Document and Entity Information
Document and Entity Information - shares | 3 Months Ended | |
Mar. 31, 2020 | May 14, 2020 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Mar. 31, 2020 | |
Document Fiscal Year Focus | 2020 | |
Document Fiscal Period Focus | Q1 | |
Document Transition Report | false | |
Document Quarterly Report | true | |
Trading Symbol | ACHV | |
Entity Incorporation, State or Country Code | DE | |
Entity Registrant Name | Achieve Life Sciences, Inc. | |
Entity Central Index Key | 0000949858 | |
Current Fiscal Year End Date | --12-31 | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Non-accelerated Filer | |
Entity Shell Company | false | |
Entity Small Business | true | |
Entity Emerging Growth Company | false | |
Entity File Number | 033-80623 | |
Entity Tax Identification Number | 95-4343413 | |
Entity Address, Address Line One | 1040 West Georgia Street | |
Entity Address, Address Line Two | Suite 1030 | |
Entity Address, City or Town | Vancouver | |
Entity Address, State or Province | BC | |
Entity Address, Country | CA | |
Entity Address, Postal Zip Code | V6E 4H1 | |
City Area Code | 604 | |
Local Phone Number | 210-2217 | |
Entity Common Stock, Shares Outstanding | 37,515,408 | |
Title of 12(b) Security | Common Stock, par value $0.001 per share | |
Security Exchange Name | NASDAQ |
Consolidated Balance Sheets (Un
Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Current assets: | ||
Cash and cash equivalents [note 5] | $ 12,156 | $ 16,664 |
Amounts receivable | 8 | |
Prepaid expenses and other assets | 746 | 662 |
Total current assets | 12,902 | 17,334 |
Restricted cash [note 5] | 50 | 50 |
Property and equipment, net | 52 | 57 |
Right-of-use assets [note 7] | 285 | 329 |
Other assets | 293 | 187 |
License agreement [note 3 and 4] | 2,031 | 2,087 |
Goodwill [note 4] | 1,034 | 1,034 |
Total assets | 16,647 | 21,078 |
Current liabilities: | ||
Accounts payable | 184 | 859 |
Accrued liabilities other | 174 | 304 |
Accrued clinical liabilities | 571 | 387 |
Accrued compensation | 419 | 1,116 |
Current portion of long-term obligations [note 7] | 196 | 203 |
Total current liabilities | 1,544 | 2,869 |
Long-term obligations [note 7] | 118 | 159 |
Total liabilities | 1,662 | 3,028 |
Commitments and contingencies [note 7] | ||
Stockholders' equity: | ||
Common stock, $0.001 par value, 150,000,000 shares authorized, 31,352,764 issued and outstanding at March 31, 2020 and 29,485,178 issued and outstanding at December 31, 2019, respectively. | 43 | 41 |
Additional paid-in capital | 63,962 | 63,709 |
Accumulated deficit | (49,024) | (45,704) |
Accumulated other comprehensive income | 4 | 4 |
Total stockholders' equity | 14,985 | 18,050 |
Total liabilities and stockholders' equity | 16,647 | 21,078 |
Series A Convertible Preferred Stock [Member] | ||
Stockholders' equity: | ||
Convertible preferred stock, value | ||
Series B Convertible Preferred Stock [Member] | ||
Stockholders' equity: | ||
Convertible preferred stock, value |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) (Unaudited) - $ / shares | Mar. 31, 2020 | Dec. 31, 2019 |
Preferred stock, par value | $ 0.001 | |
Common stock, par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 150,000,000 | 150,000,000 |
Common stock, shares issued | 31,352,764 | 29,485,178 |
Common stock, shares outstanding | 31,352,764 | 29,485,178 |
Series A Convertible Preferred Stock [Member] | ||
Preferred stock, par value | $ 0.001 | $ 0.001 |
Preferred stock, shares designated | 9,158 | 9,158 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Series B Convertible Preferred Stock [Member] | ||
Preferred stock, par value | $ 0.001 | $ 0.001 |
Preferred stock, shares designated | 6,256 | 6,256 |
Preferred stock, shares issued | 0 | 1,121 |
Preferred stock, shares outstanding | 0 | 1,121 |
Consolidated Statements of Loss
Consolidated Statements of Loss and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
EXPENSES | ||
Research and development | $ 1,541 | $ 4,055 |
General and administrative | 1,816 | 1,885 |
Total operating expenses | 3,357 | 5,940 |
OTHER INCOME (EXPENSE) | ||
Interest income | 42 | 62 |
Other expenses | (5) | (26) |
Total other income (expense) | 37 | 36 |
Net loss | (3,320) | (5,904) |
Comprehensive loss | $ (3,320) | $ (5,904) |
Basic and diluted net loss per common share | $ (0.11) | $ (0.88) |
Weighted average shares used in computation of basic and diluted net loss per common share | 30,936,777 | 6,721,184 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | 31 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | Mar. 31, 2020 | |
Operating Activities: | |||
Net loss | $ (3,320) | $ (5,904) | |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Depreciation and amortization [note 3] | 61 | 65 | |
Stock-based compensation [note 6 [c] and note 6 [d]] | 302 | 290 | |
Changes in operating assets and liabilities: | |||
Amounts receivable | 8 | ||
Prepaid expenses and other assets | (190) | 88 | |
Accounts payable | (675) | 550 | |
Accrued liabilities other | (130) | (199) | |
Accrued clinical liabilities | 184 | 887 | |
Accrued compensation | (697) | (680) | |
Lease obligation [note 7] | (4) | 14 | |
Net cash used in operating activities | (4,461) | (4,889) | |
Financing Activities: | |||
Net cash used in financing activities | (47) | ||
Investing Activities: | |||
Purchase of property and equipment | (2) | (54) | |
Purchase of investments | (20) | ||
Proceeds from maturities of investments | 2,764 | ||
Net cash provided by (used in) investing activities | (2) | 2,690 | |
Effect of exchange rate changes on cash | 2 | 4 | |
Net increase (decrease) in cash, cash equivalents and restricted cash | (4,508) | (2,195) | |
Cash, cash equivalents and restricted cash at beginning of the period | 16,714 | 9,565 | |
Cash, cash equivalents and restricted cash at end of the period | 12,206 | $ 7,370 | $ 12,206 |
LPC [Member] | |||
Financing Activities: | |||
Costs relating to registered direct offering and purchase agreement | $ (500) | ||
LPC [Member] | Purchase Agreement [Member] | |||
Financing Activities: | |||
Costs relating to registered direct offering and purchase agreement | (13) | ||
December 2019 Registered Direct Offering [Member] | |||
Financing Activities: | |||
Costs relating to registered direct offering and purchase agreement | $ (34) |
Consolidated Statements of Stoc
Consolidated Statements of Stockholder's Equity (Unaudited) - USD ($) $ in Thousands | Total | LPC [Member] | December 2019 Financing [Member] | October 2018 Financing [Member] | Common stock [Member] | Common stock [Member]Series B Convertible Preferred Stock [Member] | Preferred stock [Member] | Preferred stock [Member]Series B Convertible Preferred Stock [Member] | Additional paid-in capital [Member] | Additional paid-in capital [Member]Series B Convertible Preferred Stock [Member] | Additional paid-in capital [Member]LPC [Member] | Additional paid-in capital [Member]December 2019 Financing [Member] | Additional paid-in capital [Member]October 2018 Financing [Member] | Accumulated other comprehensive income (loss) [Member] | Accumulated deficit [Member] |
Beginning Balance at Dec. 31, 2018 | $ 15,802 | $ 18 | $ 41,161 | $ 4 | $ (25,381) | ||||||||||
Beginning Balance, Shares at Dec. 31, 2018 | 6,721,117 | 579 | |||||||||||||
Restricted stock unit settlements, Shares | 133 | 83 | |||||||||||||
Stock-based compensation expense | $ 290 | 290 | |||||||||||||
Adjustments to final October 2018 financing costs | $ 4 | $ 4 | |||||||||||||
Cumulative adjustment on adoption of lease standard | ASU 2016-02 [Member] | (3) | (3) | |||||||||||||
Net loss | (5,904) | (5,904) | |||||||||||||
Ending Balance at Mar. 31, 2019 | 10,189 | $ 18 | 41,455 | 4 | (31,288) | ||||||||||
Ending Balance, Shares at Mar. 31, 2019 | 6,721,200 | 579 | |||||||||||||
Beginning Balance at Dec. 31, 2019 | $ 18,050 | $ 41 | 63,709 | 4 | (45,704) | ||||||||||
Beginning Balance, Shares at Dec. 31, 2019 | 29,485,178 | 1,121 | |||||||||||||
Restricted stock unit settlements, Shares | 0 | ||||||||||||||
Stock-based compensation expense | $ 302 | 302 | |||||||||||||
Costs relating to financing and purchase agreement | $ (13) | $ (34) | $ (13) | $ (34) | |||||||||||
Shares issued on conversion of preferred shares | $ 2 | $ (2) | |||||||||||||
Shares issued on conversion of preferred shares, Shares | 1,867,586 | (1,121) | |||||||||||||
Net loss | (3,320) | (3,320) | |||||||||||||
Ending Balance at Mar. 31, 2020 | $ 14,985 | $ 43 | $ 63,962 | $ 4 | $ (49,024) | ||||||||||
Ending Balance, Shares at Mar. 31, 2020 | 31,352,764 |
Nature of Business, Basis of Pr
Nature of Business, Basis of Presentation and Going Concern Uncertainty | 3 Months Ended |
Mar. 31, 2020 | |
Accounting Policies [Abstract] | |
Nature of Business, Basis of Presentation and Going Concern Uncertainty | 1. NATURE OF BUSINESS, BASIS OF PRESENTATION AND GOING CONCERN UNCERTAINTY Achieve Life Sciences, Inc. (referred to as “Achieve,” “we,” “us,” or “our”) is a clinical-stage pharmaceutical company committed to the global development and commercialization of cytisinicline for smoking cessation. We were incorporated in the state of Delaware, and operate out of Vancouver, British Columbia and Seattle, Washington. The unaudited consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States, or U.S. GAAP, for interim financial information and with the instructions to Form 10-Q. Accordingly, they do not include all of the information and footnotes required to be presented for complete financial statements. The accompanying unaudited consolidated financial statements reflect all adjustments (consisting only of normal recurring items) which are, in the opinion of management, necessary for a fair presentation of the results for the interim periods presented. The accompanying consolidated Balance Sheet at December 31, 2019 has been derived from the audited consolidated financial statements included in our Annual Report on Form 10-K for the year then ended. The unaudited consolidated financial statements and related disclosures have been prepared with the assumption that users of the interim financial information have read or have access to the audited consolidated financial statements for the preceding fiscal year. Accordingly, these financial statements should be read in conjunction with the audited consolidated financial statements and the related notes thereto included in the Annual Report on Form 10-K for the year ended December 31, 2019 and filed with the United States Securities and Exchange Commission, or the SEC, on March 13, 2020. The consolidated financial statements include the accounts of Achieve and our wholly owned subsidiaries, Achieve Life Sciences Technologies Inc., Achieve Life Science, Inc., Extab Corporation, and Achieve Pharma UK Limited. All intercompany balances and transactions have been eliminated. Going Concern Uncertainty The accompanying financial statements have been prepared assuming we will continue to operate as a going concern, which contemplates the realization of assets and liabilities and commitments in the normal course of business. We have historically experienced recurring losses from operations that have generated an accumulated deficit of $49.0 million through March 31, 2020. During the three months ended March 31, 2020, we incurred a net loss of $3.3 million. Substantial doubt exists as to our ability to continue as a going concern. Our ability to continue as a going concern is uncertain and dependent on our ability to obtain additional financing. There is no assurance that we will obtain financing from other sources. We have, thus far, financed our operations through the closing of the arrangement between us and OncoGenex Pharmaceuticals, Inc. pursuant to a Merger Agreement dated January 5, 2017, or the Arrangement, and through debt and equity financings (Note 6—Common Stock . Our current resources are insufficient to fund our planned operations for the next 12 months. We will continue to require substantial additional capital to continue our clinical development activities. Accordingly, we will need to raise substantial additional capital to continue to fund our operations from the sale of our securities, partnering arrangements or other financing transactions in order to finance the commercialization of our product candidate. The amount and timing of our future funding requirements will depend on many factors, including the pace and results of our clinical development efforts. Failure to raise capital as and when needed, on favorable terms or at all, will have a negative impact on our financial condition and our ability to develop our product candidate. The uncertainty with respect to our operations and the market generally due to the COVID-19 pandemic may also make it challenging to raise additional capital on favorable terms, if at all. We expect our research and development expenses to substantially increase in connection with our ongoing activities, particularly as we advance our product candidate in clinical development . The consolidated financial statements do not include any adjustments to the amounts and classification of assets and liabilities that might be necessary should we be unable to continue as a going concern. Such adjustments could be material . |
Accounting Policies
Accounting Policies | 3 Months Ended |
Mar. 31, 2020 | |
Accounting Policies [Abstract] | |
Accounting Policies | 2. ACCOUNTING POLICIES The preparation of financial statements in accordance with U.S. GAAP requires management to make estimates and assumptions that affect reported amounts and related disclosures. We have discussed those estimates that we believe are critical and require the use of complex judgment in their application in our audited financial statements for the year ended December 31, 2019 in our Annual Report on Form 10-K filed with the SEC, on March 13, 2020. Since December 31, 2019, there have been no material changes to our critical accounting policies or the methodologies or assumptions we apply under them. |
Intangibles
Intangibles | 3 Months Ended |
Mar. 31, 2020 | |
Goodwill And Intangible Assets Disclosure [Abstract] | |
Intangibles | 3. INTANGIBLES All of our intangible assets are subject to amortization and are amortized using the straight-line method over their estimated useful life. We acquired license and supply agreements in relation to cytisinicline upon the acquisition of Extab Corporation, or Extab, on May 18, 2015. The agreements were determined to have a fair value of $3.1 million with an estimated useful life of 14 years. The components of intangible assets were as follows: March 31, 2020 December 31, 2019 Gross Carrying Accumulated Net Carrying Gross Carrying Accumulated Net Carrying Value Amortization Value Value Amortization Value License Agreements $ 3,117 $ (1,086 ) $ 2,031 $ 3,117 $ (1,030 ) $ 2,087 For the three months ended March 31, 2020, March 31, 2019, March 31, 2020 Year Ending December 31, 2020 $ 167 2021 223 2022 223 2023 223 Thereafter 1,195 Total $ 2,031 We evaluate the carrying amount of intangible assets periodically by taking into account events or circumstances that may warrant revised estimates of useful life or that indicate the asset may be impaired. We conducted an analysis of potential impairment indicators for long lived assets, including the license and supply agreements for the active pharmaceutical ingredient cytisinicline, and concluded no impairment had occurred as of March 31, 2020 |
License Agreements
License Agreements | 3 Months Ended |
Mar. 31, 2020 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
License Agreements | 4. LICENSE AGREEMENTS Sopharma License and Supply Agreements In 2009 and 2010, we entered into a license agreement, or the Sopharma License Agreement, and a supply agreement, or the Sopharma Supply Agreement, with Sopharma, AD, or Sopharma. Pursuant to the Sopharma License Agreement, we were granted access to all available manufacturing, efficacy and safety data related to cytisinicline, as well as a granted patent in several European countries including Germany, France and Italy related to new oral dosage forms of cytisinicline providing enhanced stability. Additional rights granted under the Sopharma License Agreement include the exclusive use of, and the right to sublicense, the trademark Tabex in all territories—other than certain countries in Central and Eastern Europe, Scandinavia, North Africa, the Middle East and Central Asia, as well as Vietnam A cross-license exists between us and Sopharma whereby we grant to Sopharma rights to any patents or patent applications or other intellectual property rights filed by us in Sopharma territories. On May 14, 2015, we and Sopharma entered into an amendment to the Sopharma License Agreement. Among other things, the amendment to the Sopharma License Agreement reduced the royalty payments payable by us to Sopharma from a percentage in the mid-teens to a percentage in the mid-single digits and extended the term of the Sopharma License Agreement until May 26, 2029. On July 28, 2017, we and Sopharma entered into the amended and restated Sopharma Supply Agreement. Pursuant to the amended and restated Sopharma Supply Agreement, for territories as detailed in the licensing agreement, we will exclusively purchase all of our cytisinicline from Sopharma, and Sopharma agrees to exclusively supply all such cytisinicline requested by us, and we extended the term to 2037. In addition, we will have full access to the cytisinicline supply chain and Sopharma will manufacture sufficient cytisinicline to meet a forecast for a specified demand of cytisinicline for the five years commencing shortly after the commencement of the agreement, with the forecast to be updated regularly thereafter. Each of us and Sopharma may terminate the Sopharma Supply Agreement in the event of the other party’s material breach or bankruptcy or insolvency. University of Bristol License Agreement In July 2016, we entered into a license agreement with the University of Bristol, or the University of Bristol License Agreement. Under the University of Bristol License Agreement, we received exclusive and nonexclusive licenses from the University of Bristol to certain patent and technology rights resulting from research activities into cytisinicline and its derivatives for use in smoking cessation, including a number of patent applications related to novel approaches to cytisinicline binding at the nicotinic receptor level. Any patents issued in connection with these applications would be scheduled to expire on February 5, 2036 at the earliest. In consideration of rights granted by the University of Bristol, we agreed to pay amounts of up to $3.2 million, in the aggregate, tied to a financing milestone and to specific clinical development and commercialization milestones resulting from activities covered by the University of Bristol License Agreement. Additionally, if we successfully commercialize product candidates subject to the University of Bristol License Agreement, we are responsible for royalty payments in the low-single digits and payments up to a percentage in the mid-teens of any sublicense income, subject to specified exceptions, based upon net sales of such licensed products. On January 22, 2018, we and the University of Bristol entered into an amendment to the University of Bristol License Agreement. Pursuant to the amended University of Bristol License Agreement, we received exclusive rights for all human medicinal uses of cytisinicline across all therapeutic categories from the University of Bristol from research activities into cytisinicline and its derivatives. In consideration of rights granted by the amended University of Bristol License Agreement, we agreed to pay an initial amount of $37,500 upon the execution of the amended University of Bristol License Agreement, and additional amounts of up to $1.7 million, in the aggregate, tied to a financing milestone and to specific clinical development and commercialization milestones resulting from activities covered by the amended University of Bristol License Agreement, in addition to amounts under the original University of Bristol License Agreement of up to $3.2 million in the aggregate, tied to specific financing, development and commercialization milestones. Additionally, if we successfully commercialize any product candidate subject to the amended University of Bristol License Agreement or to the original University of Bristol License Agreement, we will be responsible, as provided in the original University of Bristol License Agreement, for royalty payments in the low-single digits and payments up to a percentage in the mid-teens of any sublicense income, subject to specified exceptions, based upon net sales of such licensed products. Up to March 31, 2020, we had paid the University of Bristol $125,000 pursuant to the University of Bristol License Agreement. Unless otherwise terminated, the University of Bristol License Agreement will continue until the earlier of July 2036 or the expiration of the last patent claim subject to the University of Bristol License Agreement. We may terminate the University of Bristol License Agreement for convenience upon a specified number of days’ prior notice to the University of Bristol. The University of Bristol License Agreement will terminate under customary termination provisions including bankruptcy or insolvency or its material breach of the agreement. Under the terms of the University of Bristol License Agreement, we provided 100 grams of cytisinicline to the University of Bristol as an initial contribution. |
Fair Value Measurements
Fair Value Measurements | 3 Months Ended |
Mar. 31, 2020 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | 5. FAIR VALUE MEASUREMENTS Assets and liabilities recorded at fair value in the balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair value. For certain of our financial instruments including amounts receivable and accounts payable the carrying values approximate fair value due to their short-term nature. ASC 820 “Fair Value Measurements and Disclosures” specifies a hierarchy of valuation techniques based on whether the inputs to those valuation techniques are observable or unobservable. In accordance with ASC 820, these inputs are summarized in the three broad levels listed below: • Level 1 – Quoted prices in active markets for identical securities. • Level 2 – Other significant inputs that are observable through corroboration with market data (including quoted prices in active markets for similar securities). • Level 3 – Significant unobservable inputs that reflect management’s best estimate of what market participants would use in pricing the asset or liability. As quoted prices in active markets are not readily available for certain financial instruments, we obtain estimates for the fair value of financial instruments through third-party pricing service providers. In determining the appropriate levels, we performed a detailed analysis of the assets and liabilities that are subject to ASC 820. We invest our excess cash in accordance with investment guidelines that limit the credit exposure to any one financial institution other than securities issued by the U.S. Government. These securities are not collateralized and mature within one year. A description of the valuation techniques applied to our financial instruments measured at fair value on a recurring basis follows. Financial Instruments Cash Significant amounts of cash are held on deposit with large well-established U.S. and Canadian financial institutions. Money Market Securities Money market securities are classified within Level I of the fair value hierarchy and are valued based on quoted prices in active markets for identical securities. The following table presents information about our assets that are measured at fair value on a recurring basis, and indicates the fair value hierarchy of the valuation techniques we utilized to determine such fair value (in thousands): March 31, 2020 Level 1 Level 2 Level 3 Total Assets Cash $ 550 $ — $ — $ 550 Money market securities (cash equivalents) 11,606 — — 11,606 Restricted cash 50 — — 50 Total assets $ 12,206 $ — $ — $ 12,206 Cash and cash equivalents consist of the following (in thousands): Gross Gross Unrealized Unrealized Estimated March 31, 2020 Cost Gains Losses Fair Value Cash $ 550 $ — $ — $ 550 Money market securities 11,606 — — 11,606 Total cash and cash equivalents $ 12,156 $ — $ — $ 12,156 Money market securities (restricted cash) 50 — — 50 Total restricted cash $ 50 $ — $ — $ 50 We only invest in A (or equivalent) rated securities. All securities included in cash and cash equivalents had maturities of 90 days or less at the time of purchase. |
Common Stock
Common Stock | 3 Months Ended |
Mar. 31, 2020 | |
Equity [Abstract] | |
Common Stock | 6. COMMON STOCK [a] Authorized 150,000,000 authorized common shares, par value of $0.001, and 5,000,000 preferred shares, par value of $0.001. [b] Issued and outstanding shares Purchase Agreement and Financing with Lincoln Park Capital On September 14, 2017 we and Lincoln Park Capital Fund, LLC, or LPC, entered into a share and unit purchase agreement, or Purchase Agreement, pursuant to which we have the right to sell to LPC up to $11.0 million in shares of our common stock, par value $0.001 per share, subject to certain limitations and conditions set forth in the Purchase Agreement. On May 22, 2018 we obtained the requisite stockholder authorization to sell shares of our common stock to LPC in excess of 20% of our outstanding shares of common stock (as of the date we entered into the purchase agreement) in order to be able to sell to LPC the full amount remaining under the purchase agreement. Pursuant to the Purchase Agreement, LPC initially purchased 32,895 of our units, or the Units, at a purchase price of $30.40 per unit, with each Unit consisting of (a) one share of our Common Stock and (b) one warrant to purchase one-quarter of a share of Common Stock at an exercise price of $34.96 per share, or Warrant. Each Warrant is exercisable six months following the issuance date until the date that is five years and six months after the issuance date and is subject to customary adjustments. The Warrants were issued only as part of the Units in the initial purchase of $1.0 million and no warrants shall be issued in connection with any other purchases of common stock under the Purchase Agreement. After the initial purchase, if our stock price is above $1.00, as often as every other business day over the 30-month term of the Purchase Agreement, and up to an aggregate amount of an additional $10.0 million (subject to certain limitations) of shares of common stock, we have the right, from time to time, in our sole discretion and subject to certain conditions to direct LPC to purchase up to 8,000 shares of common stock with such amounts increasing as the closing sale price of our common stock as reported on The Nasdaq Capital Market increases. The purchase price of shares of common stock pursuant to the Purchase Agreement will be based on prevailing market prices of common stock at the time of sales without any fixed discount, and we will control the timing and amount of any sales of common stock to LPC. In addition, we may direct LPC to purchase additional amounts as accelerated purchases if on the date of a regular purchase the closing sale price of the common stock is not below $20.00 per share. As consideration for entering into the Purchase Agreement, we issued to LPC 12,352 shares of common stock; no cash proceeds were received from the issuance of these shares. The consideration of 12,352 shares of our common stock were fair valued based on the closing price of our common stock as at the transaction date and recognized as part of offering expenses. During the three months ended March 31, 2020, we offered and sold zero shares of our common stock pursuant to the Purchase Agreement with LPC. Since entry into the Purchase Agreement, from September 14, 2017 through March 31, 2020, we offered and sold an aggregate of 557,378 shares of our common stock, including the 32,895 shares that were part of the initial purchase of Units. These aggregate sales resulted in gross proceeds to us of approximately $4.4 million and offering expenses of $0.5 million. On March 12, 2020, we and LPC entered into Amendment No. 1 to the Purchase Agreement, or the Amendment, pursuant to which the term of the Purchase Agreement was extended from 30 months to 54 months and the number of shares of common stock that we may direct LPC to purchase from time to time pursuant to a Regular Purchase (as defined in the Purchase Agreement) was increased from 80,000 shares of common stock to 150,000 shares of common stock. Minimum closing stock price requirements were also removed for Regular Purchases and Accelerated Purchases (each as defined in the Purchase Agreement). In connection with the Amendment, we agreed to pay to LPC $0.1 million as an expense reimbursement. At The Market Offering Agreement with H.C. Wainwright & Co., LLC On June 7, 2019, we entered into an At The Market Offering Agreement, or the Offering Agreement, with H.C. Wainwright & Co., LLC, as agent, or H.C. Wainwright, pursuant to which we may offer and sell, from time to time and at our election, through H.C. Wainwright shares of our common stock, par value $0.001 per share, having an aggregate offering price of up to $6.0 million. Pursuant to the Offering Agreement, H.C. Wainwright may sell the shares our common stock by any method permitted by law deemed to be an “at the market offering” as defined in Rule 415 of the Securities Act, including sales made by means of ordinary brokers’ transactions, including on The Nasdaq Capital Market, at market prices or as otherwise agreed with H.C. Wainwright. H.C. Wainwright will use commercially reasonable efforts consistent with its normal trading and sales practices to sell the shares of common stock from time to time, based upon instructions from us, including any price or size limits or other customary parameters or conditions we may impose. We are not obligated to make any sales of the shares of common stock under the Offering Agreement. The offering of shares of common stock pursuant to the Offering Agreement will terminate upon the earliest of (a) the sale of all of the shares of common stock subject to the Offering Agreement, (b) the termination of the Offering Agreement by H.C. Wainwright or us, as permitted therein, or (c) June 7, 2022. We will pay H.C. Wainwright a commission rate equal to 3.0% of the aggregate gross proceeds from each sale of shares of common stock and have agreed to provide H.C. Wainwright with customary indemnification and contribution rights. We will also reimburse H.C. Wainwright for certain specified expenses in connection with entering into the Offering Agreement. The Offering Agreement contains customary representations and warranties and conditions to the placements of the shares of common stock pursuant thereto. From June 7, 2019 to March 31, 2020 we did not offer any shares of our common stock for sale pursuant to the Offering Agreement. As of March 31, 2019, shares of our common stock having an aggregate value of approximately $6.0 million remained available for sale under the Offering Agreement. The offering expenses and fees have been deferred and will be charged against gross proceeds. December 2019 Public Offering On December 17, 2019, we completed an underwritten registered public offering, pursuant to which we sold, 9,577,504 Class A Units at a price per unit of $0.60 and 6,256 Class B Units at a price per unit of $999.60. Each Class A Unit consisted of one share of our common stock and a warrant to purchase one share of common stock. Each Class B Unit consisted of one share of Series B Convertible Preferred Stock, par value $0.001 per share, convertible at any time at the holder’s option into 1,666 shares of common stock, and warrants to purchase 1,666 shares of common stock. Each warrant was immediately exercisable, expires on the five year anniversary of the date of issuance and is exercisable at a price per share of common stock of $0.60, subject to adjustment in the event of subsequent equity sales of common stock or securities convertible into common stock for an exercise price per share less than the exercise price per share of the warrants then in effect, provided, however, that the exercise price of the warrants cannot be reduced to an amount less than $0.06 per share of common stock. Additionally, subject to certain exceptions, if, after December 17, 2019, (i) the volume weighted average price of the common stock for each of 30 consecutive trading days, or the 2019 Measurement Period, which 2019 Measurement Period commences on the closing date, exceeds 300% of the exercise price (subject to adjustments for stock splits, recapitalizations, stock dividends and similar transactions), (ii) the average daily trading volume for such 2019 Measurement Period exceeds $500,000 per trading day and (iii) certain other equity conditions are met, and subject to a beneficial ownership limitation, then the Company may call for cancellation of all or any portion of the warrants then outstanding. The Class A Units and Class B Units were not certificated and the shares of common stock, Series B Convertible Preferred Stock and warrants comprising such Units were immediately separable and were issued separately in the public offering. The Class A and B Units were offered by us pursuant to the registration statement on Form S-1 (File No. 333-234530), and each amendment thereto, which was initially filed with the SEC on November 6, 2019 and declared effective by the SEC on December 17, 2019. In addition, pursuant to the Underwriting Agreement we entered into with Ladenburg Thalmann & Co. Inc., or Ladenburg, on December 17, 2019, we granted Ladenburg a 45 day option, or the 2019 Overallotment Option, to purchase up to 3,000,000 additional shares of common stock and/or warrants to purchase up to 3,000,000 shares of common stock solely to cover over-allotments. The 2019 Overallotment Option was exercised in full on December 17, 2019. The public offering raised total gross proceeds of $13.8 million and after deducting $1.5 million in underwriting discounts and commissions and offering expenses, we received net proceeds of $12.3 million. The underwriting discounts and commissions and offering expenses have been charged against the gross proceeds. As of March 31, 2020, all 6,256 shares of the Series B Convertible Preferred Stock had been converted into 10,422,496 shares of common stock, and no shares of the Series B Convertible Preferred Stock remained outstanding. Equity Award Issuances and Settlements During the three months ended March 31, 2020, we issued no shares of common stock to satisfy stock options exercises and no shares of common stock to satisfy restricted stock unit settlements, compared with no shares of common stock issued to satisfy stock options exercises and 133 shares of common stock to satisfy restricted stock unit settlements, during the three month period ended March 31, 2019. [c] Stock options 2018 Equity Incentive Plan As of March 31, 2020, we had reserved, pursuant to the 2018 Equity Incentive Plan, or the 2018 Plan, 2,810,314 common shares for issuance upon exercise of stock options by employees, directors, officers and consultants of ours, of which 2,216,105 were reserved for options currently outstanding and 594,209 were available for future equity grants. Under the 2018 Plan, we may grant options to purchase common shares or restricted stock units to our employees, directors, officers and consultants. The exercise price of the options is determined by our board of directors but will be at least equal to the fair value of the common shares at the grant date. The options vest in accordance with terms as determined by our board of directors, typically over three to four years for options issued to employees and consultants, and over one to three years for members of our board of directors. The expiry date for each option is set by our board of directors with a maximum expiry date of ten years from the date of grant. In addition, the 2018 Plan allows for accelerated vesting of outstanding equity awards in the event of a change in control. The terms for accelerated vesting, in the event of a change in control, is determined at our discretion and defined under the employment agreements for our officers and certain of our employees. 2017 Equity Incentive Plan As of March 31, 2020 Under the 2017 Plan, we granted options to purchase common shares or restricted stock units to our employees, directors, officers and consultants. The exercise price of the options was determined by our board of directors but was at least equal to the fair value of the common shares at the grant date. The options vest in accordance with terms as determined by our board of directors, typically over three to four years for options issued to employees and consultants, and over one to three years for members of our board of directors. The expiry date for each option was set by our board of directors with a maximum expiry date of ten years from the date of grant. In addition, the 2017 Plan allows for accelerated vesting of outstanding equity awards in the event of a change in control. The terms for accelerated vesting, in the event of a change in control, is determined at our discretion and defined under the employment agreements for our officers and certain of our employees. 2010 Performance Incentive Plan As of March 31, 2020 Under the 2010 Plan we granted options to purchase common shares and restricted stock units to our employees, directors, officers and consultants. The exercise price of the options was determined by our board of directors and was at least equal to the fair value of the common shares at the grant date. The options vest in accordance with terms as determined by our board of directors, typically over three to four years for options issued to employees and consultants, and over one to three years for members of our board of directors. The expiry date for each option is set by our board of directors with a maximum expiry date of ten years from the date of grant. In addition, the 2010 Plan allows for accelerated vesting of outstanding equity awards in the event of a change in control. The terms for accelerated vesting, in the event of a change in control, is determined at our discretion and defined under the employment agreements for our officers and certain of our employees. Stock Option Summary We grant stock options that vest over time in accordance with terms as determined by our Board of Directors, or the Board, which terms are typically four years for employee and consultant grants and one to three years for Board option grants. We also grant stock option awards that vest in conjunction with certain performance conditions to executive officers, employees and consultants. At each reporting date, we are required to evaluate whether achievement of the performance conditions is probable. Compensation expense is recorded over the appropriate service period based upon our assessment of accomplishing each performance condition. The expiry date for each option is set by the Board, which is typically seven to ten years. The exercise price of the options is determined by the Board. Stock option transactions and the number of stock options outstanding are summarized below: Number of Weighted Optioned Average Common Exercise Shares Price Balance, December 31, 2019 1,010,583 $ 10.05 Granted 1,497,600 0.56 Forfeited (18,757 ) 4.33 Balance, March 31, 2020 2,489,426 $ 4.38 The fair value of each stock award for employees and directors is estimated on the grant date and for consultants at each reporting period, using the Black-Scholes option-pricing model based on the weighted-average assumptions noted in the following table: Three Months Ended March 31, 2020 2019 Risk-free interest rates 1.51 % 2.56 % Expected dividend yield 0 % 0 % Expected life 6.02 6.02 Expected volatility 104.06 % 93.72 % The expected life was calculated based on the simplified method as permitted by the SEC’s Staff Accounting Bulletin 110, Share-Based Payment The results for the periods set forth below included share-based compensation expense for stock options and restricted stock units in the following expense categories of the consolidated statements of loss (in thousands): Three Months Ended March 31, 2020 2019 Research and development $ 86 $ 90 General and administrative $ 216 200 Total stock-based compensation $ 302 $ 290 As of March 31,2020, March 31, 2020 For the three months ended March 31, 2020 [d] Restricted Stock Unit Awards We grant restricted stock unit awards that generally vest and are expensed over a four-year period. We also grant restricted stock unit awards that vest in conjunction with certain performance conditions to certain executive officers, key employees and consultants. At each reporting date, we are required to evaluate whether achievement of the performance conditions is probable. Compensation expense is recorded over the appropriate service period based upon our assessment of accomplishing each performance condition. For the three months ended March 31, 2020 The following table summarizes our restricted stock unit award activity during the three months ended March 31, 2020 Weighted Number Average of Grant Date Shares Fair Value Balance, December 31, 2019 10,008 $ 28.99 Forfeited or expired (660 ) 28.90 Balance, March 31, 2020 9,348 $ 29.00 As of March 31, 2020 [e] Non-employee options and restricted stock units We recognize non-employee stock-based compensation expense over the period of expected service by the non-employee. As the service is performed, we are required to update our valuation assumptions, re-measure unvested options and restricted stock units and record the stock-based compensation using the valuation as of the vesting date. This differs from the accounting for employee awards where the fair value is determined at the grant date and is not subsequently adjusted. This re-measurement may result in higher or lower stock-based compensation expense in the Consolidated Statements of Loss and Comprehensive Loss. As such, changes in the market price of our stock could materially change the value of an option or restricted stock unit and the resulting stock-based compensation expense. [f] Common Stock Warrants On May 30, 2019, we entered into a Warrant Exercise Agreement, or the Exercise Agreement, with Armistice Capital Master Fund, Ltd., or Armistice. Pursuant to the Exercise Agreement, Armistice exercised (i) outstanding warrants to purchase 270,313 shares of our common stock, par value $0.001 per share, with an exercise price of $3.1445 per share issued as part of the October 2018 financing and (ii) outstanding warrants to purchase 837,500 shares of our common stock with an exercise price of $4.00 per share issued as part of the June 2018 financing, for aggregate exercise proceeds to us of approximately $4.2 million, or, collectively, the Warrant Exercise. As an inducement for the Warrant Exercise, we agreed to issue to Armistice a new warrant, exercisable for six years, to purchase up to 1,200,000 shares of our common stock at an exercise price of $4.50 per share. We also agreed to file a registration statement covering the resale of the New Warrant Shares. The New Warrant and New Warrant Shares were offered to Armistice in reliance upon the exemption provided by Rule 506 of Regulation D and Section 4(a)(2) of the Securities Act of 1933. Under ASC 260, the fair value of the new warrants of $3.9 million was recognized into accumulated deficit on our consolidated balance sheet. We determined the fair value of the new warrants using the Black-Scholes pricing model with the following assumptions: stock price of $4.23, volatility of 97.16%, risk-free interest rate of 2.06% and expected term of six years. The following is a summary of outstanding warrants to purchase common stock at March 31, 2020 Total Outstanding Exercise and price per Exercisable Share Expiration Date (1) Series A-1 Warrants issued in April 2015 financing 2,175 264.0000 October 2020 (2) Warrants issued in September 2017 financing 8,224 34.9600 March 2023 (3) Warrants issued in June 2018 financing 2,282,000 4.0000 June 2023 (4) Warrants issued in October 2018 financing 624,313 3.1445 October 2023 (5) Warrants issued in May 2019 financing 1,200,000 4.5000 May 2025 (6) Warrants issued in December 2019 financing 23,000,000 0.6000 Dec 2024 No warrants were exercised during the three months ended March 31, 2020 and 2019. As at March 31, 2020, all of our outstanding warrants are classified as equity. |
Commitments and Contingencies
Commitments and Contingencies | 3 Months Ended |
Mar. 31, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 7. COMMITMENTS AND CONTINGENCIES The following table summarizes our contractual obligations as of March 31, 2020 (in thousands): Total Less than 1 year 1-3 years 3-5 years More than 5 years Vancouver office operating lease $ 171 $ 44 $ 122 $ 5 $ — Seattle office operating lease $ 137 $ 112 $ 25 $ — $ — Total $ 308 $ 156 $ 147 $ 5 $ — Leases We have operating leases for our corporate offices. Operating leases with a term of 12 months or longer are included in ROU assets, other current liabilities, and operating lease liabilities on our consolidated balance sheets. Finance leases are included in property and equipment, other current liabilities, and other long-term liabilities on our consolidated balance sheets. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. As most of our leases do not provide an implicit rate, we use the incremental borrowing rate of comparable companies from a representative peer group selected based on industry and market capitalization. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred. Our lease terms may include options to extend or terminate the lease when it is reasonably certain that we will exercise that option. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. Vancouver lease arrangements We had a lease agreement for office space in Vancouver, British Columbia, which expired in January 2019. Pursuant to the lease agreement, we had the option to terminate the lease early without penalty at any time after January 1, 2017 so long as we provide three months prior written notice to the landlord. This lease was not renewed. This lease was classified as an operating lease. On November 19, 2018, we entered into a lease agreement, or the Vancouver Lease, for new office space in Vancouver, British Columbia, which commenced on February 1, 2019. Pursuant to the terms of the lease agreement, we leased approximately 2,367 square feet located at Suite 1030, The Grosvenor Building, 1040 West Georgia Street, Vancouver, B.C. The initial term of the Vancouver Lease will expire on January 31, 2023, with an option to extend the term for one further four-year period, at a base rent as agreed upon between the parties with a minimum value equal to the base rent payable in the last year of the initial term. The monthly base rent for the premises was approximately $5,200 commencing on February 1, 2019, and on February 1, 2021, will increase up to approximately $5,400. The landlord provided us with a construction allowance of approximately $14,200. In addition, we paid a security deposit of approximately $18,600 upon entering into the lease agreement. The security deposit was reduced by the first month’s rent and operating expenses upon commencement of the Vancouver Lease. The Vancouver Lease was classified as an operating lease. Future minimum lease payments under the Vancouver lease are as follows (in thousands): 2020 44 2021 61 2022 61 2023 5 Total $ 171 Seattle lease arrangement On December 11, 2017, we entered into a lease, or the Seattle Lease, with 520 Pike Street, Inc., or Pike, pursuant to which we leased approximately 3,187 square feet located at Suite 2250 at 520 Pike Tower, Seattle, Washington, 98101, which commenced on March 1, 2018. The initial term of the Seattle Lease will expire at the end of the month on the third anniversary of the Seattle Lease. Our monthly base rent for the premises started at approximately $11,685 which commenced on March 1, 2018 and will increase on an annual basis up to approximately $12,397. In addition, we paid a security deposit to Pike in the amount of $37,192, subject to periodic reductions in the amount of $12,397 after each of the first and second anniversaries of the Seattle Lease, which Pike may retain for base rent or other damages, in the event of our default under the Seattle Lease. We may not assign or sublet all or any portion of the premises without the consent of Pike, and Pike shall be entitled to 50% of any profit which we may receive above and beyond the rental price of the Seattle Lease. Upon receipt of notice of our intent to assign or sublease any portion of the leased premises, Pike may terminate that portion of the premises within 30 days, and provided, that if such portion constitutes 50% or more of the total square footage of the premises, Pike may terminate the Seattle Lease in its entirety. The Seattle Lease was classified as an operating lease. The future minimum annual lease payments under the Seattle Lease are as follows (in thousands): 2020 112 2021 25 Total $ 137 Consolidated lease and operating expense relating to the Vancouver, British Columbia, and Seattle, Washington offices for the three months ended March 31, 2020 was $0.1 million. Consolidated rent expense for the three months ended March 31, 2019 was $0.1 million. Other information related to leases was as follows: Three Months Ended March 31, 2020 2019 Supplemental Cash Flows Information Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from operating leases $ 44 $ 50 Right-of-use assets obtained in exchange for lease obligations: Operating leases — 455 Weighted Average Remaining Lease Term Operating leases 1.99 years 2.80 years Weighted Average Discount Rate Operating leases 9.90 % 9.90 % Guarantees and Indemnifications We indemnify our officers, directors and certain consultants for certain events or occurrences, subject to certain limits, while the officer or director is or was serving at its request in such capacity. The term of the indemnification period is equal to the officer’s or director’s lifetime. The maximum amount of potential future indemnification is unlimited; however, we have obtained director and officer insurance that limits our exposure and may enable us to recover a portion of any future amounts paid. We believe that the fair value of these indemnification obligations is minimal. Accordingly, we have not recognized any liabilities relating to these obligations as of March 31, 2020. We have certain agreements with certain organizations with which we do business that contain indemnification provisions pursuant to which we typically agree to indemnify the party against certain types of third-party claims. We accrue for known indemnification issues when a loss is probable and can be reasonably estimated. There were no accruals for or expenses related to indemnification issues for any period presented. |
Subsequent Events
Subsequent Events | 3 Months Ended |
Mar. 31, 2020 | |
Subsequent Events [Abstract] | |
Subsequent Events | 8. SUBSEQUENT EVENTS On April 27, 2020 and April 28, 2020, we entered into definitive agreements for the private placement of up to 5,615,653 units at a purchase price of $0.33 per unit, with each unit consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock. The warrants issued pursuant to definitive agreements executed on April 27, 2020 are exercisable at a price per share of Common Stock of $0.362, subject to adjustment, and the warrants issued pursuant to definitive agreements executed on April 28, 2020 are exercisable at a price per share of Common Stock of $0.366, subject to adjustment. The warrants are exercisable beginning on October 27, 2020 and will expire on April 27, 2025. In connection with the private placement, we issued a warrant to the placement agent to purchase up to 505,409 shares of common stock, upon substantially similar terms as the warrants issued to investors, and with an initial per share exercise price of $0.3795. The private placement raised total gross proceeds of approximately $1.9 million, and after deducting approximately $0.3 million in placement agent fees and offering expenses, we received net proceeds of approximately $1.6 million. The placement agent fees and offering expenses have been charged against the gross proceeds. |
Intangibles (Tables)
Intangibles (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Goodwill And Intangible Assets Disclosure [Abstract] | |
Components of Intangible Assets | The components of intangible assets were as follows: March 31, 2020 December 31, 2019 Gross Carrying Accumulated Net Carrying Gross Carrying Accumulated Net Carrying Value Amortization Value Value Amortization Value License Agreements $ 3,117 $ (1,086 ) $ 2,031 $ 3,117 $ (1,030 ) $ 2,087 |
Estimated Future Amortization Expense Related to Intangible Assets | The following table outlines the estimated future amortization expense related to intangible assets held as of March 31, 2020 Year Ending December 31, 2020 $ 167 2021 223 2022 223 2023 223 Thereafter 1,195 Total $ 2,031 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Fair Value Disclosures [Abstract] | |
Summary of Assets Measured at Fair Value on Recurring Basis | The following table presents information about our assets that are measured at fair value on a recurring basis, and indicates the fair value hierarchy of the valuation techniques we utilized to determine such fair value (in thousands): March 31, 2020 Level 1 Level 2 Level 3 Total Assets Cash $ 550 $ — $ — $ 550 Money market securities (cash equivalents) 11,606 — — 11,606 Restricted cash 50 — — 50 Total assets $ 12,206 $ — $ — $ 12,206 |
Summary of Cash and Cash Equivalents | Cash and cash equivalents consist of the following (in thousands): Gross Gross Unrealized Unrealized Estimated March 31, 2020 Cost Gains Losses Fair Value Cash $ 550 $ — $ — $ 550 Money market securities 11,606 — — 11,606 Total cash and cash equivalents $ 12,156 $ — $ — $ 12,156 Money market securities (restricted cash) 50 — — 50 Total restricted cash $ 50 $ — $ — $ 50 |
Common Stock (Tables)
Common Stock (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Equity [Abstract] | |
Summary of Stock Options Activity | Stock option transactions and the number of stock options outstanding are summarized below: Number of Weighted Optioned Average Common Exercise Shares Price Balance, December 31, 2019 1,010,583 $ 10.05 Granted 1,497,600 0.56 Forfeited (18,757 ) 4.33 Balance, March 31, 2020 2,489,426 $ 4.38 |
Summary of Fair Value of Each Stock Award for Employees and Directors | The fair value of each stock award for employees and directors is estimated on the grant date and for consultants at each reporting period, using the Black-Scholes option-pricing model based on the weighted-average assumptions noted in the following table: Three Months Ended March 31, 2020 2019 Risk-free interest rates 1.51 % 2.56 % Expected dividend yield 0 % 0 % Expected life 6.02 6.02 Expected volatility 104.06 % 93.72 % |
Summary of Share-Based Compensation Expense | The results for the periods set forth below included share-based compensation expense for stock options and restricted stock units in the following expense categories of the consolidated statements of loss (in thousands): Three Months Ended March 31, 2020 2019 Research and development $ 86 $ 90 General and administrative $ 216 200 Total stock-based compensation $ 302 $ 290 |
Summary of Restricted Stock Unit Award Activity | The following table summarizes our restricted stock unit award activity during the three months ended March 31, 2020 Weighted Number Average of Grant Date Shares Fair Value Balance, December 31, 2019 10,008 $ 28.99 Forfeited or expired (660 ) 28.90 Balance, March 31, 2020 9,348 $ 29.00 |
Summary of Outstanding Warrants | The following is a summary of outstanding warrants to purchase common stock at March 31, 2020 Total Outstanding Exercise and price per Exercisable Share Expiration Date (1) Series A-1 Warrants issued in April 2015 financing 2,175 264.0000 October 2020 (2) Warrants issued in September 2017 financing 8,224 34.9600 March 2023 (3) Warrants issued in June 2018 financing 2,282,000 4.0000 June 2023 (4) Warrants issued in October 2018 financing 624,313 3.1445 October 2023 (5) Warrants issued in May 2019 financing 1,200,000 4.5000 May 2025 (6) Warrants issued in December 2019 financing 23,000,000 0.6000 Dec 2024 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Operating Leased Assets [Line Items] | |
Summary of Contractual Obligations | The following table summarizes our contractual obligations as of March 31, 2020 (in thousands): Total Less than 1 year 1-3 years 3-5 years More than 5 years Vancouver office operating lease $ 171 $ 44 $ 122 $ 5 $ — Seattle office operating lease $ 137 $ 112 $ 25 $ — $ — Total $ 308 $ 156 $ 147 $ 5 $ — |
Summary of Other Information Related to Leases | Other information related to leases was as follows: Three Months Ended March 31, 2020 2019 Supplemental Cash Flows Information Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from operating leases $ 44 $ 50 Right-of-use assets obtained in exchange for lease obligations: Operating leases — 455 Weighted Average Remaining Lease Term Operating leases 1.99 years 2.80 years Weighted Average Discount Rate Operating leases 9.90 % 9.90 % |
Vancouver Office Operating Lease [Member] | |
Operating Leased Assets [Line Items] | |
Summary of Future Minimum Annual Lease Payments | Future minimum lease payments under the Vancouver lease are as follows (in thousands): 2020 44 2021 61 2022 61 2023 5 Total $ 171 |
Seattle Office Operating Lease [Member] | |
Operating Leased Assets [Line Items] | |
Summary of Future Minimum Annual Lease Payments | The future minimum annual lease payments under the Seattle Lease are as follows (in thousands): 2020 112 2021 25 Total $ 137 |
Nature of Business, Basis of _2
Nature of Business, Basis of Presentation and Going Concern Uncertainty - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | ||
Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019 | |
Accounting Policies [Abstract] | |||
Accumulated deficit | $ (49,024) | $ (45,704) | |
Net loss | (3,320) | $ (5,904) | |
Cash and cash equivalents | 12,156 | $ 16,664 | |
Working capital | 11,400 | ||
Net cash used in operations | $ 4,461 | $ 4,889 |
Intangibles - Additional Inform
Intangibles - Additional Information (Detail) - USD ($) | May 18, 2015 | Mar. 31, 2020 | Mar. 31, 2019 |
Goodwill And Intangible Assets Disclosure [Abstract] | |||
Intangible assets, Fair Value | $ 3,100,000 | ||
Intangible assets, Useful life | 14 years | ||
License agreement amortization expense | $ 100,000 | $ 100,000 | |
Impairment of intangible assets | $ 0 |
Intangibles - Components of Int
Intangibles - Components of Intangible Assets (Detail) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Finite Lived Intangible Assets [Line Items] | ||
Intangible assets, Net Carrying Value | $ 2,031 | $ 2,087 |
License Agreements [Member] | ||
Finite Lived Intangible Assets [Line Items] | ||
Intangible assets, Gross Carrying Value | 3,117 | 3,117 |
Intangible assets, Accumulated Amortization | (1,086) | (1,030) |
Intangible assets, Net Carrying Value | $ 2,031 | $ 2,087 |
Intangibles - Estimated Future
Intangibles - Estimated Future Amortization Expense Related to Intangible Assets (Detail) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract] | ||
2020 | $ 167 | |
2021 | 223 | |
2022 | 223 | |
2023 | 223 | |
Thereafter | 1,195 | |
Intangible assets, Net Carrying Value | $ 2,031 | $ 2,087 |
License Agreements - Additional
License Agreements - Additional Information (Detail) | Jan. 22, 2018USD ($) | May 14, 2015 | Jul. 31, 2016USD ($) | Mar. 31, 2020USD ($)g |
Sopharma [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
License agreement expiry date | May 26, 2029 | |||
University of Bristol [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Maximum amount payable under license agreement, tied to milestones | $ 3,200,000 | |||
Payments under license agreement | $ 125,000 | |||
License agreement expiry | 2036-07 | |||
Volume of cytisine provided as an initial contribution | g | 100 | |||
University of Bristol [Member] | Amendment to the University of Bristol License Agreement [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Maximum amount payable under license agreement, tied to milestones | $ 1,700,000 | |||
Payments under license agreement | $ 37,500 | |||
University of Bristol [Member] | Minimum [Member] | License Agreement [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Patent expiry date | Feb. 5, 2036 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Detail) | 3 Months Ended |
Mar. 31, 2020 | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Maximum maturity period of cash and cash equivalents | 90 days |
Maximum [Member] | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Maturity period of securities | 1 year |
Fair Value Measurements - Summa
Fair Value Measurements - Summary of Assets Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring [Member] $ in Thousands | Mar. 31, 2020USD ($) |
Assets | |
Total assets | $ 12,206 |
Cash [Member] | |
Assets | |
Total assets | 550 |
Money market securities (cash equivalents) [Member] | |
Assets | |
Total assets | 11,606 |
Restricted cash [Member] | |
Assets | |
Total assets | 50 |
Level 1 [Member] | |
Assets | |
Total assets | 12,206 |
Level 1 [Member] | Cash [Member] | |
Assets | |
Total assets | 550 |
Level 1 [Member] | Money market securities (cash equivalents) [Member] | |
Assets | |
Total assets | 11,606 |
Level 1 [Member] | Restricted cash [Member] | |
Assets | |
Total assets | $ 50 |
Fair Value Measurements - Sum_2
Fair Value Measurements - Summary of Cash and Cash Equivalents (Detail) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items] | ||
Cash, amortized cost and estimated fair value | $ 550 | |
Cash and cash equivalents, amortized cost and estimated fair value | 12,156 | $ 16,664 |
Restricted cash, amortized cost and estimated fair value | 50 | |
Money market securities [Member] | ||
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items] | ||
Cash equivalents, amortized cost and estimated fair value | 11,606 | |
Restricted cash, amortized cost and estimated fair value | $ 50 |
Common Stock - Authorized - Add
Common Stock - Authorized - Additional Information (Detail) - $ / shares | Mar. 31, 2020 | Dec. 31, 2019 |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | ||
Common stock, shares authorized | 150,000,000 | 150,000,000 |
Common stock, par value | $ 0.001 | $ 0.001 |
Preferred stock, shares authorized | 5,000,000 | |
Preferred stock, par value | $ 0.001 |
Common Stock - Issued and Outst
Common Stock - Issued and Outstanding Shares - Additional Information (Detail) - USD ($) | Mar. 12, 2020 | Dec. 17, 2019 | Jun. 07, 2019 | May 22, 2018 | Sep. 14, 2017 | Mar. 31, 2020 | Mar. 31, 2019 | Mar. 31, 2020 | Dec. 31, 2019 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock, par value | $ 0.001 | $ 0.001 | $ 0.001 | ||||||
Common stock, shares issued | 31,352,764 | 31,352,764 | 29,485,178 | ||||||
Preferred stock, par value | $ 0.001 | $ 0.001 | |||||||
Stock option exercises, Shares | 0 | 0 | |||||||
Restricted stock unit settlements | 0 | 133 | |||||||
Common Stock [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Restricted stock unit settlements | 83 | ||||||||
December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Exercise price per unit of warrant | $ 0.60 | ||||||||
Warrant exercisable period | 5 years | ||||||||
Cancellation of warrant description | Additionally, subject to certain exceptions, if, after December 17, 2019, (i) the volume weighted average price of the common stock for each of 30 consecutive trading days, or the 2019 Measurement Period, which 2019 Measurement Period commences on the closing date, exceeds 300% of the exercise price (subject to adjustments for stock splits, recapitalizations, stock dividends and similar transactions), (ii) the average daily trading volume for such 2019 Measurement Period exceeds $500,000 per trading day and (iii) certain other equity conditions are met, and subject to a beneficial ownership limitation, then the Company may call for cancellation of all or any portion of the warrants then outstanding. | ||||||||
Number of required consecutive days weighted average trading price for cancelation or recall of warrants | 30 days | ||||||||
Minimum required trading price percentage over exercise price for cancelation or recall of warrants | 300.00% | ||||||||
Minimum required trading volume value per day for cancelation or recall of warrants | $ 500,000 | ||||||||
Gross proceeds from sale of warrants and units | $ 13,800,000 | ||||||||
Warrant and units offering cost including underwriting discounts and commissions | 1,500,000 | ||||||||
Net proceeds from issuance of warrants and units | $ 12,300,000 | ||||||||
Series A Convertible Preferred Stock [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Preferred stock, par value | $ 0.001 | $ 0.001 | $ 0.001 | ||||||
Preferred stock, shares outstanding | 0 | 0 | 0 | ||||||
Series B Convertible Preferred Stock [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Preferred stock, par value | $ 0.001 | $ 0.001 | $ 0.001 | ||||||
Preferred stock, shares outstanding | 0 | 0 | 1,121 | ||||||
Series B Convertible Preferred Stock [Member] | December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Preferred stock, shares converted | 6,256 | ||||||||
Preferred stock, shares outstanding | 0 | 0 | |||||||
Series B Convertible Preferred Stock [Member] | December 2019 Public Offering [Member] | Common Stock [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Convertible preferred stock, shares issued upon conversion | 10,422,496 | ||||||||
Maximum [Member] | December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Exercise price per unit of warrant | $ 0.06 | ||||||||
Class A Units [Member] | December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Issuance of new units in a public offering | 9,577,504 | ||||||||
Public offering, price per unit | $ 0.60 | ||||||||
Description of stock units issued | Each Class A Unit consisted of one share of our common stock and a warrant to purchase one share of common stock. | ||||||||
Class B Units [Member] | December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Issuance of new units in a public offering | 6,256 | ||||||||
Public offering, price per unit | $ 999.60 | ||||||||
Description of stock units issued | Each Class B Unit consisted of one share of Series B Convertible Preferred Stock, par value $0.001 per share, convertible at any time at the holder’s option into 1,666 shares of common stock, and warrants to purchase 1,666 shares of common stock. | ||||||||
Number of common shares issuable for each share of convertible preferred stock | 1,666 | ||||||||
Number of common shares issuable conversion of warrants | 1,666 | ||||||||
Class B Units [Member] | Series A Convertible Preferred Stock [Member] | December 2019 Public Offering [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Preferred stock, par value | $ 0.001 | ||||||||
LPC [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock value right to sell, maximum | $ 11,000,000 | ||||||||
Common stock, par value | $ 0.001 | ||||||||
Minimum percentage of common stock shares outstanding authorized to sell | 20.00% | ||||||||
Initial purchase of common stock | 32,895 | ||||||||
Common stock, shares issued | 12,352 | ||||||||
Proceeds from issuance of common stock | $ 0 | ||||||||
Common stock, shares issued | 0 | 557,378 | |||||||
Gross proceeds | $ 4,400,000 | ||||||||
Offering expenses | $ 500,000 | ||||||||
LPC [Member] | Minimum [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock, purchase price | $ 20 | ||||||||
LPC [Member] | Purchase Agreement [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock, purchase price | $ 1 | ||||||||
Additional common stock value right to sell, maximum | $ 10,000,000 | ||||||||
Additional purchase of common stock, maximum | 8,000 | ||||||||
Offering expenses | $ 13,000 | ||||||||
Agreement term | 30 months | ||||||||
Agreement extended term | 54 months | ||||||||
Additional purchase of common stock | 150,000 | 80,000 | |||||||
Payments related to expense reimbursement | $ 100,000 | ||||||||
LPC [Member] | Units [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Initial purchase of common stock | 32,895 | ||||||||
Common stock, purchase price | $ 30.40 | ||||||||
Purchase agreement, description | Unit consisting of (a) one share of our Common Stock and (b) one warrant to purchase one-quarter of a share of Common Stock at an exercise price of $34.96 per share, or Warrant. Each Warrant is exercisable six months following the issuance date until the date that is five years and six months after the issuance date and is subject to customary adjustments. | ||||||||
Exercise price per unit of warrant | $ 34.96 | ||||||||
Initial purchase of units consisting of common stock and warrants issued | $ 1,000,000 | ||||||||
LPC [Member] | Other Units [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Number of warrants issued | 0 | ||||||||
H.C. Wainwright [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock, par value | $ 0.001 | ||||||||
Percentage of commission on gross proceeds from sale of common stock | 3.00% | ||||||||
Common stock available for sale under offering | $ 6,000,000 | ||||||||
H.C. Wainwright [Member] | Maximum [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Common stock value right to sell, maximum | $ 6,000,000 | ||||||||
Ladenburg Thalmann & Co. Inc [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Period granted for underwriting option | 45 days | ||||||||
Ladenburg Thalmann & Co. Inc [Member] | 2019 Overallotment Option [Member] | |||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||||||||
Additional purchase of common stock and warrants, maximum | 3,000,000 | ||||||||
Overallotment option exercise date | Dec. 17, 2019 |
Common Stock - Stock Options -
Common Stock - Stock Options - Additional Information (Detail) - USD ($) $ in Millions | Mar. 31, 2019 | Mar. 31, 2020 | Dec. 31, 2019 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for options currently outstanding | 2,489,426 | 1,010,583 | |
Unrecognized compensation expense related to stock options granted | $ 2.2 | ||
Anti-dilutive securities excluded from earning per share computation | 5,038,584 | 29,615,486 | |
Warrant [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Anti-dilutive securities excluded from earning per share computation | 27,116,712 | ||
Stock Options [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Anti-dilutive securities excluded from earning per share computation | 2,489,426 | ||
Restricted Stock Unit [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Anti-dilutive securities excluded from earning per share computation | 9,348 | ||
Stock Options [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Weighted-average period, restricted stock awards | 2 years 6 months | ||
Stock Options [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 4 years | ||
Stock Options [Member] | Minimum [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award expiration period | 7 years | ||
Stock Options [Member] | Minimum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 1 year | ||
Stock Options [Member] | Maximum [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award expiration period | 10 years | ||
Stock Options [Member] | Maximum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
Restricted Stock Unit [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 4 years | ||
Common shares reserved for awards currently outstanding | 9,348 | 10,008 | |
Weighted-average period, restricted stock awards | 1 year 4 months 2 days | ||
2018 Equity Incentive Plan [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for issuance under incentive plan | 594,209 | ||
Award expiration period | 10 years | ||
2018 Equity Incentive Plan [Member] | Minimum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2018 Equity Incentive Plan [Member] | Minimum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 1 year | ||
2018 Equity Incentive Plan [Member] | Maximum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 4 years | ||
2018 Equity Incentive Plan [Member] | Maximum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2018 Equity Incentive Plan [Member] | Stock Options [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for issuance under incentive plan | 2,810,314 | ||
Common shares reserved for options currently outstanding | 2,216,105 | ||
2017 Equity Incentive Plan [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award expiration period | 10 years | ||
2017 Equity Incentive Plan [Member] | Minimum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2017 Equity Incentive Plan [Member] | Minimum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 1 year | ||
2017 Equity Incentive Plan [Member] | Maximum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 4 years | ||
2017 Equity Incentive Plan [Member] | Maximum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2017 Equity Incentive Plan [Member] | Stock Options [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for issuance under incentive plan | 267,398 | ||
2010 Performance Incentive Plan [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award expiration period | 10 years | ||
2010 Performance Incentive Plan [Member] | Minimum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2010 Performance Incentive Plan [Member] | Minimum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 1 year | ||
2010 Performance Incentive Plan [Member] | Maximum [Member] | Employees and Consultants [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 4 years | ||
2010 Performance Incentive Plan [Member] | Maximum [Member] | Board of Directors [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Award vesting period | 3 years | ||
2010 Performance Incentive Plan [Member] | Stock Options [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for issuance under incentive plan | 15,271 | ||
Common shares reserved for options currently outstanding | 5,923 | ||
2010 Performance Incentive Plan [Member] | Restricted Stock Unit [Member] | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Common shares reserved for awards currently outstanding | 9,348 |
Common Stock - Summary of Stock
Common Stock - Summary of Stock Options Activity (Detail) | 3 Months Ended |
Mar. 31, 2020$ / sharesshares | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Number of Optioned Common Shares, Beginning Balance | shares | 1,010,583 |
Number of Optioned Common Shares, Granted | shares | 1,497,600 |
Number of Optioned Common Shares, Forfeited | shares | (18,757) |
Number of Optioned Common Shares, Ending Balance | shares | 2,489,426 |
Weighted Average Exercise Price, Beginning Balance | $ / shares | $ 10.05 |
Weighted Average Exercise Price, Granted | $ / shares | 0.56 |
Weighted Average Exercise Price, Forfeited | $ / shares | 4.33 |
Weighted Average Exercise Price, Ending Balance | $ / shares | $ 4.38 |
Common Stock - Summary of Fair
Common Stock - Summary of Fair Value of Each Stock Award for Employees and Directors (Detail) | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | ||
Risk-free interest rates | 1.51% | 2.56% |
Expected dividend yield | 0.00% | 0.00% |
Expected life | 6 years 7 days | 6 years 7 days |
Expected volatility | 104.06% | 93.72% |
Common Stock - Summary of Share
Common Stock - Summary of Share-Based Compensation Expense for Stock Options and Restricted Stock (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation | $ 302 | $ 290 |
Research and development [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation | 86 | 90 |
General and administrative [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation | $ 216 | $ 200 |
Common Stock - Restricted Stock
Common Stock - Restricted Stock Unit Awards - Additional Information (Detail) - Restricted Stock Unit [Member] - USD ($) | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Award vesting period | 4 years | |
Stock based compensation expense | $ 30,000 | $ 37,000 |
Total unrecognized compensation expense related to the Company's restricted stock unit awards | $ 200,000 | |
Weighted-average period, restricted stock awards | 1 year 4 months 2 days |
Common Stock - Summary of Restr
Common Stock - Summary of Restricted Stock Unit Award Activity (Detail) - Restricted Stock Unit [Member] | 3 Months Ended |
Mar. 31, 2020$ / sharesshares | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |
Number of Shares, Beginning Balance | shares | 10,008 |
Number of Shares, Forfeited or expired | shares | (660) |
Number of Shares, Ending Balance | shares | 9,348 |
Weighted-Average Grant Date Fair Value, Beginning Balance | $ / shares | $ 28.99 |
Weighted-Average Grant Date Fair Value, Forfeited or expired | $ / shares | 28.90 |
Weighted-Average Grant Date Fair Value, Ending Balance | $ / shares | $ 29 |
Common Stock - Common Stock War
Common Stock - Common Stock Warrants - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions | May 30, 2019 | Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019 |
Class of Warrant or Right [Line Items] | ||||
Common stock, par value | $ 0.001 | $ 0.001 | ||
Expected volatility | 104.06% | 93.72% | ||
Risk-free interest rate | 1.51% | 2.56% | ||
Expected term | 6 years 7 days | 6 years 7 days | ||
Number of warrants exercised | 0 | 0 | ||
New Warrant [Member] | ||||
Class of Warrant or Right [Line Items] | ||||
Fair value of warrants recognized into accumulated deficit | $ (3.9) | |||
Stock price | $ 4.23 | |||
Expected volatility | 97.16% | |||
Risk-free interest rate | 2.06% | |||
Expected term | 6 years | |||
Armistice [Member] | ||||
Class of Warrant or Right [Line Items] | ||||
Proceeds from aggregate warrant exercise | $ 4.2 | |||
Armistice [Member] | October 2018 Financing [Member] | ||||
Class of Warrant or Right [Line Items] | ||||
Warrants to purchase common stock | 270,313 | |||
Common stock, par value | $ 0.001 | |||
Exercise price per unit of warrant | $ 3.1445 | |||
Armistice [Member] | June 2018 Financing [Member] | ||||
Class of Warrant or Right [Line Items] | ||||
Warrants to purchase common stock | 837,500 | |||
Exercise price per unit of warrant | $ 4 | |||
Armistice [Member] | New Warrant [Member] | ||||
Class of Warrant or Right [Line Items] | ||||
Warrants to purchase common stock | 1,200,000 | |||
Exercise price per unit of warrant | $ 4.50 | |||
Warrants, exercise period | 6 years |
Common Stock - Summary of Outst
Common Stock - Summary of Outstanding Warrants (Detail) | 3 Months Ended |
Mar. 31, 2020$ / sharesshares | |
Series A-1 Warrants [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 2,175 |
Exercise price per Share | $ / shares | $ 264 |
Expiration Date | 2020-10 |
Warrants Issued In September 2017 [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 8,224 |
Exercise price per Share | $ / shares | $ 34.9600 |
Expiration Date | 2023-03 |
Warrants Issued In June 2018 [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 2,282,000 |
Exercise price per Share | $ / shares | $ 4 |
Expiration Date | 2023-06 |
Warrants Issued in October 2018 [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 624,313 |
Exercise price per Share | $ / shares | $ 3.1445 |
Expiration Date | 2023-10 |
Warrants Issued in May 2019 [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 1,200,000 |
Exercise price per Share | $ / shares | $ 4.5000 |
Expiration Date | 2025-05 |
Warrants Issued in December 2019 [Member] | |
Class of Warrant or Right [Line Items] | |
Total Outstanding and Exercisable | shares | 23,000,000 |
Exercise price per Share | $ / shares | $ 0.6000 |
Expiration Date | 2024-12 |
Commitments and Contingencies -
Commitments and Contingencies - Summary of Contractual Obligations (Detail) $ in Thousands | Mar. 31, 2020USD ($) |
Contractual Obligation Fiscal Year Maturity Schedule [Line Items] | |
Total | $ 308 |
Less than 1 year | 156 |
1-3 years | 147 |
3-5 years | 5 |
Vancouver Office Operating Lease [Member] | |
Contractual Obligation Fiscal Year Maturity Schedule [Line Items] | |
Total | 171 |
Less than 1 year | 44 |
1-3 years | 122 |
3-5 years | 5 |
Seattle Office Operating Lease [Member] | |
Contractual Obligation Fiscal Year Maturity Schedule [Line Items] | |
Total | 137 |
Less than 1 year | 112 |
1-3 years | $ 25 |
Commitments and Contingencies_2
Commitments and Contingencies - Additional Information (Detail) | Nov. 19, 2018USD ($)ft² | Dec. 11, 2017ft² | Mar. 31, 2020USD ($) | Mar. 31, 2019USD ($) | Mar. 01, 2018USD ($) |
Other Commitments [Line Items] | |||||
Indemnification obligations | $ 0 | ||||
Expenses related to indemnification issues | $ 0 | ||||
Vancouver Office Operating Lease [Member] | |||||
Other Commitments [Line Items] | |||||
Expiration of operating lease agreement | 2019-01 | ||||
Consolidated lease rent and facilities expense | $ 100,000 | $ 100,000 | |||
Vancouver Office Operating Lease [Member] | Vancouver, British Columbia [Member] | |||||
Other Commitments [Line Items] | |||||
Lease agreement commencement date | Feb. 1, 2019 | ||||
Area of office space leased | ft² | 2,367 | ||||
Initial term of lease expiration date | Jan. 31, 2023 | ||||
Operating lease, term of contract | 4 years | ||||
Operating lease, option to extend, description | The initial term of the Vancouver Lease will expire on January 31, 2023, with an option to extend the term for one further four-year period | ||||
Lessee, Operating Lease, Existence of Option to Extend [true false] | true | ||||
Operating lease, initial monthly base rent expenses | $ 5,200,000 | ||||
Operating lease, revised monthly base rent expenses | 5,400,000 | ||||
Construction allowance | 14,200,000 | ||||
Security deposit | $ 18,600,000 | ||||
Seattle Office Operating Lease [Member] | |||||
Other Commitments [Line Items] | |||||
Consolidated lease rent and facilities expense | $ 100,000 | $ 100,000 | |||
Seattle Office Operating Lease [Member] | Pike [Member] | |||||
Other Commitments [Line Items] | |||||
Area of office space leased | ft² | 3,187 | ||||
Lease agreement | On December 11, 2017, we entered into a lease, or the Seattle Lease, with 520 Pike Street, Inc., or Pike, pursuant to which we leased approximately 3,187 square feet located at Suite 2250 at 520 Pike Tower, Seattle, Washington, 98101, which commenced on March 1, 2018. The initial term of the Seattle Lease will expire at the end of the month on the third anniversary of the Seattle Lease. | ||||
Monthly base rent | $ 11,685,000 | ||||
Monthly base rent, maximum annual increase | 12,397,000 | ||||
Lease, security deposit, annual payment | 37,192,000 | ||||
Lease, security deposit payment, annual decrease | $ 12,397,000 | ||||
Percentage of profit attributable to lessor | 50.00% | ||||
Percentage of property if subleased could result in lease termination | 50.00% |
Commitments and Contingencies_3
Commitments and Contingencies - Summary of Future Minimum Annual Lease Payments (Detail) $ in Thousands | Mar. 31, 2020USD ($) |
Vancouver Office Operating Lease [Member] | |
Operating Leased Assets [Line Items] | |
2020 | $ 44 |
2021 | 61 |
2022 | 61 |
2023 | 5 |
Total | 171 |
Seattle Office Operating Lease [Member] | |
Operating Leased Assets [Line Items] | |
2020 | 112 |
2021 | 25 |
Total | $ 137 |
Commitments and Contingencies_4
Commitments and Contingencies - Summary of Other Information Related to Leases (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Cash paid for amounts included in the measurement of lease liabilities: | ||
Operating cash flows from operating leases | $ 44 | $ 50 |
Right-of-use assets obtained in exchange for lease obligations: | ||
Operating leases | $ 455 | |
Weighted Average Remaining Lease Term Operating leases | 1 year 11 months 26 days | |
Weighted Average Discount Rate Operating leases | 9.90% | 9.90% |
Subsequent Events - Additional
Subsequent Events - Additional Information (Detail) - Subsequent Event [Member] - Private Placement [Member] - USD ($) $ / shares in Units, $ in Millions | Apr. 28, 2020 | Apr. 27, 2020 |
Subsequent Event [Line Items] | ||
Common stock, shares issued | 5,615,653 | |
Common stock, price per share | $ 0.33 | |
Warrants to purchase shares of common stock | 0.75 | |
Description of stock units issued | each unit consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock | |
Exercise price per unit of warrant | $ 0.366 | $ 0.362 |
Warrant exercisable date | Oct. 27, 2020 | |
Warrant expiration date | Apr. 27, 2025 | |
Gross proceeds from issuance of common stock | $ 1.9 | |
Placement agent fees and offering expenses | 0.3 | |
Proceeds from issuance of common stock | $ 1.6 | |
Placement Agent [Member] | ||
Subsequent Event [Line Items] | ||
Exercise price per unit of warrant | $ 0.3795 | |
Maximum number of common shares issuable per warrant upon conversion | 505,409 |