426 patents
Page 7 of 22
Utility
Compositions, Kits and Methods Useful for Analyzing Antibody-containing Samples
1 Sep 22
In some aspects, the present disclosure pertains to sample treatment methods that comprise: contacting an acidic elution solution that is free of primary amine, secondary amine and thiol groups with a sorbent having bound target antibody and separating the elution solution from the sorbent, thereby releasing bound target antibody from the sorbent and forming a first collection fraction that comprises the elution solution and released target antibody; contacting the sorbent with a neutralization buffer solution that is free of primary amine, secondary amine and thiol groups and separating the neutralization buffer solution from the sorbent, thereby forming a second collection fraction that comprises the neutralization buffer solution; and forming a neutralized solution that comprises the first collection fraction and the second collection fraction.
Matthew A. Lauber, Xiaoxiao Liu
Filed: 3 Feb 22
Utility
Composite materials containing nanoparticles and their use in chromatography
30 Aug 22
Novel porous materials comprising nanoparticles, use in chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material are described by the instant invention.
Kevin D. Wyndham, Nicole L. Lawrence
Filed: 1 Feb 16
Utility
Establishing fluidic connections between chromatography components
30 Aug 22
A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly.
Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan Hill, Raymond P. Fisk, Jonathan Belanger, Wade P. Leveille
Filed: 17 May 19
Utility
Methods for Peptide Mapping of Adeno-associated Virus (Aav) Proteins
25 Aug 22
The present disclosure relates to a method of characterizing proteins in a sample.
Ximo Zhang, Stephan M. Koza, Ying Qing Yu, Weibin Chen
Filed: 7 May 21
Utility
Methods and Kits for Universal Calibration of Lateral Flow Testing
25 Aug 22
The present disclosure provides methods and kits for detecting an analyte within a sample by using lateral flow testing.
Lingyun Chen, Justine Yu
Filed: 16 Feb 22
Utility
Methods for the Rapid Preparation of Labeled Glycosylamines and for the Analysis of Glycosylated Biomolecules Producing the Same
25 Aug 22
Methods of analyzing glycosylated biomolecules include the steps of producing a deglycosylation mixture of biomolecules deglycosylated by natural or synthetic enzymatic or chemical techniques; providing a reagent solution having a labeling reagent in a polar aprotic, non-nucleophilic organic solvent; and mixing the deglycosylation mixture with the reagent solution in an excess of labeling reagent to produce derivatized glycosylamines.
Matthew A. Lauber, Darryl W. Brousmiche, Stephan M. Koza
Filed: 11 May 22
Utility
Interface Module for Two-dimensional Liquid Chromatography
18 Aug 22
Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module.
Sylvain Gilles Cormier, Charles H. Phoebe, JR.
Filed: 29 Apr 22
Utility
Affinity resins and sample preparation devices based on cartilaginous fish IgNAR derived binding domains
16 Aug 22
The present disclosure relates to protein arrays and methods of using the same for the detection, quantification and characterization of biomolecules that specifically bind to the array among various other biomolecules in a biological sample.
Matthew A. Lauber, Xiaoxiao Liu, Beatrice Muriithi, Edouard S. P. Bouvier
Filed: 11 Aug 20
Utility
System and Method for Controlling Fluid Flow Within a Liquid Chromatography System
11 Aug 22
The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system.
Michael O. Fogwill, Theodore A. Dourdeville
Filed: 28 Apr 22
Utility
Encapsulated Pre-analytic Workflows for Flow-through Devices, Liquid Chromatography and Mass Spectrometric Analysis
11 Aug 22
This invention relates to encapsulated reagents for sample and workflow preparation prior to chromatographic, spectroscopic or other analytical systems, use thereof, and devices comprising the same.
Kevin Daniel Wyndham, Darryl W. Brousmiche
Filed: 17 Feb 22
Utility
Thermally-controlled Low Pressure Mixing System for Liquid Chromatography
4 Aug 22
Described is a solvent manager for a liquid chromatography system.
Timothy M. Raymond, Peter MacKinnon, Michael R. Jackson
Filed: 31 Jan 22
Utility
Mobile phase controller for supercritical fluid chromatography systems
2 Aug 22
The present disclosure relates to an apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system.
Joshua A. Shreve
Filed: 26 Aug 19
Utility
Rotary Valve Having Bypass State
28 Jul 22
Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels.
Sylvain Gilles Cormier, Charles T. Murphy, Joseph D. Michienzi
Filed: 25 Jan 22
Utility
Variable Fluidic Restrictor Having Selective Restriction
21 Jul 22
A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided.
Zongren Shang, Stanislaw Koziol, Joseph D. Michienzi, Michael Eggertson, Keith Fadgen
Filed: 8 Apr 22
Utility
Autosampler Seal Pack for Reducing a Carryover Percentage
21 Jul 22
A seal pack of a sample manager of a liquid chromatography system having a plurality of wash flow pathways fluidically connected to a central pathway that accommodates a sample needle, wherein a first wash flow pathway is vertically offset from a second wash flow pathway, such that a wash solution flows axially along an exterior surface of the sample needle in a vertical direction to wash the sample needle when flowing from the first wash flow pathway to the vertically offset second wash flow pathway, is provided.
Joshua A. Burnett, Marc E. Lemelin, Sylvain Gilles Cormier
Filed: 8 Apr 22
Utility
Chromatographic filter
19 Jul 22
The invention provides filters and methods of assembling filters.
Mathew H. Delano, Jonathan Belanger, Raymond P. Fisk
Filed: 6 Jun 14
Utility
Liquid chromatography/mass spectrometry methods for the analysis of polar molecules
19 Jul 22
A mixed-mode chromatography method for the determination of phosphorylated sugars in a sample is provided.
Paul D. Rainville, Kerri M. Smith
Filed: 25 Jul 19
Utility
Active Check Valve Having a Moving Magnet Actuator
14 Jul 22
Described is an active check valve that uses electro-magnetic actuation for operation.
Sean Eric Anderson, Wade P. Leveille
Filed: 6 Jan 22
Utility
Change Detection In Material Testing
14 Jul 22
Disclosed is a material testing system that includes a fixture, a frame, a load sensor, a displacement sensor and a computer system coupled to the material testing system.
David L. Dingmann
Filed: 21 Dec 21
Utility
Sorbent particles for sample treatment
5 Jul 22
Sorbents, devices, kits and methods useful for sample treatment are disclosed herein.
Darryl W. Brousmiche, Kevin D. Wyndham, Nicole L. Lawrence, Jacob N. Fairchild, Bonnie A. Alden
Filed: 2 Oct 19