April 28, 2010

Ms. Laura E. Hatch

United States Securities and Exchange Commission
Division of Investment Management
100 F Street, N.E.

Washington, DC 20549

Re:      GAMCO Global Series Funds, Inc. (the "Company")
         Post-Effective Amendment No. 22 to the Registration Statement
         on Form N-1A (33-66262)

Dear. Ms. Hatch:

         This letter  responds to your  comments  communicated  by  telephone on
April 7 and April 22 2010, with respect to the  Post-Effective  Amendment No. 22
to the Registration Statement on Form N-1A (the "Registration Statement") of the
Company that was filed with the Securities and Exchange  Commission  (the "SEC")
on February 26, 2010 (accession  number  0000950123-10-017797),  with respect to
the GAMCO Global  Telecommunications  Fund,  the GAMCO Global  Growth Fund,  the
GAMCO Global Opportunity Fund and the GAMCO Global  Convertible  Securities Fund
(each, a "Fund" and together, the "Funds"), the four series of the Company.

         In addition,  in connection with this filing, the Company hereby states
the following:

         1.       The Company  acknowledges that in connection with the comments
                  made by the Staff of the SEC,  the Staff has not passed on the
                  accuracy or adequacy of the  disclosure  made herein,  and the
                  Company  and its  management  are solely  responsible  for the
                  content of such disclosure;

         2.       The  Company  acknowledges  that  the  Staff's  comments,  and
                  changes in disclosure in response to the Staff's comments,  do
                  not  foreclose  the SEC or  other  regulatory  body  from  the
                  opportunity  to seek  enforcement  or take other  action  with
                  respect to the disclosure made herein; and

         3.       The Company represents that neither it nor its management will
                  assert  the  Staff's  comments  or changes  in  disclosure  in
                  response to the Staff's comments as a defense in any action or
                  proceeding by the SEC or any person.

                  The Company's  responses to your comments are reflected below.
         Comments that applied to both the Class AAA Shares  prospectus  and the
         Class  ABCI  Shares  prospectus  have only  been  addressed  once.  The
         substance  of  your  comments  has  been  restated  for  your  ease  of
         reference.


         COMMENT  #1-COVER  PAGE:  You requested  that the Company pare down the
         information  in  the  top  left  hand  corner  to  remove   duplicative
         references.

                  RESPONSE   #1:  The  Company   has   deleted   the   following
                  parenthetical   language  that  appears  at  the  end  of  the
                  disclosure in the top left hand corner:  "(Net Asset Value per
                  share may be obtained daily by calling  800-GABELLI after 7:00
                  p.m.)."

         COMMENT  #2-COVER PAGE: You requested that the Company add the required
         legend   disclosure  if  the  Company  intends  to  utilize  a  summary
         prospectus.

                  RESPONSE  #2:  The  Company  will not be  utilizing  a summary
                  prospectus  at this time and therefore the legend has not been
                  added.

         COMMENT    #3-PRINCIPAL    INVESTMENT    STRATEGIES    (GAMCO    GLOBAL
         TELECOMMUNICATIONS  FUND):  You noted that  because of Rule 35d-1 under
         the  Investment  Company  Act of 1940 (the  "1940  Act") and the Fund's
         policy  of   investing   80%  of  its  net  assets  in  stocks  in  the
         telecommunications industry (the " 80% Policy"), the Telecommunications
         Fund should have a concentration policy to the effect that at least 25%
         of its assets will be invested in the telecommunications  industry (the
         "Concentration  Policy") and that such policy  should be a  fundamental
         policy.  Consequently,  you requested that the Telecommunications  Fund
         add  disclosure  to the Company's  Statement of Additional  Information
         ("SAI")  that  the   Telecommunications   Fund  has  a  non-fundamental
         Concentration  Policy.  Additionally,  you  requested  that the Company
         represent  that at the next  meeting of  shareholders,  a  proposal  be
         presented to the  shareholders of the  Telecommunications  Fund seeking
         shareholder  approval  of the  Concentration  Policy  as a  fundamental
         policy of the Telecommunications Fund.

                  RESPONSE  #3:  The  Company  will  set  forth  in  its  SAI  a
                  description of the  Telecommunications  Fund's non-fundamental
                  25%  concentration  policy  regarding  the  telecommunications
                  industry,  but will  also note  that  such  policy  may not be
                  changed  without  shareholder   approval  in  accordance  with
                  Section 13(a)(3) of the 1940 Act. The SAI will also state that
                  at the  next  shareholder  meeting  of the  Company,  it  will
                  present   a   proposal    to   the    shareholders    of   the
                  Telecommunications  Fund seeking  shareholder  approval of the
                  Concentration   Policy   as  a   fundamental   policy  of  the
                  Telecommunications  Fund,  pursuant to an undertaking given by
                  the Company to the SEC.

         COMMENT #4-PRINCIPAL  INVESTMENT STRATEGIES:  (ALL FUNDS): Because each
         Fund has the word  "global" in its fund name,  you  requested  that the
         Company  state  that  each Fund  invests  at least 40% of its total net
         assets in non-U.S.  securities  and that each Fund invest in securities
         of issuers in at least three  countries.


         Additionally, you requested that this disclosure be added in either the
         "Principal Investment Strategies" section or the Item 9 disclosure.

                  RESPONSE  #4:  Based on  conversations  between  the Staff and
                  Company counsel,  the following language has been proposed and
                  agreed upon with respect to the  disclosure in the  prospectus
                  Summary for the Convertible  Securities Fund under  "Principal
                  Investment  Strategies":  "As a global fund,  the  Convertible
                  Securities  Fund invests in securities of issuers,  or related
                  investments    thereof,   in   at   least   three   countries.
                  Additionally, over the course of the next six months, the Fund
                  intends to achieve and  maintain  thereafter  a  portfolio  in
                  which at least  40% of its total net  assets  is  invested  in
                  securities   of  non-U.S.   issuers  or  related   investments
                  thereof."

         COMMENT    #5-PRINCIPAL    INVESTMENT    STRATEGIES    (GAMCO    GLOBAL
         TELECOMMUNICATIONS  FUND):  You noted that the first  paragraph  states
         that  the Fund  invests  primarily  in  small-  and  mid-capitalization
         issuers.  You requested that if the Fund invests a significant  portion
         of its  portfolio  in such  issuers,  the  Fund add  disclosure  to the
         "Principal Risks" section.

                  RESPONSE #5: The GAMCO Global  Telecommunications Fund invests
                  a  significant  portion of its portfolio in small- and mid-cap
                  issuers,  thus the Fund has  added the  following  risk in the
                  "Principal  Risks"  section  under  "Investing  in the  Global
                  Telecommunications Fund involves the following risks:"

                  o SMALL AND  MID-CAPITALIZATION  RISK. Risk is greater for the
                  securities   of  small-   and   mid-capitalization   companies
                  (including  small  unseasoned  companies  that  have  been  in
                  operation  less than three years)  because they  generally are
                  more vulnerable than larger  companies to adverse  business or
                  economic   developments   and  they  may  have  more   limited
                  resources.  The  securities  of small- and  mid-capitalization
                  companies also may trade less frequently and in smaller volume
                  than  larger  companies.  As  a  result,  the  value  of  such
                  securities  may be more volatile than the securities of larger
                  companies,   and  the  Fund  may   experience   difficulty  in
                  purchasing or selling such  securities at the desired time and
                  price.

                  The Funds also added the  following  risk in the  "Information
                  About the Funds' Investment Objectives,  Investment Strategies
                  and  Related  Risks"  section  under  "Investing  in the Funds
                  involves the following risks:"

                  o SMALL AND MID-CAPITALIZATION RISK. GLOBAL TELECOMMUNICATIONS
                  FUND AND GLOBAL  GROWTH  FUND ONLY -- Risk is greater  for the
                  securities   of  small-   and   mid-capitalization   companies
                  (including  small  unseasoned  companies  that  have  been  in
                  operation  less than three years)  because they  generally are
                  more vulnerable than larger  companies to adverse  business


                  or  economic  developments  and  they may  have  more  limited
                  resources.  The  securities  of small- and  mid-capitalization
                  companies also may trade less frequently and in smaller volume
                  than  larger  companies.  As  a  result,  the  value  of  such
                  securities  may be more volatile than the securities of larger
                  companies,   and  the  Fund  may   experience   difficulty  in
                  purchasing or selling such  securities at the desired time and
                  price.

         COMMENT  #6-PERFORMANCE TABLE (GAMCO GLOBAL  TELECOMMUNICATIONS  FUND):
         You  requested  that the Fund delete the  footnote  to the  performance
         table.

                  RESPONSE #6: The Fund has deleted the footnote.

         COMMENT  #7-MANAGEMENT  (GAMCO  GLOBAL  TELECOMMUNICATIONS  FUND):  You
         requested  that the Fund  create a new  paragraph  for the  sub-section
         entitled "The Portfolio Managers."

                  RESPONSE #7: The Fund has made this formatting change.

         COMMENT #8-PRINCIPAL  INVESTMENT STRATEGIES (GAMCO GLOBAL GROWTH FUND):
         You noted that the first paragraph  states that the Fund will invest at
         least 65% of its total assets in common stocks of companies involved in
         the  global   marketplace  and  requested  that  the  Fund  provide  an
         explanation of what "involved in the global marketplace" means.

                  RESPONSE  #8: The GAMCO  Global  Growth Fund has  replaced the
                  first  sentence  of  the  "Principal  Investment   Strategies"
                  section  of  GAMCO  Global  Growth  Fund  with  the  following
                  sentence:

                  "Under normal market  conditions,  the Global Growth Fund will
                  invest at least 65% of its  total  assets in common  stocks of
                  companies  which the Adviser's  portfolio  management team for
                  the  Global  Growth  Fund  believes  are  likely to have rapid
                  growth  in  revenues  and  earnings  and  potential  for above
                  average capital appreciation or are undervalued."

         COMMENT #9-PRINCIPAL  INVESTMENT STRATEGIES (GAMCO GLOBAL GROWTH FUND):
         You noted  that the first  paragraph  states  that the Fund  invests in
         small- and  mid-capitalization  issuers. You requested that if the Fund
         invests a significant  portion of its  portfolio in such  issuers,  the
         Fund add disclosure to the "Principal Risks" section.

                  RESPONSE  #9: The GAMCO  Global  Growth  Fund has  revised the
                  first  sentence of the second  paragraph  under the "Principal
                  Investment Strategies" section to read:

                  "The Global Growth Fund invests  primarily in common stocks of
                  foreign     and      domestic      mid-capitalization      and
                  large-capitalization issuers."


                  The GAMCO  Global  Growth  Fund has added the  following  risk
                  under  "Investing  in the  Global  Growth  Fund  involves  the
                  following risks:":

                  o MID-CAPITALIZATION  RISK. Risk is greater for the securities
                  of  mid-capitalization  companies  because they  generally are
                  more vulnerable than larger  companies to adverse  business or
                  economic   developments   and  they  may  have  more   limited
                  resources. The securities of mid-capitalization companies also
                  may trade less  frequently  and in smaller  volume than larger
                  companies.  As a result,  the value of such  securities may be
                  more volatile than the securities of larger companies, and the
                  Fund may  experience  difficulty in purchasing or selling such
                  securities at the desired time and price.

                  The Funds also added the  following  risk in the  "Information
                  About the Funds' Investment Objectives,  Investment Strategies
                  and  Related  Risks"  section  under  "Investing  in the Funds
                  involves the following risks:"

                  o  MID-CAPITALIZATION  RISK. GLOBAL GROWTH FUND ONLY --Risk is
                  greater for the  securities  of  mid-capitalization  companies
                  because  they  generally  are  more   vulnerable  than  larger
                  companies  to adverse  business or economic  developments  and
                  they  may have  more  limited  resources.  The  securities  of
                  mid-capitalization  companies  also may trade less  frequently
                  and in smaller volume than larger companies.  As a result, the
                  value  of  such  securities  may be  more  volatile  than  the
                  securities of larger  companies,  and the Fund may  experience
                  difficulty  in  purchasing  or selling such  securities at the
                  desired time and price.

         COMMENT #10-PRINCIPAL INVESTMENT STRATEGIES (GAMCO GLOBAL GROWTH FUND):
         You noted  the  second  paragraph  states  that the Fund may  invest in
         emerging  markets and  requested  that the Fund add  disclosure  to the
         "Principal Risks" section if the Fund invests a significant  portion of
         its portfolio in emerging markets.

                  RESPONSE  #10: The GAMCO Global  Growth Fund does not invest a
                  significant portion of its portfolio in emerging markets.

         COMMENT  #11-FEES  AND EXPENSES OF THE FUND (GAMCO  GLOBAL  OPPORTUNITY
         FUND):  You requested that the last sentence in the footnote to the Fee
         Table be moved to the statutory section of the prospectus.

                  RESPONSE #11: This  sentence  already  exists in the statutory
                  section of the prospectus in the section entitled  "Management
                  of the  Funds."  The  Fund has  deleted  the  sentence  in the
                  footnote to the Fee Table.


         COMMENT  #12-PRINCIPAL  INVESTMENT STRATEGIES (GAMCO GLOBAL OPPORTUNITY
         FUND): You noted that the second paragraph states that the Fund invests
         in small-capitalization issuers. You requested that if the Fund invests
         a significant  portion of its  portfolio in such issuers,  the Fund add
         disclosure to the "Principal Risks" section.

                  RESPONSE #12: The GAMCO Global  Opportunity Fund has added the
                  following risk under "Investing in the Global Opportunity Fund
                  involves the following risks:":

                  o  SMALL   CAPITALIZATION   RISK.  Risk  is  greater  for  the
                  securities of small-capitalization  companies (including small
                  unseasoned  companies  that have been in  operation  less than
                  three years) because they generally are more  vulnerable  than
                  larger companies to adverse business or economic  developments
                  and they may have more limited  resources.  The  securities of
                  small-capitalization  companies also may trade less frequently
                  and in smaller volume than larger companies.  As a result, the
                  value  of  such  securities  may be  more  volatile  than  the
                  securities of larger  companies,  and the Fund may  experience
                  difficulty  in  purchasing  or selling such  securities at the
                  desired time and price.

                  The Funds also added the  following  risk in the  "Information
                  About the Funds' Investment Objectives, Investment and Related
                  Risks"  section  under  "Investing  in the Funds  involves the
                  following risks:"

                  o SMALL  CAPITALIZATION  RISK. GLOBAL OPPORTUNITY FUND ONLY --
                  Risk is greater  for the  securities  of  small-capitalization
                  companies (including small unseasoned companies that have been
                  in operation less than three years) because they generally are
                  more vulnerable than larger  companies to adverse  business or
                  economic   developments   and  they  may  have  more   limited
                  resources.  The securities of  small-capitalization  companies
                  also may trade  less  frequently  and in smaller  volume  than
                  larger  companies.  As a result,  the value of such securities
                  may be more volatile than the securities of larger  companies,
                  and the  Fund  may  experience  difficulty  in  purchasing  or
                  selling such securities at the desired time and price.

         COMMENT  #13-FEES  AND EXPENSES OF THE FUND (GAMCO  GLOBAL  CONVERTIBLE
         SECURITIES  FUND): You requested that the last sentence in the footnote
         to the Fee Table be moved to the statutory section of the prospectus.

                  RESPONSE #13: This  sentence  already  exists in the statutory
                  section of the prospectus in the section entitled  "Management
                  of the  Funds."  The  Fund has  deleted  the  sentence  in the
                  footnote to the Fee Table.

         COMMENT  #14-PRINCIPAL  INVESTMENT STRATEGIES (GAMCO GLOBAL CONVERTIBLE
         SECURITIES  FUND): You noted that this section states that the Fund may
         invest


         without limit in securities  that are not considered  investment  grade
         and  requested  that the Fund add  disclosure  to  indicate  that these
         investments are junk bonds.

                  RESPONSE #14: The GAMCO Global  Convertible Fund has added the
                  following risk under "Investing in the Global Convertible Fund
                  involves the following risks:":

                  o LOWER RATED SECURITIES. The Fund may invest up to 25% of its
                  assets in lower credit fixed income  securities that are below
                  investment  grade,  including  up  to  5%  of  its  assets  in
                  securities  of issuers that are in default.  These  securities
                  may involve major risk exposures such as increased sensitivity
                  to interest rate and economic changes,  and the market to sell
                  such  securities  may be limited.  These  securities are often
                  referred to in the financial press as "junk bonds."

                  The Funds also added the  following  risk in the  "Information
                  About the Funds' Investment Objectives,  Investment Strategies
                  and  Related  Risks"  section  under  "Investing  in the Funds
                  involves the following risks:"

                  o LOWER RATED SECURITIES.  GLOBAL CONVERTIBLE  SECURITIES FUND
                  ONLY -- The Fund may  invest up to 25% of its  assets in fixed
                  income securities that are below investment  grade,  including
                  up to 5% of its assets in  securities  of issuers  that are in
                  default.  These  securities  may involve major risk  exposures
                  such as increased  sensitivity  to interest  rate and economic
                  changes,  and  the  market  to  sell  such  securities  may be
                  limited.  These  securities  are  often  referred  to  in  the
                  financial press as "junk bonds."

         COMMENT  #15-PERFORMANCE  TABLE (ALL  FUNDS):  You  requested  that the
         Company  delete the second  sentence of the text after the  performance
         table regarding  "Return After Taxes on Distributions  and Sale of Fund
         Shares" if it is not applicable for a Fund.

                  RESPONSE #15: If this disclosure is not applicable for a Fund,
                  the Company will remove it as appropriate.

         COMMENT #16-STATEMENT OF ADDITIONAL INFORMATION: You requested that the
         Company   include  the  new  corporate   governance  and  board  member
         disclosure.

                  RESPONSE #16: The Company will include such disclosure.

         Should you have any questions  regarding the  foregoing,  please do not
         hesitate  to  contact  Helen  A.  Robichaud  at PNC  Global  Investment
         Servicing, Inc., the Fund's Sub-Administrator, at 617-338-4595.


         Very truly yours,

         Bruce N. Alpert
         Gabelli Funds, LLC

         cc:  Helen A. Robichaud        Arlene Lonergan
              PNC Global Investment     PNC Global Investment
              Servicing, Inc.           Servicing, Inc.

              Peter D. Goldstein        Richard Prins
              Gabelli Funds, LLC        Skadden, Arps, Slate, Meagher & Flom LLP

              Leslie Lowenbraun
              Skadden, Arps, Slate, Meagher & Flom LLP