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                          March 9, 2022

       Brian Mitts
       Chief Financial Officer
       NexPoint Real Estate Finance, Inc.
       300 Crescent Court, Suite 700
       Dallas, Texas 75201

                                                        Re: NexPoint Real
Estate Finance, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed March 4, 2022
                                                            File No. 333-263300

       Dear Mr. Mitts:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Victor
Rivera Melendez at 202-551-4182 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Real Estate & Construction
       cc:                                              Justin S. Reinus, Esq.