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Waters (WAT)

273 patents

Page 5 of 14
Utility
Twist lock compliant needle for detection of contact
2 Nov 21
A twist-lock compliant needle including a housing component surrounding a needle holder holding a rigidly mounted needle, the housing component including a biasing element disposed therein, wherein the biasing element compresses as a needle tip of the needle contacts a surface is provided.
David A. Simpson, Joshua A. Burnett, John M. Auclair
Filed: 16 Jul 19
Utility
Chromatographic Materials
28 Oct 21
In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1).
Kevin D. Wyndham, Michael F. Morris, Darryl W. Brousmiche, Jason F. Hill, Jacob N. Fairchild
Filed: 21 Jun 21
Utility
Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
26 Oct 21
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein.
Laks Iyer, Beatrice W. Muriithi
Filed: 21 Mar 19
Utility
Sec Performance Enhancing Conditioning and Storage Solvents Containing Low Levels of Buffer and Salt
21 Oct 21
This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC).
Pamela C. Iraneta, Stephen James Shiner, Raymond P. Fisk, Lavelay Kizekai
Filed: 15 Apr 21
Utility
Guard Column Configurations for Size Exclusion Chromatography Separations
21 Oct 21
Chromatographic systems for size exclusion chromatography (SEC) are provided that comprise an inlet, an outlet, an analytic column having a first interior volume that has a first length and a first cross-sectional area normal to the first length, the first interior volume containing a first stationary phase, and a guard column having a second interior volume that has a second length and a second cross-sectional area normal to the second length, the second interior volume containing a second stationary phase.
Stephen James Shiner, Frank J. Marszalkowski, Jr., Steven M. Byrd, Raymond P. Fisk, Mathew H. DeLano, Lavelay Kizekai
Filed: 15 Apr 21
Utility
Multidimensional chromatography method for analysis of antibody-drug conjugates
19 Oct 21
The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
Robert Birdsall
Filed: 8 Sep 16
Utility
System and method for sample introduction within a chromatography system
19 Oct 21
The present disclosure relates to methodologies, systems, apparatus, and kits for introducing a sample within a chromatography system.
Michael O. Fogwill, Joseph D. Michienzi
Filed: 29 May 19
Utility
Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
19 Oct 21
Methods for preparing labeled glycosylamines from a complex matrix are provided.
Matthew A. Lauber
Filed: 19 Jun 17
Utility
Dynamically Adjusting Set Points for a Heating/cooling Element of a Chromatography Column Using Available Information
14 Oct 21
The exemplary embodiments may determine a temperature set point for an outlet heater or cooler based on available information without requiring user input or requiring only minimal user input.
Michael O. Fogwill, Jason F. Hill, Fabrice Gritti
Filed: 14 Apr 21
Utility
Ion Detector
14 Oct 21
An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.
Joseph A. Jarrell, Martin Gilar
Filed: 8 Apr 21
Utility
Coaxial Introduction of Calibrant In a Flow Path with Analyte to an Ion Source
14 Oct 21
Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS).
Michael O. Fogwill, Joseph D. Michienzi, Sylvain Gilles Cormier
Filed: 14 Apr 21
Utility
Systems, methods and devices for decreasing solubility problems in chromatography
12 Oct 21
A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line.
Abhijit Tarafder
Filed: 19 Oct 16
Utility
Systems, devices, and methods for controlling the temperature of a CO2 pump
12 Oct 21
Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO2 based chromatography system.
Abhijit Tarafder, Jason Hill, Joshua Shreve
Filed: 26 Oct 18
Utility
Method and an apparatus for analyzing a complex sample
5 Oct 21
A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time.
Scott J. Geromanos, Marc V. Gorenstein, Daniel Golick, Steven J. Ciavarini
Filed: 19 May 20
Utility
Devices and Methods for the Sensitive Detection and Quantitation of Biomolecules
30 Sep 21
The present disclosure provides devices, systems, kits and methods useful for quantitation of biomolecules such as intact proteins and nucleic acids.
Jennifer M. Nguyen, Matthew A. Lauber, Yun Wang Alelyunas, Gregory T. Roman, Henry Y. Shion
Filed: 24 Mar 21
Utility
Sample Automation Manager
30 Sep 21
A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column.
Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, JR.
Filed: 23 Mar 21
Utility
Large Volume Sample Injection for Liquid Chromatography
30 Sep 21
Described are methods and fluidic networks for injecting a sample into a liquid chromatography system.
Sylvain Gilles Cormier, Jason F. Hill
Filed: 24 Mar 21
Utility
Metering Pump for Liquid Chromatography
30 Sep 21
Described is a metering pump that may be used to meter volumes of sample in a chromatography system.
Joshua A. Burnett, Rose Solow, David A. Simpson, Peter Osswald, John M. Auclair, Michael LeBeau
Filed: 25 Mar 21
Utility
Hybrid gradient delivery system and operation
28 Sep 21
A solvent delivery system for a liquid chromatography system may include a first gradient proportioning valve in fluidic communication with a first plurality of sources of solvent and producing therefrom a first low-pressure gradient stream.
Joseph A. Luongo, Craig Hamilton Dobbs
Filed: 12 Mar 19
Utility
Sample Manager, System and Method
23 Sep 21
A liquid chromatography sample manager includes a sampling mechanism; a sample platter mounted in the sampling mechanism, the sample platter configured to rotate about a first vertical axis; a needle arm mounted within the sampling mechanism, the needle arm configured to rotate about a second vertical axis; and a sample delivery system in fluidic communication with solvent delivery system, the sample delivery system including a sample needle attached to the needle arm, the sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.
Joshua A. Burnett, Rose Solow, David A. Simpson, Marc E. Lemelin
Filed: 16 Mar 21
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