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Waters (WAT)

273 patents

Page 8 of 14
Utility
High surface area chromatographic device with low pressure drop
22 Jun 21
A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective.
Abhijit Tarafder, Moon Chul Jung, Edouard S. P. Bouvier
Filed: 5 Mar 19
Utility
Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
15 Jun 21
Solutions, detection methods and chromatographic systems are provided for electrospray ionization of glycans modified with amphipathic, strongly basic moieties.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
Polyanionic Acids to Improve Recovery and Minimize System Loss
10 Jun 21
The present technology relates to a method of separating a sample comprising oligonucleotides.
Michael Donegan, Martin Gilar, Matthew Lauber, Scott Mccall, Pamela Iraneta, Kerri Smith
Filed: 4 Dec 20
Utility
Porous Inorganic/organic Hybrid Materials with Ordered Domains for Chromatographic Separations and Processes for Their Preparation
10 Jun 21
Porous hybrid inorganic/organic materials comprising ordered domains are disclosed.
Kevin D. Wyndham, John E. O'Gara
Filed: 14 Sep 20
Utility
Chelator Based Eluents for Solid Phase Extraction of Phosphorylated Compounds
10 Jun 21
The present technology relates to a method for improved recovery of phosphorylated compounds (e.g., phosphorylated glycans).
Xiaoxiao Liu, Matthew Lauber, Michael Donegan
Filed: 4 Dec 20
Utility
Use of Vapor Deposition Coated Flow Paths for Improved Chromatography of Metal Interacting Analytes
3 Jun 21
A chromatographic device including a coated metallic frit is disclosed.
Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
Filed: 3 Feb 21
Utility
Methods for scaling between chromatographic systems using highly compressible fluids
1 Jun 21
Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile.
Jason F. Hill, Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Abhijit Tarafder
Filed: 9 Apr 18
Utility
Isothermal Calorimeter
27 May 21
Described is a calorimeter that includes a thermal column, a sample container, a reference container, a thermal shield, a diffusion-bonded block and a thermal plate.
Donald J. Russell, David Serrell
Filed: 4 Nov 20
Utility
Sample Injection for Liquid Chromatography Using Split Solvent Flow
27 May 21
Described herein are a selectable flow restriction device and a fluidic network for chromatographic sample dilution during injection.
Jason F. Hill, Sylvain Gilles Cormier, Martin Gilar
Filed: 11 Nov 20
Utility
Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Passive Dampening Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Active Dampening Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Techniques for processing of mass spectral data
18 May 21
Techniques for performing data acquisition and analysis are described.
Scott J. Geromanos, Steven J. Ciavarini, Curt Devlin
Filed: 17 Jan 20
Utility
Materials and Methods for Mixed Mode, Anion Exchange Reversed Phase Liquid Chromatography
13 May 21
In various aspects, the present disclosure pertains to high purity chromatographic materials that comprise a chromatographic surface wherein the chromatographic surface comprises a hydrophobic modifier and an ionizable modifier comprising one or more anion exchange moieties that are positively charged when ionized, as well as devices containing such materials.
Matthew A. Lauber, Xiaoxiao Liu, Qi Wang, Nicole Lawrence
Filed: 6 Nov 20
Utility
Sample organizer, tray, system and method
11 May 21
A liquid chromatography sample organizer includes a first chamber, a plurality of stacked sample organizer shelves mounted within the first chamber each individually configured to store a sample-vial carrier including a sample, and a shelf magnet affixed to a surface of each of the plurality of stacked sample organizer shelves.
David A. Simpson, Joshua A. Burnett, Marc E. Lemelin, Paul Keenan, Peter Osswald
Filed: 12 Jun 19
Utility
Techniques for Temperature Control of Separation Devices and Optical Detection Devices of Mass Analysis Systems
6 May 21
Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described.
Mark J. Basile, Jeffrey Musacchio, Michael O. Fogwill, Sebastien Besner, Joseph D. Michienzi, Wade P. Leveille
Filed: 30 Oct 20
Utility
Method and apparatus for scaling between chromatographic systems using highly compressible fluids
4 May 21
Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column.
Joseph D. Michienzi, Joshua A. Shreve, Jason F. Hill, Abhijit Tarafder, Michael O. Fogwill, Keith Fadgen
Filed: 9 Apr 18
Utility
Solvent Delivery System for Liquid Chromatography That Maintains Fluid Integrity and Pre-forms Gradients
29 Apr 21
A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column.
Steven J. Ciavarini, Stanley P. Pensak, JR., Jeffrey W. Finch, Keith Fadgen, Hongji Liu
Filed: 7 Jan 21
Utility
High purity chromatographic materials comprising an ionizable modifier
13 Apr 21
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Kevin D. Wyndham, Pamela C. Iraneta, Thomas H. Walter
Filed: 28 Nov 18
Utility
Systems, methods, and devices providing solvent container identification and incorporation
23 Mar 21
Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection.
Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
Filed: 17 Jan 18
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