426 patents
Page 2 of 22
Utility
Dual Stationary Phase Gradient Columns for New Selectivities In Liquid Chromatography
16 Nov 23
The present disclosure is directed to liquid chromatography columns and methods utilizing a stationary phase sorbent having two or more gradient factors.
Szabolcs Fekete, Matthew A. Lauber
Filed: 12 May 23
Utility
Method of Analysis of Polynucleotides by Restricted Access Reversed Phase Chromatography
16 Nov 23
The present disclosure discusses a method of separating and/or purifying polynucleotides.
Matthew A. Lauber, Catalin Doneanu, Weibin Chen, Ying Qing Yu, Jennifer M. Nguyen, Fabrice Gritti, Martin Gilar
Filed: 8 May 23
Utility
Fluidic Configuration for a Multidimensional Liquid Chromatography System
16 Nov 23
Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 25 Jul 23
Utility
Fluidic Network for Aseptic Sampling
9 Nov 23
Described are a fluidic network and a method for aseptic process sampling.
Sylvain Gilles Cormier
Filed: 3 May 23
Utility
Fluidic Network for Positive Displacement Aseptic Sampling
9 Nov 23
Described are a fluidic network and method for aseptic sampling from a process source.
Sylvain Gilles Cormier, Michael O. Fogwill
Filed: 3 May 23
Utility
Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry
31 Oct 23
The present disclosure relates to a streamlined, complete workflow for the qualitative and the quantitative analysis of conjugated peptides from antibody-drug conjugate (ADC) compounds.
Liuxi Chen, Weibin Chen, Steven Cubbedge
Filed: 2 Mar 17
Utility
Multiple sample differential scanning calorimeter
24 Oct 23
A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided.
Robert L. Danley
Filed: 10 Nov 21
Utility
Establishing fluidic connections between chromatography components
24 Oct 23
A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism.
Wade P. Leveille, Joseph D. Michienzi, Joseph D. Antocci, Jeffrey Musacchio
Filed: 26 Apr 21
Utility
Sprayer assembly for DESI applications
24 Oct 23
A sprayer assembly for an ion source is disclosed.
Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio, Emrys Jones, Steven Derek Pringle, Stephen Hattan, Gregory T. Roman
Filed: 22 Jan 21
Utility
Solvent reservoir configuration for steady flow and monitoring solvent level and density
17 Oct 23
Disclosed herein are solvent reservoir systems for steady flow delivery and simultaneous monitoring of solvent level and solvent density within the solvent reservoir systems and methods for monitoring the solvent reservoir systems and providing feedback to a user or adjusting the systems in response to the monitored characteristics.
Sean Eric Anderson
Filed: 7 Jun 21
Utility
Fitting for fluidic coupling in a chromatography system
10 Oct 23
A fitting for fluidic coupling in a chromatography system includes a compression screw including an axial bore, a threaded portion, and a drive end, a tube assembly including a tube sleeve and an inner tube disposed through the sleeve, the tube sleeve and the inner tube each extending to an endface of the tube assembly, the tube sleeve including an outer surface, a seal body extending between a first endface and a second endface, the first endface abutting the endface of the tube assembly, the seal body including an outer surface, and a collar secured to the outer surface of the tube sleeve and the outer surface of the seal body.
Mark W. Moeller, William B. Clark, Charles T. Murphy
Filed: 12 Aug 20
Utility
Metering pump for liquid chromatography
3 Oct 23
Described is a metering pump that may be used to meter volumes of sample in a chromatography system.
Joshua A. Burnett, Rose Solow, David A. Simpson, Peter Osswald, John M. Auclair, Michael LeBeau
Filed: 25 Mar 21
Utility
Sample Manager, System and Method
28 Sep 23
A method of aspirating a sample includes moving a sample needle downward to a first position so a tip of the sample needle touches a bottom of the sample container, determining that the tip of the sample needle is in the first position where the sample needle is in contact with the bottom of the sample container, after the determining that the tip of the sample needle is in contact with the bottom of the sample container, incrementally moving the sample needle upward from the first position, determining the sample needle has moved a predetermined distance upward from the first position and then aspirating a sample in the sample container.
David Zielinski
Filed: 23 Mar 23
Utility
Superficially Porous Materials Comprising a Coated Core Having Narrow Particle Size Distribution; Process for the Preparation Thereof; and Use Thereof for Chromatographic Separations
21 Sep 23
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Nicole L. Lawrence, Daniel P. Walsh, Jacob Nathan Fairchild, Kevin Daniel Wyndham
Filed: 3 May 23
Utility
Aptamer Based Affinity Capture Methods for the Selective Enrichment of Human Immunoglobulin FC Domains
21 Sep 23
A method of capturing human immunoglobulin Fc domains in a biofluid sample is provided.
Xiaoxiao Liu, Matthew A. Lauber
Filed: 6 Jan 23
Utility
Coaxial introduction of calibrant in a flow path with analyte to an ion source
19 Sep 23
Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS).
Michael O. Fogwill, Joseph D. Michienzi, Sylvain Gilles Cormier
Filed: 14 Apr 21
Utility
RPLC-based peptide mapping chromatographic performance using metal chelators as mobile phase additives
19 Sep 23
The present technology relates to a method of analyzing a sample including an analyte.
Robert Birdsall, Ying Qing Yu, Jacob Kellett
Filed: 5 Jun 20
Utility
Methods for liquid chromatography calibration for rapid labeled N-glycans
5 Sep 23
Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography.
Michael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche
Filed: 25 Oct 19
Utility
Fluidic configuration for a multidimensional liquid chromatography system
5 Sep 23
Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 4 May 21
Utility
Methods of use for low-bind polypropylene plates and vials
5 Sep 23
The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule.
Moon Chul Jung, Mary Elizabeth Lame, Caitlin Dunning, Christopher John Hughes, Xiaoxiao Liu, Paula Orens, Yun Wang Alelyunas, Erin E. Chambers, David Dao, Robert Birdsall
Filed: 3 Mar 20