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Exhibit 21.1
The following is a list of our significant subsidiaries:
Company | Country of Incorporation |
| Ultimate Ownership by Parent | |
Orthofix Australia Pty. Ltd. | Australia |
| 100% | |
Orthofix do Brasil Ltda. | Brazil |
| 100% | |
Orthofix S.A. | France |
| 100% | |
Orthofix GmbH | Germany |
| 100% | |
Orthofix Spine GmbH | Germany |
| 100% | |
Orthofix S.r.l. | Italy |
| 100% | |
Orthofix Netherlands B.V. | Netherlands |
| 100% | |
Implantes y Sistemas Medicos, Inc. | Puerto Rico |
| 100% | |
Orthofix AG |
| Switzerland |
| 100% |
Orthofix Limited | UK |
| 100% | |
Orthofix US LLC | US |
| 100% | |
Spinal Kinetics, LLC | US |
| 100% | |
SeaSpine Holdings Corporation |
| US |
| 100% |
IsoTis International SARL |
| Switzerland |
| 100% |
IsoTis OrthoBiologics, Inc. |
| US |
| 100% |
IosTis, Inc. |
| US |
| 100% |
SeaSpine, Inc. |
| US |
| 100% |
SeaSpine Sales LLC |
| US |
| 100% |
SeaSpine Orthopedics Corporation |
| US |
| 100% |
Theken Spine, LLC |
| US |
| 100% |
SeaSpine Orthopedics IntermediateCo, Inc. |
| US |
| 100% |
Project Maple Leaf Holdings ULC |
| British Columbia |
| 100% |
7D Surgical ULC |
| British Columbia |
| 100% |
7D Surgical USA Inc. |
| US |
| 100% |
7D Surgical International Inc. |
| Barbados |
| 100% |