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Waters (WAT)

128 patents

Page 4 of 7
Utility
Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
17 Aug 21
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans.
Matthew A. Lauber, Stephan M. Koza, Pamela C. Iraneta, Kevin D. Wyndham
Filed: 2 Apr 15
Utility
Polar pesticide determination using chromatography
17 Aug 21
The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography.
Dimple D. Shah, Jacob N. Fairchild, Euan Ross, Benjamin Wuyts
Filed: 7 Mar 18
Utility
Devices and methods for analyzing intact proteins, antibodies, antibody subunits, and antibody drug conjugates
17 Aug 21
The present disclosure relates devices and methods for analyzing intact antibodies, antibody subunits, antibody drug conjugate subunits, antibody drug conjugates, and intact proteins in a biological mixture.
Gregory T. Roman, James P. Murphy
Filed: 27 Feb 18
Utility
Techniques for monitoring chromatographic fluid flows
10 Aug 21
Various embodiments are generally directed to techniques for monitoring chromatographic fluid flows, such as the flow to and/or from one or more reservoirs used in chromatographic operations, for instance.
Abhijit Tarafder, Jonathan Belanger, Moon Chul Jung, Wade P. Leveille
Filed: 12 Jun 19
Utility
Continuous determination of medium stiffness and load gain for adaptive actuator control
3 Aug 21
An actuator control system, mechanical testing system, and method for adaptive control of an actuator of a mechanical testing device may include determining a stiffness of a medium that the actuator is moving through and/or load gain of the actuator, wherein the stiffness and load gain is determined by generating a waveform to actuate the actuator until a load sensor signal and/or a displacement sensor signal is received, and controllably moving the actuator through the medium according to a predefined constant velocity by calculating a current request using the stiffness of the medium, and/or adjusting the load of the actuator in accordance with a constant load ramp rate.
Kevin Alstrin
Filed: 2 Oct 18
Utility
Systems and methods for chromatographic analysis
3 Aug 21
Methods of chromatographic detection are provided that include the step of providing a chromatography instrument without an autosampler, an external device, a pressurized sample injection device and a chromatographic data system.
Aaron D. Phoebe, Sylvain G. Cormier, Charles H. Phoebe, Jr.
Filed: 24 Sep 18
Utility
Porous carbon-heteroatom-silicon inorganic/organic materials for chromatographic separations and process for the preparation thereof
27 Jul 21
The present disclosure provides porous carbon-heteroatom-silicon inorganic/organic homogenous copolymeric hybrid materials, methods for their preparation, and uses thereof, e.g., as chromatographic separations materials.
Kevin D. Wyndham, John E. O'Gara
Filed: 16 Jan 17
Utility
Chromatographic materials
13 Jul 21
In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1).
Kevin D. Wyndham, Michael F. Morris, Darryl W. Brousmiche, Jason F. Hill, Jacob N. Fairchild
Filed: 20 Mar 19
Utility
Method and apparatus for injecting a chromatographic sample
13 Jul 21
Described are a method and apparatus for diluting a chromatographic sample.
Martin Gilar, Keith Fadgen, Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews, Geoff C. Gerhardt, Jordan Kornfeld, Thomas S. McDonald
Filed: 15 Oct 19
Utility
Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced MS signals
13 Jul 21
Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
High surface area chromatographic device with low pressure drop
22 Jun 21
A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective.
Abhijit Tarafder, Moon Chul Jung, Edouard S. P. Bouvier
Filed: 5 Mar 19
Utility
Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
15 Jun 21
Solutions, detection methods and chromatographic systems are provided for electrospray ionization of glycans modified with amphipathic, strongly basic moieties.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
Methods for scaling between chromatographic systems using highly compressible fluids
1 Jun 21
Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile.
Jason F. Hill, Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Abhijit Tarafder
Filed: 9 Apr 18
Utility
Techniques for processing of mass spectral data
18 May 21
Techniques for performing data acquisition and analysis are described.
Scott J. Geromanos, Steven J. Ciavarini, Curt Devlin
Filed: 17 Jan 20
Utility
Sample organizer, tray, system and method
11 May 21
A liquid chromatography sample organizer includes a first chamber, a plurality of stacked sample organizer shelves mounted within the first chamber each individually configured to store a sample-vial carrier including a sample, and a shelf magnet affixed to a surface of each of the plurality of stacked sample organizer shelves.
David A. Simpson, Joshua A. Burnett, Marc E. Lemelin, Paul Keenan, Peter Osswald
Filed: 12 Jun 19
Utility
Method and apparatus for scaling between chromatographic systems using highly compressible fluids
4 May 21
Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column.
Joseph D. Michienzi, Joshua A. Shreve, Jason F. Hill, Abhijit Tarafder, Michael O. Fogwill, Keith Fadgen
Filed: 9 Apr 18
Utility
High purity chromatographic materials comprising an ionizable modifier
13 Apr 21
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Kevin D. Wyndham, Pamela C. Iraneta, Thomas H. Walter
Filed: 28 Nov 18
Utility
Systems, methods, and devices providing solvent container identification and incorporation
23 Mar 21
Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection.
Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
Filed: 17 Jan 18
Utility
Multi-injection mode valve module
23 Mar 21
A chromatography system has an associated system volume and a sample dispersion volume.
Sylvain Cormier, Richard W. Andrews, Peyton C. Beals
Filed: 17 Feb 16
Utility
System and method for diagnosing a condition of a restrictor
23 Mar 21
The present disclosure relates to methodologies, systems, apparatus, and kits for diagnosing the condition of a restrictor element in a chromatography system based on flow rate measurements, or pressure measurements, or both.
Michael O. Fogwill
Filed: 11 Oct 18
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