Registration No. 333-27751

        As filed with the Securities and Exchange Commission on May 21, 1997



                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549


                         POST EFFECTIVE AMENDMENT NO. 1
                                  TO FORM S-8

                            
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933



                             BIOPHARMACEUTICS, INC.
             (Exact name of registrant as specified in its charter)


         Delaware                                           13-3186327
         (State or other                                (I.R.S. Employer
         jurisdiction of                              Identification Number)
         incorporation or
         organization)


                                990 Station Road
                               Bellport, NY 11713
                                 (516) 286-5900

               (Address, including zip code, and telephone number,
        including are code, or registrant's principal executive offices)


                            BIOPHARMACEUTICS, INC.
             1997 EMPLOYEE AND CONSULTANT STOCK OPTION PLAN
                              (Full title of plan)

                                   Edward Fine
                                    President
                             Biopharmaceutics, Inc.
                                990 Station Road
                               Bellport, NY 11713

              (Name and address, including zip code, and telephone
               number, including area code, of agent for service)

                                   Copies to:

                              Alfred V. Greco, P.C.
                          666 Fifth Avenue (14th Floor)
                               New York, NY 10103
                                 (212) 246-6550












                         CALCULATION OF REGISTRATION FEE

======================== ====================== ====================== ====================== ======================
Title of Each Class of   Amount to be           Proposed Maximum       Proposed Maximum       Amount of
Securities to be         Registered(1)          Offering Price Per     Aggregate Offering     Registration Fee(3)
Registered                                      Share(1)               Price(1)
======================== ====================== ====================== ====================== ======================
                                                                                              
Common Stock, par
value $.001 per
share(2)
                         6,500,000              $0.60                  $3,900,000             $1,344.83
======================== ====================== ====================== ====================== ======================

<FN>








(1)      Estimated solely for the purpose of  calculating  the registration fee.
(2)      The shares  registered  pursuant  to this  Registration  Statement  are
         available for grant as of the date of this Registration Statement under
         the  Company's  1997  Employee  and  Consultants  Stock Option Plan and
         available for issuance  pursuant to certain stock option agreements the
         forms of which are attached as exhibits to this Registration Statement.
(3)      Pursuant  to  General  Instruction  E,  the  registration  fee  paid in
         connection  herewith is based on the maximum  aggregate  price at which
         securities  covered by this  registration  statement are Proposed to be
         offered.  This fee was previously paid with original filing.

</FN>






                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the city of New York, New York, on this day of May 29, 1997.

                                      BIOPHARMACEUTICS, INC.



                            By:  /s/ Edward Fine    
                                Edward Fine
                                Principal Executive Officer


         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

Signature                    Capacity in Which Signed             Date




/s/ Edward Fine
Edward Fine                Chairman of the Board,             May 29, 1997
                           Chief Executive Officer and
                           Director (Principal
                           Executive Officer)



/s/ William Kugler
William Kugler            Vice President,                     May 29, 1997
                          Chief Financial Officer
                          (Chief Financial Officer
                          and Principal Accounting
                          Officer)



/s/ Russell Cleveland
Russell Cleveland          Director                           May 29, 1997
                                                                            



/s/ Jonathan Rosen
Jonathan Rosen             Director                           May 29, 1997
                                                                            



/s/ Barry Weissberg
Barry Weissberg            Director                           May 29, 1997
                                                                           







POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE  PRESENTS,  that each person whose  signature
appears below  constitutes  and appoints  Edward Fine and William  Kugler as his
true and lawful  attorney-in-fact and agent, with full power of substitution and
resubstitution,  for  him  and in his  name,  place  and  stead,  in any and all
capacities, to sign any and all amendments (including post-effective amendments)
and supplements to this  Registration  Statement,  and to file the same with the
Securities and Exchange Commission,  granting until said  attorneys-in-fact  and
agent,  and each of them,  full power and  authority  to do and perform each and
every act and thing requisite and necessary to be done in connection  therewith,
as fully to all intents and  purposes as he might or could do in person,  hereby
ratifying and confirming all that said  attorneys-in-fact  and agents, or any of
them or their substitute or substitutes,  may lawfully do or cause to be done by
virtue hereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

Signature                  Capacity in Which Signed                Date



/s/ Edward Fine
Edward Fine                Chairman of the Board,             May 29, 1997
                           Chief Executive Officer and
                           Director (Principal
                           Executive Officer)



/s/ William Kugler
William Kugler             Vice President,                    May 29, 1997
                           Chief Financial Officer
                           (Chief Financial
                           Officer and Principal
                           Accounting Officer)



/s/ Russell Cleveland
Russell Cleveland          Director                           May 29, 1997
                                                                            



/s/ Jonathan Rosen
Jonathan Rosen             Director                           May 29, 1997
                                                                           



/s/ Barry Weiseberg
Barry Weissberg            Director                           May 29, 1997