POWER OF ATTORNEY

The undersigned, as a Section 16 reporting person
of Pacific Biosciences of California, Inc. (the "Company"),
hereby constitutes and appoints Susan Kim, Brett Atkins,
Michele Farmer and Andrew Hoffman, and each of them,
the undersigned's true and lawful attorney-in-fact to:

1. complete and execute Forms 3, 4 and 5 and other
forms and all amendments thereto as such attorney-in-fact
shall in his or her discretion determine to be required or
advisable pursuant to Section 16 of the Securities Exchange
Act of 1934 (as amended) and the rules and regulations promulgated
thereunder, or any successor laws and regulations, as a
consequence of the undersigned's ownership, acquisition
or disposition of securities of the Company; and

2.  do all acts necessary in order to file such forms
with the U.S. Securities and Exchange Commission, any
securities exchange or national association, the
Company and such other person or agency as the
attorney-in-fact shall deem appropriate.

The undersigned hereby ratifies and confirms all
that said attorneys-in-fact and agents shall do
or cause to be done by virtue hereof. The undersigned
acknowledges that the foregoing attorneys-in-fact,
in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company
assuming, any of the undersigned's responsibilities
to comply with Section 16 of the Securities Exchange
Act of 1934 (as amended).

This Power of Attorney shall remain in full force
and effect until the undersigned is no longer required
to file Forms 3, 4 and 5 with respect to the
undersigned's holdings of and transactions in
securities issued by the Company, unless earlier
revoked by the undersigned in a signed writing
delivered to the Company and the
foregoing attorneys-in-fact.

IN WITNESS WHEREOF, the undersigned has caused
this Power of Attorney to be executed as of
March 4, 2022.


Signature: /s/ Peter Fromen

Name: Peter Fromen