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WAT Waters

APP
Utility
Multiple Sample Channel Device for Liquid Chromatography
25 Nov 21
Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels.
Sylvain Gilles Cormier, Charles T. Murphy, Joseph D. Michienzi
Filed: 20 May 21
GRANT
Utility
Multi-stage displacement pump
23 Nov 21
Described is a multi-stage pump having at least two stages.
Wade P. Leveille, Jacob N. Fairchild, Jeffrey Musacchio, Joseph D. Michienzi
Filed: 18 Jun 19
GRANT
Utility
Materials and methods for trap-elute mixed mode chromatography
16 Nov 21
In various aspects, the present disclosure pertains to materials (e.g., kits, column assemblies, liquid chromatography systems, etc.) methods for performing liquid chromatography that employ a first column (e.g., a trapping column) and a second column (e.g., an analytical column).
Matthew A. Lauber, Babajide O. Okandeji
Filed: 9 Jul 19
GRANT
Utility
Methods for preparing liquid mixtures
16 Nov 21
A method of preparing a liquid mixture for use in a liquid chromatography system is provided.
Thomas E. Wheat, Patricia McConville, John R. Lamoureux, Aparna Chavali
Filed: 14 Aug 19
APP
Utility
Methods for Heat-assisted Enzyme Digestion
11 Nov 21
The present disclosure relates to a method of digesting a sample comprising protein, the method comprising: adding the sample to an apparatus containing a buffer and a solid support surface comprising a surface coating, wherein the surface coating immobilizes enzyme while reducing undesired interactions between the sample and the solid support surface; immobilizing enzymes on the surface coating for digestion of the protein of the sample; and heating the sample to complete a heat-assisted digestion of the protein.
Wenjing Li, Beatrice Muriithi, Anna Boardman, Matthew A. Lauber
Filed: 7 May 21
APP
Utility
Hetero-functional Coating for Conjugating Biomolecules on a Solid Support and Use Thereof for Bio Analysis
11 Nov 21
The present disclosure relates to a hetero-functional coating applied on a solid support.
Beatrice Muriithi, Wenjing Li, Oksana D. Tchoul, Matthew A. Lauber, Darryl W. Brousmiche
Filed: 7 May 21
APP
Utility
Multidimensional Liquid Chromatography System
11 Nov 21
Described are multidimensional liquid chromatography (MDLC) systems and methods of performing MDLC.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 4 May 21
APP
Utility
Liquid Chromatography Based Detection and Quantitation of Phospho Prodrugs and Their Active Metabolites
11 Nov 21
The present disclosure relates to the use of vapor deposition coated flow paths for improved chromatography and sample analysis using liquid chromatography-mass spectrometry (LC/MS) or liquid chromatography-optical detection (LC/UV).
Matthew A. Lauber, Kevin Wyndham, Bonnie Alden, Dominic Foley, David Morrissey
Filed: 5 May 21
GRANT
Utility
Mass spectrometer ion source with integrated column
9 Nov 21
Techniques and apparatus for ion source devices with minimized post-column volumes are described.
Michael O. Fogwill, Curt Devlin, Theodore A. Dourdeville, Jacob N. Fairchild, Geoff C. Gerhardt, Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio
Filed: 15 Apr 19
APP
Utility
Differentiation of Natural Vitamin E from Synthetic Vitamin E and Quantification of Tocopherols by Supercritical Fluid Chromatography
4 Nov 21
The present disclosure provides methods for the separation and quantitation of enantiomers of vitamin E using supercritical fluid chromatography (SFC) or carbon dioxide-based chromatography on chiral columns.
Jinchuan Yang, Paul Rainville
Filed: 29 Apr 21
APP
Utility
Seal for Separation Device
4 Nov 21
Described are apparatuses, devices, and systems implementing seals for separation devices.
Jonathan L. Belanger, Wade P. Leveille, Michael O. Fogwill, Joseph D. Michienzi, Jeffrey Musacchio
Filed: 27 Apr 21
APP
Utility
System and Method for Solvent Mixing In a Chromatography System
4 Nov 21
A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer.
Neal Almeida
Filed: 27 Apr 21
APP
Utility
Establishing Fluidic Connections Between Chromatography Components
4 Nov 21
A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism.
Wade P. Leveille, Joseph D. Michienzi, Joseph D. Antocci, Jeffrey Musacchio
Filed: 26 Apr 21
GRANT
Utility
Device for solid phase extraction and method for use thereof
2 Nov 21
Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis.
Pamela C. Iraneta, Xin Zhang, Frank John Marszalkowski, Jr.
Filed: 16 Dec 15
GRANT
Utility
Filtration device for chromatographic instruments
2 Nov 21
A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material.
Kevin D. Wyndham, Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille, Sr.
Filed: 5 Apr 19
GRANT
Utility
Variable output liquid chromatography pump drive
2 Nov 21
Disclosed is a liquid chromatography solvent pump including a motor, a first piston, a second piston, and a variable output drive system coupling the motor to at least one of the first piston and the second piston.
Jeffrey Musacchio, Joseph Michienzi
Filed: 17 Sep 19
GRANT
Utility
Twist lock compliant needle for detection of contact
2 Nov 21
A twist-lock compliant needle including a housing component surrounding a needle holder holding a rigidly mounted needle, the housing component including a biasing element disposed therein, wherein the biasing element compresses as a needle tip of the needle contacts a surface is provided.
David A. Simpson, Joshua A. Burnett, John M. Auclair
Filed: 16 Jul 19
APP
Utility
Chromatographic Materials
28 Oct 21
In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1).
Kevin D. Wyndham, Michael F. Morris, Darryl W. Brousmiche, Jason F. Hill, Jacob N. Fairchild
Filed: 21 Jun 21
GRANT
Utility
Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
26 Oct 21
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein.
Laks Iyer, Beatrice W. Muriithi
Filed: 21 Mar 19
APP
Utility
Sec Performance Enhancing Conditioning and Storage Solvents Containing Low Levels of Buffer and Salt
21 Oct 21
This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC).
Pamela C. Iraneta, Stephen James Shiner, Raymond P. Fisk, Lavelay Kizekai
Filed: 15 Apr 21
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