196 patents
Utility
Methods for the evaluation of system inertness
16 Jan 24
The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system.
Amit Patel, Moon Chul Jung, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
Filed: 10 Sep 21
Utility
Multidimensional chromatography method for analysis of antibody-drug conjugates
19 Dec 23
The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
Robert Birdsall
Filed: 24 Sep 21
Utility
Fixture identification in test systems
19 Dec 23
Described are systems and methods for fixture identification in test systems.
David L. Dingmann
Filed: 15 Jan 21
Utility
Isothermal calorimeter
12 Dec 23
Described is a calorimeter that includes a thermal column, a sample container, a reference container, a thermal shield, a diffusion-bonded block and a thermal plate.
Donald J. Russell, David Serrell
Filed: 4 Nov 20
Utility
Ion detector
12 Dec 23
An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.
Joseph A. Jarrell, Martin Gilar
Filed: 8 Apr 21
Utility
Linear motor
12 Dec 23
A linear motor including a stator assembly, an armature mechanically coupleable to a test specimen configured to be moved relative to the stator assembly by operation of the linear motor, and a suspension system configured facilitate movement of the armature relative to the stator assembly along an axis of movement without physically touching the armature during movement.
Charles Groepper, Sudarshan Betigeri, David L. Dingmann, Kevin Alstrin, Nicholas Fruge
Filed: 21 Jan 20
Utility
Sample metering and injection for liquid chromatography
5 Dec 23
A method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow include a metering pump module, a sample needle, a needle seal and an injection valve.
Joshua A. Burnett, Rose Solow, David A. Simpson
Filed: 18 Dec 20
Utility
Techniques for analytical instrument performance diagnostics
5 Dec 23
Techniques and apparatus for diagnostic processes for analytical instruments are described.
John Carneiro, Richard Earle, Aaron Lebeau, Robert J Dumas, David Lamborghini
Filed: 10 Jun 20
Utility
Device for solid phase extraction and method for use thereof
21 Nov 23
Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis.
Pamela C. Iraneta, Xin Zhang, Frank John Marszalkowski, Jr.
Filed: 13 Oct 21
Utility
Active check valve having a moving magnet actuator
21 Nov 23
Described is an active check valve that uses electro-magnetic actuation for operation.
Sean Eric Anderson, Wade P. Leveille
Filed: 6 Jan 22
Utility
Active dampening gradient proportioning valve
21 Nov 23
Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Passive dampening gradient proportioning valve
21 Nov 23
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Continuous flow mixer
21 Nov 23
A continuous flow mixer for use in a chromatography system includes a first channel structure located between a mixer inlet and a mixer outlet.
Sean Eric Anderson, Peter MacKinnon
Filed: 22 Sep 21
Utility
Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry
31 Oct 23
The present disclosure relates to a streamlined, complete workflow for the qualitative and the quantitative analysis of conjugated peptides from antibody-drug conjugate (ADC) compounds.
Liuxi Chen, Weibin Chen, Steven Cubbedge
Filed: 2 Mar 17
Utility
Multiple sample differential scanning calorimeter
24 Oct 23
A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided.
Robert L. Danley
Filed: 10 Nov 21
Utility
Establishing fluidic connections between chromatography components
24 Oct 23
A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism.
Wade P. Leveille, Joseph D. Michienzi, Joseph D. Antocci, Jeffrey Musacchio
Filed: 26 Apr 21
Utility
Sprayer assembly for DESI applications
24 Oct 23
A sprayer assembly for an ion source is disclosed.
Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio, Emrys Jones, Steven Derek Pringle, Stephen Hattan, Gregory T. Roman
Filed: 22 Jan 21
Utility
Solvent reservoir configuration for steady flow and monitoring solvent level and density
17 Oct 23
Disclosed herein are solvent reservoir systems for steady flow delivery and simultaneous monitoring of solvent level and solvent density within the solvent reservoir systems and methods for monitoring the solvent reservoir systems and providing feedback to a user or adjusting the systems in response to the monitored characteristics.
Sean Eric Anderson
Filed: 7 Jun 21
Utility
Fitting for fluidic coupling in a chromatography system
10 Oct 23
A fitting for fluidic coupling in a chromatography system includes a compression screw including an axial bore, a threaded portion, and a drive end, a tube assembly including a tube sleeve and an inner tube disposed through the sleeve, the tube sleeve and the inner tube each extending to an endface of the tube assembly, the tube sleeve including an outer surface, a seal body extending between a first endface and a second endface, the first endface abutting the endface of the tube assembly, the seal body including an outer surface, and a collar secured to the outer surface of the tube sleeve and the outer surface of the seal body.
Mark W. Moeller, William B. Clark, Charles T. Murphy
Filed: 12 Aug 20
Utility
Metering pump for liquid chromatography
3 Oct 23
Described is a metering pump that may be used to meter volumes of sample in a chromatography system.
Joshua A. Burnett, Rose Solow, David A. Simpson, Peter Osswald, John M. Auclair, Michael LeBeau
Filed: 25 Mar 21