EXHIBIT 3.1

                           CERTIFICATE OF AMENDMENT OF
                        THE CERTIFICATE OF INCORPORATION
                                       OF
                         POWER 3 MEDICAL PRODUCTS, INC.

                UNDER SECTION 805 OF THE BUSINESS CORPORATION LAW

         Article 1. The name of the Corporation is Power 3 Medical Products,
Inc. f/k/a Sheffeld Acres, Inc. (the "Corporation").

         Article 2. The Certificate of Incorporation of the Corporation was
filed with the Department of State of the State of New York on May 7, 1993.

         Article 3. This Certificate of Amendment of the Certificate of
Incorporation of Power 3 Medical Products, Inc. is filed for the purpose of
amending the Certificate of Incorporation to amend and restate the powers,
designations and relative rights of the Series A Preferred Stock as set forth in
the Certificate of Amendment of the Certificate of Incorporation of Power 3
Medical Products, Inc. dated May 1, 2003. As amended and restated, such powers,
designations and relative rights are as follows:

                  1. Designation and Amount. There shall be a series of
         Preferred Stock designated as "Series A Preferred Stock," and the
         number of shares constituting such series shall be 4,000,000. Such
         series is referred to herein as the "Series A Preferred Stock."

                  2. Stated Capital. The amount to be represented in stated
         capital at all times for each share of Series A Preferred Stock shall
         be $.001.

                  3. Rank. All shares of Series A Preferred Stock shall rank
         prior to all of the Corporation's Common Stock, par value $.001 per
         share (the "Common Stock"), now or hereafter issued, both as to payment
         of dividends and as to distributions of assets upon liquidation,
         dissolution or winding up of the Corporation, whether voluntary or
         involuntary.

                  4. Dividends. If any dividend or other distribution payable in
         cash, securities or other property, including a dividend payable in
         shares of Common Stock, is declared on the Common Stock, each holder of
         shares of Series A Preferred Stock on the record date for such dividend
         or distribution shall be entitled to receive on the date of payment or
         distribution of such dividend or other distribution the same cash,
         securities or other property which such holder would have received on
         such record date if such holder was the holder of record of the number
         (including any fraction) of shares of Common Stock into which the
         shares of Series A Preferred Stock then held by such holder are then
         convertible. No dividend or other distribution shall be declared or
         paid on the Common Stock unless an equivalent dividend or other
         distribution that satisfies this Section 4 is declared or paid on the
         Series A Preferred Stock.



                  5. Liquidation Preference.

                     (a) The liquidation value of shares of this Series A
         Preferred Stock, in case of the voluntary or involuntary liquidation,
         dissolution or winding-up of the Corporation, shall be $.10 per share,
         plus an amount equal to the dividends accrued and unpaid thereon to the
         payment date.

                     (b) In the event of any voluntary or involuntary
         liquidation, dissolution or winding-up of the Corporation, the holders
         of shares of this Series A Preferred Stock shall not be entitled to
         receive the liquidation value of such shares held by them until the
         liquidation value of all Senior Shares shall have been paid in full and
         shall be entitled to receive the liquidation value of such shares held
         by them in preference to and in priority over any distributions upon
         the Common Shares and all Junior Shares. Upon payment in full of the
         liquidation value to which the holders of shares of this Series A
         Preferred Stock are entitled, the holders of shares of this Series A
         Preferred Stock will not be entitled to any further participation in
         any distribution of assets by the Corporation. If the assets of the
         Corporation are not sufficient to pay in full the liquidation value
         payable to the holders of shares of this Series A Preferred Stock and
         the liquidation value payable to the holders of all Parity Shares, the
         holders of all such shares shall share ratably in such distribution of
         assets in accordance with the amounts which would be payable on such
         distribution if the amounts to which the holders of shares of this
         Series A Preferred Stock and the holders of Parity Shares are entitled
         were paid in full.

                     (c) Neither a consolidation or merger of the Corporation
         with or into any other corporation, nor a merger of any other
         corporation with or into the Corporation, nor a sale or transfer of all
         or any part of the Corporation's assets for cash or securities or other
         property shall be considered a liquidation, dissolution or winding-up
         of the Corporation within the meaning of this Paragraph 5.

                  6. Voting Rights. Except as otherwise required by law, holders
         of Series A Preferred Stock are not entitled to vote.

                  7. No Redemption. The shares of Series A Preferred Stock are
         not redeemable.

                  8. Conversion Provisions.

                     (a) Conversion at Option of Holders. Each share of Series A
         Preferred Stock shall be convertible at the option of the holder
         thereof, at any time after October 31, 2004, into fully paid and
         nonassessable shares of Common Stock and such other securities and
         property as hereinafter provided, initially at the rate of .7752 shares
         of Common Stock for each full share of Series A Preferred Stock
         ("Conversion Ratio").

                     For the purpose of this Certificate of Amendment of the
         Certificate of Incorporation, the term "Common Stock" shall initially
         mean the class designated



                                       2


         as Common Stock, par value $.001 per share, of the Corporation as of
         May 5, 2004 subject to adjustment as hereinafter provided.

                     (b) Mechanics of Conversion. Any holder of shares of Series
         A Preferred Stock desiring to convert such shares into Common Stock
         shall surrender the certificate or certificates for such shares of
         Series A Preferred Stock at the office of the transfer agent for the
         Series A Preferred Stock, which certificate or certificates, if the
         Corporation shall so require, shall be duly endorsed to the Corporation
         or in blank, or accompanied by proper instruments of transfer to the
         Corporation or in blank, accompanied by irrevocable written notice to
         the Corporation that the holder elects so to convert such shares of
         Series A Preferred Stock and specifying the name or names (with
         address) in which a certificate or certificates for Common Stock are to
         be issued. No adjustments in respect of any dividend on the Common
         Stock issued upon conversion shall be made upon the conversion of any
         shares of Series A Preferred Stock.

                     Any accrued and unpaid dividends on shares surrendered for
         conversion shall be paid upon the conversion of any shares of Series A
         Preferred Stock by issuing additional shares of Common Stock with an
         aggregate value based upon the Current Market Value (as defined below)
         as of the effective date of conversion equal to all accrued and unpaid
         dividends on the shares of Series A Preferred Stock converted.

                     The Corporation will, as soon as practicable after such
         deposit of certificates for Series A Preferred Stock accompanied by the
         written notice and, compliance with any other conditions herein
         contained, deliver at the office of the transfer agent to the person
         for whose account such shares of Series A Preferred Stock were so
         surrendered, or to his nominee or nominees, certificates for the number
         of full shares of Common Stock to which he shall be entitled as
         aforesaid, together with a cash adjustment of any fraction of a share
         as hereinafter provided. Subject to the following provisions of this
         paragraph, such conversion shall be deemed to have been made as of the
         date of such surrender of the shares of Series A Preferred Stock to be
         converted, and the person or person entitled to receive the Common
         Stock deliverable upon conversion of such Series A Preferred Stock
         shall be treated for all purposes as the record holder or holders of
         such Common Stock on such date; provided, however, that the Corporation
         shall not be required to convert any shares of Series A Preferred Stock
         while the stock transfer books of the Corporation are closed for any
         purpose, but the surrender of Series A Preferred Stock for conversion
         during any period while such books are so closed shall become effective
         for conversion immediately upon the reopening of such books as if the
         surrender had been made on the date of such reopening, and the
         conversion shall be at the conversion rate in effect on such date.

                     (c) The Conversion Ratio shall be subject to adjustment as
         follows:

                         (i) In case the Corporation shall (A) pay a dividend or
                     make a distribution in Common Stock, or (B) subdivide or
                     reclassify its


                                       3


                     outstanding shares of Common Stock into a greater number
                     (but not smaller number) of shares, the Conversion Ratio in
                     effect immediately prior thereto shall be adjusted
                     retroactively as provided below so that the Conversion
                     Ratio thereafter shall be determined by multiplying the
                     Conversion Ratio at which such shares of this Series A
                     Preferred Stock were theretofore convertible by a fraction
                     of which the numerator shall be the number of shares of
                     Common Stock outstanding immediately following such action
                     and of which the denominator shall be the number of shares
                     of Common Stock outstanding immediately prior thereto. Such
                     adjustment shall be made whenever any event listed above
                     shall occur and shall become effective retroactively
                     immediately after the record date in the case of a dividend
                     and shall become effective immediately after the effective
                     date in the case of a subdivision or reclassification.

                          (ii) In case the Corporation shall issue rights or
                     warrants to all holders of its Common Stock entitling them
                     (for a period expiring within 45 days after the record date
                     therefor) to subscribe for or purchase shares of Common
                     Stock at a price per share less than the current market
                     price per share of Common Stock (as determined in
                     accordance with the provisions of subclause (iv) of this
                     clause (d)) at the record date therefor (the "Current
                     Market Price"), or in case the Corporation shall issue
                     other securities convertible into or exchangeable for
                     Common Stock for a consideration per share of Common Stock
                     deliverable upon conversion or exchange thereof less than
                     the Current Market Price; then the Conversion Ratio in
                     effect immediately prior thereto shall be adjusted
                     retroactively as provided below so that the Conversion
                     Ratio therefor shall be equal to the price determined by
                     multiplying the Conversion Ratio at which shares of this
                     Series A Preferred Stock were theretofore convertible by a
                     fraction of which the denominator shall be the number of
                     shares of Common Stock outstanding on the date of issuance
                     of such convertible or exchangeable securities, rights or
                     warrants plus the number of additional shares of Common
                     Stock offered for subscription or purchase and of which the
                     numerator shall be the number of shares of Common Stock
                     outstanding on the date of issuance of such shares,
                     convertible or exchangeable securities, rights or warrants
                     plus the number of additional shares of Common Stock which
                     the aggregate offering price of the number of shares of
                     Common Stock so offered would purchase at the Current
                     Market Price per share of Common Stock (as determined in
                     accordance with the provisions of subclause (iv) of this
                     clause (d)). Such adjustment shall be made whenever such
                     convertible or exchangeable securities rights or warrants
                     are issued, and shall become effective retroactively
                     immediately after the record date for the determination of
                     stockholders entitled to receive such securities. However
                     upon the expiration of any right or warrant to purchase
                     Common Stock the issuance of which resulted in an
                     adjustment in the Conversion Ratio pursuant to this
                     subclause (ii), if any such right or warrant shall expire
                     and shall not have been exercised, the Conversion Ratio
                     shall be recomputed immediately upon such expiration and
                     effective immediately


                                       4


                     upon such expiration shall be increased to the price it
                     would have been (but reflecting any other adjustments to
                     the Conversion Ratio made pursuant to the provisions of
                     this clause (d) after the issuance of such rights or
                     warrants) had the adjustment of the Conversion Ratio made
                     upon the issuance of such rights or warrants been made on
                     the basis of offering for subscription or purchase only
                     that number of shares of Common Stock actually purchased
                     upon the exercise of such rights or warrants actually
                     exercised.

                          (iii) In case the Corporation shall distribute to all
                     holders of its Common Stock (including any such
                     distribution made in connection with a consolidation or
                     merger in which the Corporation is the continuing
                     corporation) shares of capital stock (other than Common
                     Stock), evidences of its indebtedness or assets (excluding
                     cash dividends) or rights to subscribe (excluding those
                     referred to in subclause (ii) of this clause (d)), then in
                     each such case the number of shares of Common Stock into
                     which each share of this Series A Preferred Stock shall
                     thereafter be convertible shall be determined by
                     multiplying the number of shares of Common Stock into which
                     such share of this Series A Preferred Stock was theretofore
                     convertible by a fraction of which the numerator shall be
                     the number of outstanding shares of Common Stock multiplied
                     by the Current Market Price per share of Common Stock (as
                     determined in accordance with the provisions of subclause
                     (iv) of this clause (d)) on the date of such distribution
                     and of which the denominator shall be the product of the
                     number of outstanding shares of Common Stock and the
                     Current Market Price per share of Common Stock, less the
                     aggregate fair market value (as determined by the Board of
                     Directors of the Corporation, whose determination shall be
                     conclusive, and described in a statement filed with the
                     transfer agent for the shares of this Series A Preferred
                     Stock) of the capital stock, assets or evidences of
                     indebtedness so distributed or of such subscription rights.
                     Such adjustment shall be made whenever any such
                     distribution is made, and shall become effective
                     retroactively immediately after the record date for the
                     determination of stockholders entitled to receive such
                     distribution.


                          (iv) For the purpose of any computation under
                     subclause (ii) and (iii) of this clause (d) and under
                     clause (b) above, the Current Market Price per share of
                     Common Stock at any date shall be deemed to be the average
                     Sale Price for the thirty consecutive trading days
                     commencing forty-five trading days before the day in
                     question. As used herein, "Sale Price" means the closing
                     sales price of the Common Stock (or if no sale price is
                     reported, the average of the high and low bid prices) as
                     reported by the principal national or regional stock
                     exchange on which the Common Stock is listed or, if the
                     Common Stock is not listed on a national or regional stock
                     exchange, as reported by national Association of Securities
                     Dealers Automated Quotation System and if not so reported


                                       5


                     then as reported by the Electronic Bulletin Board or the
                     National Quotation Bureau Incorporated.

                          (v) No adjustment in the Conversion Ratio shall be
                     required unless such adjustment would require an increase
                     or decrease of at least 1% in the price then in effect;
                     provided, however, that any adjustments which by reason of
                     this subclause (v) are not required to be made shall be
                     carried forward and taken into account in any subsequent
                     adjustment. All calculations under this Paragraph 8 shall
                     be made to the nearest cent.

                          (vi) In the event that, at any time as a result of an
                     adjustment made pursuant to subclause (i) or subclause
                     (iii) of this clause (d), the holder of any share of this
                     Series A Preferred Stock thereafter surrendered for
                     conversion shall become entitled to receive any shares of
                     the Corporation other than shares of the Common Stock,
                     thereafter the number of such other shares so receivable
                     upon conversion of any share of this Series A Preferred
                     Stock shall be subject to adjustment from time to time in a
                     manner and on the terms as nearly equivalent as practicable
                     to the provisions with respect to the Common Stock
                     contained in subclauses (i) through (v) of this clause (d),
                     and the other provisions of this clause (d) with respect to
                     the Common Stock shall apply on like terms to any such
                     other shares.

                          (vii) Whenever the conversion rate is adjusted, as
                     herein provided, the Corporation shall promptly file with
                     the transfer agent for this Series A Preferred Stock, a
                     certificate of an officer of the Corporation setting forth
                     the conversion rate after such adjustment and setting forth
                     a brief statement of the facts requiring such adjustment
                     and a computation thereof. Such certificate shall be
                     conclusive evidence of the correctness of such adjustment.
                     The Corporation shall promptly cause a notice of the
                     adjusted conversion rate to be mailed to each registered
                     holder of shares of this Series A Preferred Stock.

                     (d) If any of the following events occur, namely (i) any
         reclassification or change (other than a combination of
         reclassification into a smaller number of shares) of outstanding shares
         of Common Stock issuable upon conversion of shares of this Series A
         Preferred Stock (other than a change in par value, or from par value to
         no par value, or from no par value to par value, or as a result of a
         subdivision) or (ii) any consolidation or merger to which the
         Corporation is a party (other than a consolidation or merger to which
         the Corporation is the continuing corporation and which does not result
         in any classification of, or change (other than a change in par value,
         or from par value to no par value, or from no par value to par value,
         or as a result of a subdivision) in, outstanding shares of Common
         Stock); then the Corporation or such successor, as the case may be,
         shall provide in its Certificate of Incorporation that each share of
         this Series A Preferred Stock shall be convertible into the kind and
         amount of shares of stock and other securities or property receivable
         upon such reclassification,


                                       6


         change, consolidation or merger by a holder of the number of shares of
         Common Stock issuable upon conversion of each such share of this Series
         A Preferred Stock immediately prior to such reclassification, change,
         consolidation or merger. Such Certificate of Incorporation shall
         provide for adjustments which shall be as nearly equivalent as may be
         practicable to the adjustments provided for in clause (d). The
         Corporation shall cause notice of the execution of any such event
         contemplated by this clause (d) to be mailed to each holder of shares
         of this Series A Preferred Stock as soon as practicable.

                  The above provisions of this clause (d) shall similarly apply
         to successive reclassifications, consolidations and mergers.

                  9. Protective Provisions.

                     (a) Reservation of Shares; Transfer Taxes; Etc. The
         Corporation shall at all times serve and keep available, out of its
         authorized and unissued stock, solely for the purpose of effecting the
         conversion of the Series A Preferred Stock, such number of shares of
         its Common Stock free of preemptive rights as shall from time to time
         be sufficient to effect the conversion of all shares of Series A
         Preferred Stock from time to time outstanding. The Corporation shall
         from time to time, in accordance with the laws of the State of New
         York, increase the authorized number of shares of Common Stock if at
         any time the number of shares of Common Stock not outstanding shall not
         be sufficient to permit the conversion of all the then outstanding
         shares of Series A Preferred Stock.

                  If any shares of Common Stock required to be reserved for
         purposes of conversion of the Series A Preferred Stock hereunder
         require registration with or approval of any governmental authority
         under any Federal or State law before such shares may be issued upon
         conversion, the Corporation will in good faith and as expeditiously as
         possible endeavor to cause such shares to be duly registered or
         approved, as the case may be. If the Common Stock is listed on the New
         York Stock Exchange or any other national securities exchange, the
         Corporation will, if permitted by the rules of such exchange, list and
         keep listed on such exchange, upon official notice of issuance, all
         shares of Common Stock issuable upon conversion of the Series A
         Preferred Stock.

                  The Corporation will pay any and all issue or other taxes that
         may be payable in respect of any issue or delivery of shares of Common
         Stock on conversion of the Series A Preferred Stock. The Corporation
         shall not, however, be required to pay any tax which may be payable in
         respect of any transfer involved in the issue or delivery of Common
         Stock (or other securities or assets) in a name other than that which
         the shares of Series A Preferred Stock so converted were registered,
         and no such issue or delivery shall be made unless and until the person
         requesting such issue has paid to the Corporation the amount of such
         tax or has established, to the satisfaction of the Corporation, that
         such tax has been paid.


                                       7


                   (b) Prior Notice of Certain Events. In case:

                       (i) The Corporation shall (1) declare any dividend (or
                   any other distribution) on its Common Stock, other than (A) a
                   dividend payable in shares of Common Stock or (B) a dividend
                   payable in cash out of its retained earnings other than any
                   special or nonrecurring or other extraordinary dividend or
                   (2) declare or authorize a redemption or repurchase of in
                   excess of 10% of the than-outstanding shares of Common Stock;
                   or

                       (ii) the Corporation shall authorize the granting to the
                   holders of Common Stock of rights or warrants to subscribe
                   for or purchase any shares of stock of any class or of any
                   other rights or warrants (other than any rights specified in
                   subclause (ii) of clause (d) of this Paragraph 9); or

                       (iii) of any reclassification of Common Stock (other than
                   a subdivision of the outstanding Common Stock, or a change in
                   par value, or from par value to no par value, or from no par
                   value to par value), or of any consolidation or merger to
                   which the Corporation is a party and for which approval of
                   any stockholders of the Corporation shall be required, or of
                   the sale or transfer of all or substantially all of the
                   assets of the Corporation or of any compulsory share exchange
                   whereby the Common Stock is converted into other securities,
                   cash or other property; or

                       (iv) of the voluntary or involuntary dissolution,
                   liquidation or winding up of the Corporation;

         then the Corporation shall cause to be filed with the transfer agent
         for the Series A Preferred Stock, and shall cause to be mailed to the
         holders of record of the Series A Preferred Stock, at their last
         address as they shall appear upon the stock transfer books of the
         Corporation, at least 15 days prior to the applicable record date
         hereinafter specified, a notice stating (x) the date on which a record
         is to be taken for the purpose of such dividend, distribution,
         redemption or granting of rights or warrants or, if a record is not to
         be taken, the date as of which the holders of Common Stock of record to
         be entitled to such dividend, distribution, redemption, rights or
         warrants are to be determined, or (y) the date on which such
         reclassification, consolidation, merger, sale, transfer, share
         exchange, dissolution, liquidation or winding up is expected to become
         effective, and the date as of which it is expected that holders of
         Common Stock of record shall be entitled to exchange their shares of
         Common Stock for securities or other property deliverable upon such
         reclassification, consolidation, merger, sale, transfer, share
         exchange, dissolution, liquidation or winding up (but no failure to
         mail such notice or any defect therein or in the mailing thereof shall
         affect the validity of the corporate action required to be specified in
         such notice).

                  (c) Class Voting Rights. So long as the Series A Preferred
         Stock is outstanding, the Corporation shall not, without the
         affirmative vote or consent of


                                       8


         the holders of at least a majority of all outstanding Series A
         Preferred Stock voting separately as a class, (i) amend, alter or
         repeal (by merger or otherwise) any provision of the Articles of
         Incorporation or the By-Laws of the Corporation, as amended, so as
         adversely to affect the relative rights, preferences, qualifications,
         limitations or restrictions of the Series A Preferred Stock, (ii)
         authorize or issue, or increase the authorized amount of, any
         additional class or series of stock, or any security convertible into
         stock of such class or series, ranking prior to the Series A Preferred
         Stock in respect of the payment of dividends or upon liquidation,
         dissolution or winding up of the Corporation or (iii) effect any
         reclassification of the Series A Preferred Stock. A class vote on the
         part of the Series A Preferred Stock shall, without limitation,
         specifically not be deemed to be required (except as otherwise required
         by law or resolution of the Corporation's Board of Directors) in
         connection with: (a) the authorization, issuance or increase in the
         authorized amount of any shares of any other class or series of stock
         which ranks junior to, or on a parity with, the Series A Preferred
         Stock in respect of the payment of dividends and distributions upon
         liquidation, dissolution or winding up of the Corporation; or (b) the
         authorization, issuance or increase in the amount of any bonds,
         mortgages, debentures or other obligations of the Corporation.

                  The affirmative vote or consent of the holders of a majority
         of the outstanding Series A Preferred Stock, voting or consenting
         separately as a class, shall be required to (a) authorize any sale,
         lease or conveyance of all or substantially all of the assets of the
         Corporation, or (b) approve any merger, consolidation or compulsory
         share exchange of the Corporation with or into any other person unless
         (i) the terms of such merger, consolidation or compulsory share
         exchange do not provide for a change in the terms of the Series A
         Preferred Stock and (ii) the Series A Preferred Stock is, after such
         merger, consolidation or compulsory share exchange on a parity with or
         prior to any other class or series of capital stock authorized by the
         surviving corporation as to dividends and upon liquidation, dissolution
         or winding up other than any class or series of stock of the
         Corporation prior to the Series A Preferred Stock as may have been
         created with the affirmative vote or consent of the holders of at least
         66-2/3% of the Series A Preferred Stock (or other than a class or
         series into which such prior stock is converted as a result of such
         merger, consolidation or share exchange).

         10. Outstanding Shares. For purposes of this Certificate of
Designation, all shares of Series A Preferred Stock shall be deemed outstanding
except (i) from the date of surrender of certificates representing shares of
Series A Preferred Stock, all shares of Series A Preferred Stock converted into
Common Stock; (ii) from the date of registration of transfer, all shares of
Series A Preferred Stock held of record by the Corporation or any subsidiary of
the Corporation.

         11. Certain Definitions. As used in this Certificate, the following
terms shall have the following respective meanings:


                                       9


                  "Affiliate" of any specified person means any other person
         directly or indirectly controlling or controlled by or under common
         control with such specified person. For purposes of this definition,
         "control" when used with respect to any person means the power to
         direct the management and policies of such person, directly or
         indirectly, whether through the ownership of voting securities or
         otherwise; and the term "controlling" and "controlled" having meanings
         correlative to the foregoing.

                  "Common Shares" shall mean any stock of the Corporation which
         has no preference in respect of dividends or of amounts payable in the
         event of any voluntary or involuntary liquidation, dissolution or
         winding-up of the Corporation and which is not subject to redemption by
         the Corporation. However, Common Shares issuable upon conversion of
         shares of this Series A Preferred Stock shall include only shares of
         the class designated as common Shares as of the original date of
         issuance of shares of this Series A Preferred Stock, or shares of the
         Corporation of any class or classes resulting from any reclassification
         or reclassifications thereof and which have no preference in respect of
         dividends or of amounts payable in the event of any voluntary or
         involuntary liquidation, dissolution or winding-up of the Corporation
         and which are not subject to redemption by the Corporation; provided
         that if at any time there shall be more than one such resulting class,
         the shares of each such class then so issuable shall be substantially
         in the proportion which the total number of shares of such class
         resulting from such reclassifications bears to the total number of
         shares of all classes resulting from all such reclassifications.

                  "Junior Shares" shall mean shares of any series or class of
         the Corporation which are by their terms expressly made junior to
         shares of this Series A Preferred Stock at the time outstanding either
         as to dividends or as to the distribution of assets on any voluntary or
         involuntary liquidation of the Corporation.

                  "Parity Shares" shall mean shares which are by their terms on
         a parity with the shares of this Series A Preferred Stock at the time
         outstanding both as to dividends and as to the distribution of assets
         on any voluntary or involuntary liquidation of the Corporation. For
         purposes of this Paragraph 11 Parity Shares shall mean shares which are
         by their terms on a parity with the shares of this Series A Preferred
         Stock at the time outstanding as to dividends regardless of such shares
         preference with respect to liquidation.

                  "Senior Shares" shall mean any class of shares of the
         Corporation ranking prior to at least one other class of shares of the
         Corporation as to dividends for purposes of Paragraph 4 and the
         distribution of assets on any voluntary or involuntary liquidation of
         the Corporation for purposes of Paragraph 5.

                  12. Securities Not Registered Under the Securities Act of
         1933. Neither the shares of Series A Preferred Stock nor the Common
         Stock issuable upon conversion thereof has been registered under the
         Securities Act of 1933 or the laws of any state of the United States
         and may not be transferred without such registration or an exemption
         from registration.


                                       10


                  (a) Restrictive Legends. Each share of Series A Preferred
         Stock and certificate for Common Stock issued upon the conversion of
         any shares of Series A Preferred Stock, and each preferred stock
         certificate issued upon the transfer of any such shares of Series A
         Preferred Stock or Common Stock (except as otherwise permitted by this
         Section 12), shall be stamped or otherwise imprinted with a legend in
         substantially the following form:

         "The securities represented hereby have not been registered under the
         Securities Act of 1933. Such securities may not be sold or transferred
         in the absence of such registration or an exemption therefrom under
         said Act."

                  (b) Notice of Proposed Transfer; Opinions of Counsel. Except
         as provided in Paragraph (c) of this Section 11, prior to any transfer
         of any such shares of Series A Preferred Stock, or Common Stock, the
         holder thereof will give written notice to the Corporation of such
         holder's intention to effect such transfer and to comply in all other
         respects with this Section 11. Each such notice (A) shall describe the
         manner and circumstances of the proposed transfer in sufficient detail
         to enable counsel to render the opinions referred to below, and (B)
         shall designate counsel for the holder giving such notice (who may be
         house counsel for such holder). The holder giving such notice will
         submit a copy thereof to the counsel designated in such notice and the
         Corporation will promptly submit a copy thereof to its counsel, and the
         following provisions shall apply:

                           (i) If in the opinion of each such counsel the
                  proposed transfer of such shares of Series A Preferred Stock
                  or Common Stock may be effected without registration under the
                  Act, the Corporation will promptly notify the holder thereof
                  and such holder shall thereupon be entitled to transfer such
                  shares of Series A Preferred Stock or Common Stock in
                  accordance with the terms of the notice delivered by such
                  holder to the Corporation. Each share of Series A Preferred
                  Stock or certificate, if any, issued upon or in connection
                  with such transfer shall bear the appropriate restrictive
                  legend set forth in Paragraph (a) of this Section 12, unless
                  in the opinion of each such counsel such legend is no longer
                  required to insure compliance with the Act. Except as provided
                  in subclause (ii) below, if for any reason counsel for the
                  Corporation (after having been furnished with the information
                  required to be furnished by this Paragraph (b)) shall fail to
                  deliver an opinion of the Corporation, or the Corporation
                  shall fail to notify such holder thereof as aforesaid, within
                  20 days after counsel for such holder shall have delivered its
                  opinion to such holder (with a copy to the Corporation), then
                  for all purposes of this Certificate of Designation the
                  opinion of counsel for the Corporation shall be deemed to be
                  the same as the opinion of counsel for such holder.

                           (ii) If in the opinion of either or both of such
                  counsel the proposed transfer of such shares of Series A
                  Preferred Stock or Common Stock may not be effected without
                  registration under the Act, the


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                  Corporation will promptly so notify the holder thereof and
                  thereafter such holder shall not be entitled to transfer such
                  share of Series A Preferred Stock or Common Stock until
                  receipt of a further notice from the Corporation under
                  subclause (i) above or, in the case of Common Stock, until
                  registration of such Common stock under the Act has become
                  effective.

                  13. Preemptive Rights. The Series A Preferred Stock is not
         entitled to any preemptive or subscription rights in respect of any
         securities of the Corporation.

                  14. Severability of Provisions. Whenever possible, each
         provision hereof shall be interpreted in a manner as to be effective
         and valid under applicable law, but if any provision hereof is held to
         be prohibited by or invalid under applicable law, such provision shall
         be ineffective only the extent of such prohibition or invalidity,
         without invalidating or otherwise adversely affecting the remaining
         provisions hereof. If a court of competent jurisdiction should
         determine that a provision hereof would be valid or enforceable if a
         period of time were extended or shortened or a particular percentage
         were increased or decreased, then such court may make such change as
         shall be necessary to render the provision in question effective and
         valid under applicable law.

         Article 4. This Certificate of Amendment of the Certificate of
Incorporation was authorized by the Board of Directors pursuant to Section 708
of the New York Business Corporation Law and by the holders of the outstanding
Series A Preferred Stock pursuant to Section 804 of the New York Business
Corporation Law.

         IN WITNESS WHEREOF, Power 3 Medical Products, Inc. has caused this
certificate to be signed by its Chief Executive Officer as of the 28th day of
October, 2004.

                                      POWER 3 MEDICAL PRODUCTS, INC.



                                      By:      /s/ Steven B. Rash
                                               ---------------------------------
                                      Name:    Steven B. Rash
                                      Title:   Chief Executive Officer







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