426 patents
Page 15 of 22
Utility
Methods to Increase Sensitivity of LC/MS Analysis
22 Jul 21
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy.
Paul Rainville, Kerri Smith
Filed: 15 Jan 21
Utility
Porous Materials for Solid Phase Extraction and Chromatography and Processes for Preparation and Use Thereof
22 Jul 21
The present invention provides porous materials for use in solid phase extractions and chromatography.
Mingcheng Xu, Darryl W. Brousmiche, Kevin Wyndham
Filed: 2 Apr 21
Utility
Use of Vapor Deposition Coated Flow Paths for Improved Chromatography of Metal Interacting Analytes
22 Jul 21
A chromatographic device including a coated metallic frit is disclosed.
Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham, Michael O. Fogwill
Filed: 17 Mar 21
Utility
Fixture Identification In Test Systems
22 Jul 21
Described are systems and methods for fixture identification in test systems.
David L. Dingmann
Filed: 15 Jan 21
Utility
Chromatographic materials
13 Jul 21
In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1).
Kevin D. Wyndham, Michael F. Morris, Darryl W. Brousmiche, Jason F. Hill, Jacob N. Fairchild
Filed: 20 Mar 19
Utility
Method and apparatus for injecting a chromatographic sample
13 Jul 21
Described are a method and apparatus for diluting a chromatographic sample.
Martin Gilar, Keith Fadgen, Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews, Geoff C. Gerhardt, Jordan Kornfeld, Thomas S. McDonald
Filed: 15 Oct 19
Utility
Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced MS signals
13 Jul 21
Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
Compositions, Devices, Kits and Methods Useful for Removal of Phospholipids
8 Jul 21
Novel compositions, devices, kits and methods useful for sample treatment are disclosed herein.
Edouard S. P. Bouvier, Erin E. Chambers
Filed: 8 Jan 21
Utility
Multi- Injection Mode Valve Module
8 Jul 21
A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions.
Sylvain Cormier, Richard W. Andrews, Peyton C. Beals
Filed: 19 Mar 21
Utility
Micro Solid Phase Extraction Devices and Methods
1 Jul 21
Sample preparation and separation can be performed using a sample cartridge (201).
Martin Gilar, Thomas S. McDonald, Joseph D. Michienzi, Jeffrey Musacchio, Rachel Mumma, Keith Fadgen, Geoff C. Gerhardt
Filed: 20 May 19
Utility
Micro Solid Phase Extraction Devices and Methods
1 Jul 21
Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
Martin Gilar, Thomas S. McDonald, Joseph D. Michienzi, Jeffrey Musacchio, Rachel Mumma, Keith Fadgen, Geoff C. Gerhardt
Filed: 20 May 19
Utility
Heat Flow Rate Determination for a Single Sample Differential Scanning Calorimeter
24 Jun 21
A method and a calorimeter system for reducing error in a measured sample heat flow rate due to interpan heat exchange are described.
Robert L. Danley
Filed: 24 Nov 20
Utility
Sample Metering and Injection for Liquid Chromatography
24 Jun 21
Described are a method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow.
Joshua A. Burnett, Rose Solow, David A. Simpson
Filed: 18 Dec 20
Utility
High surface area chromatographic device with low pressure drop
22 Jun 21
A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective.
Abhijit Tarafder, Moon Chul Jung, Edouard S. P. Bouvier
Filed: 5 Mar 19
Utility
Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
15 Jun 21
Solutions, detection methods and chromatographic systems are provided for electrospray ionization of glycans modified with amphipathic, strongly basic moieties.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
Polyanionic Acids to Improve Recovery and Minimize System Loss
10 Jun 21
The present technology relates to a method of separating a sample comprising oligonucleotides.
Michael Donegan, Martin Gilar, Matthew Lauber, Scott Mccall, Pamela Iraneta, Kerri Smith
Filed: 4 Dec 20
Utility
Porous Inorganic/organic Hybrid Materials with Ordered Domains for Chromatographic Separations and Processes for Their Preparation
10 Jun 21
Porous hybrid inorganic/organic materials comprising ordered domains are disclosed.
Kevin D. Wyndham, John E. O'Gara
Filed: 14 Sep 20
Utility
Chelator Based Eluents for Solid Phase Extraction of Phosphorylated Compounds
10 Jun 21
The present technology relates to a method for improved recovery of phosphorylated compounds (e.g., phosphorylated glycans).
Xiaoxiao Liu, Matthew Lauber, Michael Donegan
Filed: 4 Dec 20
Utility
Use of Vapor Deposition Coated Flow Paths for Improved Chromatography of Metal Interacting Analytes
3 Jun 21
A chromatographic device including a coated metallic frit is disclosed.
Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
Filed: 3 Feb 21
Utility
Methods for scaling between chromatographic systems using highly compressible fluids
1 Jun 21
Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile.
Jason F. Hill, Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Abhijit Tarafder
Filed: 9 Apr 18