230 patents
Utility
Solvent Reservoir Configuration for Steady Flow and Monitoring Solvent Level and Density
18 Jan 24
Disclosed herein are solvent reservoir systems for steady flow delivery and simultaneous monitoring of solvent level and solvent density within the solvent reservoir systems and methods for monitoring the solvent reservoir systems and providing feedback to a user or adjusting the systems in response to the monitored characteristics.
Sean Eric Anderson
Filed: 1 Sep 23
Utility
LC/MS Adduct Mitigation by Vapor Deposition Coated Surfaces
21 Dec 23
The present disclosure discusses a method of separating a sample (e.g., small organic acid metabolite) including coating a flow path of a chromatographic system.
Kerri M. Smith, Paul Rainville
Filed: 29 Jun 23
Utility
Preparation of Lipid Nanoparticle Encapsulated Nucleic Acid Samples for Accurate Compositional Analysis
14 Dec 23
The present disclosure is directed to methods of sample preparation from lipid nanoparticle (LNP)-encapsulated nucleic acids utilizing solid-phase extraction techniques.
Matthew A. Lauber, Bonnie Alden, Mame Maissa Gaye
Filed: 3 Jun 23
Utility
Use of Vapor Deposition Coated Flow Paths for Improved Chromatography of Metal Interacting Analytes
7 Dec 23
Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan Belanger, Theodore A. Dourdeville, Kerri Smith, Paul Rainville, Dimple Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
Filed: 7 Jun 23
Utility
Use of Vapor Deposition Coated Flow Paths for Improved Analytical Analysis
7 Dec 23
Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
Filed: 7 Jun 23
Utility
a Method of Calibrating a Mass Spectrometer
30 Nov 23
We provide a method of assessing an acquired mass spectrum, the method including the steps of: obtaining a model isotope pattern for a chemical compound of known elemental composition, providing mass spectrum data obtained from a mass spectrometer in analysis of the chemical compound, and performing location matching by comparing the mass spectrum data to the isotope pattern to match a reference location in the isotope pattern with respective corresponding candidate locations in the mass spectrum data, the location matching including: determining a likelihood function over the mass spectrum data, representing the likelihood that each location in the mass spectrum data correctly corresponds to the reference location of the isotope pattern, determining a set of candidate locations each corresponding to a local maxima in the determined likelihood function, and at each candidate location, determining an associated error bar based on the curvature of the likelihood function at that location.
Maria GAFFNEY-LOVETT, Richard DENNY
Filed: 21 Oct 21
Utility
Methods of Calibrating a Mass Spectrometer
23 Nov 23
Methods of calibrating a mass spectrometer include: experimentally determining the mass to charge ratios of a plurality of chemical compounds in a reference standard using a mass spectrometer configured to scan ions at a first scan speed; experimentally determining the mass to charge ratios of said plurality of chemical compounds in said reference standard using a mass spectrometer configured to scan ions at a second scan speed; generating sets of data corresponding to each chemical compound, each set of data comprising the experimentally determined mass to charge ratios and the first and second scan speeds; interpolating from the sets of data mass to charge ratio for each chemical compound at a scan speed different from the first and second scan speeds; and constructing a calibration curve using the mass to charge ratios interpolated from the sets of data.
Richard Denny, Maria Gaffney-Lovett
Filed: 20 Aug 21
Utility
Dual Stationary Phase Gradient Columns for New Selectivities In Liquid Chromatography
16 Nov 23
The present disclosure is directed to liquid chromatography columns and methods utilizing a stationary phase sorbent having two or more gradient factors.
Szabolcs Fekete, Matthew A. Lauber
Filed: 12 May 23
Utility
Method of Analysis of Polynucleotides by Restricted Access Reversed Phase Chromatography
16 Nov 23
The present disclosure discusses a method of separating and/or purifying polynucleotides.
Matthew A. Lauber, Catalin Doneanu, Weibin Chen, Ying Qing Yu, Jennifer M. Nguyen, Fabrice Gritti, Martin Gilar
Filed: 8 May 23
Utility
Fluidic Configuration for a Multidimensional Liquid Chromatography System
16 Nov 23
Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 25 Jul 23
Utility
Fluidic Network for Aseptic Sampling
9 Nov 23
Described are a fluidic network and a method for aseptic process sampling.
Sylvain Gilles Cormier
Filed: 3 May 23
Utility
Fluidic Network for Positive Displacement Aseptic Sampling
9 Nov 23
Described are a fluidic network and method for aseptic sampling from a process source.
Sylvain Gilles Cormier, Michael O. Fogwill
Filed: 3 May 23
Utility
Sample Manager, System and Method
28 Sep 23
A method of aspirating a sample includes moving a sample needle downward to a first position so a tip of the sample needle touches a bottom of the sample container, determining that the tip of the sample needle is in the first position where the sample needle is in contact with the bottom of the sample container, after the determining that the tip of the sample needle is in contact with the bottom of the sample container, incrementally moving the sample needle upward from the first position, determining the sample needle has moved a predetermined distance upward from the first position and then aspirating a sample in the sample container.
David Zielinski
Filed: 23 Mar 23
Utility
Superficially Porous Materials Comprising a Coated Core Having Narrow Particle Size Distribution; Process for the Preparation Thereof; and Use Thereof for Chromatographic Separations
21 Sep 23
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Nicole L. Lawrence, Daniel P. Walsh, Jacob Nathan Fairchild, Kevin Daniel Wyndham
Filed: 3 May 23
Utility
Aptamer Based Affinity Capture Methods for the Selective Enrichment of Human Immunoglobulin FC Domains
21 Sep 23
A method of capturing human immunoglobulin Fc domains in a biofluid sample is provided.
Xiaoxiao Liu, Matthew A. Lauber
Filed: 6 Jan 23
Utility
High Purity Chromatographic Materials Comprising an Ionizable Modifier for Retention of Acidic Analytes
17 Aug 23
The present invention provides the use of charged surface reversed phase chromatographic materials along with standard reversed-phase LC and mass spectrometry compatible conditions for the retention, separation, purification, and characterization of acidic, polar molecules, including, but not limited to, organic acids, α-amino acids, phosphate sugars, nucleotides, other acidic, polar biologically relevant molecules.
Matthew A. Lauber, Paul Rainville, Jacob N. Fairchild, Babjide Okandeji, Nicole L. Lawrence, Dimple Shah
Filed: 25 Apr 23
Utility
Hydrophobicity Shifted Enzyme
17 Aug 23
The present invention relates to a method for analyzing a sample, the method comprising: (a) incubating a sample comprising an analyte with at least one enzyme to produce a digestion mixture comprising fragments of the analyte; (b) loading the digestion mixture onto a reversed-phase chromatography column; and (c) performing reversed-phase chromatography on the digestion mixture, wherein the at least one enzyme is hydrophobically modified to increase a retention time of the at least one enzyme such that the at least one enzyme elutes from the reversed-phase chromatography column later than the fragments of the analyte.
Matthew Lauber, Wenjing Li
Filed: 10 Feb 23
Utility
Liquid-chromatography Apparatus Having Diffusion-bonded Titanium Components
10 Aug 23
A liquid chromatography apparatus includes a diffusion-bonded separation column comprising a lower substrate comprising titanium, an upper substrate comprising titanium, and a titanium patterned foil disposed between the lower substrate and the upper substrate.
Theodore A. Dourdeville
Filed: 21 Apr 23
Utility
Nanospray Reactive Sprayer
3 Aug 23
Described are an apparatus for generating and collecting nanospray reactive droplets and a method for analyzing a protein digestion.
Lindsay Morrison
Filed: 12 Jan 23
Utility
an Atmospheric Pressure Ionisation Source
6 Jul 23
An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an aperture for receiving at least the distal end of a capillary into the ionisation chamber in use, the aperture having a capillary axis; a desolvation heater having a nozzle, for directing a stream of heated gas onto the distal end of the capillary in use, the nozzle having a nozzle axis; a corona discharge device including a corona pin having a corona axis, the corona pin for ionizing a sample in the ionisation chamber in use; and an inlet cone of a mass spectrometer arranged in the ionisation chamber, the inlet cone defining a cone entrance having a cone axis, wherein the cone axis is substantially coaxial with the corona axis and the capillary axis is substantially perpendicular to and intersects with the nozzle axis.
Arvind Rangan, Carl Chen, Steven Rocha, Enchen Guo, Nicola Lumley, David Douce, Richard Gallagher, Kate Whyatt
Filed: 5 May 21