United States securities and exchange commission logo March 9, 2022 Brian Mitts Chief Financial Officer NexPoint Real Estate Finance, Inc. 300 Crescent Court, Suite 700 Dallas, Texas 75201 Re: NexPoint Real Estate Finance, Inc. Registration Statement on Form S-3 Filed March 4, 2022 File No. 333-263300 Dear Mr. Mitts: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Victor Rivera Melendez at 202-551-4182 with any questions. Sincerely, Division of Corporation Finance Office of Real Estate & Construction cc: Justin S. Reinus, Esq.