230 patents
Page 3 of 12
Utility
Passive Solvent Mixer for Liquid Chromatography
29 Dec 22
Described is a mixer for a liquid chromatography system.
Fabrice Gritti
Filed: 24 May 22
Utility
Fluorescence Tagging of Glycans and Other Biomolecules Through Reductive Amination for Enhanced MS Signals
29 Dec 22
Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 3 Jun 21
Utility
High Sample Throughput Differential Scanning Calorimeter
22 Dec 22
Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time.
Donald J. Russell, David Serrell, Anthony E. Arnerich
Filed: 23 Aug 22
Utility
Techniques for Mass Spectrometry Peak List Computation Using Parallel Processing
22 Dec 22
Described are techniques for processing data.
Jose DE CORRAL
Filed: 28 Feb 22
Utility
Separation of Nucleic Acid Component Compounds on Zwitterionic Stationary Phases
8 Dec 22
The present disclosure pertains to methods of separating nucleic acid component compounds from one another.
Kenneth Berthelette
Filed: 3 Jun 22
Utility
Check Valve Having a Spherical Loading Element
1 Dec 22
Described is a check valve having a valve housing, a valve seat, a ball and a spherical loading element.
Christopher Walden
Filed: 6 May 22
Utility
Methods of Enhancing MS Detection of Tagged Glycans
1 Dec 22
Methods for derivatization of biomolecules including glycans or other biopolymers with one or more fluorescent, MS active compounds by reductive amination or rapid tagging in order to produce derivatized glycan having a pKa >7 and between about 200 Å and about 1000 Å of nonpolar surface area are described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 2 May 22
Utility
Equal Dispersion Split-flow Mixer
24 Nov 22
Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path.
Peter MacKinnon, Michael R. Jackson
Filed: 9 May 22
Utility
Hydrolytically Stable Zwitterionic Chromatographic Materials
17 Nov 22
In some aspects, the present disclosure pertains to chromatographic materials that comprise (a) a bulk material and (b) a zwitterionic polymer covalently linked to a surface of the bulk material, in which the zwitterionic polymer comprises one or more monomer residues that comprise an amide or urea moiety, a positively charged moiety, and a negatively charged moiety.
Nicole L. Lawrence, Darryl W. Brousmiche, Jessica Field, Daniel P. Walsh
Filed: 28 Apr 22
Utility
Compact Liquid Chromatography System Providing Thermal Management and Detection
10 Nov 22
The exemplary embodiments may provide liquid chromatography systems that are smaller in size and with reduced extra-column volume than conventional liquid chromatography systems.
Michael O. Fogwill, Fabrice Gritti
Filed: 4 May 22
Utility
Establishing Fluidic Connections Between Chromatography Components
10 Nov 22
A thermal module for pre-heating liquid flowing into a liquid chromatography column, includes a trough compartment with two ends, one of the two ends having an electrical socket, a first fluidic assembly, a second fluidic assembly, and a clamp assembly.
Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan M. Hill, Raymond P. Fisk, Jonathan L. Belanger, Wade P. Leveille
Filed: 14 Jul 22
Utility
Solvent Delivery with a Reduced Volume Single Stroke Pumping Arrangement Providing Continuous Solvent Flow
6 Oct 22
The exemplary embodiments control solvent pumps so that system flow is constant.
Michael O. Fogwill, Sylvain G. Cormier
Filed: 30 Mar 22
Utility
Automated Semi-preparative Gradient Recycling Liquid Chromatography
29 Sep 22
The disclosure relates to a gradient twin column recycling chromatography method that is used to separate a mixture containing closely eluting compounds.
Fabrice Gritti
Filed: 21 Mar 22
Utility
Sorbent Particles for Sample Treatment
8 Sep 22
Novel sorbents, devices, kits and methods useful for sample treatment are disclosed herein.
Darryl W. Brousmiche, Kevin D. Wyndham, Nicole L. Lawrence, Jacob N. Fairchild, Bonnie Alden
Filed: 23 May 22
Utility
Compositions, Kits and Methods Useful for Analyzing Antibody-containing Samples
1 Sep 22
In some aspects, the present disclosure pertains to sample treatment methods that comprise: contacting an acidic elution solution that is free of primary amine, secondary amine and thiol groups with a sorbent having bound target antibody and separating the elution solution from the sorbent, thereby releasing bound target antibody from the sorbent and forming a first collection fraction that comprises the elution solution and released target antibody; contacting the sorbent with a neutralization buffer solution that is free of primary amine, secondary amine and thiol groups and separating the neutralization buffer solution from the sorbent, thereby forming a second collection fraction that comprises the neutralization buffer solution; and forming a neutralized solution that comprises the first collection fraction and the second collection fraction.
Matthew A. Lauber, Xiaoxiao Liu
Filed: 3 Feb 22
Utility
Methods and Kits for Universal Calibration of Lateral Flow Testing
25 Aug 22
The present disclosure provides methods and kits for detecting an analyte within a sample by using lateral flow testing.
Lingyun Chen, Justine Yu
Filed: 16 Feb 22
Utility
Methods for the Rapid Preparation of Labeled Glycosylamines and for the Analysis of Glycosylated Biomolecules Producing the Same
25 Aug 22
Methods of analyzing glycosylated biomolecules include the steps of producing a deglycosylation mixture of biomolecules deglycosylated by natural or synthetic enzymatic or chemical techniques; providing a reagent solution having a labeling reagent in a polar aprotic, non-nucleophilic organic solvent; and mixing the deglycosylation mixture with the reagent solution in an excess of labeling reagent to produce derivatized glycosylamines.
Matthew A. Lauber, Darryl W. Brousmiche, Stephan M. Koza
Filed: 11 May 22
Utility
Methods for Peptide Mapping of Adeno-associated Virus (Aav) Proteins
25 Aug 22
The present disclosure relates to a method of characterizing proteins in a sample.
Ximo Zhang, Stephan M. Koza, Ying Qing Yu, Weibin Chen
Filed: 7 May 21
Utility
Interface Module for Two-dimensional Liquid Chromatography
18 Aug 22
Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module.
Sylvain Gilles Cormier, Charles H. Phoebe, JR.
Filed: 29 Apr 22
Utility
System and Method for Controlling Fluid Flow Within a Liquid Chromatography System
11 Aug 22
The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system.
Michael O. Fogwill, Theodore A. Dourdeville
Filed: 28 Apr 22