun. 30, 2023 | |
Earnings Per Share [Abstract] | |
Net Loss per Share | 14. Net Loss per Share Basic and diluted net loss per share attributable to common stockholders were calculated as follows: The numerator for basic and diluted net loss per share attributable to common stockholders is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Net loss attributable to common stockholders $ ( 24,629 ) $ ( 25,092 ) $ ( 54,699 ) $ ( 50,420 ) The denominator is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Weighted average shares of common stock outstanding, 19,663,672 7,523,964 19,618,517 7,515,673 Net loss per share attributable to common stockholders, basic and diluted is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Net loss per share attributable to common stockholders $ ( 1.25 ) $ ( 3.33 ) $ ( 2.79 ) $ ( 6.71 ) The following potential common stock equivalents, presented based on amounts outstanding at each period end, were excluded from the calculation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect for the three and six months ended June 30, 2023: 2023 2022 Options to purchase shares of common stock 2,229,684 1,433,968 Unvested restricted stock units 963,724 512,557 3,193,408 1,946,525 |
Restructuring
Restructuring | 6 Months Ended |
Jun. 30, 2023 | |
Restructuring and Related Activities [Abstract] | |
Restructuring | 15. Restructuring April 2022 Plan In April 2022, the Company implemented changes to its corporate strategy to prioritize the advancement of its then-key programs, SGT-001 and SGT-003. In connection with the changes to corporate operations, the Company reduced headcount by approximately 35 percent. During the year ended December 31, 2022, the Company recorded and paid aggregate restructuring charges of $ 1,520 related to severance and other employee related costs in connection with the changes to its corporate strategy. The Company does not expect to incur any additional significant costs associated with this restructuring. November 2022 Plan In November 2022, the Company’s Board of Directors approved a plan to reduce the Company’s workforce by approximately 18 percent. These reductions were completed by December 5, 2022. This plan was designed to streamline the Company’s operating structure following the Acquisition. The Company recorded a restructuring charge in the fourth quarter of 2022 of $ 5,658 related to the reduction in force, consisting of severance and other employee termination benefits. The Company paid $ 2,903 of this amount during the six months ended June 30, 2023 and $ 1,737 during the year ended December 31, 2022. The Company expects that approximately the remaining $ 1,018 will be paid by the first quarter of 2024. One-Time Employee April 2022 November 2022 Accrued restructuring charges as of December 31, 2021 $ — $ — Accrual recorded as a result of restructuring charges 1,520 5,658 Amounts paid during the period ( 1,520 ) ( 1,737 ) Accrued restructuring charges as of December 31, 2022 $ — $ 3,921 Accrual recorded as a result of restructuring charges — — Amounts paid during the period — ( 2,903 ) Accrued restructuring charges as of June 30, 2023 $ — $ 1,018 |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2023 | |
Accounting Policies [Abstract] | |
Use of Estimates | Use of Estimates The preparation of the Company’s condensed consolidated financial statements in conformity with GAAP requires management to make estimates, judgments and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, estimates related to revenue recognition, the recognition of research and development expenses and equity-based compensation. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from the Company’s estimates. The Company has made estimates of the impact of the recent COVID-19 pandemic within its financial statements and there may be changes to those estimates in future periods. Actual results could differ from the Company’s estimates. |
Cash Equivalents | Cash Equivalents The Company considers all short-term, highly liquid investments with original maturities of 90 days or less at acquisition date to be cash equivalents. |
Restricted Cash | Restricted Cash The Company held restricted cash of $ 1,833 in a restricted bank account as a security deposit for a lease of the Company’s facilities as of June 30, 2023 and December 31, 2022. The Company has included restricted cash of $ 1,833 classified as non-current assets as of June 30, 2023 and December 31, 2022. A reconciliation of the amounts of cash and cash equivalents and restricted cash from the cash flow statement to the balance sheet is as follows: June 30, December 31, June 30, December 31, Cash and cash equivalents as presented on balance sheet $ 91,569 $ 155,384 $ 54,311 $ 119,136 Restricted cash, current, as presented on balance sheet — — 237 — Restricted cash, non-current, as presented on balance sheet 1,833 1,833 1,833 2,070 Cash and cash equivalents and restricted cash as presented on $ 93,402 $ 157,217 $ 56,381 $ 121,206 |
Leases | Leases The Company has operating leases for laboratory and office space in Massachusetts, North Carolina and Florida. In June 2021, the Company entered into a lease with Hood Park LLC (“Landlord”), pursuant to which the Company leases approximately 49,869 square feet of office, laboratory, research and development and manufacturing space located in Charlestown, Massachusetts (“Premises”). The Company relocated its corporate headquarters to the Premises in June 2022. The initial term of the lease commenced in June 2022 when the construction of the lessor assets was substantially completed and continues for a ten-year period, unless earlier terminated. The lease provides the Company with an option to extend the lease for an additional five-year term. The Company and the Landlord were each obligated to undertake certain improvements prior to the commencement of the lease, and significant improvements were completed as of June 2022. The monthly lease payment is approximately $ 305 with annual escalation of approximately 3 %. The lease includes a $ 10,223 construction allowance. The Company was required to post a customary letter of credit in the amount of $ 1,833 , subject to decrease on a set schedule, as a security deposit pursuant to the lease. During the year ended December 31, 2022, the Company recorded a failed sales-leaseback transaction related to certain lab equipment. The related financing liabilities are recorded on the Company's consolidated balance sheets within financing labilities. In connection with this transaction, the Company also recorded a cash inflow within financing activities under proceeds from financing liabilities of $ 2,143 . |
Segment Data | Segment Data The Company manages its operations as a single segment for the purposes of assessing performance and making operating decisions. The Company’s singular focus is on developing treatments through gene therapy and other means for patients with neuromuscular and cardiac diseases. All of the Company’s tangible assets are held in the United States. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Accounting Policies [Abstract] | |
Reconciliation of Amounts From Cash Flow Statement to Balance Sheet | A reconciliation of the amounts of cash and cash equivalents and restricted cash from the cash flow statement to the balance sheet is as follows: June 30, December 31, June 30, December 31, Cash and cash equivalents as presented on balance sheet $ 91,569 $ 155,384 $ 54,311 $ 119,136 Restricted cash, current, as presented on balance sheet — — 237 — Restricted cash, non-current, as presented on balance sheet 1,833 1,833 1,833 2,070 Cash and cash equivalents and restricted cash as presented on $ 93,402 $ 157,217 $ 56,381 $ 121,206 |
Acquisition (Tables)
Acquisition (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Business Combinations [Abstract] | |
Summary of Fair Values of Assets Acquired and Liabilities Assumed | The following table summarizes the fair values of the assets acquired and liabilities assumed from AavantiBio at the acquisition date. December 2, 2022 Assets Current assets: Cash and cash equivalents $ 31,524 Prepaid expenses and other current assets 403 Total current assets 31,927 Operating lease, right-of-use asset 1,027 Property and equipment 2,765 Other non-current assets 23 Total assets $ 35,742 Liabilities Current liabilities: Accounts payable $ 3,575 Accrued expenses 3,634 Operating lease liabilities 778 Total current liabilities 7,987 Operating lease liabilities, excluding current portion 350 Total liabilities 8,337 Net assets acquired 27,405 Total consideration paid 9,169 Gain on acquisition of business $ 18,236 |
Fair Value of Financial Asset_2
Fair Value of Financial Assets and Liabilities (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Fair Value Disclosures [Abstract] | |
Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis and Indicate Level of Fair Value Hierarchy Utilized | The following tables present information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values: Fair Value Measurements as of June 30, 2023 Level 1 Level 2 Level 3 Total Assets: Cash equivalents $ — $ 65,134 $ — $ 65,134 Available-for-sale securities — 68,623 — 68,623 $ — $ 133,757 $ — $ 133,757 Fair Value Measurements as of December 31, 2022 Level 1 Level 2 Level 3 Total Assets: Cash equivalents $ — $ 69,374 $ — $ 69,374 Available-for-sale securities — 58,338 — 58,338 $ — $ 127,712 $ — $ 127,712 |
Available-for-Sale Securities (
Available-for-Sale Securities (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Investments, Debt and Equity Securities [Abstract] | |
Schedule of Fair Value of Available-for-Sale Securities by Type of Security | As of June 30, 2023, the fair value of available-for-sale securities by type of security was as follows: June 30, 2023 Amortized Gross Gross Fair Investments: Treasury bills $ 68,609 $ 14 $ — $ 68,623 $ 68,609 $ 14 $ — $ 68,623 As of December 31, 2022, the fair value of available-for-sale securities by type of security was as follows: December 31, 2022 Amortized Gross Gross Fair Investments: Treasury bill $ 34,780 $ — $ ( 30 ) $ 34,750 Corporate bond securities 23,626 — ( 38 ) 23,588 $ 58,406 $ — $ ( 68 ) $ 58,338 |
Summary Estimated Fair Value and Amortized Cost of Available-for-Sale Securities by Contractual Maturity | The estimated fair value and amortized cost of the Company’s available-for-sale securities as of June 30, 2023 by contractual maturity are summarized as follows: June 30, 2023 Amortized Fair Due in one year or less $ 68,609 $ 68,623 Total available-for-sale securities $ 68,609 $ 68,623 The estimated fair value and amortized cost of the Company’s available-for-sale securities as of December 31, 2022 by contractual maturity are summarized as follows: December 31, 2022 Amortized Fair Due in one year or less $ 58,406 $ 58,338 Total available-for-sale securities $ 58,406 $ 58,338 |
Property and Equipment (Tables)
Property and Equipment (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Property, Plant and Equipment [Abstract] | |
Summary of Property and Equipment | Property and equipment consists of the following: June 30, December 31, Furniture and fixtures $ 936 $ 868 Laboratory equipment 15,853 16,416 Leasehold improvements 481 384 Computer equipment 677 677 Computer software 553 553 Construction in process 451 1,715 18,951 20,613 Less accumulated depreciation 11,560 10,956 $ 7,391 $ 9,657 |
Prepaid Expenses and Other Cu_2
Prepaid Expenses and Other Current Assets (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | |
Schedule of Prepaid Expenses and Other Current Assets | Prepaid expenses and other current assets consist of the following: June 30, December 31, Prepaid research and development expenses $ 4,385 $ 2,913 Prepaid expenses and other assets 2,898 3,003 $ 7,283 $ 5,916 |
Accrued Expenses and Other Cu_2
Accrued Expenses and Other Current Liabilities (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Payables and Accruals [Abstract] | |
Summary of Accrued Expenses and Other Current Liabilities | Accrued expenses and other current liabilities consist of the following: June 30, December 31, Accrued research and development $ 4,991 $ 3,033 Accrued compensation 3,920 8,370 Accrued other 1,598 5,288 $ 10,509 $ 16,691 |
Equity-Based Compensation (Tabl
Equity-Based Compensation (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Share-Based Payment Arrangement [Abstract] | |
Schedule of Equity-based Compensation Expense | The Company recorded equity-based compensation expense related to all of its share-based awards to employees and non-employees in the following captions within its condensed consolidated statements of operations: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Research and development $ 710 $ 394 $ 1,608 $ 1,574 General and administrative 1,234 1,420 2,454 2,852 Total $ 1,944 $ 1,814 $ 4,062 $ 4,426 |
Net Loss per Share (Tables)
Net Loss per Share (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Earnings Per Share [Abstract] | |
Schedule of Basic and Diluted Net Loss per Share Attributable to Common Stockholders | The numerator for basic and diluted net loss per share attributable to common stockholders is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Net loss attributable to common stockholders $ ( 24,629 ) $ ( 25,092 ) $ ( 54,699 ) $ ( 50,420 ) The denominator is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Weighted average shares of common stock outstanding, 19,663,672 7,523,964 19,618,517 7,515,673 Net loss per share attributable to common stockholders, basic and diluted is as follows: Three Months Ended June 30, Six Months Ended June 30, 2023 2022 2023 2022 Net loss per share attributable to common stockholders $ ( 1.25 ) $ ( 3.33 ) $ ( 2.79 ) $ ( 6.71 ) |
Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share Attributable to Common Stockholders | The following potential common stock equivalents, presented based on amounts outstanding at each period end, were excluded from the calculation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect for the three and six months ended June 30, 2023: 2023 2022 Options to purchase shares of common stock 2,229,684 1,433,968 Unvested restricted stock units 963,724 512,557 3,193,408 1,946,525 |
Restructuring (Tables)
Restructuring (Tables) | 6 Months Ended |
Jun. 30, 2023 | |
Restructuring and Related Activities [Abstract] | |
Schedule of Accrued Restructuring Charges | One-Time Employee April 2022 November 2022 Accrued restructuring charges as of December 31, 2021 $ — $ — Accrual recorded as a result of restructuring charges 1,520 5,658 Amounts paid during the period ( 1,520 ) ( 1,737 ) Accrued restructuring charges as of December 31, 2022 $ — $ 3,921 Accrual recorded as a result of restructuring charges — — Amounts paid during the period — ( 2,903 ) Accrued restructuring charges as of June 30, 2023 $ — $ 1,018 |
Nature of the Business and Ba_2
Nature of the Business and Basis of Presentation - Additional Information (Detail) $ in Thousands | 3 Months Ended | 6 Months Ended | ||||||
Dec. 02, 2022 USD ($) shares | Oct. 27, 2022 shares | Jun. 30, 2023 USD ($) shares | Jun. 30, 2022 USD ($) shares | Jun. 30, 2023 USD ($) shares | Jun. 30, 2022 USD ($) shares | Dec. 31, 2022 USD ($) shares | Oct. 28, 2022 shares | |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] | ||||||||
Net loss | $ 24,629 | $ 25,092 | $ 54,699 | $ 50,420 | ||||
Accumulated deficit | 617,437 | 617,437 | $ 562,738 | |||||
Net cash used in operating activities | 55,460 | $ 43,068 | ||||||
Cash, cash equivalents and available-for-sale securities | $ 160,192 | $ 160,192 | ||||||
Reverse stock split of outstanding shares of common stock | one-for-15 | |||||||
Stockholders' equity note, stock split, conversion ratio | 0.015 | |||||||
Common stock, shares authorized | shares | 20,000,000 | 60,000,000 | 300,000,000 | 60,000,000 | 300,000,000 | 60,000,000 | 60,000,000 | |
Proceeds from issuance of common stock | $ 2,539 | |||||||
Restricted cash | $ 1,833 | $ 1,833 | ||||||
At-the-Market Offering Sales Agreement [Member] | ||||||||
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] | ||||||||
Common stock shares issued | shares | 420,000 | |||||||
Proceeds from issuance of common stock | $ 2,539 | |||||||
Securities Purchase Agreement [Member] | ||||||||
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] | ||||||||
Net proceeds from private placement | $ 72,551 | |||||||
Common Stock [Member] | ||||||||
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] | ||||||||
Common stock shares issued | shares | 420,000 | 420,000 | ||||||
Common Stock [Member] | Securities Purchase Agreement [Member] | ||||||||
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] | ||||||||
Common stock shares issued | shares | 10,638,290 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands | 1 Months Ended | 6 Months Ended | |||
Jun. 30, 2021 USD ($) ft² | Jun. 30, 2023 USD ($) shares | Dec. 31, 2022 USD ($) shares | Jun. 30, 2022 USD ($) | Dec. 31, 2021 USD ($) | |
Significant Accounting Policies [Line Items] | |||||
Restricted cash deposit | $ 1,833 | $ 1,833 | |||
Restricted cash noncurrent | 1,833 | $ 1,833 | $ 1,833 | $ 2,070 | |
Proceeds from financing liabilities | $ 2,143 | ||||
Common stock, shares issued | shares | 20,044,389 | 19,556,732 | |||
Office laboratory [Member] | Hood Park LLC [Member] | |||||
Significant Accounting Policies [Line Items] | |||||
Area of lease agreement | ft² | 49,869 | ||||
Lease description | The Company relocated its corporate headquarters to the Premises in June 2022. The initial term of the lease commenced in June 2022 when the construction of the lessor assets was substantially completed and continues for a ten-year period, unless earlier terminated. The lease provides the Company with an option to extend the lease for an additional five-year term. The Company and the Landlord were each obligated to undertake certain improvements prior to the commencement of the lease, and significant improvements were completed as of June 2022. | ||||
Operating lease, monthly payments | $ 305 | ||||
Operating lease payments annual escalation percentage | 3% | ||||
Construction allowance | $ 10,223 | ||||
Letter of credit amount | $ 1,833 |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Reconciliation of Amounts From Cash Flow Statement to Balance Sheet (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 | Jun. 30, 2022 | Dec. 31, 2021 |
Reconciliation Of Beginning And End Of Period Amounts From Cash Flow Statement To Balance Sheet [Abstract] | ||||
Cash and cash equivalents as presented on balance sheet | $ 91,569 | $ 155,384 | $ 54,311 | $ 119,136 |
Restricted cash, current, as presented on balance sheet | 237 | |||
Restricted cash, non-current, as presented on balance sheet | 1,833 | 1,833 | 1,833 | 2,070 |
Cash and cash equivalents and restricted cash as presented on cash flow statement | $ 93,402 | $ 157,217 | $ 56,381 | $ 121,206 |
License and Research Agreemen_2
License and Research Agreements - Additional Information (Detail) | 3 Months Ended | 6 Months Ended | 9 Months Ended | |||||
Jun. 29, 2023 EUR (€) | Oct. 22, 2020 USD ($) $ / shares shares | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Sep. 30, 2022 | Dec. 31, 2022 USD ($) | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Proceeds from issuance of common stock, net of issuance costs | $ 2,539,000 | |||||||
Maugeri License Agreement [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Agreement termination notice period | 60 days | |||||||
Upfront license fee | € | € 1,500,000 | |||||||
Maugeri License Agreement [Member] | Maximum [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Cumulative developmental, regulatory, and commercial milestone payments | € | 15,000,000 | |||||||
Cumulative sales milestone payments | € | € 15,000,000 | |||||||
Related Party [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Collaboration revenue - related party | $ 6,169,000 | $ 8,094,000 | ||||||
Ultragenyx [Member] | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Agreement termination notice period | 90 days | |||||||
Issued and sold shares of common stock | shares | 521,719 | |||||||
Common stock issued price per share | $ / shares | $ 76.6695 | |||||||
Proceeds from issuance of common stock, net of issuance costs | $ 40,000,000 | |||||||
Percentage of outstanding common stock | 14.45% | 2.60% | ||||||
Transaction price determined under ASC 606 | $ 22,513,000 | |||||||
Transaction price | 0 | |||||||
Deferred revenue - related party | $ 0 | 0 | $ 0 | |||||
Ultragenyx [Member] | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member] | Minimum [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Percentage of outstanding common stock | 10% | |||||||
Ultragenyx [Member] | Related Party [Member] | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member] | ||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||
Collaboration revenue - related party | 0 | $ 6,169,000 | 0 | $ 8,094,000 | ||||
Related party collaboration receivables | $ 0 | $ 0 | $ 0 |
Acquisition - Additional Inform
Acquisition - Additional Information (Detail) - AavantiBio, Inc [Member] - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | |
Dec. 02, 2022 | Dec. 31, 2022 | Jun. 30, 2023 | Jun. 30, 2023 | |
Business Acquisition [Line Items] | ||||
Business acquisition, effective date of acquisition | Sep. 29, 2022 | |||
Business acquisition, Acquisition completion date | Dec. 02, 2022 | |||
Total purchase price | $ 9,169 | |||
Cash payment | $ 1 | |||
Number of shares of common stock | 1,354,258 | |||
Business acquisition, share price | $ 0.001 | |||
Business Acquisition, fair value | $ 9,168 | |||
Gain on acquisition | 18,236 | |||
Acquisition related costs | $ 0 | $ 0 | ||
Net assets acquired | $ 27,405 | |||
Revenues | $ 0 | |||
Net loss before taxes | $ 6,041 | |||
Common Stock [Member] | ||||
Business Acquisition [Line Items] | ||||
Business acquisition, share price | $ 6.77 | |||
Minimum [Member] | ||||
Business Acquisition [Line Items] | ||||
Total purchase price | $ 9,169 |
Acquisition - Summary of Fair V
Acquisition - Summary of Fair Values of Assets Acquired and Liabilities Assumed (Detail) - AavantiBio, Inc [Member] $ in Thousands | Dec. 02, 2022 USD ($) |
Current assets: | |
Cash and cash equivalents | $ 31,524 |
Prepaid expenses and other current assets | 403 |
Total current assets | 31,927 |
Operating lease, right-of-use asset | 1,027 |
Property and equipment | 2,765 |
Other non-current assets | 23 |
Total assets | 35,742 |
Current liabilities: | |
Accounts payable | 3,575 |
Accrued expenses | 3,634 |
Operating lease liabilities | 778 |
Total current liabilities | 7,987 |
Operating lease liabilities, excluding current portion | 350 |
Total liabilities | 8,337 |
Net assets acquired | 27,405 |
Total consideration paid | 9,169 |
Gain on acquisition of business | $ 18,236 |
Fair Value of Financial Asset_3
Fair Value of Financial Assets and Liabilities - Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis and Indicate Level of Fair Value Hierarchy Utilized (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Assets: | ||
Cash equivalents | $ 65,134 | $ 69,374 |
Available-for-sale securities | 68,623 | 58,338 |
Assets Fair Value Disclosure | 133,757 | 127,712 |
Level 2 [Member] | ||
Assets: | ||
Cash equivalents | 65,134 | 69,374 |
Available-for-sale securities | 68,623 | 58,338 |
Assets Fair Value Disclosure | $ 133,757 | $ 127,712 |
Fair Value of Financial Asset_4
Fair Value of Financial Assets and Liabilities - Additional Information (Detail) - USD ($) | 6 Months Ended | 12 Months Ended |
Jun. 30, 2023 | Dec. 31, 2022 | |
Fair Value Disclosures [Abstract] | ||
Fair value, assets, transfers into level 3, amount | $ 0 | $ 0 |
Fair value, assets, transfers out of level 3, amount | 0 | 0 |
Fair value, assets, transfers into level 2, amount | 0 | 0 |
Fair value, assets, transfers out of level 2, amount | 0 | 0 |
Fair value, assets, transfers into level 1, amount | 0 | 0 |
Fair value, assets, transfers out of level 1, amount | $ 0 | $ 0 |
Available-for-Sale Securities -
Available-for-Sale Securities - Schedule of Fair Value of Available-for-Sale Securities by Type of Security (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost | $ 68,609 | $ 58,406 |
Gross Unrealized Gain | 14 | |
Gross Unrealized Loss | (68) | |
Fair Value | 68,623 | 58,338 |
Treasury Bills [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost | 68,609 | 34,780 |
Gross Unrealized Gain | 14 | |
Gross Unrealized Loss | (30) | |
Fair Value | $ 68,623 | 34,750 |
Corporate Bond Securities [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost | 23,626 | |
Gross Unrealized Loss | (38) | |
Fair Value | $ 23,588 |
Available-for-Sale Securities_2
Available-for-Sale Securities - Summary Estimated Fair Value and Amortized Cost of Available-for-Sale Securities by Contractual Maturity (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Investments, Debt and Equity Securities [Abstract] | ||
Due in one year or less, amortized cost | $ 68,609 | $ 58,406 |
Amortized Cost | 68,609 | 58,406 |
Due in one year or less, fair value | 68,623 | 58,338 |
Total available-for-sale securities, fair value | $ 68,623 | $ 58,338 |
Available-for-Sale Securities_3
Available-for-Sale Securities - Additional Information (Detail) | 6 Months Ended | 12 Months Ended |
Jun. 30, 2023 | Dec. 31, 2022 | |
Investments, Debt and Equity Securities [Abstract] | ||
Available-for-sale securities average maturity period | 4 months 24 days | 6 months |
Property and Equipment - Summar
Property and Equipment - Summary of Property and Equipment (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | $ 18,951 | $ 20,613 |
Less accumulated depreciation | 11,560 | 10,956 |
Property and equipment, net | 7,391 | 9,657 |
Furniture and Fixtures [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 936 | 868 |
Laboratory Equipment [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 15,853 | 16,416 |
Leasehold Improvements [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 481 | 384 |
Computer Equipment [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 677 | 677 |
Computer Software [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 553 | 553 |
Construction in Progress [Member] | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | $ 451 | $ 1,715 |
Property and Equipment - Additi
Property and Equipment - Additional Information (Detail) - USD ($) | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | |
Property, Plant and Equipment [Abstract] | ||||
Depreciation expense | $ 703,000 | $ 722,000 | $ 1,406,000 | $ 1,431,000 |
Impairment loss | $ 0 | $ 0 | $ 374,000 | $ 0 |
Prepaid Expenses and Other Cu_3
Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | ||
Prepaid research and development expenses | $ 4,385 | $ 2,913 |
Prepaid expenses and other assets | 2,898 | 3,003 |
Prepaid expenses and other current assets | $ 7,283 | $ 5,916 |
Accrued Expenses and Other Cu_3
Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Accrued Expenses And Other Current Liabilities [Line Items] | ||
Accrued expenses and other current liabilities | $ 10,509 | $ 16,691 |
Accrued Research and Development [Member] | ||
Accrued Expenses And Other Current Liabilities [Line Items] | ||
Accrued expenses and other current liabilities | 4,991 | 3,033 |
Accrued Compensation [Member] | ||
Accrued Expenses And Other Current Liabilities [Line Items] | ||
Accrued expenses and other current liabilities | 3,920 | 8,370 |
Accrued Other [Member] | ||
Accrued Expenses And Other Current Liabilities [Line Items] | ||
Accrued expenses and other current liabilities | $ 1,598 | $ 5,288 |
Stockholders' Equity - Addition
Stockholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||||
Dec. 02, 2022 | Mar. 31, 2021 | Oct. 31, 2020 | Jul. 31, 2019 | Jun. 30, 2023 | Jun. 30, 2023 | Dec. 31, 2022 | |
Class Of Stock [Line Items] | |||||||
Proceeds from issuance of common stock, net of issuance costs | $ 2,539 | ||||||
Public Offering [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Stock issued and sold | 1,666,666 | ||||||
Common stock issued price per share | $ 83.63 | ||||||
Proceeds from issuance of common stock, net of issuance costs | $ 134,878 | ||||||
At-the-Market Offering Sales Agreement [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Stock issued and sold | 420,000 | ||||||
Proceeds from issuance of common stock, net of issuance costs | $ 2,539 | ||||||
Common Stock [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Stock issued and sold | 420,000 | 420,000 | |||||
Common Stock [Member] | Private Placement [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Stock issued and sold | 10,638,290 | 707,168 | |||||
Common stock issued price per share | $ 7.05 | $ 69.75 | |||||
Company received net proceeds | $ 72,551 | ||||||
Pre-Funded Warrants [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Warrants exercised | 9,158 | ||||||
Warrants outstanding | 0 | ||||||
Pre-Funded Warrants [Member] | Private Placement [Member] | |||||||
Class Of Stock [Line Items] | |||||||
Warrants to purchase common stock | 153,046 | ||||||
Warrants price per share | $ 69.6 | ||||||
Warrants exercisable for common stock | 1 | ||||||
Common stock warrants exercise price per share | $ 0.15 |
Equity-Based Compensation - Add
Equity-Based Compensation - Additional Information (Detail) - shares | 1 Months Ended | 3 Months Ended | 6 Months Ended | |||||
Jun. 16, 2020 | Jun. 30, 2021 | Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Jun. 06, 2023 | Dec. 01, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Common stock purchased | 127,167 | 301,905 | ||||||
Restricted Stock Units [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Restricted stock units granted | 65,283 | 162,050 | ||||||
Inducement Award [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Common stock purchased | 0 | 90,000 | ||||||
Restricted stock units granted | 0 | 45,000 | ||||||
Incentive Stock Options [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of shares available for future issuance | 1,858,601 | |||||||
2018 Omnibus Incentive Plan [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of shares authorized for common stock for equity awards | 333,400 | 333,400 | ||||||
2020 Equity Incentive Plan [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of shares authorized for common stock for equity awards | 200,000 | |||||||
Number of additional shares authorized for common stock for equity awards | 466,666 | |||||||
Number of shares available for future issuance | 838,659 | 838,659 | ||||||
Common stock purchased | 226,500 | 922,096 | ||||||
Restricted stock units granted | 181,945 | 556,822 | ||||||
2020 Equity Incentive Plan [Member] | Maximum [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of additional shares authorized for common stock for equity awards | 325,268 | |||||||
2021 Employee Stock Purchase Plan [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of shares authorized for common stock for equity awards | 73,525 | |||||||
Number of shares available for future issuance | 426,503 | 426,503 | ||||||
Amended and Restated 2020 Plan [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of additional shares authorized for common stock for equity awards | 866,666 | |||||||
Number of share reserved for future issuance | 1,533,333 | |||||||
Percentage of number of shares outstanding | 5% | |||||||
Amendment and Restatement of ESPP [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of additional shares authorized for common stock for equity awards | 73,525 | |||||||
Number of share reserved for future issuance | 473,525 | |||||||
Percentage of number of shares outstanding | 1% | |||||||
Amendment and Restatement of ESPP [Member] | Minimum [Member] | ||||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||
Number of additional shares authorized for common stock for equity awards | 293,597 |
Equity-Based Compensation - Sch
Equity-Based Compensation - Schedule of Equity-based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock-based compensation expense | $ 1,944 | $ 1,814 | $ 4,062 | $ 4,426 |
Research and Development [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock-based compensation expense | 710 | 394 | 1,608 | 1,574 |
General and Administrative [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock-based compensation expense | $ 1,234 | $ 1,420 | $ 2,454 | $ 2,852 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Detail) - USD ($) | 3 Months Ended | 6 Months Ended | |||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2022 | |
Income Tax Disclosure [Abstract] | |||||
Income tax expense (benefit) | $ 0 | $ 0 | $ 0 | $ 0 | |
Unrecognized tax benefits | $ 0 | $ 0 | $ 0 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands | Jun. 30, 2023 | Dec. 31, 2022 |
Office and Laboratory Lease [Member] | ||
Commitment And Contingencies [Line Items] | ||
Letter of credit outstanding amount | $ 1,833 | $ 1,833 |
Net Loss per Share - Schedule o
Net Loss per Share - Schedule of Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | |
Earnings Per Share Basic [Line Items] | ||||
Net loss attributable to common stockholders | $ (24,629) | $ (25,092) | $ (54,699) | $ (50,420) |
Weighted average shares of common stock outstanding, basic | 19,663,672 | 7,523,964 | 19,618,517 | 7,515,673 |
Weighted average shares of common stock outstanding, diluted | 19,663,672 | 7,523,964 | 19,618,517 | 7,515,673 |
Net loss per share attributable to common stockholders, basic | $ (1.25) | $ (3.33) | $ (2.79) | $ (6.71) |
Net loss per share attributable to common stockholders, diluted | $ (1.25) | $ (3.33) | $ (2.79) | $ (6.71) |
Common Stock [Member] | ||||
Earnings Per Share Basic [Line Items] | ||||
Weighted average shares of common stock outstanding, basic | 19,663,672 | 7,523,964 | ||
Weighted average shares of common stock outstanding, diluted | 19,663,672 | 7,523,964 |
Net Loss per Share - Schedule_2
Net Loss per Share - Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share Attributable to Common Stockholders (Detail) - shares | 6 Months Ended | |
Jun. 30, 2023 | Jun. 30, 2022 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Common stock equivalents excluded from calculation of diluted net loss per share | 3,193,408 | 1,946,525 |
Options to Purchase Shares of Common Stock [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Common stock equivalents excluded from calculation of diluted net loss per share | 2,229,684 | 1,433,968 |
Unvested Restricted Stock Units [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Common stock equivalents excluded from calculation of diluted net loss per share | 963,724 | 512,557 |
Restructuring - Addition Inform
Restructuring - Addition Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | |||||
Nov. 30, 2022 | Apr. 30, 2022 | Jun. 30, 2023 | Dec. 31, 2022 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2022 | Mar. 31, 2024 | |
Restructuring Cost and Reserve [Line Items] | |||||||||
Restructuring charges | $ (63) | $ 1,520 | $ (63) | $ 1,520 | |||||
April 2022 Plan [Member] | |||||||||
Restructuring Cost and Reserve [Line Items] | |||||||||
Number of headcount reduced, percentage | 35% | ||||||||
Restructuring charges related to severance payment and other employee-related costs | $ 1,520 | ||||||||
November 2022 Plan [Member] | |||||||||
Restructuring Cost and Reserve [Line Items] | |||||||||
Number of headcount reduced, percentage | 18% | ||||||||
Restructuring charges related to severance payment and other employee-related costs | $ 5,658 | ||||||||
Restructuring charges were paid | $ 2,903 | $ 1,737 | |||||||
November 2022 Plan [Member] | Forcast [Member] | |||||||||
Restructuring Cost and Reserve [Line Items] | |||||||||
Restructuring charges expected to be paid | $ 1,018 |
Restructuring - Schedule of Acc
Restructuring - Schedule of Accrued Restructuring Charges (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended | ||
Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2022 | |
Restructuring Cost and Reserve [Line Items] | |||||
Accrual recorded as a result of restructuring charges | $ (63) | $ 1,520 | $ (63) | $ 1,520 | |
One-Time Employee Termination Benefits [Member] | April 2022 Corporate Strategy Change [Member] | |||||
Restructuring Cost and Reserve [Line Items] | |||||
Accrual recorded as a result of restructuring charges | $ 1,520 | ||||
Amounts paid during the period | (1,520) | ||||
One-Time Employee Termination Benefits [Member] | November 2022 Workforce Reduction plan [Member] | |||||
Restructuring Cost and Reserve [Line Items] | |||||
Accrued restructuring charges, beginning balance | 3,921 | ||||
Accrual recorded as a result of restructuring charges | 5,658 | ||||
Amounts paid during the period | (2,903) | (1,737) | |||
Accrued restructuring charges, ending balance | $ 1,018 | $ 1,018 | $ 3,921 |